Antibody deficiency with normal immunoglobulin levels

The cause of the syndrome is unknown. It is related to IgG subclass deficiencies and there is a failure to respond to specific antigens. This entity, observed more in adults, clinically resembles common variable immunodeficiency (CVI). In small children, it is due to a maturational delay that resolves spontaneously.

Alternative names

Antibody deficiency with normal or elevated serum immunoglobulin levels

Selective antibody deficiency with normal immunoglobulins


  • Deficiencies predominantly affecting antibody production
    • Other antibody deficiencies




%240500 Common variable immunodeficiency

Cross references

Phenotypically related immunodeficiencies

IDR factfile for Common variable immunodeficiency


Incidence is not known.