Gene UniProtKB Accession Amino acid substitution Position Original amino acid New amino acid Probability of pathogenicity Classification InSiGHT class MLH1 P40692 M1A 1 M A 0.076 Neutral MLH1 P40692 M1C 1 M C 0.042 Neutral MLH1 P40692 M1D 1 M D 0.166 Neutral MLH1 P40692 M1E 1 M E 0.066 Neutral MLH1 P40692 M1F 1 M F 0.23 Neutral MLH1 P40692 M1G 1 M G 0.122 Neutral MLH1 P40692 M1H 1 M H 0.058 Neutral MLH1 P40692 M1I 1 M I 0.098 Neutral MLH1 P40692 M1K 1 M K 0.086 Neutral MLH1 P40692 M1L 1 M L 0.096 Neutral MLH1 P40692 M1N 1 M N 0.198 Neutral MLH1 P40692 M1P 1 M P 0.284 Neutral MLH1 P40692 M1Q 1 M Q 0.068 Neutral MLH1 P40692 M1R 1 M R 0.186 Neutral MLH1 P40692 M1S 1 M S 0.164 Neutral MLH1 P40692 M1T 1 M T 0.146 Neutral MLH1 P40692 M1V 1 M V 0.126 Neutral MLH1 P40692 M1W 1 M W 0.478 Neutral MLH1 P40692 M1Y 1 M Y 0.386 Neutral MLH1 P40692 R10A 10 R A 0.11 Neutral MLH1 P40692 R10C 10 R C 0.654 Pathogenic MLH1 P40692 R10D 10 R D 0.634 Pathogenic MLH1 P40692 R10E 10 R E 0.544 Pathogenic MLH1 P40692 R10F 10 R F 0.916 Pathogenic MLH1 P40692 R10G 10 R G 0.2 Neutral MLH1 P40692 R10H 10 R H 0.486 Neutral MLH1 P40692 R10I 10 R I 0.894 Pathogenic MLH1 P40692 R10K 10 R K 0.038 Neutral MLH1 P40692 R10L 10 R L 0.874 Pathogenic MLH1 P40692 R10M 10 R M 0.596 Pathogenic MLH1 P40692 R10N 10 R N 0.496 Neutral MLH1 P40692 R10P 10 R P 0.142 Neutral MLH1 P40692 R10Q 10 R Q 0.436 Neutral MLH1 P40692 R10S 10 R S 0.43 Neutral MLH1 P40692 R10T 10 R T 0.536 Pathogenic MLH1 P40692 R10V 10 R V 0.814 Pathogenic MLH1 P40692 R10W 10 R W 0.898 Pathogenic MLH1 P40692 R10Y 10 R Y 0.876 Pathogenic MLH1 P40692 R100A 100 R A 0.586 Pathogenic MLH1 P40692 R100C 100 R C 0.966 Pathogenic MLH1 P40692 R100D 100 R D 0.782 Pathogenic MLH1 P40692 R100E 100 R E 0.2 Neutral MLH1 P40692 R100F 100 R F 0.976 Pathogenic MLH1 P40692 R100G 100 R G 0.438 Neutral MLH1 P40692 R100H 100 R H 0.456 Neutral MLH1 P40692 R100I 100 R I 0.978 Pathogenic MLH1 P40692 R100K 100 R K 0.82 Pathogenic MLH1 P40692 R100L 100 R L 0.99 Pathogenic MLH1 P40692 R100M 100 R M 0.784 Pathogenic MLH1 P40692 R100N 100 R N 0.708 Pathogenic MLH1 P40692 R100P 100 R P 0.99 Pathogenic 5 MLH1 P40692 R100Q 100 R Q 0.562 Pathogenic MLH1 P40692 R100S 100 R S 0.352 Neutral MLH1 P40692 R100T 100 R T 0.948 Pathogenic MLH1 P40692 R100V 100 R V 0.98 Pathogenic MLH1 P40692 R100W 100 R W 0.968 Pathogenic MLH1 P40692 R100Y 100 R Y 0.974 Pathogenic MLH1 P40692 G101A 101 G A 0.46 Neutral MLH1 P40692 G101C 101 G C 0.942 Pathogenic MLH1 P40692 G101D 101 G D 0.998 Pathogenic MLH1 P40692 G101E 101 G E 0.982 Pathogenic MLH1 P40692 G101F 101 G F 0.986 Pathogenic MLH1 P40692 G101H 101 G H 0.99 Pathogenic MLH1 P40692 G101I 101 G I 0.976 Pathogenic MLH1 P40692 G101K 101 G K 0.872 Pathogenic MLH1 P40692 G101L 101 G L 0.986 Pathogenic MLH1 P40692 G101M 101 G M 0.996 Pathogenic MLH1 P40692 G101N 101 G N 0.986 Pathogenic MLH1 P40692 G101P 101 G P 0.968 Pathogenic MLH1 P40692 G101Q 101 G Q 0.992 Pathogenic MLH1 P40692 G101R 101 G R 1 Pathogenic MLH1 P40692 G101S 101 G S 0.886 Pathogenic 4 MLH1 P40692 G101T 101 G T 0.858 Pathogenic MLH1 P40692 G101V 101 G V 0.988 Pathogenic MLH1 P40692 G101W 101 G W 0.982 Pathogenic MLH1 P40692 G101Y 101 G Y 0.962 Pathogenic MLH1 P40692 E102A 102 E A 0.812 Pathogenic MLH1 P40692 E102C 102 E C 0.756 Pathogenic MLH1 P40692 E102D 102 E D 0.892 Pathogenic 4 MLH1 P40692 E102F 102 E F 0.97 Pathogenic MLH1 P40692 E102G 102 E G 0.096 Neutral MLH1 P40692 E102H 102 E H 0.824 Pathogenic MLH1 P40692 E102I 102 E I 0.98 Pathogenic MLH1 P40692 E102K 102 E K 0.962 Pathogenic 5 MLH1 P40692 E102L 102 E L 0.974 Pathogenic MLH1 P40692 E102M 102 E M 0.914 Pathogenic MLH1 P40692 E102N 102 E N 0.77 Pathogenic MLH1 P40692 E102P 102 E P 0.936 Pathogenic MLH1 P40692 E102Q 102 E Q 0.346 Neutral MLH1 P40692 E102R 102 E R 0.93 Pathogenic MLH1 P40692 E102S 102 E S 0.9 Pathogenic MLH1 P40692 E102T 102 E T 0.354 Neutral MLH1 P40692 E102V 102 E V 0.918 Pathogenic MLH1 P40692 E102W 102 E W 0.984 Pathogenic MLH1 P40692 E102Y 102 E Y 0.964 Pathogenic MLH1 P40692 A103C 103 A C 0.598 Pathogenic MLH1 P40692 A103D 103 A D 0.928 Pathogenic MLH1 P40692 A103E 103 A E 0.916 Pathogenic MLH1 P40692 A103F 103 A F 0.974 Pathogenic MLH1 P40692 A103G 103 A G 0.754 Pathogenic MLH1 P40692 A103H 103 A H 0.898 Pathogenic MLH1 P40692 A103I 103 A I 0.886 Pathogenic MLH1 P40692 A103K 103 A K 0.74 Pathogenic MLH1 P40692 A103L 103 A L 0.988 Pathogenic MLH1 P40692 A103M 103 A M 0.876 Pathogenic MLH1 P40692 A103N 103 A N 0.852 Pathogenic MLH1 P40692 A103P 103 A P 0.974 Pathogenic MLH1 P40692 A103Q 103 A Q 0.848 Pathogenic MLH1 P40692 A103R 103 A R 0.964 Pathogenic MLH1 P40692 A103S 103 A S 0.494 Neutral MLH1 P40692 A103T 103 A T 0.786 Pathogenic MLH1 P40692 A103V 103 A V 0.798 Pathogenic MLH1 P40692 A103W 103 A W 0.984 Pathogenic MLH1 P40692 A103Y 103 A Y 0.966 Pathogenic MLH1 P40692 L104A 104 L A 0.706 Pathogenic MLH1 P40692 L104C 104 L C 0.82 Pathogenic MLH1 P40692 L104D 104 L D 0.888 Pathogenic MLH1 P40692 L104E 104 L E 0.868 Pathogenic MLH1 P40692 L104F 104 L F 0.68 Pathogenic MLH1 P40692 L104G 104 L G 0.828 Pathogenic MLH1 P40692 L104H 104 L H 0.908 Pathogenic MLH1 P40692 L104I 104 L I 0.936 Pathogenic MLH1 P40692 L104K 104 L K 0.724 Pathogenic MLH1 P40692 L104M 104 L M 0.356 Neutral MLH1 P40692 L104N 104 L N 0.764 Pathogenic MLH1 P40692 L104P 104 L P 0.994 Pathogenic MLH1 P40692 L104Q 104 L Q 0.266 Neutral MLH1 P40692 L104R 104 L R 0.978 Pathogenic MLH1 P40692 L104S 104 L S 0.646 Pathogenic MLH1 P40692 L104T 104 L T 0.602 Pathogenic MLH1 P40692 L104V 104 L V 0.47 Neutral MLH1 P40692 L104W 104 L W 0.892 Pathogenic MLH1 P40692 L104Y 104 L Y 0.88 Pathogenic MLH1 P40692 A105C 105 A C 0.96 Pathogenic MLH1 P40692 A105D 105 A D 0.948 Pathogenic MLH1 P40692 A105E 105 A E 0.96 Pathogenic MLH1 P40692 A105F 105 A F 0.992 Pathogenic MLH1 P40692 A105G 105 A G 0.77 Pathogenic MLH1 P40692 A105H 105 A H 0.928 Pathogenic MLH1 P40692 A105I 105 A I 0.966 Pathogenic MLH1 P40692 A105K 105 A K 0.744 Pathogenic MLH1 P40692 A105L 105 A L 0.996 Pathogenic MLH1 P40692 A105M 105 A M 0.9 Pathogenic MLH1 P40692 A105N 105 A N 0.864 Pathogenic MLH1 P40692 A105P 105 A P 0.974 Pathogenic MLH1 P40692 A105Q 105 A Q 0.876 Pathogenic MLH1 P40692 A105R 105 A R 0.97 Pathogenic MLH1 P40692 A105S 105 A S 0.12 Neutral MLH1 P40692 A105T 105 A T 0.33 Neutral MLH1 P40692 A105V 105 A V 0.934 Pathogenic MLH1 P40692 A105W 105 A W 0.992 Pathogenic MLH1 P40692 A105Y 105 A Y 0.97 Pathogenic MLH1 P40692 S106A 106 S A 0.858 Pathogenic MLH1 P40692 S106C 106 S C 0.582 Pathogenic MLH1 P40692 S106D 106 S D 0.898 Pathogenic MLH1 P40692 S106E 106 S E 0.712 Pathogenic MLH1 P40692 S106F 106 S F 0.982 Pathogenic MLH1 P40692 S106G 106 S G 0.236 Neutral MLH1 P40692 S106H 106 S H 0.972 Pathogenic MLH1 P40692 S106I 106 S I 0.886 Pathogenic MLH1 P40692 S106K 106 S K 0.716 Pathogenic MLH1 P40692 S106L 106 S L 0.926 Pathogenic MLH1 P40692 S106M 106 S M 0.998 Pathogenic MLH1 P40692 S106N 106 S N 0.88 Pathogenic MLH1 P40692 S106P 106 S P 0.648 Pathogenic MLH1 P40692 S106Q 106 S Q 0.942 Pathogenic MLH1 P40692 S106R 106 S R 0.734 Pathogenic MLH1 P40692 S106T 106 S T 0.856 Pathogenic MLH1 P40692 S106V 106 S V 0.964 Pathogenic MLH1 P40692 S106W 106 S W 0.97 Pathogenic MLH1 P40692 S106Y 106 S Y 0.974 Pathogenic MLH1 P40692 I107A 107 I A 0.208 Neutral MLH1 P40692 I107C 107 I C 0.602 Pathogenic MLH1 P40692 I107D 107 I D 0.744 Pathogenic MLH1 P40692 I107E 107 I E 0.754 Pathogenic MLH1 P40692 I107F 107 I F 0.962 Pathogenic MLH1 P40692 I107G 107 I G 0.792 Pathogenic MLH1 P40692 I107H 107 I H 0.848 Pathogenic MLH1 P40692 I107K 107 I K 0.846 Pathogenic MLH1 P40692 I107L 107 I L 0.18 Neutral MLH1 P40692 I107M 107 I M 0.178 Neutral MLH1 P40692 I107N 107 I N 0.77 Pathogenic MLH1 P40692 I107P 107 I P 0.502 Pathogenic MLH1 P40692 I107Q 107 I Q 0.784 Pathogenic MLH1 P40692 I107R 107 I R 0.874 Pathogenic 5 MLH1 P40692 I107S 107 I S 0.61 Pathogenic MLH1 P40692 I107T 107 I T 0.332 Neutral MLH1 P40692 I107V 107 I V 0.126 Neutral MLH1 P40692 I107W 107 I W 0.986 Pathogenic MLH1 P40692 I107Y 107 I Y 0.976 Pathogenic MLH1 P40692 S108A 108 S A 0.812 Pathogenic MLH1 P40692 S108C 108 S C 0.556 Pathogenic MLH1 P40692 S108D 108 S D 0.864 Pathogenic MLH1 P40692 S108E 108 S E 0.932 Pathogenic MLH1 P40692 S108F 108 S F 0.982 Pathogenic MLH1 P40692 S108G 108 S G 0.602 Pathogenic MLH1 P40692 S108H 108 S H 0.954 Pathogenic MLH1 P40692 S108I 108 S I 0.884 Pathogenic MLH1 P40692 S108K 108 S K 0.704 Pathogenic MLH1 P40692 S108L 108 S L 0.75 Pathogenic MLH1 P40692 S108M 108 S M 0.998 Pathogenic MLH1 P40692 S108N 108 S N 0.828 Pathogenic MLH1 P40692 S108P 108 S P 0.952 Pathogenic MLH1 P40692 S108Q 108 S Q 0.628 Pathogenic MLH1 P40692 S108R 108 S R 0.734 Pathogenic MLH1 P40692 S108T 108 S T 0.326 Neutral MLH1 P40692 S108V 108 S V 0.968 Pathogenic MLH1 P40692 S108W 108 S W 0.982 Pathogenic MLH1 P40692 S108Y 108 S Y 0.98 Pathogenic MLH1 P40692 H109A 109 H A 0.196 Neutral MLH1 P40692 H109C 109 H C 0.138 Neutral MLH1 P40692 H109D 109 H D 0.49 Neutral MLH1 P40692 H109E 109 H E 0.216 Neutral MLH1 P40692 H109F 109 H F 0.432 Neutral MLH1 P40692 H109G 109 H G 0.5 Pathogenic MLH1 P40692 H109I 109 H I 0.91 Pathogenic MLH1 P40692 H109K 109 H K 0.804 Pathogenic MLH1 P40692 H109L 109 H L 0.834 Pathogenic MLH1 P40692 H109M 109 H M 0.522 Pathogenic MLH1 P40692 H109N 109 H N 0.476 Neutral MLH1 P40692 H109P 109 H P 0.98 Pathogenic MLH1 P40692 H109Q 109 H Q 0.704 Pathogenic MLH1 P40692 H109R 109 H R 0.206 Neutral MLH1 P40692 H109S 109 H S 0.728 Pathogenic MLH1 P40692 H109T 109 H T 0.69 Pathogenic MLH1 P40692 H109V 109 H V 0.716 Pathogenic MLH1 P40692 H109W 109 H W 0.99 Pathogenic MLH1 P40692 H109Y 109 H Y 0.412 Neutral MLH1 P40692 L11A 11 L A 0.634 Pathogenic MLH1 P40692 L11C 11 L C 0.76 Pathogenic MLH1 P40692 L11D 11 L D 0.884 Pathogenic MLH1 P40692 L11E 11 L E 0.864 Pathogenic MLH1 P40692 L11F 11 L F 0.98 Pathogenic MLH1 P40692 L11G 11 L G 0.796 Pathogenic MLH1 P40692 L11H 11 L H 0.876 Pathogenic MLH1 P40692 L11I 11 L I 0.342 Neutral MLH1 P40692 L11K 11 L K 0.752 Pathogenic MLH1 P40692 L11M 11 L M 0.744 Pathogenic MLH1 P40692 L11N 11 L N 0.748 Pathogenic MLH1 P40692 L11P 11 L P 0.99 Pathogenic MLH1 P40692 L11Q 11 L Q 0.686 Pathogenic MLH1 P40692 L11R 11 L R 0.984 Pathogenic MLH1 P40692 L11S 11 L S 0.628 Pathogenic MLH1 P40692 L11T 11 L T 0.606 Pathogenic MLH1 P40692 L11V 11 L V 0.562 Pathogenic MLH1 P40692 L11W 11 L W 0.942 Pathogenic MLH1 P40692 L11Y 11 L Y 0.904 Pathogenic MLH1 P40692 V110A 110 V A 0.346 Neutral MLH1 P40692 V110C 110 V C 0.144 Neutral MLH1 P40692 V110D 110 V D 0.868 Pathogenic MLH1 P40692 V110E 110 V E 0.982 Pathogenic MLH1 P40692 V110F 110 V F 0.872 Pathogenic MLH1 P40692 V110G 110 V G 0.908 Pathogenic MLH1 P40692 V110H 110 V H 0.814 Pathogenic MLH1 P40692 V110I 110 V I 0.154 Neutral MLH1 P40692 V110K 110 V K 0.688 Pathogenic MLH1 P40692 V110L 110 V L 0.826 Pathogenic MLH1 P40692 V110M 110 V M 0.812 Pathogenic MLH1 P40692 V110N 110 V N 0.934 Pathogenic MLH1 P40692 V110P 110 V P 0.704 Pathogenic MLH1 P40692 V110Q 110 V Q 0.992 Pathogenic MLH1 P40692 V110R 110 V R 0.696 Pathogenic MLH1 P40692 V110S 110 V S 0.746 Pathogenic MLH1 P40692 V110T 110 V T 0.748 Pathogenic MLH1 P40692 V110W 110 V W 0.902 Pathogenic MLH1 P40692 V110Y 110 V Y 0.928 Pathogenic MLH1 P40692 A111C 111 A C 0.696 Pathogenic MLH1 P40692 A111D 111 A D 0.956 Pathogenic MLH1 P40692 A111E 111 A E 0.984 Pathogenic MLH1 P40692 A111F 111 A F 0.998 Pathogenic MLH1 P40692 A111G 111 A G 0.11 Neutral MLH1 P40692 A111H 111 A H 0.942 Pathogenic MLH1 P40692 A111I 111 A I 0.96 Pathogenic MLH1 P40692 A111K 111 A K 0.858 Pathogenic MLH1 P40692 A111L 111 A L 0.912 Pathogenic MLH1 P40692 A111M 111 A M 0.908 Pathogenic MLH1 P40692 A111N 111 A N 0.88 Pathogenic MLH1 P40692 A111P 111 A P 0.976 Pathogenic MLH1 P40692 A111Q 111 A Q 0.906 Pathogenic MLH1 P40692 A111R 111 A R 0.982 Pathogenic MLH1 P40692 A111S 111 A S 0.122 Neutral MLH1 P40692 A111T 111 A T 0.22 Neutral MLH1 P40692 A111V 111 A V 0.926 Pathogenic 4 MLH1 P40692 A111W 111 A W 0.996 Pathogenic MLH1 P40692 A111Y 111 A Y 0.966 Pathogenic MLH1 P40692 H112A 112 H A 0.146 Neutral MLH1 P40692 H112C 112 H C 0.492 Neutral MLH1 P40692 H112D 112 H D 0.464 Neutral MLH1 P40692 H112E 112 H E 0.632 Pathogenic MLH1 P40692 H112F 112 H F 0.782 Pathogenic MLH1 P40692 H112G 112 H G 0.172 Neutral MLH1 P40692 H112I 112 H I 0.822 Pathogenic MLH1 P40692 H112K 112 H K 0.356 Neutral MLH1 P40692 H112L 112 H L 0.322 Neutral MLH1 P40692 H112M 112 H M 0.66 Pathogenic MLH1 P40692 H112N 112 H N 0.094 Neutral MLH1 P40692 H112P 112 H P 0.932 Pathogenic MLH1 P40692 H112Q 112 H Q 0.116 Neutral MLH1 P40692 H112R 112 H R 0.114 Neutral MLH1 P40692 H112S 112 H S 0.622 Pathogenic MLH1 P40692 H112T 112 H T 0.314 Neutral MLH1 P40692 H112V 112 H V 0.552 Pathogenic MLH1 P40692 H112W 112 H W 0.95 Pathogenic MLH1 P40692 H112Y 112 H Y 0.794 Pathogenic MLH1 P40692 V113A 113 V A 0.17 Neutral MLH1 P40692 V113C 113 V C 0.462 Neutral MLH1 P40692 V113D 113 V D 0.654 Pathogenic MLH1 P40692 V113E 113 V E 0.756 Pathogenic MLH1 P40692 V113F 113 V F 0.6 Pathogenic MLH1 P40692 V113G 113 V G 0.668 Pathogenic MLH1 P40692 V113H 113 V H 0.606 Pathogenic MLH1 P40692 V113I 113 V I 0.236 Neutral MLH1 P40692 V113K 113 V K 0.614 Pathogenic MLH1 P40692 V113L 113 V L 0.146 Neutral MLH1 P40692 V113M 113 V M 0.13 Neutral MLH1 P40692 V113N 113 V N 0.494 Neutral MLH1 P40692 V113P 113 V P 0.846 Pathogenic MLH1 P40692 V113Q 113 V Q 0.532 Pathogenic MLH1 P40692 V113R 113 V R 0.714 Pathogenic MLH1 P40692 V113S 113 V S 0.516 Pathogenic MLH1 P40692 V113T 113 V T 0.488 Neutral MLH1 P40692 V113W 113 V W 0.848 Pathogenic MLH1 P40692 V113Y 113 V Y 0.646 Pathogenic MLH1 P40692 T114A 114 T A 0.058 Neutral MLH1 P40692 T114C 114 T C 0.238 Neutral MLH1 P40692 T114D 114 T D 0.606 Pathogenic MLH1 P40692 T114E 114 T E 0.358 Neutral MLH1 P40692 T114F 114 T F 0.784 Pathogenic MLH1 P40692 T114G 114 T G 0.124 Neutral MLH1 P40692 T114H 114 T H 0.462 Neutral MLH1 P40692 T114I 114 T I 0.466 Neutral MLH1 P40692 T114K 114 T K 0.126 Neutral MLH1 P40692 T114L 114 T L 0.44 Neutral MLH1 P40692 T114M 114 T M 0.54 Pathogenic MLH1 P40692 T114N 114 T N 0.018 Neutral MLH1 P40692 T114P 114 T P 0.506 Pathogenic MLH1 P40692 T114Q 114 T Q 0.096 Neutral MLH1 P40692 T114R 114 T R 0.578 Pathogenic MLH1 P40692 T114S 114 T S 0.012 Neutral MLH1 P40692 T114V 114 T V 0.726 Pathogenic MLH1 P40692 T114W 114 T W 0.932 Pathogenic MLH1 P40692 T114Y 114 T Y 0.928 Pathogenic MLH1 P40692 I115A 115 I A 0.21 Neutral MLH1 P40692 I115C 115 I C 0.628 Pathogenic MLH1 P40692 I115D 115 I D 0.782 Pathogenic MLH1 P40692 I115E 115 I E 0.786 Pathogenic MLH1 P40692 I115F 115 I F 0.584 Pathogenic MLH1 P40692 I115G 115 I G 0.82 Pathogenic MLH1 P40692 I115H 115 I H 0.846 Pathogenic MLH1 P40692 I115K 115 I K 0.86 Pathogenic MLH1 P40692 I115L 115 I L 0.356 Neutral MLH1 P40692 I115M 115 I M 0.67 Pathogenic MLH1 P40692 I115N 115 I N 0.804 Pathogenic MLH1 P40692 I115P 115 I P 0.93 Pathogenic MLH1 P40692 I115Q 115 I Q 0.812 Pathogenic MLH1 P40692 I115R 115 I R 0.892 Pathogenic MLH1 P40692 I115S 115 I S 0.62 Pathogenic MLH1 P40692 I115T 115 I T 0.17 Neutral MLH1 P40692 I115V 115 I V 0.278 Neutral MLH1 P40692 I115W 115 I W 0.96 Pathogenic MLH1 P40692 I115Y 115 I Y 0.954 Pathogenic MLH1 P40692 T116A 116 T A 0.24 Neutral MLH1 P40692 T116C 116 T C 0.588 Pathogenic MLH1 P40692 T116D 116 T D 0.598 Pathogenic MLH1 P40692 T116E 116 T E 0.478 Neutral MLH1 P40692 T116F 116 T F 0.782 Pathogenic MLH1 P40692 T116G 116 T G 0.33 Neutral MLH1 P40692 T116H 116 T H 0.648 Pathogenic MLH1 P40692 T116I 116 T I 0.156 Neutral MLH1 P40692 T116K 116 T K 0.626 Pathogenic MLH1 P40692 T116L 116 T L 0.124 Neutral MLH1 P40692 T116M 116 T M 0.524 Pathogenic MLH1 P40692 T116N 116 T N 0.432 Neutral MLH1 P40692 T116P 116 T P 0.686 Pathogenic 5 MLH1 P40692 T116Q 116 T Q 0.054 Neutral MLH1 P40692 T116R 116 T R 0.86 Pathogenic MLH1 P40692 T116S 116 T S 0.408 Neutral MLH1 P40692 T116V 116 T V 0.102 Neutral MLH1 P40692 T116W 116 T W 0.912 Pathogenic MLH1 P40692 T116Y 116 T Y 0.876 Pathogenic MLH1 P40692 T117A 117 T A 0.264 Neutral MLH1 P40692 T117C 117 T C 0.842 Pathogenic MLH1 P40692 T117D 117 T D 0.854 Pathogenic MLH1 P40692 T117E 117 T E 0.638 Pathogenic MLH1 P40692 T117F 117 T F 0.926 Pathogenic MLH1 P40692 T117G 117 T G 0.592 Pathogenic MLH1 P40692 T117H 117 T H 0.86 Pathogenic MLH1 P40692 T117I 117 T I 0.452 Neutral MLH1 P40692 T117K 117 T K 0.876 Pathogenic MLH1 P40692 T117L 117 T L 0.886 Pathogenic MLH1 P40692 T117M 117 T M 0.968 Pathogenic 5 MLH1 P40692 T117N 117 T N 0.774 Pathogenic MLH1 P40692 T117P 117 T P 0.922 Pathogenic MLH1 P40692 T117Q 117 T Q 0.78 Pathogenic MLH1 P40692 T117R 117 T R 0.71 Pathogenic MLH1 P40692 T117S 117 T S 0.074 Neutral MLH1 P40692 T117V 117 T V 0.894 Pathogenic MLH1 P40692 T117W 117 T W 0.994 Pathogenic MLH1 P40692 T117Y 117 T Y 0.994 Pathogenic MLH1 P40692 K118A 118 K A 0.542 Pathogenic MLH1 P40692 K118C 118 K C 0.446 Neutral MLH1 P40692 K118D 118 K D 0.23 Neutral MLH1 P40692 K118E 118 K E 0.144 Neutral MLH1 P40692 K118F 118 K F 0.954 Pathogenic MLH1 P40692 K118G 118 K G 0.54 Pathogenic MLH1 P40692 K118H 118 K H 0.734 Pathogenic MLH1 P40692 K118I 118 K I 0.312 Neutral MLH1 P40692 K118L 118 K L 0.974 Pathogenic MLH1 P40692 K118M 118 K M 0.494 Neutral MLH1 P40692 K118N 118 K N 0.67 Pathogenic MLH1 P40692 K118P 118 K P 0.916 Pathogenic MLH1 P40692 K118Q 118 K Q 0.734 Pathogenic MLH1 P40692 K118R 118 K R 0.126 Neutral MLH1 P40692 K118S 118 K S 0.704 Pathogenic MLH1 P40692 K118T 118 K T 0.166 Neutral MLH1 P40692 K118V 118 K V 0.87 Pathogenic MLH1 P40692 K118W 118 K W 0.992 Pathogenic MLH1 P40692 K118Y 118 K Y 0.982 Pathogenic MLH1 P40692 T119A 119 T A 0.648 Pathogenic MLH1 P40692 T119C 119 T C 0.888 Pathogenic MLH1 P40692 T119D 119 T D 0.902 Pathogenic MLH1 P40692 T119E 119 T E 0.94 Pathogenic MLH1 P40692 T119F 119 T F 0.936 Pathogenic MLH1 P40692 T119G 119 T G 0.206 Neutral MLH1 P40692 T119H 119 T H 0.886 Pathogenic MLH1 P40692 T119I 119 T I 0.93 Pathogenic MLH1 P40692 T119K 119 T K 0.518 Pathogenic MLH1 P40692 T119L 119 T L 0.612 Pathogenic MLH1 P40692 T119M 119 T M 0.978 Pathogenic MLH1 P40692 T119N 119 T N 0.834 Pathogenic MLH1 P40692 T119P 119 T P 0.65 Pathogenic MLH1 P40692 T119Q 119 T Q 0.27 Neutral MLH1 P40692 T119R 119 T R 0.63 Pathogenic MLH1 P40692 T119S 119 T S 0.75 Pathogenic MLH1 P40692 T119V 119 T V 0.382 Neutral MLH1 P40692 T119W 119 T W 0.994 Pathogenic MLH1 P40692 T119Y 119 T Y 0.994 Pathogenic MLH1 P40692 D12A 12 D A 0.132 Neutral MLH1 P40692 D12C 12 D C 0.762 Pathogenic MLH1 P40692 D12E 12 D E 0.03 Neutral MLH1 P40692 D12F 12 D F 0.94 Pathogenic MLH1 P40692 D12G 12 D G 0.392 Neutral MLH1 P40692 D12H 12 D H 0.084 Neutral MLH1 P40692 D12I 12 D I 0.91 Pathogenic MLH1 P40692 D12K 12 D K 0.376 Neutral MLH1 P40692 D12L 12 D L 0.916 Pathogenic MLH1 P40692 D12M 12 D M 0.818 Pathogenic MLH1 P40692 D12N 12 D N 0.074 Neutral MLH1 P40692 D12P 12 D P 0.398 Neutral MLH1 P40692 D12Q 12 D Q 0.028 Neutral MLH1 P40692 D12R 12 D R 0.764 Pathogenic MLH1 P40692 D12S 12 D S 0.012 Neutral MLH1 P40692 D12T 12 D T 0.31 Neutral MLH1 P40692 D12V 12 D V 0.938 Pathogenic MLH1 P40692 D12W 12 D W 0.94 Pathogenic MLH1 P40692 D12Y 12 D Y 0.968 Pathogenic MLH1 P40692 A120C 120 A C 0.682 Pathogenic MLH1 P40692 A120D 120 A D 0.91 Pathogenic MLH1 P40692 A120E 120 A E 0.604 Pathogenic MLH1 P40692 A120F 120 A F 0.968 Pathogenic MLH1 P40692 A120G 120 A G 0.462 Neutral MLH1 P40692 A120H 120 A H 0.872 Pathogenic MLH1 P40692 A120I 120 A I 0.942 Pathogenic MLH1 P40692 A120K 120 A K 0.55 Pathogenic MLH1 P40692 A120L 120 A L 0.922 Pathogenic MLH1 P40692 A120M 120 A M 0.822 Pathogenic MLH1 P40692 A120N 120 A N 0.604 Pathogenic MLH1 P40692 A120P 120 A P 0.28 Neutral MLH1 P40692 A120Q 120 A Q 0.612 Pathogenic MLH1 P40692 A120R 120 A R 0.632 Pathogenic MLH1 P40692 A120S 120 A S 0.054 Neutral MLH1 P40692 A120T 120 A T 0.208 Neutral MLH1 P40692 A120V 120 A V 0.148 Neutral MLH1 P40692 A120W 120 A W 0.954 Pathogenic MLH1 P40692 A120Y 120 A Y 0.94 Pathogenic MLH1 P40692 D121A 121 D A 0.148 Neutral MLH1 P40692 D121C 121 D C 0.716 Pathogenic MLH1 P40692 D121E 121 D E 0.048 Neutral MLH1 P40692 D121F 121 D F 0.92 Pathogenic MLH1 P40692 D121G 121 D G 0.074 Neutral MLH1 P40692 D121H 121 D H 0.106 Neutral MLH1 P40692 D121I 121 D I 0.876 Pathogenic MLH1 P40692 D121K 121 D K 0.086 Neutral MLH1 P40692 D121L 121 D L 0.8 Pathogenic MLH1 P40692 D121M 121 D M 0.778 Pathogenic MLH1 P40692 D121N 121 D N 0.03 Neutral MLH1 P40692 D121P 121 D P 0.798 Pathogenic MLH1 P40692 D121Q 121 D Q 0.49 Neutral MLH1 P40692 D121R 121 D R 0.634 Pathogenic MLH1 P40692 D121S 121 D S 0.026 Neutral MLH1 P40692 D121T 121 D T 0.078 Neutral MLH1 P40692 D121V 121 D V 0.902 Pathogenic MLH1 P40692 D121W 121 D W 0.968 Pathogenic MLH1 P40692 D121Y 121 D Y 0.964 Pathogenic MLH1 P40692 G122A 122 G A 0.04 Neutral MLH1 P40692 G122C 122 G C 0.678 Pathogenic MLH1 P40692 G122D 122 G D 0.38 Neutral MLH1 P40692 G122E 122 G E 0.484 Neutral MLH1 P40692 G122F 122 G F 0.94 Pathogenic MLH1 P40692 G122H 122 G H 0.936 Pathogenic MLH1 P40692 G122I 122 G I 0.908 Pathogenic MLH1 P40692 G122K 122 G K 0.906 Pathogenic MLH1 P40692 G122L 122 G L 0.734 Pathogenic MLH1 P40692 G122M 122 G M 0.894 Pathogenic MLH1 P40692 G122N 122 G N 0.516 Pathogenic MLH1 P40692 G122P 122 G P 0.908 Pathogenic MLH1 P40692 G122Q 122 G Q 0.47 Neutral MLH1 P40692 G122R 122 G R 0.956 Pathogenic MLH1 P40692 G122S 122 G S 0.072 Neutral MLH1 P40692 G122T 122 G T 0.816 Pathogenic MLH1 P40692 G122V 122 G V 0.916 Pathogenic MLH1 P40692 G122W 122 G W 0.932 Pathogenic MLH1 P40692 G122Y 122 G Y 0.922 Pathogenic MLH1 P40692 K123A 123 K A 0.04 Neutral MLH1 P40692 K123C 123 K C 0.094 Neutral MLH1 P40692 K123D 123 K D 0.006 Neutral MLH1 P40692 K123E 123 K E 0.006 Neutral MLH1 P40692 K123F 123 K F 0.124 Neutral MLH1 P40692 K123G 123 K G 0.058 Neutral MLH1 P40692 K123H 123 K H 0.094 Neutral MLH1 P40692 K123I 123 K I 0.078 Neutral MLH1 P40692 K123L 123 K L 0.056 Neutral MLH1 P40692 K123M 123 K M 0.168 Neutral MLH1 P40692 K123N 123 K N 0.012 Neutral MLH1 P40692 K123P 123 K P 0.04 Neutral MLH1 P40692 K123Q 123 K Q 0.012 Neutral MLH1 P40692 K123R 123 K R 0.008 Neutral MLH1 P40692 K123S 123 K S 0.022 Neutral MLH1 P40692 K123T 123 K T 0.03 Neutral MLH1 P40692 K123V 123 K V 0.064 Neutral MLH1 P40692 K123W 123 K W 0.76 Pathogenic MLH1 P40692 K123Y 123 K Y 0.65 Pathogenic MLH1 P40692 C124A 124 C A 0.118 Neutral MLH1 P40692 C124D 124 C D 0.844 Pathogenic MLH1 P40692 C124E 124 C E 0.828 Pathogenic MLH1 P40692 C124F 124 C F 0.98 Pathogenic MLH1 P40692 C124G 124 C G 0.832 Pathogenic MLH1 P40692 C124H 124 C H 0.446 Neutral MLH1 P40692 C124I 124 C I 0.804 Pathogenic MLH1 P40692 C124K 124 C K 0.808 Pathogenic MLH1 P40692 C124L 124 C L 0.368 Neutral MLH1 P40692 C124M 124 C M 0.646 Pathogenic MLH1 P40692 C124N 124 C N 0.664 Pathogenic MLH1 P40692 C124P 124 C P 0.95 Pathogenic MLH1 P40692 C124Q 124 C Q 0.41 Neutral MLH1 P40692 C124R 124 C R 0.978 Pathogenic MLH1 P40692 C124S 124 C S 0.124 Neutral MLH1 P40692 C124T 124 C T 0.356 Neutral MLH1 P40692 C124V 124 C V 0.302 Neutral MLH1 P40692 C124W 124 C W 0.98 Pathogenic MLH1 P40692 C124Y 124 C Y 0.778 Pathogenic MLH1 P40692 A125C 125 A C 0.976 Pathogenic MLH1 P40692 A125D 125 A D 0.954 Pathogenic MLH1 P40692 A125E 125 A E 0.976 Pathogenic MLH1 P40692 A125F 125 A F 0.994 Pathogenic MLH1 P40692 A125G 125 A G 0.1 Neutral MLH1 P40692 A125H 125 A H 0.942 Pathogenic MLH1 P40692 A125I 125 A I 0.96 Pathogenic MLH1 P40692 A125K 125 A K 0.972 Pathogenic MLH1 P40692 A125L 125 A L 1 Pathogenic MLH1 P40692 A125M 125 A M 0.908 Pathogenic MLH1 P40692 A125N 125 A N 0.54 Pathogenic MLH1 P40692 A125P 125 A P 0.86 Pathogenic MLH1 P40692 A125Q 125 A Q 0.9 Pathogenic MLH1 P40692 A125R 125 A R 0.982 Pathogenic MLH1 P40692 A125S 125 A S 0.202 Neutral MLH1 P40692 A125T 125 A T 0.9 Pathogenic MLH1 P40692 A125V 125 A V 0.928 Pathogenic MLH1 P40692 A125W 125 A W 0.996 Pathogenic MLH1 P40692 A125Y 125 A Y 0.966 Pathogenic MLH1 P40692 Y126A 126 Y A 0.196 Neutral MLH1 P40692 Y126C 126 Y C 0.354 Neutral MLH1 P40692 Y126D 126 Y D 0.564 Pathogenic MLH1 P40692 Y126E 126 Y E 0.55 Pathogenic MLH1 P40692 Y126F 126 Y F 0.026 Neutral MLH1 P40692 Y126G 126 Y G 0.282 Neutral MLH1 P40692 Y126H 126 Y H 0.03 Neutral MLH1 P40692 Y126I 126 Y I 0.476 Neutral MLH1 P40692 Y126K 126 Y K 0.382 Neutral MLH1 P40692 Y126L 126 Y L 0.108 Neutral MLH1 P40692 Y126M 126 Y M 0.206 Neutral MLH1 P40692 Y126N 126 Y N 0.406 Neutral MLH1 P40692 Y126P 126 Y P 0.418 Neutral MLH1 P40692 Y126Q 126 Y Q 0.272 Neutral MLH1 P40692 Y126R 126 Y R 0.594 Pathogenic MLH1 P40692 Y126S 126 Y S 0.238 Neutral MLH1 P40692 Y126T 126 Y T 0.36 Neutral MLH1 P40692 Y126V 126 Y V 0.138 Neutral MLH1 P40692 Y126W 126 Y W 0.058 Neutral MLH1 P40692 R127A 127 R A 0.288 Neutral MLH1 P40692 R127C 127 R C 0.41 Neutral MLH1 P40692 R127D 127 R D 0.644 Pathogenic MLH1 P40692 R127E 127 R E 0.172 Neutral MLH1 P40692 R127F 127 R F 0.916 Pathogenic MLH1 P40692 R127G 127 R G 0.13 Neutral MLH1 P40692 R127H 127 R H 0.434 Neutral MLH1 P40692 R127I 127 R I 0.9 Pathogenic MLH1 P40692 R127K 127 R K 0.644 Pathogenic 4 MLH1 P40692 R127L 127 R L 0.88 Pathogenic MLH1 P40692 R127M 127 R M 0.66 Pathogenic MLH1 P40692 R127N 127 R N 0.544 Pathogenic MLH1 P40692 R127P 127 R P 0.464 Neutral MLH1 P40692 R127Q 127 R Q 0.106 Neutral MLH1 P40692 R127S 127 R S 0.308 Neutral MLH1 P40692 R127T 127 R T 0.618 Pathogenic MLH1 P40692 R127V 127 R V 0.646 Pathogenic MLH1 P40692 R127W 127 R W 0.888 Pathogenic MLH1 P40692 R127Y 127 R Y 0.874 Pathogenic MLH1 P40692 A128C 128 A C 0.69 Pathogenic MLH1 P40692 A128D 128 A D 0.948 Pathogenic MLH1 P40692 A128E 128 A E 0.976 Pathogenic MLH1 P40692 A128F 128 A F 0.996 Pathogenic MLH1 P40692 A128G 128 A G 0.104 Neutral MLH1 P40692 A128H 128 A H 0.936 Pathogenic MLH1 P40692 A128I 128 A I 0.958 Pathogenic MLH1 P40692 A128K 128 A K 0.974 Pathogenic MLH1 P40692 A128L 128 A L 1 Pathogenic MLH1 P40692 A128M 128 A M 0.902 Pathogenic MLH1 P40692 A128N 128 A N 0.648 Pathogenic MLH1 P40692 A128P 128 A P 0.974 Pathogenic 5 MLH1 P40692 A128Q 128 A Q 0.902 Pathogenic MLH1 P40692 A128R 128 A R 0.65 Pathogenic MLH1 P40692 A128S 128 A S 0.152 Neutral MLH1 P40692 A128T 128 A T 0.238 Neutral MLH1 P40692 A128V 128 A V 0.436 Neutral MLH1 P40692 A128W 128 A W 0.996 Pathogenic MLH1 P40692 A128Y 128 A Y 0.964 Pathogenic MLH1 P40692 S129A 129 S A 0.05 Neutral MLH1 P40692 S129C 129 S C 0.004 Neutral MLH1 P40692 S129D 129 S D 0.154 Neutral MLH1 P40692 S129E 129 S E 0.3 Neutral MLH1 P40692 S129F 129 S F 0.44 Neutral MLH1 P40692 S129G 129 S G 0.15 Neutral MLH1 P40692 S129H 129 S H 0.344 Neutral MLH1 P40692 S129I 129 S I 0.328 Neutral MLH1 P40692 S129K 129 S K 0.302 Neutral MLH1 P40692 S129L 129 S L 0.066 Neutral MLH1 P40692 S129M 129 S M 0.548 Pathogenic MLH1 P40692 S129N 129 S N 0.008 Neutral MLH1 P40692 S129P 129 S P 0.264 Neutral MLH1 P40692 S129Q 129 S Q 0.324 Neutral MLH1 P40692 S129R 129 S R 0.47 Neutral MLH1 P40692 S129T 129 S T 0.024 Neutral MLH1 P40692 S129V 129 S V 0.054 Neutral MLH1 P40692 S129W 129 S W 0.834 Pathogenic MLH1 P40692 S129Y 129 S Y 0.566 Pathogenic MLH1 P40692 E13A 13 E A 0.228 Neutral MLH1 P40692 E13C 13 E C 0.488 Neutral MLH1 P40692 E13D 13 E D 0.216 Neutral MLH1 P40692 E13F 13 E F 0.882 Pathogenic MLH1 P40692 E13G 13 E G 0.212 Neutral MLH1 P40692 E13H 13 E H 0.612 Pathogenic MLH1 P40692 E13I 13 E I 0.938 Pathogenic MLH1 P40692 E13K 13 E K 0.058 Neutral MLH1 P40692 E13L 13 E L 0.918 Pathogenic MLH1 P40692 E13M 13 E M 0.718 Pathogenic MLH1 P40692 E13N 13 E N 0.344 Neutral MLH1 P40692 E13P 13 E P 0.104 Neutral MLH1 P40692 E13Q 13 E Q 0.012 Neutral MLH1 P40692 E13R 13 E R 0.588 Pathogenic MLH1 P40692 E13S 13 E S 0.526 Pathogenic MLH1 P40692 E13T 13 E T 0.246 Neutral MLH1 P40692 E13V 13 E V 0.722 Pathogenic MLH1 P40692 E13W 13 E W 0.972 Pathogenic MLH1 P40692 E13Y 13 E Y 0.92 Pathogenic MLH1 P40692 Y130A 130 Y A 0.384 Neutral MLH1 P40692 Y130C 130 Y C 0.614 Pathogenic MLH1 P40692 Y130D 130 Y D 0.786 Pathogenic MLH1 P40692 Y130E 130 Y E 0.694 Pathogenic MLH1 P40692 Y130F 130 Y F 0.15 Neutral MLH1 P40692 Y130G 130 Y G 0.27 Neutral MLH1 P40692 Y130H 130 Y H 0.542 Pathogenic MLH1 P40692 Y130I 130 Y I 0.306 Neutral MLH1 P40692 Y130K 130 Y K 0.416 Neutral MLH1 P40692 Y130L 130 Y L 0.232 Neutral MLH1 P40692 Y130M 130 Y M 0.64 Pathogenic MLH1 P40692 Y130N 130 Y N 0.278 Neutral MLH1 P40692 Y130P 130 Y P 0.758 Pathogenic MLH1 P40692 Y130Q 130 Y Q 0.578 Pathogenic MLH1 P40692 Y130R 130 Y R 0.716 Pathogenic MLH1 P40692 Y130S 130 Y S 0.43 Neutral MLH1 P40692 Y130T 130 Y T 0.606 Pathogenic MLH1 P40692 Y130V 130 Y V 0.76 Pathogenic MLH1 P40692 Y130W 130 Y W 0.86 Pathogenic MLH1 P40692 S131A 131 S A 0.012 Neutral MLH1 P40692 S131C 131 S C 0.002 Neutral MLH1 P40692 S131D 131 S D 0.09 Neutral MLH1 P40692 S131E 131 S E 0.254 Neutral MLH1 P40692 S131F 131 S F 0.538 Pathogenic MLH1 P40692 S131G 131 S G 0.002 Neutral MLH1 P40692 S131H 131 S H 0.342 Neutral MLH1 P40692 S131I 131 S I 0.224 Neutral MLH1 P40692 S131K 131 S K 0.282 Neutral MLH1 P40692 S131L 131 S L 0.048 Neutral MLH1 P40692 S131M 131 S M 0.488 Neutral MLH1 P40692 S131N 131 S N 0.074 Neutral MLH1 P40692 S131P 131 S P 0.228 Neutral MLH1 P40692 S131Q 131 S Q 0.286 Neutral MLH1 P40692 S131R 131 S R 0.276 Neutral MLH1 P40692 S131T 131 S T 0.024 Neutral MLH1 P40692 S131V 131 S V 0.054 Neutral MLH1 P40692 S131W 131 S W 0.782 Pathogenic MLH1 P40692 S131Y 131 S Y 0.742 Pathogenic MLH1 P40692 D132A 132 D A 0.196 Neutral MLH1 P40692 D132C 132 D C 0.718 Pathogenic MLH1 P40692 D132E 132 D E 0.198 Neutral MLH1 P40692 D132F 132 D F 0.908 Pathogenic MLH1 P40692 D132G 132 D G 0.164 Neutral MLH1 P40692 D132H 132 D H 0.314 Neutral 1 MLH1 P40692 D132I 132 D I 0.9 Pathogenic MLH1 P40692 D132K 132 D K 0.746 Pathogenic MLH1 P40692 D132L 132 D L 0.462 Neutral MLH1 P40692 D132M 132 D M 0.812 Pathogenic MLH1 P40692 D132N 132 D N 0.068 Neutral MLH1 P40692 D132P 132 D P 0.792 Pathogenic MLH1 P40692 D132Q 132 D Q 0.228 Neutral MLH1 P40692 D132R 132 D R 0.596 Pathogenic MLH1 P40692 D132S 132 D S 0.12 Neutral MLH1 P40692 D132T 132 D T 0.604 Pathogenic MLH1 P40692 D132V 132 D V 0.914 Pathogenic MLH1 P40692 D132W 132 D W 0.924 Pathogenic MLH1 P40692 D132Y 132 D Y 0.914 Pathogenic MLH1 P40692 G133A 133 G A 0.908 Pathogenic MLH1 P40692 G133C 133 G C 0.936 Pathogenic MLH1 P40692 G133D 133 G D 0.972 Pathogenic MLH1 P40692 G133E 133 G E 0.808 Pathogenic MLH1 P40692 G133F 133 G F 0.93 Pathogenic MLH1 P40692 G133H 133 G H 0.992 Pathogenic MLH1 P40692 G133I 133 G I 0.978 Pathogenic MLH1 P40692 G133K 133 G K 0.902 Pathogenic MLH1 P40692 G133L 133 G L 0.988 Pathogenic MLH1 P40692 G133M 133 G M 0.994 Pathogenic MLH1 P40692 G133N 133 G N 0.646 Pathogenic MLH1 P40692 G133P 133 G P 0.982 Pathogenic MLH1 P40692 G133Q 133 G Q 0.98 Pathogenic MLH1 P40692 G133R 133 G R 0.88 Pathogenic MLH1 P40692 G133S 133 G S 0.294 Neutral MLH1 P40692 G133T 133 G T 0.824 Pathogenic MLH1 P40692 G133V 133 G V 0.99 Pathogenic MLH1 P40692 G133W 133 G W 0.984 Pathogenic MLH1 P40692 G133Y 133 G Y 0.984 Pathogenic MLH1 P40692 K134A 134 K A 0.076 Neutral MLH1 P40692 K134C 134 K C 0.21 Neutral MLH1 P40692 K134D 134 K D 0.328 Neutral MLH1 P40692 K134E 134 K E 0.026 Neutral MLH1 P40692 K134F 134 K F 0.86 Pathogenic MLH1 P40692 K134G 134 K G 0.362 Neutral MLH1 P40692 K134H 134 K H 0.154 Neutral MLH1 P40692 K134I 134 K I 0.74 Pathogenic MLH1 P40692 K134L 134 K L 0.218 Neutral MLH1 P40692 K134M 134 K M 0.542 Pathogenic MLH1 P40692 K134N 134 K N 0.052 Neutral MLH1 P40692 K134P 134 K P 0.834 Pathogenic MLH1 P40692 K134Q 134 K Q 0.086 Neutral MLH1 P40692 K134R 134 K R 0.038 Neutral MLH1 P40692 K134S 134 K S 0.026 Neutral MLH1 P40692 K134T 134 K T 0.278 Neutral MLH1 P40692 K134V 134 K V 0.098 Neutral MLH1 P40692 K134W 134 K W 0.972 Pathogenic MLH1 P40692 K134Y 134 K Y 0.932 Pathogenic MLH1 P40692 L135A 135 L A 0.108 Neutral MLH1 P40692 L135C 135 L C 0.144 Neutral MLH1 P40692 L135D 135 L D 0.252 Neutral MLH1 P40692 L135E 135 L E 0.228 Neutral MLH1 P40692 L135F 135 L F 0.382 Neutral MLH1 P40692 L135G 135 L G 0.066 Neutral MLH1 P40692 L135H 135 L H 0.132 Neutral MLH1 P40692 L135I 135 L I 0.002 Neutral MLH1 P40692 L135K 135 L K 0.03 Neutral MLH1 P40692 L135M 135 L M 0.012 Neutral MLH1 P40692 L135N 135 L N 0.248 Neutral MLH1 P40692 L135P 135 L P 0.116 Neutral MLH1 P40692 L135Q 135 L Q 0.11 Neutral MLH1 P40692 L135R 135 L R 0.508 Pathogenic MLH1 P40692 L135S 135 L S 0.196 Neutral MLH1 P40692 L135T 135 L T 0.046 Neutral MLH1 P40692 L135V 135 L V 0.19 Neutral MLH1 P40692 L135W 135 L W 0.572 Pathogenic MLH1 P40692 L135Y 135 L Y 0.532 Pathogenic MLH1 P40692 K136A 136 K A 0.112 Neutral MLH1 P40692 K136C 136 K C 0.084 Neutral MLH1 P40692 K136D 136 K D 0.09 Neutral MLH1 P40692 K136E 136 K E 0.006 Neutral MLH1 P40692 K136F 136 K F 0.426 Neutral MLH1 P40692 K136G 136 K G 0.054 Neutral MLH1 P40692 K136H 136 K H 0.11 Neutral MLH1 P40692 K136I 136 K I 0.458 Neutral MLH1 P40692 K136L 136 K L 0.066 Neutral MLH1 P40692 K136M 136 K M 0.258 Neutral MLH1 P40692 K136N 136 K N 0.012 Neutral MLH1 P40692 K136P 136 K P 0.038 Neutral MLH1 P40692 K136Q 136 K Q 0.014 Neutral MLH1 P40692 K136R 136 K R 0.06 Neutral MLH1 P40692 K136S 136 K S 0.018 Neutral MLH1 P40692 K136T 136 K T 0.044 Neutral MLH1 P40692 K136V 136 K V 0.06 Neutral MLH1 P40692 K136W 136 K W 0.746 Pathogenic MLH1 P40692 K136Y 136 K Y 0.632 Pathogenic MLH1 P40692 A137C 137 A C 0.666 Pathogenic MLH1 P40692 A137D 137 A D 0.6 Pathogenic MLH1 P40692 A137E 137 A E 0.532 Pathogenic MLH1 P40692 A137F 137 A F 0.91 Pathogenic MLH1 P40692 A137G 137 A G 0.036 Neutral MLH1 P40692 A137H 137 A H 0.478 Neutral MLH1 P40692 A137I 137 A I 0.918 Pathogenic MLH1 P40692 A137K 137 A K 0.662 Pathogenic MLH1 P40692 A137L 137 A L 0.878 Pathogenic MLH1 P40692 A137M 137 A M 0.756 Pathogenic MLH1 P40692 A137N 137 A N 0.526 Pathogenic MLH1 P40692 A137P 137 A P 0.11 Neutral MLH1 P40692 A137Q 137 A Q 0.502 Pathogenic MLH1 P40692 A137R 137 A R 0.856 Pathogenic MLH1 P40692 A137S 137 A S 0.034 Neutral MLH1 P40692 A137T 137 A T 0.06 Neutral MLH1 P40692 A137V 137 A V 0.112 Neutral MLH1 P40692 A137W 137 A W 0.904 Pathogenic MLH1 P40692 A137Y 137 A Y 0.562 Pathogenic MLH1 P40692 P138A 138 P A 0.078 Neutral MLH1 P40692 P138C 138 P C 0.546 Pathogenic MLH1 P40692 P138D 138 P D 0.056 Neutral MLH1 P40692 P138E 138 P E 0.142 Neutral MLH1 P40692 P138F 138 P F 0.9 Pathogenic MLH1 P40692 P138G 138 P G 0.252 Neutral MLH1 P40692 P138H 138 P H 0.8 Pathogenic MLH1 P40692 P138I 138 P I 0.674 Pathogenic MLH1 P40692 P138K 138 P K 0.12 Neutral MLH1 P40692 P138L 138 P L 0.62 Pathogenic MLH1 P40692 P138M 138 P M 0.666 Pathogenic MLH1 P40692 P138N 138 P N 0.158 Neutral MLH1 P40692 P138Q 138 P Q 0.14 Neutral MLH1 P40692 P138R 138 P R 0.74 Pathogenic MLH1 P40692 P138S 138 P S 0.042 Neutral MLH1 P40692 P138T 138 P T 0.522 Pathogenic MLH1 P40692 P138V 138 P V 0.328 Neutral MLH1 P40692 P138W 138 P W 0.882 Pathogenic MLH1 P40692 P138Y 138 P Y 0.864 Pathogenic MLH1 P40692 P139A 139 P A 0.168 Neutral MLH1 P40692 P139C 139 P C 0.516 Pathogenic MLH1 P40692 P139D 139 P D 0.776 Pathogenic MLH1 P40692 P139E 139 P E 0.972 Pathogenic MLH1 P40692 P139F 139 P F 0.998 Pathogenic MLH1 P40692 P139G 139 P G 0.512 Pathogenic MLH1 P40692 P139H 139 P H 0.982 Pathogenic MLH1 P40692 P139I 139 P I 0.318 Neutral MLH1 P40692 P139K 139 P K 0.962 Pathogenic MLH1 P40692 P139L 139 P L 0.308 Neutral MLH1 P40692 P139M 139 P M 0.964 Pathogenic MLH1 P40692 P139N 139 P N 0.63 Pathogenic MLH1 P40692 P139Q 139 P Q 0.862 Pathogenic MLH1 P40692 P139R 139 P R 0.986 Pathogenic MLH1 P40692 P139S 139 P S 0.098 Neutral MLH1 P40692 P139T 139 P T 0.69 Pathogenic MLH1 P40692 P139V 139 P V 0.146 Neutral MLH1 P40692 P139W 139 P W 0.946 Pathogenic MLH1 P40692 P139Y 139 P Y 0.946 Pathogenic MLH1 P40692 T14A 14 T A 0.004 Neutral MLH1 P40692 T14C 14 T C 0.038 Neutral MLH1 P40692 T14D 14 T D 0.032 Neutral MLH1 P40692 T14E 14 T E 0.046 Neutral MLH1 P40692 T14F 14 T F 0.5 Pathogenic MLH1 P40692 T14G 14 T G 0.13 Neutral MLH1 P40692 T14H 14 T H 0.258 Neutral MLH1 P40692 T14I 14 T I 0.084 Neutral MLH1 P40692 T14K 14 T K 0.018 Neutral MLH1 P40692 T14L 14 T L 0.136 Neutral MLH1 P40692 T14M 14 T M 0.34 Neutral MLH1 P40692 T14N 14 T N 0.002 Neutral MLH1 P40692 T14P 14 T P 0.304 Neutral MLH1 P40692 T14Q 14 T Q 0.068 Neutral MLH1 P40692 T14R 14 T R 0.534 Pathogenic MLH1 P40692 T14S 14 T S 0.002 Neutral MLH1 P40692 T14V 14 T V 0.028 Neutral MLH1 P40692 T14W 14 T W 0.81 Pathogenic MLH1 P40692 T14Y 14 T Y 0.772 Pathogenic MLH1 P40692 K140A 140 K A 0.124 Neutral MLH1 P40692 K140C 140 K C 0.396 Neutral MLH1 P40692 K140D 140 K D 0.546 Pathogenic MLH1 P40692 K140E 140 K E 0.238 Neutral MLH1 P40692 K140F 140 K F 0.86 Pathogenic MLH1 P40692 K140G 140 K G 0.556 Pathogenic MLH1 P40692 K140H 140 K H 0.132 Neutral MLH1 P40692 K140I 140 K I 0.482 Neutral MLH1 P40692 K140L 140 K L 0.466 Neutral MLH1 P40692 K140M 140 K M 0.736 Pathogenic MLH1 P40692 K140N 140 K N 0.122 Neutral MLH1 P40692 K140P 140 K P 0.846 Pathogenic MLH1 P40692 K140Q 140 K Q 0.11 Neutral MLH1 P40692 K140R 140 K R 0.124 Neutral MLH1 P40692 K140S 140 K S 0.21 Neutral MLH1 P40692 K140T 140 K T 0.144 Neutral MLH1 P40692 K140V 140 K V 0.236 Neutral MLH1 P40692 K140W 140 K W 0.952 Pathogenic MLH1 P40692 K140Y 140 K Y 0.924 Pathogenic MLH1 P40692 P141A 141 P A 0.158 Neutral MLH1 P40692 P141C 141 P C 0.92 Pathogenic MLH1 P40692 P141D 141 P D 0.776 Pathogenic MLH1 P40692 P141E 141 P E 0.978 Pathogenic MLH1 P40692 P141F 141 P F 0.986 Pathogenic MLH1 P40692 P141G 141 P G 0.11 Neutral MLH1 P40692 P141H 141 P H 0.992 Pathogenic MLH1 P40692 P141I 141 P I 0.876 Pathogenic MLH1 P40692 P141K 141 P K 0.588 Pathogenic MLH1 P40692 P141L 141 P L 0.282 Neutral MLH1 P40692 P141M 141 P M 0.968 Pathogenic MLH1 P40692 P141N 141 P N 0.174 Neutral MLH1 P40692 P141Q 141 P Q 0.254 Neutral MLH1 P40692 P141R 141 P R 0.516 Pathogenic MLH1 P40692 P141S 141 P S 0.096 Neutral MLH1 P40692 P141T 141 P T 0.652 Pathogenic MLH1 P40692 P141V 141 P V 0.812 Pathogenic MLH1 P40692 P141W 141 P W 0.9 Pathogenic MLH1 P40692 P141Y 141 P Y 0.884 Pathogenic MLH1 P40692 C142A 142 C A 0.068 Neutral MLH1 P40692 C142D 142 C D 0.6 Pathogenic MLH1 P40692 C142E 142 C E 0.592 Pathogenic MLH1 P40692 C142F 142 C F 0.946 Pathogenic MLH1 P40692 C142G 142 C G 0.512 Pathogenic MLH1 P40692 C142H 142 C H 0.726 Pathogenic MLH1 P40692 C142I 142 C I 0.154 Neutral MLH1 P40692 C142K 142 C K 0.106 Neutral MLH1 P40692 C142L 142 C L 0.104 Neutral MLH1 P40692 C142M 142 C M 0.578 Pathogenic MLH1 P40692 C142N 142 C N 0.37 Neutral MLH1 P40692 C142P 142 C P 0.87 Pathogenic MLH1 P40692 C142Q 142 C Q 0.498 Neutral MLH1 P40692 C142R 142 C R 0.916 Pathogenic MLH1 P40692 C142S 142 C S 0.368 Neutral MLH1 P40692 C142T 142 C T 0.008 Neutral MLH1 P40692 C142V 142 C V 0.064 Neutral MLH1 P40692 C142W 142 C W 0.938 Pathogenic MLH1 P40692 C142Y 142 C Y 0.94 Pathogenic MLH1 P40692 A143C 143 A C 0.536 Pathogenic MLH1 P40692 A143D 143 A D 0.94 Pathogenic MLH1 P40692 A143E 143 A E 0.692 Pathogenic MLH1 P40692 A143F 143 A F 0.986 Pathogenic MLH1 P40692 A143G 143 A G 0.766 Pathogenic MLH1 P40692 A143H 143 A H 0.748 Pathogenic MLH1 P40692 A143I 143 A I 0.964 Pathogenic MLH1 P40692 A143K 143 A K 0.744 Pathogenic MLH1 P40692 A143L 143 A L 0.884 Pathogenic MLH1 P40692 A143M 143 A M 0.894 Pathogenic MLH1 P40692 A143N 143 A N 0.86 Pathogenic MLH1 P40692 A143P 143 A P 0.974 Pathogenic MLH1 P40692 A143Q 143 A Q 0.87 Pathogenic MLH1 P40692 A143R 143 A R 0.966 Pathogenic MLH1 P40692 A143S 143 A S 0.276 Neutral MLH1 P40692 A143T 143 A T 0.832 Pathogenic MLH1 P40692 A143V 143 A V 0.932 Pathogenic MLH1 P40692 A143W 143 A W 0.99 Pathogenic MLH1 P40692 A143Y 143 A Y 0.968 Pathogenic MLH1 P40692 G144A 144 G A 0.336 Neutral MLH1 P40692 G144C 144 G C 0.772 Pathogenic MLH1 P40692 G144D 144 G D 0.97 Pathogenic MLH1 P40692 G144E 144 G E 0.978 Pathogenic MLH1 P40692 G144F 144 G F 0.98 Pathogenic MLH1 P40692 G144H 144 G H 0.984 Pathogenic MLH1 P40692 G144I 144 G I 0.97 Pathogenic MLH1 P40692 G144K 144 G K 0.788 Pathogenic MLH1 P40692 G144L 144 G L 0.98 Pathogenic MLH1 P40692 G144M 144 G M 0.988 Pathogenic MLH1 P40692 G144N 144 G N 0.944 Pathogenic MLH1 P40692 G144P 144 G P 0.974 Pathogenic MLH1 P40692 G144Q 144 G Q 0.984 Pathogenic MLH1 P40692 G144R 144 G R 0.884 Pathogenic MLH1 P40692 G144S 144 G S 0.382 Neutral MLH1 P40692 G144T 144 G T 0.904 Pathogenic MLH1 P40692 G144V 144 G V 0.92 Pathogenic MLH1 P40692 G144W 144 G W 0.976 Pathogenic MLH1 P40692 G144Y 144 G Y 0.842 Pathogenic MLH1 P40692 N145A 145 N A 0.53 Pathogenic MLH1 P40692 N145C 145 N C 0.604 Pathogenic MLH1 P40692 N145D 145 N D 0.552 Pathogenic MLH1 P40692 N145E 145 N E 0.552 Pathogenic MLH1 P40692 N145F 145 N F 0.906 Pathogenic MLH1 P40692 N145G 145 N G 0.622 Pathogenic MLH1 P40692 N145H 145 N H 0.77 Pathogenic MLH1 P40692 N145I 145 N I 0.894 Pathogenic MLH1 P40692 N145K 145 N K 0.078 Neutral MLH1 P40692 N145L 145 N L 0.808 Pathogenic MLH1 P40692 N145M 145 N M 0.86 Pathogenic MLH1 P40692 N145P 145 N P 0.77 Pathogenic MLH1 P40692 N145Q 145 N Q 0.574 Pathogenic MLH1 P40692 N145R 145 N R 0.472 Neutral MLH1 P40692 N145S 145 N S 0.458 Neutral MLH1 P40692 N145T 145 N T 0.026 Neutral MLH1 P40692 N145V 145 N V 0.104 Neutral MLH1 P40692 N145W 145 N W 0.954 Pathogenic MLH1 P40692 N145Y 145 N Y 0.944 Pathogenic MLH1 P40692 Q146A 146 Q A 0.442 Neutral MLH1 P40692 Q146C 146 Q C 0.448 Neutral MLH1 P40692 Q146D 146 Q D 0.07 Neutral MLH1 P40692 Q146E 146 Q E 0.61 Pathogenic MLH1 P40692 Q146F 146 Q F 0.798 Pathogenic MLH1 P40692 Q146G 146 Q G 0.176 Neutral MLH1 P40692 Q146H 146 Q H 0.758 Pathogenic MLH1 P40692 Q146I 146 Q I 0.378 Neutral MLH1 P40692 Q146K 146 Q K 0.09 Neutral MLH1 P40692 Q146L 146 Q L 0.728 Pathogenic MLH1 P40692 Q146M 146 Q M 0.744 Pathogenic MLH1 P40692 Q146N 146 Q N 0.146 Neutral MLH1 P40692 Q146P 146 Q P 0.374 Neutral MLH1 P40692 Q146R 146 Q R 0.114 Neutral MLH1 P40692 Q146S 146 Q S 0.644 Pathogenic MLH1 P40692 Q146T 146 Q T 0.07 Neutral MLH1 P40692 Q146V 146 Q V 0.142 Neutral MLH1 P40692 Q146W 146 Q W 0.914 Pathogenic MLH1 P40692 Q146Y 146 Q Y 0.872 Pathogenic MLH1 P40692 G147A 147 G A 0.96 Pathogenic MLH1 P40692 G147C 147 G C 0.942 Pathogenic MLH1 P40692 G147D 147 G D 0.734 Pathogenic MLH1 P40692 G147E 147 G E 0.68 Pathogenic MLH1 P40692 G147F 147 G F 0.982 Pathogenic MLH1 P40692 G147H 147 G H 0.986 Pathogenic MLH1 P40692 G147I 147 G I 0.974 Pathogenic MLH1 P40692 G147K 147 G K 0.868 Pathogenic MLH1 P40692 G147L 147 G L 0.904 Pathogenic MLH1 P40692 G147M 147 G M 0.994 Pathogenic MLH1 P40692 G147N 147 G N 0.986 Pathogenic MLH1 P40692 G147P 147 G P 0.964 Pathogenic MLH1 P40692 G147Q 147 G Q 0.99 Pathogenic MLH1 P40692 G147R 147 G R 1 Pathogenic MLH1 P40692 G147S 147 G S 0.87 Pathogenic MLH1 P40692 G147T 147 G T 0.85 Pathogenic MLH1 P40692 G147V 147 G V 0.986 Pathogenic MLH1 P40692 G147W 147 G W 0.978 Pathogenic MLH1 P40692 G147Y 147 G Y 0.958 Pathogenic MLH1 P40692 T148A 148 T A 0.294 Neutral MLH1 P40692 T148C 148 T C 0.938 Pathogenic MLH1 P40692 T148D 148 T D 0.948 Pathogenic MLH1 P40692 T148E 148 T E 0.95 Pathogenic MLH1 P40692 T148F 148 T F 0.95 Pathogenic MLH1 P40692 T148G 148 T G 0.74 Pathogenic MLH1 P40692 T148H 148 T H 0.918 Pathogenic MLH1 P40692 T148I 148 T I 0.636 Pathogenic MLH1 P40692 T148K 148 T K 0.94 Pathogenic MLH1 P40692 T148L 148 T L 0.95 Pathogenic MLH1 P40692 T148M 148 T M 0.984 Pathogenic MLH1 P40692 T148N 148 T N 0.386 Neutral MLH1 P40692 T148P 148 T P 0.64 Pathogenic MLH1 P40692 T148Q 148 T Q 0.884 Pathogenic MLH1 P40692 T148R 148 T R 0.994 Pathogenic MLH1 P40692 T148S 148 T S 0.824 Pathogenic MLH1 P40692 T148V 148 T V 0.874 Pathogenic MLH1 P40692 T148W 148 T W 0.982 Pathogenic MLH1 P40692 T148Y 148 T Y 0.88 Pathogenic MLH1 P40692 Q149A 149 Q A 0.538 Pathogenic MLH1 P40692 Q149C 149 Q C 0.492 Neutral MLH1 P40692 Q149D 149 Q D 0.548 Pathogenic MLH1 P40692 Q149E 149 Q E 0.584 Pathogenic MLH1 P40692 Q149F 149 Q F 0.84 Pathogenic MLH1 P40692 Q149G 149 Q G 0.462 Neutral MLH1 P40692 Q149H 149 Q H 0.808 Pathogenic MLH1 P40692 Q149I 149 Q I 0.324 Neutral MLH1 P40692 Q149K 149 Q K 0.788 Pathogenic MLH1 P40692 Q149L 149 Q L 0.192 Neutral MLH1 P40692 Q149M 149 Q M 0.692 Pathogenic MLH1 P40692 Q149N 149 Q N 0.598 