Familial cold urticaria and Muckle-Wells syndrome

Most patients present at birth or during the first few months of life with rash. The attacks usually occur 1-2 hours following exposures to cold and last less than 24 hours. Other symptoms include fever, joint pain, myalgia, conjunctivitis, sweating, drowsiness, headache, extreme thirst, and nausea. Renal diseases is rare.

Therapeutic options

  • Supportive treatments with warming and non-steroidal anti-inflammatory drugs. High dose of corticosteroids can be effective. Other treatments include anabolic steroids and gold.
  • Mediterranean fever, familial, eMedicine

Research programs, clinical trials