Transient hypogammaglobulinemia of infancy

Disease has an early onset. Patients present bacterial infections occuring after 6 months of age. It may last up to 36 months. Disease is characterised by recurrent respiratory infections and otitis media, bronchitis and/or bronchial asthma and recurrent gastroenteritis. During the first years of lives there is a high incidence of recurrent upper respiratory infections but usually not pneumonias or life-threatening infections. The presence of normal B-cell numbers differentiates THI from XLA. IgM is frequently normal.

Therapeutic options

  • (Intravenous)immunoglobulins may be required and should always be used for a fixed period and be withdrawn to check for spontaneous recovery. All patients recover after treatment. If there is no recovery, than the patients has CVID.
  • Transient hypogammaglobulinemia of infancy, eMedicine