Pathogenic MLH1 P40692 Q149P 149 Q P 0.856 Pathogenic MLH1 P40692 Q149R 149 Q R 0.386 Neutral MLH1 P40692 Q149S 149 Q S 0.098 Neutral MLH1 P40692 Q149T 149 Q T 0.018 Neutral MLH1 P40692 Q149V 149 Q V 0.09 Neutral MLH1 P40692 Q149W 149 Q W 0.926 Pathogenic MLH1 P40692 Q149Y 149 Q Y 0.888 Pathogenic MLH1 P40692 V15A 15 V A 0.326 Neutral MLH1 P40692 V15C 15 V C 0.72 Pathogenic MLH1 P40692 V15D 15 V D 0.862 Pathogenic MLH1 P40692 V15E 15 V E 0.976 Pathogenic MLH1 P40692 V15F 15 V F 0.89 Pathogenic MLH1 P40692 V15G 15 V G 0.886 Pathogenic MLH1 P40692 V15H 15 V H 0.834 Pathogenic MLH1 P40692 V15I 15 V I 0.812 Pathogenic MLH1 P40692 V15K 15 V K 0.988 Pathogenic MLH1 P40692 V15L 15 V L 0.248 Neutral MLH1 P40692 V15M 15 V M 0.832 Pathogenic MLH1 P40692 V15N 15 V N 0.92 Pathogenic MLH1 P40692 V15P 15 V P 0.98 Pathogenic MLH1 P40692 V15Q 15 V Q 0.982 Pathogenic MLH1 P40692 V15R 15 V R 0.952 Pathogenic MLH1 P40692 V15S 15 V S 0.724 Pathogenic MLH1 P40692 V15T 15 V T 0.188 Neutral MLH1 P40692 V15W 15 V W 0.918 Pathogenic MLH1 P40692 V15Y 15 V Y 0.946 Pathogenic MLH1 P40692 I150A 150 I A 0.6 Pathogenic MLH1 P40692 I150C 150 I C 0.686 Pathogenic MLH1 P40692 I150D 150 I D 0.758 Pathogenic MLH1 P40692 I150E 150 I E 0.758 Pathogenic MLH1 P40692 I150F 150 I F 0.942 Pathogenic MLH1 P40692 I150G 150 I G 0.822 Pathogenic MLH1 P40692 I150H 150 I H 0.904 Pathogenic MLH1 P40692 I150K 150 I K 0.85 Pathogenic MLH1 P40692 I150L 150 I L 0.122 Neutral MLH1 P40692 I150M 150 I M 0.706 Pathogenic MLH1 P40692 I150N 150 I N 0.78 Pathogenic MLH1 P40692 I150P 150 I P 0.932 Pathogenic MLH1 P40692 I150Q 150 I Q 0.79 Pathogenic MLH1 P40692 I150R 150 I R 0.864 Pathogenic MLH1 P40692 I150S 150 I S 0.36 Neutral MLH1 P40692 I150T 150 I T 0.226 Neutral MLH1 P40692 I150V 150 I V 0.128 Neutral MLH1 P40692 I150W 150 I W 0.982 Pathogenic MLH1 P40692 I150Y 150 I Y 0.968 Pathogenic MLH1 P40692 T151A 151 T A 0.128 Neutral MLH1 P40692 T151C 151 T C 0.354 Neutral MLH1 P40692 T151D 151 T D 0.388 Neutral MLH1 P40692 T151E 151 T E 0.638 Pathogenic MLH1 P40692 T151F 151 T F 0.754 Pathogenic MLH1 P40692 T151G 151 T G 0.132 Neutral MLH1 P40692 T151H 151 T H 0.466 Neutral MLH1 P40692 T151I 151 T I 0.14 Neutral MLH1 P40692 T151K 151 T K 0.292 Neutral MLH1 P40692 T151L 151 T L 0.066 Neutral MLH1 P40692 T151M 151 T M 0.156 Neutral MLH1 P40692 T151N 151 T N 0.158 Neutral MLH1 P40692 T151P 151 T P 0.644 Pathogenic MLH1 P40692 T151Q 151 T Q 0.098 Neutral MLH1 P40692 T151R 151 T R 0.588 Pathogenic MLH1 P40692 T151S 151 T S 0.01 Neutral MLH1 P40692 T151V 151 T V 0.054 Neutral MLH1 P40692 T151W 151 T W 0.948 Pathogenic MLH1 P40692 T151Y 151 T Y 0.944 Pathogenic MLH1 P40692 V152A 152 V A 0.06 Neutral MLH1 P40692 V152C 152 V C 0.71 Pathogenic MLH1 P40692 V152D 152 V D 0.172 Neutral MLH1 P40692 V152E 152 V E 0.978 Pathogenic MLH1 P40692 V152F 152 V F 0.872 Pathogenic MLH1 P40692 V152G 152 V G 0.906 Pathogenic MLH1 P40692 V152H 152 V H 0.812 Pathogenic MLH1 P40692 V152I 152 V I 0.16 Neutral MLH1 P40692 V152K 152 V K 0.976 Pathogenic MLH1 P40692 V152L 152 V L 0.472 Neutral MLH1 P40692 V152M 152 V M 0.81 Pathogenic MLH1 P40692 V152N 152 V N 0.932 Pathogenic MLH1 P40692 V152P 152 V P 0.976 Pathogenic MLH1 P40692 V152Q 152 V Q 0.99 Pathogenic MLH1 P40692 V152R 152 V R 0.958 Pathogenic MLH1 P40692 V152S 152 V S 0.744 Pathogenic MLH1 P40692 V152T 152 V T 0.292 Neutral MLH1 P40692 V152W 152 V W 0.672 Pathogenic MLH1 P40692 V152Y 152 V Y 0.928 Pathogenic MLH1 P40692 E153A 153 E A 0.42 Neutral MLH1 P40692 E153C 153 E C 0.702 Pathogenic MLH1 P40692 E153D 153 E D 0.208 Neutral MLH1 P40692 E153F 153 E F 0.97 Pathogenic MLH1 P40692 E153G 153 E G 0.378 Neutral MLH1 P40692 E153H 153 E H 0.702 Pathogenic MLH1 P40692 E153I 153 E I 0.98 Pathogenic MLH1 P40692 E153K 153 E K 0.982 Pathogenic MLH1 P40692 E153L 153 E L 0.98 Pathogenic MLH1 P40692 E153M 153 E M 0.924 Pathogenic MLH1 P40692 E153N 153 E N 0.696 Pathogenic MLH1 P40692 E153P 153 E P 0.934 Pathogenic MLH1 P40692 E153Q 153 E Q 0.186 Neutral MLH1 P40692 E153R 153 E R 0.462 Neutral MLH1 P40692 E153S 153 E S 0.342 Neutral MLH1 P40692 E153T 153 E T 0.882 Pathogenic MLH1 P40692 E153V 153 E V 0.666 Pathogenic MLH1 P40692 E153W 153 E W 0.986 Pathogenic MLH1 P40692 E153Y 153 E Y 0.966 Pathogenic MLH1 P40692 D154A 154 D A 0.67 Pathogenic MLH1 P40692 D154C 154 D C 0.906 Pathogenic MLH1 P40692 D154E 154 D E 0.27 Neutral MLH1 P40692 D154F 154 D F 0.982 Pathogenic MLH1 P40692 D154G 154 D G 0.376 Neutral MLH1 P40692 D154H 154 D H 0.61 Pathogenic MLH1 P40692 D154I 154 D I 0.8 Pathogenic MLH1 P40692 D154K 154 D K 0.97 Pathogenic MLH1 P40692 D154L 154 D L 0.982 Pathogenic MLH1 P40692 D154M 154 D M 0.942 Pathogenic MLH1 P40692 D154N 154 D N 0.068 Neutral MLH1 P40692 D154P 154 D P 0.91 Pathogenic MLH1 P40692 D154Q 154 D Q 0.436 Neutral MLH1 P40692 D154R 154 D R 0.892 Pathogenic MLH1 P40692 D154S 154 D S 0.708 Pathogenic MLH1 P40692 D154T 154 D T 0.292 Neutral MLH1 P40692 D154V 154 D V 0.996 Pathogenic MLH1 P40692 D154W 154 D W 0.986 Pathogenic MLH1 P40692 D154Y 154 D Y 0.98 Pathogenic MLH1 P40692 L155A 155 L A 0.208 Neutral MLH1 P40692 L155C 155 L C 0.686 Pathogenic MLH1 P40692 L155D 155 L D 0.534 Pathogenic MLH1 P40692 L155E 155 L E 0.862 Pathogenic MLH1 P40692 L155F 155 L F 0.794 Pathogenic MLH1 P40692 L155G 155 L G 0.784 Pathogenic MLH1 P40692 L155H 155 L H 0.816 Pathogenic MLH1 P40692 L155I 155 L I 0.324 Neutral MLH1 P40692 L155K 155 L K 0.734 Pathogenic MLH1 P40692 L155M 155 L M 0.202 Neutral MLH1 P40692 L155N 155 L N 0.742 Pathogenic MLH1 P40692 L155P 155 L P 0.978 Pathogenic MLH1 P40692 L155Q 155 L Q 0.614 Pathogenic MLH1 P40692 L155R 155 L R 0.986 Pathogenic 5 MLH1 P40692 L155S 155 L S 0.59 Pathogenic MLH1 P40692 L155T 155 L T 0.572 Pathogenic MLH1 P40692 L155V 155 L V 0.538 Pathogenic MLH1 P40692 L155W 155 L W 0.94 Pathogenic MLH1 P40692 L155Y 155 L Y 0.904 Pathogenic MLH1 P40692 F156A 156 F A 0.464 Neutral MLH1 P40692 F156C 156 F C 0.652 Pathogenic MLH1 P40692 F156D 156 F D 0.778 Pathogenic MLH1 P40692 F156E 156 F E 0.84 Pathogenic MLH1 P40692 F156G 156 F G 0.472 Neutral MLH1 P40692 F156H 156 F H 0.704 Pathogenic MLH1 P40692 F156I 156 F I 0.616 Pathogenic MLH1 P40692 F156K 156 F K 0.824 Pathogenic MLH1 P40692 F156L 156 F L 0.12 Neutral MLH1 P40692 F156M 156 F M 0.726 Pathogenic MLH1 P40692 F156N 156 F N 0.694 Pathogenic MLH1 P40692 F156P 156 F P 0.95 Pathogenic MLH1 P40692 F156Q 156 F Q 0.712 Pathogenic MLH1 P40692 F156R 156 F R 0.906 Pathogenic MLH1 P40692 F156S 156 F S 0.8 Pathogenic MLH1 P40692 F156T 156 F T 0.598 Pathogenic MLH1 P40692 F156V 156 F V 0.86 Pathogenic MLH1 P40692 F156W 156 F W 0.832 Pathogenic MLH1 P40692 F156Y 156 F Y 0.414 Neutral MLH1 P40692 Y157A 157 Y A 0.326 Neutral MLH1 P40692 Y157C 157 Y C 0.536 Pathogenic MLH1 P40692 Y157D 157 Y D 0.782 Pathogenic MLH1 P40692 Y157E 157 Y E 0.42 Neutral MLH1 P40692 Y157F 157 Y F 0.066 Neutral MLH1 P40692 Y157G 157 Y G 0.234 Neutral MLH1 P40692 Y157H 157 Y H 0.09 Neutral MLH1 P40692 Y157I 157 Y I 0.676 Pathogenic MLH1 P40692 Y157K 157 Y K 0.414 Neutral MLH1 P40692 Y157L 157 Y L 0.56 Pathogenic MLH1 P40692 Y157M 157 Y M 0.574 Pathogenic MLH1 P40692 Y157N 157 Y N 0.608 Pathogenic MLH1 P40692 Y157P 157 Y P 0.696 Pathogenic MLH1 P40692 Y157Q 157 Y Q 0.518 Pathogenic MLH1 P40692 Y157R 157 Y R 0.732 Pathogenic MLH1 P40692 Y157S 157 Y S 0.372 Neutral MLH1 P40692 Y157T 157 Y T 0.53 Pathogenic MLH1 P40692 Y157V 157 Y V 0.732 Pathogenic MLH1 P40692 Y157W 157 Y W 0.794 Pathogenic MLH1 P40692 N158A 158 N A 0.736 Pathogenic MLH1 P40692 N158C 158 N C 0.802 Pathogenic MLH1 P40692 N158D 158 N D 0.854 Pathogenic MLH1 P40692 N158E 158 N E 0.74 Pathogenic MLH1 P40692 N158F 158 N F 0.966 Pathogenic MLH1 P40692 N158G 158 N G 0.402 Neutral MLH1 P40692 N158H 158 N H 0.948 Pathogenic MLH1 P40692 N158I 158 N I 0.948 Pathogenic MLH1 P40692 N158K 158 N K 0.986 Pathogenic MLH1 P40692 N158L 158 N L 0.966 Pathogenic MLH1 P40692 N158M 158 N M 0.972 Pathogenic MLH1 P40692 N158P 158 N P 0.896 Pathogenic MLH1 P40692 N158Q 158 N Q 0.966 Pathogenic MLH1 P40692 N158R 158 N R 0.924 Pathogenic MLH1 P40692 N158S 158 N S 0.406 Neutral MLH1 P40692 N158T 158 N T 0.258 Neutral MLH1 P40692 N158V 158 N V 0.99 Pathogenic MLH1 P40692 N158W 158 N W 0.978 Pathogenic MLH1 P40692 N158Y 158 N Y 0.802 Pathogenic MLH1 P40692 I159A 159 I A 0.164 Neutral MLH1 P40692 I159C 159 I C 0.378 Neutral MLH1 P40692 I159D 159 I D 0.574 Pathogenic MLH1 P40692 I159E 159 I E 0.558 Pathogenic MLH1 P40692 I159F 159 I F 0.69 Pathogenic MLH1 P40692 I159G 159 I G 0.552 Pathogenic MLH1 P40692 I159H 159 I H 0.434 Neutral MLH1 P40692 I159K 159 I K 0.574 Pathogenic MLH1 P40692 I159L 159 I L 0.014 Neutral MLH1 P40692 I159M 159 I M 0.04 Neutral MLH1 P40692 I159N 159 I N 0.148 Neutral MLH1 P40692 I159P 159 I P 0.708 Pathogenic MLH1 P40692 I159Q 159 I Q 0.594 Pathogenic MLH1 P40692 I159R 159 I R 0.784 Pathogenic MLH1 P40692 I159S 159 I S 0.512 Pathogenic MLH1 P40692 I159T 159 I T 0.028 Neutral MLH1 P40692 I159V 159 I V 0.152 Neutral MLH1 P40692 I159W 159 I W 0.9 Pathogenic MLH1 P40692 I159Y 159 I Y 0.906 Pathogenic MLH1 P40692 V16A 16 V A 0.35 Neutral MLH1 P40692 V16C 16 V C 0.718 Pathogenic MLH1 P40692 V16D 16 V D 0.868 Pathogenic MLH1 P40692 V16E 16 V E 0.98 Pathogenic MLH1 P40692 V16F 16 V F 0.872 Pathogenic MLH1 P40692 V16G 16 V G 0.908 Pathogenic MLH1 P40692 V16H 16 V H 0.816 Pathogenic MLH1 P40692 V16I 16 V I 0.156 Neutral MLH1 P40692 V16K 16 V K 0.978 Pathogenic MLH1 P40692 V16L 16 V L 0.83 Pathogenic MLH1 P40692 V16M 16 V M 0.814 Pathogenic MLH1 P40692 V16N 16 V N 0.934 Pathogenic MLH1 P40692 V16P 16 V P 0.976 Pathogenic MLH1 P40692 V16Q 16 V Q 0.99 Pathogenic MLH1 P40692 V16R 16 V R 0.958 Pathogenic MLH1 P40692 V16S 16 V S 0.748 Pathogenic MLH1 P40692 V16T 16 V T 0.162 Neutral MLH1 P40692 V16W 16 V W 0.902 Pathogenic MLH1 P40692 V16Y 16 V Y 0.928 Pathogenic MLH1 P40692 A160C 160 A C 0.71 Pathogenic MLH1 P40692 A160D 160 A D 0.796 Pathogenic MLH1 P40692 A160E 160 A E 0.854 Pathogenic MLH1 P40692 A160F 160 A F 0.928 Pathogenic MLH1 P40692 A160G 160 A G 0.102 Neutral MLH1 P40692 A160H 160 A H 0.868 Pathogenic MLH1 P40692 A160I 160 A I 0.692 Pathogenic MLH1 P40692 A160K 160 A K 0.91 Pathogenic MLH1 P40692 A160L 160 A L 0.932 Pathogenic MLH1 P40692 A160M 160 A M 0.612 Pathogenic MLH1 P40692 A160N 160 A N 0.584 Pathogenic MLH1 P40692 A160P 160 A P 0.296 Neutral MLH1 P40692 A160Q 160 A Q 0.79 Pathogenic MLH1 P40692 A160R 160 A R 0.926 Pathogenic MLH1 P40692 A160S 160 A S 0.022 Neutral MLH1 P40692 A160T 160 A T 0.06 Neutral MLH1 P40692 A160V 160 A V 0.158 Neutral MLH1 P40692 A160W 160 A W 0.948 Pathogenic MLH1 P40692 A160Y 160 A Y 0.934 Pathogenic MLH1 P40692 T161A 161 T A 0.044 Neutral MLH1 P40692 T161C 161 T C 0.54 Pathogenic MLH1 P40692 T161D 161 T D 0.56 Pathogenic MLH1 P40692 T161E 161 T E 0.664 Pathogenic MLH1 P40692 T161F 161 T F 0.76 Pathogenic MLH1 P40692 T161G 161 T G 0.308 Neutral MLH1 P40692 T161H 161 T H 0.606 Pathogenic MLH1 P40692 T161I 161 T I 0.152 Neutral MLH1 P40692 T161K 161 T K 0.574 Pathogenic MLH1 P40692 T161L 161 T L 0.086 Neutral MLH1 P40692 T161M 161 T M 0.17 Neutral MLH1 P40692 T161N 161 T N 0.164 Neutral MLH1 P40692 T161P 161 T P 0.672 Pathogenic MLH1 P40692 T161Q 161 T Q 0.03 Neutral MLH1 P40692 T161R 161 T R 0.848 Pathogenic MLH1 P40692 T161S 161 T S 0.01 Neutral MLH1 P40692 T161V 161 T V 0.056 Neutral MLH1 P40692 T161W 161 T W 0.95 Pathogenic MLH1 P40692 T161Y 161 T Y 0.946 Pathogenic MLH1 P40692 R162A 162 R A 0.56 Pathogenic MLH1 P40692 R162C 162 R C 0.96 Pathogenic MLH1 P40692 R162D 162 R D 0.872 Pathogenic MLH1 P40692 R162E 162 R E 0.864 Pathogenic MLH1 P40692 R162F 162 R F 0.974 Pathogenic MLH1 P40692 R162G 162 R G 0.426 Neutral MLH1 P40692 R162H 162 R H 0.568 Pathogenic MLH1 P40692 R162I 162 R I 0.72 Pathogenic MLH1 P40692 R162K 162 R K 0.606 Pathogenic MLH1 P40692 R162L 162 R L 0.686 Pathogenic MLH1 P40692 R162M 162 R M 0.806 Pathogenic MLH1 P40692 R162N 162 R N 0.77 Pathogenic MLH1 P40692 R162P 162 R P 0.99 Pathogenic MLH1 P40692 R162Q 162 R Q 0.632 Pathogenic MLH1 P40692 R162S 162 R S 0.914 Pathogenic MLH1 P40692 R162T 162 R T 0.18 Neutral MLH1 P40692 R162V 162 R V 0.976 Pathogenic MLH1 P40692 R162W 162 R W 0.97 Pathogenic MLH1 P40692 R162Y 162 R Y 0.976 Pathogenic MLH1 P40692 R163A 163 R A 0.384 Neutral MLH1 P40692 R163C 163 R C 0.62 Pathogenic MLH1 P40692 R163D 163 R D 0.61 Pathogenic MLH1 P40692 R163E 163 R E 0.558 Pathogenic MLH1 P40692 R163F 163 R F 0.85 Pathogenic MLH1 P40692 R163G 163 R G 0.22 Neutral MLH1 P40692 R163H 163 R H 0.476 Neutral MLH1 P40692 R163I 163 R I 0.87 Pathogenic MLH1 P40692 R163K 163 R K 0.026 Neutral MLH1 P40692 R163L 163 R L 0.206 Neutral MLH1 P40692 R163M 163 R M 0.618 Pathogenic MLH1 P40692 R163N 163 R N 0.53 Pathogenic MLH1 P40692 R163P 163 R P 0.786 Pathogenic MLH1 P40692 R163Q 163 R Q 0.64 Pathogenic MLH1 P40692 R163S 163 R S 0.464 Neutral MLH1 P40692 R163T 163 R T 0.518 Pathogenic MLH1 P40692 R163V 163 R V 0.78 Pathogenic MLH1 P40692 R163W 163 R W 0.854 Pathogenic MLH1 P40692 R163Y 163 R Y 0.812 Pathogenic MLH1 P40692 K164A 164 K A 0.234 Neutral MLH1 P40692 K164C 164 K C 0.19 Neutral MLH1 P40692 K164D 164 K D 0.292 Neutral MLH1 P40692 K164E 164 K E 0.338 Neutral MLH1 P40692 K164F 164 K F 0.79 Pathogenic MLH1 P40692 K164G 164 K G 0.356 Neutral MLH1 P40692 K164H 164 K H 0.074 Neutral MLH1 P40692 K164I 164 K I 0.892 Pathogenic MLH1 P40692 K164L 164 K L 0.094 Neutral MLH1 P40692 K164M 164 K M 0.586 Pathogenic MLH1 P40692 K164N 164 K N 0.026 Neutral MLH1 P40692 K164P 164 K P 0.832 Pathogenic MLH1 P40692 K164Q 164 K Q 0.03 Neutral MLH1 P40692 K164R 164 K R 0.03 Neutral MLH1 P40692 K164S 164 K S 0.444 Neutral MLH1 P40692 K164T 164 K T 0.286 Neutral MLH1 P40692 K164V 164 K V 0.786 Pathogenic MLH1 P40692 K164W 164 K W 0.978 Pathogenic MLH1 P40692 K164Y 164 K Y 0.932 Pathogenic MLH1 P40692 A165C 165 A C 0.68 Pathogenic MLH1 P40692 A165D 165 A D 0.906 Pathogenic MLH1 P40692 A165E 165 A E 0.882 Pathogenic MLH1 P40692 A165F 165 A F 0.968 Pathogenic MLH1 P40692 A165G 165 A G 0.48 Neutral MLH1 P40692 A165H 165 A H 0.87 Pathogenic MLH1 P40692 A165I 165 A I 0.942 Pathogenic MLH1 P40692 A165K 165 A K 0.55 Pathogenic MLH1 P40692 A165L 165 A L 0.922 Pathogenic MLH1 P40692 A165M 165 A M 0.82 Pathogenic MLH1 P40692 A165N 165 A N 0.576 Pathogenic MLH1 P40692 A165P 165 A P 0.886 Pathogenic MLH1 P40692 A165Q 165 A Q 0.522 Pathogenic MLH1 P40692 A165R 165 A R 0.622 Pathogenic MLH1 P40692 A165S 165 A S 0.016 Neutral MLH1 P40692 A165T 165 A T 0.066 Neutral MLH1 P40692 A165V 165 A V 0.756 Pathogenic MLH1 P40692 A165W 165 A W 0.954 Pathogenic MLH1 P40692 A165Y 165 A Y 0.94 Pathogenic MLH1 P40692 L166A 166 L A 0.562 Pathogenic MLH1 P40692 L166C 166 L C 0.686 Pathogenic MLH1 P40692 L166D 166 L D 0.916 Pathogenic MLH1 P40692 L166E 166 L E 0.896 Pathogenic MLH1 P40692 L166F 166 L F 0.464 Neutral MLH1 P40692 L166G 166 L G 0.814 Pathogenic MLH1 P40692 L166H 166 L H 0.34 Neutral MLH1 P40692 L166I 166 L I 0.416 Neutral MLH1 P40692 L166K 166 L K 0.734 Pathogenic MLH1 P40692 L166M 166 L M 0.198 Neutral MLH1 P40692 L166N 166 L N 0.484 Neutral MLH1 P40692 L166P 166 L P 0.682 Pathogenic MLH1 P40692 L166Q 166 L Q 0.308 Neutral MLH1 P40692 L166R 166 L R 0.998 Pathogenic MLH1 P40692 L166S 166 L S 0.608 Pathogenic MLH1 P40692 L166T 166 L T 0.332 Neutral MLH1 P40692 L166V 166 L V 0.556 Pathogenic MLH1 P40692 L166W 166 L W 0.81 Pathogenic MLH1 P40692 L166Y 166 L Y 0.87 Pathogenic MLH1 P40692 K167A 167 K A 0.268 Neutral MLH1 P40692 K167C 167 K C 0.218 Neutral MLH1 P40692 K167D 167 K D 0.342 Neutral MLH1 P40692 K167E 167 K E 0.398 Neutral MLH1 P40692 K167F 167 K F 0.832 Pathogenic MLH1 P40692 K167G 167 K G 0.364 Neutral MLH1 P40692 K167H 167 K H 0.422 Neutral MLH1 P40692 K167I 167 K I 0.89 Pathogenic MLH1 P40692 K167L 167 K L 0.668 Pathogenic MLH1 P40692 K167M 167 K M 0.634 Pathogenic MLH1 P40692 K167N 167 K N 0.028 Neutral MLH1 P40692 K167P 167 K P 0.808 Pathogenic MLH1 P40692 K167Q 167 K Q 0.028 Neutral MLH1 P40692 K167R 167 K R 0.034 Neutral MLH1 P40692 K167S 167 K S 0.028 Neutral MLH1 P40692 K167T 167 K T 0.256 Neutral MLH1 P40692 K167V 167 K V 0.602 Pathogenic MLH1 P40692 K167W 167 K W 0.96 Pathogenic MLH1 P40692 K167Y 167 K Y 0.914 Pathogenic MLH1 P40692 N168A 168 N A 0.35 Neutral MLH1 P40692 N168C 168 N C 0.584 Pathogenic MLH1 P40692 N168D 168 N D 0.6 Pathogenic MLH1 P40692 N168E 168 N E 0.5 Pathogenic MLH1 P40692 N168F 168 N F 0.912 Pathogenic MLH1 P40692 N168G 168 N G 0.214 Neutral MLH1 P40692 N168H 168 N H 0.77 Pathogenic MLH1 P40692 N168I 168 N I 0.896 Pathogenic MLH1 P40692 N168K 168 N K 0.824 Pathogenic MLH1 P40692 N168L 168 N L 0.888 Pathogenic MLH1 P40692 N168M 168 N M 0.87 Pathogenic MLH1 P40692 N168P 168 N P 0.748 Pathogenic MLH1 P40692 N168Q 168 N Q 0.72 Pathogenic MLH1 P40692 N168R 168 N R 0.83 Pathogenic MLH1 P40692 N168S 168 N S 0.436 Neutral MLH1 P40692 N168T 168 N T 0.228 Neutral MLH1 P40692 N168V 168 N V 0.93 Pathogenic MLH1 P40692 N168W 168 N W 0.922 Pathogenic MLH1 P40692 N168Y 168 N Y 0.918 Pathogenic MLH1 P40692 P169A 169 P A 0.074 Neutral MLH1 P40692 P169C 169 P C 0.584 Pathogenic MLH1 P40692 P169D 169 P D 0.406 Neutral MLH1 P40692 P169E 169 P E 0.708 Pathogenic MLH1 P40692 P169F 169 P F 0.626 Pathogenic MLH1 P40692 P169G 169 P G 0.08 Neutral MLH1 P40692 P169H 169 P H 0.568 Pathogenic MLH1 P40692 P169I 169 P I 0.422 Neutral MLH1 P40692 P169K 169 P K 0.138 Neutral MLH1 P40692 P169L 169 P L 0.642 Pathogenic MLH1 P40692 P169M 169 P M 0.722 Pathogenic MLH1 P40692 P169N 169 P N 0.228 Neutral MLH1 P40692 P169Q 169 P Q 0.56 Pathogenic MLH1 P40692 P169R 169 P R 0.87 Pathogenic MLH1 P40692 P169S 169 P S 0.034 Neutral MLH1 P40692 P169T 169 P T 0.05 Neutral MLH1 P40692 P169V 169 P V 0.574 Pathogenic MLH1 P40692 P169W 169 P W 0.924 Pathogenic MLH1 P40692 P169Y 169 P Y 0.75 Pathogenic MLH1 P40692 N17A 17 N A 0.42 Neutral MLH1 P40692 N17C 17 N C 0.762 Pathogenic MLH1 P40692 N17D 17 N D 0.314 Neutral MLH1 P40692 N17E 17 N E 0.708 Pathogenic MLH1 P40692 N17F 17 N F 0.962 Pathogenic MLH1 P40692 N17G 17 N G 0.408 Neutral MLH1 P40692 N17H 17 N H 0.93 Pathogenic MLH1 P40692 N17I 17 N I 0.93 Pathogenic MLH1 P40692 N17K 17 N K 0.968 Pathogenic MLH1 P40692 N17L 17 N L 0.948 Pathogenic MLH1 P40692 N17M 17 N M 0.956 Pathogenic MLH1 P40692 N17P 17 N P 0.868 Pathogenic MLH1 P40692 N17Q 17 N Q 0.938 Pathogenic MLH1 P40692 N17R 17 N R 0.904 Pathogenic MLH1 P40692 N17S 17 N S 0.41 Neutral MLH1 P40692 N17T 17 N T 0.652 Pathogenic MLH1 P40692 N17V 17 N V 0.97 Pathogenic MLH1 P40692 N17W 17 N W 0.972 Pathogenic MLH1 P40692 N17Y 17 N Y 0.968 Pathogenic MLH1 P40692 S170A 170 S A 0.04 Neutral MLH1 P40692 S170C 170 S C 0.35 Neutral MLH1 P40692 S170D 170 S D 0.572 Pathogenic MLH1 P40692 S170E 170 S E 0.764 Pathogenic MLH1 P40692 S170F 170 S F 0.894 Pathogenic MLH1 P40692 S170G 170 S G 0.032 Neutral MLH1 P40692 S170H 170 S H 0.822 Pathogenic MLH1 P40692 S170I 170 S I 0.65 Pathogenic MLH1 P40692 S170K 170 S K 0.768 Pathogenic MLH1 P40692 S170L 170 S L 0.668 Pathogenic MLH1 P40692 S170M 170 S M 0.976 Pathogenic MLH1 P40692 S170N 170 S N 0.054 Neutral MLH1 P40692 S170P 170 S P 0.684 Pathogenic MLH1 P40692 S170Q 170 S Q 0.716 Pathogenic MLH1 P40692 S170R 170 S R 0.678 Pathogenic MLH1 P40692 S170T 170 S T 0.062 Neutral MLH1 P40692 S170V 170 S V 0.404 Neutral MLH1 P40692 S170W 170 S W 0.942 Pathogenic MLH1 P40692 S170Y 170 S Y 0.926 Pathogenic MLH1 P40692 E171A 171 E A 0.708 Pathogenic MLH1 P40692 E171C 171 E C 0.648 Pathogenic MLH1 P40692 E171D 171 E D 0.076 Neutral MLH1 P40692 E171F 171 E F 0.956 Pathogenic MLH1 P40692 E171G 171 E G 0.376 Neutral MLH1 P40692 E171H 171 E H 0.838 Pathogenic MLH1 P40692 E171I 171 E I 0.574 Pathogenic MLH1 P40692 E171K 171 E K 0.958 Pathogenic MLH1 P40692 E171L 171 E L 0.742 Pathogenic MLH1 P40692 E171M 171 E M 0.684 Pathogenic MLH1 P40692 E171N 171 E N 0.214 Neutral MLH1 P40692 E171P 171 E P 0.93 Pathogenic MLH1 P40692 E171Q 171 E Q 0.706 Pathogenic MLH1 P40692 E171R 171 E R 0.832 Pathogenic MLH1 P40692 E171S 171 E S 0.344 Neutral MLH1 P40692 E171T 171 E T 0.854 Pathogenic MLH1 P40692 E171V 171 E V 0.916 Pathogenic MLH1 P40692 E171W 171 E W 0.986 Pathogenic MLH1 P40692 E171Y 171 E Y 0.966 Pathogenic MLH1 P40692 E172A 172 E A 0.746 Pathogenic MLH1 P40692 E172C 172 E C 0.682 Pathogenic MLH1 P40692 E172D 172 E D 0.166 Neutral MLH1 P40692 E172F 172 E F 0.948 Pathogenic MLH1 P40692 E172G 172 E G 0.368 Neutral MLH1 P40692 E172H 172 E H 0.836 Pathogenic MLH1 P40692 E172I 172 E I 0.96 Pathogenic MLH1 P40692 E172K 172 E K 0.942 Pathogenic MLH1 P40692 E172L 172 E L 0.414 Neutral MLH1 P40692 E172M 172 E M 0.892 Pathogenic MLH1 P40692 E172N 172 E N 0.252 Neutral MLH1 P40692 E172P 172 E P 0.916 Pathogenic MLH1 P40692 E172Q 172 E Q 0.14 Neutral MLH1 P40692 E172R 172 E R 0.552 Pathogenic MLH1 P40692 E172S 172 E S 0.344 Neutral MLH1 P40692 E172T 172 E T 0.85 Pathogenic MLH1 P40692 E172V 172 E V 0.902 Pathogenic MLH1 P40692 E172W 172 E W 0.978 Pathogenic MLH1 P40692 E172Y 172 E Y 0.958 Pathogenic MLH1 P40692 Y173A 173 Y A 0.332 Neutral MLH1 P40692 Y173C 173 Y C 0.512 Pathogenic MLH1 P40692 Y173D 173 Y D 0.788 Pathogenic MLH1 P40692 Y173E 173 Y E 0.744 Pathogenic MLH1 P40692 Y173F 173 Y F 0.078 Neutral MLH1 P40692 Y173G 173 Y G 0.37 Neutral MLH1 P40692 Y173H 173 Y H 0.106 Neutral MLH1 P40692 Y173I 173 Y I 0.258 Neutral MLH1 P40692 Y173K 173 Y K 0.816 Pathogenic MLH1 P40692 Y173L 173 Y L 0.134 Neutral MLH1 P40692 Y173M 173 Y M 0.206 Neutral MLH1 P40692 Y173N 173 Y N 0.584 Pathogenic MLH1 P40692 Y173P 173 Y P 0.63 Pathogenic MLH1 P40692 Y173Q 173 Y Q 0.522 Pathogenic MLH1 P40692 Y173R 173 Y R 0.5 Pathogenic MLH1 P40692 Y173S 173 Y S 0.372 Neutral MLH1 P40692 Y173T 173 Y T 0.514 Pathogenic MLH1 P40692 Y173V 173 Y V 0.388 Neutral MLH1 P40692 Y173W 173 Y W 0.344 Neutral MLH1 P40692 G174A 174 G A 0.054 Neutral MLH1 P40692 G174C 174 G C 0.646 Pathogenic MLH1 P40692 G174D 174 G D 0.684 Pathogenic MLH1 P40692 G174E 174 G E 0.852 Pathogenic MLH1 P40692 G174F 174 G F 0.638 Pathogenic MLH1 P40692 G174H 174 G H 0.588 Pathogenic MLH1 P40692 G174I 174 G I 0.89 Pathogenic MLH1 P40692 G174K 174 G K 0.7 Pathogenic MLH1 P40692 G174L 174 G L 0.904 Pathogenic MLH1 P40692 G174M 174 G M 0.884 Pathogenic MLH1 P40692 G174N 174 G N 0.406 Neutral MLH1 P40692 G174P 174 G P 0.614 Pathogenic MLH1 P40692 G174Q 174 G Q 0.464 Neutral MLH1 P40692 G174R 174 G R 0.58 Pathogenic MLH1 P40692 G174S 174 G S 0.074 Neutral MLH1 P40692 G174T 174 G T 0.512 Pathogenic MLH1 P40692 G174V 174 G V 0.892 Pathogenic MLH1 P40692 G174W 174 G W 0.92 Pathogenic MLH1 P40692 G174Y 174 G Y 0.912 Pathogenic MLH1 P40692 K175A 175 K A 0.542 Pathogenic MLH1 P40692 K175C 175 K C 0.446 Neutral MLH1 P40692 K175D 175 K D 0.618 Pathogenic MLH1 P40692 K175E 175 K E 0.264 Neutral MLH1 P40692 K175F 175 K F 0.954 Pathogenic MLH1 P40692 K175G 175 K G 0.54 Pathogenic MLH1 P40692 K175H 175 K H 0.25 Neutral MLH1 P40692 K175I 175 K I 0.36 Neutral MLH1 P40692 K175L 175 K L 0.684 Pathogenic MLH1 P40692 K175M 175 K M 0.908 Pathogenic MLH1 P40692 K175N 175 K N 0.67 Pathogenic MLH1 P40692 K175P 175 K P 0.916 Pathogenic MLH1 P40692 K175Q 175 K Q 0.734 Pathogenic MLH1 P40692 K175R 175 K R 0.118 Neutral MLH1 P40692 K175S 175 K S 0.704 Pathogenic MLH1 P40692 K175T 175 K T 0.296 Neutral MLH1 P40692 K175V 175 K V 0.87 Pathogenic MLH1 P40692 K175W 175 K W 0.992 Pathogenic MLH1 P40692 K175Y 175 K Y 0.982 Pathogenic MLH1 P40692 I176A 176 I A 0.102 Neutral MLH1 P40692 I176C 176 I C 0.606 Pathogenic MLH1 P40692 I176D 176 I D 0.48 Neutral MLH1 P40692 I176E 176 I E 0.76 Pathogenic MLH1 P40692 I176F 176 I F 0.962 Pathogenic MLH1 P40692 I176G 176 I G 0.802 Pathogenic MLH1 P40692 I176H 176 I H 0.838 Pathogenic MLH1 P40692 I176K 176 I K 0.848 Pathogenic MLH1 P40692 I176L 176 I L 0.114 Neutral MLH1 P40692 I176M 176 I M 0.682 Pathogenic MLH1 P40692 I176N 176 I N 0.202 Neutral MLH1 P40692 I176P 176 I P 0.94 Pathogenic MLH1 P40692 I176Q 176 I Q 0.792 Pathogenic MLH1 P40692 I176R 176 I R 0.876 Pathogenic MLH1 P40692 I176S 176 I S 0.622 Pathogenic MLH1 P40692 I176T 176 I T 0.344 Neutral MLH1 P40692 I176V 176 I V 0.124 Neutral MLH1 P40692 I176W 176 I W 0.986 Pathogenic MLH1 P40692 I176Y 176 I Y 0.978 Pathogenic MLH1 P40692 L177A 177 L A 0.038 Neutral MLH1 P40692 L177C 177 L C 0.176 Neutral MLH1 P40692 L177D 177 L D 0.54 Pathogenic MLH1 P40692 L177E 177 L E 0.562 Pathogenic MLH1 P40692 L177F 177 L F 0.792 Pathogenic MLH1 P40692 L177G 177 L G 0.534 Pathogenic MLH1 P40692 L177H 177 L H 0.046 Neutral MLH1 P40692 L177I 177 L I 0.038 Neutral MLH1 P40692 L177K 177 L K 0.46 Neutral MLH1 P40692 L177M 177 L M 0.454 Neutral MLH1 P40692 L177N 177 L N 0.516 Pathogenic MLH1 P40692 L177P 177 L P 0.908 Pathogenic MLH1 P40692 L177Q 177 L Q 0.3 Neutral MLH1 P40692 L177R 177 L R 0.856 Pathogenic MLH1 P40692 L177S 177 L S 0.044 Neutral MLH1 P40692 L177T 177 L T 0.05 Neutral MLH1 P40692 L177V 177 L V 0.008 Neutral MLH1 P40692 L177W 177 L W 0.868 Pathogenic MLH1 P40692 L177Y 177 L Y 0.878 Pathogenic MLH1 P40692 E178A 178 E A 0.436 Neutral MLH1 P40692 E178C 178 E C 0.578 Pathogenic MLH1 P40692 E178D 178 E D 0.122 Neutral MLH1 P40692 E178F 178 E F 0.848 Pathogenic MLH1 P40692 E178G 178 E G 0.316 Neutral MLH1 P40692 E178H 178 E H 0.584 Pathogenic MLH1 P40692 E178I 178 E I 0.91 Pathogenic MLH1 P40692 E178K 178 E K 0.45 Neutral MLH1 P40692 E178L 178 E L 0.482 Neutral MLH1 P40692 E178M 178 E M 0.702 Pathogenic MLH1 P40692 E178N 178 E N 0.184 Neutral MLH1 P40692 E178P 178 E P 0.866 Pathogenic MLH1 P40692 E178Q 178 E Q 0.198 Neutral MLH1 P40692 E178R 178 E R 0.272 Neutral MLH1 P40692 E178S 178 E S 0.194 Neutral MLH1 P40692 E178T 178 E T 0.388 Neutral MLH1 P40692 E178V 178 E V 0.856 Pathogenic MLH1 P40692 E178W 178 E W 0.922 Pathogenic MLH1 P40692 E178Y 178 E Y 0.888 Pathogenic MLH1 P40692 V179A 179 V A 0.332 Neutral MLH1 P40692 V179C 179 V C 0.698 Pathogenic MLH1 P40692 V179D 179 V D 0.868 Pathogenic MLH1 P40692 V179E 179 V E 0.978 Pathogenic MLH1 P40692 V179F 179 V F 0.862 Pathogenic MLH1 P40692 V179G 179 V G 0.904 Pathogenic MLH1 P40692 V179H 179 V H 0.802 Pathogenic MLH1 P40692 V179I 179 V I 0.16 Neutral MLH1 P40692 V179K 179 V K 0.966 Pathogenic MLH1 P40692 V179L 179 V L 0.194 Neutral MLH1 P40692 V179M 179 V M 0.208 Neutral MLH1 P40692 V179N 179 V N 0.934 Pathogenic MLH1 P40692 V179P 179 V P 0.694 Pathogenic MLH1 P40692 V179Q 179 V Q 0.602 Pathogenic MLH1 P40692 V179R 179 V R 0.694 Pathogenic MLH1 P40692 V179S 179 V S 0.736 Pathogenic MLH1 P40692 V179T 179 V T 0.732 Pathogenic MLH1 P40692 V179W 179 V W 0.896 Pathogenic MLH1 P40692 V179Y 179 V Y 0.92 Pathogenic MLH1 P40692 R18A 18 R A 0.49 Neutral MLH1 P40692 R18C 18 R C 0.764 Pathogenic MLH1 P40692 R18D 18 R D 0.702 Pathogenic MLH1 P40692 R18E 18 R E 0.636 Pathogenic MLH1 P40692 R18F 18 R F 0.92 Pathogenic MLH1 P40692 R18G 18 R G 0.328 Neutral MLH1 P40692 R18H 18 R H 0.442 Neutral MLH1 P40692 R18I 18 R I 0.922 Pathogenic MLH1 P40692 R18K 18 R K 0.394 Neutral MLH1 P40692 R18L 18 R L 0.676 Pathogenic MLH1 P40692 R18M 18 R M 0.68 Pathogenic MLH1 P40692 R18N 18 R N 0.638 Pathogenic MLH1 P40692 R18P 18 R P 0.89 Pathogenic MLH1 P40692 R18Q 18 R Q 0.132 Neutral MLH1 P40692 R18S 18 R S 0.676 Pathogenic MLH1 P40692 R18T 18 R T 0.374 Neutral MLH1 P40692 R18V 18 R V 0.886 Pathogenic MLH1 P40692 R18W 18 R W 0.892 Pathogenic MLH1 P40692 R18Y 18 R Y 0.886 Pathogenic MLH1 P40692 V180A 180 V A 0.072 Neutral MLH1 P40692 V180C 180 V C 0.664 Pathogenic MLH1 P40692 V180D 180 V D 0.854 Pathogenic MLH1 P40692 V180E 180 V E 0.962 Pathogenic MLH1 P40692 V180F 180 V F 0.844 Pathogenic MLH1 P40692 V180G 180 V G 0.906 Pathogenic MLH1 P40692 V180H 180 V H 0.782 Pathogenic MLH1 P40692 V180I 180 V I 0.154 Neutral MLH1 P40692 V180K 180 V K 0.942 Pathogenic MLH1 P40692 V180L 180 V L 0.196 Neutral MLH1 P40692 V180M 180 V M 0.208 Neutral MLH1 P40692 V180N 180 V N 0.924 Pathogenic MLH1 P40692 V180P 180 V P 0.946 Pathogenic MLH1 P40692 V180Q 180 V Q 0.976 Pathogenic MLH1 P40692 V180R 180 V R 0.95 Pathogenic MLH1 P40692 V180S 180 V S 0.718 Pathogenic MLH1 P40692 V180T 180 V T 0.16 Neutral MLH1 P40692 V180W 180 V W 0.892 Pathogenic MLH1 P40692 V180Y 180 V Y 0.676 Pathogenic MLH1 P40692 G181A 181 G A 0.1 Neutral MLH1 P40692 G181C 181 G C 0.566 Pathogenic MLH1 P40692 G181D 181 G D 0.502 Pathogenic MLH1 P40692 G181E 181 G E 0.964 Pathogenic MLH1 P40692 G181F 181 G F 0.956 Pathogenic MLH1 P40692 G181H 181 G H 0.974 Pathogenic MLH1 P40692 G181I 181 G I 0.96 Pathogenic MLH1 P40692 G181K 181 G K 0.662 Pathogenic MLH1 P40692 G181L 181 G L 0.786 Pathogenic MLH1 P40692 G181M 181 G M 0.604 Pathogenic MLH1 P40692 G181N 181 G N 0.66 Pathogenic MLH1 P40692 G181P 181 G P 0.932 Pathogenic MLH1 P40692 G181Q 181 G Q 0.574 Pathogenic MLH1 P40692 G181R 181 G R 0.924 Pathogenic MLH1 P40692 G181S 181 G S 0.104 Neutral MLH1 P40692 G181T 181 G T 0.578 Pathogenic MLH1 P40692 G181V 181 G V 0.956 Pathogenic MLH1 P40692 G181W 181 G W 0.964 Pathogenic MLH1 P40692 G181Y 181 G Y 0.808 Pathogenic MLH1 P40692 R182A 182 R A 0.254 Neutral MLH1 P40692 R182C 182 R C 0.834 Pathogenic MLH1 P40692 R182D 182 R D 0.764 Pathogenic MLH1 P40692 R182E 182 R E 0.704 Pathogenic MLH1 P40692 R182F 182 R F 0.748 Pathogenic MLH1 P40692 R182G 182 R G 0.1 Neutral 1 MLH1 P40692 R182H 182 R H 0.482 Neutral MLH1 P40692 R182I 182 R I 0.95 Pathogenic MLH1 P40692 R182K 182 R K 0.348 Neutral MLH1 P40692 R182L 182 R L 0.65 Pathogenic MLH1 P40692 R182M 182 R M 0.734 Pathogenic MLH1 P40692 R182N 182 R N 0.164 Neutral MLH1 P40692 R182P 182 R P 0.66 Pathogenic MLH1 P40692 R182Q 182 R Q 0.174 Neutral MLH1 P40692 R182S 182 R S 0.14 Neutral MLH1 P40692 R182T 182 R T 0.216 Neutral MLH1 P40692 R182V 182 R V 0.922 Pathogenic MLH1 P40692 R182W 182 R W 0.94 Pathogenic MLH1 P40692 R182Y 182 R Y 0.934 Pathogenic MLH1 P40692 Y183A 183 Y A 0.374 Neutral MLH1 P40692 Y183C 183 Y C 0.604 Pathogenic MLH1 P40692 Y183D 183 Y D 0.78 Pathogenic MLH1 P40692 Y183E 183 Y E 0.688 Pathogenic MLH1 P40692 Y183F 183 Y F 0.128 Neutral MLH1 P40692 Y183G 183 Y G 0.426 Neutral MLH1 P40692 Y183H 183 Y H 0.172 Neutral MLH1 P40692 Y183I 183 Y I 0.298 Neutral MLH1 P40692 Y183K 183 Y K 0.792 Pathogenic MLH1 P40692 Y183L 183 Y L 0.206 Neutral MLH1 P40692 Y183M 183 Y M 0.63 Pathogenic MLH1 P40692 Y183N 183 Y N 0.66 Pathogenic MLH1 P40692 Y183P 183 Y P 0.748 Pathogenic MLH1 P40692 Y183Q 183 Y Q 0.568 Pathogenic MLH1 P40692 Y183R 183 Y R 0.254 Neutral MLH1 P40692 Y183S 183 Y S 0.422 Neutral MLH1 P40692 Y183T 183 Y T 0.596 Pathogenic MLH1 P40692 Y183V 183 Y V 0.758 Pathogenic MLH1 P40692 Y183W 183 Y W 0.852 Pathogenic MLH1 P40692 S184A 184 S A 0.138 Neutral MLH1 P40692 S184C 184 S C 0.782 Pathogenic MLH1 P40692 S184D 184 S D 0.804 Pathogenic MLH1 P40692 S184E 184 S E 0.91 Pathogenic MLH1 P40692 S184F 184 S F 0.976 Pathogenic MLH1 P40692 S184G 184 S G 0.152 Neutral MLH1 P40692 S184H 184 S H 0.924 Pathogenic MLH1 P40692 S184I 184 S I 0.856 Pathogenic MLH1 P40692 S184K 184 S K 0.898 Pathogenic MLH1 P40692 S184L 184 S L 0.568 Pathogenic MLH1 P40692 S184M 184 S M 0.998 Pathogenic MLH1 P40692 S184N 184 S N 0.768 Pathogenic MLH1 P40692 S184P 184 S P 0.918 Pathogenic MLH1 P40692 S184Q 184 S Q 0.872 Pathogenic MLH1 P40692 S184R 184 S R 0.564 Pathogenic MLH1 P40692 S184T 184 S T 0.876 Pathogenic MLH1 P40692 S184V 184 S V 0.798 Pathogenic MLH1 P40692 S184W 184 S W 0.982 Pathogenic MLH1 P40692 S184Y 184 S Y 0.836 Pathogenic MLH1 P40692 V185A 185 V A 0.31 Neutral MLH1 P40692 V185C 185 V C 0.142 Neutral MLH1 P40692 V185D 185 V D 0.49 Neutral MLH1 P40692 V185E 185 V E 0.942 Pathogenic MLH1 P40692 V185F 185 V F 0.816 Pathogenic MLH1 P40692 V185G 185 V G 0.91 Pathogenic 5 MLH1 P40692 V185H 185 V H 0.75 Pathogenic MLH1 P40692 V185I 185 V I 0.162 Neutral MLH1 P40692 V185K 185 V K 0.336 Neutral MLH1 P40692 V185L 185 V L 0.19 Neutral MLH1 P40692 V185M 185 V M 0.726 Pathogenic MLH1 P40692 V185N 185 V N 0.906 Pathogenic MLH1 P40692 V185P 185 V P 0.926 Pathogenic MLH1 P40692 V185Q 185 V Q 0.958 Pathogenic MLH1 P40692 V185R 185 V R 0.936 Pathogenic MLH1 P40692 V185S 185 V S 0.14 Neutral MLH1 P40692 V185T 185 V T 0.67 Pathogenic MLH1 P40692 V185W 185 V W 0.866 Pathogenic MLH1 P40692 V185Y 185 V Y 0.882 Pathogenic MLH1 P40692 H186A 186 H A 0.176 Neutral MLH1 P40692 H186C 186 H C 0.622 Pathogenic MLH1 P40692 H186D 186 H D 0.568 Pathogenic MLH1 P40692 H186E 186 H E 0.27 Neutral MLH1 P40692 H186F 186 H F 0.93 Pathogenic MLH1 P40692 H186G 186 H G 0.506 Pathogenic MLH1 P40692 H186I 186 H I 0.912 Pathogenic MLH1 P40692 H186K 186 H K 0.82 Pathogenic MLH1 P40692 H186L 186 H L 0.632 Pathogenic MLH1 P40692 H186M 186 H M 0.814 Pathogenic MLH1 P40692 H186N 186 H N 0.126 Neutral MLH1 P40692 H186P 186 H P 0.984 Pathogenic MLH1 P40692 H186Q 186 H Q 0.788 Pathogenic MLH1 P40692 H186R 186 H R 0.866 Pathogenic MLH1 P40692 H186S 186 H S 0.382 Neutral MLH1 P40692 H186T 186 H T 0.704 Pathogenic MLH1 P40692 H186V 186 H V 0.246 Neutral MLH1 P40692 H186W 186 H W 0.992 Pathogenic MLH1 P40692 H186Y 186 H Y 0.616 Pathogenic MLH1 P40692 N187A 187 N A 0.53 Pathogenic MLH1 P40692 N187C 187 N C 0.042 Neutral MLH1 P40692 N187D 187 N D 0.58 Pathogenic MLH1 P40692 N187E 187 N E 0.53 Pathogenic MLH1 P40692 N187F 187 N F 0.498 Neutral MLH1 P40692 N187G 187 N G 0.62 Pathogenic MLH1 P40692 N187H 187 N H 0.072 Neutral MLH1 P40692 N187I 187 N I 0.85 Pathogenic MLH1 P40692 N187K 187 N K 0.778 Pathogenic MLH1 P40692 N187L 187 N L 0.282 Neutral MLH1 P40692 N187M 187 N M 0.86 Pathogenic MLH1 P40692 N187P 187 N P 0.768 Pathogenic MLH1 P40692 N187Q 187 N Q 0.268 Neutral MLH1 P40692 N187R 187 N R 0.618 Pathogenic MLH1 P40692 N187S 187 N S 0.032 Neutral MLH1 P40692 N187T 187 N T 0.026 Neutral MLH1 P40692 N187V 187 N V 0.422 Neutral MLH1 P40692 N187W 187 N W 0.95 Pathogenic MLH1 P40692 N187Y 187 N Y 0.72 Pathogenic MLH1 P40692 A188C 188 A C 0.396 Neutral MLH1 P40692 A188D 188 A D 0.582 Pathogenic MLH1 P40692 A188E 188 A E 0.518 Pathogenic MLH1 P40692 A188F 188 A F 0.902 Pathogenic MLH1 P40692 A188G 188 A G 0.11 Neutral MLH1 P40692 A188H 188 A H 0.776 Pathogenic MLH1 P40692 A188I 188 A I 0.588 Pathogenic MLH1 P40692 A188K 188 A K 0.488 Neutral MLH1 P40692 A188L 188 A L 0.878 Pathogenic MLH1 P40692 A188M 188 A M 0.748 Pathogenic MLH1 P40692 A188N 188 A N 0.54 Pathogenic MLH1 P40692 A188P 188 A P 0.098 Neutral MLH1 P40692 A188Q 188 A Q 0.464 Neutral MLH1 P40692 A188R 188 A R 0.538 Pathogenic MLH1 P40692 A188S 188 A S 0.172 Neutral MLH1 P40692 A188T 188 A T 0.054 Neutral MLH1 P40692 A188V 188 A V 0.188 Neutral MLH1 P40692 A188W 188 A W 0.896 Pathogenic MLH1 P40692 A188Y 188 A Y 0.544 Pathogenic MLH1 P40692 G189A 189 G A 0.1 Neutral MLH1 P40692 G189C 189 G C 0.8 Pathogenic MLH1 P40692 G189D 189 G D 0.468 Neutral MLH1 P40692 G189E 189 G E 0.966 Pathogenic MLH1 P40692 G189F 189 G F 0.952 Pathogenic MLH1 P40692 G189H 189 G H 0.604 Pathogenic MLH1 P40692 G189I 189 G I 0.96 Pathogenic MLH1 P40692 G189K 189 G K 0.602 Pathogenic MLH1 P40692 G189L 189 G L 0.626 Pathogenic MLH1 P40692 G189M 189 G M 0.986 Pathogenic MLH1 P40692 G189N 189 G N 0.474 Neutral MLH1 P40692 G189P 189 G P 0.932 Pathogenic MLH1 P40692 G189Q 189 G Q 0.552 Pathogenic MLH1 P40692 G189R 189 G R 0.644 Pathogenic MLH1 P40692 G189S 189 G S 0.102 Neutral MLH1 P40692 G189T 189 G T 0.598 Pathogenic MLH1 P40692 G189V 189 G V 0.974 Pathogenic MLH1 P40692 G189W 189 G W 0.964 Pathogenic MLH1 P40692 G189Y 189 G Y 0.958 Pathogenic MLH1 P40692 I19A 19 I A 0.242 Neutral MLH1 P40692 I19C 19 I C 0.652 Pathogenic MLH1 P40692 I19D 19 I D 0.742 Pathogenic MLH1 P40692 I19E 19 I E 0.748 Pathogenic MLH1 P40692 I19F 19 I F 0.958 Pathogenic MLH1 P40692 I19G 19 I G 0.808 Pathogenic MLH1 P40692 I19H 19 I H 0.892 Pathogenic MLH1 P40692 I19K 19 I K 0.844 Pathogenic MLH1 P40692 I19L 19 I L 0.73 Pathogenic MLH1 P40692 I19M 19 I M 0.71 Pathogenic MLH1 P40692 I19N 19 I N 0.766 Pathogenic MLH1 P40692 I19P 19 I P 0.93 Pathogenic MLH1 P40692 I19Q 19 I Q 0.78 Pathogenic MLH1 P40692 I19R 19 I R 0.864 Pathogenic MLH1 P40692 I19S 19 I S 0.65 Pathogenic MLH1 P40692 I19T 19 I T 0.346 Neutral MLH1 P40692 I19V 19 I V 0.678 Pathogenic MLH1 P40692 I19W 19 I W 0.99 Pathogenic MLH1 P40692 I19Y 19 I Y 0.978 Pathogenic MLH1 P40692 I190A 190 I A 0.052 Neutral MLH1 P40692 I190C 190 I C 0.166 Neutral MLH1 P40692 I190D 190 I D 0.624 Pathogenic MLH1 P40692 I190E 190 I E 0.608 Pathogenic MLH1 P40692 I190F 190 I F 0.528 Pathogenic MLH1 P40692 I190G 190 I G 0.486 Neutral MLH1 P40692 I190H 190 I H 0.508 Pathogenic MLH1 P40692 I190K 190 I K 0.08 Neutral MLH1 P40692 I190L 190 I L 0.364 Neutral MLH1 P40692 I190M 190 I M 0.384 Neutral MLH1 P40692 I190N 190 I N 0.666 Pathogenic MLH1 P40692 I190P 190 I P 0.75 Pathogenic MLH1 P40692 I190Q 190 I Q 0.642 Pathogenic MLH1 P40692 I190R 190 I R 0.822 Pathogenic MLH1 P40692 I190S 190 I S 0.406 Neutral MLH1 P40692 I190T 190 I T 0.022 Neutral MLH1 P40692 I190V 190 I V 0.154 Neutral MLH1 P40692 I190W 190 I W 0.87 Pathogenic MLH1 P40692 I190Y 190 I Y 0.864 Pathogenic MLH1 P40692 S191A 191 S A 0.048 Neutral MLH1 P40692 S191C 191 S C 0.354 Neutral MLH1 P40692 S191D 191 S D 0.584 Pathogenic MLH1 P40692 S191E 191 S E 0.772 Pathogenic MLH1 P40692 S191F 191 S F 0.9 Pathogenic MLH1 P40692 S191G 191 S G 0.022 Neutral MLH1 P40692 S191H 191 S H 0.672 Pathogenic MLH1 P40692 S191I 191 S I 0.662 Pathogenic MLH1 P40692 S191K 191 S K 0.622 Pathogenic MLH1 P40692 S191L 191 S L 0.68 Pathogenic MLH1 P40692 S191M 191 S M 0.976 Pathogenic MLH1 P40692 S191N 191 S N 0.21 Neutral MLH1 P40692 S191P 191 S P 0.692 Pathogenic MLH1 P40692 S191Q 191 S Q 0.724 Pathogenic MLH1 P40692 S191R 191 S R 0.836 Pathogenic MLH1 P40692 S191T 191 S T 0.618 Pathogenic MLH1 P40692 S191V 191 S V 0.82 Pathogenic MLH1 P40692 S191W 191 S W 0.94 Pathogenic MLH1 P40692 S191Y 191 S Y 0.654 Pathogenic MLH1 P40692 F192A 192 F A 0.462 Neutral MLH1 P40692 F192C 192 F C 0.648 Pathogenic MLH1 P40692 F192D 192 F D 0.772 Pathogenic MLH1 P40692 F192E 192 F E 0.492 Neutral MLH1 P40692 F192G 192 F G 0.47 Neutral MLH1 P40692 F192H 192 F H 0.702 Pathogenic MLH1 P40692 F192I 192 F I 0.156 Neutral MLH1 P40692 F192K 192 F K 0.82 Pathogenic MLH1 P40692 F192L 192 F L 0.12 Neutral MLH1 P40692 F192M 192 F M 0.312 Neutral MLH1 P40692 F192N 192 F N 0.688 Pathogenic MLH1 P40692 F192P 192 F P 0.944 Pathogenic MLH1 P40692 F192Q 192 F Q 0.444 Neutral MLH1 P40692 F192R 192 F R 0.542 Pathogenic MLH1 P40692 F192S 192 F S 0.796 Pathogenic MLH1 P40692 F192T 192 F T 0.598 Pathogenic MLH1 P40692 F192V 192 F V 0.192 Neutral MLH1 P40692 F192W 192 F W 0.75 Pathogenic MLH1 P40692 F192Y 192 F Y 0.722 Pathogenic MLH1 P40692 S193A 193 S A 0.05 Neutral MLH1 P40692 S193C 193 S C 0.506 Pathogenic MLH1 P40692 S193D 193 S D 0.546 Pathogenic MLH1 P40692 S193E 193 S E 0.758 Pathogenic MLH1 P40692 S193F 193 S F 0.896 Pathogenic MLH1 P40692 S193G 193 S G 0.192 Neutral MLH1 P40692 S193H 193 S H 0.818 Pathogenic MLH1 P40692 S193I 193 S I 0.36 Neutral MLH1 P40692 S193K 193 S K 0.626 Pathogenic MLH1 P40692 S193L 193 S L 0.168 Neutral MLH1 P40692 S193M 193 S M 0.59 Pathogenic MLH1 P40692 S193N 193 S N 0.494 Neutral MLH1 P40692 S193P 193 S P 0.232 Neutral MLH1 P40692 S193Q 193 S Q 0.584 Pathogenic MLH1 P40692 S193R 193 S R 0.826 Pathogenic MLH1 P40692 S193T 193 S T 0.054 Neutral MLH1 P40692 S193V 193 S V 0.082 Neutral MLH1 P40692 S193W 193 S W 0.954 Pathogenic MLH1 P40692 S193Y 193 S Y 0.936 Pathogenic MLH1 P40692 V194A 194 V A 0.146 Neutral MLH1 P40692 V194C 194 V C 0.09 Neutral MLH1 P40692 V194D 194 V D 0.618 Pathogenic MLH1 P40692 V194E 194 V E 0.722 Pathogenic MLH1 P40692 V194F 194 V F 0.456 Neutral MLH1 P40692 V194G 194 V G 0.64 Pathogenic MLH1 P40692 V194H 194 V H 0.546 Pathogenic MLH1 P40692 V194I 194 V I 0.252 Neutral MLH1 P40692 V194K 194 V K 0.232 Neutral MLH1 P40692 V194L 194 V L 0.052 Neutral MLH1 P40692 V194M 194 V M 0.264 Neutral MLH1 P40692 V194N 194 V N 0.658 Pathogenic MLH1 P40692 V194P 194 V P 0.87 Pathogenic MLH1 P40692 V194Q 194 V Q 0.736 Pathogenic MLH1 P40692 V194R 194 V R 0.842 Pathogenic MLH1 P40692 V194S 194 V S 0.456 Neutral MLH1 P40692 V194T 194 V T 0.408 Neutral MLH1 P40692 V194W 194 V W 0.842 Pathogenic MLH1 P40692 V194Y 194 V Y 0.832 Pathogenic MLH1 P40692 K195A 195 K A 0.54 Pathogenic MLH1 P40692 K195C 195 K C 0.436 Neutral MLH1 P40692 K195D 195 K D 0.606 Pathogenic MLH1 P40692 K195E 195 K E 0.142 Neutral MLH1 P40692 K195F 195 K F 0.964 Pathogenic MLH1 P40692 K195G 195 K G 0.54 Pathogenic MLH1 P40692 K195H 195 K H 0.106 Neutral MLH1 P40692 K195I 195 K I 0.988 Pathogenic MLH1 P40692 K195L 195 K L 0.686 Pathogenic MLH1 P40692 K195M 195 K M 0.922 Pathogenic MLH1 P40692 K195N 195 K N 0.25 Neutral MLH1 P40692 K195P 195 K P 0.922 Pathogenic MLH1 P40692 K195Q 195 K Q 0.274 Neutral MLH1 P40692 K195R 195 K R 0.12 Neutral MLH1 P40692 K195S 195 K S 0.72 Pathogenic MLH1 P40692 K195T 195 K T 0.624 Pathogenic MLH1 P40692 K195V 195 K V 0.878 Pathogenic MLH1 P40692 K195W 195 K W 0.992 Pathogenic MLH1 P40692 K195Y 195 K Y 0.984 Pathogenic MLH1 P40692 K196A 196 K A 0.242 Neutral MLH1 P40692 K196C 196 K C 0.562 Pathogenic MLH1 P40692 K196D 196 K D 0.33 Neutral MLH1 P40692 K196E 196 K E 0.37 Neutral MLH1 P40692 K196F 196 K F 0.842 Pathogenic MLH1 P40692 K196G 196 K G 0.538 Pathogenic MLH1 P40692 K196H 196 K H 0.854 Pathogenic MLH1 P40692 K196I 196 K I 0.99 Pathogenic MLH1 P40692 K196L 196 K L 0.982 Pathogenic MLH1 P40692 K196M 196 K M 0.93 Pathogenic MLH1 P40692 K196N 196 K N 0.77 Pathogenic MLH1 P40692 K196P 196 K P 0.418 Neutral MLH1 P40692 K196Q 196 K Q 0.372 Neutral MLH1 P40692 K196R 196 K R 0.214 Neutral MLH1 P40692 K196S 196 K S 0.728 Pathogenic MLH1 P40692 K196T 196 K T 0.672 Pathogenic MLH1 P40692 K196V 196 K V 0.504 Pathogenic MLH1 P40692 K196W 196 K W 0.992 Pathogenic MLH1 P40692 K196Y 196 K Y 0.984 Pathogenic MLH1 P40692 Q197A 197 Q A 0.1 Neutral MLH1 P40692 Q197C 197 Q C 0.346 Neutral MLH1 P40692 Q197D 197 Q D 0.4 Neutral MLH1 P40692 Q197E 197 Q E 0.592 Pathogenic MLH1 P40692 Q197F 197 Q F 0.294 Neutral MLH1 P40692 Q197G 197 Q G 0.442 Neutral MLH1 P40692 Q197H 197 Q H 0.056 Neutral MLH1 P40692 Q197I 197 Q I 0.316 Neutral MLH1 P40692 Q197K 197 Q K 0.708 Pathogenic MLH1 P40692 Q197L 197 Q L 0.192 Neutral MLH1 P40692 Q197M 197 Q M 0.05 Neutral MLH1 P40692 Q197N 197 Q N 0.434 Neutral MLH1 P40692 Q197P 197 Q P 0.814 Pathogenic MLH1 P40692 Q197R 197 Q R 0.356 Neutral MLH1 P40692 Q197S 197 Q S 0.094 Neutral MLH1 P40692 Q197T 197 Q T 0.04 Neutral MLH1 P40692 Q197V 197 Q V 0.09 Neutral MLH1 P40692 Q197W 197 Q W 0.886 Pathogenic MLH1 P40692 Q197Y 197 Q Y 0.44 Neutral MLH1 P40692 G198A 198 G A 0.792 Pathogenic MLH1 P40692 G198C 198 G C 0.726 Pathogenic MLH1 P40692 G198D 198 G D 0.534 Pathogenic MLH1 P40692 G198E 198 G E 0.794 Pathogenic MLH1 P40692 G198F 198 G F 0.948 Pathogenic MLH1 P40692 G198H 198 G H 0.944 Pathogenic MLH1 P40692 G198I 198 G I 0.83 Pathogenic MLH1 P40692 G198K 198 G K 0.888 Pathogenic MLH1 P40692 G198L 198 G L 0.91 Pathogenic MLH1 P40692 G198M 198 G M 0.964 Pathogenic MLH1 P40692 G198N 198 G N 0.516 Pathogenic MLH1 P40692 G198P 198 G P 0.91 Pathogenic MLH1 P40692 G198Q 198 G Q 0.714 Pathogenic MLH1 P40692 G198R 198 G R 0.67 Pathogenic MLH1 P40692 G198S 198 G S 0.582 Pathogenic MLH1 P40692 G198T 198 G T 0.8 Pathogenic MLH1 P40692 G198V 198 G V 0.902 Pathogenic MLH1 P40692 G198W 198 G W 0.928 Pathogenic MLH1 P40692 G198Y 198 G Y 0.916 Pathogenic MLH1 P40692 E199A 199 E A 0.214 Neutral MLH1 P40692 E199C 199 E C 0.352 Neutral MLH1 P40692 E199D 199 E D 0.018 Neutral MLH1 P40692 E199F 199 E F 0.848 Pathogenic MLH1 P40692 E199G 199 E G 0.026 Neutral MLH1 P40692 E199H 199 E H 0.648 Pathogenic MLH1 P40692 E199I 199 E I 0.858 Pathogenic MLH1 P40692 E199K 199 E K 0.708 Pathogenic MLH1 P40692 E199L 199 E L 0.81 Pathogenic MLH1 P40692 E199M 199 E M 0.666 Pathogenic MLH1 P40692 E199N 199 E N 0.146 Neutral MLH1 P40692 E199P 199 E P 0.868 Pathogenic MLH1 P40692 E199Q 199 E Q 0.014 Neutral MLH1 P40692 E199R 199 E R 0.53 Pathogenic MLH1 P40692 E199S 199 E S 0.072 Neutral MLH1 P40692 E199T 199 E T 0.554 Pathogenic MLH1 P40692 E199V 199 E V 0.738 Pathogenic MLH1 P40692 E199W 199 E W 0.968 Pathogenic MLH1 P40692 E199Y 199 E Y 0.38 Neutral MLH1 P40692 S2A 2 S A 0.01 Neutral MLH1 P40692 S2C 2 S C 0.032 Neutral MLH1 P40692 S2D 2 S D 0.044 Neutral MLH1 P40692 S2E 2 S E 0.148 Neutral MLH1 