Printable factfile
Gene Information
Names
HUGO name: STAT5B
Alias(es):
- STAT5
- Signal transducer and activator of transcription 5B
- Transcription factor STAT5B
Localization
Reference sequences
Chromosomal location
Maps
Markers
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRl-induced transcription.
Subunit:
Forms a homodimer or a heterodimer with a related family member. Binds NR3C1. Interacts with NMI.
Subcellular location:
Nuclear; translocated into the nucleus in response to phosphorylation.
Post-translational modification:
Tyrosine phosphorylated.
Similarity:
Belongs to the transcription factor STAT family.
Structures (PDB)
Domains
SH2 domain: 589-686
REQUIRED FOR INTERACTION WITH NMI domain: 232-321
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| Bulk germ cell seminoma | 19.01 | 1:290 |
| Normal endometrium, late proliferative phase, cycle day 13 | 5.35 | 1:1030 |
| Lymph | 5.07 | 18:19564 |
| Thymus | 5.04 | 2:2187 |
| Lung Focal Fibrosis | 4.23 | 3:3912 |
| Testis | 4.16 | 4:5295 |
| Peripheral nervous system | 3.55 | 1:1553 |
| Germ cell tumor | 2.58 | 1:2133 |
| Schizophrenic brain S-11 frontal lobe | 2.47 | 1:2229 |
| Trabecular meshwork | 2.06 | 1:2671 |
| Bulk germ cell seminoma | 19.01 | 1:290 |
| Normal endometrium, late proliferative phase, cycle day 13 | 5.35 | 1:1030 |
| Lymph | 5.07 | 18:19564 |
| Thymus | 5.04 | 2:2187 |
| Lung Focal Fibrosis | 4.23 | 3:3912 |
| Testis | 4.16 | 4:5295 |
| Peripheral nervous System | 3.55 | 1:1553 |
| Germ cell tumor | 2.58 | 1:2133 |
| Schizophrenic brain S-11 frontal lobe | 2.47 | 1:2229 |
| Trabecular meshwork | 2.06 | 1:2671 |