C8 β-polypeptide deficiency

Patients have inability to form membrane attack complex (MAC) and bactericidal activity is depressed. Patients are susceptible to recurrent pyogenic infections. Typically, they present with meningococcal meningitis and disseminated extragenital gonococcal infection. Two thirds of patients have at least 1 episode of meningococcal disease. Many as one half of patients experience recurrent infections.

Therapeutic options