STAT5b deficiency

Laron syndrome is an autosomal recessive disorder characterized by marked short stature, clinical hyposomatotropism, failure to generate somatomedin, or insulin-like growth factor-1 in response to growth hormone, and normal or increased levels of growth hormone. Patients have occasionally blue sclerae and hip degeneration. Laron syndrome is caused by dysfunction of the growth hormone receptor. There are two types: type I is associated with defects in growth hormone receptor while the second, type II, is apparently due to postreceptor defects in signal transduction to produce insulin-like growth factor-1 or possibly defects in its receptor.

Alternative names


Growth hormone insensitivity with immunodeficiency

Laron syndrome due to postreceptor defect


  • Defects of innate immune system, receptors and signaling components


Autosomal recessive


#245590 Laron syndrome, type II

*604260 Signal transducer and activator of transcription 5b; STAT5B

Cross references

Phenotypically related immunodeficiencies



Incidence is not known.