IL-2 receptor α-chain deficiency (CD25 deficiency)

CD25 deficiency begins early in life with recurrent infections and dramatic lymphocytes infiltrates in multiple tissues. The patient had a history of increased susceptibility to viral, bacterial and fungal infections. At the age of 6 months he presented cytomegalovirus pneumonitis, persistant oral thrush, and Candida esophagitis. He had also adenovirus gastroenteritis, developed chronic diarrhea, and failed to thrive. From the age of 8 months he presented lymphadenopathy and hepatosplenomegaly. He had repeted episodes of lung disease and by the age of 3 years developed gingivitis, iron deficiency anemia.

Therapeutic options