CD8α deficiency

CD8 glycoproteins play an important role in maturation and function of MHC class I-restricted T lymphocytes. The disease is transmitted autosomal recessive and it is an immunologic defect characterized by absence of CD8+ cells. Only one deficiency was described until now in a consanguineous family in Spain.

Alternative names

CD8A deficiency


  • Combined B and T cell immunodeficiencies
    • Other


Autosomal recessive


*186910 CD8 antigen, alpha polypeptide; CD8A

Cross references

Phenotypically related immunodeficiencies

TAP2 deficiency

TAP1 deficiency

ZAP-70 deficiency


Incidence is not known yet.