IgG subclass deficiency with or without IgA deficiency

Patients who suffer recurrent infections because they lack, or have very low levels of, one or two IgG subclasses (IgG1, IgG2, IgG3 and IgG4), but whose other immunoglobulin levels are normal, are said to have a "selective IgG subclass deficiency".

Alternative names

IgG subclass deficiency


  • Deficiencies predominantly affecting antibody production
    • Selective deficiency of IgG subclass, IgE and/or IgA class or subclass



Cross references

Phenotypically related immunodeficiencies

IDR factfile for γ1 isotype deficiency

IDR factfile for α1 isotype deficiency


Incidence is not known.