P40692 S2F 2 S F 0.276 Neutral MLH1 P40692 S2G 2 S G 0.064 Neutral MLH1 P40692 S2H 2 S H 0.238 Neutral MLH1 P40692 S2I 2 S I 0.026 Neutral MLH1 P40692 S2K 2 S K 0.164 Neutral MLH1 P40692 S2L 2 S L 0.028 Neutral MLH1 P40692 S2M 2 S M 0.332 Neutral MLH1 P40692 S2N 2 S N 0.034 Neutral MLH1 P40692 S2P 2 S P 0.116 Neutral MLH1 P40692 S2Q 2 S Q 0.158 Neutral MLH1 P40692 S2R 2 S R 0.248 Neutral MLH1 P40692 S2T 2 S T 0.11 Neutral MLH1 P40692 S2V 2 S V 0.248 Neutral MLH1 P40692 S2W 2 S W 0.49 Neutral MLH1 P40692 S2Y 2 S Y 0.448 Neutral MLH1 P40692 A20C 20 A C 0.978 Pathogenic MLH1 P40692 A20D 20 A D 0.958 Pathogenic MLH1 P40692 A20E 20 A E 0.976 Pathogenic MLH1 P40692 A20F 20 A F 0.996 Pathogenic MLH1 P40692 A20G 20 A G 0.766 Pathogenic MLH1 P40692 A20H 20 A H 0.942 Pathogenic MLH1 P40692 A20I 20 A I 0.968 Pathogenic MLH1 P40692 A20K 20 A K 0.976 Pathogenic MLH1 P40692 A20L 20 A L 1 Pathogenic MLH1 P40692 A20M 20 A M 0.91 Pathogenic MLH1 P40692 A20N 20 A N 0.878 Pathogenic MLH1 P40692 A20P 20 A P 0.978 Pathogenic MLH1 P40692 A20Q 20 A Q 0.894 Pathogenic MLH1 P40692 A20R 20 A R 0.978 Pathogenic MLH1 P40692 A20S 20 A S 0.16 Neutral MLH1 P40692 A20T 20 A T 0.884 Pathogenic MLH1 P40692 A20V 20 A V 0.942 Pathogenic MLH1 P40692 A20W 20 A W 0.996 Pathogenic MLH1 P40692 A20Y 20 A Y 0.972 Pathogenic MLH1 P40692 T200A 200 T A 0.002 Neutral MLH1 P40692 T200C 200 T C 0.11 Neutral MLH1 P40692 T200D 200 T D 0.032 Neutral MLH1 P40692 T200E 200 T E 0.168 Neutral MLH1 P40692 T200F 200 T F 0.384 Neutral MLH1 P40692 T200G 200 T G 0.018 Neutral MLH1 P40692 T200H 200 T H 0.174 Neutral MLH1 P40692 T200I 200 T I 0.062 Neutral MLH1 P40692 T200K 200 T K 0.14 Neutral MLH1 P40692 T200L 200 T L 0.024 Neutral MLH1 P40692 T200M 200 T M 0.196 Neutral MLH1 P40692 T200N 200 T N 0.002 Neutral MLH1 P40692 T200P 200 T P 0.036 Neutral MLH1 P40692 T200Q 200 T Q 0.006 Neutral MLH1 P40692 T200R 200 T R 0.336 Neutral MLH1 P40692 T200S 200 T S 0.002 Neutral MLH1 P40692 T200V 200 T V 0.136 Neutral MLH1 P40692 T200W 200 T W 0.706 Pathogenic MLH1 P40692 T200Y 200 T Y 0.668 Pathogenic MLH1 P40692 V201A 201 V A 0.002 Neutral MLH1 P40692 V201C 201 V C 0.104 Neutral MLH1 P40692 V201D 201 V D 0.194 Neutral MLH1 P40692 V201E 201 V E 0.318 Neutral MLH1 P40692 V201F 201 V F 0.346 Neutral MLH1 P40692 V201G 201 V G 0.234 Neutral MLH1 P40692 V201H 201 V H 0.22 Neutral MLH1 P40692 V201I 201 V I 0.088 Neutral MLH1 P40692 V201K 201 V K 0.266 Neutral MLH1 P40692 V201L 201 V L 0.004 Neutral MLH1 P40692 V201M 201 V M 0.024 Neutral MLH1 P40692 V201N 201 V N 0.212 Neutral MLH1 P40692 V201P 201 V P 0.32 Neutral MLH1 P40692 V201Q 201 V Q 0.078 Neutral MLH1 P40692 V201R 201 V R 0.314 Neutral MLH1 P40692 V201S 201 V S 0.016 Neutral MLH1 P40692 V201T 201 V T 0.01 Neutral MLH1 P40692 V201W 201 V W 0.518 Pathogenic MLH1 P40692 V201Y 201 V Y 0.438 Neutral MLH1 P40692 A202C 202 A C 0.32 Neutral MLH1 P40692 A202D 202 A D 0.452 Neutral MLH1 P40692 A202E 202 A E 0.494 Neutral MLH1 P40692 A202F 202 A F 0.408 Neutral MLH1 P40692 A202G 202 A G 0.008 Neutral MLH1 P40692 A202H 202 A H 0.498 Neutral MLH1 P40692 A202I 202 A I 0.542 Pathogenic MLH1 P40692 A202K 202 A K 0.584 Pathogenic MLH1 P40692 A202L 202 A L 0.486 Neutral MLH1 P40692 A202M 202 A M 0.454 Neutral MLH1 P40692 A202N 202 A N 0.402 Neutral MLH1 P40692 A202P 202 A P 0.06 Neutral MLH1 P40692 A202Q 202 A Q 0.466 Neutral MLH1 P40692 A202R 202 A R 0.576 Pathogenic MLH1 P40692 A202S 202 A S 0.004 Neutral MLH1 P40692 A202T 202 A T 0.024 Neutral MLH1 P40692 A202V 202 A V 0.106 Neutral MLH1 P40692 A202W 202 A W 0.75 Pathogenic MLH1 P40692 A202Y 202 A Y 0.754 Pathogenic MLH1 P40692 D203A 203 D A 0.032 Neutral MLH1 P40692 D203C 203 D C 0.332 Neutral MLH1 P40692 D203E 203 D E 0.022 Neutral MLH1 P40692 D203F 203 D F 0.65 Pathogenic MLH1 P40692 D203G 203 D G 0.028 Neutral MLH1 P40692 D203H 203 D H 0.204 Neutral MLH1 P40692 D203I 203 D I 0.502 Pathogenic MLH1 P40692 D203K 203 D K 0.38 Neutral MLH1 P40692 D203L 203 D L 0.228 Neutral MLH1 P40692 D203M 203 D M 0.398 Neutral MLH1 P40692 D203N 203 D N 0.124 Neutral MLH1 P40692 D203P 203 D P 0.072 Neutral MLH1 P40692 D203Q 203 D Q 0.02 Neutral MLH1 P40692 D203R 203 D R 0.414 Neutral MLH1 P40692 D203S 203 D S 0.006 Neutral MLH1 P40692 D203T 203 D T 0.032 Neutral MLH1 P40692 D203V 203 D V 0.502 Pathogenic MLH1 P40692 D203W 203 D W 0.78 Pathogenic MLH1 P40692 D203Y 203 D Y 0.748 Pathogenic MLH1 P40692 V204A 204 V A 0.114 Neutral MLH1 P40692 V204C 204 V C 0.17 Neutral MLH1 P40692 V204D 204 V D 0.368 Neutral MLH1 P40692 V204E 204 V E 0.434 Neutral MLH1 P40692 V204F 204 V F 0.45 Neutral MLH1 P40692 V204G 204 V G 0.056 Neutral MLH1 P40692 V204H 204 V H 0.284 Neutral MLH1 P40692 V204I 204 V I 0.012 Neutral MLH1 P40692 V204K 204 V K 0.4 Neutral MLH1 P40692 V204L 204 V L 0.006 Neutral MLH1 P40692 V204M 204 V M 0.21 Neutral MLH1 P40692 V204N 204 V N 0.084 Neutral MLH1 P40692 V204P 204 V P 0.466 Neutral MLH1 P40692 V204Q 204 V Q 0.436 Neutral MLH1 P40692 V204R 204 V R 0.616 Pathogenic MLH1 P40692 V204S 204 V S 0.02 Neutral MLH1 P40692 V204T 204 V T 0.01 Neutral MLH1 P40692 V204W 204 V W 0.62 Pathogenic MLH1 P40692 V204Y 204 V Y 0.552 Pathogenic MLH1 P40692 R205A 205 R A 0.05 Neutral MLH1 P40692 R205C 205 R C 0.242 Neutral MLH1 P40692 R205D 205 R D 0.262 Neutral MLH1 P40692 R205E 205 R E 0.202 Neutral MLH1 P40692 R205F 205 R F 0.47 Neutral MLH1 P40692 R205G 205 R G 0.098 Neutral MLH1 P40692 R205H 205 R H 0.246 Neutral MLH1 P40692 R205I 205 R I 0.304 Neutral MLH1 P40692 R205K 205 R K 0.012 Neutral MLH1 P40692 R205L 205 R L 0.164 Neutral MLH1 P40692 R205M 205 R M 0.142 Neutral MLH1 P40692 R205N 205 R N 0.008 Neutral MLH1 P40692 R205P 205 R P 0.062 Neutral MLH1 P40692 R205Q 205 R Q 0.154 Neutral MLH1 P40692 R205S 205 R S 0.018 Neutral MLH1 P40692 R205T 205 R T 0.024 Neutral MLH1 P40692 R205V 205 R V 0.062 Neutral MLH1 P40692 R205W 205 R W 0.62 Pathogenic MLH1 P40692 R205Y 205 R Y 0.546 Pathogenic MLH1 P40692 T206A 206 T A 0.462 Neutral MLH1 P40692 T206C 206 T C 0.598 Pathogenic MLH1 P40692 T206D 206 T D 0.612 Pathogenic MLH1 P40692 T206E 206 T E 0.706 Pathogenic MLH1 P40692 T206F 206 T F 0.79 Pathogenic MLH1 P40692 T206G 206 T G 0.338 Neutral MLH1 P40692 T206H 206 T H 0.468 Neutral MLH1 P40692 T206I 206 T I 0.136 Neutral MLH1 P40692 T206K 206 T K 0.634 Pathogenic MLH1 P40692 T206L 206 T L 0.164 Neutral MLH1 P40692 T206M 206 T M 0.752 Pathogenic MLH1 P40692 T206N 206 T N 0.158 Neutral MLH1 P40692 T206P 206 T P 0.07 Neutral MLH1 P40692 T206Q 206 T Q 0.178 Neutral MLH1 P40692 T206R 206 T R 0.682 Pathogenic MLH1 P40692 T206S 206 T S 0.012 Neutral MLH1 P40692 T206V 206 T V 0.048 Neutral MLH1 P40692 T206W 206 T W 0.94 Pathogenic MLH1 P40692 T206Y 206 T Y 0.936 Pathogenic MLH1 P40692 L207A 207 L A 0.018 Neutral MLH1 P40692 L207C 207 L C 0.202 Neutral MLH1 P40692 L207D 207 L D 0.402 Neutral MLH1 P40692 L207E 207 L E 0.376 Neutral MLH1 P40692 L207F 207 L F 0.514 Pathogenic MLH1 P40692 L207G 207 L G 0.116 Neutral MLH1 P40692 L207H 207 L H 0.196 Neutral MLH1 P40692 L207I 207 L I 0.01 Neutral MLH1 P40692 L207K 207 L K 0.032 Neutral MLH1 P40692 L207M 207 L M 0.31 Neutral MLH1 P40692 L207N 207 L N 0.078 Neutral MLH1 P40692 L207P 207 L P 0.122 Neutral MLH1 P40692 L207Q 207 L Q 0.012 Neutral MLH1 P40692 L207R 207 L R 0.43 Neutral MLH1 P40692 L207S 207 L S 0.026 Neutral MLH1 P40692 L207T 207 L T 0.024 Neutral MLH1 P40692 L207V 207 L V 0.006 Neutral MLH1 P40692 L207W 207 L W 0.674 Pathogenic MLH1 P40692 L207Y 207 L Y 0.634 Pathogenic MLH1 P40692 P208A 208 P A 0.094 Neutral MLH1 P40692 P208C 208 P C 0.534 Pathogenic MLH1 P40692 P208D 208 P D 0.312 Neutral MLH1 P40692 P208E 208 P E 0.608 Pathogenic MLH1 P40692 P208F 208 P F 0.778 Pathogenic MLH1 P40692 P208G 208 P G 0.066 Neutral MLH1 P40692 P208H 208 P H 0.484 Neutral MLH1 P40692 P208I 208 P I 0.35 Neutral MLH1 P40692 P208K 208 P K 0.566 Pathogenic MLH1 P40692 P208L 208 P L 0.116 Neutral MLH1 P40692 P208M 208 P M 0.626 Pathogenic MLH1 P40692 P208N 208 P N 0.05 Neutral MLH1 P40692 P208Q 208 P Q 0.124 Neutral MLH1 P40692 P208R 208 P R 0.768 Pathogenic MLH1 P40692 P208S 208 P S 0.054 Neutral MLH1 P40692 P208T 208 P T 0.07 Neutral MLH1 P40692 P208V 208 P V 0.092 Neutral MLH1 P40692 P208W 208 P W 0.804 Pathogenic MLH1 P40692 P208Y 208 P Y 0.494 Neutral MLH1 P40692 N209A 209 N A 0.018 Neutral MLH1 P40692 N209C 209 N C 0.232 Neutral MLH1 P40692 N209D 209 N D 0.02 Neutral MLH1 P40692 N209E 209 N E 0.028 Neutral MLH1 P40692 N209F 209 N F 0.712 Pathogenic MLH1 P40692 N209G 209 N G 0.04 Neutral MLH1 P40692 N209H 209 N H 0.13 Neutral MLH1 P40692 N209I 209 N I 0.622 Pathogenic MLH1 P40692 N209K 209 N K 0.064 Neutral MLH1 P40692 N209L 209 N L 0.342 Neutral MLH1 P40692 N209M 209 N M 0.282 Neutral MLH1 P40692 N209P 209 N P 0.166 Neutral MLH1 P40692 N209Q 209 N Q 0.036 Neutral MLH1 P40692 N209R 209 N R 0.308 Neutral MLH1 P40692 N209S 209 N S 0.022 Neutral MLH1 P40692 N209T 209 N T 0.018 Neutral MLH1 P40692 N209V 209 N V 0.088 Neutral MLH1 P40692 N209W 209 N W 0.846 Pathogenic MLH1 P40692 N209Y 209 N Y 0.8 Pathogenic MLH1 P40692 A21C 21 A C 0.978 Pathogenic MLH1 P40692 A21D 21 A D 0.958 Pathogenic MLH1 P40692 A21E 21 A E 0.978 Pathogenic 5 MLH1 P40692 A21F 21 A F 0.996 Pathogenic MLH1 P40692 A21G 21 A G 0.764 Pathogenic MLH1 P40692 A21H 21 A H 0.944 Pathogenic MLH1 P40692 A21I 21 A I 0.968 Pathogenic MLH1 P40692 A21K 21 A K 0.976 Pathogenic MLH1 P40692 A21L 21 A L 0.922 Pathogenic MLH1 P40692 A21M 21 A M 0.912 Pathogenic MLH1 P40692 A21N 21 A N 0.876 Pathogenic MLH1 P40692 A21P 21 A P 0.978 Pathogenic MLH1 P40692 A21Q 21 A Q 0.896 Pathogenic MLH1 P40692 A21R 21 A R 0.81 Pathogenic MLH1 P40692 A21S 21 A S 0.572 Pathogenic MLH1 P40692 A21T 21 A T 0.884 Pathogenic MLH1 P40692 A21V 21 A V 0.872 Pathogenic 4 MLH1 P40692 A21W 21 A W 0.996 Pathogenic MLH1 P40692 A21Y 21 A Y 0.972 Pathogenic MLH1 P40692 A210C 210 A C 0.692 Pathogenic MLH1 P40692 A210D 210 A D 0.724 Pathogenic MLH1 P40692 A210E 210 A E 0.858 Pathogenic MLH1 P40692 A210F 210 A F 0.648 Pathogenic MLH1 P40692 A210G 210 A G 0.046 Neutral MLH1 P40692 A210H 210 A H 0.872 Pathogenic MLH1 P40692 A210I 210 A I 0.93 Pathogenic MLH1 P40692 A210K 210 A K 0.916 Pathogenic MLH1 P40692 A210L 210 A L 0.588 Pathogenic MLH1 P40692 A210M 210 A M 0.564 Pathogenic MLH1 P40692 A210N 210 A N 0.788 Pathogenic MLH1 P40692 A210P 210 A P 0.496 Neutral MLH1 P40692 A210Q 210 A Q 0.624 Pathogenic MLH1 P40692 A210R 210 A R 0.926 Pathogenic MLH1 P40692 A210S 210 A S 0.026 Neutral MLH1 P40692 A210T 210 A T 0.056 Neutral MLH1 P40692 A210V 210 A V 0.16 Neutral MLH1 P40692 A210W 210 A W 0.954 Pathogenic MLH1 P40692 A210Y 210 A Y 0.95 Pathogenic MLH1 P40692 S211A 211 S A 0.286 Neutral MLH1 P40692 S211C 211 S C 0.502 Pathogenic MLH1 P40692 S211D 211 S D 0.376 Neutral MLH1 P40692 S211E 211 S E 0.758 Pathogenic MLH1 P40692 S211F 211 S F 0.896 Pathogenic MLH1 P40692 S211G 211 S G 0.39 Neutral MLH1 P40692 S211H 211 S H 0.512 Pathogenic MLH1 P40692 S211I 211 S I 0.596 Pathogenic MLH1 P40692 S211K 211 S K 0.444 Neutral MLH1 P40692 S211L 211 S L 0.646 Pathogenic MLH1 P40692 S211M 211 S M 0.982 Pathogenic MLH1 P40692 S211N 211 S N 0.052 Neutral MLH1 P40692 S211P 211 S P 0.174 Neutral MLH1 P40692 S211Q 211 S Q 0.476 Neutral MLH1 P40692 S211R 211 S R 0.586 Pathogenic MLH1 P40692 S211T 211 S T 0.212 Neutral MLH1 P40692 S211V 211 S V 0.1 Neutral MLH1 P40692 S211W 211 S W 0.954 Pathogenic MLH1 P40692 S211Y 211 S Y 0.936 Pathogenic MLH1 P40692 T212A 212 T A 0.12 Neutral MLH1 P40692 T212C 212 T C 0.09 Neutral MLH1 P40692 T212D 212 T D 0.108 Neutral MLH1 P40692 T212E 212 T E 0.042 Neutral MLH1 P40692 T212F 212 T F 0.306 Neutral MLH1 P40692 T212G 212 T G 0.104 Neutral MLH1 P40692 T212H 212 T H 0.078 Neutral MLH1 P40692 T212I 212 T I 0.048 Neutral MLH1 P40692 T212K 212 T K 0.01 Neutral MLH1 P40692 T212L 212 T L 0.018 Neutral MLH1 P40692 T212M 212 T M 0.054 Neutral MLH1 P40692 T212N 212 T N 0 Neutral MLH1 P40692 T212P 212 T P 0.032 Neutral MLH1 P40692 T212Q 212 T Q 0.004 Neutral MLH1 P40692 T212R 212 T R 0.264 Neutral MLH1 P40692 T212S 212 T S 0 Neutral MLH1 P40692 T212V 212 T V 0.018 Neutral MLH1 P40692 T212W 212 T W 0.742 Pathogenic MLH1 P40692 T212Y 212 T Y 0.472 Neutral MLH1 P40692 V213A 213 V A 0.006 Neutral MLH1 P40692 V213C 213 V C 0.17 Neutral MLH1 P40692 V213D 213 V D 0.154 Neutral MLH1 P40692 V213E 213 V E 0.074 Neutral MLH1 P40692 V213F 213 V F 0.422 Neutral MLH1 P40692 V213G 213 V G 0.22 Neutral MLH1 P40692 V213H 213 V H 0.246 Neutral MLH1 P40692 V213I 213 V I 0.01 Neutral MLH1 P40692 V213K 213 V K 0.092 Neutral MLH1 P40692 V213L 213 V L 0.004 Neutral MLH1 P40692 V213M 213 V M 0.026 Neutral 1 MLH1 P40692 V213N 213 V N 0.084 Neutral MLH1 P40692 V213P 213 V P 0.466 Neutral MLH1 P40692 V213Q 213 V Q 0.078 Neutral MLH1 P40692 V213R 213 V R 0.39 Neutral MLH1 P40692 V213S 213 V S 0.022 Neutral MLH1 P40692 V213T 213 V T 0.01 Neutral MLH1 P40692 V213W 213 V W 0.62 Pathogenic MLH1 P40692 V213Y 213 V Y 0.478 Neutral MLH1 P40692 D214A 214 D A 0.488 Neutral MLH1 P40692 D214C 214 D C 0.728 Pathogenic MLH1 P40692 D214E 214 D E 0.03 Neutral MLH1 P40692 D214F 214 D F 0.928 Pathogenic MLH1 P40692 D214G 214 D G 0.404 Neutral MLH1 P40692 D214H 214 D H 0.084 Neutral MLH1 P40692 D214I 214 D I 0.838 Pathogenic MLH1 P40692 D214K 214 D K 0.732 Pathogenic MLH1 P40692 D214L 214 D L 0.114 Neutral MLH1 P40692 D214M 214 D M 0.798 Pathogenic MLH1 P40692 D214N 214 D N 0.01 Neutral MLH1 P40692 D214P 214 D P 0.756 Pathogenic MLH1 P40692 D214Q 214 D Q 0.462 Neutral MLH1 P40692 D214R 214 D R 0.62 Pathogenic MLH1 P40692 D214S 214 D S 0.02 Neutral MLH1 P40692 D214T 214 D T 0.056 Neutral MLH1 P40692 D214V 214 D V 0.912 Pathogenic MLH1 P40692 D214W 214 D W 0.97 Pathogenic MLH1 P40692 D214Y 214 D Y 0.948 Pathogenic MLH1 P40692 N215A 215 N A 0.07 Neutral MLH1 P40692 N215C 215 N C 0.586 Pathogenic MLH1 P40692 N215D 215 N D 0.052 Neutral MLH1 P40692 N215E 215 N E 0.064 Neutral MLH1 P40692 N215F 215 N F 0.91 Pathogenic MLH1 P40692 N215G 215 N G 0.612 Pathogenic MLH1 P40692 N215H 215 N H 0.756 Pathogenic MLH1 P40692 N215I 215 N I 0.862 Pathogenic MLH1 P40692 N215K 215 N K 0.442 Neutral MLH1 P40692 N215L 215 N L 0.826 Pathogenic MLH1 P40692 N215M 215 N M 0.832 Pathogenic MLH1 P40692 N215P 215 N P 0.796 Pathogenic MLH1 P40692 N215Q 215 N Q 0.302 Neutral MLH1 P40692 N215R 215 N R 0.446 Neutral MLH1 P40692 N215S 215 N S 0.284 Neutral MLH1 P40692 N215T 215 N T 0.308 Neutral MLH1 P40692 N215V 215 N V 0.802 Pathogenic MLH1 P40692 N215W 215 N W 0.954 Pathogenic MLH1 P40692 N215Y 215 N Y 0.95 Pathogenic MLH1 P40692 I216A 216 I A 0.292 Neutral MLH1 P40692 I216C 216 I C 0.686 Pathogenic MLH1 P40692 I216D 216 I D 0.756 Pathogenic MLH1 P40692 I216E 216 I E 0.756 Pathogenic MLH1 P40692 I216F 216 I F 0.924 Pathogenic MLH1 P40692 I216G 216 I G 0.824 Pathogenic MLH1 P40692 I216H 216 I H 0.902 Pathogenic MLH1 P40692 I216K 216 I K 0.848 Pathogenic MLH1 P40692 I216L 216 I L 0.158 Neutral MLH1 P40692 I216M 216 I M 0.696 Pathogenic MLH1 P40692 I216N 216 I N 0.778 Pathogenic MLH1 P40692 I216P 216 I P 0.934 Pathogenic MLH1 P40692 I216Q 216 I Q 0.788 Pathogenic MLH1 P40692 I216R 216 I R 0.864 Pathogenic MLH1 P40692 I216S 216 I S 0.66 Pathogenic MLH1 P40692 I216T 216 I T 0.332 Neutral MLH1 P40692 I216V 216 I V 0.1 Neutral MLH1 P40692 I216W 216 I W 0.966 Pathogenic MLH1 P40692 I216Y 216 I Y 0.946 Pathogenic MLH1 P40692 R217A 217 R A 0.192 Neutral MLH1 P40692 R217C 217 R C 0.904 Pathogenic MLH1 P40692 R217D 217 R D 0.832 Pathogenic MLH1 P40692 R217E 217 R E 0.176 Neutral MLH1 P40692 R217F 217 R F 0.96 Pathogenic MLH1 P40692 R217G 217 R G 0.088 Neutral MLH1 P40692 R217H 217 R H 0.36 Neutral MLH1 P40692 R217I 217 R I 0.966 Pathogenic MLH1 P40692 R217K 217 R K 0.346 Neutral MLH1 P40692 R217L 217 R L 0.962 Pathogenic MLH1 P40692 R217M 217 R M 0.776 Pathogenic MLH1 P40692 R217N 217 R N 0.72 Pathogenic MLH1 P40692 R217P 217 R P 0.962 Pathogenic MLH1 P40692 R217Q 217 R Q 0.098 Neutral MLH1 P40692 R217S 217 R S 0.154 Neutral MLH1 P40692 R217T 217 R T 0.378 Neutral MLH1 P40692 R217V 217 R V 0.438 Neutral MLH1 P40692 R217W 217 R W 0.954 Pathogenic MLH1 P40692 R217Y 217 R Y 0.956 Pathogenic MLH1 P40692 S218A 218 S A 0.012 Neutral MLH1 P40692 S218C 218 S C 0.09 Neutral MLH1 P40692 S218D 218 S D 0.118 Neutral MLH1 P40692 S218E 218 S E 0.368 Neutral MLH1 P40692 S218F 218 S F 0.602 Pathogenic MLH1 P40692 S218G 218 S G 0.008 Neutral MLH1 P40692 S218H 218 S H 0.342 Neutral MLH1 P40692 S218I 218 S I 0.22 Neutral MLH1 P40692 S218K 218 S K 0.316 Neutral MLH1 P40692 S218L 218 S L 0.05 Neutral MLH1 P40692 S218M 218 S M 0.44 Neutral MLH1 P40692 S218N 218 S N 0.008 Neutral MLH1 P40692 S218P 218 S P 0.236 Neutral MLH1 P40692 S218Q 218 S Q 0.332 Neutral MLH1 P40692 S218R 218 S R 0.306 Neutral MLH1 P40692 S218T 218 S T 0.018 Neutral MLH1 P40692 S218V 218 S V 0.058 Neutral MLH1 P40692 S218W 218 S W 0.812 Pathogenic MLH1 P40692 S218Y 218 S Y 0.774 Pathogenic MLH1 P40692 I219A 219 I A 0.134 Neutral MLH1 P40692 I219C 219 I C 0.276 Neutral MLH1 P40692 I219D 219 I D 0.624 Pathogenic MLH1 P40692 I219E 219 I E 0.464 Neutral MLH1 P40692 I219F 219 I F 0.686 Pathogenic MLH1 P40692 I219G 219 I G 0.596 Pathogenic MLH1 P40692 I219H 219 I H 0.268 Neutral MLH1 P40692 I219K 219 I K 0.616 Pathogenic MLH1 P40692 I219L 219 I L 0.008 Neutral 1 MLH1 P40692 I219M 219 I M 0.384 Neutral MLH1 P40692 I219N 219 I N 0.666 Pathogenic MLH1 P40692 I219P 219 I P 0.544 Pathogenic MLH1 P40692 I219Q 219 I Q 0.642 Pathogenic MLH1 P40692 I219R 219 I R 0.822 Pathogenic MLH1 P40692 I219S 219 I S 0.406 Neutral MLH1 P40692 I219T 219 I T 0.148 Neutral MLH1 P40692 I219V 219 I V 0.002 Neutral 1 MLH1 P40692 I219W 219 I W 0.87 Pathogenic MLH1 P40692 I219Y 219 I Y 0.864 Pathogenic MLH1 P40692 G22A 22 G A 0.46 Neutral MLH1 P40692 G22C 22 G C 0.936 Pathogenic MLH1 P40692 G22D 22 G D 0.97 Pathogenic MLH1 P40692 G22E 22 G E 0.978 Pathogenic MLH1 P40692 G22F 22 G F 0.98 Pathogenic MLH1 P40692 G22H 22 G H 0.984 Pathogenic MLH1 P40692 G22I 22 G I 0.97 Pathogenic MLH1 P40692 G22K 22 G K 0.984 Pathogenic MLH1 P40692 G22L 22 G L 0.93 Pathogenic MLH1 P40692 G22M 22 G M 0.988 Pathogenic MLH1 P40692 G22N 22 G N 0.944 Pathogenic MLH1 P40692 G22P 22 G P 0.974 Pathogenic MLH1 P40692 G22Q 22 G Q 0.984 Pathogenic MLH1 P40692 G22R 22 G R 0.996 Pathogenic MLH1 P40692 G22S 22 G S 0.642 Pathogenic MLH1 P40692 G22T 22 G T 0.904 Pathogenic MLH1 P40692 G22V 22 G V 0.982 Pathogenic MLH1 P40692 G22W 22 G W 0.976 Pathogenic MLH1 P40692 G22Y 22 G Y 0.976 Pathogenic MLH1 P40692 F220A 220 F A 0.268 Neutral MLH1 P40692 F220C 220 F C 0.32 Neutral MLH1 P40692 F220D 220 F D 0.56 Pathogenic MLH1 P40692 F220E 220 F E 0.66 Pathogenic MLH1 P40692 F220G 220 F G 0.354 Neutral MLH1 P40692 F220H 220 F H 0.02 Neutral MLH1 P40692 F220I 220 F I 0.248 Neutral MLH1 P40692 F220K 220 F K 0.45 Neutral MLH1 P40692 F220L 220 F L 0.144 Neutral MLH1 P40692 F220M 220 F M 0.388 Neutral MLH1 P40692 F220N 220 F N 0.546 Pathogenic MLH1 P40692 F220P 220 F P 0.706 Pathogenic MLH1 P40692 F220Q 220 F Q 0.104 Neutral MLH1 P40692 F220R 220 F R 0.652 Pathogenic MLH1 P40692 F220S 220 F S 0.422 Neutral MLH1 P40692 F220T 220 F T 0.358 Neutral MLH1 P40692 F220V 220 F V 0.348 Neutral MLH1 P40692 F220W 220 F W 0.814 Pathogenic MLH1 P40692 F220Y 220 F Y 0.218 Neutral MLH1 P40692 G221A 221 G A 0.656 Pathogenic MLH1 P40692 G221C 221 G C 0.94 Pathogenic MLH1 P40692 G221D 221 G D 0.976 Pathogenic MLH1 P40692 G221E 221 G E 0.816 Pathogenic MLH1 P40692 G221F 221 G F 0.988 Pathogenic MLH1 P40692 G221H 221 G H 0.992 Pathogenic MLH1 P40692 G221I 221 G I 0.978 Pathogenic MLH1 P40692 G221K 221 G K 0.906 Pathogenic MLH1 P40692 G221L 221 G L 0.988 Pathogenic MLH1 P40692 G221M 221 G M 0.994 Pathogenic MLH1 P40692 G221N 221 G N 0.534 Pathogenic MLH1 P40692 G221P 221 G P 0.982 Pathogenic MLH1 P40692 G221Q 221 G Q 0.988 Pathogenic MLH1 P40692 G221R 221 G R 1 Pathogenic MLH1 P40692 G221S 221 G S 0.342 Neutral MLH1 P40692 G221T 221 G T 0.676 Pathogenic MLH1 P40692 G221V 221 G V 0.99 Pathogenic MLH1 P40692 G221W 221 G W 0.984 Pathogenic MLH1 P40692 G221Y 221 G Y 0.922 Pathogenic MLH1 P40692 N222A 222 N A 0.05 Neutral MLH1 P40692 N222C 222 N C 0.052 Neutral MLH1 P40692 N222D 222 N D 0.582 Pathogenic MLH1 P40692 N222E 222 N E 0.046 Neutral MLH1 P40692 N222F 222 N F 0.892 Pathogenic MLH1 P40692 N222G 222 N G 0.07 Neutral MLH1 P40692 N222H 222 N H 0.058 Neutral MLH1 P40692 N222I 222 N I 0.848 Pathogenic MLH1 P40692 N222K 222 N K 0.204 Neutral MLH1 P40692 N222L 222 N L 0.458 Neutral MLH1 P40692 N222M 222 N M 0.758 Pathogenic MLH1 P40692 N222P 222 N P 0.196 Neutral MLH1 P40692 N222Q 222 N Q 0.048 Neutral MLH1 P40692 N222R 222 N R 0.614 Pathogenic MLH1 P40692 N222S 222 N S 0.03 Neutral MLH1 P40692 N222T 222 N T 0.04 Neutral MLH1 P40692 N222V 222 N V 0.096 Neutral MLH1 P40692 N222W 222 N W 0.914 Pathogenic MLH1 P40692 N222Y 222 N Y 0.892 Pathogenic MLH1 P40692 A223C 223 A C 0.666 Pathogenic MLH1 P40692 A223D 223 A D 0.704 Pathogenic MLH1 P40692 A223E 223 A E 0.83 Pathogenic MLH1 P40692 A223F 223 A F 0.946 Pathogenic MLH1 P40692 A223G 223 A G 0.114 Neutral MLH1 P40692 A223H 223 A H 0.826 Pathogenic MLH1 P40692 A223I 223 A I 0.628 Pathogenic MLH1 P40692 A223K 223 A K 0.566 Pathogenic MLH1 P40692 A223L 223 A L 0.924 Pathogenic MLH1 P40692 A223M 223 A M 0.806 Pathogenic MLH1 P40692 A223N 223 A N 0.576 Pathogenic MLH1 P40692 A223P 223 A P 0.178 Neutral MLH1 P40692 A223Q 223 A Q 0.518 Pathogenic MLH1 P40692 A223R 223 A R 0.894 Pathogenic MLH1 P40692 A223S 223 A S 0.036 Neutral MLH1 P40692 A223T 223 A T 0.058 Neutral MLH1 P40692 A223V 223 A V 0.288 Neutral MLH1 P40692 A223W 223 A W 0.932 Pathogenic MLH1 P40692 A223Y 223 A Y 0.924 Pathogenic MLH1 P40692 V224A 224 V A 0.068 Neutral MLH1 P40692 V224C 224 V C 0.634 Pathogenic MLH1 P40692 V224D 224 V D 0.484 Neutral MLH1 P40692 V224E 224 V E 0.254 Neutral MLH1 P40692 V224F 224 V F 0.614 Pathogenic MLH1 P40692 V224G 224 V G 0.9 Pathogenic MLH1 P40692 V224H 224 V H 0.752 Pathogenic MLH1 P40692 V224I 224 V I 0.14 Neutral MLH1 P40692 V224K 224 V K 0.9 Pathogenic MLH1 P40692 V224L 224 V L 0.172 Neutral MLH1 P40692 V224M 224 V M 0.376 Neutral MLH1 P40692 V224N 224 V N 0.548 Pathogenic MLH1 P40692 V224P 224 V P 0.916 Pathogenic MLH1 P40692 V224Q 224 V Q 0.95 Pathogenic MLH1 P40692 V224R 224 V R 0.93 Pathogenic MLH1 P40692 V224S 224 V S 0.696 Pathogenic MLH1 P40692 V224T 224 V T 0.15 Neutral MLH1 P40692 V224W 224 V W 0.866 Pathogenic MLH1 P40692 V224Y 224 V Y 0.662 Pathogenic MLH1 P40692 S225A 225 S A 0.11 Neutral MLH1 P40692 S225C 225 S C 0.546 Pathogenic MLH1 P40692 S225D 225 S D 0.582 Pathogenic MLH1 P40692 S225E 225 S E 0.62 Pathogenic MLH1 P40692 S225F 225 S F 0.616 Pathogenic MLH1 P40692 S225G 225 S G 0.024 Neutral MLH1 P40692 S225H 225 S H 0.828 Pathogenic MLH1 P40692 S225I 225 S I 0.66 Pathogenic MLH1 P40692 S225K 225 S K 0.448 Neutral MLH1 P40692 S225L 225 S L 0.548 Pathogenic MLH1 P40692 S225M 225 S M 0.976 Pathogenic MLH1 P40692 S225N 225 S N 0.522 Pathogenic MLH1 P40692 S225P 225 S P 0.506 Pathogenic MLH1 P40692 S225Q 225 S Q 0.722 Pathogenic MLH1 P40692 S225R 225 S R 0.676 Pathogenic MLH1 P40692 S225T 225 S T 0.068 Neutral MLH1 P40692 S225V 225 S V 0.126 Neutral MLH1 P40692 S225W 225 S W 0.942 Pathogenic MLH1 P40692 S225Y 225 S Y 0.898 Pathogenic MLH1 P40692 R226A 226 R A 0.346 Neutral MLH1 P40692 R226C 226 R C 0.582 Pathogenic MLH1 P40692 R226D 226 R D 0.582 Pathogenic MLH1 P40692 R226E 226 R E 0.492 Neutral MLH1 P40692 R226F 226 R F 0.756 Pathogenic MLH1 P40692 R226G 226 R G 0.254 Neutral MLH1 P40692 R226H 226 R H 0.426 Neutral MLH1 P40692 R226I 226 R I 0.474 Neutral MLH1 P40692 R226K 226 R K 0.042 Neutral MLH1 P40692 R226L 226 R L 0.352 Neutral 5 MLH1 P40692 R226M 226 R M 0.064 Neutral MLH1 P40692 R226N 226 R N 0.552 Pathogenic MLH1 P40692 R226P 226 R P 0.696 Pathogenic MLH1 P40692 R226Q 226 R Q 0.7 Pathogenic 5 MLH1 P40692 R226S 226 R S 0.452 Neutral MLH1 P40692 R226T 226 R T 0.504 Pathogenic MLH1 P40692 R226V 226 R V 0.698 Pathogenic MLH1 P40692 R226W 226 R W 0.782 Pathogenic MLH1 P40692 R226Y 226 R Y 0.716 Pathogenic MLH1 P40692 E227A 227 E A 0.244 Neutral MLH1 P40692 E227C 227 E C 0.618 Pathogenic MLH1 P40692 E227D 227 E D 0.094 Neutral MLH1 P40692 E227F 227 E F 0.924 Pathogenic MLH1 P40692 E227G 227 E G 0.338 Neutral MLH1 P40692 E227H 227 E H 0.396 Neutral MLH1 P40692 E227I 227 E I 0.962 Pathogenic MLH1 P40692 E227K 227 E K 0.316 Neutral MLH1 P40692 E227L 227 E L 0.474 Neutral MLH1 P40692 E227M 227 E M 0.802 Pathogenic MLH1 P40692 E227N 227 E N 0.07 Neutral MLH1 P40692 E227P 227 E P 0.908 Pathogenic MLH1 P40692 E227Q 227 E Q 0.11 Neutral MLH1 P40692 E227R 227 E R 0.498 Neutral MLH1 P40692 E227S 227 E S 0.136 Neutral MLH1 P40692 E227T 227 E T 0.762 Pathogenic MLH1 P40692 E227V 227 E V 0.66 Pathogenic MLH1 P40692 E227W 227 E W 0.976 Pathogenic MLH1 P40692 E227Y 227 E Y 0.902 Pathogenic MLH1 P40692 L228A 228 L A 0.558 Pathogenic MLH1 P40692 L228C 228 L C 0.678 Pathogenic MLH1 P40692 L228D 228 L D 0.524 Pathogenic MLH1 P40692 L228E 228 L E 0.25 Neutral MLH1 P40692 L228F 228 L F 0.976 Pathogenic MLH1 P40692 L228G 228 L G 0.46 Neutral MLH1 P40692 L228H 228 L H 0.796 Pathogenic MLH1 P40692 L228I 228 L I 0.178 Neutral MLH1 P40692 L228K 228 L K 0.424 Neutral MLH1 P40692 L228M 228 L M 0.456 Neutral MLH1 P40692 L228N 228 L N 0.762 Pathogenic MLH1 P40692 L228P 228 L P 0.496 Neutral MLH1 P40692 L228Q 228 L Q 0.304 Neutral MLH1 P40692 L228R 228 L R 0.988 Pathogenic MLH1 P40692 L228S 228 L S 0.336 Neutral MLH1 P40692 L228T 228 L T 0.582 Pathogenic MLH1 P40692 L228V 228 L V 0.084 Neutral MLH1 P40692 L228W 228 L W 0.94 Pathogenic MLH1 P40692 L228Y 228 L Y 0.83 Pathogenic MLH1 P40692 I229A 229 I A 0.262 Neutral MLH1 P40692 I229C 229 I C 0.41 Neutral MLH1 P40692 I229D 229 I D 0.134 Neutral MLH1 P40692 I229E 229 I E 0.49 Neutral MLH1 P40692 I229F 229 I F 0.322 Neutral MLH1 P40692 I229G 229 I G 0.59 Pathogenic MLH1 P40692 I229H 229 I H 0.474 Neutral MLH1 P40692 I229K 229 I K 0.134 Neutral MLH1 P40692 I229L 229 I L 0.012 Neutral MLH1 P40692 I229M 229 I M 0.052 Neutral MLH1 P40692 I229N 229 I N 0.314 Neutral MLH1 P40692 I229P 229 I P 0.574 Pathogenic MLH1 P40692 I229Q 229 I Q 0.632 Pathogenic MLH1 P40692 I229R 229 I R 0.83 Pathogenic MLH1 P40692 I229S 229 I S 0.466 Neutral MLH1 P40692 I229T 229 I T 0.032 Neutral MLH1 P40692 I229V 229 I V 0.004 Neutral MLH1 P40692 I229W 229 I W 0.904 Pathogenic MLH1 P40692 I229Y 229 I Y 0.902 Pathogenic MLH1 P40692 E23A 23 E A 0.756 Pathogenic MLH1 P40692 E23C 23 E C 0.698 Pathogenic MLH1 P40692 E23D 23 E D 0.816 Pathogenic MLH1 P40692 E23F 23 E F 0.97 Pathogenic MLH1 P40692 E23G 23 E G 0.15 Neutral MLH1 P40692 E23H 23 E H 0.876 Pathogenic MLH1 P40692 E23I 23 E I 0.98 Pathogenic MLH1 P40692 E23K 23 E K 0.982 Pathogenic MLH1 P40692 E23L 23 E L 0.98 Pathogenic MLH1 P40692 E23M 23 E M 0.924 Pathogenic MLH1 P40692 E23N 23 E N 0.692 Pathogenic MLH1 P40692 E23P 23 E P 0.934 Pathogenic MLH1 P40692 E23Q 23 E Q 0.776 Pathogenic MLH1 P40692 E23R 23 E R 0.888 Pathogenic MLH1 P40692 E23S 23 E S 0.34 Neutral MLH1 P40692 E23T 23 E T 0.878 Pathogenic MLH1 P40692 E23V 23 E V 0.916 Pathogenic MLH1 P40692 E23W 23 E W 0.986 Pathogenic MLH1 P40692 E23Y 23 E Y 0.966 Pathogenic MLH1 P40692 E230A 230 E A 0.29 Neutral MLH1 P40692 E230C 230 E C 0.45 Neutral MLH1 P40692 E230D 230 E D 0.036 Neutral MLH1 P40692 E230F 230 E F 0.81 Pathogenic MLH1 P40692 E230G 230 E G 0.072 Neutral MLH1 P40692 E230H 230 E H 0.072 Neutral MLH1 P40692 E230I 230 E I 0.872 Pathogenic MLH1 P40692 E230K 230 E K 0.082 Neutral MLH1 P40692 E230L 230 E L 0.526 Pathogenic MLH1 P40692 E230M 230 E M 0.684 Pathogenic MLH1 P40692 E230N 230 E N 0.082 Neutral MLH1 P40692 E230P 230 E P 0.146 Neutral MLH1 P40692 E230Q 230 E Q 0.032 Neutral MLH1 P40692 E230R 230 E R 0.158 Neutral MLH1 P40692 E230S 230 E S 0.054 Neutral MLH1 P40692 E230T 230 E T 0.068 Neutral MLH1 P40692 E230V 230 E V 0.812 Pathogenic MLH1 P40692 E230W 230 E W 0.936 Pathogenic MLH1 P40692 E230Y 230 E Y 0.89 Pathogenic MLH1 P40692 I231A 231 I A 0.05 Neutral MLH1 P40692 I231C 231 I C 0.378 Neutral MLH1 P40692 I231D 231 I D 0.268 Neutral MLH1 P40692 I231E 231 I E 0.56 Pathogenic MLH1 P40692 I231F 231 I F 0.162 Neutral MLH1 P40692 I231G 231 I G 0.552 Pathogenic MLH1 P40692 I231H 231 I H 0.436 Neutral MLH1 P40692 I231K 231 I K 0.258 Neutral MLH1 P40692 I231L 231 I L 0.008 Neutral MLH1 P40692 I231M 231 I M 0.42 Neutral MLH1 P40692 I231N 231 I N 0.62 Pathogenic MLH1 P40692 I231P 231 I P 0.708 Pathogenic MLH1 P40692 I231Q 231 I Q 0.596 Pathogenic MLH1 P40692 I231R 231 I R 0.784 Pathogenic MLH1 P40692 I231S 231 I S 0.28 Neutral MLH1 P40692 I231T 231 I T 0.032 Neutral MLH1 P40692 I231V 231 I V 0.152 Neutral MLH1 P40692 I231W 231 I W 0.898 Pathogenic MLH1 P40692 I231Y 231 I Y 0.622 Pathogenic MLH1 P40692 G232A 232 G A 0.008 Neutral MLH1 P40692 G232C 232 G C 0.414 Neutral MLH1 P40692 G232D 232 G D 0.25 Neutral MLH1 P40692 G232E 232 G E 0.354 Neutral MLH1 P40692 G232F 232 G F 0.8 Pathogenic MLH1 P40692 G232H 232 G H 0.466 Neutral MLH1 P40692 G232I 232 G I 0.754 Pathogenic MLH1 P40692 G232K 232 G K 0.43 Neutral MLH1 P40692 G232L 232 G L 0.574 Pathogenic MLH1 P40692 G232M 232 G M 0.734 Pathogenic MLH1 P40692 G232N 232 G N 0.286 Neutral MLH1 P40692 G232P 232 G P 0.482 Neutral MLH1 P40692 G232Q 232 G Q 0.336 Neutral MLH1 P40692 G232R 232 G R 0.464 Neutral MLH1 P40692 G232S 232 G S 0.026 Neutral MLH1 P40692 G232T 232 G T 0.402 Neutral MLH1 P40692 G232V 232 G V 0.454 Neutral MLH1 P40692 G232W 232 G W 0.806 Pathogenic MLH1 P40692 G232Y 232 G Y 0.78 Pathogenic MLH1 P40692 C233A 233 C A 0.012 Neutral MLH1 P40692 C233D 233 C D 0.014 Neutral MLH1 P40692 C233E 233 C E 0.144 Neutral MLH1 P40692 C233F 233 C F 0.416 Neutral MLH1 P40692 C233G 233 C G 0.004 Neutral MLH1 P40692 C233H 233 C H 0.144 Neutral MLH1 P40692 C233I 233 C I 0.086 Neutral MLH1 P40692 C233K 233 C K 0.082 Neutral MLH1 P40692 C233L 233 C L 0.04 Neutral MLH1 P40692 C233M 233 C M 0.032 Neutral MLH1 P40692 C233N 233 C N 0 Neutral MLH1 P40692 C233P 233 C P 0.45 Neutral MLH1 P40692 C233Q 233 C Q 0.216 Neutral MLH1 P40692 C233R 233 C R 0.398 Neutral MLH1 P40692 C233S 233 C S 0.032 Neutral MLH1 P40692 C233T 233 C T 0 Neutral MLH1 P40692 C233V 233 C V 0.02 Neutral MLH1 P40692 C233W 233 C W 0.73 Pathogenic MLH1 P40692 C233Y 233 C Y 0.402 Neutral MLH1 P40692 E234A 234 E A 0.16 Neutral MLH1 P40692 E234C 234 E C 0.354 Neutral MLH1 P40692 E234D 234 E D 0.026 Neutral MLH1 P40692 E234F 234 E F 0.108 Neutral MLH1 P40692 E234G 234 E G 0.048 Neutral MLH1 P40692 E234H 234 E H 0.492 Neutral MLH1 P40692 E234I 234 E I 0.296 Neutral MLH1 P40692 E234K 234 E K 0.036 Neutral MLH1 P40692 E234L 234 E L 0.774 Pathogenic MLH1 P40692 E234M 234 E M 0.628 Pathogenic MLH1 P40692 E234N 234 E N 0.032 Neutral MLH1 P40692 E234P 234 E P 0.392 Neutral MLH1 P40692 E234Q 234 E Q 0.032 Neutral MLH1 P40692 E234R 234 E R 0.12 Neutral MLH1 P40692 E234S 234 E S 0.066 Neutral MLH1 P40692 E234T 234 E T 0.058 Neutral MLH1 P40692 E234V 234 E V 0.09 Neutral MLH1 P40692 E234W 234 E W 0.892 Pathogenic MLH1 P40692 E234Y 234 E Y 0.394 Neutral MLH1 P40692 D235A 235 D A 0.138 Neutral MLH1 P40692 D235C 235 D C 0.676 Pathogenic MLH1 P40692 D235E 235 D E 0.048 Neutral MLH1 P40692 D235F 235 D F 0.406 Neutral MLH1 P40692 D235G 235 D G 0.074 Neutral MLH1 P40692 D235H 235 D H 0.434 Neutral MLH1 P40692 D235I 235 D I 0.21 Neutral MLH1 P40692 D235K 235 D K 0.102 Neutral MLH1 P40692 D235L 235 D L 0.866 Pathogenic MLH1 P40692 D235M 235 D M 0.778 Pathogenic MLH1 P40692 D235N 235 D N 0.016 Neutral MLH1 P40692 D235P 235 D P 0.114 Neutral MLH1 P40692 D235Q 235 D Q 0.482 Neutral MLH1 P40692 D235R 235 D R 0.584 Pathogenic MLH1 P40692 D235S 235 D S 0.018 Neutral MLH1 P40692 D235T 235 D T 0.066 Neutral MLH1 P40692 D235V 235 D V 0.152 Neutral MLH1 P40692 D235W 235 D W 0.968 Pathogenic MLH1 P40692 D235Y 235 D Y 0.95 Pathogenic MLH1 P40692 K236A 236 K A 0.032 Neutral MLH1 P40692 K236C 236 K C 0.056 Neutral MLH1 P40692 K236D 236 K D 0.006 Neutral MLH1 P40692 K236E 236 K E 0.004 Neutral MLH1 P40692 K236F 236 K F 0.356 Neutral MLH1 P40692 K236G 236 K G 0.048 Neutral MLH1 P40692 K236H 236 K H 0.082 Neutral MLH1 P40692 K236I 236 K I 0.188 Neutral MLH1 P40692 K236L 236 K L 0.06 Neutral MLH1 P40692 K236M 236 K M 0.098 Neutral MLH1 P40692 K236N 236 K N 0.008 Neutral MLH1 P40692 K236P 236 K P 0.024 Neutral MLH1 P40692 K236Q 236 K Q 0.01 Neutral MLH1 P40692 K236R 236 K R 0.058 Neutral MLH1 P40692 K236S 236 K S 0.014 Neutral MLH1 P40692 K236T 236 K T 0.016 Neutral MLH1 P40692 K236V 236 K V 0.04 Neutral MLH1 P40692 K236W 236 K W 0.67 Pathogenic MLH1 P40692 K236Y 236 K Y 0.574 Pathogenic MLH1 P40692 T237A 237 T A 0.002 Neutral MLH1 P40692 T237C 237 T C 0.11 Neutral MLH1 P40692 T237D 237 T D 0.032 Neutral MLH1 P40692 T237E 237 T E 0.04 Neutral MLH1 P40692 T237F 237 T F 0.412 Neutral MLH1 P40692 T237G 237 T G 0.004 Neutral MLH1 P40692 T237H 237 T H 0.212 Neutral MLH1 P40692 T237I 237 T I 0.058 Neutral MLH1 P40692 T237K 237 T K 0.024 Neutral MLH1 P40692 T237L 237 T L 0.082 Neutral MLH1 P40692 T237M 237 T M 0.064 Neutral MLH1 P40692 T237N 237 T N 0.002 Neutral MLH1 P40692 T237P 237 T P 0.182 Neutral MLH1 P40692 T237Q 237 T Q 0.006 Neutral MLH1 P40692 T237R 237 T R 0.246 Neutral MLH1 P40692 T237S 237 T S 0.002 Neutral MLH1 P40692 T237V 237 T V 0.026 Neutral MLH1 P40692 T237W 237 T W 0.682 Pathogenic MLH1 P40692 T237Y 237 T Y 0.408 Neutral MLH1 P40692 L238A 238 L A 0.032 Neutral MLH1 P40692 L238C 238 L C 0.072 Neutral MLH1 P40692 L238D 238 L D 0.136 Neutral MLH1 P40692 L238E 238 L E 0.218 Neutral MLH1 P40692 L238F 238 L F 0.166 Neutral MLH1 P40692 L238G 238 L G 0.18 Neutral MLH1 P40692 L238H 238 L H 0.02 Neutral MLH1 P40692 L238I 238 L I 0.078 Neutral MLH1 P40692 L238K 238 L K 0.116 Neutral MLH1 P40692 L238M 238 L M 0.278 Neutral MLH1 P40692 L238N 238 L N 0.12 Neutral MLH1 P40692 L238P 238 L P 0.118 Neutral MLH1 P40692 L238Q 238 L Q 0.11 Neutral MLH1 P40692 L238R 238 L R 0.352 Neutral MLH1 P40692 L238S 238 L S 0.016 Neutral MLH1 P40692 L238T 238 L T 0.044 Neutral MLH1 P40692 L238V 238 L V 0.114 Neutral MLH1 P40692 L238W 238 L W 0.54 Pathogenic MLH1 P40692 L238Y 238 L Y 0.4 Neutral MLH1 P40692 A239C 239 A C 0.24 Neutral MLH1 P40692 A239D 239 A D 0.37 Neutral MLH1 P40692 A239E 239 A E 0.312 Neutral MLH1 P40692 A239F 239 A F 0.51 Pathogenic MLH1 P40692 A239G 239 A G 0.004 Neutral MLH1 P40692 A239H 239 A H 0.256 Neutral MLH1 P40692 A239I 239 A I 0.388 Neutral MLH1 P40692 A239K 239 A K 0.298 Neutral MLH1 P40692 A239L 239 A L 0.408 Neutral MLH1 P40692 A239M 239 A M 0.372 Neutral MLH1 P40692 A239N 239 A N 0.334 Neutral MLH1 P40692 A239P 239 A P 0.37 Neutral MLH1 P40692 A239Q 239 A Q 0.288 Neutral MLH1 P40692 A239R 239 A R 0.322 Neutral MLH1 P40692 A239S 239 A S 0.024 Neutral MLH1 P40692 A239T 239 A T 0.212 Neutral MLH1 P40692 A239V 239 A V 0.046 Neutral MLH1 P40692 A239W 239 A W 0.606 Pathogenic MLH1 P40692 A239Y 239 A Y 0.606 Pathogenic MLH1 P40692 V24A 24 V A 0.142 Neutral MLH1 P40692 V24C 24 V C 0.64 Pathogenic MLH1 P40692 V24D 24 V D 0.852 Pathogenic MLH1 P40692 V24E 24 V E 0.954 Pathogenic MLH1 P40692 V24F 24 V F 0.828 Pathogenic MLH1 P40692 V24G 24 V G 0.912 Pathogenic MLH1 P40692 V24H 24 V H 0.756 Pathogenic MLH1 P40692 V24I 24 V I 0.18 Neutral MLH1 P40692 V24K 24 V K 0.938 Pathogenic MLH1 P40692 V24L 24 V L 0.728 Pathogenic MLH1 P40692 V24M 24 V M 0.736 Pathogenic MLH1 P40692 V24N 24 V N 0.572 Pathogenic MLH1 P40692 V24P 24 V P 0.948 Pathogenic MLH1 P40692 V24Q 24 V Q 0.972 Pathogenic MLH1 P40692 V24R 24 V R 0.946 Pathogenic MLH1 P40692 V24S 24 V S 0.7 Pathogenic MLH1 P40692 V24T 24 V T 0.67 Pathogenic MLH1 P40692 V24W 24 V W 0.878 Pathogenic MLH1 P40692 V24Y 24 V Y 0.668 Pathogenic MLH1 P40692 F240A 240 F A 0.176 Neutral MLH1 P40692 F240C 240 F C 0.182 Neutral MLH1 P40692 F240D 240 F D 0.462 Neutral MLH1 P40692 F240E 240 F E 0.26 Neutral MLH1 P40692 F240G 240 F G 0.278 Neutral MLH1 P40692 F240H 240 F H 0.18 Neutral MLH1 P40692 F240I 240 F I 0.2 Neutral MLH1 P40692 F240K 240 F K 0.254 Neutral MLH1 P40692 F240L 240 F L 0.01 Neutral MLH1 P40692 F240M 240 F M 0.134 Neutral MLH1 P40692 F240N 240 F N 0.472 Neutral MLH1 P40692 F240P 240 F P 0.468 Neutral MLH1 P40692 F240Q 240 F Q 0.448 Neutral MLH1 P40692 F240R 240 F R 0.45 Neutral MLH1 P40692 F240S 240 F S 0.436 Neutral MLH1 P40692 F240T 240 F T 0.464 Neutral MLH1 P40692 F240V 240 F V 0.068 Neutral MLH1 P40692 F240W 240 F W 0.676 Pathogenic MLH1 P40692 F240Y 240 F Y 0.034 Neutral MLH1 P40692 K241A 241 K A 0.034 Neutral MLH1 P40692 K241C 241 K C 0.056 Neutral MLH1 P40692 K241D 241 K D 0.098 Neutral MLH1 P40692 K241E 241 K E 0.004 Neutral MLH1 P40692 K241F 241 K F 0.362 Neutral MLH1 P40692 K241G 241 K G 0.132 Neutral MLH1 P40692 K241H 241 K H 0.082 Neutral MLH1 P40692 K241I 241 K I 0.374 Neutral MLH1 P40692 K241L 241 K L 0.314 Neutral MLH1 P40692 K241M 241 K M 0.266 Neutral MLH1 P40692 K241N 241 K N 0.02 Neutral MLH1 P40692 K241P 241 K P 0.154 Neutral MLH1 P40692 K241Q 241 K Q 0.01 Neutral MLH1 P40692 K241R 241 K R 0.006 Neutral MLH1 P40692 K241S 241 K S 0.016 Neutral MLH1 P40692 K241T 241 K T 0.014 Neutral MLH1 P40692 K241V 241 K V 0.2 Neutral MLH1 P40692 K241W 241 K W 0.676 Pathogenic MLH1 P40692 K241Y 241 K Y 0.584 Pathogenic MLH1 P40692 M242A 242 M A 0.05 Neutral MLH1 P40692 M242C 242 M C 0 Neutral MLH1 P40692 M242D 242 M D 0.262 Neutral MLH1 P40692 M242E 242 M E 0.044 Neutral MLH1 P40692 M242F 242 M F 0.352 Neutral MLH1 P40692 M242G 242 M G 0.16 Neutral MLH1 P40692 M242H 242 M H 0.036 Neutral MLH1 P40692 M242I 242 M I 0.016 Neutral MLH1 P40692 M242K 242 M K 0.164 Neutral MLH1 P40692 M242L 242 M L 0.008 Neutral MLH1 P40692 M242N 242 M N 0.088 Neutral MLH1 P40692 M242P 242 M P 0.104 Neutral MLH1 P40692 M242Q 242 M Q 0.036 Neutral MLH1 P40692 M242R 242 M R 0.268 Neutral MLH1 P40692 M242S 242 M S 0.082 Neutral MLH1 P40692 M242T 242 M T 0.104 Neutral MLH1 P40692 M242V 242 M V 0.026 Neutral MLH1 P40692 M242W 242 M W 0.67 Pathogenic MLH1 P40692 M242Y 242 M Y 0.574 Pathogenic MLH1 P40692 N243A 243 N A 0.054 Neutral MLH1 P40692 N243C 243 N C 0.154 Neutral MLH1 P40692 N243D 243 N D 0.01 Neutral MLH1 P40692 N243E 243 N E 0.016 Neutral MLH1 P40692 N243F 243 N F 0.37 Neutral MLH1 P40692 N243G 243 N G 0.02 Neutral MLH1 P40692 N243H 243 N H 0.022 Neutral MLH1 P40692 N243I 243 N I 0.376 Neutral MLH1 P40692 N243K 243 N K 0.048 Neutral MLH1 P40692 N243L 243 N L 0.35 Neutral MLH1 P40692 N243M 243 N M 0.264 Neutral MLH1 P40692 N243P 243 N P 0.27 Neutral MLH1 P40692 N243Q 243 N Q 0.014 Neutral MLH1 P40692 N243R 243 N R 0.186 Neutral MLH1 P40692 N243S 243 N S 0 Neutral MLH1 P40692 N243T 243 N T 0.144 Neutral MLH1 P40692 N243V 243 N V 0.132 Neutral MLH1 P40692 N243W 243 N W 0.536 Pathogenic MLH1 P40692 N243Y 243 N Y 0.492 Neutral MLH1 P40692 G244A 244 G A 0.274 Neutral MLH1 P40692 G244C 244 G C 0.598 Pathogenic MLH1 P40692 G244D 244 G D 0.96 Pathogenic 5 MLH1 P40692 G244E 244 G E 0.982 Pathogenic MLH1 P40692 G244F 244 G F 0.922 Pathogenic MLH1 P40692 G244H 244 G H 0.992 Pathogenic MLH1 P40692 G244I 244 G I 0.978 Pathogenic MLH1 P40692 G244K 244 G K 0.992 Pathogenic MLH1 P40692 G244L 244 G L 0.922 Pathogenic MLH1 P40692 G244M 244 G M 0.892 Pathogenic MLH1 P40692 G244N 244 G N 0.922 Pathogenic MLH1 P40692 G244P 244 G P 0.932 Pathogenic MLH1 P40692 G244Q 244 G Q 0.718 Pathogenic MLH1 P40692 G244R 244 G R 0.74 Pathogenic MLH1 P40692 G244S 244 G S 0.646 Pathogenic MLH1 P40692 G244T 244 G T 0.816 Pathogenic MLH1 P40692 G244V 244 G V 0.71 Pathogenic MLH1 P40692 G244W 244 G W 0.984 Pathogenic MLH1 P40692 G244Y 244 G Y 0.986 Pathogenic MLH1 P40692 Y245A 245 Y A 0.11 Neutral MLH1 P40692 Y245C 245 Y C 0.334 Neutral MLH1 P40692 Y245D 245 Y D 0.336 Neutral MLH1 P40692 Y245E 245 Y E 0.342 Neutral MLH1 P40692 Y245F 245 Y F 0.02 Neutral MLH1 P40692 Y245G 245 Y G 0.25 Neutral MLH1 P40692 Y245H 245 Y H 0.028 Neutral MLH1 P40692 Y245I 245 Y I 0.41 Neutral MLH1 P40692 Y245K 245 Y K 0.06 Neutral MLH1 P40692 Y245L 245 Y L 0.046 Neutral MLH1 P40692 Y245M 245 Y M 0.09 Neutral MLH1 P40692 Y245N 245 Y N 0.404 Neutral MLH1 P40692 Y245P 245 Y P 0.304 Neutral MLH1 P40692 Y245Q 245 Y Q 0.1 Neutral MLH1 P40692 Y245R 245 Y R 0.148 Neutral MLH1 P40692 Y245S 245 Y S 0.254 Neutral MLH1 P40692 Y245T 245 Y T 0.32 Neutral MLH1 P40692 Y245V 245 Y V 0.074 Neutral MLH1 P40692 Y245W 245 Y W 0.028 Neutral MLH1 P40692 I246A 246 I A 0.048 Neutral MLH1 P40692 I246C 246 I C 0.056 Neutral MLH1 P40692 I246D 246 I D 0.608 Pathogenic MLH1 P40692 I246E 246 I E 0.59 Pathogenic MLH1 P40692 I246F 246 I F 0.152 Neutral MLH1 P40692 I246G 246 I G 0.586 Pathogenic MLH1 P40692 I246H 246 I H 0.464 Neutral MLH1 P40692 I246K 246 I K 0.606 Pathogenic MLH1 P40692 I246L 246 I L 0.012 Neutral MLH1 P40692 I246M 246 I M 0.056 Neutral MLH1 P40692 I246N 246 I N 0.652 Pathogenic MLH1 P40692 I246P 246 I P 0.752 Pathogenic MLH1 P40692 I246Q 246 I Q 0.626 Pathogenic MLH1 P40692 I246R 246 I R 0.78 Pathogenic MLH1 P40692 I246S 246 I S 0.438 Neutral MLH1 P40692 I246T 246 I T 0.038 Neutral MLH1 P40692 I246V 246 I V 0.006 Neutral MLH1 P40692 I246W 246 I W 0.902 Pathogenic MLH1 P40692 I246Y 246 I Y 0.906 Pathogenic MLH1 P40692 S247A 247 S A 0.746 Pathogenic MLH1 P40692 S247C 247 S C 0.486 Neutral MLH1 P40692 S247D 247 S D 0.798 Pathogenic MLH1 P40692 S247E 247 S E 0.676 Pathogenic MLH1 P40692 S247F 247 S F 0.834 Pathogenic MLH1 P40692 S247G 247 S G 0.138 Neutral MLH1 P40692 S247H 247 S H 0.922 Pathogenic MLH1 P40692 S247I 247 S I 0.852 Pathogenic MLH1 P40692 S247K 247 S K 0.896 Pathogenic MLH1 P40692 S247L 247 S L 0.876 Pathogenic MLH1 P40692 S247M 247 S M 0.996 Pathogenic MLH1 P40692 S247N 247 S N 0.368 Neutral MLH1 P40692 S247P 247 S P 0.916 Pathogenic 5 MLH1 P40692 S247Q 247 S Q 0.868 Pathogenic MLH1 P40692 S247R 247 S R 0.704 Pathogenic MLH1 P40692 S247T 247 S T 0.404 Neutral MLH1 P40692 S247V 247 S V 0.948 Pathogenic MLH1 P40692 S247W 247 S W 0.978 Pathogenic MLH1 P40692 S247Y 247 S Y 0.976 Pathogenic MLH1 P40692 N248A 248 N A 0.392 Neutral MLH1 P40692 N248C 248 N C 0.566 Pathogenic MLH1 P40692 N248D 248 N D 0.29 Neutral MLH1 P40692 N248E 248 N E 0.704 Pathogenic MLH1 P40692 N248F 248 N F 0.966 Pathogenic MLH1 P40692 N248G 248 N G 0.198 Neutral MLH1 P40692 N248H 248 N H 0.82 Pathogenic MLH1 P40692 N248I 248 N I 0.946 Pathogenic MLH1 P40692 N248K 248 N K 0.476 Neutral MLH1 P40692 N248L 248 N L 0.962 Pathogenic MLH1 P40692 N248M 248 N M 0.952 Pathogenic MLH1 P40692 N248P 248 N P 0.868 Pathogenic MLH1 P40692 N248Q 248 N Q 0.25 Neutral MLH1 P40692 N248R 248 N R 0.59 Pathogenic MLH1 P40692 N248S 248 N S 0.194 Neutral MLH1 P40692 N248T 248 N T 0.212 Neutral MLH1 P40692 N248V 248 N V 0.982 Pathogenic MLH1 P40692 N248W 248 N W 0.976 Pathogenic MLH1 P40692 N248Y 248 N Y 0.97 Pathogenic MLH1 P40692 A249C 249 A C 0.724 Pathogenic MLH1 P40692 A249D 249 A D 0.854 Pathogenic MLH1 P40692 A249E 249 A E 0.856 Pathogenic MLH1 P40692 A249F 249 A F 0.884 Pathogenic MLH1 P40692 A249G 249 A G 0.504 Pathogenic MLH1 P40692 A249H 249 A H 0.846 Pathogenic MLH1 P40692 A249I 249 A I 0.92 Pathogenic MLH1 P40692 A249K 249 A K 0.84 Pathogenic MLH1 P40692 A249L 249 A L 0.572 Pathogenic MLH1 P40692 A249M 249 A M 0.808 Pathogenic MLH1 P40692 A249N 249 A N 0.76 Pathogenic MLH1 P40692 A249P 249 A P 0.162 Neutral MLH1 P40692 A249Q 249 A Q 0.7 Pathogenic MLH1 P40692 A249R 249 A R 0.864 Pathogenic MLH1 P40692 A249S 249 A S 0.01 Neutral MLH1 P40692 A249T 249 A T 0.044 Neutral MLH1 P40692 A249V 249 A V 0.136 Neutral MLH1 P40692 A249W 249 A W 0.904 Pathogenic MLH1 P40692 A249Y 249 A Y 0.93 Pathogenic MLH1 P40692 I25A 25 I A 0.526 Pathogenic MLH1 P40692 I25C 25 I C 0.64 Pathogenic MLH1 P40692 I25D 25 I D 0.736 Pathogenic MLH1 P40692 I25E 25 I E 0.748 Pathogenic MLH1 P40692 I25F 25 I F 0.96 Pathogenic 4 MLH1 P40692 I25G 25 I G 0.494 Neutral MLH1 P40692 I25H 25 I H 0.89 Pathogenic MLH1 P40692 I25K 25 I K 0.844 Pathogenic MLH1 P40692 I25L 25 I L 0.706 Pathogenic MLH1 P40692 I25M 25 I M 0.69 Pathogenic MLH1 P40692 I25N 25 I N 0.762 Pathogenic MLH1 P40692 I25P 25 I P 0.922 Pathogenic MLH1 P40692 I25Q 25 I Q 0.778 Pathogenic MLH1 P40692 I25R 25 I R 0.868 Pathogenic MLH1 P40692 I25S 25 I S 0.616 Pathogenic MLH1 P40692 I25T 25 I T 0.318 Neutral MLH1 P40692 I25V 25 I V 0.134 Neutral MLH1 P40692 I25W 25 I W 