STAT3 deficiency

Gene Information


HUGO name: STAT3


Reference sequences

Chromosomal location


Protein Information


Protein function:

Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by il31 through il31ra


Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with NCOAL, PELP1, SOCS7 and STATIP1. Interacts with HCV core protein. Interacts with IL23r in presence of IL23. Interacts with IL31ra

Subcellular location:

Cytoplasm. Nucleus. Note=translocated into the nucleus in response to phosphorylation

Post-translational modification:

Tyrosine phosphorylated in response to IL-6, IL-11, CNTF, LIF, CSF-1, EGF, PDGF, IFN-alpha and OSM. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity

Alternative products:

Event=alternative splicing; named isoforms=2; name=1; isoid=p40763-1; sequence=displayed; name=del-701; isoid=p40763-2; sequence=vsp_010474;


Involved in the GP130-mediated signaling pathway

Tissue specificity:

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas


Belongs to the transcription factor STAT family

Structures (PDB)


Expression pattern for human

Tissue Expression (%) Clones
mouth 12.35 49:42918
trachea 7.21 34:51029
dorsal_root_ganglion 6.43 5:8404
spleen 5.97 27:48893
nerve 4.15 6:15651
thymus 3.84 27:76036
rectum 3.65 2:5929
salivary_gland 3.38 6:19187
thyroid 3.37 3:9629
tonsil 3.06 5:17653

Animal models