Partial γ3 isotype deficiency

Immunoglobulin G sublass deficiency is defined as a decrease of an IgG sublass greater than 2 standard deviations below the normal mean for age. One or more IgG subclasses and other Ig isotypes may be involved. This deficiency may be isolated or associated with other immunodeficiencies (IgA deficiency, ataxia-telangiectasia).

Alternative names


  • Deficiencies predominantly affecting antibody production
    • Selective deficiency of IgG subclass, IgE and/or IgA class or subclass


Autosomal recessive


*147120 Immunoglobulin Gm3; IGHG3


Incidence is not known.