0.986 Pathogenic MLH1 P40692 I25Y 25 I Y 0.976 Pathogenic MLH1 P40692 N250A 250 N A 0.734 Pathogenic MLH1 P40692 N250C 250 N C 0.8 Pathogenic MLH1 P40692 N250D 250 N D 0.232 Neutral MLH1 P40692 N250E 250 N E 0.45 Neutral MLH1 P40692 N250F 250 N F 0.966 Pathogenic MLH1 P40692 N250G 250 N G 0.888 Pathogenic MLH1 P40692 N250H 250 N H 0.846 Pathogenic MLH1 P40692 N250I 250 N I 0.948 Pathogenic MLH1 P40692 N250K 250 N K 0.984 Pathogenic MLH1 P40692 N250L 250 N L 0.966 Pathogenic MLH1 P40692 N250M 250 N M 0.972 Pathogenic MLH1 P40692 N250P 250 N P 0.894 Pathogenic MLH1 P40692 N250Q 250 N Q 0.964 Pathogenic MLH1 P40692 N250R 250 N R 0.622 Pathogenic MLH1 P40692 N250S 250 N S 0.21 Neutral MLH1 P40692 N250T 250 N T 0.528 Pathogenic MLH1 P40692 N250V 250 N V 0.99 Pathogenic MLH1 P40692 N250W 250 N W 0.978 Pathogenic MLH1 P40692 N250Y 250 N Y 0.974 Pathogenic MLH1 P40692 Y251A 251 Y A 0.206 Neutral MLH1 P40692 Y251C 251 Y C 0.178 Neutral MLH1 P40692 Y251D 251 Y D 0.796 Pathogenic MLH1 P40692 Y251E 251 Y E 0.732 Pathogenic MLH1 P40692 Y251F 251 Y F 0.072 Neutral MLH1 P40692 Y251G 251 Y G 0.382 Neutral MLH1 P40692 Y251H 251 Y H 0.102 Neutral MLH1 P40692 Y251I 251 Y I 0.654 Pathogenic MLH1 P40692 Y251K 251 Y K 0.82 Pathogenic MLH1 P40692 Y251L 251 Y L 0.142 Neutral MLH1 P40692 Y251M 251 Y M 0.596 Pathogenic MLH1 P40692 Y251N 251 Y N 0.258 Neutral MLH1 P40692 Y251P 251 Y P 0.68 Pathogenic MLH1 P40692 Y251Q 251 Y Q 0.302 Neutral MLH1 P40692 Y251R 251 Y R 0.462 Neutral MLH1 P40692 Y251S 251 Y S 0.236 Neutral MLH1 P40692 Y251T 251 Y T 0.272 Neutral MLH1 P40692 Y251V 251 Y V 0.212 Neutral MLH1 P40692 Y251W 251 Y W 0.214 Neutral MLH1 P40692 S252A 252 S A 0.05 Neutral MLH1 P40692 S252C 252 S C 0.454 Neutral MLH1 P40692 S252D 252 S D 0.494 Neutral MLH1 P40692 S252E 252 S E 0.736 Pathogenic MLH1 P40692 S252F 252 S F 0.884 Pathogenic MLH1 P40692 S252G 252 S G 0.214 Neutral MLH1 P40692 S252H 252 S H 0.472 Neutral MLH1 P40692 S252I 252 S I 0.36 Neutral MLH1 P40692 S252K 252 S K 0.546 Pathogenic MLH1 P40692 S252L 252 S L 0.528 Pathogenic MLH1 P40692 S252M 252 S M 0.976 Pathogenic MLH1 P40692 S252N 252 S N 0.046 Neutral MLH1 P40692 S252P 252 S P 0.494 Neutral MLH1 P40692 S252Q 252 S Q 0.474 Neutral MLH1 P40692 S252R 252 S R 0.588 Pathogenic MLH1 P40692 S252T 252 S T 0.062 Neutral MLH1 P40692 S252V 252 S V 0.102 Neutral MLH1 P40692 S252W 252 S W 0.796 Pathogenic MLH1 P40692 S252Y 252 S Y 0.916 Pathogenic MLH1 P40692 V253A 253 V A 0.048 Neutral MLH1 P40692 V253C 253 V C 0.276 Neutral MLH1 P40692 V253D 253 V D 0.242 Neutral MLH1 P40692 V253E 253 V E 0.648 Pathogenic MLH1 P40692 V253F 253 V F 0.716 Pathogenic MLH1 P40692 V253G 253 V G 0.18 Neutral MLH1 P40692 V253H 253 V H 0.48 Neutral MLH1 P40692 V253I 253 V I 0.114 Neutral MLH1 P40692 V253K 253 V K 0.266 Neutral MLH1 P40692 V253L 253 V L 0.11 Neutral MLH1 P40692 V253M 253 V M 0.078 Neutral MLH1 P40692 V253N 253 V N 0.108 Neutral MLH1 P40692 V253P 253 V P 0.466 Neutral MLH1 P40692 V253Q 253 V Q 0.664 Pathogenic MLH1 P40692 V253R 253 V R 0.544 Pathogenic MLH1 P40692 V253S 253 V S 0.072 Neutral MLH1 P40692 V253T 253 V T 0.056 Neutral MLH1 P40692 V253W 253 V W 0.8 Pathogenic MLH1 P40692 V253Y 253 V Y 0.67 Pathogenic MLH1 P40692 K254A 254 K A 0.158 Neutral MLH1 P40692 K254C 254 K C 0.43 Neutral MLH1 P40692 K254D 254 K D 0.24 Neutral MLH1 P40692 K254E 254 K E 0.726 Pathogenic MLH1 P40692 K254F 254 K F 0.966 Pathogenic MLH1 P40692 K254G 254 K G 0.296 Neutral MLH1 P40692 K254H 254 K H 0.268 Neutral MLH1 P40692 K254I 254 K I 0.982 Pathogenic MLH1 P40692 K254L 254 K L 0.97 Pathogenic MLH1 P40692 K254M 254 K M 0.914 Pathogenic MLH1 P40692 K254N 254 K N 0.264 Neutral MLH1 P40692 K254P 254 K P 0.658 Pathogenic MLH1 P40692 K254Q 254 K Q 0.296 Neutral MLH1 P40692 K254R 254 K R 0.142 Neutral MLH1 P40692 K254S 254 K S 0.356 Neutral MLH1 P40692 K254T 254 K T 0.62 Pathogenic MLH1 P40692 K254V 254 K V 0.872 Pathogenic MLH1 P40692 K254W 254 K W 0.992 Pathogenic MLH1 P40692 K254Y 254 K Y 0.986 Pathogenic MLH1 P40692 K255A 255 K A 0.104 Neutral MLH1 P40692 K255C 255 K C 0.18 Neutral MLH1 P40692 K255D 255 K D 0.27 Neutral MLH1 P40692 K255E 255 K E 0.308 Neutral MLH1 P40692 K255F 255 K F 0.118 Neutral MLH1 P40692 K255G 255 K G 0.108 Neutral MLH1 P40692 K255H 255 K H 0.334 Neutral MLH1 P40692 K255I 255 K I 0.762 Pathogenic MLH1 P40692 K255L 255 K L 0.242 Neutral MLH1 P40692 K255M 255 K M 0.086 Neutral MLH1 P40692 K255N 255 K N 0.184 Neutral MLH1 P40692 K255P 255 K P 0.098 Neutral MLH1 P40692 K255Q 255 K Q 0.136 Neutral MLH1 P40692 K255R 255 K R 0.044 Neutral MLH1 P40692 K255S 255 K S 0.04 Neutral MLH1 P40692 K255T 255 K T 0.046 Neutral MLH1 P40692 K255V 255 K V 0.69 Pathogenic MLH1 P40692 K255W 255 K W 0.976 Pathogenic MLH1 P40692 K255Y 255 K Y 0.92 Pathogenic MLH1 P40692 C256A 256 C A 0.096 Neutral MLH1 P40692 C256D 256 C D 0.112 Neutral MLH1 P40692 C256E 256 C E 0.208 Neutral MLH1 P40692 C256F 256 C F 0.408 Neutral MLH1 P40692 C256G 256 C G 0.004 Neutral MLH1 P40692 C256H 256 C H 0.39 Neutral MLH1 P40692 C256I 256 C I 0.084 Neutral MLH1 P40692 C256K 256 C K 0.316 Neutral MLH1 P40692 C256L 256 C L 0.104 Neutral MLH1 P40692 C256M 256 C M 0.03 Neutral MLH1 P40692 C256N 256 C N 0.038 Neutral MLH1 P40692 C256P 256 C P 0.176 Neutral MLH1 P40692 C256Q 256 C Q 0.036 Neutral MLH1 P40692 C256R 256 C R 0.326 Neutral MLH1 P40692 C256S 256 C S 0.014 Neutral MLH1 P40692 C256T 256 C T 0.004 Neutral MLH1 P40692 C256V 256 C V 0.13 Neutral MLH1 P40692 C256W 256 C W 0.73 Pathogenic MLH1 P40692 C256Y 256 C Y 0.696 Pathogenic MLH1 P40692 I257A 257 I A 0.22 Neutral MLH1 P40692 I257C 257 I C 0.364 Neutral MLH1 P40692 I257D 257 I D 0.312 Neutral MLH1 P40692 I257E 257 I E 0.532 Pathogenic MLH1 P40692 I257F 257 I F 0.63 Pathogenic MLH1 P40692 I257G 257 I G 0.408 Neutral MLH1 P40692 I257H 257 I H 0.046 Neutral MLH1 P40692 I257K 257 I K 0.532 Pathogenic MLH1 P40692 I257L 257 I L 0.012 Neutral MLH1 P40692 I257M 257 I M 0.04 Neutral MLH1 P40692 I257N 257 I N 0.158 Neutral MLH1 P40692 I257P 257 I P 0.114 Neutral MLH1 P40692 I257Q 257 I Q 0.142 Neutral MLH1 P40692 I257R 257 I R 0.774 Pathogenic MLH1 P40692 I257S 257 I S 0.108 Neutral MLH1 P40692 I257T 257 I T 0.03 Neutral MLH1 P40692 I257V 257 I V 0.01 Neutral MLH1 P40692 I257W 257 I W 0.844 Pathogenic MLH1 P40692 I257Y 257 I Y 0.842 Pathogenic MLH1 P40692 F258A 258 F A 0.246 Neutral MLH1 P40692 F258C 258 F C 0.262 Neutral MLH1 P40692 F258D 258 F D 0.498 Neutral MLH1 P40692 F258E 258 F E 0.296 Neutral MLH1 P40692 F258G 258 F G 0.34 Neutral MLH1 P40692 F258H 258 F H 0.292 Neutral MLH1 P40692 F258I 258 F I 0.072 Neutral MLH1 P40692 F258K 258 F K 0.576 Pathogenic MLH1 P40692 F258L 258 F L 0.024 Neutral MLH1 P40692 F258M 258 F M 0.036 Neutral MLH1 P40692 F258N 258 F N 0.514 Pathogenic MLH1 P40692 F258P 258 F P 0.1 Neutral MLH1 P40692 F258Q 258 F Q 0.556 Pathogenic MLH1 P40692 F258R 258 F R 0.528 Pathogenic MLH1 P40692 F258S 258 F S 0.44 Neutral MLH1 P40692 F258T 258 F T 0.092 Neutral MLH1 P40692 F258V 258 F V 0.462 Neutral MLH1 P40692 F258W 258 F W 0.73 Pathogenic MLH1 P40692 F258Y 258 F Y 0.548 Pathogenic MLH1 P40692 L259A 259 L A 0.196 Neutral MLH1 P40692 L259C 259 L C 0.27 Neutral MLH1 P40692 L259D 259 L D 0.912 Pathogenic MLH1 P40692 L259E 259 L E 0.508 Pathogenic MLH1 P40692 L259F 259 L F 0.502 Pathogenic MLH1 P40692 L259G 259 L G 0.802 Pathogenic MLH1 P40692 L259H 259 L H 0.766 Pathogenic MLH1 P40692 L259I 259 L I 0.128 Neutral MLH1 P40692 L259K 259 L K 0.408 Neutral MLH1 P40692 L259M 259 L M 0.444 Neutral MLH1 P40692 L259N 259 L N 0.788 Pathogenic MLH1 P40692 L259P 259 L P 0.678 Pathogenic MLH1 P40692 L259Q 259 L Q 0.604 Pathogenic MLH1 P40692 L259R 259 L R 0.996 Pathogenic MLH1 P40692 L259S 259 L S 0.34 Neutral MLH1 P40692 L259T 259 L T 0.182 Neutral MLH1 P40692 L259V 259 L V 0.082 Neutral MLH1 P40692 L259W 259 L W 0.854 Pathogenic MLH1 P40692 L259Y 259 L Y 0.812 Pathogenic MLH1 P40692 Q26A 26 Q A 0.374 Neutral MLH1 P40692 Q26C 26 Q C 0.444 Neutral MLH1 P40692 Q26D 26 Q D 0.488 Neutral MLH1 P40692 Q26E 26 Q E 0.592 Pathogenic MLH1 P40692 Q26F 26 Q F 0.824 Pathogenic MLH1 P40692 Q26G 26 Q G 0.44 Neutral MLH1 P40692 Q26H 26 Q H 0.066 Neutral MLH1 P40692 Q26I 26 Q I 0.322 Neutral MLH1 P40692 Q26K 26 Q K 0.762 Pathogenic MLH1 P40692 Q26L 26 Q L 0.786 Pathogenic MLH1 P40692 Q26M 26 Q M 0.724 Pathogenic MLH1 P40692 Q26N 26 Q N 0.374 Neutral MLH1 P40692 Q26P 26 Q P 0.848 Pathogenic MLH1 P40692 Q26R 26 Q R 0.524 Pathogenic MLH1 P40692 Q26S 26 Q S 0.666 Pathogenic MLH1 P40692 Q26T 26 Q T 0.516 Pathogenic MLH1 P40692 Q26V 26 Q V 0.088 Neutral MLH1 P40692 Q26W 26 Q W 0.93 Pathogenic MLH1 P40692 Q26Y 26 Q Y 0.89 Pathogenic MLH1 P40692 L260A 260 L A 0.186 Neutral MLH1 P40692 L260C 260 L C 0.104 Neutral MLH1 P40692 L260D 260 L D 0.528 Pathogenic MLH1 P40692 L260E 260 L E 0.502 Pathogenic MLH1 P40692 L260F 260 L F 0.446 Neutral MLH1 P40692 L260G 260 L G 0.464 Neutral MLH1 P40692 L260H 260 L H 0.802 Pathogenic MLH1 P40692 L260I 260 L I 0.178 Neutral MLH1 P40692 L260K 260 L K 0.746 Pathogenic MLH1 P40692 L260M 260 L M 0.456 Neutral MLH1 P40692 L260N 260 L N 0.772 Pathogenic MLH1 P40692 L260P 260 L P 0.998 Pathogenic MLH1 P40692 L260Q 260 L Q 0.618 Pathogenic MLH1 P40692 L260R 260 L R 0.71 Pathogenic 5 MLH1 P40692 L260S 260 L S 0.61 Pathogenic MLH1 P40692 L260T 260 L T 0.33 Neutral MLH1 P40692 L260V 260 L V 0.314 Neutral MLH1 P40692 L260W 260 L W 0.934 Pathogenic MLH1 P40692 L260Y 260 L Y 0.894 Pathogenic MLH1 P40692 F261A 261 F A 0.246 Neutral MLH1 P40692 F261C 261 F C 0.308 Neutral MLH1 P40692 F261D 261 F D 0.802 Pathogenic MLH1 P40692 F261E 261 F E 0.85 Pathogenic MLH1 P40692 F261G 261 F G 0.512 Pathogenic MLH1 P40692 F261H 261 F H 0.76 Pathogenic MLH1 P40692 F261I 261 F I 0.3 Neutral MLH1 P40692 F261K 261 F K 0.838 Pathogenic MLH1 P40692 F261L 261 F L 0.692 Pathogenic MLH1 P40692 F261M 261 F M 0.78 Pathogenic MLH1 P40692 F261N 261 F N 0.74 Pathogenic MLH1 P40692 F261P 261 F P 0.48 Neutral MLH1 P40692 F261Q 261 F Q 0.752 Pathogenic MLH1 P40692 F261R 261 F R 0.902 Pathogenic MLH1 P40692 F261S 261 F S 0.864 Pathogenic MLH1 P40692 F261T 261 F T 0.592 Pathogenic MLH1 P40692 F261V 261 F V 0.792 Pathogenic MLH1 P40692 F261W 261 F W 0.868 Pathogenic MLH1 P40692 F261Y 261 F Y 0.434 Neutral MLH1 P40692 I262A 262 I A 0.626 Pathogenic MLH1 P40692 I262C 262 I C 0.39 Neutral MLH1 P40692 I262D 262 I D 0.774 Pathogenic MLH1 P40692 I262E 262 I E 0.774 Pathogenic MLH1 P40692 I262F 262 I F 0.456 Neutral MLH1 P40692 I262G 262 I G 0.858 Pathogenic MLH1 P40692 I262H 262 I H 0.9 Pathogenic MLH1 P40692 I262K 262 I K 0.844 Pathogenic MLH1 P40692 I262L 262 I L 0.202 Neutral MLH1 P40692 I262M 262 I M 0.676 Pathogenic MLH1 P40692 I262N 262 I N 0.796 Pathogenic MLH1 P40692 I262P 262 I P 0.93 Pathogenic MLH1 P40692 I262Q 262 I Q 0.804 Pathogenic MLH1 P40692 I262R 262 I R 0.88 Pathogenic MLH1 P40692 I262S 262 I S 0.688 Pathogenic MLH1 P40692 I262T 262 I T 0.328 Neutral MLH1 P40692 I262V 262 I V 0.126 Neutral MLH1 P40692 I262W 262 I W 0.912 Pathogenic MLH1 P40692 I262Y 262 I Y 0.888 Pathogenic MLH1 P40692 N263A 263 N A 0.456 Neutral MLH1 P40692 N263C 263 N C 0.752 Pathogenic MLH1 P40692 N263D 263 N D 0.716 Pathogenic MLH1 P40692 N263E 263 N E 0.594 Pathogenic MLH1 P40692 N263F 263 N F 0.956 Pathogenic MLH1 P40692 N263G 263 N G 0.748 Pathogenic MLH1 P40692 N263H 263 N H 0.858 Pathogenic MLH1 P40692 N263I 263 N I 0.814 Pathogenic MLH1 P40692 N263K 263 N K 0.772 Pathogenic MLH1 P40692 N263L 263 N L 0.956 Pathogenic MLH1 P40692 N263M 263 N M 0.96 Pathogenic MLH1 P40692 N263P 263 N P 0.69 Pathogenic MLH1 P40692 N263Q 263 N Q 0.812 Pathogenic MLH1 P40692 N263R 263 N R 0.95 Pathogenic MLH1 P40692 N263S 263 N S 0.23 Neutral MLH1 P40692 N263T 263 N T 0.516 Pathogenic MLH1 P40692 N263V 263 N V 0.99 Pathogenic MLH1 P40692 N263W 263 N W 0.968 Pathogenic MLH1 P40692 N263Y 263 N Y 0.964 Pathogenic MLH1 P40692 H264A 264 H A 0.18 Neutral MLH1 P40692 H264C 264 H C 0.288 Neutral MLH1 P40692 H264D 264 H D 0.012 Neutral MLH1 P40692 H264E 264 H E 0.076 Neutral MLH1 P40692 H264F 264 H F 0.734 Pathogenic MLH1 P40692 H264G 264 H G 0.088 Neutral MLH1 P40692 H264I 264 H I 0.78 Pathogenic MLH1 P40692 H264K 264 H K 0.608 Pathogenic MLH1 P40692 H264L 264 H L 0.728 Pathogenic MLH1 P40692 H264M 264 H M 0.624 Pathogenic MLH1 P40692 H264N 264 H N 0.016 Neutral MLH1 P40692 H264P 264 H P 0.906 Pathogenic MLH1 P40692 H264Q 264 H Q 0.044 Neutral MLH1 P40692 H264R 264 H R 0.166 Neutral MLH1 P40692 H264S 264 H S 0.418 Neutral MLH1 P40692 H264T 264 H T 0.46 Neutral MLH1 P40692 H264V 264 H V 0.24 Neutral MLH1 P40692 H264W 264 H W 0.954 Pathogenic MLH1 P40692 H264Y 264 H Y 0.782 Pathogenic MLH1 P40692 R265A 265 R A 0.566 Pathogenic MLH1 P40692 R265C 265 R C 0.948 Pathogenic 5 MLH1 P40692 R265D 265 R D 0.184 Neutral MLH1 P40692 R265E 265 R E 0.76 Pathogenic MLH1 P40692 R265F 265 R F 0.956 Pathogenic MLH1 P40692 R265G 265 R G 0.414 Neutral MLH1 P40692 R265H 265 R H 0.306 Neutral 1 MLH1 P40692 R265I 265 R I 0.7 Pathogenic MLH1 P40692 R265K 265 R K 0.47 Neutral MLH1 P40692 R265L 265 R L 0.976 Pathogenic MLH1 P40692 R265M 265 R M 0.746 Pathogenic MLH1 P40692 R265N 265 R N 0.25 Neutral MLH1 P40692 R265P 265 R P 0.976 Pathogenic MLH1 P40692 R265Q 265 R Q 0.458 Neutral MLH1 P40692 R265S 265 R S 0.92 Pathogenic 4 MLH1 P40692 R265T 265 R T 0.344 Neutral MLH1 P40692 R265V 265 R V 0.968 Pathogenic MLH1 P40692 R265W 265 R W 0.942 Pathogenic MLH1 P40692 R265Y 265 R Y 0.94 Pathogenic MLH1 P40692 L266A 266 L A 0.098 Neutral MLH1 P40692 L266C 266 L C 0.102 Neutral MLH1 P40692 L266D 266 L D 0.91 Pathogenic MLH1 P40692 L266E 266 L E 0.888 Pathogenic MLH1 P40692 L266F 266 L F 0.96 Pathogenic MLH1 P40692 L266G 266 L G 0.806 Pathogenic MLH1 P40692 L266H 266 L H 0.806 Pathogenic MLH1 P40692 L266I 266 L I 0.278 Neutral MLH1 P40692 L266K 266 L K 0.746 Pathogenic MLH1 P40692 L266M 266 L M 0.248 Neutral MLH1 P40692 L266N 266 L N 0.238 Neutral MLH1 P40692 L266P 266 L P 0.994 Pathogenic MLH1 P40692 L266Q 266 L Q 0.624 Pathogenic MLH1 P40692 L266R 266 L R 0.712 Pathogenic MLH1 P40692 L266S 266 L S 0.128 Neutral MLH1 P40692 L266T 266 L T 0.33 Neutral MLH1 P40692 L266V 266 L V 0.578 Pathogenic MLH1 P40692 L266W 266 L W 0.928 Pathogenic MLH1 P40692 L266Y 266 L Y 0.824 Pathogenic MLH1 P40692 V267A 267 V A 0.498 Neutral MLH1 P40692 V267C 267 V C 0.8 Pathogenic MLH1 P40692 V267D 267 V D 0.852 Pathogenic MLH1 P40692 V267E 267 V E 0.956 Pathogenic MLH1 P40692 V267F 267 V F 0.932 Pathogenic MLH1 P40692 V267G 267 V G 0.926 Pathogenic MLH1 P40692 V267H 267 V H 0.898 Pathogenic MLH1 P40692 V267I 267 V I 0.278 Neutral MLH1 P40692 V267K 267 V K 0.394 Neutral MLH1 P40692 V267L 267 V L 0.418 Neutral MLH1 P40692 V267M 267 V M 0.908 Pathogenic MLH1 P40692 V267N 267 V N 0.546 Pathogenic MLH1 P40692 V267P 267 V P 0.702 Pathogenic MLH1 P40692 V267Q 267 V Q 0.962 Pathogenic MLH1 P40692 V267R 267 V R 0.946 Pathogenic MLH1 P40692 V267S 267 V S 0.808 Pathogenic MLH1 P40692 V267T 267 V T 0.88 Pathogenic MLH1 P40692 V267W 267 V W 0.956 Pathogenic MLH1 P40692 V267Y 267 V Y 0.976 Pathogenic MLH1 P40692 E268A 268 E A 0.498 Neutral MLH1 P40692 E268C 268 E C 0.48 Neutral MLH1 P40692 E268D 268 E D 0.024 Neutral MLH1 P40692 E268F 268 E F 0.826 Pathogenic MLH1 P40692 E268G 268 E G 0.05 Neutral 1 MLH1 P40692 E268H 268 E H 0.148 Neutral MLH1 P40692 E268I 268 E I 0.888 Pathogenic MLH1 P40692 E268K 268 E K 0.094 Neutral MLH1 P40692 E268L 268 E L 0.846 Pathogenic MLH1 P40692 E268M 268 E M 0.654 Pathogenic MLH1 P40692 E268N 268 E N 0.118 Neutral MLH1 P40692 E268P 268 E P 0.826 Pathogenic MLH1 P40692 E268Q 268 E Q 0.4 Neutral MLH1 P40692 E268R 268 E R 0.608 Pathogenic MLH1 P40692 E268S 268 E S 0.066 Neutral MLH1 P40692 E268T 268 E T 0.06 Neutral MLH1 P40692 E268V 268 E V 0.666 Pathogenic MLH1 P40692 E268W 268 E W 0.936 Pathogenic MLH1 P40692 E268Y 268 E Y 0.882 Pathogenic MLH1 P40692 S269A 269 S A 0.75 Pathogenic MLH1 P40692 S269C 269 S C 0.2 Neutral MLH1 P40692 S269D 269 S D 0.804 Pathogenic MLH1 P40692 S269E 269 S E 0.68 Pathogenic MLH1 P40692 S269F 269 S F 0.978 Pathogenic MLH1 P40692 S269G 269 S G 0.546 Pathogenic MLH1 P40692 S269H 269 S H 0.926 Pathogenic MLH1 P40692 S269I 269 S I 0.776 Pathogenic MLH1 P40692 S269K 269 S K 0.9 Pathogenic MLH1 P40692 S269L 269 S L 0.884 Pathogenic MLH1 P40692 S269M 269 S M 0.998 Pathogenic MLH1 P40692 S269N 269 S N 0.204 Neutral MLH1 P40692 S269P 269 S P 0.616 Pathogenic MLH1 P40692 S269Q 269 S Q 0.592 Pathogenic MLH1 P40692 S269R 269 S R 0.932 Pathogenic MLH1 P40692 S269T 269 S T 0.856 Pathogenic MLH1 P40692 S269V 269 S V 0.512 Pathogenic MLH1 P40692 S269W 269 S W 0.822 Pathogenic MLH1 P40692 S269Y 269 S Y 0.916 Pathogenic MLH1 P40692 R27A 27 R A 0.114 Neutral MLH1 P40692 R27C 27 R C 0.598 Pathogenic MLH1 P40692 R27D 27 R D 0.558 Pathogenic MLH1 P40692 R27E 27 R E 0.476 Neutral MLH1 P40692 R27F 27 R F 0.878 Pathogenic MLH1 P40692 R27G 27 R G 0.108 Neutral MLH1 P40692 R27H 27 R H 0.406 Neutral MLH1 P40692 R27I 27 R I 0.846 Pathogenic MLH1 P40692 R27K 27 R K 0.486 Neutral MLH1 P40692 R27L 27 R L 0.82 Pathogenic MLH1 P40692 R27M 27 R M 0.6 Pathogenic MLH1 P40692 R27N 27 R N 0.436 Neutral MLH1 P40692 R27P 27 R P 0.796 Pathogenic MLH1 P40692 R27Q 27 R Q 0.016 Neutral MLH1 P40692 R27S 27 R S 0.05 Neutral MLH1 P40692 R27T 27 R T 0.488 Neutral MLH1 P40692 R27V 27 R V 0.772 Pathogenic MLH1 P40692 R27W 27 R W 0.868 Pathogenic MLH1 P40692 R27Y 27 R Y 0.834 Pathogenic MLH1 P40692 T270A 270 T A 0.05 Neutral MLH1 P40692 T270C 270 T C 0.442 Neutral MLH1 P40692 T270D 270 T D 0.088 Neutral MLH1 P40692 T270E 270 T E 0.14 Neutral MLH1 P40692 T270F 270 T F 0.688 Pathogenic MLH1 P40692 T270G 270 T G 0.036 Neutral MLH1 P40692 T270H 270 T H 0.45 Neutral MLH1 P40692 T270I 270 T I 0.446 Neutral MLH1 P40692 T270K 270 T K 0.156 Neutral MLH1 P40692 T270L 270 T L 0.082 Neutral MLH1 P40692 T270M 270 T M 0.518 Pathogenic MLH1 P40692 T270N 270 T N 0.008 Neutral MLH1 P40692 T270P 270 T P 0.066 Neutral MLH1 P40692 T270Q 270 T Q 0.048 Neutral MLH1 P40692 T270R 270 T R 0.648 Pathogenic MLH1 P40692 T270S 270 T S 0.012 Neutral MLH1 P40692 T270V 270 T V 0.71 Pathogenic MLH1 P40692 T270W 270 T W 0.914 Pathogenic MLH1 P40692 T270Y 270 T Y 0.908 Pathogenic MLH1 P40692 S271A 271 S A 0.034 Neutral MLH1 P40692 S271C 271 S C 0.334 Neutral MLH1 P40692 S271D 271 S D 0.244 Neutral MLH1 P40692 S271E 271 S E 0.388 Neutral MLH1 P40692 S271F 271 S F 0.73 Pathogenic MLH1 P40692 S271G 271 S G 0.102 Neutral MLH1 P40692 S271H 271 S H 0.51 Pathogenic MLH1 P40692 S271I 271 S I 0.412 Neutral MLH1 P40692 S271K 271 S K 0.396 Neutral MLH1 P40692 S271L 271 S L 0.1 Neutral MLH1 P40692 S271M 271 S M 0.566 Pathogenic MLH1 P40692 S271N 271 S N 0.034 Neutral MLH1 P40692 S271P 271 S P 0.104 Neutral MLH1 P40692 S271Q 271 S Q 0.484 Neutral MLH1 P40692 S271R 271 S R 0.39 Neutral MLH1 P40692 S271T 271 S T 0.046 Neutral MLH1 P40692 S271V 271 S V 0.064 Neutral MLH1 P40692 S271W 271 S W 0.904 Pathogenic MLH1 P40692 S271Y 271 S Y 0.878 Pathogenic MLH1 P40692 L272A 272 L A 0.19 Neutral MLH1 P40692 L272C 272 L C 0.686 Pathogenic MLH1 P40692 L272D 272 L D 0.532 Pathogenic MLH1 P40692 L272E 272 L E 0.192 Neutral MLH1 P40692 L272F 272 L F 0.77 Pathogenic MLH1 P40692 L272G 272 L G 0.814 Pathogenic MLH1 P40692 L272H 272 L H 0.786 Pathogenic MLH1 P40692 L272I 272 L I 0.142 Neutral MLH1 P40692 L272K 272 L K 0.184 Neutral MLH1 P40692 L272M 272 L M 0.178 Neutral MLH1 P40692 L272N 272 L N 0.484 Neutral MLH1 P40692 L272P 272 L P 0.986 Pathogenic MLH1 P40692 L272Q 272 L Q 0.614 Pathogenic MLH1 P40692 L272R 272 L R 0.998 Pathogenic MLH1 P40692 L272S 272 L S 0.608 Pathogenic MLH1 P40692 L272T 272 L T 0.332 Neutral MLH1 P40692 L272V 272 L V 0.094 Neutral MLH1 P40692 L272W 272 L W 0.91 Pathogenic MLH1 P40692 L272Y 272 L Y 0.87 Pathogenic MLH1 P40692 R273A 273 R A 0.212 Neutral MLH1 P40692 R273C 273 R C 0.904 Pathogenic MLH1 P40692 R273D 273 R D 0.23 Neutral MLH1 P40692 R273E 273 R E 0.356 Neutral MLH1 P40692 R273F 273 R F 0.96 Pathogenic MLH1 P40692 R273G 273 R G 0.118 Neutral MLH1 P40692 R273H 273 R H 0.536 Pathogenic MLH1 P40692 R273I 273 R I 0.966 Pathogenic MLH1 P40692 R273K 273 R K 0.598 Pathogenic MLH1 P40692 R273L 273 R L 0.962 Pathogenic MLH1 P40692 R273M 273 R M 0.776 Pathogenic MLH1 P40692 R273N 273 R N 0.72 Pathogenic MLH1 P40692 R273P 273 R P 0.962 Pathogenic MLH1 P40692 R273Q 273 R Q 0.098 Neutral MLH1 P40692 R273S 273 R S 0.192 Neutral MLH1 P40692 R273T 273 R T 0.226 Neutral MLH1 P40692 R273V 273 R V 0.95 Pathogenic MLH1 P40692 R273W 273 R W 0.956 Pathogenic MLH1 P40692 R273Y 273 R Y 0.956 Pathogenic MLH1 P40692 K274A 274 K A 0.108 Neutral MLH1 P40692 K274C 274 K C 0.428 Neutral MLH1 P40692 K274D 274 K D 0.224 Neutral MLH1 P40692 K274E 274 K E 0.696 Pathogenic MLH1 P40692 K274F 274 K F 0.928 Pathogenic MLH1 P40692 K274G 274 K G 0.544 Pathogenic MLH1 P40692 K274H 274 K H 0.714 Pathogenic MLH1 P40692 K274I 274 K I 0.724 Pathogenic MLH1 P40692 K274L 274 K L 0.964 Pathogenic MLH1 P40692 K274M 274 K M 0.876 Pathogenic MLH1 P40692 K274N 274 K N 0.254 Neutral MLH1 P40692 K274P 274 K P 0.892 Pathogenic MLH1 P40692 K274Q 274 K Q 0.152 Neutral MLH1 P40692 K274R 274 K R 0.104 Neutral MLH1 P40692 K274S 274 K S 0.138 Neutral MLH1 P40692 K274T 274 K T 0.12 Neutral MLH1 P40692 K274V 274 K V 0.514 Pathogenic MLH1 P40692 K274W 274 K W 0.98 Pathogenic MLH1 P40692 K274Y 274 K Y 0.968 Pathogenic MLH1 P40692 A275C 275 A C 0.364 Neutral MLH1 P40692 A275D 275 A D 0.784 Pathogenic MLH1 P40692 A275E 275 A E 0.734 Pathogenic MLH1 P40692 A275F 275 A F 0.948 Pathogenic MLH1 P40692 A275G 275 A G 0.108 Neutral MLH1 P40692 A275H 275 A H 0.844 Pathogenic MLH1 P40692 A275I 275 A I 0.906 Pathogenic MLH1 P40692 A275K 275 A K 0.85 Pathogenic MLH1 P40692 A275L 275 A L 0.946 Pathogenic MLH1 P40692 A275M 275 A M 0.612 Pathogenic MLH1 P40692 A275N 275 A N 0.59 Pathogenic MLH1 P40692 A275P 275 A P 0.918 Pathogenic MLH1 P40692 A275Q 275 A Q 0.66 Pathogenic MLH1 P40692 A275R 275 A R 0.906 Pathogenic MLH1 P40692 A275S 275 A S 0.128 Neutral MLH1 P40692 A275T 275 A T 0.198 Neutral MLH1 P40692 A275V 275 A V 0.57 Pathogenic MLH1 P40692 A275W 275 A W 0.948 Pathogenic MLH1 P40692 A275Y 275 A Y 0.912 Pathogenic MLH1 P40692 I276A 276 I A 0.134 Neutral MLH1 P40692 I276C 276 I C 0.052 Neutral MLH1 P40692 I276D 276 I D 0.63 Pathogenic MLH1 P40692 I276E 276 I E 0.47 Neutral MLH1 P40692 I276F 276 I F 0.19 Neutral MLH1 P40692 I276G 276 I G 0.32 Neutral MLH1 P40692 I276H 276 I H 0.512 Pathogenic MLH1 P40692 I276K 276 I K 0.468 Neutral MLH1 P40692 I276L 276 I L 0.008 Neutral MLH1 P40692 I276M 276 I M 0.354 Neutral MLH1 P40692 I276N 276 I N 0.586 Pathogenic MLH1 P40692 I276P 276 I P 0.33 Neutral MLH1 P40692 I276Q 276 I Q 0.534 Pathogenic MLH1 P40692 I276R 276 I R 0.828 Pathogenic MLH1 P40692 I276S 276 I S 0.43 Neutral MLH1 P40692 I276T 276 I T 0.324 Neutral MLH1 P40692 I276V 276 I V 0.002 Neutral MLH1 P40692 I276W 276 I W 0.884 Pathogenic MLH1 P40692 I276Y 276 I Y 0.88 Pathogenic MLH1 P40692 E277A 277 E A 0.392 Neutral MLH1 P40692 E277C 277 E C 0.578 Pathogenic MLH1 P40692 E277D 277 E D 0.076 Neutral MLH1 P40692 E277F 277 E F 0.424 Neutral MLH1 P40692 E277G 277 E G 0.132 Neutral MLH1 P40692 E277H 277 E H 0.584 Pathogenic MLH1 P40692 E277I 277 E I 0.91 Pathogenic MLH1 P40692 E277K 277 E K 0.76 Pathogenic MLH1 P40692 E277L 277 E L 0.724 Pathogenic MLH1 P40692 E277M 277 E M 0.702 Pathogenic MLH1 P40692 E277N 277 E N 0.076 Neutral MLH1 P40692 E277P 277 E P 0.866 Pathogenic MLH1 P40692 E277Q 277 E Q 0.076 Neutral MLH1 P40692 E277R 277 E R 0.272 Neutral MLH1 P40692 E277S 277 E S 0.148 Neutral MLH1 P40692 E277T 277 E T 0.164 Neutral MLH1 P40692 E277V 277 E V 0.856 Pathogenic MLH1 P40692 E277W 277 E W 0.922 Pathogenic MLH1 P40692 E277Y 277 E Y 0.568 Pathogenic MLH1 P40692 T278A 278 T A 0.032 Neutral MLH1 P40692 T278C 278 T C 0.312 Neutral MLH1 P40692 T278D 278 T D 0.074 Neutral MLH1 P40692 T278E 278 T E 0.086 Neutral MLH1 P40692 T278F 278 T F 0.592 Pathogenic MLH1 P40692 T278G 278 T G 0.046 Neutral MLH1 P40692 T278H 278 T H 0.3 Neutral MLH1 P40692 T278I 278 T I 0.09 Neutral MLH1 P40692 T278K 278 T K 0.34 Neutral MLH1 P40692 T278L 278 T L 0.234 Neutral MLH1 P40692 T278M 278 T M 0.158 Neutral MLH1 P40692 T278N 278 T N 0.026 Neutral MLH1 P40692 T278P 278 T P 0.46 Neutral MLH1 P40692 T278Q 278 T Q 0.046 Neutral MLH1 P40692 T278R 278 T R 0.654 Pathogenic MLH1 P40692 T278S 278 T S 0.026 Neutral MLH1 P40692 T278V 278 T V 0.066 Neutral MLH1 P40692 T278W 278 T W 0.872 Pathogenic MLH1 P40692 T278Y 278 T Y 0.504 Pathogenic MLH1 P40692 V279A 279 V A 0.02 Neutral MLH1 P40692 V279C 279 V C 0.418 Neutral MLH1 P40692 V279D 279 V D 0.434 Neutral MLH1 P40692 V279E 279 V E 0.722 Pathogenic MLH1 P40692 V279F 279 V F 0.544 Pathogenic MLH1 P40692 V279G 279 V G 0.464 Neutral MLH1 P40692 V279H 279 V H 0.328 Neutral MLH1 P40692 V279I 279 V I 0.052 Neutral MLH1 P40692 V279K 279 V K 0.63 Pathogenic MLH1 P40692 V279L 279 V L 0.044 Neutral MLH1 P40692 V279M 279 V M 0.148 Neutral MLH1 P40692 V279N 279 V N 0.486 Neutral MLH1 P40692 V279P 279 V P 0.7 Pathogenic MLH1 P40692 V279Q 279 V Q 0.524 Pathogenic MLH1 P40692 V279R 279 V R 0.842 Pathogenic MLH1 P40692 V279S 279 V S 0.15 Neutral MLH1 P40692 V279T 279 V T 0.024 Neutral MLH1 P40692 V279W 279 V W 0.846 Pathogenic MLH1 P40692 V279Y 279 V Y 0.838 Pathogenic MLH1 P40692 P28A 28 P A 0.81 Pathogenic MLH1 P40692 P28C 28 P C 0.902 Pathogenic MLH1 P40692 P28D 28 P D 0.842 Pathogenic MLH1 P40692 P28E 28 P E 0.956 Pathogenic MLH1 P40692 P28F 28 P F 0.996 Pathogenic MLH1 P40692 P28G 28 P G 0.59 Pathogenic MLH1 P40692 P28H 28 P H 0.978 Pathogenic MLH1 P40692 P28I 28 P I 0.934 Pathogenic MLH1 P40692 P28K 28 P K 0.588 Pathogenic MLH1 P40692 P28L 28 P L 0.996 Pathogenic 5 MLH1 P40692 P28M 28 P M 0.954 Pathogenic MLH1 P40692 P28N 28 P N 0.71 Pathogenic MLH1 P40692 P28Q 28 P Q 0.842 Pathogenic MLH1 P40692 P28R 28 P R 0.98 Pathogenic MLH1 P40692 P28S 28 P S 0.346 Neutral MLH1 P40692 P28T 28 P T 0.708 Pathogenic MLH1 P40692 P28V 28 P V 0.84 Pathogenic MLH1 P40692 P28W 28 P W 0.94 Pathogenic MLH1 P40692 P28Y 28 P Y 0.94 Pathogenic MLH1 P40692 Y280A 280 Y A 0.228 Neutral MLH1 P40692 Y280C 280 Y C 0.656 Pathogenic MLH1 P40692 Y280D 280 Y D 0.802 Pathogenic MLH1 P40692 Y280E 280 Y E 0.708 Pathogenic MLH1 P40692 Y280F 280 Y F 0.17 Neutral MLH1 P40692 Y280G 280 Y G 0.472 Neutral MLH1 P40692 Y280H 280 Y H 0.588 Pathogenic MLH1 P40692 Y280I 280 Y I 0.794 Pathogenic MLH1 P40692 Y280K 280 Y K 0.42 Neutral MLH1 P40692 Y280L 280 Y L 0.27 Neutral MLH1 P40692 Y280M 280 Y M 0.32 Neutral MLH1 P40692 Y280N 280 Y N 0.286 Neutral MLH1 P40692 Y280P 280 Y P 0.788 Pathogenic MLH1 P40692 Y280Q 280 Y Q 0.336 Neutral MLH1 P40692 Y280R 280 Y R 0.45 Neutral MLH1 P40692 Y280S 280 Y S 0.288 Neutral MLH1 P40692 Y280T 280 Y T 0.344 Neutral MLH1 P40692 Y280V 280 Y V 0.758 Pathogenic MLH1 P40692 Y280W 280 Y W 0.902 Pathogenic MLH1 P40692 A281C 281 A C 0.742 Pathogenic MLH1 P40692 A281D 281 A D 0.902 Pathogenic MLH1 P40692 A281E 281 A E 0.706 Pathogenic MLH1 P40692 A281F 281 A F 0.968 Pathogenic MLH1 P40692 A281G 281 A G 0.032 Neutral MLH1 P40692 A281H 281 A H 0.698 Pathogenic MLH1 P40692 A281I 281 A I 0.934 Pathogenic MLH1 P40692 A281K 281 A K 0.914 Pathogenic MLH1 P40692 A281L 281 A L 0.916 Pathogenic MLH1 P40692 A281M 281 A M 0.836 Pathogenic MLH1 P40692 A281N 281 A N 0.6 Pathogenic MLH1 P40692 A281P 281 A P 0.28 Neutral MLH1 P40692 A281Q 281 A Q 0.508 Pathogenic MLH1 P40692 A281R 281 A R 0.928 Pathogenic MLH1 P40692 A281S 281 A S 0.018 Neutral MLH1 P40692 A281T 281 A T 0.044 Neutral MLH1 P40692 A281V 281 A V 0.248 Neutral 1 MLH1 P40692 A281W 281 A W 0.956 Pathogenic MLH1 P40692 A281Y 281 A Y 0.942 Pathogenic MLH1 P40692 A282C 282 A C 0.662 Pathogenic MLH1 P40692 A282D 282 A D 0.864 Pathogenic MLH1 P40692 A282E 282 A E 0.808 Pathogenic MLH1 P40692 A282F 282 A F 0.516 Pathogenic MLH1 P40692 A282G 282 A G 0.014 Neutral 2 MLH1 P40692 A282H 282 A H 0.654 Pathogenic MLH1 P40692 A282I 282 A I 0.566 Pathogenic MLH1 P40692 A282K 282 A K 0.556 Pathogenic MLH1 P40692 A282L 282 A L 0.54 Pathogenic MLH1 P40692 A282M 282 A M 0.534 Pathogenic MLH1 P40692 A282N 282 A N 0.538 Pathogenic MLH1 P40692 A282P 282 A P 0.236 Neutral MLH1 P40692 A282Q 282 A Q 0.506 Pathogenic MLH1 P40692 A282R 282 A R 0.866 Pathogenic MLH1 P40692 A282S 282 A S 0.012 Neutral MLH1 P40692 A282T 282 A T 0.038 Neutral MLH1 P40692 A282V 282 A V 0.092 Neutral MLH1 P40692 A282W 282 A W 0.916 Pathogenic MLH1 P40692 A282Y 282 A Y 0.74 Pathogenic MLH1 P40692 Y283A 283 Y A 0.204 Neutral MLH1 P40692 Y283C 283 Y C 0.348 Neutral MLH1 P40692 Y283D 283 Y D 0.436 Neutral MLH1 P40692 Y283E 283 Y E 0.572 Pathogenic MLH1 P40692 Y283F 283 Y F 0.026 Neutral MLH1 P40692 Y283G 283 Y G 0.246 Neutral MLH1 P40692 Y283H 283 Y H 0.104 Neutral MLH1 P40692 Y283I 283 Y I 0.074 Neutral MLH1 P40692 Y283K 283 Y K 0.57 Pathogenic MLH1 P40692 Y283L 283 Y L 0.052 Neutral MLH1 P40692 Y283M 283 Y M 0.348 Neutral MLH1 P40692 Y283N 283 Y N 0.304 Neutral MLH1 P40692 Y283P 283 Y P 0.212 Neutral MLH1 P40692 Y283Q 283 Y Q 0.374 Neutral MLH1 P40692 Y283R 283 Y R 0.61 Pathogenic MLH1 P40692 Y283S 283 Y S 0.276 Neutral MLH1 P40692 Y283T 283 Y T 0.142 Neutral MLH1 P40692 Y283V 283 Y V 0.148 Neutral MLH1 P40692 Y283W 283 Y W 0.556 Pathogenic MLH1 P40692 L284A 284 L A 0.288 Neutral MLH1 P40692 L284C 284 L C 0.816 Pathogenic MLH1 P40692 L284D 284 L D 0.896 Pathogenic MLH1 P40692 L284E 284 L E 0.876 Pathogenic MLH1 P40692 L284F 284 L F 0.642 Pathogenic MLH1 P40692 L284G 284 L G 0.814 Pathogenic MLH1 P40692 L284H 284 L H 0.906 Pathogenic MLH1 P40692 L284I 284 L I 0.296 Neutral MLH1 P40692 L284K 284 L K 0.206 Neutral MLH1 P40692 L284M 284 L M 0.198 Neutral MLH1 P40692 L284N 284 L N 0.268 Neutral MLH1 P40692 L284P 284 L P 0.992 Pathogenic MLH1 P40692 L284Q 284 L Q 0.734 Pathogenic MLH1 P40692 L284R 284 L R 0.984 Pathogenic MLH1 P40692 L284S 284 L S 0.316 Neutral MLH1 P40692 L284T 284 L T 0.606 Pathogenic MLH1 P40692 L284V 284 L V 0.532 Pathogenic MLH1 P40692 L284W 284 L W 0.928 Pathogenic MLH1 P40692 L284Y 284 L Y 0.894 Pathogenic MLH1 P40692 P285A 285 P A 0.17 Neutral MLH1 P40692 P285C 285 P C 0.908 Pathogenic MLH1 P40692 P285D 285 P D 0.856 Pathogenic MLH1 P40692 P285E 285 P E 0.582 Pathogenic MLH1 P40692 P285F 285 P F 0.994 Pathogenic MLH1 P40692 P285G 285 P G 0.652 Pathogenic MLH1 P40692 P285H 285 P H 0.974 Pathogenic MLH1 P40692 P285I 285 P I 0.93 Pathogenic MLH1 P40692 P285K 285 P K 0.946 Pathogenic MLH1 P40692 P285L 285 P L 0.682 Pathogenic MLH1 P40692 P285M 285 P M 0.952 Pathogenic MLH1 P40692 P285N 285 P N 0.75 Pathogenic MLH1 P40692 P285Q 285 P Q 0.842 Pathogenic MLH1 P40692 P285R 285 P R 0.976 Pathogenic MLH1 P40692 P285S 285 P S 0.088 Neutral MLH1 P40692 P285T 285 P T 0.198 Neutral MLH1 P40692 P285V 285 P V 0.846 Pathogenic MLH1 P40692 P285W 285 P W 0.824 Pathogenic MLH1 P40692 P285Y 285 P Y 0.926 Pathogenic MLH1 P40692 K286A 286 K A 0.692 Pathogenic MLH1 P40692 K286C 286 K C 0.576 Pathogenic MLH1 P40692 K286D 286 K D 0.76 Pathogenic MLH1 P40692 K286E 286 K E 0.87 Pathogenic MLH1 P40692 K286F 286 K F 0.97 Pathogenic MLH1 P40692 K286G 286 K G 0.54 Pathogenic MLH1 P40692 K286H 286 K H 0.87 Pathogenic MLH1 P40692 K286I 286 K I 0.728 Pathogenic MLH1 P40692 K286L 286 K L 0.688 Pathogenic MLH1 P40692 K286M 286 K M 0.914 Pathogenic MLH1 P40692 K286N 286 K N 0.356 Neutral MLH1 P40692 K286P 286 K P 0.922 Pathogenic MLH1 P40692 K286Q 286 K Q 0.856 Pathogenic MLH1 P40692 K286R 286 K R 0.226 Neutral MLH1 P40692 K286S 286 K S 0.316 Neutral MLH1 P40692 K286T 286 K T 0.264 Neutral MLH1 P40692 K286V 286 K V 0.886 Pathogenic MLH1 P40692 K286W 286 K W 0.99 Pathogenic MLH1 P40692 K286Y 286 K Y 0.982 Pathogenic MLH1 P40692 N287A 287 N A 0.072 Neutral MLH1 P40692 N287C 287 N C 0.61 Pathogenic MLH1 P40692 N287D 287 N D 0.584 Pathogenic MLH1 P40692 N287E 287 N E 0.312 Neutral MLH1 P40692 N287F 287 N F 0.92 Pathogenic MLH1 P40692 N287G 287 N G 0.242 Neutral MLH1 P40692 N287H 287 N H 0.076 Neutral MLH1 P40692 N287I 287 N I 0.896 Pathogenic MLH1 P40692 N287K 287 N K 0.094 Neutral MLH1 P40692 N287L 287 N L 0.894 Pathogenic MLH1 P40692 N287M 287 N M 0.864 Pathogenic MLH1 P40692 N287P 287 N P 0.778 Pathogenic MLH1 P40692 N287Q 287 N Q 0.062 Neutral MLH1 P40692 N287R 287 N R 0.55 Pathogenic MLH1 P40692 N287S 287 N S 0.034 Neutral MLH1 P40692 N287T 287 N T 0.582 Pathogenic MLH1 P40692 N287V 287 N V 0.81 Pathogenic MLH1 P40692 N287W 287 N W 0.956 Pathogenic MLH1 P40692 N287Y 287 N Y 0.948 Pathogenic MLH1 P40692 T288A 288 T A 0.08 Neutral MLH1 P40692 T288C 288 T C 0.316 Neutral MLH1 P40692 T288D 288 T D 0.352 Neutral MLH1 P40692 T288E 288 T E 0.572 Pathogenic MLH1 P40692 T288F 288 T F 0.64 Pathogenic MLH1 P40692 T288G 288 T G 0.052 Neutral MLH1 P40692 T288H 288 T H 0.46 Neutral MLH1 P40692 T288I 288 T I 0.52 Pathogenic MLH1 P40692 T288K 288 T K 0.128 Neutral MLH1 P40692 T288L 288 T L 0.52 Pathogenic MLH1 P40692 T288M 288 T M 0.176 Neutral MLH1 P40692 T288N 288 T N 0.026 Neutral MLH1 P40692 T288P 288 T P 0.61 Pathogenic MLH1 P40692 T288Q 288 T Q 0.038 Neutral MLH1 P40692 T288R 288 T R 0.674 Pathogenic MLH1 P40692 T288S 288 T S 0.028 Neutral MLH1 P40692 T288V 288 T V 0.714 Pathogenic MLH1 P40692 T288W 288 T W 0.924 Pathogenic MLH1 P40692 T288Y 288 T Y 0.918 Pathogenic MLH1 P40692 H289A 289 H A 0.146 Neutral MLH1 P40692 H289C 289 H C 0.074 Neutral MLH1 P40692 H289D 289 H D 0.09 Neutral MLH1 P40692 H289E 289 H E 0.112 Neutral MLH1 P40692 H289F 289 H F 0.126 Neutral MLH1 P40692 H289G 289 H G 0.254 Neutral MLH1 P40692 H289I 289 H I 0.622 Pathogenic MLH1 P40692 H289K 289 H K 0.032 Neutral MLH1 P40692 H289L 289 H L 0.65 Pathogenic MLH1 P40692 H289M 289 H M 0.55 Pathogenic MLH1 P40692 H289N 289 H N 0.04 Neutral MLH1 P40692 H289P 289 H P 0.846 Pathogenic MLH1 P40692 H289Q 289 H Q 0.1 Neutral MLH1 P40692 H289R 289 H R 0.018 Neutral MLH1 P40692 H289S 289 H S 0.028 Neutral MLH1 P40692 H289T 289 H T 0.32 Neutral MLH1 P40692 H289V 289 H V 0.444 Neutral MLH1 P40692 H289W 289 H W 0.91 Pathogenic MLH1 P40692 H289Y 289 H Y 0.13 Neutral MLH1 P40692 A29C 29 A C 0.748 Pathogenic MLH1 P40692 A29D 29 A D 0.858 Pathogenic MLH1 P40692 A29E 29 A E 0.664 Pathogenic MLH1 P40692 A29F 29 A F 0.906 Pathogenic MLH1 P40692 A29G 29 A G 0.512 Pathogenic MLH1 P40692 A29H 29 A H 0.872 Pathogenic MLH1 P40692 A29I 29 A I 0.938 Pathogenic MLH1 P40692 A29K 29 A K 0.916 Pathogenic MLH1 P40692 A29L 29 A L 0.958 Pathogenic MLH1 P40692 A29M 29 A M 0.574 Pathogenic MLH1 P40692 A29N 29 A N 0.77 Pathogenic MLH1 P40692 A29P 29 A P 0.826 Pathogenic MLH1 P40692 A29Q 29 A Q 0.79 Pathogenic MLH1 P40692 A29R 29 A R 0.922 Pathogenic MLH1 P40692 A29S 29 A S 0.04 Neutral MLH1 P40692 A29T 29 A T 0.188 Neutral MLH1 P40692 A29V 29 A V 0.17 Neutral MLH1 P40692 A29W 29 A W 0.962 Pathogenic MLH1 P40692 A29Y 29 A Y 0.934 Pathogenic MLH1 P40692 P290A 290 P A 0.184 Neutral MLH1 P40692 P290C 290 P C 0.52 Pathogenic MLH1 P40692 P290D 290 P D 0.858 Pathogenic MLH1 P40692 P290E 290 P E 0.584 Pathogenic MLH1 P40692 P290F 290 P F 0.996 Pathogenic MLH1 P40692 P290G 290 P G 0.298 Neutral MLH1 P40692 P290H 290 P H 0.698 Pathogenic MLH1 P40692 P290I 290 P I 0.936 Pathogenic MLH1 P40692 P290K 290 P K 0.95 Pathogenic MLH1 P40692 P290L 290 P L 0.996 Pathogenic MLH1 P40692 P290M 290 P M 0.956 Pathogenic MLH1 P40692 P290N 290 P N 0.272 Neutral MLH1 P40692 P290Q 290 P Q 0.546 Pathogenic MLH1 P40692 P290R 290 P R 0.98 Pathogenic MLH1 P40692 P290S 290 P S 0.084 Neutral MLH1 P40692 P290T 290 P T 0.146 Neutral MLH1 P40692 P290V 290 P V 0.482 Neutral MLH1 P40692 P290W 290 P W 0.934 Pathogenic MLH1 P40692 P290Y 290 P Y 0.932 Pathogenic MLH1 P40692 F291A 291 F A 0.226 Neutral MLH1 P40692 F291C 291 F C 0.572 Pathogenic MLH1 P40692 F291D 291 F D 0.432 Neutral MLH1 P40692 F291E 291 F E 0.26 Neutral MLH1 P40692 F291G 291 F G 0.47 Neutral MLH1 P40692 F291H 291 F H 0.624 Pathogenic MLH1 P40692 F291I 291 F I 0.554 Pathogenic MLH1 P40692 F291K 291 F K 0.19 Neutral MLH1 P40692 F291L 291 F L 0.536 Pathogenic MLH1 P40692 F291M 291 F M 0.652 Pathogenic MLH1 P40692 F291N 291 F N 0.674 Pathogenic MLH1 P40692 F291P 291 F P 0.93 Pathogenic MLH1 P40692 F291Q 291 F Q 0.704 Pathogenic MLH1 P40692 F291R 291 F R 0.894 Pathogenic MLH1 P40692 F291S 291 F S 0.18 Neutral MLH1 P40692 F291T 291 F T 0.216 Neutral MLH1 P40692 F291V 291 F V 0.83 Pathogenic MLH1 P40692 F291W 291 F W 0.626 Pathogenic MLH1 P40692 F291Y 291 F Y 0.298 Neutral MLH1 P40692 L292A 292 L A 0.054 Neutral MLH1 P40692 L292C 292 L C 0.038 Neutral MLH1 P40692 L292D 292 L D 0.548 Pathogenic MLH1 P40692 L292E 292 L E 0.454 Neutral MLH1 P40692 L292F 292 L F 0.304 Neutral MLH1 P40692 L292G 292 L G 0.536 Pathogenic MLH1 P40692 L292H 292 L H 0.352 Neutral MLH1 P40692 L292I 292 L I 0.052 Neutral MLH1 P40692 L292K 292 L K 0.44 Neutral MLH1 P40692 L292M 292 L M 0.032 Neutral MLH1 P40692 L292N 292 L N 0.26 Neutral MLH1 P40692 L292P 292 L P 0.834 Pathogenic MLH1 P40692 L292Q 292 L Q 0.306 Neutral MLH1 P40692 L292R 292 L R 0.86 Pathogenic MLH1 P40692 L292S 292 L S 0.462 Neutral MLH1 P40692 L292T 292 L T 0.048 Neutral MLH1 P40692 L292V 292 L V 0.012 Neutral MLH1 P40692 L292W 292 L W 0.868 Pathogenic MLH1 P40692 L292Y 292 L Y 0.672 Pathogenic MLH1 P40692 Y293A 293 Y A 0.422 Neutral MLH1 P40692 Y293C 293 Y C 0.656 Pathogenic MLH1 P40692 Y293D 293 Y D 0.284 Neutral MLH1 P40692 Y293E 293 Y E 0.416 Neutral MLH1 P40692 Y293F 293 Y F 0.186 Neutral MLH1 P40692 Y293G 293 Y G 0.472 Neutral MLH1 P40692 Y293H 293 Y H 0.588 Pathogenic MLH1 P40692 Y293I 293 Y I 0.342 Neutral MLH1 P40692 Y293K 293 Y K 0.418 Neutral MLH1 P40692 Y293L 293 Y L 0.27 Neutral MLH1 P40692 Y293M 293 Y M 0.32 Neutral MLH1 P40692 Y293N 293 Y N 0.238 Neutral MLH1 P40692 Y293P 293 Y P 0.786 Pathogenic MLH1 P40692 Y293Q 293 Y Q 0.61 Pathogenic MLH1 P40692 Y293R 293 Y R 0.728 Pathogenic MLH1 P40692 Y293S 293 Y S 0.214 Neutral MLH1 P40692 Y293T 293 Y T 0.652 Pathogenic MLH1 P40692 Y293V 293 Y V 0.744 Pathogenic MLH1 P40692 Y293W 293 Y W 0.902 Pathogenic MLH1 P40692 L294A 294 L A 0.164 Neutral MLH1 P40692 L294C 294 L C 0.166 Neutral MLH1 P40692 L294D 294 L D 0.192 Neutral MLH1 P40692 L294E 294 L E 0.504 Pathogenic MLH1 P40692 L294F 294 L F 0.458 Neutral MLH1 P40692 L294G 294 L G 0.798 Pathogenic MLH1 P40692 L294H 294 L H 0.312 Neutral MLH1 P40692 L294I 294 L I 0.124 Neutral MLH1 P40692 L294K 294 L K 0.668 Pathogenic MLH1 P40692 L294M 294 L M 0.152 Neutral MLH1 P40692 L294N 294 L N 0.484 Neutral MLH1 P40692 L294P 294 L P 0.948 Pathogenic MLH1 P40692 L294Q 294 L Q 0.588 Pathogenic MLH1 P40692 L294R 294 L R 0.988 Pathogenic MLH1 P40692 L294S 294 L S 0.34 Neutral MLH1 P40692 L294T 294 L T 0.128 Neutral MLH1 P40692 L294V 294 L V 0.104 Neutral MLH1 P40692 L294W 294 L W 0.84 Pathogenic MLH1 P40692 L294Y 294 L Y 0.8 Pathogenic MLH1 P40692 S295A 295 S A 0.236 Neutral MLH1 P40692 S295C 295 S C 0.552 Pathogenic MLH1 P40692 S295D 295 S D 0.326 Neutral MLH1 P40692 S295E 295 S E 0.93 Pathogenic MLH1 P40692 S295F 295 S F 0.982 Pathogenic MLH1 P40692 S295G 295 S G 0.164 Neutral 1 MLH1 P40692 S295H 295 S H 0.726 Pathogenic MLH1 P40692 S295I 295 S I 0.884 Pathogenic MLH1 P40692 S295K 295 S K 0.7 Pathogenic MLH1 P40692 S295L 295 S L 0.92 Pathogenic MLH1 P40692 S295M 295 S M 0.998 Pathogenic MLH1 P40692 S295N 295 S N 0.248 Neutral MLH1 P40692 S295P 295 S P 0.95 Pathogenic MLH1 P40692 S295Q 295 S Q 0.622 Pathogenic MLH1 P40692 S295R 295 S R 0.648 Pathogenic MLH1 P40692 S295T 295 S T 0.78 Pathogenic 4 MLH1 P40692 S295V 295 S V 0.542 Pathogenic MLH1 P40692 S295W 295 S W 0.982 Pathogenic MLH1 P40692 S295Y 295 S Y 0.924 Pathogenic MLH1 P40692 L296A 296 L A 0.566 Pathogenic MLH1 P40692 L296C 296 L C 0.282 Neutral MLH1 P40692 L296D 296 L D 0.894 Pathogenic MLH1 P40692 L296E 296 L E 0.262 Neutral MLH1 P40692 L296F 296 L F 0.976 Pathogenic MLH1 P40692 L296G 296 L G 0.46 Neutral MLH1 P40692 L296H 296 L H 0.814 Pathogenic MLH1 P40692 L296I 296 L I 0.16 Neutral MLH1 P40692 L296K 296 L K 0.746 Pathogenic MLH1 P40692 L296M 296 L M 0.214 Neutral MLH1 P40692 L296N 296 L N 0.478 Neutral MLH1 P40692 L296P 296 L P 0.69 Pathogenic MLH1 P40692 L296Q 296 L Q 0.168 Neutral MLH1 P40692 L296R 296 L R 0.988 Pathogenic MLH1 P40692 L296S 296 L S 0.338 Neutral MLH1 P40692 L296T 296 L T 0.184 Neutral MLH1 P40692 L296V 296 L V 0.098 Neutral MLH1 P40692 L296W 296 L W 0.94 Pathogenic MLH1 P40692 L296Y 296 L Y 0.902 Pathogenic MLH1 P40692 E297A 297 E A 0.526 Pathogenic MLH1 P40692 E297C 297 E C 0.494 Neutral MLH1 P40692 E297D 297 E D 0.038 Neutral MLH1 P40692 E297F 297 E F 0.882 Pathogenic MLH1 P40692 E297G 297 E G 0.17 Neutral MLH1 P40692 E297H 297 E H 0.168 Neutral MLH1 P40692 E297I 297 E I 0.268 Neutral MLH1 P40692 E297K 297 E K 0.088 Neutral MLH1 P40692 E297L 297 E L 0.138 Neutral MLH1 P40692 E297M 297 E M 0.32 Neutral MLH1 P40692 E297N 297 E N 0.044 Neutral MLH1 P40692 E297P 297 E P 0.89 Pathogenic MLH1 P40692 E297Q 297 E Q 0.034 Neutral MLH1 P40692 E297R 297 E R 0.598 Pathogenic MLH1 P40692 E297S 297 E S 0.08 Neutral MLH1 P40692 E297T 297 E T 0.076 Neutral MLH1 P40692 E297V 297 E V 0.106 Neutral MLH1 P40692 E297W 297 E W 0.972 Pathogenic MLH1 P40692 E297Y 297 E Y 0.922 Pathogenic MLH1 P40692 I298A 298 I A 0.482 Neutral MLH1 P40692 I298C 298 I C 0.632 Pathogenic MLH1 P40692 I298D 298 I D 0.774 Pathogenic MLH1 P40692 I298E 298 I E 0.166 Neutral MLH1 P40692 I298F 298 I F 0.422 Neutral MLH1 P40692 I298G 298 I G 0.818 Pathogenic MLH1 P40692 I298H 298 I H 0.85 Pathogenic MLH1 P40692 I298K 298 I K 0.242 Neutral MLH1 P40692 I298L 298 I L 0.082 Neutral MLH1 P40692 I298M 298 I M 0.158 Neutral MLH1 P40692 I298N 298 I N 0.8 Pathogenic MLH1 P40692 I298P 298 I P 0.498 Neutral MLH1 P40692 I298Q 298 I Q 0.264 Neutral MLH1 P40692 I298R 298 I R 0.884 Pathogenic MLH1 P40692 I298S 298 I S 0.21 Neutral MLH1 P40692 I298T 298 I T 0.278 Neutral MLH1 P40692 I298V 298 I V 0.126 Neutral MLH1 P40692 I298W 298 I W 0.972 Pathogenic MLH1 P40692 I298Y 298 I Y 0.966 Pathogenic MLH1 P40692 S299A 299 S A 0.04 Neutral MLH1 P40692 S299C 299 S C 0.276 Neutral MLH1 P40692 S299D 299 S D 0.048 Neutral MLH1 P40692 S299E 299 S E 0.346 Neutral MLH1 P40692 S299F 299 S F 0.72 Pathogenic MLH1 P40692 S299G 299 S G 0.044 Neutral MLH1 P40692 S299H 299 S H 0.376 Neutral MLH1 P40692 S299I 299 S I 0.406 Neutral MLH1 P40692 S299K 299 S K 0.36 Neutral MLH1 P40692 S299L 299 S L 0.406 Neutral MLH1 P40692 S299M 299 S M 0.82 Pathogenic MLH1 P40692 S299N 299 S N 0.036 Neutral MLH1 P40692 S299P 299 S P 0.11 Neutral MLH1 P40692 S299Q 299 S Q 0.454 Neutral MLH1 P40692 S299R 299 S R 0.382 Neutral MLH1 P40692 S299T 299 S T 0.058 Neutral MLH1 P40692 S299V 299 S V 0.73 Pathogenic MLH1 P40692 S299W 299 S W 0.888 Pathogenic MLH1 P40692 S299Y 299 S Y 0.862 Pathogenic MLH1 P40692 F3A 3 F A 0.112 Neutral MLH1 P40692 F3C 3 F C 0.088 Neutral MLH1 P40692 F3D 3 F D 0.162 Neutral MLH1 P40692 F3E 3 F E 0.192 Neutral MLH1 P40692 F3G 3 F G 0.136 Neutral MLH1 P40692 F3H 3 F H 0.072 Neutral MLH1 P40692 F3I 3 F I 0.054 Neutral MLH1 P40692 F3K 3 F K 0.184 Neutral MLH1 P40692 F3L 3 F L 0.002 Neutral MLH1 P40692 F3M 3 F M 0.068 Neutral MLH1 P40692 F3N 3 F N 0.174 Neutral MLH1 P40692 F3P 3 F P 0.178 Neutral MLH1 P40692 F3Q 3 F Q 0.172 Neutral MLH1 P40692 F3R 3 F R 0.142 Neutral MLH1 P40692 F3S 3 F S 0.156 Neutral MLH1 P40692 F3T 3 F T 0.172 Neutral MLH1 P40692 F3V 3 F V 0.166 Neutral MLH1 P40692 F3W 3 F W 0.268 Neutral MLH1 P40692 F3Y 3 F Y 0.1 Neutral MLH1 P40692 N30A 30 N A 0.626 Pathogenic MLH1 P40692 N30C 30 N C 0.582 Pathogenic MLH1 P40692 N30D 30 N D 0.592 Pathogenic MLH1 P40692 N30E 30 N E 0.494 Neutral MLH1 P40692 N30F 30 N F 0.904 Pathogenic MLH1 P40692 N30G 30 N G 0.688 Pathogenic MLH1 P40692 N30H 30 N H 0.334 Neutral MLH1 P40692 N30I 30 N I 0.886 Pathogenic MLH1 P40692 N30K 30 N K 0.812 Pathogenic MLH1 P40692 N30L 30 N L 0.778 Pathogenic MLH1 P40692 N30M 30 N M 0.862 Pathogenic MLH1 P40692 N30P 30 N P 0.74 Pathogenic MLH1 P40692 N30Q 30 N Q 0.708 Pathogenic MLH1 P40692 N30R 30 N R 0.826 Pathogenic MLH1 P40692 N30S 30 N S 0.194 Neutral MLH1 P40692 N30T 30 N T 0.522 Pathogenic MLH1 P40692 N30V 30 N V 0.922 Pathogenic MLH1 P40692 N30W 30 N W 0.918 Pathogenic MLH1 P40692 N30Y 30 N Y 0.91 Pathogenic MLH1 P40692 P300A 300 P A 0.168 Neutral MLH1 P40692 P300C 300 P C 0.882 Pathogenic MLH1 P40692 P300D 300 P D 