Chediak-Higashi syndrome

Children present with partial albinism, partial lack of hair, skin and eye color and recurrent infections of the skin, mouth and respiratory tract. Patients present a deficient natural killer cell activity, susceptibility to malignant lymphoma, and the presence of large intracytoplasmic granulations in various cell types. The symptoms are so severe that most people with Chediak-Higashi syndrome die at an early age (before 7 years).