Common variable immunodeficiency of unknown origin

Patients with CVID present recurrent bacterial infection, autoimmune disease like thrombocytopenia, haemolytic anaemia and organ specific autoimmunity. Nodular lymphoid hyperplasia of bowel is unique to CVID. In severe form of CVID, granulomatous disease with lymphadenopathy is common. The major complications of CVID are due to delay in diagnosis. Patients may have bronchiectasis, chronic sinusitis, unusual infections, such as Campylobacter cholangitis, and Mycoplasma/Ureaplasma arthritis. There is an increase risk of lymphoma and gastric carcinoma. Thymomas (benign or malignant) can also occur and often give rise to myasthenia gravis and haematological problems.