0.452 Neutral MLH1 P40692 P300E 300 P E 0.592 Pathogenic MLH1 P40692 P300F 300 P F 0.7 Pathogenic MLH1 P40692 P300G 300 P G 0.2 Neutral MLH1 P40692 P300H 300 P H 0.704 Pathogenic MLH1 P40692 P300I 300 P I 0.914 Pathogenic MLH1 P40692 P300K 300 P K 0.36 Neutral MLH1 P40692 P300L 300 P L 0.974 Pathogenic MLH1 P40692 P300M 300 P M 0.948 Pathogenic MLH1 P40692 P300N 300 P N 0.38 Neutral MLH1 P40692 P300Q 300 P Q 0.548 Pathogenic MLH1 P40692 P300R 300 P R 0.974 Pathogenic MLH1 P40692 P300S 300 P S 0.094 Neutral MLH1 P40692 P300T 300 P T 0.148 Neutral MLH1 P40692 P300V 300 P V 0.258 Neutral MLH1 P40692 P300W 300 P W 0.932 Pathogenic MLH1 P40692 P300Y 300 P Y 0.93 Pathogenic MLH1 P40692 Q301A 301 Q A 0.12 Neutral MLH1 P40692 Q301C 301 Q C 0.422 Neutral MLH1 P40692 Q301D 301 Q D 0.124 Neutral MLH1 P40692 Q301E 301 Q E 0.03 Neutral MLH1 P40692 Q301F 301 Q F 0.778 Pathogenic MLH1 P40692 Q301G 301 Q G 0.366 Neutral MLH1 P40692 Q301H 301 Q H 0.076 Neutral MLH1 P40692 Q301I 301 Q I 0.824 Pathogenic MLH1 P40692 Q301K 301 Q K 0.054 Neutral MLH1 P40692 Q301L 301 Q L 0.284 Neutral MLH1 P40692 Q301M 301 Q M 0.388 Neutral MLH1 P40692 Q301N 301 Q N 0.08 Neutral MLH1 P40692 Q301P 301 Q P 0.57 Pathogenic MLH1 P40692 Q301R 301 Q R 0.056 Neutral MLH1 P40692 Q301S 301 Q S 0.084 Neutral MLH1 P40692 Q301T 301 Q T 0.314 Neutral MLH1 P40692 Q301V 301 Q V 0.79 Pathogenic MLH1 P40692 Q301W 301 Q W 0.894 Pathogenic MLH1 P40692 Q301Y 301 Q Y 0.85 Pathogenic MLH1 P40692 N302A 302 N A 0.074 Neutral MLH1 P40692 N302C 302 N C 0.13 Neutral MLH1 P40692 N302D 302 N D 0.548 Pathogenic MLH1 P40692 N302E 302 N E 0.53 Pathogenic MLH1 P40692 N302F 302 N F 0.42 Neutral MLH1 P40692 N302G 302 N G 0.62 Pathogenic MLH1 P40692 N302H 302 N H 0.064 Neutral MLH1 P40692 N302I 302 N I 0.85 Pathogenic MLH1 P40692 N302K 302 N K 0.108 Neutral MLH1 P40692 N302L 302 N L 0.282 Neutral MLH1 P40692 N302M 302 N M 0.86 Pathogenic MLH1 P40692 N302P 302 N P 0.76 Pathogenic MLH1 P40692 N302Q 302 N Q 0.266 Neutral MLH1 P40692 N302R 302 N R 0.466 Neutral MLH1 P40692 N302S 302 N S 0.042 Neutral MLH1 P40692 N302T 302 N T 0.024 Neutral MLH1 P40692 N302V 302 N V 0.42 Neutral MLH1 P40692 N302W 302 N W 0.95 Pathogenic MLH1 P40692 N302Y 302 N Y 0.942 Pathogenic MLH1 P40692 V303A 303 V A 0.134 Neutral MLH1 P40692 V303C 303 V C 0.714 Pathogenic MLH1 P40692 V303D 303 V D 0.862 Pathogenic MLH1 P40692 V303E 303 V E 0.982 Pathogenic MLH1 P40692 V303F 303 V F 0.876 Pathogenic MLH1 P40692 V303G 303 V G 0.898 Pathogenic MLH1 P40692 V303H 303 V H 0.82 Pathogenic MLH1 P40692 V303I 303 V I 0.164 Neutral MLH1 P40692 V303K 303 V K 0.36 Neutral MLH1 P40692 V303L 303 V L 0.21 Neutral MLH1 P40692 V303M 303 V M 0.818 Pathogenic MLH1 P40692 V303N 303 V N 0.924 Pathogenic MLH1 P40692 V303P 303 V P 0.978 Pathogenic MLH1 P40692 V303Q 303 V Q 0.99 Pathogenic MLH1 P40692 V303R 303 V R 0.692 Pathogenic MLH1 P40692 V303S 303 V S 0.732 Pathogenic MLH1 P40692 V303T 303 V T 0.75 Pathogenic MLH1 P40692 V303W 303 V W 0.904 Pathogenic MLH1 P40692 V303Y 303 V Y 0.93 Pathogenic MLH1 P40692 D304A 304 D A 0.386 Neutral MLH1 P40692 D304C 304 D C 0.846 Pathogenic MLH1 P40692 D304E 304 D E 0.734 Pathogenic MLH1 P40692 D304F 304 D F 0.972 Pathogenic MLH1 P40692 D304G 304 D G 0.904 Pathogenic MLH1 P40692 D304H 304 D H 0.576 Pathogenic MLH1 P40692 D304I 304 D I 0.964 Pathogenic MLH1 P40692 D304K 304 D K 0.872 Pathogenic MLH1 P40692 D304L 304 D L 0.96 Pathogenic MLH1 P40692 D304M 304 D M 0.94 Pathogenic MLH1 P40692 D304N 304 D N 0.826 Pathogenic MLH1 P40692 D304P 304 D P 0.872 Pathogenic MLH1 P40692 D304Q 304 D Q 0.524 Pathogenic MLH1 P40692 D304R 304 D R 0.95 Pathogenic MLH1 P40692 D304S 304 D S 0.074 Neutral MLH1 P40692 D304T 304 D T 0.268 Neutral MLH1 P40692 D304V 304 D V 0.984 Pathogenic 4 MLH1 P40692 D304W 304 D W 0.976 Pathogenic MLH1 P40692 D304Y 304 D Y 0.966 Pathogenic MLH1 P40692 V305A 305 V A 0.158 Neutral MLH1 P40692 V305C 305 V C 0.802 Pathogenic MLH1 P40692 V305D 305 V D 0.856 Pathogenic MLH1 P40692 V305E 305 V E 0.96 Pathogenic MLH1 P40692 V305F 305 V F 0.932 Pathogenic MLH1 P40692 V305G 305 V G 0.486 Neutral MLH1 P40692 V305H 305 V H 0.9 Pathogenic MLH1 P40692 V305I 305 V I 0.28 Neutral MLH1 P40692 V305K 305 V K 0.98 Pathogenic MLH1 P40692 V305L 305 V L 0.948 Pathogenic MLH1 P40692 V305M 305 V M 0.91 Pathogenic MLH1 P40692 V305N 305 V N 0.916 Pathogenic MLH1 P40692 V305P 305 V P 0.354 Neutral MLH1 P40692 V305Q 305 V Q 0.966 Pathogenic MLH1 P40692 V305R 305 V R 0.678 Pathogenic MLH1 P40692 V305S 305 V S 0.808 Pathogenic MLH1 P40692 V305T 305 V T 0.88 Pathogenic MLH1 P40692 V305W 305 V W 0.956 Pathogenic MLH1 P40692 V305Y 305 V Y 0.572 Pathogenic MLH1 P40692 N306A 306 N A 0.784 Pathogenic MLH1 P40692 N306C 306 N C 0.72 Pathogenic MLH1 P40692 N306D 306 N D 0.656 Pathogenic MLH1 P40692 N306E 306 N E 0.534 Pathogenic MLH1 P40692 N306F 306 N F 0.946 Pathogenic MLH1 P40692 N306G 306 N G 0.686 Pathogenic MLH1 P40692 N306H 306 N H 0.822 Pathogenic MLH1 P40692 N306I 306 N I 0.93 Pathogenic MLH1 P40692 N306K 306 N K 0.548 Pathogenic MLH1 P40692 N306L 306 N L 0.936 Pathogenic MLH1 P40692 N306M 306 N M 0.94 Pathogenic MLH1 P40692 N306P 306 N P 0.828 Pathogenic MLH1 P40692 N306Q 306 N Q 0.748 Pathogenic MLH1 P40692 N306R 306 N R 0.636 Pathogenic MLH1 P40692 N306S 306 N S 0.144 Neutral MLH1 P40692 N306T 306 N T 0.334 Neutral MLH1 P40692 N306V 306 N V 0.97 Pathogenic MLH1 P40692 N306W 306 N W 0.96 Pathogenic MLH1 P40692 N306Y 306 N Y 0.956 Pathogenic MLH1 P40692 V307A 307 V A 0.484 Neutral MLH1 P40692 V307C 307 V C 0.802 Pathogenic MLH1 P40692 V307D 307 V D 0.858 Pathogenic MLH1 P40692 V307E 307 V E 0.962 Pathogenic MLH1 P40692 V307F 307 V F 0.698 Pathogenic MLH1 P40692 V307G 307 V G 0.912 Pathogenic MLH1 P40692 V307H 307 V H 0.898 Pathogenic MLH1 P40692 V307I 307 V I 0.242 Neutral MLH1 P40692 V307K 307 V K 0.986 Pathogenic MLH1 P40692 V307L 307 V L 0.422 Neutral MLH1 P40692 V307M 307 V M 0.486 Neutral MLH1 P40692 V307N 307 V N 0.92 Pathogenic MLH1 P40692 V307P 307 V P 0.986 Pathogenic MLH1 P40692 V307Q 307 V Q 0.97 Pathogenic MLH1 P40692 V307R 307 V R 0.68 Pathogenic MLH1 P40692 V307S 307 V S 0.804 Pathogenic MLH1 P40692 V307T 307 V T 0.878 Pathogenic MLH1 P40692 V307W 307 V W 0.954 Pathogenic MLH1 P40692 V307Y 307 V Y 0.974 Pathogenic MLH1 P40692 H308A 308 H A 0.7 Pathogenic MLH1 P40692 H308C 308 H C 0.67 Pathogenic MLH1 P40692 H308D 308 H D 0.596 Pathogenic MLH1 P40692 H308E 308 H E 0.328 Neutral MLH1 P40692 H308F 308 H F 0.862 Pathogenic MLH1 P40692 H308G 308 H G 0.504 Pathogenic MLH1 P40692 H308I 308 H I 0.864 Pathogenic MLH1 P40692 H308K 308 H K 0.608 Pathogenic MLH1 P40692 H308L 308 H L 0.672 Pathogenic MLH1 P40692 H308M 308 H M 0.566 Pathogenic MLH1 P40692 H308N 308 H N 0.166 Neutral MLH1 P40692 H308P 308 H P 0.97 Pathogenic MLH1 P40692 H308Q 308 H Q 0.378 Neutral MLH1 P40692 H308R 308 H R 0.886 Pathogenic MLH1 P40692 H308S 308 H S 0.306 Neutral MLH1 P40692 H308T 308 H T 0.476 Neutral MLH1 P40692 H308V 308 H V 0.65 Pathogenic MLH1 P40692 H308W 308 H W 0.934 Pathogenic MLH1 P40692 H308Y 308 H Y 0.882 Pathogenic MLH1 P40692 P309A 309 P A 0.794 Pathogenic MLH1 P40692 P309C 309 P C 0.878 Pathogenic MLH1 P40692 P309D 309 P D 0.474 Neutral MLH1 P40692 P309E 309 P E 0.586 Pathogenic MLH1 P40692 P309F 309 P F 0.992 Pathogenic MLH1 P40692 P309G 309 P G 0.67 Pathogenic MLH1 P40692 P309H 309 P H 0.962 Pathogenic MLH1 P40692 P309I 309 P I 0.908 Pathogenic MLH1 P40692 P309K 309 P K 0.578 Pathogenic MLH1 P40692 P309L 309 P L 0.966 Pathogenic MLH1 P40692 P309M 309 P M 0.938 Pathogenic MLH1 P40692 P309N 309 P N 0.258 Neutral MLH1 P40692 P309Q 309 P Q 0.846 Pathogenic MLH1 P40692 P309R 309 P R 0.968 Pathogenic MLH1 P40692 P309S 309 P S 0.26 Neutral MLH1 P40692 P309T 309 P T 0.684 Pathogenic MLH1 P40692 P309V 309 P V 0.8 Pathogenic MLH1 P40692 P309W 309 P W 0.924 Pathogenic MLH1 P40692 P309Y 309 P Y 0.76 Pathogenic MLH1 P40692 A31C 31 A C 0.954 Pathogenic MLH1 P40692 A31D 31 A D 0.946 Pathogenic MLH1 P40692 A31E 31 A E 0.962 Pathogenic MLH1 P40692 A31F 31 A F 0.986 Pathogenic MLH1 P40692 A31G 31 A G 0.73 Pathogenic MLH1 P40692 A31H 31 A H 0.93 Pathogenic MLH1 P40692 A31I 31 A I 0.958 Pathogenic MLH1 P40692 A31K 31 A K 0.866 Pathogenic MLH1 P40692 A31L 31 A L 0.992 Pathogenic MLH1 P40692 A31M 31 A M 0.898 Pathogenic MLH1 P40692 A31N 31 A N 0.864 Pathogenic MLH1 P40692 A31P 31 A P 0.958 Pathogenic MLH1 P40692 A31Q 31 A Q 0.88 Pathogenic MLH1 P40692 A31R 31 A R 0.968 Pathogenic MLH1 P40692 A31S 31 A S 0.204 Neutral MLH1 P40692 A31T 31 A T 0.856 Pathogenic MLH1 P40692 A31V 31 A V 0.858 Pathogenic MLH1 P40692 A31W 31 A W 0.988 Pathogenic MLH1 P40692 A31Y 31 A Y 0.962 Pathogenic MLH1 P40692 T310A 310 T A 0.706 Pathogenic MLH1 P40692 T310C 310 T C 0.938 Pathogenic MLH1 P40692 T310D 310 T D 0.948 Pathogenic MLH1 P40692 T310E 310 T E 0.642 Pathogenic MLH1 P40692 T310F 310 T F 0.618 Pathogenic MLH1 P40692 T310G 310 T G 0.74 Pathogenic MLH1 P40692 T310H 310 T H 0.918 Pathogenic MLH1 P40692 T310I 310 T I 0.636 Pathogenic MLH1 P40692 T310K 310 T K 0.43 Neutral MLH1 P40692 T310L 310 T L 0.95 Pathogenic MLH1 P40692 T310M 310 T M 0.98 Pathogenic MLH1 P40692 T310N 310 T N 0.234 Neutral MLH1 P40692 T310P 310 T P 0.642 Pathogenic MLH1 P40692 T310Q 310 T Q 0.412 Neutral MLH1 P40692 T310R 310 T R 0.722 Pathogenic MLH1 P40692 T310S 310 T S 0.334 Neutral MLH1 P40692 T310V 310 T V 0.856 Pathogenic MLH1 P40692 T310W 310 T W 0.974 Pathogenic MLH1 P40692 T310Y 310 T Y 0.974 Pathogenic MLH1 P40692 K311A 311 K A 0.282 Neutral MLH1 P40692 K311C 311 K C 0.566 Pathogenic MLH1 P40692 K311D 311 K D 0.362 Neutral MLH1 P40692 K311E 311 K E 0.404 Neutral MLH1 P40692 K311F 311 K F 0.944 Pathogenic MLH1 P40692 K311G 311 K G 0.528 Pathogenic MLH1 P40692 K311H 311 K H 0.858 Pathogenic MLH1 P40692 K311I 311 K I 0.982 Pathogenic MLH1 P40692 K311L 311 K L 0.974 Pathogenic MLH1 P40692 K311M 311 K M 0.844 Pathogenic MLH1 P40692 K311N 311 K N 0.772 Pathogenic MLH1 P40692 K311P 311 K P 0.908 Pathogenic MLH1 P40692 K311Q 311 K Q 0.398 Neutral MLH1 P40692 K311R 311 K R 0.244 Neutral MLH1 P40692 K311S 311 K S 0.182 Neutral MLH1 P40692 K311T 311 K T 0.262 Neutral MLH1 P40692 K311V 311 K V 0.842 Pathogenic MLH1 P40692 K311W 311 K W 0.98 Pathogenic MLH1 P40692 K311Y 311 K Y 0.966 Pathogenic MLH1 P40692 H312A 312 H A 0.192 Neutral MLH1 P40692 H312C 312 H C 0.492 Neutral MLH1 P40692 H312D 312 H D 0.462 Neutral MLH1 P40692 H312E 312 H E 0.632 Pathogenic MLH1 P40692 H312F 312 H F 0.728 Pathogenic MLH1 P40692 H312G 312 H G 0.486 Neutral MLH1 P40692 H312I 312 H I 0.64 Pathogenic MLH1 P40692 H312K 312 H K 0.188 Neutral MLH1 P40692 H312L 312 H L 0.75 Pathogenic MLH1 P40692 H312M 312 H M 0.666 Pathogenic MLH1 P40692 H312N 312 H N 0.172 Neutral MLH1 P40692 H312P 312 H P 0.932 Pathogenic MLH1 P40692 H312Q 312 H Q 0.108 Neutral MLH1 P40692 H312R 312 H R 0.13 Neutral MLH1 P40692 H312S 312 H S 0.13 Neutral MLH1 P40692 H312T 312 H T 0.61 Pathogenic MLH1 P40692 H312V 312 H V 0.374 Neutral MLH1 P40692 H312W 312 H W 0.954 Pathogenic MLH1 P40692 H312Y 312 H Y 0.794 Pathogenic MLH1 P40692 E313A 313 E A 0.792 Pathogenic MLH1 P40692 E313C 313 E C 0.734 Pathogenic MLH1 P40692 E313D 313 E D 0.348 Neutral MLH1 P40692 E313F 313 E F 0.942 Pathogenic MLH1 P40692 E313G 313 E G 0.336 Neutral MLH1 P40692 E313H 313 E H 0.532 Pathogenic MLH1 P40692 E313I 313 E I 0.788 Pathogenic MLH1 P40692 E313K 313 E K 0.87 Pathogenic MLH1 P40692 E313L 313 E L 0.954 Pathogenic MLH1 P40692 E313M 313 E M 0.884 Pathogenic MLH1 P40692 E313N 313 E N 0.266 Neutral MLH1 P40692 E313P 313 E P 0.446 Neutral MLH1 P40692 E313Q 313 E Q 0.274 Neutral MLH1 P40692 E313R 313 E R 0.914 Pathogenic MLH1 P40692 E313S 313 E S 0.868 Pathogenic MLH1 P40692 E313T 313 E T 0.354 Neutral MLH1 P40692 E313V 313 E V 0.654 Pathogenic MLH1 P40692 E313W 313 E W 0.97 Pathogenic MLH1 P40692 E313Y 313 E Y 0.946 Pathogenic MLH1 P40692 V314A 314 V A 0.524 Pathogenic MLH1 P40692 V314C 314 V C 0.81 Pathogenic MLH1 P40692 V314D 314 V D 0.87 Pathogenic MLH1 P40692 V314E 314 V E 0.966 Pathogenic MLH1 P40692 V314F 314 V F 0.932 Pathogenic MLH1 P40692 V314G 314 V G 0.93 Pathogenic MLH1 P40692 V314H 314 V H 0.914 Pathogenic MLH1 P40692 V314I 314 V I 0.414 Neutral MLH1 P40692 V314K 314 V K 0.984 Pathogenic MLH1 P40692 V314L 314 V L 0.672 Pathogenic MLH1 P40692 V314M 314 V M 0.918 Pathogenic MLH1 P40692 V314N 314 V N 0.926 Pathogenic MLH1 P40692 V314P 314 V P 0.99 Pathogenic MLH1 P40692 V314Q 314 V Q 0.972 Pathogenic MLH1 P40692 V314R 314 V R 0.956 Pathogenic MLH1 P40692 V314S 314 V S 0.812 Pathogenic MLH1 P40692 V314T 314 V T 0.392 Neutral MLH1 P40692 V314W 314 V W 0.956 Pathogenic MLH1 P40692 V314Y 314 V Y 0.976 Pathogenic MLH1 P40692 H315A 315 H A 0.196 Neutral MLH1 P40692 H315C 315 H C 0.476 Neutral MLH1 P40692 H315D 315 H D 0.462 Neutral MLH1 P40692 H315E 315 H E 0.618 Pathogenic MLH1 P40692 H315F 315 H F 0.724 Pathogenic MLH1 P40692 H315G 315 H G 0.228 Neutral MLH1 P40692 H315I 315 H I 0.814 Pathogenic MLH1 P40692 H315K 315 H K 0.188 Neutral MLH1 P40692 H315L 315 H L 0.738 Pathogenic MLH1 P40692 H315M 315 H M 0.648 Pathogenic MLH1 P40692 H315N 315 H N 0.078 Neutral MLH1 P40692 H315P 315 H P 0.93 Pathogenic MLH1 P40692 H315Q 315 H Q 0.096 Neutral MLH1 P40692 H315R 315 H R 0.116 Neutral MLH1 P40692 H315S 315 H S 0.14 Neutral MLH1 P40692 H315T 315 H T 0.322 Neutral MLH1 P40692 H315V 315 H V 0.538 Pathogenic MLH1 P40692 H315W 315 H W 0.94 Pathogenic MLH1 P40692 H315Y 315 H Y 0.788 Pathogenic MLH1 P40692 F316A 316 F A 0.496 Neutral MLH1 P40692 F316C 316 F C 0.714 Pathogenic MLH1 P40692 F316D 316 F D 0.79 Pathogenic MLH1 P40692 F316E 316 F E 0.836 Pathogenic MLH1 P40692 F316G 316 F G 0.5 Pathogenic MLH1 P40692 F316H 316 F H 0.748 Pathogenic MLH1 P40692 F316I 316 F I 0.198 Neutral MLH1 P40692 F316K 316 F K 0.816 Pathogenic MLH1 P40692 F316L 316 F L 0.166 Neutral MLH1 P40692 F316M 316 F M 0.768 Pathogenic MLH1 P40692 F316N 316 F N 0.736 Pathogenic MLH1 P40692 F316P 316 F P 0.944 Pathogenic MLH1 P40692 F316Q 316 F Q 0.748 Pathogenic MLH1 P40692 F316R 316 F R 0.884 Pathogenic MLH1 P40692 F316S 316 F S 0.848 Pathogenic MLH1 P40692 F316T 316 F T 0.544 Pathogenic MLH1 P40692 F316V 316 F V 0.694 Pathogenic MLH1 P40692 F316W 316 F W 0.832 Pathogenic MLH1 P40692 F316Y 316 F Y 0.504 Pathogenic MLH1 P40692 L317A 317 L A 0.706 Pathogenic MLH1 P40692 L317C 317 L C 0.81 Pathogenic MLH1 P40692 L317D 317 L D 0.88 Pathogenic MLH1 P40692 L317E 317 L E 0.292 Neutral MLH1 P40692 L317F 317 L F 0.838 Pathogenic MLH1 P40692 L317G 317 L G 0.844 Pathogenic MLH1 P40692 L317H 317 L H 0.442 Neutral MLH1 P40692 L317I 317 L I 0.368 Neutral MLH1 P40692 L317K 317 L K 0.696 Pathogenic MLH1 P40692 L317M 317 L M 0.228 Neutral MLH1 P40692 L317N 317 L N 0.778 Pathogenic MLH1 P40692 L317P 317 L P 0.97 Pathogenic MLH1 P40692 L317Q 317 L Q 0.408 Neutral MLH1 P40692 L317R 317 L R 0.698 Pathogenic MLH1 P40692 L317S 317 L S 0.128 Neutral MLH1 P40692 L317T 317 L T 0.096 Neutral MLH1 P40692 L317V 317 L V 0.362 Neutral MLH1 P40692 L317W 317 L W 0.838 Pathogenic MLH1 P40692 L317Y 317 L Y 0.86 Pathogenic MLH1 P40692 H318A 318 H A 0.54 Pathogenic MLH1 P40692 H318C 318 H C 0.478 Neutral MLH1 P40692 H318D 318 H D 0.086 Neutral MLH1 P40692 H318E 318 H E 0.192 Neutral MLH1 P40692 H318F 318 H F 0.718 Pathogenic MLH1 P40692 H318G 318 H G 0.494 Neutral MLH1 P40692 H318I 318 H I 0.798 Pathogenic MLH1 P40692 H318K 318 H K 0.346 Neutral MLH1 P40692 H318L 318 H L 0.728 Pathogenic MLH1 P40692 H318M 318 H M 0.632 Pathogenic MLH1 P40692 H318N 318 H N 0.072 Neutral MLH1 P40692 H318P 318 H P 0.366 Neutral MLH1 P40692 H318Q 318 H Q 0.658 Pathogenic MLH1 P40692 H318R 318 H R 0.678 Pathogenic MLH1 P40692 H318S 318 H S 0.132 Neutral MLH1 P40692 H318T 318 H T 0.596 Pathogenic MLH1 P40692 H318V 318 H V 0.522 Pathogenic MLH1 P40692 H318W 318 H W 0.932 Pathogenic MLH1 P40692 H318Y 318 H Y 0.362 Neutral MLH1 P40692 E319A 319 E A 0.764 Pathogenic MLH1 P40692 E319C 319 E C 0.716 Pathogenic MLH1 P40692 E319D 319 E D 0.28 Neutral MLH1 P40692 E319F 319 E F 0.972 Pathogenic MLH1 P40692 E319G 319 E G 0.38 Neutral MLH1 P40692 E319H 319 E H 0.876 Pathogenic MLH1 P40692 E319I 319 E I 0.396 Neutral MLH1 P40692 E319K 319 E K 0.982 Pathogenic MLH1 P40692 E319L 319 E L 0.98 Pathogenic MLH1 P40692 E319M 319 E M 0.926 Pathogenic MLH1 P40692 E319N 319 E N 0.708 Pathogenic MLH1 P40692 E319P 319 E P 0.936 Pathogenic MLH1 P40692 E319Q 319 E Q 0.132 Neutral MLH1 P40692 E319R 319 E R 0.9 Pathogenic MLH1 P40692 E319S 319 E S 0.9 Pathogenic MLH1 P40692 E319T 319 E T 0.886 Pathogenic MLH1 P40692 E319V 319 E V 0.308 Neutral MLH1 P40692 E319W 319 E W 0.986 Pathogenic MLH1 P40692 E319Y 319 E Y 0.966 Pathogenic MLH1 P40692 I32A 32 I A 0.284 Neutral MLH1 P40692 I32C 32 I C 0.436 Neutral MLH1 P40692 I32D 32 I D 0.634 Pathogenic MLH1 P40692 I32E 32 I E 0.618 Pathogenic MLH1 P40692 I32F 32 I F 0.702 Pathogenic MLH1 P40692 I32G 32 I G 0.602 Pathogenic MLH1 P40692 I32H 32 I H 0.512 Pathogenic MLH1 P40692 I32K 32 I K 0.63 Pathogenic MLH1 P40692 I32L 32 I L 0.14 Neutral MLH1 P40692 I32M 32 I M 0.406 Neutral MLH1 P40692 I32N 32 I N 0.676 Pathogenic MLH1 P40692 I32P 32 I P 0.762 Pathogenic MLH1 P40692 I32Q 32 I Q 0.65 Pathogenic MLH1 P40692 I32R 32 I R 0.748 Pathogenic MLH1 P40692 I32S 32 I S 0.426 Neutral MLH1 P40692 I32T 32 I T 0.33 Neutral MLH1 P40692 I32V 32 I V 0.002 Neutral MLH1 P40692 I32W 32 I W 0.884 Pathogenic MLH1 P40692 I32Y 32 I Y 0.882 Pathogenic MLH1 P40692 E320A 320 E A 0.308 Neutral MLH1 P40692 E320C 320 E C 0.596 Pathogenic MLH1 P40692 E320D 320 E D 0.122 Neutral MLH1 P40692 E320F 320 E F 0.898 Pathogenic MLH1 P40692 E320G 320 E G 0.096 Neutral MLH1 P40692 E320H 320 E H 0.246 Neutral MLH1 P40692 E320I 320 E I 0.944 Pathogenic MLH1 P40692 E320K 320 E K 0.69 Pathogenic MLH1 P40692 E320L 320 E L 0.3 Neutral MLH1 P40692 E320M 320 E M 0.756 Pathogenic MLH1 P40692 E320N 320 E N 0.082 Neutral MLH1 P40692 E320P 320 E P 0.89 Pathogenic MLH1 P40692 E320Q 320 E Q 0.12 Neutral MLH1 P40692 E320R 320 E R 0.484 Neutral MLH1 P40692 E320S 320 E S 0.194 Neutral MLH1 P40692 E320T 320 E T 0.166 Neutral MLH1 P40692 E320V 320 E V 0.882 Pathogenic MLH1 P40692 E320W 320 E W 0.962 Pathogenic MLH1 P40692 E320Y 320 E Y 0.932 Pathogenic MLH1 P40692 S321A 321 S A 0.04 Neutral MLH1 P40692 S321C 321 S C 0.454 Neutral MLH1 P40692 S321D 321 S D 0.074 Neutral MLH1 P40692 S321E 321 S E 0.466 Neutral MLH1 P40692 S321F 321 S F 0.684 Pathogenic MLH1 P40692 S321G 321 S G 0.35 Neutral MLH1 P40692 S321H 321 S H 0.674 Pathogenic MLH1 P40692 S321I 321 S I 0.592 Pathogenic MLH1 P40692 S321K 321 S K 0.448 Neutral MLH1 P40692 S321L 321 S L 0.168 Neutral MLH1 P40692 S321M 321 S M 0.896 Pathogenic MLH1 P40692 S321N 321 S N 0.048 Neutral MLH1 P40692 S321P 321 S P 0.602 Pathogenic MLH1 P40692 S321Q 321 S Q 0.472 Neutral MLH1 P40692 S321R 321 S R 0.684 Pathogenic MLH1 P40692 S321T 321 S T 0.064 Neutral MLH1 P40692 S321V 321 S V 0.118 Neutral MLH1 P40692 S321W 321 S W 0.952 Pathogenic MLH1 P40692 S321Y 321 S Y 0.932 Pathogenic MLH1 P40692 I322A 322 I A 0.534 Pathogenic MLH1 P40692 I322C 322 I C 0.65 Pathogenic MLH1 P40692 I322D 322 I D 0.74 Pathogenic MLH1 P40692 I322E 322 I E 0.746 Pathogenic MLH1 P40692 I322F 322 I F 0.958 Pathogenic MLH1 P40692 I322G 322 I G 0.804 Pathogenic MLH1 P40692 I322H 322 I H 0.892 Pathogenic MLH1 P40692 I322K 322 I K 0.842 Pathogenic MLH1 P40692 I322L 322 I L 0.082 Neutral MLH1 P40692 I322M 322 I M 0.178 Neutral MLH1 P40692 I322N 322 I N 0.764 Pathogenic MLH1 P40692 I322P 322 I P 0.928 Pathogenic MLH1 P40692 I322Q 322 I Q 0.778 Pathogenic MLH1 P40692 I322R 322 I R 0.864 Pathogenic MLH1 P40692 I322S 322 I S 0.646 Pathogenic MLH1 P40692 I322T 322 I T 0.258 Neutral MLH1 P40692 I322V 322 I V 0.108 Neutral MLH1 P40692 I322W 322 I W 0.99 Pathogenic MLH1 P40692 I322Y 322 I Y 0.978 Pathogenic MLH1 P40692 L323A 323 L A 0.128 Neutral MLH1 P40692 L323C 323 L C 0.166 Neutral MLH1 P40692 L323D 323 L D 0.656 Pathogenic MLH1 P40692 L323E 323 L E 0.61 Pathogenic MLH1 P40692 L323F 323 L F 0.276 Neutral MLH1 P40692 L323G 323 L G 0.454 Neutral MLH1 P40692 L323H 323 L H 0.408 Neutral MLH1 P40692 L323I 323 L I 0.082 Neutral MLH1 P40692 L323K 323 L K 0.416 Neutral MLH1 P40692 L323M 323 L M 0.14 Neutral MLH1 P40692 L323N 323 L N 0.604 Pathogenic MLH1 P40692 L323P 323 L P 0.954 Pathogenic MLH1 P40692 L323Q 323 L Q 0.034 Neutral MLH1 P40692 L323R 323 L R 0.568 Pathogenic MLH1 P40692 L323S 323 L S 0.392 Neutral MLH1 P40692 L323T 323 L T 0.04 Neutral MLH1 P40692 L323V 323 L V 0.002 Neutral MLH1 P40692 L323W 323 L W 0.806 Pathogenic MLH1 P40692 L323Y 323 L Y 0.846 Pathogenic MLH1 P40692 E324A 324 E A 0.248 Neutral MLH1 P40692 E324C 324 E C 0.604 Pathogenic MLH1 P40692 E324D 324 E D 0.086 Neutral MLH1 P40692 E324F 324 E F 0.91 Pathogenic MLH1 P40692 E324G 324 E G 0.12 Neutral MLH1 P40692 E324H 324 E H 0.612 Pathogenic MLH1 P40692 E324I 324 E I 0.952 Pathogenic MLH1 P40692 E324K 324 E K 0.284 Neutral MLH1 P40692 E324L 324 E L 0.48 Neutral MLH1 P40692 E324M 324 E M 0.772 Pathogenic MLH1 P40692 E324N 324 E N 0.09 Neutral MLH1 P40692 E324P 324 E P 0.894 Pathogenic MLH1 P40692 E324Q 324 E Q 0.068 Neutral MLH1 P40692 E324R 324 E R 0.324 Neutral MLH1 P40692 E324S 324 E S 0.144 Neutral MLH1 P40692 E324T 324 E T 0.178 Neutral MLH1 P40692 E324V 324 E V 0.884 Pathogenic MLH1 P40692 E324W 324 E W 0.968 Pathogenic MLH1 P40692 E324Y 324 E Y 0.94 Pathogenic MLH1 P40692 R325A 325 R A 0.086 Neutral MLH1 P40692 R325C 325 R C 0.046 Neutral MLH1 P40692 R325D 325 R D 0.05 Neutral MLH1 P40692 R325E 325 R E 0.046 Neutral MLH1 P40692 R325F 325 R F 0.764 Pathogenic MLH1 P40692 R325G 325 R G 0.24 Neutral MLH1 P40692 R325H 325 R H 0.03 Neutral MLH1 P40692 R325I 325 R I 0.156 Neutral MLH1 P40692 R325K 325 R K 0.026 Neutral MLH1 P40692 R325L 325 R L 0.084 Neutral MLH1 P40692 R325M 325 R M 0.598 Pathogenic MLH1 P40692 R325N 325 R N 0.028 Neutral MLH1 P40692 R325P 325 R P 0.726 Pathogenic MLH1 P40692 R325Q 325 R Q 0.032 Neutral 2 MLH1 P40692 R325S 325 R S 0.04 Neutral MLH1 P40692 R325T 325 R T 0.048 Neutral MLH1 P40692 R325V 325 R V 0.08 Neutral MLH1 P40692 R325W 325 R W 0.806 Pathogenic MLH1 P40692 R325Y 325 R Y 0.802 Pathogenic MLH1 P40692 V326A 326 V A 0.288 Neutral 1 MLH1 P40692 V326C 326 V C 0.696 Pathogenic MLH1 P40692 V326D 326 V D 0.836 Pathogenic MLH1 P40692 V326E 326 V E 0.952 Pathogenic MLH1 P40692 V326F 326 V F 0.56 Pathogenic MLH1 P40692 V326G 326 V G 0.864 Pathogenic MLH1 P40692 V326H 326 V H 0.818 Pathogenic MLH1 P40692 V326I 326 V I 0.166 Neutral MLH1 P40692 V326K 326 V K 0.974 Pathogenic MLH1 P40692 V326L 326 V L 0.266 Neutral MLH1 P40692 V326M 326 V M 0.256 Neutral MLH1 P40692 V326N 326 V N 0.896 Pathogenic MLH1 P40692 V326P 326 V P 0.964 Pathogenic MLH1 P40692 V326Q 326 V Q 0.96 Pathogenic MLH1 P40692 V326R 326 V R 0.938 Pathogenic MLH1 P40692 V326S 326 V S 0.696 Pathogenic MLH1 P40692 V326T 326 V T 0.752 Pathogenic MLH1 P40692 V326W 326 V W 0.916 Pathogenic MLH1 P40692 V326Y 326 V Y 0.942 Pathogenic MLH1 P40692 Q327A 327 Q A 0.122 Neutral MLH1 P40692 Q327C 327 Q C 0.038 Neutral MLH1 P40692 Q327D 327 Q D 0.482 Neutral MLH1 P40692 Q327E 327 Q E 0.028 Neutral MLH1 P40692 Q327F 327 Q F 0.818 Pathogenic MLH1 P40692 Q327G 327 Q G 0.34 Neutral MLH1 P40692 Q327H 327 Q H 0.786 Pathogenic MLH1 P40692 Q327I 327 Q I 0.862 Pathogenic MLH1 P40692 Q327K 327 Q K 0.058 Neutral MLH1 P40692 Q327L 327 Q L 0.786 Pathogenic MLH1 P40692 Q327M 327 Q M 0.722 Pathogenic MLH1 P40692 Q327N 327 Q N 0.374 Neutral MLH1 P40692 Q327P 327 Q P 0.844 Pathogenic MLH1 P40692 Q327R 327 Q R 0.084 Neutral MLH1 P40692 Q327S 327 Q S 0.096 Neutral MLH1 P40692 Q327T 327 Q T 0.042 Neutral MLH1 P40692 Q327V 327 Q V 0.096 Neutral MLH1 P40692 Q327W 327 Q W 0.93 Pathogenic MLH1 P40692 Q327Y 327 Q Y 0.892 Pathogenic MLH1 P40692 Q328A 328 Q A 0.106 Neutral MLH1 P40692 Q328C 328 Q C 0.374 Neutral MLH1 P40692 Q328D 328 Q D 0.022 Neutral MLH1 P40692 Q328E 328 Q E 0.03 Neutral MLH1 P40692 Q328F 328 Q F 0.31 Neutral MLH1 P40692 Q328G 328 Q G 0.106 Neutral MLH1 P40692 Q328H 328 Q H 0.412 Neutral MLH1 P40692 Q328I 328 Q I 0.328 Neutral MLH1 P40692 Q328K 328 Q K 0.046 Neutral MLH1 P40692 Q328L 328 Q L 0.166 Neutral MLH1 P40692 Q328M 328 Q M 0.702 Pathogenic MLH1 P40692 Q328N 328 Q N 0.06 Neutral MLH1 P40692 Q328P 328 Q P 0.792 Pathogenic MLH1 P40692 Q328R 328 Q R 0.032 Neutral MLH1 P40692 Q328S 328 Q S 0.084 Neutral MLH1 P40692 Q328T 328 Q T 0.028 Neutral MLH1 P40692 Q328V 328 Q V 0.77 Pathogenic MLH1 P40692 Q328W 328 Q W 0.874 Pathogenic MLH1 P40692 Q328Y 328 Q Y 0.822 Pathogenic MLH1 P40692 H329A 329 H A 0.098 Neutral MLH1 P40692 H329C 329 H C 0.024 Neutral MLH1 P40692 H329D 329 H D 0.02 Neutral MLH1 P40692 H329E 329 H E 0.012 Neutral MLH1 P40692 H329F 329 H F 0.408 Neutral MLH1 P40692 H329G 329 H G 0.146 Neutral MLH1 P40692 H329I 329 H I 0.39 Neutral MLH1 P40692 H329K 329 H K 0.022 Neutral MLH1 P40692 H329L 329 H L 0.058 Neutral MLH1 P40692 H329M 329 H M 0.59 Pathogenic MLH1 P40692 H329N 329 H N 0.02 Neutral MLH1 P40692 H329P 329 H P 0.864 Pathogenic 5 MLH1 P40692 H329Q 329 H Q 0.022 Neutral MLH1 P40692 H329R 329 H R 0.138 Neutral MLH1 P40692 H329S 329 H S 0.032 Neutral MLH1 P40692 H329T 329 H T 0.028 Neutral MLH1 P40692 H329V 329 H V 0.062 Neutral MLH1 P40692 H329W 329 H W 0.896 Pathogenic MLH1 P40692 H329Y 329 H Y 0.086 Neutral MLH1 P40692 K33A 33 K A 0.614 Pathogenic MLH1 P40692 K33C 33 K C 0.498 Neutral MLH1 P40692 K33D 33 K D 0.686 Pathogenic MLH1 P40692 K33E 33 K E 0.802 Pathogenic MLH1 P40692 K33F 33 K F 0.972 Pathogenic MLH1 P40692 K33G 33 K G 0.524 Pathogenic MLH1 P40692 K33H 33 K H 0.812 Pathogenic MLH1 P40692 K33I 33 K I 0.988 Pathogenic MLH1 P40692 K33L 33 K L 0.978 Pathogenic MLH1 P40692 K33M 33 K M 0.928 Pathogenic MLH1 P40692 K33N 33 K N 0.726 Pathogenic MLH1 P40692 K33P 33 K P 0.924 Pathogenic MLH1 P40692 K33Q 33 K Q 0.806 Pathogenic MLH1 P40692 K33R 33 K R 0.336 Neutral MLH1 P40692 K33S 33 K S 0.726 Pathogenic MLH1 P40692 K33T 33 K T 0.656 Pathogenic MLH1 P40692 K33V 33 K V 0.888 Pathogenic MLH1 P40692 K33W 33 K W 0.992 Pathogenic MLH1 P40692 K33Y 33 K Y 0.984 Pathogenic MLH1 P40692 I330A 330 I A 0.048 Neutral MLH1 P40692 I330C 330 I C 0.05 Neutral MLH1 P40692 I330D 330 I D 0.616 Pathogenic MLH1 P40692 I330E 330 I E 0.202 Neutral MLH1 P40692 I330F 330 I F 0.142 Neutral MLH1 P40692 I330G 330 I G 0.5 Pathogenic MLH1 P40692 I330H 330 I H 0.486 Neutral MLH1 P40692 I330K 330 I K 0.612 Pathogenic MLH1 P40692 I330L 330 I L 0.012 Neutral MLH1 P40692 I330M 330 I M 0.04 Neutral MLH1 P40692 I330N 330 I N 0.66 Pathogenic MLH1 P40692 I330P 330 I P 0.764 Pathogenic MLH1 P40692 I330Q 330 I Q 0.544 Pathogenic MLH1 P40692 I330R 330 I R 0.83 Pathogenic MLH1 P40692 I330S 330 I S 0.23 Neutral MLH1 P40692 I330T 330 I T 0.058 Neutral MLH1 P40692 I330V 330 I V 0.006 Neutral MLH1 P40692 I330W 330 I W 0.898 Pathogenic MLH1 P40692 I330Y 330 I Y 0.896 Pathogenic MLH1 P40692 E331A 331 E A 0.234 Neutral MLH1 P40692 E331C 331 E C 0.494 Neutral MLH1 P40692 E331D 331 E D 0.014 Neutral MLH1 P40692 E331F 331 E F 0.878 Pathogenic MLH1 P40692 E331G 331 E G 0.162 Neutral MLH1 P40692 E331H 331 E H 0.028 Neutral MLH1 P40692 E331I 331 E I 0.938 Pathogenic MLH1 P40692 E331K 331 E K 0.74 Pathogenic MLH1 P40692 E331L 331 E L 0.914 Pathogenic MLH1 P40692 E331M 331 E M 0.714 Pathogenic MLH1 P40692 E331N 331 E N 0.014 Neutral MLH1 P40692 E331P 331 E P 0.888 Pathogenic MLH1 P40692 E331Q 331 E Q 0.012 Neutral MLH1 P40692 E331R 331 E R 0.114 Neutral MLH1 P40692 E331S 331 E S 0.044 Neutral MLH1 P40692 E331T 331 E T 0.494 Neutral MLH1 P40692 E331V 331 E V 0.85 Pathogenic MLH1 P40692 E331W 331 E W 0.968 Pathogenic MLH1 P40692 E331Y 331 E Y 0.918 Pathogenic MLH1 P40692 S332A 332 S A 0.028 Neutral MLH1 P40692 S332C 332 S C 0.336 Neutral MLH1 P40692 S332D 332 S D 0.032 Neutral MLH1 P40692 S332E 332 S E 0.372 Neutral MLH1 P40692 S332F 332 S F 0.758 Pathogenic MLH1 P40692 S332G 332 S G 0.026 Neutral MLH1 P40692 S332H 332 S H 0.51 Pathogenic MLH1 P40692 S332I 332 S I 0.324 Neutral MLH1 P40692 S332K 332 S K 0.374 Neutral MLH1 P40692 S332L 332 S L 0.11 Neutral MLH1 P40692 S332M 332 S M 0.682 Pathogenic MLH1 P40692 S332N 332 S N 0.042 Neutral MLH1 P40692 S332P 332 S P 0.47 Neutral MLH1 P40692 S332Q 332 S Q 0.402 Neutral MLH1 P40692 S332R 332 S R 0.394 Neutral MLH1 P40692 S332T 332 S T 0.04 Neutral MLH1 P40692 S332V 332 S V 0.078 Neutral MLH1 P40692 S332W 332 S W 0.904 Pathogenic MLH1 P40692 S332Y 332 S Y 0.878 Pathogenic MLH1 P40692 K333A 333 K A 0.086 Neutral MLH1 P40692 K333C 333 K C 0.072 Neutral MLH1 P40692 K333D 333 K D 0.238 Neutral MLH1 P40692 K333E 333 K E 0.03 Neutral MLH1 P40692 K333F 333 K F 0.776 Pathogenic MLH1 P40692 K333G 333 K G 0.09 Neutral MLH1 P40692 K333H 333 K H 0.184 Neutral MLH1 P40692 K333I 333 K I 0.26 Neutral MLH1 P40692 K333L 333 K L 0.128 Neutral MLH1 P40692 K333M 333 K M 0.586 Pathogenic MLH1 P40692 K333N 333 K N 0.042 Neutral MLH1 P40692 K333P 333 K P 0.766 Pathogenic MLH1 P40692 K333Q 333 K Q 0.04 Neutral MLH1 P40692 K333R 333 K R 0.03 Neutral MLH1 P40692 K333S 333 K S 0.036 Neutral MLH1 P40692 K333T 333 K T 0.034 Neutral MLH1 P40692 K333V 333 K V 0.13 Neutral MLH1 P40692 K333W 333 K W 0.95 Pathogenic MLH1 P40692 K333Y 333 K Y 0.884 Pathogenic MLH1 P40692 L334A 334 L A 0.714 Pathogenic MLH1 P40692 L334C 334 L C 0.816 Pathogenic MLH1 P40692 L334D 334 L D 0.9 Pathogenic MLH1 P40692 L334E 334 L E 0.882 Pathogenic MLH1 P40692 L334F 334 L F 0.67 Pathogenic MLH1 P40692 L334G 334 L G 0.87 Pathogenic MLH1 P40692 L334H 334 L H 0.906 Pathogenic MLH1 P40692 L334I 334 L I 0.306 Neutral MLH1 P40692 L334K 334 L K 0.71 Pathogenic MLH1 P40692 L334M 334 L M 0.278 Neutral MLH1 P40692 L334N 334 L N 0.81 Pathogenic MLH1 P40692 L334P 334 L P 0.978 Pathogenic MLH1 P40692 L334Q 334 L Q 0.764 Pathogenic MLH1 P40692 L334R 334 L R 0.982 Pathogenic MLH1 P40692 L334S 334 L S 0.698 Pathogenic MLH1 P40692 L334T 334 L T 0.614 Pathogenic MLH1 P40692 L334V 334 L V 0.122 Neutral MLH1 P40692 L334W 334 L W 0.862 Pathogenic MLH1 P40692 L334Y 334 L Y 0.878 Pathogenic MLH1 P40692 L335A 335 L A 0.042 Neutral MLH1 P40692 L335C 335 L C 0.33 Neutral MLH1 P40692 L335D 335 L D 0.612 Pathogenic MLH1 P40692 L335E 335 L E 0.07 Neutral MLH1 P40692 L335F 335 L F 0.792 Pathogenic MLH1 P40692 L335G 335 L G 0.134 Neutral MLH1 P40692 L335H 335 L H 0.164 Neutral MLH1 P40692 L335I 335 L I 0.344 Neutral MLH1 P40692 L335K 335 L K 0.186 Neutral MLH1 P40692 L335M 335 L M 0.18 Neutral MLH1 P40692 L335N 335 L N 0.566 Pathogenic MLH1 P40692 L335P 335 L P 0.91 Pathogenic MLH1 P40692 L335Q 335 L Q 0.2 Neutral MLH1 P40692 L335R 335 L R 0.552 Pathogenic MLH1 P40692 L335S 335 L S 0.046 Neutral MLH1 P40692 L335T 335 L T 0.048 Neutral MLH1 P40692 L335V 335 L V 0.018 Neutral MLH1 P40692 L335W 335 L W 0.868 Pathogenic MLH1 P40692 L335Y 335 L Y 0.866 Pathogenic MLH1 P40692 G336A 336 G A 0.066 Neutral MLH1 P40692 G336C 336 G C 0.8 Pathogenic MLH1 P40692 G336D 336 G D 0.49 Neutral MLH1 P40692 G336E 336 G E 0.574 Pathogenic MLH1 P40692 G336F 336 G F 0.974 Pathogenic MLH1 P40692 G336H 336 G H 0.974 Pathogenic MLH1 P40692 G336I 336 G I 0.948 Pathogenic MLH1 P40692 G336K 336 G K 0.596 Pathogenic MLH1 P40692 G336L 336 G L 0.94 Pathogenic MLH1 P40692 G336M 336 G M 0.988 Pathogenic MLH1 P40692 G336N 336 G N 0.476 Neutral MLH1 P40692 G336P 336 G P 0.932 Pathogenic MLH1 P40692 G336Q 336 G Q 0.54 Pathogenic MLH1 P40692 G336R 336 G R 0.748 Pathogenic MLH1 P40692 G336S 336 G S 0.092 Neutral MLH1 P40692 G336T 336 G T 0.582 Pathogenic MLH1 P40692 G336V 336 G V 0.778 Pathogenic MLH1 P40692 G336W 336 G W 0.964 Pathogenic MLH1 P40692 G336Y 336 G Y 0.958 Pathogenic MLH1 P40692 S337A 337 S A 0.028 Neutral MLH1 P40692 S337C 337 S C 0.024 Neutral MLH1 P40692 S337D 337 S D 0.382 Neutral MLH1 P40692 S337E 337 S E 0.564 Pathogenic MLH1 P40692 S337F 337 S F 0.628 Pathogenic MLH1 P40692 S337G 337 S G 0.032 Neutral MLH1 P40692 S337H 337 S H 0.7 Pathogenic MLH1 P40692 S337I 337 S I 0.28 Neutral MLH1 P40692 S337K 337 S K 0.378 Neutral MLH1 P40692 S337L 337 S L 0.12 Neutral MLH1 P40692 S337M 337 S M 0.876 Pathogenic MLH1 P40692 S337N 337 S N 0.026 Neutral MLH1 P40692 S337P 337 S P 0.494 Neutral MLH1 P40692 S337Q 337 S Q 0.406 Neutral MLH1 P40692 S337R 337 S R 0.524 Pathogenic MLH1 P40692 S337T 337 S T 0.66 Pathogenic MLH1 P40692 S337V 337 S V 0.06 Neutral MLH1 P40692 S337W 337 S W 0.918 Pathogenic MLH1 P40692 S337Y 337 S Y 0.892 Pathogenic MLH1 P40692 N338A 338 N A 0.148 Neutral MLH1 P40692 N338C 338 N C 0.518 Pathogenic MLH1 P40692 N338D 338 N D 0.064 Neutral MLH1 P40692 N338E 338 N E 0.454 Neutral MLH1 P40692 N338F 338 N F 0.878 Pathogenic MLH1 P40692 N338G 338 N G 0.088 Neutral MLH1 P40692 N338H 338 N H 0.698 Pathogenic MLH1 P40692 N338I 338 N I 0.81 Pathogenic MLH1 P40692 N338K 338 N K 0.76 Pathogenic MLH1 P40692 N338L 338 N L 0.822 Pathogenic MLH1 P40692 N338M 338 N M 0.804 Pathogenic MLH1 P40692 N338P 338 N P 0.696 Pathogenic MLH1 P40692 N338Q 338 N Q 0.502 Pathogenic MLH1 P40692 N338R 338 N R 0.76 Pathogenic MLH1 P40692 N338S 338 N S 0.056 Neutral MLH1 P40692 N338T 338 N T 0.45 Neutral MLH1 P40692 N338V 338 N V 0.872 Pathogenic MLH1 P40692 N338W 338 N W 0.916 Pathogenic MLH1 P40692 N338Y 338 N Y 0.904 Pathogenic MLH1 P40692 S339A 339 S A 0.07 Neutral MLH1 P40692 S339C 339 S C 0.362 Neutral MLH1 P40692 S339D 339 S D 0.174 Neutral MLH1 P40692 S339E 339 S E 0.458 Neutral MLH1 P40692 S339F 339 S F 0.878 Pathogenic MLH1 P40692 S339G 339 S G 0.13 Neutral MLH1 P40692 S339H 339 S H 0.518 Pathogenic MLH1 P40692 S339I 339 S I 0.584 Pathogenic MLH1 P40692 S339K 339 S K 0.632 Pathogenic MLH1 P40692 S339L 339 S L 0.384 Neutral MLH1 P40692 S339M 339 S M 0.906 Pathogenic MLH1 P40692 S339N 339 S N 0.078 Neutral MLH1 P40692 S339P 339 S P 0.6 Pathogenic MLH1 P40692 S339Q 339 S Q 0.496 Neutral MLH1 P40692 S339R 339 S R 0.692 Pathogenic MLH1 P40692 S339T 339 S T 0.064 Neutral MLH1 P40692 S339V 339 S V 0.798 Pathogenic MLH1 P40692 S339W 339 S W 0.952 Pathogenic MLH1 P40692 S339Y 339 S Y 0.932 Pathogenic MLH1 P40692 E34A 34 E A 0.756 Pathogenic MLH1 P40692 E34C 34 E C 0.698 Pathogenic MLH1 P40692 E34D 34 E D 0.344 Neutral MLH1 P40692 E34F 34 E F 0.97 Pathogenic MLH1 P40692 E34G 34 E G 0.376 Neutral MLH1 P40692 E34H 34 E H 0.876 Pathogenic MLH1 P40692 E34I 34 E I 0.98 Pathogenic MLH1 P40692 E34K 34 E K 0.748 Pathogenic MLH1 P40692 E34L 34 E L 0.98 Pathogenic MLH1 P40692 E34M 34 E M 0.924 Pathogenic MLH1 P40692 E34N 34 E N 0.692 Pathogenic MLH1 P40692 E34P 34 E P 0.934 Pathogenic MLH1 P40692 E34Q 34 E Q 0.776 Pathogenic MLH1 P40692 E34R 34 E R 0.888 Pathogenic MLH1 P40692 E34S 34 E S 0.894 Pathogenic MLH1 P40692 E34T 34 E T 0.878 Pathogenic MLH1 P40692 E34V 34 E V 0.916 Pathogenic MLH1 P40692 E34W 34 E W 0.986 Pathogenic MLH1 P40692 E34Y 34 E Y 0.966 Pathogenic MLH1 P40692 S340A 340 S A 0.23 Neutral MLH1 P40692 S340C 340 S C 0.842 Pathogenic MLH1 P40692 S340D 340 S D 0.852 Pathogenic MLH1 P40692 S340E 340 S E 0.702 Pathogenic MLH1 P40692 S340F 340 S F 0.978 Pathogenic MLH1 P40692 S340G 340 S G 0.168 Neutral MLH1 P40692 S340H 340 S H 0.722 Pathogenic MLH1 P40692 S340I 340 S I 0.87 Pathogenic MLH1 P40692 S340K 340 S K 0.922 Pathogenic MLH1 P40692 S340L 340 S L 0.906 Pathogenic MLH1 P40692 S340M 340 S M 0.994 Pathogenic MLH1 P40692 S340N 340 S N 0.814 Pathogenic MLH1 P40692 S340P 340 S P 0.94 Pathogenic MLH1 P40692 S340Q 340 S Q 0.904 Pathogenic MLH1 P40692 S340R 340 S R 0.728 Pathogenic MLH1 P40692 S340T 340 S T 0.324 Neutral MLH1 P40692 S340V 340 S V 0.942 Pathogenic MLH1 P40692 S340W 340 S W 0.972 Pathogenic MLH1 P40692 S340Y 340 S Y 0.972 Pathogenic MLH1 P40692 R341A 341 R A 0.578 Pathogenic MLH1 P40692 R341C 341 R C 0.962 Pathogenic MLH1 P40692 R341D 341 R D 0.868 Pathogenic MLH1 P40692 R341E 341 R E 0.862 Pathogenic MLH1 P40692 R341F 341 R F 0.974 Pathogenic MLH1 P40692 R341G 341 R G 0.438 Neutral MLH1 P40692 R341H 341 R H 0.56 Pathogenic MLH1 P40692 R341I 341 R I 0.976 Pathogenic MLH1 P40692 R341K 341 R K 0.334 Neutral MLH1 P40692 R341L 341 R L 0.382 Neutral MLH1 P40692 R341M 341 R M 0.804 Pathogenic MLH1 P40692 R341N 341 R N 0.322 Neutral MLH1 P40692 R341P 341 R P 0.99 Pathogenic MLH1 P40692 R341Q 341 R Q 0.324 Neutral MLH1 P40692 R341S 341 R S 0.352 Neutral MLH1 P40692 R341T 341 R T 0.95 Pathogenic MLH1 P40692 R341V 341 R V 0.976 Pathogenic MLH1 P40692 R341W 341 R W 0.97 Pathogenic MLH1 P40692 R341Y 341 R Y 0.976 Pathogenic MLH1 P40692 M342A 342 M A 0.158 Neutral MLH1 P40692 M342C 342 M C 0.222 Neutral MLH1 P40692 M342D 342 M D 0.65 Pathogenic MLH1 P40692 M342E 342 M E 0.408 Neutral MLH1 P40692 M342F 342 M F 0.772 Pathogenic MLH1 P40692 M342G 342 M G 0.344 Neutral MLH1 P40692 M342H 342 M H 0.154 Neutral MLH1 P40692 M342I 342 M I 0.15 Neutral MLH1 P40692 M342K 342 M K 0.114 Neutral MLH1 P40692 M342L 342 M L 0.06 Neutral MLH1 P40692 M342N 342 M N 0.306 Neutral MLH1 P40692 M342P 342 M P 0.73 Pathogenic MLH1 P40692 M342Q 342 M Q 0.328 Neutral MLH1 P40692 M342R 342 M R 0.69 Pathogenic MLH1 P40692 M342S 342 M S 0.036 Neutral MLH1 P40692 M342T 342 M T 0.188 Neutral MLH1 P40692 M342V 342 M V 0.062 Neutral MLH1 P40692 M342W 342 M W 0.96 Pathogenic MLH1 P40692 M342Y 342 M Y 0.884 Pathogenic MLH1 P40692 Y343A 343 Y A 0.344 Neutral MLH1 P40692 Y343C 343 Y C 0.548 Pathogenic MLH1 P40692 Y343D 343 Y D 0.796 Pathogenic MLH1 P40692 Y343E 343 Y E 0.732 Pathogenic MLH1 P40692 Y343F 343 Y F 0.066 Neutral MLH1 P40692 Y343G 343 Y G 0.39 Neutral MLH1 P40692 Y343H 343 Y H 0.484 Neutral MLH1 P40692 Y343I 343 Y I 0.666 Pathogenic MLH1 P40692 Y343K 343 Y K 0.822 Pathogenic MLH1 P40692 Y343L 343 Y L 0.118 Neutral MLH1 P40692 Y343M 343 Y M 0.174 Neutral MLH1 P40692 Y343N 343 Y N 0.624 Pathogenic MLH1 P40692 Y343P 343 Y P 0.688 Pathogenic MLH1 P40692 Y343Q 343 Y Q 0.548 Pathogenic MLH1 P40692 Y343R 343 Y R 0.458 Neutral MLH1 P40692 Y343S 343 Y S 0.388 Neutral MLH1 P40692 Y343T 343 Y T 0.544 Pathogenic MLH1 P40692 Y343V 343 Y V 0.706 Pathogenic MLH1 P40692 Y343W 343 Y W 0.78 Pathogenic MLH1 P40692 F344A 344 F A 0.068 Neutral MLH1 P40692 F344C 344 F C 0.156 Neutral MLH1 P40692 F344D 344 F D 0.306 Neutral MLH1 P40692 F344E 344 F E 0.346 Neutral MLH1 P40692 F344G 344 F G 0.226 Neutral MLH1 P40692 F344H 344 F H 0.122 Neutral MLH1 P40692 F344I 344 F I 0.154 Neutral MLH1 P40692 F344K 344 F K 0.05 Neutral MLH1 P40692 F344L 344 F L 0.006 Neutral MLH1 P40692 F344M 344 F M 0.02 Neutral MLH1 P40692 F344N 344 F N 0.372 Neutral MLH1 P40692 F344P 344 F P 0.088 Neutral MLH1 P40692 F344Q 344 F Q 0.05 Neutral MLH1 P40692 F344R 344 F R 0.294 Neutral MLH1 P40692 F344S 344 F S 0.028 Neutral MLH1 P40692 F344T 344 F T 0.042 Neutral MLH1 P40692 F344V 344 F V 0.144 Neutral MLH1 P40692 F344W 344 F W 0.56 Pathogenic MLH1 P40692 F344Y 344 F Y 0.026 Neutral MLH1 P40692 T345A 345 T A 0.18 Neutral MLH1 P40692 T345C 345 T C 0.168 Neutral MLH1 P40692 T345D 345 T D 0.16 Neutral MLH1 P40692 T345E 345 T E 0.044 Neutral MLH1 P40692 T345F 345 T F 0.5 Pathogenic MLH1 P40692 T345G 345 T G 0.144 Neutral MLH1 P40692 T345H 345 T H 0.276 Neutral MLH1 P40692 T345I 345 T I 0.084 Neutral MLH1 P40692 T345K 345 T K 0.016 Neutral MLH1 P40692 T345L 345 T L 0.026 Neutral MLH1 P40692 T345M 345 T M 0.064 Neutral MLH1 P40692 T345N 345 T N 0.132 Neutral MLH1 P40692 T345P 345 T P 0.304 Neutral MLH1 P40692 T345Q 345 T Q 0.152 Neutral MLH1 P40692 T345R 345 T R 0.534 Pathogenic MLH1 P40692 T345S 345 T S 0.112 Neutral MLH1 P40692 T345V 345 T V 0.1 Neutral MLH1 P40692 T345W 345 T W 0.81 Pathogenic MLH1 P40692 T345Y 345 T Y 0.772 Pathogenic MLH1 P40692 Q346A 346 Q A 0.244 Neutral MLH1 P40692 Q346C 346 Q C 0.66 Pathogenic MLH1 P40692 Q346D 346 Q D 0.37 Neutral MLH1 P40692 Q346E 346 Q E 0.636 Pathogenic MLH1 P40692 Q346F 346 Q F 0.922 Pathogenic MLH1 P40692 Q346G 346 Q G 0.204 Neutral MLH1 P40692 Q346H 346 Q H 0.986 Pathogenic 5 MLH1 P40692 Q346I 346 Q I 0.952 Pathogenic MLH1 P40692 Q346K 346 Q K 0.362 Neutral MLH1 P40692 Q346L 346 Q L 0.764 Pathogenic MLH1 P40692 Q346M 346 Q M 0.908 Pathogenic MLH1 P40692 Q346N 346 Q N 0.366 Neutral MLH1 P40692 Q346P 346 Q P 0.916 Pathogenic MLH1 P40692 Q346R 346 Q R 0.83 Pathogenic MLH1 P40692 Q346S 346 Q S 0.238 Neutral MLH1 P40692 Q346T 346 Q T 0.676 Pathogenic MLH1 P40692 Q346V 346 Q V 0.92 Pathogenic MLH1 P40692 Q346W 346 Q W 0.96 Pathogenic MLH1 P40692 Q346Y 346 Q Y 0.95 Pathogenic MLH1 P40692 T347A 347 T A 0.036 Neutral MLH1 P40692 T347C 347 T C 0.13 Neutral MLH1 P40692 T347D 347 T D 0.524 Pathogenic MLH1 P40692 T347E 347 T E 0.504 Pathogenic MLH1 P40692 T347F 347 T F 0.752 Pathogenic MLH1 P40692 T347G 347 T G 0.148 Neutral MLH1 P40692 T347H 347 T H 0.596 Pathogenic MLH1 P40692 T347I 347 T I 0.45 Neutral MLH1 P40692 T347K 347 T K 0.114 Neutral MLH1 P40692 T347L 347 T L 0.094 Neutral MLH1 P40692 T347M 347 T M 0.538 Pathogenic MLH1 P40692 T347N 347 T N 0.076 Neutral 1 MLH1 P40692 T347P 347 T P 0.078 Neutral MLH1 P40692 T347Q 347 T Q 0.176 Neutral MLH1 P40692 T347R 347 T R 0.842 Pathogenic MLH1 P40692 T347S 347 T S 0.006 Neutral MLH1 P40692 T347V 347 T V 0.074 Neutral MLH1 P40692 T347W 347 T W 0.946 Pathogenic MLH1 P40692 T347Y 347 T Y 0.754 Pathogenic MLH1 P40692 L348A 348 L A 0.156 Neutral MLH1 P40692 L348C 348 L C 0.332 Neutral MLH1 P40692 L348D 348 L D 0.606 Pathogenic MLH1 P40692 L348E 348 L E 0.448 Neutral MLH1 P40692 L348F 348 L F 0.306 Neutral MLH1 P40692 L348G 348 L G 0.494 Neutral MLH1 P40692 L348H 348 L H 0.086 Neutral MLH1 P40692 L348I 348 L I 0.04 Neutral MLH1 P40692 L348K 348 L K 0.04 Neutral MLH1 P40692 L348M 348 L M 0.07 Neutral MLH1 P40692 L348N 348 L N 0.518 Pathogenic MLH1 P40692 L348P 348 L P 0.898 Pathogenic MLH1 P40692 L348Q 348 L Q 0.038 Neutral MLH1 P40692 L348R 348 L R 0.55 Pathogenic MLH1 P40692 L348S 348 L S 0.456 Neutral MLH1 P40692 L348T 348 L T 0.226 Neutral MLH1 P40692 L348V 348 L V 0.01 Neutral MLH1 P40692 L348W 348 L W 0.868 Pathogenic MLH1 P40692 L348Y 348 L Y 0.76 Pathogenic MLH1 P40692 L349A 349 L A 0.044 Neutral MLH1 P40692 L349C 349 L C 0.41 Neutral MLH1 P40692 L349D 349 L D 0.678 Pathogenic MLH1 P40692 L349E 349 L E 0.634 Pathogenic MLH1 P40692 L349F 349 L F 0.35 Neutral MLH1 P40692 L349G 349 L G 0.442 Neutral MLH1 P40692 L349H 349 L H 0.434 Neutral MLH1 P40692 L349I 349 L I 0.054 Neutral MLH1 P40692 L349K 349 L K 0.4 Neutral MLH1 P40692 L349M 349 L M 0.018 Neutral MLH1 P40692 L349N 349 L N 0.622 Pathogenic MLH1 P40692 L349P 349 L P 0.95 Pathogenic MLH1 P40692 L349Q 349 L Q 0.194 Neutral MLH1 P40692 L349R 349 L R 0.598 Pathogenic MLH1 P40692 L349S 349 L S 0.07 Neutral MLH1 P40692 L349T 349 L T 0.036 Neutral MLH1 P40692 L349V 349 L V 0.134 Neutral MLH1 P40692 L349W 349 L W 0.844 Pathogenic MLH1 P40692 L349Y 349 L Y 0.836 Pathogenic MLH1 P40692 M35A 35 M A 0.516 Pathogenic MLH1 P40692 M35C 35 M C 0.428 Neutral MLH1 P40692 M35D 35 M D 0.884 Pathogenic MLH1 P40692 M35E 35 M E 0.666 Pathogenic MLH1 P40692 M35F 35 M F 0.722 Pathogenic MLH1 P40692 M35G 35 M G 0.544 Pathogenic MLH1 P40692 M35H 35 M H 0.698 Pathogenic MLH1 P40692 M35I 35 M I 0.438 Neutral MLH1 P40692 M35K 35 M K 0.806 Pathogenic MLH1 P40692 M35L 35 M L 0.198 Neutral MLH1 P40692 M35N 35 M N 0.944 Pathogenic 5 MLH1 P40692 M35P 35 M P 0.886 Pathogenic MLH1 P40692 M35Q 35 M Q 0.622 Pathogenic MLH1 P40692 M35R 35 M R 0.946 Pathogenic 5 MLH1 P40692 M35S 35 M S 0.392 Neutral MLH1 P40692 M35T 35 M T 0.61 Pathogenic MLH1 P40692 M35V 35 M V 0.474 Neutral MLH1 P40692 M35W 35 M W 0.918 Pathogenic MLH1 P40692 M35Y 35 M Y 0.862 Pathogenic MLH1 P40692 P350A 350 P A 0.122 Neutral MLH1 P40692 P350C 350 P C 0.646 Pathogenic MLH1 P40692 P350D 350 P D 0.464 Neutral MLH1 P40692 P350E 350 P E 0.746 Pathogenic MLH1 P40692 P350F 350 P F 0.97 Pathogenic MLH1 P40692 P350G 350 P G 0.154 Neutral MLH1 P40692 P350H 350 P H 0.764 Pathogenic MLH1 P40692 P350I 350 P I 0.652 Pathogenic MLH1 P40692 P350K 350 P K 0.708 Pathogenic MLH1 P40692 P350L 350 P L 0.336 Neutral MLH1 P40692 P350M 350 P M 0.748 Pathogenic MLH1 P40692 P350N 350 P N 0.056 Neutral MLH1 P40692 P350Q 350 P Q 0.69 Pathogenic MLH1 P40692 P350R 350 P R 0.872 Pathogenic MLH1 P40692 P350S 350 P S 0.024 Neutral MLH1 P40692 P350T 350 P T 0.038 Neutral MLH1 P40692 P350V 350 P V 0.524 Pathogenic MLH1 P40692 P350W 350 P W 0.908 Pathogenic MLH1 P40692 P350Y 350 P Y 0.846 Pathogenic MLH1 P40692 G351A 351 G A 0.014 Neutral MLH1 P40692 