TLR3 deficiency

Herpetic encephalopathy is a cerebral infection caused by herpes simplex virus type 1 (HSV1). This disease, which affects only a small minority of HSV1-infected individuals, could result from a genetic predisposition. A mutation in the UNC-93B gene, inducing impaired production of interferon, an anti-infectious factor necessary to fight the herpetic virus infection in nervous tissue, may be responsible for the disease. Another mutation was found in a gene encoding toll-like receptor 3 (TLR3).

Alternative names


Influenza associated encephalopathy

HSV encephalitis, Herpes simplex encephalitis, Herpes simplex neuroinvasion, Herpetic encephalopathy Herpetic encephalopathy, idiopathic


  • Defects of innate immune system, receptors and signaling components


Autosomal dominant