Bioinformatics

Schematic representation of the full-length human RAG1 (top) and RAG2 (bottom). Mutations identified in B-SCID and in Omenn syndrome patients are indicated above and below the diagram of the protein, respectively. The RAG1 protein contains Basic domains I, IIa, IIb, III (B), a ring finger domain (R), a zinc finger domain A (A), a homeodomain (H), a core domain (C) and a zinc finger domain B (B). The RAG2 protein contains a core domain (C) and an acidic domain (D).