G351C 351 G C 0.498 Neutral MLH1 P40692 G351D 351 G D 0.544 Pathogenic MLH1 P40692 G351E 351 G E 0.496 Neutral MLH1 P40692 G351F 351 G F 0.874 Pathogenic MLH1 P40692 G351H 351 G H 0.83 Pathogenic MLH1 P40692 G351I 351 G I 0.596 Pathogenic MLH1 P40692 G351K 351 G K 0.474 Neutral MLH1 P40692 G351L 351 G L 0.506 Pathogenic MLH1 P40692 G351M 351 G M 0.5 Pathogenic MLH1 P40692 G351N 351 G N 0.456 Neutral MLH1 P40692 G351P 351 G P 0.808 Pathogenic MLH1 P40692 G351Q 351 G Q 0.374 Neutral MLH1 P40692 G351R 351 G R 0.784 Pathogenic MLH1 P40692 G351S 351 G S 0.04 Neutral MLH1 P40692 G351T 351 G T 0.448 Neutral MLH1 P40692 G351V 351 G V 0.618 Pathogenic MLH1 P40692 G351W 351 G W 0.876 Pathogenic MLH1 P40692 G351Y 351 G Y 0.866 Pathogenic MLH1 P40692 L352A 352 L A 0.008 Neutral MLH1 P40692 L352C 352 L C 0.094 Neutral MLH1 P40692 L352D 352 L D 0.172 Neutral MLH1 P40692 L352E 352 L E 0.16 Neutral MLH1 P40692 L352F 352 L F 0.232 Neutral MLH1 P40692 L352G 352 L G 0.052 Neutral MLH1 P40692 L352H 352 L H 0.01 Neutral MLH1 P40692 L352I 352 L I 0.002 Neutral MLH1 P40692 L352K 352 L K 0.088 Neutral MLH1 P40692 L352M 352 L M 0.012 Neutral MLH1 P40692 L352N 352 L N 0.044 Neutral MLH1 P40692 L352P 352 L P 0.096 Neutral MLH1 P40692 L352Q 352 L Q 0.048 Neutral MLH1 P40692 L352R 352 L R 0.276 Neutral MLH1 P40692 L352S 352 L S 0.01 Neutral MLH1 P40692 L352T 352 L T 0.012 Neutral MLH1 P40692 L352V 352 L V 0 Neutral MLH1 P40692 L352W 352 L W 0.384 Neutral MLH1 P40692 L352Y 352 L Y 0.338 Neutral MLH1 P40692 A353C 353 A C 0.182 Neutral MLH1 P40692 A353D 353 A D 0.342 Neutral MLH1 P40692 A353E 353 A E 0.29 Neutral MLH1 P40692 A353F 353 A F 0.408 Neutral MLH1 P40692 A353G 353 A G 0.006 Neutral MLH1 P40692 A353H 353 A H 0.304 Neutral MLH1 P40692 A353I 353 A I 0.396 Neutral MLH1 P40692 A353K 353 A K 0.254 Neutral MLH1 P40692 A353L 353 A L 0.414 Neutral MLH1 P40692 A353M 353 A M 0.29 Neutral MLH1 P40692 A353N 353 A N 0.314 Neutral MLH1 P40692 A353P 353 A P 0.04 Neutral MLH1 P40692 A353Q 353 A Q 0.286 Neutral MLH1 P40692 A353R 353 A R 0.326 Neutral MLH1 P40692 A353S 353 A S 0.004 Neutral MLH1 P40692 A353T 353 A T 0.018 Neutral MLH1 P40692 A353V 353 A V 0.136 Neutral MLH1 P40692 A353W 353 A W 0.504 Pathogenic MLH1 P40692 A353Y 353 A Y 0.5 Pathogenic MLH1 P40692 G354A 354 G A 0.002 Neutral MLH1 P40692 G354C 354 G C 0.186 Neutral MLH1 P40692 G354D 354 G D 0.134 Neutral MLH1 P40692 G354E 354 G E 0.192 Neutral MLH1 P40692 G354F 354 G F 0.498 Neutral MLH1 P40692 G354H 354 G H 0.294 Neutral MLH1 P40692 G354I 354 G I 0.394 Neutral MLH1 P40692 G354K 354 G K 0.284 Neutral MLH1 P40692 G354L 354 G L 0.37 Neutral MLH1 P40692 G354M 354 G M 0.422 Neutral MLH1 P40692 G354N 354 G N 0.18 Neutral MLH1 P40692 G354P 354 G P 0.364 Neutral MLH1 P40692 G354Q 354 G Q 0.206 Neutral MLH1 P40692 G354R 354 G R 0.31 Neutral MLH1 P40692 G354S 354 G S 0.016 Neutral MLH1 P40692 G354T 354 G T 0.266 Neutral MLH1 P40692 G354V 354 G V 0.318 Neutral MLH1 P40692 G354W 354 G W 0.498 Neutral MLH1 P40692 G354Y 354 G Y 0.5 Pathogenic MLH1 P40692 P355A 355 P A 0.034 Neutral MLH1 P40692 P355C 355 P C 0.136 Neutral MLH1 P40692 P355D 355 P D 0.01 Neutral MLH1 P40692 P355E 355 P E 0.068 Neutral MLH1 P40692 P355F 355 P F 0.296 Neutral MLH1 P40692 P355G 355 P G 0.01 Neutral MLH1 P40692 P355H 355 P H 0.302 Neutral MLH1 P40692 P355I 355 P I 0.05 Neutral MLH1 P40692 P355K 355 P K 0.066 Neutral MLH1 P40692 P355L 355 P L 0.05 Neutral MLH1 P40692 P355M 355 P M 0.176 Neutral MLH1 P40692 P355N 355 P N 0.004 Neutral MLH1 P40692 P355Q 355 P Q 0.12 Neutral MLH1 P40692 P355R 355 P R 0.264 Neutral MLH1 P40692 P355S 355 P S 0.006 Neutral MLH1 P40692 P355T 355 P T 0.012 Neutral MLH1 P40692 P355V 355 P V 0.044 Neutral MLH1 P40692 P355W 355 P W 0.462 Neutral MLH1 P40692 P355Y 355 P Y 0.346 Neutral MLH1 P40692 S356A 356 S A 0.01 Neutral MLH1 P40692 S356C 356 S C 0.066 Neutral MLH1 P40692 S356D 356 S D 0.006 Neutral MLH1 P40692 S356E 356 S E 0.228 Neutral MLH1 P40692 S356F 356 S F 0.526 Pathogenic MLH1 P40692 S356G 356 S G 0.002 Neutral MLH1 P40692 S356H 356 S H 0.45 Neutral MLH1 P40692 S356I 356 S I 0.232 Neutral MLH1 P40692 S356K 356 S K 0.252 Neutral MLH1 P40692 S356L 356 S L 0.128 Neutral MLH1 P40692 S356M 356 S M 0.576 Pathogenic MLH1 P40692 S356N 356 S N 0.006 Neutral MLH1 P40692 S356P 356 S P 0.076 Neutral MLH1 P40692 S356Q 356 S Q 0.266 Neutral MLH1 P40692 S356R 356 S R 0.234 Neutral MLH1 P40692 S356T 356 S T 0.016 Neutral MLH1 P40692 S356V 356 S V 0.05 Neutral MLH1 P40692 S356W 356 S W 0.752 Pathogenic MLH1 P40692 S356Y 356 S Y 0.696 Pathogenic MLH1 P40692 G357A 357 G A 0.006 Neutral MLH1 P40692 G357C 357 G C 0.368 Neutral MLH1 P40692 G357D 357 G D 0.224 Neutral MLH1 P40692 G357E 357 G E 0.302 Neutral MLH1 P40692 G357F 357 G F 0.768 Pathogenic MLH1 P40692 G357H 357 G H 0.476 Neutral MLH1 P40692 G357I 357 G I 0.7 Pathogenic MLH1 P40692 G357K 357 G K 0.392 Neutral MLH1 P40692 G357L 357 G L 0.438 Neutral MLH1 P40692 G357M 357 G M 0.614 Pathogenic MLH1 P40692 G357N 357 G N 0.264 Neutral MLH1 P40692 G357P 357 G P 0.452 Neutral MLH1 P40692 G357Q 357 G Q 0.278 Neutral MLH1 P40692 G357R 357 G R 0.414 Neutral MLH1 P40692 G357S 357 G S 0.024 Neutral MLH1 P40692 G357T 357 G T 0.356 Neutral MLH1 P40692 G357V 357 G V 0.416 Neutral MLH1 P40692 G357W 357 G W 0.766 Pathogenic MLH1 P40692 G357Y 357 G Y 0.75 Pathogenic MLH1 P40692 E358A 358 E A 0.076 Neutral MLH1 P40692 E358C 358 E C 0.108 Neutral MLH1 P40692 E358D 358 E D 0.002 Neutral MLH1 P40692 E358F 358 E F 0.134 Neutral MLH1 P40692 E358G 358 E G 0 Neutral MLH1 P40692 E358H 358 E H 0.17 Neutral MLH1 P40692 E358I 358 E I 0.204 Neutral MLH1 P40692 E358K 358 E K 0.002 Neutral MLH1 P40692 E358L 358 E L 0.06 Neutral MLH1 P40692 E358M 358 E M 0.294 Neutral MLH1 P40692 E358N 358 E N 0.002 Neutral MLH1 P40692 E358P 358 E P 0.062 Neutral MLH1 P40692 E358Q 358 E Q 0 Neutral MLH1 P40692 E358R 358 E R 0.02 Neutral MLH1 P40692 E358S 358 E S 0.016 Neutral MLH1 P40692 E358T 358 E T 0.01 Neutral MLH1 P40692 E358V 358 E V 0.048 Neutral MLH1 P40692 E358W 358 E W 0.706 Pathogenic MLH1 P40692 E358Y 358 E Y 0.588 Pathogenic MLH1 P40692 M359A 359 M A 0.046 Neutral MLH1 P40692 M359C 359 M C 0 Neutral MLH1 P40692 M359D 359 M D 0.064 Neutral MLH1 P40692 M359E 359 M E 0.01 Neutral MLH1 P40692 M359F 359 M F 0.078 Neutral MLH1 P40692 M359G 359 M G 0.038 Neutral MLH1 P40692 M359H 359 M H 0.058 Neutral MLH1 P40692 M359I 359 M I 0.004 Neutral MLH1 P40692 M359K 359 M K 0.02 Neutral MLH1 P40692 M359L 359 M L 0.004 Neutral MLH1 P40692 M359N 359 M N 0.078 Neutral MLH1 P40692 M359P 359 M P 0.036 Neutral MLH1 P40692 M359Q 359 M Q 0.002 Neutral MLH1 P40692 M359R 359 M R 0.05 Neutral MLH1 P40692 M359S 359 M S 0.014 Neutral MLH1 P40692 M359T 359 M T 0.012 Neutral MLH1 P40692 M359V 359 M V 0.022 Neutral MLH1 P40692 M359W 359 M W 0.492 Neutral MLH1 P40692 M359Y 359 M Y 0.246 Neutral MLH1 P40692 I36A 36 I A 0.27 Neutral MLH1 P40692 I36C 36 I C 0.416 Neutral MLH1 P40692 I36D 36 I D 0.616 Pathogenic MLH1 P40692 I36E 36 I E 0.48 Neutral MLH1 P40692 I36F 36 I F 0.558 Pathogenic MLH1 P40692 I36G 36 I G 0.594 Pathogenic MLH1 P40692 I36H 36 I H 0.486 Neutral MLH1 P40692 I36K 36 I K 0.612 Pathogenic MLH1 P40692 I36L 36 I L 0.01 Neutral MLH1 P40692 I36M 36 I M 0.05 Neutral MLH1 P40692 I36N 36 I N 0.66 Pathogenic MLH1 P40692 I36P 36 I P 0.568 Pathogenic MLH1 P40692 I36Q 36 I Q 0.634 Pathogenic MLH1 P40692 I36R 36 I R 0.83 Pathogenic MLH1 P40692 I36S 36 I S 0.432 Neutral MLH1 P40692 I36T 36 I T 0.332 Neutral MLH1 P40692 I36V 36 I V 0.012 Neutral MLH1 P40692 I36W 36 I W 0.9 Pathogenic MLH1 P40692 I36Y 36 I Y 0.898 Pathogenic MLH1 P40692 V360A 360 V A 0 Neutral MLH1 P40692 V360C 360 V C 0.11 Neutral MLH1 P40692 V360D 360 V D 0.034 Neutral MLH1 P40692 V360E 360 V E 0.062 Neutral MLH1 P40692 V360F 360 V F 0.376 Neutral MLH1 P40692 V360G 360 V G 0.048 Neutral MLH1 P40692 V360H 360 V H 0.23 Neutral MLH1 P40692 V360I 360 V I 0.054 Neutral MLH1 P40692 V360K 360 V K 0.082 Neutral MLH1 P40692 V360L 360 V L 0 Neutral MLH1 P40692 V360M 360 V M 0.12 Neutral MLH1 P40692 V360N 360 V N 0.05 Neutral MLH1 P40692 V360P 360 V P 0.048 Neutral MLH1 P40692 V360Q 360 V Q 0.072 Neutral MLH1 P40692 V360R 360 V R 0.314 Neutral MLH1 P40692 V360S 360 V S 0.014 Neutral MLH1 P40692 V360T 360 V T 0.008 Neutral MLH1 P40692 V360W 360 V W 0.554 Pathogenic MLH1 P40692 V360Y 360 V Y 0.472 Neutral MLH1 P40692 K361A 361 K A 0.032 Neutral MLH1 P40692 K361C 361 K C 0.058 Neutral MLH1 P40692 K361D 361 K D 0.002 Neutral MLH1 P40692 K361E 361 K E 0.004 Neutral MLH1 P40692 K361F 361 K F 0.054 Neutral MLH1 P40692 K361G 361 K G 0.05 Neutral MLH1 P40692 K361H 361 K H 0.016 Neutral MLH1 P40692 K361I 361 K I 0.186 Neutral MLH1 P40692 K361L 361 K L 0.048 Neutral MLH1 P40692 K361M 361 K M 0.236 Neutral MLH1 P40692 K361N 361 K N 0.008 Neutral MLH1 P40692 K361P 361 K P 0.028 Neutral MLH1 P40692 K361Q 361 K Q 0.01 Neutral MLH1 P40692 K361R 361 K R 0.006 Neutral MLH1 P40692 K361S 361 K S 0.014 Neutral MLH1 P40692 K361T 361 K T 0.016 Neutral MLH1 P40692 K361V 361 K V 0.042 Neutral MLH1 P40692 K361W 361 K W 0.678 Pathogenic MLH1 P40692 K361Y 361 K Y 0.582 Pathogenic MLH1 P40692 S362A 362 S A 0.014 Neutral MLH1 P40692 S362C 362 S C 0.072 Neutral MLH1 P40692 S362D 362 S D 0.022 Neutral MLH1 P40692 S362E 362 S E 0.232 Neutral MLH1 P40692 S362F 362 S F 0.372 Neutral MLH1 P40692 S362G 362 S G 0.088 Neutral MLH1 P40692 S362H 362 S H 0.262 Neutral MLH1 P40692 S362I 362 S I 0.158 Neutral MLH1 P40692 S362K 362 S K 0.24 Neutral MLH1 P40692 S362L 362 S L 0.162 Neutral MLH1 P40692 S362M 362 S M 0.608 Pathogenic MLH1 P40692 S362N 362 S N 0.016 Neutral MLH1 P40692 S362P 362 S P 0.072 Neutral MLH1 P40692 S362Q 362 S Q 0.27 Neutral MLH1 P40692 S362R 362 S R 0.252 Neutral MLH1 P40692 S362T 362 S T 0.026 Neutral MLH1 P40692 S362V 362 S V 0.058 Neutral MLH1 P40692 S362W 362 S W 0.724 Pathogenic MLH1 P40692 S362Y 362 S Y 0.558 Pathogenic MLH1 P40692 T363A 363 T A 0.004 Neutral MLH1 P40692 T363C 363 T C 0.076 Neutral MLH1 P40692 T363D 363 T D 0.088 Neutral MLH1 P40692 T363E 363 T E 0.1 Neutral MLH1 P40692 T363F 363 T F 0.4 Neutral MLH1 P40692 T363G 363 T G 0.004 Neutral MLH1 P40692 T363H 363 T H 0.136 Neutral MLH1 P40692 T363I 363 T I 0.074 Neutral MLH1 P40692 T363K 363 T K 0.014 Neutral MLH1 P40692 T363L 363 T L 0.042 Neutral MLH1 P40692 T363M 363 T M 0.126 Neutral MLH1 P40692 T363N 363 T N 0.002 Neutral MLH1 P40692 T363P 363 T P 0.026 Neutral MLH1 P40692 T363Q 363 T Q 0.006 Neutral MLH1 P40692 T363R 363 T R 0.232 Neutral MLH1 P40692 T363S 363 T S 0.002 Neutral MLH1 P40692 T363V 363 T V 0.022 Neutral MLH1 P40692 T363W 363 T W 0.724 Pathogenic MLH1 P40692 T363Y 363 T Y 0.422 Neutral MLH1 P40692 T364A 364 T A 0 Neutral MLH1 P40692 T364C 364 T C 0.074 Neutral MLH1 P40692 T364D 364 T D 0.024 Neutral MLH1 P40692 T364E 364 T E 0.026 Neutral MLH1 P40692 T364F 364 T F 0.298 Neutral MLH1 P40692 T364G 364 T G 0.002 Neutral MLH1 P40692 T364H 364 T H 0.114 Neutral MLH1 P40692 T364I 364 T I 0.052 Neutral MLH1 P40692 T364K 364 T K 0.002 Neutral MLH1 P40692 T364L 364 T L 0.012 Neutral MLH1 P40692 T364M 364 T M 0.036 Neutral MLH1 P40692 T364N 364 T N 0 Neutral MLH1 P40692 T364P 364 T P 0.016 Neutral MLH1 P40692 T364Q 364 T Q 0 Neutral MLH1 P40692 T364R 364 T R 0.168 Neutral MLH1 P40692 T364S 364 T S 0 Neutral MLH1 P40692 T364V 364 T V 0.018 Neutral MLH1 P40692 T364W 364 T W 0.572 Pathogenic MLH1 P40692 T364Y 364 T Y 0.532 Pathogenic MLH1 P40692 S365A 365 S A 0.01 Neutral MLH1 P40692 S365C 365 S C 0.076 Neutral MLH1 P40692 S365D 365 S D 0.008 Neutral MLH1 P40692 S365E 365 S E 0.226 Neutral MLH1 P40692 S365F 365 S F 0.368 Neutral MLH1 P40692 S365G 365 S G 0.002 Neutral MLH1 P40692 S365H 365 S H 0.29 Neutral MLH1 P40692 S365I 365 S I 0.222 Neutral MLH1 P40692 S365K 365 S K 0.252 Neutral MLH1 P40692 S365L 365 S L 0.058 Neutral MLH1 P40692 S365M 365 S M 0.382 Neutral MLH1 P40692 S365N 365 S N 0.008 Neutral MLH1 P40692 S365P 365 S P 0.078 Neutral MLH1 P40692 S365Q 365 S Q 0.266 Neutral MLH1 P40692 S365R 365 S R 0.244 Neutral MLH1 P40692 S365T 365 S T 0.016 Neutral MLH1 P40692 S365V 365 S V 0.1 Neutral MLH1 P40692 S365W 365 S W 0.744 Pathogenic MLH1 P40692 S365Y 365 S Y 0.702 Pathogenic MLH1 P40692 L366A 366 L A 0.008 Neutral MLH1 P40692 L366C 366 L C 0.094 Neutral MLH1 P40692 L366D 366 L D 0.044 Neutral MLH1 P40692 L366E 366 L E 0.034 Neutral MLH1 P40692 L366F 366 L F 0.232 Neutral MLH1 P40692 L366G 366 L G 0.052 Neutral MLH1 P40692 L366H 366 L H 0.084 Neutral MLH1 P40692 L366I 366 L I 0.002 Neutral MLH1 P40692 L366K 366 L K 0.02 Neutral MLH1 P40692 L366M 366 L M 0.032 Neutral MLH1 P40692 L366N 366 L N 0.146 Neutral MLH1 P40692 L366P 366 L P 0.092 Neutral MLH1 P40692 L366Q 366 L Q 0.004 Neutral MLH1 P40692 L366R 366 L R 0.268 Neutral MLH1 P40692 L366S 366 L S 0.01 Neutral MLH1 P40692 L366T 366 L T 0.012 Neutral MLH1 P40692 L366V 366 L V 0 Neutral MLH1 P40692 L366W 366 L W 0.384 Neutral MLH1 P40692 L366Y 366 L Y 0.338 Neutral MLH1 P40692 T367A 367 T A 0 Neutral MLH1 P40692 T367C 367 T C 0.12 Neutral MLH1 P40692 T367D 367 T D 0.038 Neutral MLH1 P40692 T367E 367 T E 0.04 Neutral MLH1 P40692 T367F 367 T F 0.428 Neutral MLH1 P40692 T367G 367 T G 0.002 Neutral MLH1 P40692 T367H 367 T H 0.134 Neutral MLH1 P40692 T367I 367 T I 0.056 Neutral MLH1 P40692 T367K 367 T K 0.02 Neutral MLH1 P40692 T367L 367 T L 0.02 Neutral MLH1 P40692 T367M 367 T M 0.284 Neutral MLH1 P40692 T367N 367 T N 0 Neutral MLH1 P40692 T367P 367 T P 0.026 Neutral MLH1 P40692 T367Q 367 T Q 0.004 Neutral MLH1 P40692 T367R 367 T R 0.242 Neutral MLH1 P40692 T367S 367 T S 0 Neutral MLH1 P40692 T367V 367 T V 0.02 Neutral MLH1 P40692 T367W 367 T W 0.72 Pathogenic MLH1 P40692 T367Y 367 T Y 0.418 Neutral MLH1 P40692 S368A 368 S A 0.012 Neutral MLH1 P40692 S368C 368 S C 0.076 Neutral MLH1 P40692 S368D 368 S D 0.006 Neutral MLH1 P40692 S368E 368 S E 0.226 Neutral MLH1 P40692 S368F 368 S F 0.518 Pathogenic MLH1 P40692 S368G 368 S G 0.02 Neutral MLH1 P40692 S368H 368 S H 0.376 Neutral MLH1 P40692 S368I 368 S I 0.228 Neutral MLH1 P40692 S368K 368 S K 0.252 Neutral MLH1 P40692 S368L 368 S L 0.058 Neutral MLH1 P40692 S368M 368 S M 0.62 Pathogenic MLH1 P40692 S368N 368 S N 0.006 Neutral MLH1 P40692 S368P 368 S P 0.068 Neutral MLH1 P40692 S368Q 368 S Q 0.268 Neutral MLH1 P40692 S368R 368 S R 0.244 Neutral MLH1 P40692 S368T 368 S T 0.024 Neutral MLH1 P40692 S368V 368 S V 0.2 Neutral MLH1 P40692 S368W 368 S W 0.736 Pathogenic MLH1 P40692 S368Y 368 S Y 0.692 Pathogenic MLH1 P40692 S369A 369 S A 0.01 Neutral MLH1 P40692 S369C 369 S C 0.032 Neutral MLH1 P40692 S369D 369 S D 0.044 Neutral MLH1 P40692 S369E 369 S E 0.152 Neutral MLH1 P40692 S369F 369 S F 0.25 Neutral MLH1 P40692 S369G 369 S G 0.01 Neutral MLH1 P40692 S369H 369 S H 0.242 Neutral MLH1 P40692 S369I 369 S I 0.026 Neutral MLH1 P40692 S369K 369 S K 0.146 Neutral MLH1 P40692 S369L 369 S L 0.042 Neutral MLH1 P40692 S369M 369 S M 0.35 Neutral MLH1 P40692 S369N 369 S N 0.014 Neutral MLH1 P40692 S369P 369 S P 0.066 Neutral MLH1 P40692 S369Q 369 S Q 0.138 Neutral MLH1 P40692 S369R 369 S R 0.252 Neutral MLH1 P40692 S369T 369 S T 0.024 Neutral MLH1 P40692 S369V 369 S V 0.036 Neutral MLH1 P40692 S369W 369 S W 0.502 Pathogenic MLH1 P40692 S369Y 369 S Y 0.458 Neutral MLH1 P40692 E37A 37 E A 0.76 Pathogenic MLH1 P40692 E37C 37 E C 0.704 Pathogenic MLH1 P40692 E37D 37 E D 0.822 Pathogenic MLH1 P40692 E37F 37 E F 0.972 Pathogenic MLH1 P40692 E37G 37 E G 0.38 Neutral MLH1 P40692 E37H 37 E H 0.876 Pathogenic MLH1 P40692 E37I 37 E I 0.982 Pathogenic MLH1 P40692 E37K 37 E K 0.982 Pathogenic MLH1 P40692 E37L 37 E L 0.982 Pathogenic MLH1 P40692 E37M 37 E M 0.926 Pathogenic MLH1 P40692 E37N 37 E N 0.698 Pathogenic MLH1 P40692 E37P 37 E P 0.662 Pathogenic MLH1 P40692 E37Q 37 E Q 0.78 Pathogenic MLH1 P40692 E37R 37 E R 0.89 Pathogenic MLH1 P40692 E37S 37 E S 0.9 Pathogenic MLH1 P40692 E37T 37 E T 0.886 Pathogenic MLH1 P40692 E37V 37 E V 0.918 Pathogenic MLH1 P40692 E37W 37 E W 0.986 Pathogenic MLH1 P40692 E37Y 37 E Y 0.966 Pathogenic MLH1 P40692 S370A 370 S A 0.01 Neutral MLH1 P40692 S370C 370 S C 0.032 Neutral MLH1 P40692 S370D 370 S D 0.024 Neutral MLH1 P40692 S370E 370 S E 0.148 Neutral MLH1 P40692 S370F 370 S F 0.276 Neutral MLH1 P40692 S370G 370 S G 0 Neutral MLH1 P40692 S370H 370 S H 0.238 Neutral MLH1 P40692 S370I 370 S I 0.026 Neutral MLH1 P40692 S370K 370 S K 0.14 Neutral MLH1 P40692 S370L 370 S L 0.028 Neutral MLH1 P40692 S370M 370 S M 0.332 Neutral MLH1 P40692 S370N 370 S N 0.018 Neutral MLH1 P40692 S370P 370 S P 0.098 Neutral MLH1 P40692 S370Q 370 S Q 0.132 Neutral MLH1 P40692 S370R 370 S R 0.152 Neutral MLH1 P40692 S370T 370 S T 0.022 Neutral MLH1 P40692 S370V 370 S V 0.134 Neutral MLH1 P40692 S370W 370 S W 0.49 Neutral MLH1 P40692 S370Y 370 S Y 0.448 Neutral MLH1 P40692 T371A 371 T A 0 Neutral MLH1 P40692 T371C 371 T C 0.064 Neutral MLH1 P40692 T371D 371 T D 0.038 Neutral MLH1 P40692 T371E 371 T E 0.024 Neutral MLH1 P40692 T371F 371 T F 0.214 Neutral MLH1 P40692 T371G 371 T G 0.002 Neutral MLH1 P40692 T371H 371 T H 0.084 Neutral MLH1 P40692 T371I 371 T I 0.096 Neutral MLH1 P40692 T371K 371 T K 0.032 Neutral MLH1 P40692 T371L 371 T L 0.07 Neutral MLH1 P40692 T371M 371 T M 0.098 Neutral MLH1 P40692 T371N 371 T N 0.012 Neutral MLH1 P40692 T371P 371 T P 0.02 Neutral MLH1 P40692 T371Q 371 T Q 0.016 Neutral MLH1 P40692 T371R 371 T R 0.26 Neutral MLH1 P40692 T371S 371 T S 0 Neutral MLH1 P40692 T371V 371 T V 0.212 Neutral MLH1 P40692 T371W 371 T W 0.466 Neutral MLH1 P40692 T371Y 371 T Y 0.424 Neutral MLH1 P40692 S372A 372 S A 0.01 Neutral MLH1 P40692 S372C 372 S C 0.032 Neutral MLH1 P40692 S372D 372 S D 0.002 Neutral MLH1 P40692 S372E 372 S E 0.114 Neutral MLH1 P40692 S372F 372 S F 0.276 Neutral MLH1 P40692 S372G 372 S G 0.066 Neutral MLH1 P40692 S372H 372 S H 0.238 Neutral MLH1 P40692 S372I 372 S I 0.026 Neutral MLH1 P40692 S372K 372 S K 0.162 Neutral MLH1 P40692 S372L 372 S L 0.028 Neutral MLH1 P40692 S372M 372 S M 0.332 Neutral MLH1 P40692 S372N 372 S N 0.034 Neutral MLH1 P40692 S372P 372 S P 0.098 Neutral MLH1 P40692 S372Q 372 S Q 0.188 Neutral MLH1 P40692 S372R 372 S R 0.156 Neutral MLH1 P40692 S372T 372 S T 0.104 Neutral MLH1 P40692 S372V 372 S V 0.034 Neutral MLH1 P40692 S372W 372 S W 0.49 Neutral MLH1 P40692 S372Y 372 S Y 0.448 Neutral MLH1 P40692 G373A 373 G A 0.004 Neutral MLH1 P40692 G373C 373 G C 0.23 Neutral MLH1 P40692 G373D 373 G D 0.148 Neutral MLH1 P40692 G373E 373 G E 0.284 Neutral MLH1 P40692 G373F 373 G F 0.612 Pathogenic MLH1 P40692 G373H 373 G H 0.552 Pathogenic MLH1 P40692 G373I 373 G I 0.554 Pathogenic MLH1 P40692 G373K 373 G K 0.31 Neutral MLH1 P40692 G373L 373 G L 0.538 Pathogenic MLH1 P40692 G373M 373 G M 0.542 Pathogenic MLH1 P40692 G373N 373 G N 0.246 Neutral MLH1 P40692 G373P 373 G P 0.496 Neutral MLH1 P40692 G373Q 373 G Q 0.244 Neutral MLH1 P40692 G373R 373 G R 0.39 Neutral MLH1 P40692 G373S 373 G S 0.022 Neutral MLH1 P40692 G373T 373 G T 0.332 Neutral MLH1 P40692 G373V 373 G V 0.504 Pathogenic MLH1 P40692 G373W 373 G W 0.61 Pathogenic MLH1 P40692 G373Y 373 G Y 0.604 Pathogenic MLH1 P40692 S374A 374 S A 0.01 Neutral MLH1 P40692 S374C 374 S C 0.032 Neutral MLH1 P40692 S374D 374 S D 0.024 Neutral MLH1 P40692 S374E 374 S E 0.138 Neutral MLH1 P40692 S374F 374 S F 0.276 Neutral MLH1 P40692 S374G 374 S G 0.01 Neutral MLH1 P40692 S374H 374 S H 0.238 Neutral MLH1 P40692 S374I 374 S I 0.196 Neutral MLH1 P40692 S374K 374 S K 0.162 Neutral MLH1 P40692 S374L 374 S L 0.068 Neutral MLH1 P40692 S374M 374 S M 0.332 Neutral MLH1 P40692 S374N 374 S N 0 Neutral MLH1 P40692 S374P 374 S P 0.062 Neutral MLH1 P40692 S374Q 374 S Q 0.158 Neutral MLH1 P40692 S374R 374 S R 0.138 Neutral MLH1 P40692 S374T 374 S T 0.02 Neutral MLH1 P40692 S374V 374 S V 0.068 Neutral MLH1 P40692 S374W 374 S W 0.49 Neutral MLH1 P40692 S374Y 374 S Y 0.448 Neutral MLH1 P40692 S375A 375 S A 0.018 Neutral MLH1 P40692 S375C 375 S C 0.022 Neutral MLH1 P40692 S375D 375 S D 0.026 Neutral MLH1 P40692 S375E 375 S E 0.12 Neutral MLH1 P40692 S375F 375 S F 0.28 Neutral MLH1 P40692 S375G 375 S G 0 Neutral MLH1 P40692 S375H 375 S H 0.242 Neutral MLH1 P40692 S375I 375 S I 0.196 Neutral MLH1 P40692 S375K 375 S K 0.146 Neutral MLH1 P40692 S375L 375 S L 0.032 Neutral MLH1 P40692 S375M 375 S M 0.26 Neutral MLH1 P40692 S375N 375 S N 0.034 Neutral MLH1 P40692 S375P 375 S P 0.132 Neutral MLH1 P40692 S375Q 375 S Q 0.162 Neutral MLH1 P40692 S375R 375 S R 0.176 Neutral MLH1 P40692 S375T 375 S T 0.02 Neutral MLH1 P40692 S375V 375 S V 0.138 Neutral MLH1 P40692 S375W 375 S W 0.502 Pathogenic MLH1 P40692 S375Y 375 S Y 0.404 Neutral MLH1 P40692 D376A 376 D A 0.102 Neutral MLH1 P40692 D376C 376 D C 0.168 Neutral MLH1 P40692 D376E 376 D E 0.018 Neutral MLH1 P40692 D376F 376 D F 0.526 Pathogenic MLH1 P40692 D376G 376 D G 0.036 Neutral MLH1 P40692 D376H 376 D H 0.108 Neutral MLH1 P40692 D376I 376 D I 0.32 Neutral MLH1 P40692 D376K 376 D K 0.02 Neutral MLH1 P40692 D376L 376 D L 0.314 Neutral MLH1 P40692 D376M 376 D M 0.234 Neutral MLH1 P40692 D376N 376 D N 0 Neutral MLH1 P40692 D376P 376 D P 0.044 Neutral MLH1 P40692 D376Q 376 D Q 0.014 Neutral MLH1 P40692 D376R 376 D R 0.198 Neutral MLH1 P40692 D376S 376 D S 0.16 Neutral MLH1 P40692 D376T 376 D T 0.172 Neutral MLH1 P40692 D376V 376 D V 0.292 Neutral MLH1 P40692 D376W 376 D W 0.55 Pathogenic MLH1 P40692 D376Y 376 D Y 0.52 Pathogenic MLH1 P40692 K377A 377 K A 0.236 Neutral MLH1 P40692 K377C 377 K C 0.182 Neutral MLH1 P40692 K377D 377 K D 0.236 Neutral MLH1 P40692 K377E 377 K E 0.258 Neutral MLH1 P40692 K377F 377 K F 0.646 Pathogenic MLH1 P40692 K377G 377 K G 0.346 Neutral MLH1 P40692 K377H 377 K H 0.198 Neutral MLH1 P40692 K377I 377 K I 0.68 Pathogenic MLH1 P40692 K377L 377 K L 0.172 Neutral MLH1 P40692 K377M 377 K M 0.57 Pathogenic MLH1 P40692 K377N 377 K N 0.174 Neutral MLH1 P40692 K377P 377 K P 0.094 Neutral MLH1 P40692 K377Q 377 K Q 0.074 Neutral MLH1 P40692 K377R 377 K R 0.032 Neutral MLH1 P40692 K377S 377 K S 0.116 Neutral MLH1 P40692 K377T 377 K T 0.536 Pathogenic MLH1 P40692 K377V 377 K V 0.668 Pathogenic MLH1 P40692 K377W 377 K W 0.874 Pathogenic MLH1 P40692 K377Y 377 K Y 0.814 Pathogenic MLH1 P40692 V378A 378 V A 0.114 Neutral MLH1 P40692 V378C 378 V C 0.17 Neutral MLH1 P40692 V378D 378 V D 0.322 Neutral MLH1 P40692 V378E 378 V E 0.198 Neutral MLH1 P40692 V378F 378 V F 0.45 Neutral MLH1 P40692 V378G 378 V G 0.404 Neutral MLH1 P40692 V378H 378 V H 0.284 Neutral MLH1 P40692 V378I 378 V I 0.01 Neutral MLH1 P40692 V378K 378 V K 0.096 Neutral MLH1 P40692 V378L 378 V L 0.004 Neutral MLH1 P40692 V378M 378 V M 0.21 Neutral MLH1 P40692 V378N 378 V N 0.346 Neutral MLH1 P40692 V378P 378 V P 0.058 Neutral MLH1 P40692 V378Q 378 V Q 0.204 Neutral MLH1 P40692 V378R 378 V R 0.616 Pathogenic MLH1 P40692 V378S 378 V S 0.136 Neutral MLH1 P40692 V378T 378 V T 0.01 Neutral MLH1 P40692 V378W 378 V W 0.62 Pathogenic MLH1 P40692 V378Y 378 V Y 0.306 Neutral MLH1 P40692 Y379A 379 Y A 0.278 Neutral MLH1 P40692 Y379C 379 Y C 0.356 Neutral MLH1 P40692 Y379D 379 Y D 0.118 Neutral MLH1 P40692 Y379E 379 Y E 0.556 Pathogenic MLH1 P40692 Y379F 379 Y F 0.2 Neutral MLH1 P40692 Y379G 379 Y G 0.274 Neutral MLH1 P40692 Y379H 379 Y H 0.054 Neutral MLH1 P40692 Y379I 379 Y I 0.32 Neutral MLH1 P40692 Y379K 379 Y K 0.524 Pathogenic MLH1 P40692 Y379L 379 Y L 0.066 Neutral MLH1 P40692 Y379M 379 Y M 0.31 Neutral MLH1 P40692 Y379N 379 Y N 0.14 Neutral MLH1 P40692 Y379P 379 Y P 0.094 Neutral MLH1 P40692 Y379Q 379 Y Q 0.418 Neutral MLH1 P40692 Y379R 379 Y R 0.098 Neutral MLH1 P40692 Y379S 379 Y S 0.172 Neutral MLH1 P40692 Y379T 379 Y T 0.182 Neutral MLH1 P40692 Y379V 379 Y V 0.448 Neutral MLH1 P40692 Y379W 379 Y W 0.304 Neutral MLH1 P40692 N38A 38 N A 0.74 Pathogenic MLH1 P40692 N38C 38 N C 0.804 Pathogenic MLH1 P40692 N38D 38 N D 0.854 Pathogenic MLH1 P40692 N38E 38 N E 0.74 Pathogenic MLH1 P40692 N38F 38 N F 0.934 Pathogenic MLH1 P40692 N38G 38 N G 0.89 Pathogenic MLH1 P40692 N38H 38 N H 0.948 Pathogenic 5 MLH1 P40692 N38I 38 N I 0.95 Pathogenic MLH1 P40692 N38K 38 N K 0.986 Pathogenic 5 MLH1 P40692 N38L 38 N L 0.968 Pathogenic MLH1 P40692 N38M 38 N M 0.974 Pathogenic MLH1 P40692 N38P 38 N P 0.898 Pathogenic MLH1 P40692 N38Q 38 N Q 0.966 Pathogenic MLH1 P40692 N38R 38 N R 0.924 Pathogenic MLH1 P40692 N38S 38 N S 0.944 Pathogenic 5 MLH1 P40692 N38T 38 N T 0.686 Pathogenic MLH1 P40692 N38V 38 N V 0.992 Pathogenic MLH1 P40692 N38W 38 N W 0.978 Pathogenic MLH1 P40692 N38Y 38 N Y 0.974 Pathogenic MLH1 P40692 A380C 380 A C 0.59 Pathogenic MLH1 P40692 A380D 380 A D 0.59 Pathogenic MLH1 P40692 A380E 380 A E 0.516 Pathogenic MLH1 P40692 A380F 380 A F 0.894 Pathogenic MLH1 P40692 A380G 380 A G 0.11 Neutral MLH1 P40692 A380H 380 A H 0.762 Pathogenic MLH1 P40692 A380I 380 A I 0.832 Pathogenic MLH1 P40692 A380K 380 A K 0.814 Pathogenic MLH1 P40692 A380L 380 A L 0.844 Pathogenic MLH1 P40692 A380M 380 A M 0.724 Pathogenic MLH1 P40692 A380N 380 A N 0.704 Pathogenic MLH1 P40692 A380P 380 A P 0.096 Neutral MLH1 P40692 A380Q 380 A Q 0.738 Pathogenic MLH1 P40692 A380R 380 A R 0.818 Pathogenic MLH1 P40692 A380S 380 A S 0.04 Neutral MLH1 P40692 A380T 380 A T 0.058 Neutral MLH1 P40692 A380V 380 A V 0.098 Neutral MLH1 P40692 A380W 380 A W 0.888 Pathogenic MLH1 P40692 A380Y 380 A Y 0.884 Pathogenic MLH1 P40692 H381A 381 H A 0.294 Neutral MLH1 P40692 H381C 381 H C 0.22 Neutral MLH1 P40692 H381D 381 H D 0.028 Neutral MLH1 P40692 H381E 381 H E 0.274 Neutral MLH1 P40692 H381F 381 H F 0.408 Neutral MLH1 P40692 H381G 381 H G 0.296 Neutral MLH1 P40692 H381I 381 H I 0.734 Pathogenic MLH1 P40692 H381K 381 H K 0.034 Neutral MLH1 P40692 H381L 381 H L 0.7 Pathogenic MLH1 P40692 H381M 381 H M 0.546 Pathogenic MLH1 P40692 H381N 381 H N 0.032 Neutral MLH1 P40692 H381P 381 H P 0.784 Pathogenic MLH1 P40692 H381Q 381 H Q 0.03 Neutral MLH1 P40692 H381R 381 H R 0.018 Neutral MLH1 P40692 H381S 381 H S 0.042 Neutral MLH1 P40692 H381T 381 H T 0.578 Pathogenic MLH1 P40692 H381V 381 H V 0.528 Pathogenic MLH1 P40692 H381W 381 H W 0.896 Pathogenic MLH1 P40692 H381Y 381 H Y 0.062 Neutral MLH1 P40692 Q382A 382 Q A 0.354 Neutral MLH1 P40692 Q382C 382 Q C 0.334 Neutral MLH1 P40692 Q382D 382 Q D 0.02 Neutral MLH1 P40692 Q382E 382 Q E 0.04 Neutral MLH1 P40692 Q382F 382 Q F 0.506 Pathogenic MLH1 P40692 Q382G 382 Q G 0.394 Neutral MLH1 P40692 Q382H 382 Q H 0.062 Neutral MLH1 P40692 Q382I 382 Q I 0.724 Pathogenic MLH1 P40692 Q382K 382 Q K 0.05 Neutral MLH1 P40692 Q382L 382 Q L 0.43 Neutral MLH1 P40692 Q382M 382 Q M 0.656 Pathogenic MLH1 P40692 Q382N 382 Q N 0.058 Neutral MLH1 P40692 Q382P 382 Q P 0.744 Pathogenic MLH1 P40692 Q382R 382 Q R 0.038 Neutral MLH1 P40692 Q382S 382 Q S 0.106 Neutral MLH1 P40692 Q382T 382 Q T 0.536 Pathogenic MLH1 P40692 Q382V 382 Q V 0.72 Pathogenic MLH1 P40692 Q382W 382 Q W 0.848 Pathogenic MLH1 P40692 Q382Y 382 Q Y 0.626 Pathogenic MLH1 P40692 M383A 383 M A 0.3 Neutral MLH1 P40692 M383C 383 M C 0.218 Neutral MLH1 P40692 M383D 383 M D 0.652 Pathogenic MLH1 P40692 M383E 383 M E 0.402 Neutral MLH1 P40692 M383F 383 M F 0.088 Neutral MLH1 P40692 M383G 383 M G 0.346 Neutral MLH1 P40692 M383H 383 M H 0.46 Neutral MLH1 P40692 M383I 383 M I 0.406 Neutral MLH1 P40692 M383K 383 M K 0.088 Neutral MLH1 P40692 M383L 383 M L 0.04 Neutral MLH1 P40692 M383N 383 M N 0.668 Pathogenic MLH1 P40692 M383P 383 M P 0.884 Pathogenic MLH1 P40692 M383Q 383 M Q 0.028 Neutral MLH1 P40692 M383R 383 M R 0.238 Neutral MLH1 P40692 M383S 383 M S 0.184 Neutral MLH1 P40692 M383T 383 M T 0.032 Neutral MLH1 P40692 M383V 383 M V 0.08 Neutral MLH1 P40692 M383W 383 M W 0.96 Pathogenic MLH1 P40692 M383Y 383 M Y 0.854 Pathogenic MLH1 P40692 V384A 384 V A 0.344 Neutral MLH1 P40692 V384C 384 V C 0.71 Pathogenic MLH1 P40692 V384D 384 V D 0.172 Neutral 1 MLH1 P40692 V384E 384 V E 0.978 Pathogenic MLH1 P40692 V384F 384 V F 0.872 Pathogenic MLH1 P40692 V384G 384 V G 0.906 Pathogenic MLH1 P40692 V384H 384 V H 0.812 Pathogenic MLH1 P40692 V384I 384 V I 0.162 Neutral MLH1 P40692 V384K 384 V K 0.976 Pathogenic MLH1 P40692 V384L 384 V L 0.472 Neutral MLH1 P40692 V384M 384 V M 0.81 Pathogenic MLH1 P40692 V384N 384 V N 0.932 Pathogenic MLH1 P40692 V384P 384 V P 0.976 Pathogenic MLH1 P40692 V384Q 384 V Q 0.99 Pathogenic MLH1 P40692 V384R 384 V R 0.958 Pathogenic MLH1 P40692 V384S 384 V S 0.132 Neutral MLH1 P40692 V384T 384 V T 0.292 Neutral MLH1 P40692 V384W 384 V W 0.902 Pathogenic MLH1 P40692 V384Y 384 V Y 0.928 Pathogenic MLH1 P40692 R385A 385 R A 0.49 Neutral MLH1 P40692 R385C 385 R C 0.79 Pathogenic 4 MLH1 P40692 R385D 385 R D 0.722 Pathogenic MLH1 P40692 R385E 385 R E 0.66 Pathogenic MLH1 P40692 R385F 385 R F 0.926 Pathogenic MLH1 P40692 R385G 385 R G 0.102 Neutral MLH1 P40692 R385H 385 R H 0.448 Neutral MLH1 P40692 R385I 385 R I 0.932 Pathogenic MLH1 P40692 R385K 385 R K 0.698 Pathogenic MLH1 P40692 R385L 385 R L 0.912 Pathogenic MLH1 P40692 R385M 385 R M 0.696 Pathogenic MLH1 P40692 R385N 385 R N 0.644 Pathogenic MLH1 P40692 R385P 385 R P 0.662 Pathogenic MLH1 P40692 R385Q 385 R Q 0.534 Pathogenic MLH1 P40692 R385S 385 R S 0.314 Neutral MLH1 P40692 R385T 385 R T 0.734 Pathogenic MLH1 P40692 R385V 385 R V 0.898 Pathogenic MLH1 P40692 R385W 385 R W 0.918 Pathogenic MLH1 P40692 R385Y 385 R Y 0.906 Pathogenic MLH1 P40692 T386A 386 T A 0.392 Neutral MLH1 P40692 T386C 386 T C 0.468 Neutral MLH1 P40692 T386D 386 T D 0.486 Neutral MLH1 P40692 T386E 386 T E 0.428 Neutral MLH1 P40692 T386F 386 T F 0.712 Pathogenic MLH1 P40692 T386G 386 T G 0.19 Neutral MLH1 P40692 T386H 386 T H 0.554 Pathogenic MLH1 P40692 T386I 386 T I 0.526 Pathogenic MLH1 P40692 T386K 386 T K 0.44 Neutral MLH1 P40692 T386L 386 T L 0.526 Pathogenic MLH1 P40692 T386M 386 T M 0.652 Pathogenic MLH1 P40692 T386N 386 T N 0.294 Neutral MLH1 P40692 T386P 386 T P 0.532 Pathogenic MLH1 P40692 T386Q 386 T Q 0.316 Neutral MLH1 P40692 T386R 386 T R 0.79 Pathogenic MLH1 P40692 T386S 386 T S 0.178 Neutral MLH1 P40692 T386V 386 T V 0.126 Neutral MLH1 P40692 T386W 386 T W 0.926 Pathogenic MLH1 P40692 T386Y 386 T Y 0.92 Pathogenic MLH1 P40692 D387A 387 D A 0.502 Pathogenic MLH1 P40692 D387C 387 D C 0.716 Pathogenic MLH1 P40692 D387E 387 D E 0.634 Pathogenic MLH1 P40692 D387F 387 D F 0.92 Pathogenic MLH1 P40692 D387G 387 D G 0.476 Neutral MLH1 P40692 D387H 387 D H 0.432 Neutral MLH1 P40692 D387I 387 D I 0.876 Pathogenic MLH1 P40692 D387K 387 D K 0.72 Pathogenic MLH1 P40692 D387L 387 D L 0.868 Pathogenic MLH1 P40692 D387M 387 D M 0.778 Pathogenic MLH1 P40692 D387N 387 D N 0.118 Neutral MLH1 P40692 D387P 387 D P 0.246 Neutral MLH1 P40692 D387Q 387 D Q 0.468 Neutral MLH1 P40692 D387R 387 D R 0.734 Pathogenic MLH1 P40692 D387S 387 D S 0.032 Neutral MLH1 P40692 D387T 387 D T 0.568 Pathogenic MLH1 P40692 D387V 387 D V 0.902 Pathogenic MLH1 P40692 D387W 387 D W 0.968 Pathogenic MLH1 P40692 D387Y 387 D Y 0.964 Pathogenic MLH1 P40692 S388A 388 S A 0.012 Neutral MLH1 P40692 S388C 388 S C 0.004 Neutral MLH1 P40692 S388D 388 S D 0.15 Neutral MLH1 P40692 S388E 388 S E 0.412 Neutral MLH1 P40692 S388F 388 S F 0.448 Neutral MLH1 P40692 S388G 388 S G 0.16 Neutral MLH1 P40692 S388H 388 S H 0.328 Neutral MLH1 P40692 S388I 388 S I 0.234 Neutral MLH1 P40692 S388K 388 S K 0.446 Neutral MLH1 P40692 S388L 388 S L 0.23 Neutral MLH1 P40692 S388M 388 S M 0.71 Pathogenic MLH1 P40692 S388N 388 S N 0.026 Neutral MLH1 P40692 S388P 388 S P 0.18 Neutral MLH1 P40692 S388Q 388 S Q 0.396 Neutral MLH1 P40692 S388R 388 S R 0.528 Pathogenic MLH1 P40692 S388T 388 S T 0.41 Neutral MLH1 P40692 S388V 388 S V 0.484 Neutral MLH1 P40692 S388W 388 S W 0.83 Pathogenic MLH1 P40692 S388Y 388 S Y 0.794 Pathogenic MLH1 P40692 R389A 389 R A 0.372 Neutral MLH1 P40692 R389C 389 R C 0.608 Pathogenic MLH1 P40692 R389D 389 R D 0.61 Pathogenic MLH1 P40692 R389E 389 R E 0.516 Pathogenic MLH1 P40692 R389F 389 R F 0.788 Pathogenic MLH1 P40692 R389G 389 R G 0.252 Neutral MLH1 P40692 R389H 389 R H 0.526 Pathogenic MLH1 P40692 R389I 389 R I 0.828 Pathogenic MLH1 P40692 R389K 389 R K 0.036 Neutral MLH1 P40692 R389L 389 R L 0.116 Neutral MLH1 P40692 R389M 389 R M 0.62 Pathogenic MLH1 P40692 R389N 389 R N 0.046 Neutral MLH1 P40692 R389P 389 R P 0.122 Neutral MLH1 P40692 R389Q 389 R Q 0.68 Pathogenic MLH1 P40692 R389S 389 R S 0.056 Neutral MLH1 P40692 R389T 389 R T 0.062 Neutral MLH1 P40692 R389V 389 R V 0.746 Pathogenic MLH1 P40692 R389W 389 R W 0.816 Pathogenic MLH1 P40692 R389Y 389 R Y 0.768 Pathogenic MLH1 P40692 C39A 39 C A 0.048 Neutral MLH1 P40692 C39D 39 C D 0.362 Neutral MLH1 P40692 C39E 39 C E 0.618 Pathogenic MLH1 P40692 C39F 39 C F 0.97 Pathogenic 4 MLH1 P40692 C39G 39 C G 0.53 Pathogenic MLH1 P40692 C39H 39 C H 0.756 Pathogenic MLH1 P40692 C39I 39 C I 0.84 Pathogenic MLH1 P40692 C39K 39 C K 0.678 Pathogenic MLH1 P40692 C39L 39 C L 0.836 Pathogenic MLH1 P40692 C39M 39 C M 0.61 Pathogenic MLH1 P40692 C39N 39 C N 0.142 Neutral MLH1 P40692 C39P 39 C P 0.894 Pathogenic MLH1 P40692 C39Q 39 C Q 0.514 Pathogenic MLH1 P40692 C39R 39 C R 0.914 Pathogenic MLH1 P40692 C39S 39 C S 0.17 Neutral MLH1 P40692 C39T 39 C T 0.418 Neutral MLH1 P40692 C39V 39 C V 0.786 Pathogenic MLH1 P40692 C39W 39 C W 0.754 Pathogenic MLH1 P40692 C39Y 39 C Y 0.962 Pathogenic 4 MLH1 P40692 E390A 390 E A 0.152 Neutral MLH1 P40692 E390C 390 E C 0.348 Neutral MLH1 P40692 E390D 390 E D 0.014 Neutral MLH1 P40692 E390F 390 E F 0.76 Pathogenic MLH1 P40692 E390G 390 E G 0.214 Neutral MLH1 P40692 E390H 390 E H 0.492 Neutral MLH1 P40692 E390I 390 E I 0.188 Neutral MLH1 P40692 E390K 390 E K 0.312 Neutral MLH1 P40692 E390L 390 E L 0.1 Neutral MLH1 P40692 E390M 390 E M 0.63 Pathogenic MLH1 P40692 E390N 390 E N 0.206 Neutral MLH1 P40692 E390P 390 E P 0.794 Pathogenic MLH1 P40692 E390Q 390 E Q 0.184 Neutral MLH1 P40692 E390R 390 E R 0.358 Neutral MLH1 P40692 E390S 390 E S 0.04 Neutral MLH1 P40692 E390T 390 E T 0.036 Neutral MLH1 P40692 E390V 390 E V 0.068 Neutral MLH1 P40692 E390W 390 E W 0.892 Pathogenic MLH1 P40692 E390Y 390 E Y 0.802 Pathogenic MLH1 P40692 Q391A 391 Q A 0.54 Pathogenic MLH1 P40692 Q391C 391 Q C 0.494 Neutral MLH1 P40692 Q391D 391 Q D 0.022 Neutral MLH1 P40692 Q391E 391 Q E 0.586 Pathogenic MLH1 P40692 Q391F 391 Q F 0.85 Pathogenic MLH1 P40692 Q391G 391 Q G 0.116 Neutral MLH1 P40692 Q391H 391 Q H 0.812 Pathogenic MLH1 P40692 Q391I 391 Q I 0.852 Pathogenic MLH1 P40692 Q391K 391 Q K 0.788 Pathogenic MLH1 P40692 Q391L 391 Q L 0.45 Neutral MLH1 P40692 Q391M 391 Q M 0.742 Pathogenic MLH1 P40692 Q391N 391 Q N 0.368 Neutral MLH1 P40692 Q391P 391 Q P 0.852 Pathogenic MLH1 P40692 Q391R 391 Q R 0.08 Neutral MLH1 P40692 Q391S 391 Q S 0.158 Neutral MLH1 P40692 Q391T 391 Q T 0.44 Neutral MLH1 P40692 Q391V 391 Q V 0.848 Pathogenic MLH1 P40692 Q391W 391 Q W 0.922 Pathogenic MLH1 P40692 Q391Y 391 Q Y 0.892 Pathogenic MLH1 P40692 K392A 392 K A 0.082 Neutral MLH1 P40692 K392C 392 K C 0.172 Neutral MLH1 P40692 K392D 392 K D 0.162 Neutral MLH1 P40692 K392E 392 K E 0.102 Neutral MLH1 P40692 K392F 392 K F 0.802 Pathogenic MLH1 P40692 K392G 392 K G 0.334 Neutral MLH1 P40692 K392H 392 K H 0.026 Neutral MLH1 P40692 K392I 392 K I 0.852 Pathogenic MLH1 P40692 K392L 392 K L 0.816 Pathogenic MLH1 P40692 K392M 392 K M 0.61 Pathogenic MLH1 P40692 K392N 392 K N 0.174 Neutral MLH1 P40692 K392P 392 K P 0.206 Neutral MLH1 P40692 K392Q 392 K Q 0.346 Neutral MLH1 P40692 K392R 392 K R 0.04 Neutral MLH1 P40692 K392S 392 K S 0.034 Neutral MLH1 P40692 K392T 392 K T 0.038 Neutral MLH1 P40692 K392V 392 K V 0.118 Neutral MLH1 P40692 K392W 392 K W 0.976 Pathogenic MLH1 P40692 K392Y 392 K Y 0.92 Pathogenic MLH1 P40692 L393A 393 L A 0.216 Neutral MLH1 P40692 L393C 393 L C 0.324 Neutral MLH1 P40692 L393D 393 L D 0.116 Neutral MLH1 P40692 L393E 393 L E 0.464 Neutral MLH1 P40692 L393F 393 L F 0.782 Pathogenic MLH1 P40692 L393G 393 L G 0.52 Pathogenic MLH1 P40692 L393H 393 L H 0.174 Neutral MLH1 P40692 L393I 393 L I 0.092 Neutral MLH1 P40692 L393K 393 L K 0.056 Neutral MLH1 P40692 L393M 393 L M 0.044 Neutral MLH1 P40692 L393N 393 L N 0.11 Neutral MLH1 P40692 L393P 393 L P 0.414 Neutral MLH1 P40692 L393Q 393 L Q 0.086 Neutral MLH1 P40692 L393R 393 L R 0.554 Pathogenic MLH1 P40692 L393S 393 L S 0.062 Neutral MLH1 P40692 L393T 393 L T 0.072 Neutral MLH1 P40692 L393V 393 L V 0.422 Neutral MLH1 P40692 L393W 393 L W 0.866 Pathogenic MLH1 P40692 L393Y 393 L Y 0.858 Pathogenic MLH1 P40692 D394A 394 D A 0.096 Neutral MLH1 P40692 D394C 394 D C 0.654 Pathogenic MLH1 P40692 D394E 394 D E 0.026 Neutral MLH1 P40692 D394F 394 D F 0.86 Pathogenic MLH1 P40692 D394G 394 D G 0.482 Neutral MLH1 P40692 D394H 394 D H 0.058 Neutral MLH1 P40692 D394I 394 D I 0.804 Pathogenic MLH1 P40692 D394K 394 D K 0.666 Pathogenic MLH1 P40692 D394L 394 D L 0.094 Neutral MLH1 P40692 D394M 394 D M 0.206 Neutral MLH1 P40692 D394N 394 D N 0.05 Neutral MLH1 P40692 D394P 394 D P 0.414 Neutral MLH1 P40692 D394Q 394 D Q 0.022 Neutral MLH1 P40692 D394R 394 D R 0.612 Pathogenic MLH1 P40692 D394S 394 D S 0.026 Neutral MLH1 P40692 D394T 394 D T 0.338 Neutral MLH1 P40692 D394V 394 D V 0.132 Neutral MLH1 P40692 D394W 394 D W 0.92 Pathogenic MLH1 P40692 D394Y 394 D Y 0.93 Pathogenic MLH1 P40692 A395C 395 A C 0.722 Pathogenic MLH1 P40692 A395D 395 A D 0.69 Pathogenic MLH1 P40692 A395E 395 A E 0.608 Pathogenic MLH1 P40692 A395F 395 A F 0.964 Pathogenic MLH1 P40692 A395G 395 A G 0.476 Neutral MLH1 P40692 A395H 395 A H 0.866 Pathogenic MLH1 P40692 A395I 395 A I 0.684 Pathogenic MLH1 P40692 A395K 395 A K 0.56 Pathogenic MLH1 P40692 A395L 395 A L 0.918 Pathogenic MLH1 P40692 A395M 395 A M 0.832 Pathogenic MLH1 P40692 A395N 395 A N 0.766 Pathogenic MLH1 P40692 A395P 395 A P 0.828 Pathogenic MLH1 P40692 A395Q 395 A Q 0.786 Pathogenic MLH1 P40692 A395R 395 A R 0.652 Pathogenic MLH1 P40692 A395S 395 A S 0.024 Neutral MLH1 P40692 A395T 395 A T 0.046 Neutral MLH1 P40692 A395V 395 A V 0.732 Pathogenic MLH1 P40692 A395W 395 A W 0.95 Pathogenic MLH1 P40692 A395Y 395 A Y 0.94 Pathogenic MLH1 P40692 F396A 396 F A 0.242 Neutral MLH1 P40692 F396C 396 F C 0.292 Neutral MLH1 P40692 F396D 396 F D 0.572 Pathogenic MLH1 P40692 F396E 396 F E 0.662 Pathogenic MLH1 P40692 F396G 396 F G 0.36 Neutral MLH1 P40692 F396H 396 F H 0.334 Neutral MLH1 P40692 F396I 396 F I 0.046 Neutral MLH1 P40692 F396K 396 F K 0.618 Pathogenic MLH1 P40692 F396L 396 F L 0.038 Neutral MLH1 P40692 F396M 396 F M 0.138 Neutral MLH1 P40692 F396N 396 F N 0.56 Pathogenic MLH1 P40692 F396P 396 F P 0.12 Neutral MLH1 P40692 F396Q 396 F Q 0.286 Neutral MLH1 P40692 F396R 396 F R 0.082 Neutral MLH1 P40692 F396S 396 F S 0.104 Neutral MLH1 P40692 F396T 396 F T 0.22 Neutral MLH1 P40692 F396V 396 F V 0.21 Neutral MLH1 P40692 F396W 396 F W 0.866 Pathogenic MLH1 P40692 F396Y 396 F Y 0.048 Neutral MLH1 P40692 L397A 397 L A 0.264 Neutral MLH1 P40692 L397C 397 L C 0.302 Neutral MLH1 P40692 L397D 397 L D 0.114 Neutral MLH1 P40692 L397E 397 L E 0.478 Neutral MLH1 P40692 L397F 397 L F 0.298 Neutral MLH1 P40692 L397G 397 L G 0.538 Pathogenic MLH1 P40692 L397H 397 L H 0.306 Neutral MLH1 P40692 L397I 397 L I 0.382 Neutral MLH1 P40692 L397K 397 L K 0.252 Neutral MLH1 P40692 L397M 397 L M 0.04 Neutral MLH1 P40692 L397N 397 L N 0.116 Neutral MLH1 P40692 L397P 397 L P 0.722 Pathogenic MLH1 P40692 L397Q 397 L Q 0.286 Neutral MLH1 P40692 L397R 397 L R 0.818 Pathogenic MLH1 P40692 L397S 397 L S 0.076 Neutral MLH1 P40692 L397T 397 L T 0.05 Neutral MLH1 P40692 L397V 397 L V 0.028 Neutral MLH1 P40692 L397W 397 L W 0.824 Pathogenic MLH1 P40692 L397Y 397 L Y 0.832 Pathogenic MLH1 P40692 Q398A 398 Q A 0.058 Neutral MLH1 P40692 Q398C 398 Q C 0.19 Neutral MLH1 P40692 Q398D 398 Q D 0.004 Neutral MLH1 P40692 Q398E 398 Q E 0.014 Neutral MLH1 P40692 Q398F 398 Q F 0.61 Pathogenic MLH1 P40692 Q398G 398 Q G 0.176 Neutral MLH1 P40692 Q398H 398 Q H 0.044 Neutral MLH1 P40692 Q398I 398 Q I 0.522 Pathogenic MLH1 P40692 Q398K 398 Q K 0.032 Neutral MLH1 P40692 Q398L 398 Q L 0.134 Neutral MLH1 P40692 Q398M 398 Q M 0.398 Neutral MLH1 P40692 Q398N 398 Q N 0.03 Neutral MLH1 P40692 Q398P 398 Q P 0.27 Neutral MLH1 P40692 Q398R 398 Q R 0.01 Neutral MLH1 P40692 Q398S 398 Q S 0.054 Neutral MLH1 P40692 Q398T 398 Q T 0.006 Neutral MLH1 P40692 Q398V 398 Q V 0.206 Neutral MLH1 P40692 Q398W 398 Q W 0.758 Pathogenic MLH1 P40692 Q398Y 398 Q Y 0.668 Pathogenic MLH1 P40692 P399A 399 P A 0.064 Neutral MLH1 P40692 P399C 399 P C 0.226 Neutral MLH1 P40692 P399D 399 P D 0.014 Neutral MLH1 P40692 P399E 399 P E 0.082 Neutral MLH1 P40692 P399F 399 P F 0.372 Neutral MLH1 P40692 P399G 399 P G 0.132 Neutral MLH1 P40692 P399H 399 P H 0.34 Neutral MLH1 P40692 P399I 399 P I 0.218 Neutral MLH1 P40692 P399K 399 P K 0.078 Neutral MLH1 P40692 P399L 399 P L 0.198 Neutral MLH1 P40692 P399M 399 P M 0.13 Neutral MLH1 P40692 P399N 399 P N 0.1 Neutral MLH1 P40692 P399Q 399 P Q 0.36 Neutral MLH1 P40692 P399R 399 P R 0.434 Neutral MLH1 P40692 P399S 399 P S 0.008 Neutral MLH1 P40692 P399T 399 P T 0.042 Neutral MLH1 P40692 P399V 399 P V 0.054 Neutral MLH1 P40692 P399W 399 P W 0.602 Pathogenic MLH1 P40692 P399Y 399 P Y 0.364 Neutral MLH1 P40692 V4A 4 V A 0.052 Neutral MLH1 P40692 V4C 4 V C 0.06 Neutral MLH1 P40692 V4D 4 V D 0.134 Neutral MLH1 P40692 V4E 4 V E 0.19 Neutral MLH1 P40692 V4F 4 V F 0.192 Neutral MLH1 P40692 V4G 4 V G 0.184 Neutral MLH1 P40692 V4H 4 V H 0.128 Neutral MLH1 P40692 V4I 4 V I 0.04 Neutral MLH1 P40692 V4K 4 V K 0.188 Neutral MLH1 P40692 V4L 4 V L 0.018 Neutral MLH1 P40692 V4M 4 V M 0.014 Neutral MLH1 P40692 V4N 4 V N 0.148 Neutral MLH1 P40692 V4P 4 V P 0.206 Neutral MLH1 P40692 V4Q 4 V Q 0.244 Neutral MLH1 P40692 V4R 4 V R 0.322 Neutral MLH1 P40692 V4S 4 V S 0.092 Neutral MLH1 P40692 V4T 4 V T 0.094 Neutral MLH1 P40692 V4W 4 V W 0.372 Neutral MLH1 P40692 V4Y 4 V Y 0.282 Neutral MLH1 P40692 L40A 40 L A 0.538 Pathogenic MLH1 P40692 L40C 40 L C 0.638 Pathogenic MLH1 P40692 L40D 40 L D 0.542 Pathogenic MLH1 P40692 L40E 40 L E 0.858 Pathogenic MLH1 P40692 L40F 40 L F 0.782 Pathogenic MLH1 P40692 L40G 40 L G 0.804 Pathogenic MLH1 P40692 L40H 40 L H 0.706 Pathogenic MLH1 P40692 L40I 40 L I 0.114 Neutral MLH1 P40692 L40K 40 L K 0.63 Pathogenic MLH1 P40692 L40M 40 L M 0.604 Pathogenic MLH1 P40692 L40N 40 L N 0.778 Pathogenic MLH1 P40692 L40P 40 L P 0.916 Pathogenic MLH1 P40692 L40Q 40 L Q 0.56 Pathogenic MLH1 P40692 L40R 40 L R 0.97 Pathogenic MLH1 P40692 L40S 40 L S 0.546 Pathogenic MLH1 P40692 L40T 40 L T 0.498 Neutral MLH1 P40692 L40V 40 L V 0.086 Neutral MLH1 P40692 L40W 40 L W 0.79 Pathogenic MLH1 P40692 L40Y 40 L Y 0.778 Pathogenic MLH1 P40692 L400A 400 L A 0.008 Neutral MLH1 P40692 L400C 400 L C 0.014 Neutral MLH1 P40692 L400D 400 L D 0.044 Neutral MLH1 P40692 L400E 400 L E 0.154 Neutral MLH1 P40692 L400F 400 L F 0.152 Neutral MLH1 P40692 L400G 400 L G 0.19 Neutral MLH1 P40692 L400H 400 L H 0.084 Neutral MLH1 P40692 L400I 400 L I 0.002 Neutral MLH1 P40692 L400K 400 L K 0.026 Neutral MLH1 P40692 L400M 400 L M 0.01 Neutral MLH1 P40692 L400N 400 L N 0.146 Neutral MLH1 P40692 L400P 400 L P 0.096 Neutral MLH1 P40692 L400Q 400 L Q 0.018 Neutral MLH1 P40692 L400R 400 L R 0.258 Neutral MLH1 P40692 L400S 400 L S 0.014 Neutral MLH1 P40692 L400T 400 L T 0.182 Neutral MLH1 P40692 L400V 400 L V 0 Neutral MLH1 P40692 L400W 400 L W 0.372 Neutral MLH1 P40692 L400Y 400 L Y 0.324 Neutral MLH1 P40692 S401A 401 S A 0.068 Neutral MLH1 P40692 S401C 401 S C 0.022 Neutral MLH1 P40692 S401D 401 S D 0.044 Neutral MLH1 P40692 S401E 401 S E 0.138 Neutral MLH1 P40692 S401F 401 S F 0.276 Neutral MLH1 P40692 S401G 401 S G 0.036 Neutral MLH1 P40692 S401H 401 S H 0.238 Neutral MLH1 P40692 S401I 401 S I 0.196 Neutral MLH1 P40692 S401K 401 S K 0.162 Neutral MLH1 P40692 S401L 401 S L 0.068 Neutral MLH1 P40692 S401M 401 S M 0.332 Neutral MLH1 P40692 S401N 401 S N 0 Neutral MLH1 P40692 S401P 401 S P 0.062 Neutral MLH1 P40692 S401Q 401 S Q 0.158 Neutral MLH1 P40692 S401R 401 S R 0.17 Neutral MLH1 P40692 S401T 401 S T 0.176 Neutral MLH1 P40692 S401V 401 S V 0.248 Neutral MLH1 P40692 S401W 401 S W 0.49 Neutral MLH1 P40692 S401Y 401 S Y 0.448 Neutral MLH1 P40692 K402A 402 K A 0.054 Neutral MLH1 P40692 K402C 402 K C 0.028 Neutral MLH1 P40692 K402D 402 K D 0.066 Neutral MLH1 P40692 K402E 402 K E 0.052 Neutral MLH1 P40692 K402F 402 K F 0.22 Neutral MLH1 P40692 K402G 402 K G 0.132 Neutral MLH1 P40692 K402H 402 K H 0.048 Neutral MLH1 P40692 K402I 402 K I 0.23 