X-linked hypogammaglobulinemia with growth hormone deficiency

Patients with X-linked hypoglammaglobulinemia and isolated growth hormone deficiency have recurrent sinopulmonary infections, short stature and retarded bone age during childhood. The adults have delayed onset of puberty. The immunodeficiency is characterized by absent specific antibody production in vivo and impaired immunoglobulin production in vitro. Patients have deficient growth hormone responses to insulin and arginine or levodopa.

Therapeutic options