Hepatic veno-oclussive disease with immunodeficiency syndrome

Gene Information


HUGO name: SP110


  • FLJ22835, IFI41, IFI75, VODI


Reference sequences

Chromosomal location


Protein Information


Protein function:

Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (rare).


Isoform 3 interacts with HCV core protein.

Subcellular location:

Nucleus. Found in the nuclear body.

Post-translational modification:

Phosphorylated (isoform 2).

Alternative products:

Event=alternative splicing; named isoforms=5; name=1; isoid=q9hb58-1; sequence=displayed; name=2; synonyms=ifi75, 75; isoid=q9hb58-2; sequence=vsp_005992, vsp_006001, vsp_006002; name=3; synonyms=sp110b; isoid=q9hb58-3; sequence=vsp_005998, vsp_005999; name=4; synonyms=ifi41, 41; isoid=q9hb58-4; sequence=vsp_005991, vsp_005994, vsp_005995, vsp_005997, vsp_006000; name=5; isoid=q9hb58-5; sequence=vsp_005993, vsp_005996, vsp_005997, vsp_006000;


By interferon gamma and by all-trans retinoic acid.

Tissue specificity:

Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.


Contains 1 bromo domain.

Structures (PDB)


Expression pattern for human

Tissue Expression (%) Clones
bone_marrow 13.36 15:41353
tonsil 10.22 5:18016
spleen 7.78 10:47318
lymph 7.59 9:43667
lymph_node 6.65 15:83039
blood 5.40 9:61437
ovary 4.53 10:81370
mixed 4.21 33:288723
thymus 3.21 6:68776
bone 3.14 6:70388