Neutral MLH1 P40692 K402L 402 K L 0.222 Neutral MLH1 P40692 K402M 402 K M 0.112 Neutral MLH1 P40692 K402N 402 K N 0.006 Neutral MLH1 P40692 K402P 402 K P 0.01 Neutral MLH1 P40692 K402Q 402 K Q 0.024 Neutral MLH1 P40692 K402R 402 K R 0.002 Neutral MLH1 P40692 K402S 402 K S 0.014 Neutral MLH1 P40692 K402T 402 K T 0.012 Neutral MLH1 P40692 K402V 402 K V 0.186 Neutral MLH1 P40692 K402W 402 K W 0.414 Neutral MLH1 P40692 K402Y 402 K Y 0.344 Neutral MLH1 P40692 P403A 403 P A 0.03 Neutral MLH1 P40692 P403C 403 P C 0.148 Neutral MLH1 P40692 P403D 403 P D 0.078 Neutral MLH1 P40692 P403E 403 P E 0.214 Neutral MLH1 P40692 P403F 403 P F 0.272 Neutral MLH1 P40692 P403G 403 P G 0.01 Neutral MLH1 P40692 P403H 403 P H 0.226 Neutral MLH1 P40692 P403I 403 P I 0.1 Neutral MLH1 P40692 P403K 403 P K 0.206 Neutral MLH1 P40692 P403L 403 P L 0.096 Neutral MLH1 P40692 P403M 403 P M 0.146 Neutral MLH1 P40692 P403N 403 P N 0.068 Neutral MLH1 P40692 P403Q 403 P Q 0.054 Neutral MLH1 P40692 P403R 403 P R 0.202 Neutral MLH1 P40692 P403S 403 P S 0.002 Neutral MLH1 P40692 P403T 403 P T 0.188 Neutral MLH1 P40692 P403V 403 P V 0.044 Neutral MLH1 P40692 P403W 403 P W 0.39 Neutral MLH1 P40692 P403Y 403 P Y 0.32 Neutral MLH1 P40692 L404A 404 L A 0.088 Neutral MLH1 P40692 L404C 404 L C 0.094 Neutral MLH1 P40692 L404D 404 L D 0.038 Neutral MLH1 P40692 L404E 404 L E 0.106 Neutral MLH1 P40692 L404F 404 L F 0.204 Neutral MLH1 P40692 L404G 404 L G 0.08 Neutral MLH1 P40692 L404H 404 L H 0.084 Neutral MLH1 P40692 L404I 404 L I 0.072 Neutral MLH1 P40692 L404K 404 L K 0.116 Neutral MLH1 P40692 L404M 404 L M 0.18 Neutral MLH1 P40692 L404N 404 L N 0.148 Neutral MLH1 P40692 L404P 404 L P 0.088 Neutral MLH1 P40692 L404Q 404 L Q 0.004 Neutral MLH1 P40692 L404R 404 L R 0.28 Neutral MLH1 P40692 L404S 404 L S 0.01 Neutral MLH1 P40692 L404T 404 L T 0.112 Neutral MLH1 P40692 L404V 404 L V 0.016 Neutral MLH1 P40692 L404W 404 L W 0.334 Neutral MLH1 P40692 L404Y 404 L Y 0.284 Neutral MLH1 P40692 S405A 405 S A 0.01 Neutral MLH1 P40692 S405C 405 S C 0.032 Neutral MLH1 P40692 S405D 405 S D 0.044 Neutral MLH1 P40692 S405E 405 S E 0.148 Neutral MLH1 P40692 S405F 405 S F 0.276 Neutral MLH1 P40692 S405G 405 S G 0 Neutral MLH1 P40692 S405H 405 S H 0.17 Neutral MLH1 P40692 S405I 405 S I 0.124 Neutral MLH1 P40692 S405K 405 S K 0.14 Neutral MLH1 P40692 S405L 405 S L 0.026 Neutral MLH1 P40692 S405M 405 S M 0.27 Neutral MLH1 P40692 S405N 405 S N 0.034 Neutral MLH1 P40692 S405P 405 S P 0.056 Neutral MLH1 P40692 S405Q 405 S Q 0.158 Neutral MLH1 P40692 S405R 405 S R 0.248 Neutral MLH1 P40692 S405T 405 S T 0.02 Neutral MLH1 P40692 S405V 405 S V 0.034 Neutral MLH1 P40692 S405W 405 S W 0.49 Neutral MLH1 P40692 S405Y 405 S Y 0.448 Neutral MLH1 P40692 S406A 406 S A 0.01 Neutral MLH1 P40692 S406C 406 S C 0.032 Neutral MLH1 P40692 S406D 406 S D 0.046 Neutral MLH1 P40692 S406E 406 S E 0.136 Neutral MLH1 P40692 S406F 406 S F 0.262 Neutral MLH1 P40692 S406G 406 S G 0.002 Neutral MLH1 P40692 S406H 406 S H 0.178 Neutral MLH1 P40692 S406I 406 S I 0.13 Neutral MLH1 P40692 S406K 406 S K 0.164 Neutral MLH1 P40692 S406L 406 S L 0.074 Neutral MLH1 P40692 S406M 406 S M 0.336 Neutral MLH1 P40692 S406N 406 S N 0.034 Neutral 1 MLH1 P40692 S406P 406 S P 0.098 Neutral MLH1 P40692 S406Q 406 S Q 0.178 Neutral MLH1 P40692 S406R 406 S R 0.198 Neutral MLH1 P40692 S406T 406 S T 0.02 Neutral MLH1 P40692 S406V 406 S V 0.138 Neutral MLH1 P40692 S406W 406 S W 0.53 Pathogenic MLH1 P40692 S406Y 406 S Y 0.486 Neutral MLH1 P40692 Q407A 407 Q A 0.038 Neutral MLH1 P40692 Q407C 407 Q C 0.082 Neutral MLH1 P40692 Q407D 407 Q D 0 Neutral MLH1 P40692 Q407E 407 Q E 0.084 Neutral MLH1 P40692 Q407F 407 Q F 0.362 Neutral MLH1 P40692 Q407G 407 Q G 0.03 Neutral MLH1 P40692 Q407H 407 Q H 0.214 Neutral MLH1 P40692 Q407I 407 Q I 0.354 Neutral MLH1 P40692 Q407K 407 Q K 0.024 Neutral MLH1 P40692 Q407L 407 Q L 0.116 Neutral MLH1 P40692 Q407M 407 Q M 0.186 Neutral MLH1 P40692 Q407N 407 Q N 0.082 Neutral MLH1 P40692 Q407P 407 Q P 0.368 Neutral MLH1 P40692 Q407R 407 Q R 0.002 Neutral MLH1 P40692 Q407S 407 Q S 0.036 Neutral MLH1 P40692 Q407T 407 Q T 0.004 Neutral MLH1 P40692 Q407V 407 Q V 0.26 Neutral MLH1 P40692 Q407W 407 Q W 0.432 Neutral MLH1 P40692 Q407Y 407 Q Y 0.452 Neutral MLH1 P40692 P408A 408 P A 0.04 Neutral MLH1 P40692 P408C 408 P C 0.226 Neutral MLH1 P40692 P408D 408 P D 0.086 Neutral MLH1 P40692 P408E 408 P E 0.302 Neutral MLH1 P40692 P408F 408 P F 0.488 Neutral MLH1 P40692 P408G 408 P G 0.016 Neutral MLH1 P40692 P408H 408 P H 0.416 Neutral MLH1 P40692 P408I 408 P I 0.198 Neutral MLH1 P40692 P408K 408 P K 0.276 Neutral MLH1 P40692 P408L 408 P L 0.184 Neutral MLH1 P40692 P408M 408 P M 0.366 Neutral MLH1 P40692 P408N 408 P N 0.074 Neutral MLH1 P40692 P408Q 408 P Q 0.074 Neutral MLH1 P40692 P408R 408 P R 0.398 Neutral MLH1 P40692 P408S 408 P S 0.008 Neutral MLH1 P40692 P408T 408 P T 0.098 Neutral MLH1 P40692 P408V 408 P V 0.25 Neutral MLH1 P40692 P408W 408 P W 0.586 Pathogenic MLH1 P40692 P408Y 408 P Y 0.52 Pathogenic MLH1 P40692 Q409A 409 Q A 0.138 Neutral MLH1 P40692 Q409C 409 Q C 0.082 Neutral MLH1 P40692 Q409D 409 Q D 0.046 Neutral MLH1 P40692 Q409E 409 Q E 0.008 Neutral MLH1 P40692 Q409F 409 Q F 0.26 Neutral MLH1 P40692 Q409G 409 Q G 0.054 Neutral MLH1 P40692 Q409H 409 Q H 0.034 Neutral MLH1 P40692 Q409I 409 Q I 0.278 Neutral MLH1 P40692 Q409K 409 Q K 0.02 Neutral MLH1 P40692 Q409L 409 Q L 0.146 Neutral MLH1 P40692 Q409M 409 Q M 0.186 Neutral MLH1 P40692 Q409N 409 Q N 0.094 Neutral MLH1 P40692 Q409P 409 Q P 0.218 Neutral MLH1 P40692 Q409R 409 Q R 0.024 Neutral MLH1 P40692 Q409S 409 Q S 0.034 Neutral MLH1 P40692 Q409T 409 Q T 0.064 Neutral MLH1 P40692 Q409V 409 Q V 0.036 Neutral MLH1 P40692 Q409W 409 Q W 0.42 Neutral MLH1 P40692 Q409Y 409 Q Y 0.362 Neutral MLH1 P40692 D41A 41 D A 0.778 Pathogenic MLH1 P40692 D41C 41 D C 0.91 Pathogenic MLH1 P40692 D41E 41 D E 0.946 Pathogenic MLH1 P40692 D41F 41 D F 0.986 Pathogenic MLH1 P40692 D41G 41 D G 0.352 Neutral MLH1 P40692 D41H 41 D H 0.636 Pathogenic 4 MLH1 P40692 D41I 41 D I 0.972 Pathogenic MLH1 P40692 D41K 41 D K 0.982 Pathogenic MLH1 P40692 D41L 41 D L 0.978 Pathogenic MLH1 P40692 D41M 41 D M 0.962 Pathogenic MLH1 P40692 D41N 41 D N 0.842 Pathogenic MLH1 P40692 D41P 41 D P 0.904 Pathogenic MLH1 P40692 D41Q 41 D Q 0.738 Pathogenic MLH1 P40692 D41R 41 D R 0.95 Pathogenic MLH1 P40692 D41S 41 D S 0.248 Neutral MLH1 P40692 D41T 41 D T 0.838 Pathogenic MLH1 P40692 D41V 41 D V 0.992 Pathogenic MLH1 P40692 D41W 41 D W 0.984 Pathogenic MLH1 P40692 D41Y 41 D Y 0.978 Pathogenic MLH1 P40692 A410C 410 A C 0.156 Neutral MLH1 P40692 A410D 410 A D 0.342 Neutral MLH1 P40692 A410E 410 A E 0.302 Neutral MLH1 P40692 A410F 410 A F 0.468 Neutral MLH1 P40692 A410G 410 A G 0.004 Neutral MLH1 P40692 A410H 410 A H 0.304 Neutral MLH1 P40692 A410I 410 A I 0.406 Neutral MLH1 P40692 A410K 410 A K 0.354 Neutral MLH1 P40692 A410L 410 A L 0.4 Neutral MLH1 P40692 A410M 410 A M 0.29 Neutral MLH1 P40692 A410N 410 A N 0.296 Neutral MLH1 P40692 A410P 410 A P 0.3 Neutral MLH1 P40692 A410Q 410 A Q 0.246 Neutral MLH1 P40692 A410R 410 A R 0.286 Neutral MLH1 P40692 A410S 410 A S 0.01 Neutral MLH1 P40692 A410T 410 A T 0.014 Neutral MLH1 P40692 A410V 410 A V 0.136 Neutral MLH1 P40692 A410W 410 A W 0.504 Pathogenic MLH1 P40692 A410Y 410 A Y 0.5 Pathogenic MLH1 P40692 I411A 411 I A 0.006 Neutral MLH1 P40692 I411C 411 I C 0.066 Neutral MLH1 P40692 I411D 411 I D 0.028 Neutral MLH1 P40692 I411E 411 I E 0.028 Neutral MLH1 P40692 I411F 411 I F 0.206 Neutral MLH1 P40692 I411G 411 I G 0.134 Neutral MLH1 P40692 I411H 411 I H 0.014 Neutral MLH1 P40692 I411K 411 I K 0.118 Neutral MLH1 P40692 I411L 411 I L 0.058 Neutral MLH1 P40692 I411M 411 I M 0.018 Neutral MLH1 P40692 I411N 411 I N 0.176 Neutral MLH1 P40692 I411P 411 I P 0.066 Neutral MLH1 P40692 I411Q 411 I Q 0.138 Neutral MLH1 P40692 I411R 411 I R 0.23 Neutral MLH1 P40692 I411S 411 I S 0.072 Neutral MLH1 P40692 I411T 411 I T 0.002 Neutral MLH1 P40692 I411V 411 I V 0 Neutral MLH1 P40692 I411W 411 I W 0.344 Neutral MLH1 P40692 I411Y 411 I Y 0.298 Neutral MLH1 P40692 V412A 412 V A 0 Neutral MLH1 P40692 V412C 412 V C 0.038 Neutral MLH1 P40692 V412D 412 V D 0.028 Neutral MLH1 P40692 V412E 412 V E 0.044 Neutral MLH1 P40692 V412F 412 V F 0.172 Neutral MLH1 P40692 V412G 412 V G 0.04 Neutral MLH1 P40692 V412H 412 V H 0.112 Neutral MLH1 P40692 V412I 412 V I 0.028 Neutral MLH1 P40692 V412K 412 V K 0.158 Neutral MLH1 P40692 V412L 412 V L 0.054 Neutral MLH1 P40692 V412M 412 V M 0.076 Neutral MLH1 P40692 V412N 412 V N 0.138 Neutral MLH1 P40692 V412P 412 V P 0.046 Neutral MLH1 P40692 V412Q 412 V Q 0.216 Neutral MLH1 P40692 V412R 412 V R 0.208 Neutral MLH1 P40692 V412S 412 V S 0.01 Neutral MLH1 P40692 V412T 412 V T 0.008 Neutral MLH1 P40692 V412W 412 V W 0.344 Neutral MLH1 P40692 V412Y 412 V Y 0.256 Neutral MLH1 P40692 T413A 413 T A 0.014 Neutral MLH1 P40692 T413C 413 T C 0.064 Neutral MLH1 P40692 T413D 413 T D 0.058 Neutral MLH1 P40692 T413E 413 T E 0.024 Neutral MLH1 P40692 T413F 413 T F 0.214 Neutral MLH1 P40692 T413G 413 T G 0.002 Neutral MLH1 P40692 T413H 413 T H 0.084 Neutral MLH1 P40692 T413I 413 T I 0.066 Neutral 1 MLH1 P40692 T413K 413 T K 0.032 Neutral MLH1 P40692 T413L 413 T L 0.01 Neutral MLH1 P40692 T413M 413 T M 0.098 Neutral MLH1 P40692 T413N 413 T N 0.02 Neutral MLH1 P40692 T413P 413 T P 0.012 Neutral MLH1 P40692 T413Q 413 T Q 0 Neutral MLH1 P40692 T413R 413 T R 0.156 Neutral MLH1 P40692 T413S 413 T S 0.054 Neutral MLH1 P40692 T413V 413 T V 0.016 Neutral MLH1 P40692 T413W 413 T W 0.466 Neutral MLH1 P40692 T413Y 413 T Y 0.422 Neutral MLH1 P40692 E414A 414 E A 0.068 Neutral MLH1 P40692 E414C 414 E C 0.064 Neutral MLH1 P40692 E414D 414 E D 0 Neutral MLH1 P40692 E414F 414 E F 0.272 Neutral MLH1 P40692 E414G 414 E G 0 Neutral MLH1 P40692 E414H 414 E H 0.104 Neutral MLH1 P40692 E414I 414 E I 0.322 Neutral MLH1 P40692 E414K 414 E K 0.162 Neutral MLH1 P40692 E414L 414 E L 0.286 Neutral MLH1 P40692 E414M 414 E M 0.164 Neutral MLH1 P40692 E414N 414 E N 0.04 Neutral MLH1 P40692 E414P 414 E P 0.3 Neutral MLH1 P40692 E414Q 414 E Q 0 Neutral MLH1 P40692 E414R 414 E R 0.03 Neutral MLH1 P40692 E414S 414 E S 0.018 Neutral MLH1 P40692 E414T 414 E T 0.006 Neutral MLH1 P40692 E414V 414 E V 0.034 Neutral MLH1 P40692 E414W 414 E W 0.43 Neutral MLH1 P40692 E414Y 414 E Y 0.338 Neutral MLH1 P40692 D415A 415 D A 0.014 Neutral MLH1 P40692 D415C 415 D C 0.148 Neutral MLH1 P40692 D415E 415 D E 0.014 Neutral MLH1 P40692 D415F 415 D F 0.37 Neutral MLH1 P40692 D415G 415 D G 0.018 Neutral MLH1 P40692 D415H 415 D H 0.106 Neutral MLH1 P40692 D415I 415 D I 0.262 Neutral MLH1 P40692 D415K 415 D K 0.176 Neutral MLH1 P40692 D415L 415 D L 0.108 Neutral MLH1 P40692 D415M 415 D M 0.19 Neutral MLH1 P40692 D415N 415 D N 0.012 Neutral MLH1 P40692 D415P 415 D P 0.038 Neutral MLH1 P40692 D415Q 415 D Q 0.172 Neutral MLH1 P40692 D415R 415 D R 0.168 Neutral MLH1 P40692 D415S 415 D S 0.002 Neutral MLH1 P40692 D415T 415 D T 0.014 Neutral MLH1 P40692 D415V 415 D V 0.242 Neutral MLH1 P40692 D415W 415 D W 0.434 Neutral MLH1 P40692 D415Y 415 D Y 0.404 Neutral MLH1 P40692 K416A 416 K A 0.028 Neutral MLH1 P40692 K416C 416 K C 0.028 Neutral MLH1 P40692 K416D 416 K D 0.002 Neutral MLH1 P40692 K416E 416 K E 0.004 Neutral MLH1 P40692 K416F 416 K F 0.212 Neutral MLH1 P40692 K416G 416 K G 0.042 Neutral MLH1 P40692 K416H 416 K H 0 Neutral MLH1 P40692 K416I 416 K I 0.19 Neutral MLH1 P40692 K416L 416 K L 0.214 Neutral MLH1 P40692 K416M 416 K M 0.106 Neutral MLH1 P40692 K416N 416 K N 0.006 Neutral MLH1 P40692 K416P 416 K P 0.076 Neutral MLH1 P40692 K416Q 416 K Q 0.01 Neutral MLH1 P40692 K416R 416 K R 0.002 Neutral MLH1 P40692 K416S 416 K S 0.012 Neutral MLH1 P40692 K416T 416 K T 0.012 Neutral MLH1 P40692 K416V 416 K V 0.184 Neutral MLH1 P40692 K416W 416 K W 0.396 Neutral MLH1 P40692 K416Y 416 K Y 0.326 Neutral MLH1 P40692 T417A 417 T A 0 Neutral MLH1 P40692 T417C 417 T C 0.064 Neutral MLH1 P40692 T417D 417 T D 0.02 Neutral MLH1 P40692 T417E 417 T E 0.04 Neutral MLH1 P40692 T417F 417 T F 0.214 Neutral MLH1 P40692 T417G 417 T G 0.056 Neutral MLH1 P40692 T417H 417 T H 0.084 Neutral MLH1 P40692 T417I 417 T I 0.042 Neutral MLH1 P40692 T417K 417 T K 0.042 Neutral MLH1 P40692 T417L 417 T L 0.016 Neutral MLH1 P40692 T417M 417 T M 0.098 Neutral MLH1 P40692 T417N 417 T N 0.002 Neutral MLH1 P40692 T417P 417 T P 0.056 Neutral MLH1 P40692 T417Q 417 T Q 0.01 Neutral MLH1 P40692 T417R 417 T R 0.14 Neutral MLH1 P40692 T417S 417 T S 0 Neutral MLH1 P40692 T417V 417 T V 0.016 Neutral MLH1 P40692 T417W 417 T W 0.466 Neutral MLH1 P40692 T417Y 417 T Y 0.424 Neutral MLH1 P40692 D418A 418 D A 0.072 Neutral MLH1 P40692 D418C 418 D C 0.148 Neutral MLH1 P40692 D418E 418 D E 0.014 Neutral MLH1 P40692 D418F 418 D F 0.37 Neutral MLH1 P40692 D418G 418 D G 0.018 Neutral MLH1 P40692 D418H 418 D H 0.056 Neutral MLH1 P40692 D418I 418 D I 0.14 Neutral MLH1 P40692 D418K 418 D K 0.02 Neutral MLH1 P40692 D418L 418 D L 0.262 Neutral MLH1 P40692 D418M 418 D M 0.19 Neutral MLH1 P40692 D418N 418 D N 0 Neutral MLH1 P40692 D418P 418 D P 0.036 Neutral MLH1 P40692 D418Q 418 D Q 0.014 Neutral MLH1 P40692 D418R 418 D R 0.152 Neutral MLH1 P40692 D418S 418 D S 0.002 Neutral MLH1 P40692 D418T 418 D T 0.012 Neutral MLH1 P40692 D418V 418 D V 0.07 Neutral MLH1 P40692 D418W 418 D W 0.434 Neutral MLH1 P40692 D418Y 418 D Y 0.404 Neutral MLH1 P40692 I419A 419 I A 0.006 Neutral MLH1 P40692 I419C 419 I C 0.09 Neutral MLH1 P40692 I419D 419 I D 0.042 Neutral MLH1 P40692 I419E 419 I E 0.14 Neutral MLH1 P40692 I419F 419 I F 0.206 Neutral MLH1 P40692 I419G 419 I G 0.106 Neutral MLH1 P40692 I419H 419 I H 0.03 Neutral MLH1 P40692 I419K 419 I K 0.166 Neutral MLH1 P40692 I419L 419 I L 0.002 Neutral MLH1 P40692 I419M 419 I M 0.018 Neutral MLH1 P40692 I419N 419 I N 0.096 Neutral MLH1 P40692 I419P 419 I P 0.062 Neutral MLH1 P40692 I419Q 419 I Q 0.096 Neutral MLH1 P40692 I419R 419 I R 0.23 Neutral MLH1 P40692 I419S 419 I S 0.072 Neutral MLH1 P40692 I419T 419 I T 0.004 Neutral MLH1 P40692 I419V 419 I V 0.022 Neutral MLH1 P40692 I419W 419 I W 0.344 Neutral MLH1 P40692 I419Y 419 I Y 0.3 Neutral MLH1 P40692 A42C 42 A C 0.952 Pathogenic MLH1 P40692 A42D 42 A D 0.944 Pathogenic MLH1 P40692 A42E 42 A E 0.952 Pathogenic MLH1 P40692 A42F 42 A F 0.988 Pathogenic MLH1 P40692 A42G 42 A G 0.324 Neutral MLH1 P40692 A42H 42 A H 0.924 Pathogenic MLH1 P40692 A42I 42 A I 0.966 Pathogenic MLH1 P40692 A42K 42 A K 0.966 Pathogenic MLH1 P40692 A42L 42 A L 0.994 Pathogenic MLH1 P40692 A42M 42 A M 0.766 Pathogenic MLH1 P40692 A42N 42 A N 0.862 Pathogenic MLH1 P40692 A42P 42 A P 0.974 Pathogenic MLH1 P40692 A42Q 42 A Q 0.872 Pathogenic MLH1 P40692 A42R 42 A R 0.968 Pathogenic MLH1 P40692 A42S 42 A S 0.282 Neutral MLH1 P40692 A42T 42 A T 0.84 Pathogenic MLH1 P40692 A42V 42 A V 0.934 Pathogenic MLH1 P40692 A42W 42 A W 0.99 Pathogenic MLH1 P40692 A42Y 42 A Y 0.97 Pathogenic MLH1 P40692 S420A 420 S A 0.012 Neutral MLH1 P40692 S420C 420 S C 0.016 Neutral MLH1 P40692 S420D 420 S D 0.008 Neutral MLH1 P40692 S420E 420 S E 0.272 Neutral MLH1 P40692 S420F 420 S F 0.48 Neutral MLH1 P40692 S420G 420 S G 0.004 Neutral MLH1 P40692 S420H 420 S H 0.43 Neutral MLH1 P40692 S420I 420 S I 0.23 Neutral MLH1 P40692 S420K 420 S K 0.358 Neutral MLH1 P40692 S420L 420 S L 0.062 Neutral MLH1 P40692 S420M 420 S M 0.548 Pathogenic MLH1 P40692 S420N 420 S N 0.008 Neutral MLH1 P40692 S420P 420 S P 0.07 Neutral MLH1 P40692 S420Q 420 S Q 0.252 Neutral MLH1 P40692 S420R 420 S R 0.434 Neutral MLH1 P40692 S420T 420 S T 0.028 Neutral MLH1 P40692 S420V 420 S V 0.394 Neutral MLH1 P40692 S420W 420 S W 0.728 Pathogenic MLH1 P40692 S420Y 420 S Y 0.688 Pathogenic MLH1 P40692 S421A 421 S A 0.012 Neutral MLH1 P40692 S421C 421 S C 0.032 Neutral MLH1 P40692 S421D 421 S D 0.002 Neutral MLH1 P40692 S421E 421 S E 0.138 Neutral MLH1 P40692 S421F 421 S F 0.276 Neutral MLH1 P40692 S421G 421 S G 0.002 Neutral MLH1 P40692 S421H 421 S H 0.172 Neutral MLH1 P40692 S421I 421 S I 0.196 Neutral MLH1 P40692 S421K 421 S K 0.148 Neutral MLH1 P40692 S421L 421 S L 0.028 Neutral MLH1 P40692 S421M 421 S M 0.332 Neutral MLH1 P40692 S421N 421 S N 0 Neutral MLH1 P40692 S421P 421 S P 0.064 Neutral MLH1 P40692 S421Q 421 S Q 0.19 Neutral MLH1 P40692 S421R 421 S R 0.156 Neutral MLH1 P40692 S421T 421 S T 0.024 Neutral MLH1 P40692 S421V 421 S V 0.134 Neutral MLH1 P40692 S421W 421 S W 0.49 Neutral MLH1 P40692 S421Y 421 S Y 0.386 Neutral MLH1 P40692 G422A 422 G A 0.002 Neutral MLH1 P40692 G422C 422 G C 0.168 Neutral MLH1 P40692 G422D 422 G D 0.12 Neutral MLH1 P40692 G422E 422 G E 0.188 Neutral MLH1 P40692 G422F 422 G F 0.478 Neutral MLH1 P40692 G422H 422 G H 0.28 Neutral MLH1 P40692 G422I 422 G I 0.408 Neutral MLH1 P40692 G422K 422 G K 0.312 Neutral MLH1 P40692 G422L 422 G L 0.316 Neutral MLH1 P40692 G422M 422 G M 0.28 Neutral MLH1 P40692 G422N 422 G N 0.162 Neutral MLH1 P40692 G422P 422 G P 0.368 Neutral MLH1 P40692 G422Q 422 G Q 0.206 Neutral MLH1 P40692 G422R 422 G R 0.306 Neutral MLH1 P40692 G422S 422 G S 0.014 Neutral MLH1 P40692 G422T 422 G T 0.274 Neutral MLH1 P40692 G422V 422 G V 0.304 Neutral MLH1 P40692 G422W 422 G W 0.488 Neutral MLH1 P40692 G422Y 422 G Y 0.424 Neutral MLH1 P40692 R423A 423 R A 0.038 Neutral MLH1 P40692 R423C 423 R C 0.14 Neutral MLH1 P40692 R423D 423 R D 0.018 Neutral MLH1 P40692 R423E 423 R E 0.022 Neutral MLH1 P40692 R423F 423 R F 0.034 Neutral MLH1 P40692 R423G 423 R G 0.002 Neutral MLH1 P40692 R423H 423 R H 0.12 Neutral MLH1 P40692 R423I 423 R I 0.116 Neutral MLH1 P40692 R423K 423 R K 0.004 Neutral MLH1 P40692 R423L 423 R L 0.012 Neutral MLH1 P40692 R423M 423 R M 0.066 Neutral MLH1 P40692 R423N 423 R N 0.01 Neutral MLH1 P40692 R423P 423 R P 0.028 Neutral MLH1 P40692 R423Q 423 R Q 0.028 Neutral MLH1 P40692 R423S 423 R S 0.016 Neutral MLH1 P40692 R423T 423 R T 0.016 Neutral MLH1 P40692 R423V 423 R V 0.03 Neutral MLH1 P40692 R423W 423 R W 0.384 Neutral MLH1 P40692 R423Y 423 R Y 0.284 Neutral MLH1 P40692 A424C 424 A C 0.182 Neutral MLH1 P40692 A424D 424 A D 0.348 Neutral MLH1 P40692 A424E 424 A E 0.29 Neutral MLH1 P40692 A424F 424 A F 0.292 Neutral MLH1 P40692 A424G 424 A G 0.004 Neutral MLH1 P40692 A424H 424 A H 0.26 Neutral MLH1 P40692 A424I 424 A I 0.396 Neutral MLH1 P40692 A424K 424 A K 0.268 Neutral MLH1 P40692 A424L 424 A L 0.354 Neutral MLH1 P40692 A424M 424 A M 0.226 Neutral MLH1 P40692 A424N 424 A N 0.314 Neutral MLH1 P40692 A424P 424 A P 0.036 Neutral MLH1 P40692 A424Q 424 A Q 0.26 Neutral MLH1 P40692 A424R 424 A R 0.318 Neutral MLH1 P40692 A424S 424 A S 0.004 Neutral MLH1 P40692 A424T 424 A T 0.014 Neutral MLH1 P40692 A424V 424 A V 0.04 Neutral MLH1 P40692 A424W 424 A W 0.504 Pathogenic MLH1 P40692 A424Y 424 A Y 0.5 Pathogenic MLH1 P40692 R425A 425 R A 0.126 Neutral MLH1 P40692 R425C 425 R C 0.074 Neutral MLH1 P40692 R425D 425 R D 0.018 Neutral MLH1 P40692 R425E 425 R E 0.022 Neutral MLH1 P40692 R425F 425 R F 0.28 Neutral MLH1 P40692 R425G 425 R G 0.002 Neutral MLH1 P40692 R425H 425 R H 0.142 Neutral MLH1 P40692 R425I 425 R I 0.304 Neutral MLH1 P40692 R425K 425 R K 0.168 Neutral MLH1 P40692 R425L 425 R L 0.272 Neutral MLH1 P40692 R425M 425 R M 0.15 Neutral MLH1 P40692 R425N 425 R N 0.016 Neutral MLH1 P40692 R425P 425 R P 0.028 Neutral MLH1 P40692 R425Q 425 R Q 0.116 Neutral MLH1 P40692 R425S 425 R S 0.164 Neutral MLH1 P40692 R425T 425 R T 0.066 Neutral MLH1 P40692 R425V 425 R V 0.094 Neutral MLH1 P40692 R425W 425 R W 0.448 Neutral MLH1 P40692 R425Y 425 R Y 0.284 Neutral MLH1 P40692 Q426A 426 Q A 0.076 Neutral MLH1 P40692 Q426C 426 Q C 0.082 Neutral MLH1 P40692 Q426D 426 Q D 0 Neutral MLH1 P40692 Q426E 426 Q E 0.12 Neutral MLH1 P40692 Q426F 426 Q F 0.26 Neutral MLH1 P40692 Q426G 426 Q G 0.03 Neutral MLH1 P40692 Q426H 426 Q H 0.214 Neutral MLH1 P40692 Q426I 426 Q I 0.278 Neutral MLH1 P40692 Q426K 426 Q K 0.21 Neutral MLH1 P40692 Q426L 426 Q L 0.118 Neutral MLH1 P40692 Q426M 426 Q M 0.022 Neutral MLH1 P40692 Q426N 426 Q N 0.064 Neutral MLH1 P40692 Q426P 426 Q P 0.218 Neutral MLH1 P40692 Q426R 426 Q R 0.004 Neutral MLH1 P40692 Q426S 426 Q S 0.034 Neutral MLH1 P40692 Q426T 426 Q T 0.002 Neutral MLH1 P40692 Q426V 426 Q V 0.01 Neutral MLH1 P40692 Q426W 426 Q W 0.42 Neutral MLH1 P40692 Q426Y 426 Q Y 0.362 Neutral MLH1 P40692 Q427A 427 Q A 0.036 Neutral MLH1 P40692 Q427C 427 Q C 0.048 Neutral MLH1 P40692 Q427D 427 Q D 0 Neutral MLH1 P40692 Q427E 427 Q E 0.008 Neutral MLH1 P40692 Q427F 427 Q F 0.26 Neutral MLH1 P40692 Q427G 427 Q G 0.054 Neutral MLH1 P40692 Q427H 427 Q H 0.214 Neutral MLH1 P40692 Q427I 427 Q I 0.278 Neutral MLH1 P40692 Q427K 427 Q K 0.02 Neutral MLH1 P40692 Q427L 427 Q L 0.214 Neutral MLH1 P40692 Q427M 427 Q M 0.022 Neutral MLH1 P40692 Q427N 427 Q N 0.018 Neutral MLH1 P40692 Q427P 427 Q P 0.368 Neutral MLH1 P40692 Q427R 427 Q R 0.022 Neutral MLH1 P40692 Q427S 427 Q S 0.034 Neutral MLH1 P40692 Q427T 427 Q T 0.002 Neutral MLH1 P40692 Q427V 427 Q V 0.268 Neutral MLH1 P40692 Q427W 427 Q W 0.42 Neutral MLH1 P40692 Q427Y 427 Q Y 0.378 Neutral MLH1 P40692 D428A 428 D A 0.024 Neutral MLH1 P40692 D428C 428 D C 0.252 Neutral MLH1 P40692 D428E 428 D E 0.02 Neutral MLH1 P40692 D428F 428 D F 0.612 Pathogenic MLH1 P40692 D428G 428 D G 0.098 Neutral MLH1 P40692 D428H 428 D H 0.142 Neutral MLH1 P40692 D428I 428 D I 0.462 Neutral MLH1 P40692 D428K 428 D K 0.294 Neutral MLH1 P40692 D428L 428 D L 0.17 Neutral MLH1 P40692 D428M 428 D M 0.324 Neutral MLH1 P40692 D428N 428 D N 0.002 Neutral MLH1 P40692 D428P 428 D P 0.434 Neutral MLH1 P40692 D428Q 428 D Q 0.092 Neutral MLH1 P40692 D428R 428 D R 0.254 Neutral MLH1 P40692 D428S 428 D S 0.008 Neutral MLH1 P40692 D428T 428 D T 0.026 Neutral MLH1 P40692 D428V 428 D V 0.414 Neutral MLH1 P40692 D428W 428 D W 0.696 Pathogenic MLH1 P40692 D428Y 428 D Y 0.67 Pathogenic MLH1 P40692 E429A 429 E A 0.066 Neutral MLH1 P40692 E429C 429 E C 0.064 Neutral MLH1 P40692 E429D 429 E D 0.038 Neutral MLH1 P40692 E429F 429 E F 0.312 Neutral MLH1 P40692 E429G 429 E G 0 Neutral MLH1 P40692 E429H 429 E H 0.016 Neutral MLH1 P40692 E429I 429 E I 0.284 Neutral MLH1 P40692 E429K 429 E K 0.002 Neutral MLH1 P40692 E429L 429 E L 0.04 Neutral MLH1 P40692 E429M 429 E M 0.018 Neutral MLH1 P40692 E429N 429 E N 0.036 Neutral MLH1 P40692 E429P 429 E P 0.042 Neutral MLH1 P40692 E429Q 429 E Q 0 Neutral MLH1 P40692 E429R 429 E R 0.03 Neutral MLH1 P40692 E429S 429 E S 0.014 Neutral MLH1 P40692 E429T 429 E T 0.006 Neutral MLH1 P40692 E429V 429 E V 0.034 Neutral MLH1 P40692 E429W 429 E W 0.43 Neutral MLH1 P40692 E429Y 429 E Y 0.338 Neutral MLH1 P40692 K43A 43 K A 0.158 Neutral MLH1 P40692 K43C 43 K C 0.21 Neutral MLH1 P40692 K43D 43 K D 0.138 Neutral MLH1 P40692 K43E 43 K E 0.08 Neutral MLH1 P40692 K43F 43 K F 0.86 Pathogenic MLH1 P40692 K43G 43 K G 0.196 Neutral MLH1 P40692 K43H 43 K H 0.02 Neutral MLH1 P40692 K43I 43 K I 0.902 Pathogenic MLH1 P40692 K43L 43 K L 0.866 Pathogenic MLH1 P40692 K43M 43 K M 0.658 Pathogenic MLH1 P40692 K43N 43 K N 0.028 Neutral MLH1 P40692 K43P 43 K P 0.834 Pathogenic MLH1 P40692 K43Q 43 K Q 0.034 Neutral MLH1 P40692 K43R 43 K R 0.088 Neutral MLH1 P40692 K43S 43 K S 0.39 Neutral MLH1 P40692 K43T 43 K T 0.314 Neutral MLH1 P40692 K43V 43 K V 0.782 Pathogenic MLH1 P40692 K43W 43 K W 0.972 Pathogenic MLH1 P40692 K43Y 43 K Y 0.932 Pathogenic MLH1 P40692 E430A 430 E A 0.076 Neutral MLH1 P40692 E430C 430 E C 0.126 Neutral MLH1 P40692 E430D 430 E D 0.002 Neutral MLH1 P40692 E430F 430 E F 0.088 Neutral MLH1 P40692 E430G 430 E G 0.004 Neutral MLH1 P40692 E430H 430 E H 0.246 Neutral MLH1 P40692 E430I 430 E I 0.204 Neutral MLH1 P40692 E430K 430 E K 0.102 Neutral MLH1 P40692 E430L 430 E L 0.062 Neutral MLH1 P40692 E430M 430 E M 0.02 Neutral MLH1 P40692 E430N 430 E N 0.092 Neutral MLH1 P40692 E430P 430 E P 0.062 Neutral MLH1 P40692 E430Q 430 E Q 0.02 Neutral MLH1 P40692 E430R 430 E R 0.034 Neutral MLH1 P40692 E430S 430 E S 0.016 Neutral MLH1 P40692 E430T 430 E T 0.016 Neutral MLH1 P40692 E430V 430 E V 0.042 Neutral MLH1 P40692 E430W 430 E W 0.708 Pathogenic MLH1 P40692 E430Y 430 E Y 0.594 Pathogenic MLH1 P40692 M431A 431 M A 0.054 Neutral MLH1 P40692 M431C 431 M C 0.048 Neutral MLH1 P40692 M431D 431 M D 0.07 Neutral MLH1 P40692 M431E 431 M E 0.016 Neutral MLH1 P40692 M431F 431 M F 0.042 Neutral MLH1 P40692 M431G 431 M G 0.128 Neutral MLH1 P40692 M431H 431 M H 0.05 Neutral MLH1 P40692 M431I 431 M I 0.018 Neutral MLH1 P40692 M431K 431 M K 0.03 Neutral MLH1 P40692 M431L 431 M L 0.012 Neutral MLH1 P40692 M431N 431 M N 0.09 Neutral MLH1 P40692 M431P 431 M P 0.052 Neutral MLH1 P40692 M431Q 431 M Q 0.062 Neutral MLH1 P40692 M431R 431 M R 0.066 Neutral MLH1 P40692 M431S 431 M S 0.018 Neutral MLH1 P40692 M431T 431 M T 0.014 Neutral MLH1 P40692 M431V 431 M V 0.032 Neutral MLH1 P40692 M431W 431 M W 0.666 Pathogenic MLH1 P40692 M431Y 431 M Y 0.574 Pathogenic MLH1 P40692 L432A 432 L A 0.008 Neutral MLH1 P40692 L432C 432 L C 0.094 Neutral MLH1 P40692 L432D 432 L D 0.04 Neutral MLH1 P40692 L432E 432 L E 0.03 Neutral MLH1 P40692 L432F 432 L F 0.214 Neutral MLH1 P40692 L432G 432 L G 0.052 Neutral MLH1 P40692 L432H 432 L H 0.024 Neutral MLH1 P40692 L432I 432 L I 0.03 Neutral MLH1 P40692 L432K 432 L K 0.018 Neutral MLH1 P40692 L432M 432 L M 0.132 Neutral MLH1 P40692 L432N 432 L N 0.028 Neutral MLH1 P40692 L432P 432 L P 0.088 Neutral MLH1 P40692 L432Q 432 L Q 0.004 Neutral MLH1 P40692 L432R 432 L R 0.244 Neutral MLH1 P40692 L432S 432 L S 0.01 Neutral MLH1 P40692 L432T 432 L T 0.012 Neutral MLH1 P40692 L432V 432 L V 0 Neutral MLH1 P40692 L432W 432 L W 0.344 Neutral MLH1 P40692 L432Y 432 L Y 0.298 Neutral MLH1 P40692 E433A 433 E A 0.078 Neutral MLH1 P40692 E433C 433 E C 0.118 Neutral MLH1 P40692 E433D 433 E D 0.004 Neutral MLH1 P40692 E433F 433 E F 0.422 Neutral MLH1 P40692 E433G 433 E G 0.006 Neutral MLH1 P40692 E433H 433 E H 0.17 Neutral MLH1 P40692 E433I 433 E I 0.152 Neutral MLH1 P40692 E433K 433 E K 0.006 Neutral MLH1 P40692 E433L 433 E L 0.206 Neutral MLH1 P40692 E433M 433 E M 0.282 Neutral MLH1 P40692 E433N 433 E N 0.048 Neutral MLH1 P40692 E433P 433 E P 0.066 Neutral MLH1 P40692 E433Q 433 E Q 0.002 Neutral MLH1 P40692 E433R 433 E R 0.026 Neutral MLH1 P40692 E433S 433 E S 0.02 Neutral MLH1 P40692 E433T 433 E T 0.016 Neutral MLH1 P40692 E433V 433 E V 0.062 Neutral MLH1 P40692 E433W 433 E W 0.696 Pathogenic MLH1 P40692 E433Y 433 E Y 0.646 Pathogenic MLH1 P40692 L434A 434 L A 0.008 Neutral MLH1 P40692 L434C 434 L C 0.094 Neutral MLH1 P40692 L434D 434 L D 0.036 Neutral MLH1 P40692 L434E 434 L E 0.03 Neutral MLH1 P40692 L434F 434 L F 0.214 Neutral MLH1 P40692 L434G 434 L G 0.188 Neutral MLH1 P40692 L434H 434 L H 0.024 Neutral MLH1 P40692 L434I 434 L I 0.002 Neutral MLH1 P40692 L434K 434 L K 0.086 Neutral MLH1 P40692 L434M 434 L M 0.08 Neutral MLH1 P40692 L434N 434 L N 0.03 Neutral MLH1 P40692 L434P 434 L P 0.088 Neutral MLH1 P40692 L434Q 434 L Q 0.004 Neutral MLH1 P40692 L434R 434 L R 0.294 Neutral MLH1 P40692 L434S 434 L S 0.01 Neutral MLH1 P40692 L434T 434 L T 0.012 Neutral MLH1 P40692 L434V 434 L V 0 Neutral MLH1 P40692 L434W 434 L W 0.344 Neutral MLH1 P40692 L434Y 434 L Y 0.298 Neutral MLH1 P40692 P435A 435 P A 0.032 Neutral MLH1 P40692 P435C 435 P C 0.126 Neutral MLH1 P40692 P435D 435 P D 0.008 Neutral MLH1 P40692 P435E 435 P E 0.054 Neutral MLH1 P40692 P435F 435 P F 0.268 Neutral MLH1 P40692 P435G 435 P G 0.066 Neutral MLH1 P40692 P435H 435 P H 0.226 Neutral MLH1 P40692 P435I 435 P I 0.042 Neutral MLH1 P40692 P435K 435 P K 0.05 Neutral MLH1 P40692 P435L 435 P L 0.042 Neutral MLH1 P40692 P435M 435 P M 0.084 Neutral MLH1 P40692 P435N 435 P N 0.004 Neutral MLH1 P40692 P435Q 435 P Q 0.15 Neutral MLH1 P40692 P435R 435 P R 0.204 Neutral MLH1 P40692 P435S 435 P S 0.002 Neutral MLH1 P40692 P435T 435 P T 0.012 Neutral MLH1 P40692 P435V 435 P V 0.044 Neutral MLH1 P40692 P435W 435 P W 0.39 Neutral MLH1 P40692 P435Y 435 P Y 0.27 Neutral MLH1 P40692 A436C 436 A C 0.212 Neutral MLH1 P40692 A436D 436 A D 0.346 Neutral MLH1 P40692 A436E 436 A E 0.286 Neutral MLH1 P40692 A436F 436 A F 0.408 Neutral MLH1 P40692 A436G 436 A G 0.004 Neutral MLH1 P40692 A436H 436 A H 0.234 Neutral MLH1 P40692 A436I 436 A I 0.334 Neutral MLH1 P40692 A436K 436 A K 0.268 Neutral MLH1 P40692 A436L 436 A L 0.3 Neutral MLH1 P40692 A436M 436 A M 0.228 Neutral MLH1 P40692 A436N 436 A N 0.292 Neutral MLH1 P40692 A436P 436 A P 0.038 Neutral MLH1 P40692 A436Q 436 A Q 0.264 Neutral MLH1 P40692 A436R 436 A R 0.3 Neutral MLH1 P40692 A436S 436 A S 0.006 Neutral MLH1 P40692 A436T 436 A T 0.018 Neutral MLH1 P40692 A436V 436 A V 0.04 Neutral MLH1 P40692 A436W 436 A W 0.504 Pathogenic MLH1 P40692 A436Y 436 A Y 0.5 Pathogenic MLH1 P40692 P437A 437 P A 0.034 Neutral MLH1 P40692 P437C 437 P C 0.164 Neutral MLH1 P40692 P437D 437 P D 0.01 Neutral MLH1 P40692 P437E 437 P E 0.062 Neutral MLH1 P40692 P437F 437 P F 0.284 Neutral MLH1 P40692 P437G 437 P G 0.01 Neutral MLH1 P40692 P437H 437 P H 0.266 Neutral MLH1 P40692 P437I 437 P I 0.064 Neutral MLH1 P40692 P437K 437 P K 0.062 Neutral MLH1 P40692 P437L 437 P L 0.048 Neutral MLH1 P40692 P437M 437 P M 0.218 Neutral MLH1 P40692 P437N 437 P N 0.008 Neutral MLH1 P40692 P437Q 437 P Q 0.182 Neutral MLH1 P40692 P437R 437 P R 0.24 Neutral MLH1 P40692 P437S 437 P S 0.002 Neutral MLH1 P40692 P437T 437 P T 0.012 Neutral MLH1 P40692 P437V 437 P V 0.044 Neutral MLH1 P40692 P437W 437 P W 0.45 Neutral MLH1 P40692 P437Y 437 P Y 0.376 Neutral MLH1 P40692 A438C 438 A C 0.182 Neutral MLH1 P40692 A438D 438 A D 0.346 Neutral MLH1 P40692 A438E 438 A E 0.288 Neutral MLH1 P40692 A438F 438 A F 0.296 Neutral MLH1 P40692 A438G 438 A G 0.006 Neutral MLH1 P40692 A438H 438 A H 0.238 Neutral MLH1 P40692 A438I 438 A I 0.36 Neutral MLH1 P40692 A438K 438 A K 0.272 Neutral MLH1 P40692 A438L 438 A L 0.314 Neutral MLH1 P40692 A438M 438 A M 0.266 Neutral MLH1 P40692 A438N 438 A N 0.306 Neutral MLH1 P40692 A438P 438 A P 0.036 Neutral MLH1 P40692 A438Q 438 A Q 0.252 Neutral MLH1 P40692 A438R 438 A R 0.302 Neutral MLH1 P40692 A438S 438 A S 0.006 Neutral MLH1 P40692 A438T 438 A T 0.012 Neutral MLH1 P40692 A438V 438 A V 0.05 Neutral MLH1 P40692 A438W 438 A W 0.504 Pathogenic MLH1 P40692 A438Y 438 A Y 0.5 Pathogenic MLH1 P40692 E439A 439 E A 0.068 Neutral MLH1 P40692 E439C 439 E C 0.084 Neutral MLH1 P40692 E439D 439 E D 0.002 Neutral MLH1 P40692 E439F 439 E F 0.354 Neutral MLH1 P40692 E439G 439 E G 0.002 Neutral MLH1 P40692 E439H 439 E H 0.136 Neutral MLH1 P40692 E439I 439 E I 0.398 Neutral MLH1 P40692 E439K 439 E K 0.004 Neutral MLH1 P40692 E439L 439 E L 0.052 Neutral MLH1 P40692 E439M 439 E M 0.206 Neutral MLH1 P40692 E439N 439 E N 0.004 Neutral MLH1 P40692 E439P 439 E P 0.056 Neutral MLH1 P40692 E439Q 439 E Q 0.002 Neutral MLH1 P40692 E439R 439 E R 0.02 Neutral MLH1 P40692 E439S 439 E S 0.022 Neutral MLH1 P40692 E439T 439 E T 0.01 Neutral MLH1 P40692 E439V 439 E V 0.082 Neutral MLH1 P40692 E439W 439 E W 0.618 Pathogenic MLH1 P40692 E439Y 439 E Y 0.496 Neutral MLH1 P40692 S44A 44 S A 0.11 Neutral 1 MLH1 P40692 S44C 44 S C 0.226 Neutral MLH1 P40692 S44D 44 S D 0.74 Pathogenic MLH1 P40692 S44E 44 S E 0.874 Pathogenic MLH1 P40692 S44F 44 S F 0.966 Pathogenic 5 MLH1 P40692 S44G 44 S G 0.138 Neutral MLH1 P40692 S44H 44 S H 0.904 Pathogenic MLH1 P40692 S44I 44 S I 0.802 Pathogenic MLH1 P40692 S44K 44 S K 0.862 Pathogenic MLH1 P40692 S44L 44 S L 0.828 Pathogenic MLH1 P40692 S44M 44 S M 0.986 Pathogenic MLH1 P40692 S44N 44 S N 0.706 Pathogenic MLH1 P40692 S44P 44 S P 0.848 Pathogenic MLH1 P40692 S44Q 44 S Q 0.83 Pathogenic MLH1 P40692 S44R 44 S R 0.914 Pathogenic MLH1 P40692 S44T 44 S T 0.668 Pathogenic MLH1 P40692 S44V 44 S V 0.854 Pathogenic MLH1 P40692 S44W 44 S W 0.932 Pathogenic MLH1 P40692 S44Y 44 S Y 0.93 Pathogenic MLH1 P40692 V440A 440 V A 0 Neutral MLH1 P40692 V440C 440 V C 0.016 Neutral MLH1 P40692 V440D 440 V D 0.028 Neutral MLH1 P40692 V440E 440 V E 0.044 Neutral MLH1 P40692 V440F 440 V F 0.142 Neutral MLH1 P40692 V440G 440 V G 0.038 Neutral MLH1 P40692 V440H 440 V H 0.048 Neutral MLH1 P40692 V440I 440 V I 0.002 Neutral MLH1 P40692 V440K 440 V K 0.064 Neutral MLH1 P40692 V440L 440 V L 0.004 Neutral MLH1 P40692 V440M 440 V M 0.014 Neutral MLH1 P40692 V440N 440 V N 0.038 Neutral MLH1 P40692 V440P 440 V P 0.036 Neutral MLH1 P40692 V440Q 440 V Q 0.05 Neutral MLH1 P40692 V440R 440 V R 0.21 Neutral MLH1 P40692 V440S 440 V S 0.01 Neutral MLH1 P40692 V440T 440 V T 0.008 Neutral MLH1 P40692 V440W 440 V W 0.344 Neutral MLH1 P40692 V440Y 440 V Y 0.256 Neutral MLH1 P40692 A441C 441 A C 0.072 Neutral MLH1 P40692 A441D 441 A D 0.344 Neutral MLH1 P40692 A441E 441 A E 0.288 Neutral MLH1 P40692 A441F 441 A F 0.408 Neutral MLH1 P40692 A441G 441 A G 0.004 Neutral MLH1 P40692 A441H 441 A H 0.26 Neutral MLH1 P40692 A441I 441 A I 0.334 Neutral MLH1 P40692 A441K 441 A K 0.262 Neutral MLH1 P40692 A441L 441 A L 0.318 Neutral MLH1 P40692 A441M 441 A M 0.24 Neutral MLH1 P40692 A441N 441 A N 0.31 Neutral MLH1 P40692 A441P 441 A P 0.036 Neutral MLH1 P40692 A441Q 441 A Q 0.286 Neutral MLH1 P40692 A441R 441 A R 0.326 Neutral MLH1 P40692 A441S 441 A S 0.006 Neutral MLH1 P40692 A441T 441 A T 0.012 Neutral MLH1 P40692 A441V 441 A V 0.044 Neutral MLH1 P40692 A441W 441 A W 0.504 Pathogenic MLH1 P40692 A441Y 441 A Y 0.482 Neutral MLH1 P40692 A442C 442 A C 0.192 Neutral MLH1 P40692 A442D 442 A D 0.35 Neutral MLH1 P40692 A442E 442 A E 0.292 Neutral MLH1 P40692 A442F 442 A F 0.48 Neutral MLH1 P40692 A442G 442 A G 0.004 Neutral MLH1 P40692 A442H 442 A H 0.27 Neutral MLH1 P40692 A442I 442 A I 0.404 Neutral MLH1 P40692 A442K 442 A K 0.256 Neutral MLH1 P40692 A442L 442 A L 0.326 Neutral MLH1 P40692 A442M 442 A M 0.242 Neutral MLH1 P40692 A442N 442 A N 0.298 Neutral MLH1 P40692 A442P 442 A P 0.04 Neutral MLH1 P40692 A442Q 442 A Q 0.25 Neutral MLH1 P40692 A442R 442 A R 0.378 Neutral MLH1 P40692 A442S 442 A S 0.006 Neutral MLH1 P40692 A442T 442 A T 0.016 Neutral MLH1 P40692 A442V 442 A V 0.044 Neutral MLH1 P40692 A442W 442 A W 0.514 Pathogenic MLH1 P40692 A442Y 442 A Y 0.502 Pathogenic MLH1 P40692 K443A 443 K A 0.028 Neutral MLH1 P40692 K443C 443 K C 0.028 Neutral MLH1 P40692 K443D 443 K D 0.002 Neutral MLH1 P40692 K443E 443 K E 0.004 Neutral MLH1 P40692 K443F 443 K F 0.064 Neutral MLH1 P40692 K443G 443 K G 0.062 Neutral MLH1 P40692 K443H 443 K H 0.048 Neutral MLH1 P40692 K443I 443 K I 0.058 Neutral MLH1 P40692 K443L 443 K L 0.036 Neutral MLH1 P40692 K443M 443 K M 0.038 Neutral MLH1 P40692 K443N 443 K N 0.006 Neutral MLH1 P40692 K443P 443 K P 0.01 Neutral MLH1 P40692 K443Q 443 K Q 0.048 Neutral MLH1 P40692 K443R 443 K R 0.004 Neutral MLH1 P40692 K443S 443 K S 0.012 Neutral MLH1 P40692 K443T 443 K T 0.014 Neutral MLH1 P40692 K443V 443 K V 0.024 Neutral MLH1 P40692 K443W 443 K W 0.396 Neutral MLH1 P40692 K443Y 443 K Y 0.324 Neutral MLH1 P40692 N444A 444 N A 0.004 Neutral MLH1 P40692 N444C 444 N C 0.158 Neutral MLH1 P40692 N444D 444 N D 0.008 Neutral MLH1 P40692 N444E 444 N E 0.016 Neutral MLH1 P40692 N444F 444 N F 0.34 Neutral MLH1 P40692 N444G 444 N G 0.022 Neutral MLH1 P40692 N444H 444 N H 0.024 Neutral MLH1 P40692 N444I 444 N I 0.336 Neutral MLH1 P40692 N444K 444 N K 0.038 Neutral MLH1 P40692 N444L 444 N L 0.314 Neutral MLH1 P40692 N444M 444 N M 0.038 Neutral MLH1 P40692 N444P 444 N P 0.248 Neutral MLH1 P40692 N444Q 444 N Q 0.114 Neutral MLH1 P40692 N444R 444 N R 0.164 Neutral MLH1 P40692 N444S 444 N S 0 Neutral MLH1 P40692 N444T 444 N T 0.08 Neutral MLH1 P40692 N444V 444 N V 0.032 Neutral MLH1 P40692 N444W 444 N W 0.446 Neutral MLH1 P40692 N444Y 444 N Y 0.402 Neutral MLH1 P40692 Q445A 445 Q A 0.036 Neutral MLH1 P40692 Q445C 445 Q C 0.082 Neutral MLH1 P40692 Q445D 445 Q D 0.002 Neutral MLH1 P40692 Q445E 445 Q E 0.008 Neutral MLH1 P40692 Q445F 445 Q F 0.26 Neutral MLH1 P40692 Q445G 445 Q G 0.136 Neutral MLH1 P40692 Q445H 445 Q H 0.214 Neutral MLH1 P40692 Q445I 445 Q I 0.278 Neutral MLH1 P40692 Q445K 445 Q K 0.024 Neutral MLH1 P40692 Q445L 445 Q L 0.214 Neutral MLH1 P40692 Q445M 445 Q M 0.21 Neutral MLH1 P40692 Q445N 445 Q N 0.064 Neutral MLH1 P40692 Q445P 445 Q P 0.22 Neutral MLH1 P40692 Q445R 445 Q R 0.024 Neutral MLH1 P40692 Q445S 445 Q S 0.036 Neutral MLH1 P40692 Q445T 445 Q T 0.002 Neutral MLH1 P40692 Q445V 445 Q V 0.268 Neutral MLH1 P40692 Q445W 445 Q W 0.42 Neutral MLH1 P40692 Q445Y 445 Q Y 0.362 Neutral MLH1 P40692 S446A 446 S A 0.01 Neutral MLH1 P40692 S446C 446 S C 0.022 Neutral MLH1 P40692 S446D 446 S D 0.002 Neutral MLH1 P40692 S446E 446 S E 0.124 Neutral MLH1 P40692 S446F 446 S F 0.276 Neutral MLH1 P40692 S446G 446 S G 0 Neutral MLH1 P40692 S446H 446 S H 0.238 Neutral MLH1 P40692 S446I 446 S I 0.196 Neutral MLH1 P40692 S446K 446 S K 0.14 Neutral MLH1 P40692 S446L 446 S L 0.068 Neutral MLH1 P40692 S446M 446 S M 0.27 Neutral MLH1 P40692 S446N 446 S N 0.002 Neutral MLH1 P40692 S446P 446 S P 0.062 Neutral MLH1 P40692 S446Q 446 S Q 0.158 Neutral MLH1 P40692 S446R 446 S R 0.156 Neutral MLH1 P40692 S446T 446 S T 0.02 Neutral MLH1 P40692 S446V 446 S V 0.038 Neutral MLH1 P40692 S446W 446 S W 0.49 Neutral MLH1 P40692 S446Y 446 S Y 0.448 Neutral MLH1 P40692 L447A 447 L A 0.064 Neutral MLH1 P40692 L447C 447 L C 0.056 Neutral MLH1 P40692 L447D 447 L D 0.158 Neutral MLH1 P40692 L447E 447 L E 0.028 Neutral MLH1 P40692 L447F 447 L F 0.204 Neutral MLH1 P40692 L447G 447 L G 0.054 Neutral MLH1 P40692 L447H 447 L H 0.084 Neutral MLH1 P40692 L447I 447 L I 0.072 Neutral MLH1 P40692 L447K 447 L K 0.022 Neutral MLH1 P40692 L447M 447 L M 0.08 Neutral MLH1 P40692 L447N 447 L N 0.138 Neutral MLH1 P40692 L447P 447 L P 0.092 Neutral MLH1 P40692 L447Q 447 L Q 0.064 Neutral MLH1 P40692 L447R 447 L R 0.28 Neutral MLH1 P40692 L447S 447 L S 0.01 Neutral MLH1 P40692 L447T 447 L T 0.012 Neutral MLH1 P40692 L447V 447 L V 0 Neutral MLH1 P40692 L447W 447 L W 0.27 Neutral MLH1 P40692 L447Y 447 L Y 0.284 Neutral MLH1 P40692 E448A 448 E A 0.118 Neutral MLH1 P40692 E448C 448 E C 0.068 Neutral MLH1 P40692 E448D 448 E D 0.038 Neutral MLH1 P40692 E448F 448 E F 0.312 Neutral MLH1 P40692 E448G 448 E G 0.024 Neutral MLH1 P40692 E448H 448 E H 0.104 Neutral MLH1 P40692 E448I 448 E I 0.284 Neutral MLH1 P40692 E448K 448 E K 0.068 Neutral MLH1 P40692 E448L 448 E L 0.286 Neutral MLH1 P40692 E448M 448 E M 0.076 Neutral MLH1 P40692 E448N 448 E N 0.04 Neutral MLH1 P40692 E448P 448 E P 0.064 Neutral MLH1 P40692 E448Q 448 E Q 0 Neutral MLH1 P40692 E448R 448 E R 0.01 Neutral MLH1 P40692 E448S 448 E S 0.014 Neutral MLH1 P40692 E448T 448 E T 0.006 Neutral MLH1 P40692 E448V 448 E V 0.25 Neutral MLH1 P40692 E448W 448 E W 0.43 Neutral MLH1 P40692 E448Y 448 E Y 0.338 Neutral MLH1 P40692 G449A 449 G A 0.008 Neutral MLH1 P40692 G449C 449 G C 0.14 Neutral MLH1 P40692 G449D 449 G D 0.134 Neutral MLH1 P40692 G449E 449 G E 0.192 Neutral MLH1 P40692 G449F 449 G F 0.498 Neutral MLH1 P40692 G449H 449 G H 0.37 Neutral MLH1 P40692 G449I 449 G I 0.412 Neutral MLH1 P40692 G449K 449 G K 0.312 Neutral MLH1 P40692 G449L 449 G L 0.412 Neutral MLH1 P40692 G449M 449 G M 0.422 Neutral MLH1 P40692 G449N 449 G N 0.172 Neutral MLH1 P40692 G449P 449 G P 0.392 Neutral MLH1 P40692 G449Q 449 G Q 0.194 Neutral MLH1 P40692 G449R 449 G R 0.304 Neutral MLH1 P40692 G449S 449 G S 0.018 Neutral MLH1 P40692 G449T 449 G T 0.274 Neutral MLH1 P40692 G449V 449 G V 0.394 Neutral MLH1 P40692 G449W 449 G W 0.498 Neutral MLH1 P40692 G449Y 449 G Y 0.482 Neutral MLH1 P40692 T45A 45 T A 0.26 Neutral MLH1 P40692 T45C 45 T C 0.82 Pathogenic MLH1 P40692 T45D 45 T D 0.832 Pathogenic MLH1 P40692 T45E 45 T E 0.9 Pathogenic MLH1 P40692 T45F 45 T F 0.912 Pathogenic MLH1 P40692 T45G 45 T G 0.586 Pathogenic MLH1 P40692 T45H 45 T H 0.838 Pathogenic MLH1 P40692 T45I 45 T I 0.88 Pathogenic MLH1 P40692 T45K 45 T K 0.378 Neutral MLH1 P40692 T45L 45 T L 0.866 Pathogenic MLH1 P40692 T45M 45 T M 0.95 Pathogenic MLH1 P40692 T45N 45 T N 0.13 Neutral MLH1 P40692 T45P 45 T P 0.908 Pathogenic MLH1 P40692 T45Q 45 T Q 0.762 Pathogenic MLH1 P40692 T45R 45 T R 0.696 Pathogenic MLH1 P40692 T45S 45 T S 0.062 Neutral MLH1 P40692 T45V 45 T V 0.896 Pathogenic MLH1 P40692 T45W 45 T W 0.994 Pathogenic MLH1 P40692 T45Y 45 T Y 0.994 Pathogenic MLH1 P40692 D450A 450 D A 0.072 Neutral MLH1 P40692 D450C 450 D C 0.148 Neutral MLH1 P40692 D450E 450 D E 0.014 Neutral MLH1 P40692 D450F 450 D F 0.406 Neutral MLH1 P40692 D450G 450 D G 0.17 Neutral MLH1 P40692 D450H 450 D H 0.09 Neutral MLH1 P40692 D450I 450 D I 0.11 Neutral MLH1 P40692 D450K 450 D K 0.21 Neutral MLH1 P40692 D450L 450 D L 0.108 Neutral MLH1 P40692 D450M 450 D M 0.19 Neutral MLH1 P40692 D450N 450 D N 0.058 Neutral MLH1 P40692 D450P 450 D P 0.288 Neutral MLH1 P40692 D450Q 450 D Q 0.172 Neutral MLH1 P40692 D450R 450 D R 0.152 Neutral MLH1 P40692 D450S 450 D S 0.074 Neutral MLH1 P40692 D450T 450 D T 0.154 Neutral MLH1 P40692 D450V 450 D V 0.242 Neutral MLH1 P40692 D450W 450 D W 0.434 Neutral MLH1 P40692 D450Y 450 D Y 0.404 Neutral MLH1 P40692 T451A 451 T A 0 Neutral MLH1 P40692 T451C 451 T C 0.034 Neutral MLH1 P40692 T451D 451 T D 0.02 Neutral MLH1 P40692 T451E 451 T E 0.024 Neutral MLH1 P40692 T451F 451 T F 0.214 Neutral MLH1 P40692 T451G 451 T G 0.056 Neutral MLH1 P40692 T451H 451 T H 0.084 Neutral MLH1 P40692 T451I 451 T I 0.076 Neutral MLH1 P40692 T451K 451 T K 0.032 Neutral MLH1 P40692 T451L 451 T L 0.008 Neutral MLH1 P40692 T451M 451 T M 0.098 Neutral MLH1 P40692 T451N 451 T N 0.02 Neutral MLH1 P40692 T451P 451 T P 0.056 Neutral MLH1 P40692 T451Q 451 T Q 0.01 Neutral MLH1 P40692 T451R 451 T R 0.174 Neutral MLH1 P40692 T451S 451 T S 0 Neutral MLH1 P40692 T451V 451 T V 0.046 Neutral MLH1 P40692 T451W 451 T W 0.466 Neutral MLH1 P40692 T451Y 451 T Y 0.424 Neutral MLH1 P40692 T452A 452 T A 0.014 Neutral MLH1 P40692 T452C 452 T C 0.064 Neutral MLH1 P40692 T452D 452 T D 0.046 Neutral MLH1 P40692 T452E 452 T E 0.024 Neutral MLH1 P40692 T452F 452 T F 0.204 Neutral MLH1 P40692 T452G 452 T G 0.036 Neutral MLH1 P40692 T452H 452 T H 0.056 Neutral MLH1 P40692 T452I 452 T I 0.066 Neutral MLH1 P40692 T452K 452 T K 0.008 Neutral MLH1 P40692 T452L 452 T L 0.008 Neutral MLH1 P40692 T452M 452 T M 0.098 Neutral MLH1 P40692 T452N 452 T N 0 Neutral MLH1 P40692 T452P 452 T P 0.008 Neutral MLH1 P40692 T452Q 452 T Q 0 Neutral MLH1 P40692 T452R 452 T R 0.156 Neutral MLH1 P40692 T452S 452 T S 0 Neutral MLH1 P40692 T452V 452 T V 0.018 Neutral MLH1 P40692 T452W 452 T W 0.466 Neutral MLH1 P40692 T452Y 452 T Y 0.424 Neutral MLH1 P40692 K453A 453 K A 0.054 Neutral MLH1 P40692 K453C 453 K C 0.028 Neutral MLH1 P40692 K453D 453 K D 0.002 Neutral MLH1 P40692 K453E 453 K E 0.004 Neutral MLH1 P40692 K453F 453 K F 0.212 Neutral MLH1 P40692 K453G 453 K G 0.042 Neutral MLH1 P40692 K453H 453 K H 0.048 Neutral MLH1 P40692 K453I 453 K I 0.222 Neutral MLH1 P40692 K453L 453 K L 0.148 Neutral MLH1 P40692 K453M 453 K M 0.028 Neutral MLH1 P40692 K453N 453 K N 0.014 Neutral MLH1 P40692 K453P 453 K P 0.214 Neutral MLH1 P40692 K453Q 453 K Q 0.006 Neutral MLH1 P40692 K453R 453 K R 0.002 Neutral MLH1 P40692 K453S 453 K S 0.012 Neutral MLH1 P40692 K453T 453 K T 0.012 Neutral MLH1 P40692 K453V 453 K V 0.184 Neutral MLH1 P40692 K453W 453 K W 0.396 Neutral MLH1 P40692 K453Y 453 K Y 0.326 Neutral MLH1 P40692 G454A 454 G A 0.002 Neutral MLH1 P40692 G454C 454 G C 0.14 Neutral MLH1 P40692 G454D 454 G D 0.154 Neutral MLH1 P40692 G454E 454 G E 0.192 Neutral MLH1 P40692 G454F 454 G F 0.498 Neutral MLH1 P40692 G454H 454 G H 0.442 Neutral MLH1 P40692 G454I 454 G I 0.428 Neutral MLH1 P40692 G454K 454 G K 0.284 Neutral MLH1 P40692 G454L 454 G L 0.37 Neutral MLH1 P40692 G454M 454 G M 0.422 Neutral MLH1 P40692 G454N 454 G N 0.168 Neutral MLH1 P40692 G454P 454 G P 0.35 Neutral MLH1 P40692 G454Q 454 G Q 0.18 Neutral MLH1 P40692 G454R 454 G R 0.304 Neutral MLH1 P40692 G454S 454 G S 0.016 Neutral MLH1 P40692 G454T 454 G T 0.266 Neutral MLH1 P40692 G454V 454 G V 0.344 Neutral MLH1 P40692 G454W 454 G W 0.498 Neutral MLH1 P40692 G454Y 454 G Y 0.5 Pathogenic MLH1 P40692 T455A 455 T A 0 Neutral MLH1 P40692 T455C 455 T C 0.064 Neutral MLH1 P40692 T455D 455 T D 0.022 Neutral MLH1 P40692 T455E 455 T E 0.032 Neutral MLH1 P40692 T455F 455 T F 0.204 Neutral MLH1 P40692 T455G 455 T G 0.056 Neutral MLH1 P40692 T455H 455 T H 0.032 Neutral MLH1 P40692 T455I 455 T I 0.096 Neutral MLH1 P40692 T455K 455 T K 0.042 Neutral MLH1 P40692 