Cyclic neutropenia

Symptoms associated with cyclic neutropenia may include fever, a general feeling of ill health (malaise), skin and oropharyngeal inflammation (mouth ulcers, gingivitis, sinusitis, and pharyngitis). In most cases, individuals with low levels of neutrophils (neutropenia) are abnormally susceptible to recurrent infections. Cyclic neutropenia is usually diagnosed within the first years of life based on recurrent fever and oral ulcerations occuring at 3 weeks intervals. Cellulitis is common during the neutropenic periods. Between neutropenic periods, individuals are generally healthy. Symptoms improve in adulthood. There is no risk of malignancy or conversion to leukemia.

Therapeutic options

  • Treatment with recombinant human granulocyte colony-stimulating factor (GCSF) raises blood neutrophil levels, diminishes the number of new infections and improves survival and quality of life.
  • Neutropenia, eMedicine