STAT3 deficiency

Patients with STAT3 deficiency have skeletal/dental abnormalities, skin abcesses, cyst-forming pneumonia and highly elevated serum IgE.

Therapeutic options

  • Intravenous immunoglobulins should be used for the antibody deficiency. Antibiotic therapy (10-14 days) together with physiotherapy and postural drainage in case of lung damage. Ciprofloxacin is a valuable antibiotic but is not licensed for small children. Oral poliovaccine should not be given because there is risk of paralytic disease.
  • Hyperimmunoglobulinemia E (Job) Syndrome, eMedicine
  • Job Syndrome, eMedicine

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