C7 deficiency

Patients with C7 deficiency have markedly diminished total hemolytic complement activity and little if any C7 in their serum. Serum bactericidal activity is markedly reduced and is responsible for the increased risk of neiserrial infections in C7-deficient patients. In the second type of C7 deficiency, the quantity of C7 is diminished and the protein exhibits an altered isoelectric point. C7 deficiency has been in association with subtotal deficiency of C6.

Alternative names

C7 deficiency

Complement component 7 deficiency


  • Defects of the classical complement cascade proteins


Autosomal recessive