C8 α-polypeptide deficiency

Patients have an inability to form membrane attack complex (MAC) and bactericidal activity is depressed. Patients are susceptible to recurrent pyogenic infections. Typically, they present with meningococcal meningitis and disseminated extragenital gonococcal infection. Two thirds of patients have at least 1 episode of meningococcal disease. Many patients experience recurrent infections.

Therapeutic options