Printable factfile
Gene Information
Names
HUGO name: TAP2
Alias(es):
- ABCB3
- D6S217E
- PSF2
- RING11
- Y1
- ATP-binding cassette, sub-family B (MDR/TAP), member 3
- transporter 2, ABC
- ATP binding cassette
- transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
- Antigen peptide transporter 2
- APT2
- Peptide transporter TAP2
- Peptide transporter PSF2
- Peptide supply factor 2
- PSF-2
- Peptide transporter involved in antigen processing 2
Localization
Reference sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
Involved in the transport of antigens from the cytoplasm to a membrane-bound compartment for association with MHC class I molecules.
Subunit:
Heterodimer of TAP1 and TAP2.
Subcellular location:
Integral membrane protein.
Induction:
By interferon gamma.
Polymorphism:
The following alleles of TAP2 are known: TAP2*0101, TAP2*0102 (TAP2e), TAP2*0103 and TAP2*0201 (psf2b).
Other features
ATP nucleotide phosphate-binding region: 503-510
Other related resourses:
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| leukocyte | 13.25 | 3:8982 |
| aorta, endothelium | 13.04 | 1:3042 |
| ovary (pool of 3) | 9.06 | 1:4380 |
| leukopheresis | 8.71 | 1:4557 |
| rpe and choroid | 7.51 | 2:10565 |
| blood | 6.27 | 2:12646 |
| B-cells | 4.80 | 2:16533 |
| blood, lymphocyte | 3.50 | 1:11328 |
| mixed | 3.29 | 5:60341 |
| stomach | 2.88 | 8:110283 |