T455L 455 T L 0.074 Neutral MLH1 P40692 T455M 455 T M 0.044 Neutral MLH1 P40692 T455N 455 T N 0.02 Neutral MLH1 P40692 T455P 455 T P 0.008 Neutral MLH1 P40692 T455Q 455 T Q 0.016 Neutral MLH1 P40692 T455R 455 T R 0.156 Neutral MLH1 P40692 T455S 455 T S 0 Neutral MLH1 P40692 T455V 455 T V 0.016 Neutral MLH1 P40692 T455W 455 T W 0.466 Neutral MLH1 P40692 T455Y 455 T Y 0.424 Neutral MLH1 P40692 S456A 456 S A 0.01 Neutral MLH1 P40692 S456C 456 S C 0.022 Neutral MLH1 P40692 S456D 456 S D 0.002 Neutral MLH1 P40692 S456E 456 S E 0.124 Neutral MLH1 P40692 S456F 456 S F 0.25 Neutral MLH1 P40692 S456G 456 S G 0 Neutral MLH1 P40692 S456H 456 S H 0.17 Neutral MLH1 P40692 S456I 456 S I 0.17 Neutral MLH1 P40692 S456K 456 S K 0.164 Neutral MLH1 P40692 S456L 456 S L 0.026 Neutral MLH1 P40692 S456M 456 S M 0.266 Neutral MLH1 P40692 S456N 456 S N 0.012 Neutral MLH1 P40692 S456P 456 S P 0.062 Neutral MLH1 P40692 S456Q 456 S Q 0.16 Neutral MLH1 P40692 S456R 456 S R 0.17 Neutral MLH1 P40692 S456T 456 S T 0.02 Neutral MLH1 P40692 S456V 456 S V 0.034 Neutral MLH1 P40692 S456W 456 S W 0.49 Neutral MLH1 P40692 S456Y 456 S Y 0.434 Neutral MLH1 P40692 E457A 457 E A 0.118 Neutral MLH1 P40692 E457C 457 E C 0.09 Neutral MLH1 P40692 E457D 457 E D 0 Neutral MLH1 P40692 E457F 457 E F 0.164 Neutral MLH1 P40692 E457G 457 E G 0.054 Neutral MLH1 P40692 E457H 457 E H 0.04 Neutral MLH1 P40692 E457I 457 E I 0.122 Neutral MLH1 P40692 E457K 457 E K 0.026 Neutral MLH1 P40692 E457L 457 E L 0.038 Neutral MLH1 P40692 E457M 457 E M 0.164 Neutral MLH1 P40692 E457N 457 E N 0.04 Neutral MLH1 P40692 E457P 457 E P 0.042 Neutral MLH1 P40692 E457Q 457 E Q 0 Neutral MLH1 P40692 E457R 457 E R 0.01 Neutral MLH1 P40692 E457S 457 E S 0.014 Neutral MLH1 P40692 E457T 457 E T 0.006 Neutral MLH1 P40692 E457V 457 E V 0.04 Neutral MLH1 P40692 E457W 457 E W 0.43 Neutral MLH1 P40692 E457Y 457 E Y 0.338 Neutral MLH1 P40692 M458A 458 M A 0.046 Neutral MLH1 P40692 M458C 458 M C 0.032 Neutral MLH1 P40692 M458D 458 M D 0.06 Neutral MLH1 P40692 M458E 458 M E 0.008 Neutral MLH1 P40692 M458F 458 M F 0.078 Neutral MLH1 P40692 M458G 458 M G 0.038 Neutral MLH1 P40692 M458H 458 M H 0.058 Neutral MLH1 P40692 M458I 458 M I 0.09 Neutral MLH1 P40692 M458K 458 M K 0.016 Neutral MLH1 P40692 M458L 458 M L 0.004 Neutral MLH1 P40692 M458N 458 M N 0.072 Neutral MLH1 P40692 M458P 458 M P 0.038 Neutral MLH1 P40692 M458Q 458 M Q 0.002 Neutral MLH1 P40692 M458R 458 M R 0.042 Neutral MLH1 P40692 M458S 458 M S 0.008 Neutral MLH1 P40692 M458T 458 M T 0.008 Neutral MLH1 P40692 M458V 458 M V 0.068 Neutral MLH1 P40692 M458W 458 M W 0.422 Neutral MLH1 P40692 M458Y 458 M Y 0.348 Neutral MLH1 P40692 S459A 459 S A 0.012 Neutral MLH1 P40692 S459C 459 S C 0.022 Neutral MLH1 P40692 S459D 459 S D 0.002 Neutral MLH1 P40692 S459E 459 S E 0.122 Neutral MLH1 P40692 S459F 459 S F 0.276 Neutral MLH1 P40692 S459G 459 S G 0 Neutral MLH1 P40692 S459H 459 S H 0.238 Neutral MLH1 P40692 S459I 459 S I 0.17 Neutral MLH1 P40692 S459K 459 S K 0.146 Neutral MLH1 P40692 S459L 459 S L 0.062 Neutral MLH1 P40692 S459M 459 S M 0.28 Neutral MLH1 P40692 S459N 459 S N 0 Neutral MLH1 P40692 S459P 459 S P 0.062 Neutral MLH1 P40692 S459Q 459 S Q 0.17 Neutral MLH1 P40692 S459R 459 S R 0.152 Neutral MLH1 P40692 S459T 459 S T 0.02 Neutral MLH1 P40692 S459V 459 S V 0.034 Neutral MLH1 P40692 S459W 459 S W 0.472 Neutral MLH1 P40692 S459Y 459 S Y 0.448 Neutral MLH1 P40692 S46A 46 S A 0.08 Neutral MLH1 P40692 S46C 46 S C 0.086 Neutral MLH1 P40692 S46D 46 S D 0.434 Neutral MLH1 P40692 S46E 46 S E 0.542 Pathogenic MLH1 P40692 S46F 46 S F 0.768 Pathogenic MLH1 P40692 S46G 46 S G 0.342 Neutral MLH1 P40692 S46H 46 S H 0.464 Neutral MLH1 P40692 S46I 46 S I 0.564 Pathogenic MLH1 P40692 S46K 46 S K 0.542 Pathogenic MLH1 P40692 S46L 46 S L 0.16 Neutral MLH1 P40692 S46M 46 S M 0.566 Pathogenic MLH1 P40692 S46N 46 S N 0.056 Neutral MLH1 P40692 S46P 46 S P 0.558 Pathogenic MLH1 P40692 S46Q 46 S Q 0.448 Neutral MLH1 P40692 S46R 46 S R 0.75 Pathogenic MLH1 P40692 S46T 46 S T 0.06 Neutral MLH1 P40692 S46V 46 S V 0.796 Pathogenic MLH1 P40692 S46W 46 S W 0.928 Pathogenic MLH1 P40692 S46Y 46 S Y 0.902 Pathogenic MLH1 P40692 E460A 460 E A 0.066 Neutral 1 MLH1 P40692 E460C 460 E C 0.064 Neutral MLH1 P40692 E460D 460 E D 0 Neutral MLH1 P40692 E460F 460 E F 0.312 Neutral MLH1 P40692 E460G 460 E G 0.024 Neutral MLH1 P40692 E460H 460 E H 0.018 Neutral MLH1 P40692 E460I 460 E I 0.128 Neutral MLH1 P40692 E460K 460 E K 0.006 Neutral MLH1 P40692 E460L 460 E L 0.038 Neutral MLH1 P40692 E460M 460 E M 0.164 Neutral MLH1 P40692 E460N 460 E N 0.002 Neutral MLH1 P40692 E460P 460 E P 0.046 Neutral MLH1 P40692 E460Q 460 E Q 0 Neutral MLH1 P40692 E460R 460 E R 0.01 Neutral MLH1 P40692 E460S 460 E S 0.014 Neutral MLH1 P40692 E460T 460 E T 0.006 Neutral MLH1 P40692 E460V 460 E V 0.032 Neutral MLH1 P40692 E460W 460 E W 0.43 Neutral MLH1 P40692 E460Y 460 E Y 0.338 Neutral MLH1 P40692 K461A 461 K A 0.028 Neutral MLH1 P40692 K461C 461 K C 0.036 Neutral MLH1 P40692 K461D 461 K D 0.002 Neutral MLH1 P40692 K461E 461 K E 0.004 Neutral MLH1 P40692 K461F 461 K F 0.114 Neutral MLH1 P40692 K461G 461 K G 0.042 Neutral MLH1 P40692 K461H 461 K H 0.018 Neutral MLH1 P40692 K461I 461 K I 0.04 Neutral MLH1 P40692 K461L 461 K L 0.036 Neutral MLH1 P40692 K461M 461 K M 0.038 Neutral MLH1 P40692 K461N 461 K N 0.014 Neutral MLH1 P40692 K461P 461 K P 0.016 Neutral MLH1 P40692 K461Q 461 K Q 0.006 Neutral MLH1 P40692 K461R 461 K R 0.002 Neutral MLH1 P40692 K461S 461 K S 0.012 Neutral MLH1 P40692 K461T 461 K T 0.012 Neutral MLH1 P40692 K461V 461 K V 0.026 Neutral MLH1 P40692 K461W 461 K W 0.396 Neutral MLH1 P40692 K461Y 461 K Y 0.326 Neutral MLH1 P40692 R462A 462 R A 0.036 Neutral MLH1 P40692 R462C 462 R C 0.148 Neutral MLH1 P40692 R462D 462 R D 0.02 Neutral MLH1 P40692 R462E 462 R E 0.022 Neutral MLH1 P40692 R462F 462 R F 0.27 Neutral MLH1 P40692 R462G 462 R G 0.002 Neutral MLH1 P40692 R462H 462 R H 0.12 Neutral MLH1 P40692 R462I 462 R I 0.194 Neutral MLH1 P40692 R462K 462 R K 0.004 Neutral MLH1 P40692 R462L 462 R L 0.012 Neutral MLH1 P40692 R462M 462 R M 0.066 Neutral MLH1 P40692 R462N 462 R N 0.008 Neutral MLH1 P40692 R462P 462 R P 0.028 Neutral MLH1 P40692 R462Q 462 R Q 0.028 Neutral MLH1 P40692 R462S 462 R S 0.016 Neutral MLH1 P40692 R462T 462 R T 0.016 Neutral MLH1 P40692 R462V 462 R V 0.032 Neutral MLH1 P40692 R462W 462 R W 0.282 Neutral MLH1 P40692 R462Y 462 R Y 0.284 Neutral MLH1 P40692 G463A 463 G A 0.002 Neutral MLH1 P40692 G463C 463 G C 0.17 Neutral MLH1 P40692 G463D 463 G D 0.134 Neutral MLH1 P40692 G463E 463 G E 0.192 Neutral MLH1 P40692 G463F 463 G F 0.498 Neutral MLH1 P40692 G463H 463 G H 0.324 Neutral MLH1 P40692 G463I 463 G I 0.416 Neutral MLH1 P40692 G463K 463 G K 0.284 Neutral MLH1 P40692 G463L 463 G L 0.37 Neutral MLH1 P40692 G463M 463 G M 0.314 Neutral MLH1 P40692 G463N 463 G N 0.172 Neutral MLH1 P40692 G463P 463 G P 0.35 Neutral MLH1 P40692 G463Q 463 G Q 0.208 Neutral MLH1 P40692 G463R 463 G R 0.324 Neutral MLH1 P40692 G463S 463 G S 0.014 Neutral MLH1 P40692 G463T 463 G T 0.266 Neutral MLH1 P40692 G463V 463 G V 0.394 Neutral MLH1 P40692 G463W 463 G W 0.498 Neutral MLH1 P40692 G463Y 463 G Y 0.5 Pathogenic MLH1 P40692 P464A 464 P A 0.052 Neutral MLH1 P40692 P464C 464 P C 0.148 Neutral MLH1 P40692 P464D 464 P D 0.078 Neutral MLH1 P40692 P464E 464 P E 0.166 Neutral MLH1 P40692 P464F 464 P F 0.226 Neutral MLH1 P40692 P464G 464 P G 0.024 Neutral MLH1 P40692 P464H 464 P H 0.266 Neutral MLH1 P40692 P464I 464 P I 0.042 Neutral MLH1 P40692 P464K 464 P K 0.06 Neutral MLH1 P40692 P464L 464 P L 0.044 Neutral MLH1 P40692 P464M 464 P M 0.146 Neutral MLH1 P40692 P464N 464 P N 0.068 Neutral MLH1 P40692 P464Q 464 P Q 0.15 Neutral MLH1 P40692 P464R 464 P R 0.222 Neutral MLH1 P40692 P464S 464 P S 0.002 Neutral MLH1 P40692 P464T 464 P T 0.122 Neutral MLH1 P40692 P464V 464 P V 0.07 Neutral MLH1 P40692 P464W 464 P W 0.328 Neutral MLH1 P40692 P464Y 464 P Y 0.32 Neutral MLH1 P40692 T465A 465 T A 0 Neutral MLH1 P40692 T465C 465 T C 0.064 Neutral MLH1 P40692 T465D 465 T D 0.038 Neutral MLH1 P40692 T465E 465 T E 0.032 Neutral MLH1 P40692 T465F 465 T F 0.204 Neutral MLH1 P40692 T465G 465 T G 0.056 Neutral MLH1 P40692 T465H 465 T H 0.084 Neutral MLH1 P40692 T465I 465 T I 0.066 Neutral MLH1 P40692 T465K 465 T K 0.032 Neutral MLH1 P40692 T465L 465 T L 0.07 Neutral MLH1 P40692 T465M 465 T M 0.098 Neutral MLH1 P40692 T465N 465 T N 0.012 Neutral MLH1 P40692 T465P 465 T P 0.008 Neutral MLH1 P40692 T465Q 465 T Q 0.052 Neutral MLH1 P40692 T465R 465 T R 0.174 Neutral MLH1 P40692 T465S 465 T S 0 Neutral MLH1 P40692 T465V 465 T V 0.212 Neutral MLH1 P40692 T465W 465 T W 0.466 Neutral MLH1 P40692 T465Y 465 T Y 0.424 Neutral MLH1 P40692 S466A 466 S A 0.068 Neutral MLH1 P40692 S466C 466 S C 0.008 Neutral MLH1 P40692 S466D 466 S D 0.044 Neutral MLH1 P40692 S466E 466 S E 0.122 Neutral MLH1 P40692 S466F 466 S F 0.264 Neutral MLH1 P40692 S466G 466 S G 0.064 Neutral MLH1 P40692 S466H 466 S H 0.238 Neutral MLH1 P40692 S466I 466 S I 0.196 Neutral MLH1 P40692 S466K 466 S K 0.164 Neutral MLH1 P40692 S466L 466 S L 0.032 Neutral MLH1 P40692 S466M 466 S M 0.332 Neutral MLH1 P40692 S466N 466 S N 0.004 Neutral MLH1 P40692 S466P 466 S P 0.056 Neutral MLH1 P40692 S466Q 466 S Q 0.158 Neutral MLH1 P40692 S466R 466 S R 0.152 Neutral MLH1 P40692 S466T 466 S T 0.11 Neutral MLH1 P40692 S466V 466 S V 0.032 Neutral MLH1 P40692 S466W 466 S W 0.49 Neutral MLH1 P40692 S466Y 466 S Y 0.448 Neutral MLH1 P40692 S467A 467 S A 0.052 Neutral MLH1 P40692 S467C 467 S C 0.032 Neutral MLH1 P40692 S467D 467 S D 0.002 Neutral MLH1 P40692 S467E 467 S E 0.138 Neutral MLH1 P40692 S467F 467 S F 0.264 Neutral MLH1 P40692 S467G 467 S G 0 Neutral MLH1 P40692 S467H 467 S H 0.238 Neutral MLH1 P40692 S467I 467 S I 0.17 Neutral MLH1 P40692 S467K 467 S K 0.14 Neutral MLH1 P40692 S467L 467 S L 0.068 Neutral MLH1 P40692 S467M 467 S M 0.332 Neutral MLH1 P40692 S467N 467 S N 0 Neutral MLH1 P40692 S467P 467 S P 0.066 Neutral MLH1 P40692 S467Q 467 S Q 0.158 Neutral MLH1 P40692 S467R 467 S R 0.152 Neutral MLH1 P40692 S467T 467 S T 0.104 Neutral MLH1 P40692 S467V 467 S V 0.288 Neutral MLH1 P40692 S467W 467 S W 0.49 Neutral MLH1 P40692 S467Y 467 S Y 0.434 Neutral MLH1 P40692 N468A 468 N A 0.004 Neutral MLH1 P40692 N468C 468 N C 0.148 Neutral MLH1 P40692 N468D 468 N D 0.118 Neutral MLH1 P40692 N468E 468 N E 0.04 Neutral MLH1 P40692 N468F 468 N F 0.34 Neutral MLH1 P40692 N468G 468 N G 0.044 Neutral MLH1 P40692 N468H 468 N H 0.262 Neutral MLH1 P40692 N468I 468 N I 0.336 Neutral MLH1 P40692 N468K 468 N K 0.272 Neutral MLH1 P40692 N468L 468 N L 0.074 Neutral MLH1 P40692 N468M 468 N M 0.22 Neutral MLH1 P40692 N468P 468 N P 0.126 Neutral MLH1 P40692 N468Q 468 N Q 0.096 Neutral MLH1 P40692 N468R 468 N R 0.148 Neutral MLH1 P40692 N468S 468 N S 0.02 Neutral MLH1 P40692 N468T 468 N T 0.116 Neutral MLH1 P40692 N468V 468 N V 0.12 Neutral MLH1 P40692 N468W 468 N W 0.446 Neutral MLH1 P40692 N468Y 468 N Y 0.45 Neutral MLH1 P40692 P469A 469 P A 0.032 Neutral MLH1 P40692 P469C 469 P C 0.152 Neutral MLH1 P40692 P469D 469 P D 0.008 Neutral MLH1 P40692 P469E 469 P E 0.184 Neutral MLH1 P40692 P469F 469 P F 0.25 Neutral MLH1 P40692 P469G 469 P G 0.024 Neutral MLH1 P40692 P469H 469 P H 0.246 Neutral MLH1 P40692 P469I 469 P I 0.112 Neutral MLH1 P40692 P469K 469 P K 0.164 Neutral MLH1 P40692 P469L 469 P L 0.116 Neutral MLH1 P40692 P469M 469 P M 0.198 Neutral MLH1 P40692 P469N 469 P N 0.004 Neutral MLH1 P40692 P469Q 469 P Q 0.226 Neutral MLH1 P40692 P469R 469 P R 0.22 Neutral MLH1 P40692 P469S 469 P S 0.002 Neutral MLH1 P40692 P469T 469 P T 0.014 Neutral MLH1 P40692 P469V 469 P V 0.132 Neutral MLH1 P40692 P469W 469 P W 0.408 Neutral MLH1 P40692 P469Y 469 P Y 0.338 Neutral MLH1 P40692 I47A 47 I A 0.476 Neutral MLH1 P40692 I47C 47 I C 0.616 Pathogenic MLH1 P40692 I47D 47 I D 0.762 Pathogenic MLH1 P40692 I47E 47 I E 0.766 Pathogenic MLH1 P40692 I47F 47 I F 0.958 Pathogenic MLH1 P40692 I47G 47 I G 0.81 Pathogenic MLH1 P40692 I47H 47 I H 0.844 Pathogenic MLH1 P40692 I47K 47 I K 0.856 Pathogenic MLH1 P40692 I47L 47 I L 0.086 Neutral MLH1 P40692 I47M 47 I M 0.686 Pathogenic MLH1 P40692 I47N 47 I N 0.79 Pathogenic MLH1 P40692 I47P 47 I P 0.938 Pathogenic MLH1 P40692 I47Q 47 I Q 0.8 Pathogenic MLH1 P40692 I47R 47 I R 0.884 Pathogenic MLH1 P40692 I47S 47 I S 0.626 Pathogenic MLH1 P40692 I47T 47 I T 0.368 Neutral MLH1 P40692 I47V 47 I V 0.12 Neutral MLH1 P40692 I47W 47 I W 0.982 Pathogenic MLH1 P40692 I47Y 47 I Y 0.976 Pathogenic MLH1 P40692 R470A 470 R A 0.08 Neutral MLH1 P40692 R470C 470 R C 0.222 Neutral MLH1 P40692 R470D 470 R D 0.246 Neutral MLH1 P40692 R470E 470 R E 0.23 Neutral MLH1 P40692 R470F 470 R F 0.426 Neutral MLH1 P40692 R470G 470 R G 0.13 Neutral MLH1 P40692 R470H 470 R H 0.09 Neutral MLH1 P40692 R470I 470 R I 0.164 Neutral MLH1 P40692 R470K 470 R K 0.012 Neutral MLH1 P40692 R470L 470 R L 0.122 Neutral MLH1 P40692 R470M 470 R M 0.25 Neutral MLH1 P40692 R470N 470 R N 0.262 Neutral MLH1 P40692 R470P 470 R P 0.408 Neutral MLH1 P40692 R470Q 470 R Q 0.314 Neutral MLH1 P40692 R470S 470 R S 0.024 Neutral MLH1 P40692 R470T 470 R T 0.09 Neutral MLH1 P40692 R470V 470 R V 0.296 Neutral MLH1 P40692 R470W 470 R W 0.614 Pathogenic MLH1 P40692 R470Y 470 R Y 0.44 Neutral MLH1 P40692 K471A 471 K A 0.096 Neutral MLH1 P40692 K471C 471 K C 0.038 Neutral MLH1 P40692 K471D 471 K D 0.002 Neutral MLH1 P40692 K471E 471 K E 0.03 Neutral MLH1 P40692 K471F 471 K F 0.258 Neutral MLH1 P40692 K471G 471 K G 0.142 Neutral MLH1 P40692 K471H 471 K H 0.058 Neutral MLH1 P40692 K471I 471 K I 0.07 Neutral MLH1 P40692 K471L 471 K L 0.194 Neutral MLH1 P40692 K471M 471 K M 0.166 Neutral MLH1 P40692 K471N 471 K N 0.006 Neutral MLH1 P40692 K471P 471 K P 0.26 Neutral MLH1 P40692 K471Q 471 K Q 0.056 Neutral MLH1 P40692 K471R 471 K R 0.038 Neutral MLH1 P40692 K471S 471 K S 0.014 Neutral MLH1 P40692 K471T 471 K T 0.012 Neutral MLH1 P40692 K471V 471 K V 0.028 Neutral MLH1 P40692 K471W 471 K W 0.512 Pathogenic MLH1 P40692 K471Y 471 K Y 0.432 Neutral MLH1 P40692 R472A 472 R A 0.078 Neutral MLH1 P40692 R472C 472 R C 0.24 Neutral MLH1 P40692 R472D 472 R D 0.026 Neutral MLH1 P40692 R472E 472 R E 0.032 Neutral MLH1 P40692 R472F 472 R F 0.432 Neutral MLH1 P40692 R472G 472 R G 0.006 Neutral MLH1 P40692 R472H 472 R H 0.184 Neutral MLH1 P40692 R472I 472 R I 0.468 Neutral MLH1 P40692 R472K 472 R K 0.01 Neutral MLH1 P40692 R472L 472 R L 0.378 Neutral MLH1 P40692 R472M 472 R M 0.252 Neutral MLH1 P40692 R472N 472 R N 0.264 Neutral MLH1 P40692 R472P 472 R P 0.164 Neutral MLH1 P40692 R472Q 472 R Q 0.228 Neutral MLH1 P40692 R472S 472 R S 0.218 Neutral MLH1 P40692 R472T 472 R T 0.21 Neutral MLH1 P40692 R472V 472 R V 0.378 Neutral MLH1 P40692 R472W 472 R W 0.62 Pathogenic MLH1 P40692 R472Y 472 R Y 0.446 Neutral MLH1 P40692 H473A 473 H A 0.042 Neutral MLH1 P40692 H473C 473 H C 0.028 Neutral MLH1 P40692 H473D 473 H D 0 Neutral MLH1 P40692 H473E 473 H E 0 Neutral MLH1 P40692 H473F 473 H F 0.204 Neutral MLH1 P40692 H473G 473 H G 0.11 Neutral MLH1 P40692 H473I 473 H I 0.274 Neutral MLH1 P40692 H473K 473 H K 0.086 Neutral MLH1 P40692 H473L 473 H L 0.232 Neutral MLH1 P40692 H473M 473 H M 0.136 Neutral MLH1 P40692 H473N 473 H N 0.058 Neutral MLH1 P40692 H473P 473 H P 0.026 Neutral MLH1 P40692 H473Q 473 H Q 0.006 Neutral MLH1 P40692 H473R 473 H R 0.012 Neutral MLH1 P40692 H473S 473 H S 0.012 Neutral MLH1 P40692 H473T 473 H T 0.006 Neutral MLH1 P40692 H473V 473 H V 0.132 Neutral MLH1 P40692 H473W 473 H W 0.398 Neutral MLH1 P40692 H473Y 473 H Y 0.306 Neutral MLH1 P40692 R474A 474 R A 0.038 Neutral MLH1 P40692 R474C 474 R C 0.154 Neutral MLH1 P40692 R474D 474 R D 0.024 Neutral MLH1 P40692 R474E 474 R E 0.032 Neutral MLH1 P40692 R474F 474 R F 0.294 Neutral MLH1 P40692 R474G 474 R G 0.002 Neutral MLH1 P40692 R474H 474 R H 0.122 Neutral MLH1 P40692 R474I 474 R I 0.326 Neutral MLH1 P40692 R474K 474 R K 0.004 Neutral MLH1 P40692 R474L 474 R L 0.07 Neutral MLH1 P40692 R474M 474 R M 0.174 Neutral MLH1 P40692 R474N 474 R N 0.01 Neutral MLH1 P40692 R474P 474 R P 0.254 Neutral MLH1 P40692 R474Q 474 R Q 0.116 Neutral MLH1 P40692 R474S 474 R S 0.016 Neutral MLH1 P40692 R474T 474 R T 0.018 Neutral MLH1 P40692 R474V 474 R V 0.062 Neutral MLH1 P40692 R474W 474 R W 0.306 Neutral MLH1 P40692 R474Y 474 R Y 0.308 Neutral MLH1 P40692 E475A 475 E A 0.066 Neutral MLH1 P40692 E475C 475 E C 0.068 Neutral MLH1 P40692 E475D 475 E D 0.004 Neutral MLH1 P40692 E475F 475 E F 0.286 Neutral MLH1 P40692 E475G 475 E G 0.002 Neutral MLH1 P40692 E475H 475 E H 0.164 Neutral MLH1 P40692 E475I 475 E I 0.302 Neutral MLH1 P40692 E475K 475 E K 0.002 Neutral MLH1 P40692 E475L 475 E L 0.304 Neutral MLH1 P40692 E475M 475 E M 0.176 Neutral MLH1 P40692 E475N 475 E N 0.04 Neutral MLH1 P40692 E475P 475 E P 0.046 Neutral MLH1 P40692 E475Q 475 E Q 0.018 Neutral MLH1 P40692 E475R 475 E R 0.038 Neutral MLH1 P40692 E475S 475 E S 0.014 Neutral MLH1 P40692 E475T 475 E T 0.014 Neutral MLH1 P40692 E475V 475 E V 0.044 Neutral MLH1 P40692 E475W 475 E W 0.476 Neutral MLH1 P40692 E475Y 475 E Y 0.442 Neutral MLH1 P40692 D476A 476 D A 0.1 Neutral MLH1 P40692 D476C 476 D C 0.156 Neutral MLH1 P40692 D476E 476 D E 0.018 Neutral MLH1 P40692 D476F 476 D F 0.388 Neutral MLH1 P40692 D476G 476 D G 0.018 Neutral MLH1 P40692 D476H 476 D H 0.164 Neutral MLH1 P40692 D476I 476 D I 0.112 Neutral MLH1 P40692 D476K 476 D K 0.02 Neutral MLH1 P40692 D476L 476 D L 0.112 Neutral MLH1 P40692 D476M 476 D M 0.198 Neutral MLH1 P40692 D476N 476 D N 0 Neutral MLH1 P40692 D476P 476 D P 0.042 Neutral MLH1 P40692 D476Q 476 D Q 0.174 Neutral MLH1 P40692 D476R 476 D R 0.17 Neutral MLH1 P40692 D476S 476 D S 0.002 Neutral MLH1 P40692 D476T 476 D T 0.016 Neutral MLH1 P40692 D476V 476 D V 0.106 Neutral MLH1 P40692 D476W 476 D W 0.452 Neutral MLH1 P40692 D476Y 476 D Y 0.458 Neutral MLH1 P40692 S477A 477 S A 0.01 Neutral MLH1 P40692 S477C 477 S C 0.022 Neutral MLH1 P40692 S477D 477 S D 0.002 Neutral MLH1 P40692 S477E 477 S E 0.138 Neutral MLH1 P40692 S477F 477 S F 0.27 Neutral MLH1 P40692 S477G 477 S G 0 Neutral MLH1 P40692 S477H 477 S H 0.178 Neutral MLH1 P40692 S477I 477 S I 0.126 Neutral MLH1 P40692 S477K 477 S K 0.152 Neutral MLH1 P40692 S477L 477 S L 0.026 Neutral MLH1 P40692 S477M 477 S M 0.26 Neutral MLH1 P40692 S477N 477 S N 0.014 Neutral MLH1 P40692 S477P 477 S P 0.062 Neutral MLH1 P40692 S477Q 477 S Q 0.17 Neutral MLH1 P40692 S477R 477 S R 0.176 Neutral MLH1 P40692 S477T 477 S T 0.02 Neutral MLH1 P40692 S477V 477 S V 0.036 Neutral MLH1 P40692 S477W 477 S W 0.502 Pathogenic MLH1 P40692 S477Y 477 S Y 0.448 Neutral MLH1 P40692 D478A 478 D A 0.014 Neutral MLH1 P40692 D478C 478 D C 0.168 Neutral MLH1 P40692 D478E 478 D E 0.014 Neutral MLH1 P40692 D478F 478 D F 0.526 Pathogenic MLH1 P40692 D478G 478 D G 0.018 Neutral MLH1 P40692 D478H 478 D H 0.176 Neutral MLH1 P40692 D478I 478 D I 0.366 Neutral MLH1 P40692 D478K 478 D K 0.02 Neutral MLH1 P40692 D478L 478 D L 0.314 Neutral MLH1 P40692 D478M 478 D M 0.074 Neutral MLH1 P40692 D478N 478 D N 0 Neutral MLH1 P40692 D478P 478 D P 0.078 Neutral MLH1 P40692 D478Q 478 D Q 0.014 Neutral MLH1 P40692 D478R 478 D R 0.192 Neutral MLH1 P40692 D478S 478 D S 0.002 Neutral MLH1 P40692 D478T 478 D T 0.016 Neutral MLH1 P40692 D478V 478 D V 0.078 Neutral MLH1 P40692 D478W 478 D W 0.55 Pathogenic MLH1 P40692 D478Y 478 D Y 0.52 Pathogenic MLH1 P40692 V479A 479 V A 0 Neutral MLH1 P40692 V479C 479 V C 0.058 Neutral MLH1 P40692 V479D 479 V D 0.028 Neutral MLH1 P40692 V479E 479 V E 0.046 Neutral MLH1 P40692 V479F 479 V F 0.152 Neutral MLH1 P40692 V479G 479 V G 0.038 Neutral MLH1 P40692 V479H 479 V H 0.074 Neutral MLH1 P40692 V479I 479 V I 0.002 Neutral MLH1 P40692 V479K 479 V K 0.064 Neutral MLH1 P40692 V479L 479 V L 0 Neutral MLH1 P40692 V479M 479 V M 0.014 Neutral MLH1 P40692 V479N 479 V N 0.04 Neutral MLH1 P40692 V479P 479 V P 0.038 Neutral MLH1 P40692 V479Q 479 V Q 0.052 Neutral MLH1 P40692 V479R 479 V R 0.23 Neutral MLH1 P40692 V479S 479 V S 0.01 Neutral MLH1 P40692 V479T 479 V T 0.008 Neutral MLH1 P40692 V479W 479 V W 0.348 Neutral MLH1 P40692 V479Y 479 V Y 0.186 Neutral MLH1 P40692 Q48A 48 Q A 0.442 Neutral MLH1 P40692 Q48C 48 Q C 0.414 Neutral MLH1 P40692 Q48D 48 Q D 0.026 Neutral MLH1 P40692 Q48E 48 Q E 0.03 Neutral MLH1 P40692 Q48F 48 Q F 0.778 Pathogenic MLH1 P40692 Q48G 48 Q G 0.444 Neutral MLH1 P40692 Q48H 48 Q H 0.744 Pathogenic MLH1 P40692 Q48I 48 Q I 0.416 Neutral MLH1 P40692 Q48K 48 Q K 0.056 Neutral MLH1 P40692 Q48L 48 Q L 0.71 Pathogenic MLH1 P40692 Q48M 48 Q M 0.678 Pathogenic MLH1 P40692 Q48N 48 Q N 0.086 Neutral MLH1 P40692 Q48P 48 Q P 0.888 Pathogenic 4 MLH1 P40692 Q48R 48 Q R 0.048 Neutral MLH1 P40692 Q48S 48 Q S 0.094 Neutral MLH1 P40692 Q48T 48 Q T 0.028 Neutral MLH1 P40692 Q48V 48 Q V 0.79 Pathogenic MLH1 P40692 Q48W 48 Q W 0.894 Pathogenic MLH1 P40692 Q48Y 48 Q Y 0.85 Pathogenic MLH1 P40692 E480A 480 E A 0.068 Neutral MLH1 P40692 E480C 480 E C 0.068 Neutral MLH1 P40692 E480D 480 E D 0 Neutral MLH1 P40692 E480F 480 E F 0.336 Neutral MLH1 P40692 E480G 480 E G 0.024 Neutral MLH1 P40692 E480H 480 E H 0.04 Neutral MLH1 P40692 E480I 480 E I 0.134 Neutral MLH1 P40692 E480K 480 E K 0.002 Neutral MLH1 P40692 E480L 480 E L 0.046 Neutral MLH1 P40692 E480M 480 E M 0.04 Neutral MLH1 P40692 E480N 480 E N 0.04 Neutral MLH1 P40692 E480P 480 E P 0.05 Neutral MLH1 P40692 E480Q 480 E Q 0 Neutral MLH1 P40692 E480R 480 E R 0.012 Neutral MLH1 P40692 E480S 480 E S 0.018 Neutral MLH1 P40692 E480T 480 E T 0.008 Neutral MLH1 P40692 E480V 480 E V 0.038 Neutral MLH1 P40692 E480W 480 E W 0.478 Neutral MLH1 P40692 E480Y 480 E Y 0.226 Neutral MLH1 P40692 M481A 481 M A 0.046 Neutral MLH1 P40692 M481C 481 M C 0.032 Neutral MLH1 P40692 M481D 481 M D 0.066 Neutral MLH1 P40692 M481E 481 M E 0.008 Neutral MLH1 P40692 M481F 481 M F 0.23 Neutral MLH1 P40692 M481G 481 M G 0.11 Neutral MLH1 P40692 M481H 481 M H 0.01 Neutral MLH1 P40692 M481I 481 M I 0.016 Neutral MLH1 P40692 M481K 481 M K 0.03 Neutral MLH1 P40692 M481L 481 M L 0.004 Neutral MLH1 P40692 M481N 481 M N 0.058 Neutral MLH1 P40692 M481P 481 M P 0.036 Neutral MLH1 P40692 M481Q 481 M Q 0.002 Neutral MLH1 P40692 M481R 481 M R 0.05 Neutral MLH1 P40692 M481S 481 M S 0.01 Neutral MLH1 P40692 M481T 481 M T 0.008 Neutral MLH1 P40692 M481V 481 M V 0.018 Neutral MLH1 P40692 M481W 481 M W 0.492 Neutral MLH1 P40692 M481Y 481 M Y 0.404 Neutral MLH1 P40692 V482A 482 V A 0 Neutral MLH1 P40692 V482C 482 V C 0.056 Neutral MLH1 P40692 V482D 482 V D 0.034 Neutral MLH1 P40692 V482E 482 V E 0.044 Neutral MLH1 P40692 V482F 482 V F 0.142 Neutral MLH1 P40692 V482G 482 V G 0.118 Neutral MLH1 P40692 V482H 482 V H 0.048 Neutral MLH1 P40692 V482I 482 V I 0.002 Neutral MLH1 P40692 V482K 482 V K 0.064 Neutral MLH1 P40692 V482L 482 V L 0 Neutral MLH1 P40692 V482M 482 V M 0.014 Neutral MLH1 P40692 V482N 482 V N 0.038 Neutral MLH1 P40692 V482P 482 V P 0.038 Neutral MLH1 P40692 V482Q 482 V Q 0.05 Neutral MLH1 P40692 V482R 482 V R 0.226 Neutral MLH1 P40692 V482S 482 V S 0.01 Neutral MLH1 P40692 V482T 482 V T 0.008 Neutral MLH1 P40692 V482W 482 V W 0.344 Neutral MLH1 P40692 V482Y 482 V Y 0.16 Neutral MLH1 P40692 E483A 483 E A 0.138 Neutral MLH1 P40692 E483C 483 E C 0.124 Neutral MLH1 P40692 E483D 483 E D 0.002 Neutral MLH1 P40692 E483F 483 E F 0.43 Neutral MLH1 P40692 E483G 483 E G 0 Neutral MLH1 P40692 E483H 483 E H 0.17 Neutral MLH1 P40692 E483I 483 E I 0.328 Neutral MLH1 P40692 E483K 483 E K 0.002 Neutral MLH1 P40692 E483L 483 E L 0.452 Neutral MLH1 P40692 E483M 483 E M 0.294 Neutral MLH1 P40692 E483N 483 E N 0.01 Neutral MLH1 P40692 E483P 483 E P 0.07 Neutral MLH1 P40692 E483Q 483 E Q 0 Neutral MLH1 P40692 E483R 483 E R 0.02 Neutral MLH1 P40692 E483S 483 E S 0.016 Neutral MLH1 P40692 E483T 483 E T 0.012 Neutral MLH1 P40692 E483V 483 E V 0.044 Neutral MLH1 P40692 E483W 483 E W 0.702 Pathogenic MLH1 P40692 E483Y 483 E Y 0.654 Pathogenic MLH1 P40692 D484A 484 D A 0.118 Neutral MLH1 P40692 D484C 484 D C 0.256 Neutral MLH1 P40692 D484E 484 D E 0.012 Neutral MLH1 P40692 D484F 484 D F 0.62 Pathogenic MLH1 P40692 D484G 484 D G 0.092 Neutral MLH1 P40692 D484H 484 D H 0.154 Neutral MLH1 P40692 D484I 484 D I 0.15 Neutral MLH1 P40692 D484K 484 D K 0.02 Neutral MLH1 P40692 D484L 484 D L 0.424 Neutral MLH1 P40692 D484M 484 D M 0.332 Neutral MLH1 P40692 D484N 484 D N 0 Neutral MLH1 P40692 D484P 484 D P 0.444 Neutral MLH1 P40692 D484Q 484 D Q 0.234 Neutral MLH1 P40692 D484R 484 D R 0.252 Neutral MLH1 P40692 D484S 484 D S 0.002 Neutral MLH1 P40692 D484T 484 D T 0.022 Neutral MLH1 P40692 D484V 484 D V 0.138 Neutral MLH1 P40692 D484W 484 D W 0.706 Pathogenic MLH1 P40692 D484Y 484 D Y 0.678 Pathogenic MLH1 P40692 D485A 485 D A 0.014 Neutral MLH1 P40692 D485C 485 D C 0.148 Neutral MLH1 P40692 D485E 485 D E 0.014 Neutral MLH1 P40692 D485F 485 D F 0.296 Neutral MLH1 P40692 D485G 485 D G 0.018 Neutral MLH1 P40692 D485H 485 D H 0.106 Neutral MLH1 P40692 D485I 485 D I 0.116 Neutral MLH1 P40692 D485K 485 D K 0.02 Neutral MLH1 P40692 D485L 485 D L 0.026 Neutral MLH1 P40692 D485M 485 D M 0.19 Neutral MLH1 P40692 D485N 485 D N 0 Neutral MLH1 P40692 D485P 485 D P 0.31 Neutral MLH1 P40692 D485Q 485 D Q 0.078 Neutral MLH1 P40692 D485R 485 D R 0.128 Neutral MLH1 P40692 D485S 485 D S 0.002 Neutral MLH1 P40692 D485T 485 D T 0.012 Neutral MLH1 P40692 D485V 485 D V 0.07 Neutral MLH1 P40692 D485W 485 D W 0.434 Neutral MLH1 P40692 D485Y 485 D Y 0.432 Neutral MLH1 P40692 S486A 486 S A 0.018 Neutral MLH1 P40692 S486C 486 S C 0.032 Neutral MLH1 P40692 S486D 486 S D 0.024 Neutral MLH1 P40692 S486E 486 S E 0.122 Neutral MLH1 P40692 S486F 486 S F 0.25 Neutral MLH1 P40692 S486G 486 S G 0.01 Neutral MLH1 P40692 S486H 486 S H 0.238 Neutral MLH1 P40692 S486I 486 S I 0.196 Neutral MLH1 P40692 S486K 486 S K 0.164 Neutral MLH1 P40692 S486L 486 S L 0.032 Neutral MLH1 P40692 S486M 486 S M 0.332 Neutral MLH1 P40692 S486N 486 S N 0 Neutral MLH1 P40692 S486P 486 S P 0.066 Neutral MLH1 P40692 S486Q 486 S Q 0.17 Neutral MLH1 P40692 S486R 486 S R 0.17 Neutral MLH1 P40692 S486T 486 S T 0.02 Neutral MLH1 P40692 S486V 486 S V 0.248 Neutral MLH1 P40692 S486W 486 S W 0.49 Neutral MLH1 P40692 S486Y 486 S Y 0.448 Neutral MLH1 P40692 R487A 487 R A 0.086 Neutral MLH1 P40692 R487C 487 R C 0.148 Neutral MLH1 P40692 R487D 487 R D 0.02 Neutral MLH1 P40692 R487E 487 R E 0.086 Neutral MLH1 P40692 R487F 487 R F 0.28 Neutral MLH1 P40692 R487G 487 R G 0.002 Neutral MLH1 P40692 R487H 487 R H 0.142 Neutral MLH1 P40692 R487I 487 R I 0.308 Neutral MLH1 P40692 R487K 487 R K 0.078 Neutral MLH1 P40692 R487L 487 R L 0.272 Neutral MLH1 P40692 R487M 487 R M 0.164 Neutral MLH1 P40692 R487N 487 R N 0.01 Neutral MLH1 P40692 R487P 487 R P 0.236 Neutral MLH1 P40692 R487Q 487 R Q 0.01 Neutral MLH1 P40692 R487S 487 R S 0.016 Neutral MLH1 P40692 R487T 487 R T 0.016 Neutral MLH1 P40692 R487V 487 R V 0.178 Neutral MLH1 P40692 R487W 487 R W 0.384 Neutral MLH1 P40692 R487Y 487 R Y 0.284 Neutral MLH1 P40692 K488A 488 K A 0.054 Neutral MLH1 P40692 K488C 488 K C 0.028 Neutral MLH1 P40692 K488D 488 K D 0.002 Neutral MLH1 P40692 K488E 488 K E 0.004 Neutral MLH1 P40692 K488F 488 K F 0.212 Neutral MLH1 P40692 K488G 488 K G 0.042 Neutral MLH1 P40692 K488H 488 K H 0.01 Neutral MLH1 P40692 K488I 488 K I 0.19 Neutral MLH1 P40692 K488L 488 K L 0.148 Neutral MLH1 P40692 K488M 488 K M 0.106 Neutral MLH1 P40692 K488N 488 K N 0.046 Neutral MLH1 P40692 K488P 488 K P 0.03 Neutral MLH1 P40692 K488Q 488 K Q 0.006 Neutral MLH1 P40692 K488R 488 K R 0.016 Neutral MLH1 P40692 K488S 488 K S 0.012 Neutral MLH1 P40692 K488T 488 K T 0.092 Neutral MLH1 P40692 K488V 488 K V 0.026 Neutral MLH1 P40692 K488W 488 K W 0.396 Neutral MLH1 P40692 K488Y 488 K Y 0.326 Neutral MLH1 P40692 E489A 489 E A 0.16 Neutral MLH1 P40692 E489C 489 E C 0.096 Neutral MLH1 P40692 E489D 489 E D 0.002 Neutral MLH1 P40692 E489F 489 E F 0.352 Neutral MLH1 P40692 E489G 489 E G 0.002 Neutral MLH1 P40692 E489H 489 E H 0.136 Neutral MLH1 P40692 E489I 489 E I 0.372 Neutral MLH1 P40692 E489K 489 E K 0.212 Neutral MLH1 P40692 E489L 489 E L 0.094 Neutral MLH1 P40692 E489M 489 E M 0.22 Neutral MLH1 P40692 E489N 489 E N 0.004 Neutral MLH1 P40692 E489P 489 E P 0.156 Neutral MLH1 P40692 E489Q 489 E Q 0.026 Neutral MLH1 P40692 E489R 489 E R 0.012 Neutral MLH1 P40692 E489S 489 E S 0.022 Neutral MLH1 P40692 E489T 489 E T 0.012 Neutral MLH1 P40692 E489V 489 E V 0.324 Neutral MLH1 P40692 E489W 489 E W 0.616 Pathogenic MLH1 P40692 E489Y 489 E Y 0.494 Neutral MLH1 P40692 V49A 49 V A 0.32 Neutral MLH1 P40692 V49C 49 V C 0.678 Pathogenic MLH1 P40692 V49D 49 V D 0.858 Pathogenic MLH1 P40692 V49E 49 V E 0.972 Pathogenic 5 MLH1 P40692 V49F 49 V F 0.856 Pathogenic MLH1 P40692 V49G 49 V G 0.484 Neutral MLH1 P40692 V49H 49 V H 0.788 Pathogenic MLH1 P40692 V49I 49 V I 0.13 Neutral MLH1 P40692 V49K 49 V K 0.952 Pathogenic MLH1 P40692 V49L 49 V L 0.218 Neutral MLH1 P40692 V49M 49 V M 0.402 Neutral MLH1 P40692 V49N 49 V N 0.928 Pathogenic MLH1 P40692 V49P 49 V P 0.95 Pathogenic MLH1 P40692 V49Q 49 V Q 0.986 Pathogenic MLH1 P40692 V49R 49 V R 0.956 Pathogenic MLH1 P40692 V49S 49 V S 0.728 Pathogenic MLH1 P40692 V49T 49 V T 0.72 Pathogenic MLH1 P40692 V49W 49 V W 0.896 Pathogenic MLH1 P40692 V49Y 49 V Y 0.918 Pathogenic MLH1 P40692 M490A 490 M A 0.112 Neutral MLH1 P40692 M490C 490 M C 0.076 Neutral MLH1 P40692 M490D 490 M D 0.236 Neutral MLH1 P40692 M490E 490 M E 0.068 Neutral MLH1 P40692 M490F 490 M F 0.358 Neutral MLH1 P40692 M490G 490 M G 0.182 Neutral MLH1 P40692 M490H 490 M H 0.016 Neutral MLH1 P40692 M490I 490 M I 0.012 Neutral MLH1 P40692 M490K 490 M K 0.024 Neutral MLH1 P40692 M490L 490 M L 0.008 Neutral MLH1 P40692 M490N 490 M N 0.276 Neutral MLH1 P40692 M490P 490 M P 0.424 Neutral MLH1 P40692 M490Q 490 M Q 0.102 Neutral MLH1 P40692 M490R 490 M R 0.054 Neutral MLH1 P40692 M490S 490 M S 0.024 Neutral MLH1 P40692 M490T 490 M T 0.098 Neutral MLH1 P40692 M490V 490 M V 0.094 Neutral MLH1 P40692 M490W 490 M W 0.682 Pathogenic MLH1 P40692 M490Y 490 M Y 0.146 Neutral MLH1 P40692 T491A 491 T A 0 Neutral MLH1 P40692 T491C 491 T C 0.114 Neutral MLH1 P40692 T491D 491 T D 0.028 Neutral MLH1 P40692 T491E 491 T E 0.036 Neutral MLH1 P40692 T491F 491 T F 0.398 Neutral MLH1 P40692 T491G 491 T G 0.06 Neutral MLH1 P40692 T491H 491 T H 0.184 Neutral MLH1 P40692 T491I 491 T I 0.182 Neutral MLH1 P40692 T491K 491 T K 0.012 Neutral MLH1 P40692 T491L 491 T L 0.16 Neutral MLH1 P40692 T491M 491 T M 0.12 Neutral MLH1 P40692 T491N 491 T N 0.016 Neutral MLH1 P40692 T491P 491 T P 0.032 Neutral MLH1 P40692 T491Q 491 T Q 0.004 Neutral MLH1 P40692 T491R 491 T R 0.23 Neutral MLH1 P40692 T491S 491 T S 0 Neutral MLH1 P40692 T491V 491 T V 0.334 Neutral MLH1 P40692 T491W 491 T W 0.708 Pathogenic MLH1 P40692 T491Y 491 T Y 0.51 Pathogenic MLH1 P40692 A492C 492 A C 0.362 Neutral MLH1 P40692 A492D 492 A D 0.444 Neutral MLH1 P40692 A492E 492 A E 0.374 Neutral MLH1 P40692 A492F 492 A F 0.376 Neutral MLH1 P40692 A492G 492 A G 0.228 Neutral MLH1 P40692 A492H 492 A H 0.51 Pathogenic MLH1 P40692 A492I 492 A I 0.454 Neutral MLH1 P40692 A492K 492 A K 0.558 Pathogenic MLH1 P40692 A492L 492 A L 0.392 Neutral MLH1 P40692 A492M 492 A M 0.462 Neutral MLH1 P40692 A492N 492 A N 0.49 Neutral MLH1 P40692 A492P 492 A P 0.06 Neutral MLH1 P40692 A492Q 492 A Q 0.342 Neutral MLH1 P40692 A492R 492 A R 0.382 Neutral MLH1 P40692 A492S 492 A S 0.008 Neutral MLH1 P40692 A492T 492 A T 0.024 Neutral MLH1 P40692 A492V 492 A V 0.058 Neutral MLH1 P40692 A492W 492 A W 0.556 Pathogenic MLH1 P40692 A492Y 492 A Y 0.744 Pathogenic MLH1 P40692 A493C 493 A C 0.1 Neutral MLH1 P40692 A493D 493 A D 0.446 Neutral MLH1 P40692 A493E 493 A E 0.486 Neutral MLH1 P40692 A493F 493 A F 0.656 Pathogenic MLH1 P40692 A493G 493 A G 0.028 Neutral MLH1 P40692 A493H 493 A H 0.492 Neutral MLH1 P40692 A493I 493 A I 0.45 Neutral MLH1 P40692 A493K 493 A K 0.424 Neutral MLH1 P40692 A493L 493 A L 0.404 Neutral MLH1 P40692 A493M 493 A M 0.34 Neutral MLH1 P40692 A493N 493 A N 0.43 Neutral MLH1 P40692 A493P 493 A P 0.488 Neutral MLH1 P40692 A493Q 493 A Q 0.476 Neutral MLH1 P40692 A493R 493 A R 0.568 Pathogenic MLH1 P40692 A493S 493 A S 0.004 Neutral MLH1 P40692 A493T 493 A T 0.02 Neutral MLH1 P40692 A493V 493 A V 0.052 Neutral MLH1 P40692 A493W 493 A W 0.746 Pathogenic MLH1 P40692 A493Y 493 A Y 0.75 Pathogenic MLH1 P40692 C494A 494 C A 0.004 Neutral MLH1 P40692 C494D 494 C D 0.012 Neutral MLH1 P40692 C494E 494 C E 0.036 Neutral MLH1 P40692 C494F 494 C F 0.444 Neutral MLH1 P40692 C494G 494 C G 0.004 Neutral MLH1 P40692 C494H 494 C H 0.228 Neutral MLH1 P40692 C494I 494 C I 0.084 Neutral MLH1 P40692 C494K 494 C K 0.042 Neutral MLH1 P40692 C494L 494 C L 0.316 Neutral MLH1 P40692 C494M 494 C M 0.152 Neutral MLH1 P40692 C494N 494 C N 0 Neutral MLH1 P40692 C494P 494 C P 0.034 Neutral MLH1 P40692 C494Q 494 C Q 0.008 Neutral MLH1 P40692 C494R 494 C R 0.228 Neutral MLH1 P40692 C494S 494 C S 0.016 Neutral MLH1 P40692 C494T 494 C T 0 Neutral MLH1 P40692 C494V 494 C V 0.016 Neutral MLH1 P40692 C494W 494 C W 0.522 Pathogenic MLH1 P40692 C494Y 494 C Y 0.484 Neutral MLH1 P40692 T495A 495 T A 0.002 Neutral MLH1 P40692 T495C 495 T C 0.004 Neutral MLH1 P40692 T495D 495 T D 0.058 Neutral MLH1 P40692 T495E 495 T E 0.062 Neutral MLH1 P40692 T495F 495 T F 0.21 Neutral MLH1 P40692 T495G 495 T G 0.058 Neutral MLH1 P40692 T495H 495 T H 0.062 Neutral MLH1 P40692 T495I 495 T I 0.042 Neutral MLH1 P40692 T495K 495 T K 0.002 Neutral MLH1 P40692 T495L 495 T L 0.008 Neutral MLH1 P40692 T495M 495 T M 0.05 Neutral MLH1 P40692 T495N 495 T N 0.02 Neutral MLH1 P40692 T495P 495 T P 0.01 Neutral MLH1 P40692 T495Q 495 T Q 0.018 Neutral MLH1 P40692 T495R 495 T R 0.14 Neutral MLH1 P40692 T495S 495 T S 0.004 Neutral MLH1 P40692 T495V 495 T V 0.046 Neutral MLH1 P40692 T495W 495 T W 0.476 Neutral MLH1 P40692 T495Y 495 T Y 0.312 Neutral MLH1 P40692 P496A 496 P A 0.068 Neutral MLH1 P40692 P496C 496 P C 0.24 Neutral MLH1 P40692 P496D 496 P D 0.136 Neutral MLH1 P40692 P496E 496 P E 0.08 Neutral MLH1 P40692 P496F 496 P F 0.528 Pathogenic MLH1 P40692 P496G 496 P G 0.142 Neutral MLH1 P40692 P496H 496 P H 0.402 Neutral MLH1 P40692 P496I 496 P I 0.248 Neutral MLH1 P40692 P496K 496 P K 0.08 Neutral MLH1 P40692 P496L 496 P L 0.174 Neutral 1 MLH1 P40692 P496M 496 P M 0.384 Neutral MLH1 P40692 P496N 496 P N 0.048 Neutral MLH1 P40692 P496Q 496 P Q 0.08 Neutral MLH1 P40692 P496R 496 P R 0.342 Neutral MLH1 P40692 P496S 496 P S 0.288 Neutral MLH1 P40692 P496T 496 P T 0.124 Neutral MLH1 P40692 P496V 496 P V 0.176 Neutral MLH1 P40692 P496W 496 P W 0.626 Pathogenic MLH1 P40692 P496Y 496 P Y 0.558 Pathogenic MLH1 P40692 R497A 497 R A 0.132 Neutral MLH1 P40692 R497C 497 R C 0.04 Neutral MLH1 P40692 R497D 497 R D 0.024 Neutral MLH1 P40692 R497E 497 R E 0.034 Neutral MLH1 P40692 R497F 497 R F 0.44 Neutral MLH1 P40692 R497G 497 R G 0.102 Neutral MLH1 P40692 R497H 497 R H 0.216 Neutral MLH1 P40692 R497I 497 R I 0.478 Neutral MLH1 P40692 R497K 497 R K 0.006 Neutral MLH1 P40692 R497L 497 R L 0.44 Neutral MLH1 P40692 R497M 497 R M 0.258 Neutral MLH1 P40692 R497N 497 R N 0.254 Neutral MLH1 P40692 R497P 497 R P 0.42 Neutral MLH1 P40692 R497Q 497 R Q 0.012 Neutral MLH1 P40692 R497S 497 R S 0.22 Neutral MLH1 P40692 R497T 497 R T 0.232 Neutral MLH1 P40692 R497V 497 R V 0.388 Neutral MLH1 P40692 R497W 497 R W 0.628 Pathogenic MLH1 P40692 R497Y 497 R Y 0.456 Neutral MLH1 P40692 R498A 498 R A 0.152 Neutral MLH1 P40692 R498C 498 R C 0.244 Neutral MLH1 P40692 R498D 498 R D 0.264 Neutral MLH1 P40692 R498E 498 R E 0.276 Neutral MLH1 P40692 R498F 498 R F 0.47 Neutral MLH1 P40692 R498G 498 R G 0.098 Neutral MLH1 P40692 R498H 498 R H 0.186 Neutral MLH1 P40692 R498I 498 R I 0.498 Neutral MLH1 P40692 R498K 498 R K 0.006 Neutral MLH1 P40692 R498L 498 R L 0.428 Neutral MLH1 P40692 R498M 498 R M 0.258 Neutral MLH1 P40692 R498N 498 R N 0.318 Neutral MLH1 P40692 R498P 498 R P 0.43 Neutral MLH1 P40692 R498Q 498 R Q 0.242 Neutral MLH1 P40692 R498S 498 R S 0.018 Neutral MLH1 P40692 R498T 498 R T 0.022 Neutral MLH1 P40692 R498V 498 R V 0.346 Neutral MLH1 P40692 R498W 498 R W 0.622 Pathogenic MLH1 P40692 R498Y 498 R Y 0.464 Neutral MLH1 P40692 R499A 499 R A 0.05 Neutral MLH1 P40692 R499C 499 R C 0.274 Neutral MLH1 P40692 R499D 499 R D 0.302 Neutral MLH1 P40692 R499E 499 R E 0.132 Neutral MLH1 P40692 R499F 499 R F 0.472 Neutral MLH1 P40692 R499G 499 R G 0.098 Neutral MLH1 P40692 R499H 499 R H 0.186 Neutral MLH1 P40692 R499I 499 R I 0.514 Pathogenic MLH1 P40692 R499K 499 R K 0.142 Neutral MLH1 P40692 R499L 499 R L 0.456 Neutral MLH1 P40692 R499M 499 R M 0.258 Neutral MLH1 P40692 R499N 499 R N 0.262 Neutral MLH1 P40692 R499P 499 R P 0.432 Neutral MLH1 P40692 R499Q 499 R Q 0.242 Neutral MLH1 P40692 R499S 499 R S 0.258 Neutral MLH1 P40692 R499T 499 R T 0.278 Neutral MLH1 P40692 R499V 499 R V 0.352 Neutral MLH1 P40692 R499W 499 R W 0.622 Pathogenic MLH1 P40692 R499Y 499 R Y 0.466 Neutral MLH1 P40692 A5C 5 A C 0.308 Neutral MLH1 P40692 A5D 5 A D 0.436 Neutral MLH1 P40692 A5E 5 A E 0.478 Neutral MLH1 P40692 A5F 5 A F 0.688 Pathogenic MLH1 P40692 A5G 5 A G 0.212 Neutral MLH1 P40692 A5H 5 A H 0.482 Neutral MLH1 P40692 A5I 5 A I 0.676 Pathogenic MLH1 P40692 A5K 5 A K 0.56 Pathogenic MLH1 P40692 A5L 5 A L 0.622 Pathogenic MLH1 P40692 A5M 5 A M 0.438 Neutral MLH1 P40692 A5N 5 A N 0.438 Neutral MLH1 P40692 A5P 5 A P 0.192 Neutral MLH1 P40692 A5Q 5 A Q 0.468 Neutral MLH1 P40692 A5R 5 A R 0.552 Pathogenic MLH1 P40692 A5S 5 A S 0.01 Neutral MLH1 P40692 A5T 5 A T 0.102 Neutral MLH1 P40692 A5V 5 A V 0.396 Neutral MLH1 P40692 A5W 5 A W 0.718 Pathogenic MLH1 P40692 A5Y 5 A Y 0.718 Pathogenic MLH1 P40692 I50A 50 I A 0.26 Neutral MLH1 P40692 I50C 50 I C 0.364 Neutral MLH1 P40692 I50D 50 I D 0.54 Pathogenic MLH1 P40692 I50E 50 I E 0.524 Pathogenic MLH1 P40692 I50F 50 I F 0.586 Pathogenic MLH1 P40692 I50G 50 I G 0.58 Pathogenic MLH1 P40692 I50H 50 I H 0.382 Neutral MLH1 P40692 I50K 50 I K 0.52 Pathogenic MLH1 P40692 I50L 50 I L 0.024 Neutral MLH1 P40692 I50M 50 I M 0.444 Neutral MLH1 P40692 I50N 50 I N 0.402 Neutral MLH1 P40692 I50P 50 I P 0.636 Pathogenic MLH1 P40692 I50Q 50 I Q 0.164 Neutral MLH1 P40692 I50R 50 I R 0.786 Pathogenic MLH1 P40692 I50S 50 I S 0.118 Neutral MLH1 P40692 I50T 50 I T 0.064 Neutral MLH1 P40692 I50V 50 I V 0.02 Neutral MLH1 P40692 I50W 50 I W 0.848 Pathogenic MLH1 P40692 I50Y 50 I Y 0.846 Pathogenic MLH1 P40692 I500A 500 I A 0.1 Neutral MLH1 P40692 I500C 500 I C 0.144 Neutral MLH1 P40692 I500D 500 I D 0.046 Neutral MLH1 P40692 I500E 500 I E 0.05 Neutral MLH1 P40692 I500F 500 I F 0.344 Neutral MLH1 P40692 I500G 500 I G 0.28 Neutral MLH1 P40692 I500H 500 I H 0.15 Neutral MLH1 P40692 I500K 500 I K 0.224 Neutral MLH1 P40692 I500L 500 I L 0.204 Neutral MLH1 P40692 I500M 500 I M 0.17 Neutral MLH1 P40692 I500N 500 I N 0.314 Neutral MLH1 P40692 I500P 500 I P 0.2 Neutral MLH1 P40692 I500Q 500 I Q 0.114 Neutral MLH1 P40692 I500R 500 I R 0.472 Neutral MLH1 P40692 I500S 500 I S 0.22 Neutral MLH1 P40692 I500T 500 I T 0.168 Neutral MLH1 P40692 I500V 500 I V 0.006 Neutral MLH1 P40692 I500W 500 I W 0.536 Pathogenic MLH1 P40692 I500Y 500 I Y 0.494 Neutral MLH1 P40692 I501A 501 I A 0.012 Neutral MLH1 P40692 I501C 501 I C 0.018 Neutral MLH1 P40692 I501D 501 I D 0.23 Neutral MLH1 P40692 I501E 501 I E 0.214 Neutral MLH1 P40692 I501F 501 I F 0.146 Neutral MLH1 P40692 I501G 501 I G 0.34 Neutral MLH1 P40692 I501H 501 I H 0.13 Neutral MLH1 P40692 I501K 501 I K 0.164 Neutral MLH1 P40692 I501L 501 I L 0.096 Neutral MLH1 P40692 I501M 501 I M 0.168 Neutral MLH1 P40692 I501N 501 I N 0.134 Neutral MLH1 P40692 I501P 501 I P 0.26 Neutral MLH1 P40692 I501Q 501 I Q 0.27 Neutral MLH1 P40692 I501R 501 I R 0.41 Neutral MLH1 P40692 I501S 501 I S 0.182 Neutral MLH1 P40692 I501T 501 I T 0.01 Neutral MLH1 P40692 I501V 501 I V 0.002 Neutral MLH1 P40692 I501W 501 I W 0.608 Pathogenic MLH1 P40692 I501Y 501 I Y 0.566 Pathogenic MLH1 P40692 N502A 502 N A 0.126 Neutral MLH1 P40692 N502C 502 N C 0.242 Neutral MLH1 P40692 N502D 502 N D 0.04 Neutral MLH1 P40692 N502E 502 N E 0.02 Neutral MLH1 P40692 N502F 502 N F 0.674 Pathogenic MLH1 P40692 N502G 502 N G 0.244 Neutral MLH1 P40692 N502H 502 N H 0.09 Neutral MLH1 P40692 N502I 502 N I 0.52 Pathogenic MLH1 P40692 N502K 502 N K 0.036 Neutral MLH1 P40692 N502L 502 N L 0.448 Neutral MLH1 P40692 N502M 502 N M 0.37 Neutral MLH1 P40692 N502P 502 N P 0.404 Neutral MLH1 P40692 N502Q 502 N Q 0.02 Neutral MLH1 P40692 N502R 502 N R 0.252 Neutral MLH1 P40692 N502S 502 N S 0.03 Neutral MLH1 P40692 N502T 502 N T 0.112 Neutral MLH1 P40692 N502V 502 N V 0.462 Neutral MLH1 P40692 N502W 502 N W 0.722 Pathogenic MLH1 P40692 N502Y 502 N Y 0.668 Pathogenic MLH1 P40692 L503A 503 L A 0.32 Neutral MLH1 P40692 L503C 503 L C 0.41 Neutral MLH1 P40692 L503D 503 L D 0.68 Pathogenic MLH1 P40692 L503E 503 L E 0.636 Pathogenic MLH1 P40692 L503F 503 L F 0.276 Neutral MLH1 P40692 L503G 503 L G 0.446 Neutral MLH1 P40692 L503H 503 L H 0.434 Neutral MLH1 P40692 L503I 503 L I 0.584 Pathogenic MLH1 P40692 L503K 503 L K 0.484 Neutral MLH1 P40692 L503M 503 L M 0.468 Neutral MLH1 P40692 L503N 503 L N 0.626 Pathogenic MLH1 P40692 L503P 503 L P 0.95 Pathogenic MLH1 P40692 L503Q 503 L Q 0.372 Neutral MLH1 P40692 L503R 503 L R 0.872 Pathogenic MLH1 P40692 L503S 503 L S 0.398 Neutral MLH1 P40692 L503T 503 L T 0.36 Neutral MLH1 P40692 L503V 503 L V 0.422 Neutral MLH1 P40692 L503W 503 L W 0.846 Pathogenic MLH1 P40692 L503Y 503 L Y 0.652 Pathogenic MLH1 P40692 T504A 504 T A 0.366 Neutral MLH1 P40692 T504C 504 T C 0.49 Neutral MLH1 P40692 T504D 504 T D 0.22 Neutral MLH1 P40692 T504E 504 T E 0.184 Neutral MLH1 P40692 T504F 504 T F 0.734 Pathogenic MLH1 P40692 T504G 504 T G 0.292 Neutral MLH1 P40692 T504H 504 T H 0.578 Pathogenic MLH1 P40692 T504I 504 T I 0.468 Neutral MLH1 P40692 T504K 504 T K 0.142 Neutral MLH1 P40692 T504L 504 T L 0.206 Neutral MLH1 P40692 T504M 504 T M 0.676 Pathogenic MLH1 P40692 T504N 504 T N 0.186 Neutral MLH1 P40692 T504P 504 T P 0.636 Pathogenic MLH1 P40692 T504Q 504 T Q 0.136 Neutral MLH1 P40692 T504R 504 T R 0.602 Pathogenic MLH1 P40692 T504S 504 T S 0.038 Neutral MLH1 P40692 T504V 504 T V 0.754 Pathogenic MLH1 P40692 T504W 504 T W 0.94 Pathogenic MLH1 P40692 T504Y 504 T Y 0.934 Pathogenic MLH1 P40692 S505A 505 S A 0.75 Pathogenic MLH1 P40692 S505C 505 S C 0.78 Pathogenic MLH1 P40692 S505D 505 S D 0.804 Pathogenic MLH1 P40692 S505E 505 S E 0.91 Pathogenic MLH1 P40692 S505F 505 S F 0.828 Pathogenic MLH1 P40692 S505G 505 S G 0.546 Pathogenic MLH1 P40692 S505H 505 S H 0.924 Pathogenic MLH1 P40692 S505I 505 S I 0.856 Pathogenic MLH1 P40692 S505K 505 S K 0.898 Pathogenic MLH1 P40692 S505L 505 S L 0.882 Pathogenic MLH1 P40692 S505M 505 S M 0.998 Pathogenic MLH1 P40692 S505N 505 S N 0.766 Pathogenic MLH1 P40692 S505P 505 S P 0.918 Pathogenic MLH1 P40692 S505Q 505 S Q 0.588 Pathogenic MLH1 P40692 S505R 505 S R 0.93 Pathogenic MLH1 P40692 S505T 505 S T 0.33 Neutral MLH1 P40692 S505V 505 S V 0.96 Pathogenic MLH1 P40692 S505W 505 S W 0.984 Pathogenic MLH1 P40692 S505Y 505 S Y 0.98 Pathogenic MLH1 P40692 V506A 506 V A 0.154 Neutral MLH1 P40692 V506C 506 V C 0.42 Neutral MLH1 P40692 V506D 506 V D 0.612 Pathogenic MLH1 P40692 V506E 506 V E 0.714 Pathogenic MLH1 P40692 V506F 506 V F 0.77 Pathogenic MLH1 P40692 V506G 506 V G 0.452 Neutral MLH1 P40692 V506H 506 V H 0.562 Pathogenic MLH1 P40692 V506I 506 V I 0.058 Neutral MLH1 P40692 V506K 506 V K 0.788 Pathogenic MLH1 P40692 V506L 506 V L 0.078 Neutral MLH1 P40692 V506M 506 V M 0.52 Pathogenic MLH1 P40692 V506N 506 V N 0.652 Pathogenic MLH1 P40692 V506P 506 V P 0.85 Pathogenic MLH1 P40692 V506Q 506 V Q 0.73 Pathogenic MLH1 P40692 V506R 506 V R 0.834 Pathogenic MLH1 P40692 V506S 506 V S 0.464 Neutral MLH1 P40692 V506T 506 V T 0.424 Neutral MLH1 P40692 V506W 506 V W 0.846 Pathogenic MLH1 P40692 V506Y 506 V Y 0.838 Pathogenic MLH1 P40692 L507A 507 L A 0.046 Neutral MLH1 P40692 L507C 507 L C 0.31 Neutral MLH1 P40692 L507D 507 L D 0.614 Pathogenic MLH1 P40692 L507E 507 L E 0.13 Neutral MLH1 P40692 L507F 507 L F 0.708 Pathogenic MLH1 P40692 L507G 507 L G 0.566 Pathogenic MLH1 P40692 L507H 507 L H 0.054 Neutral MLH1 P40692 L507I 507 L I 0.332 Neutral MLH1 P40692 L507K 507 L K 0.044 Neutral MLH1 P40692 L507M 507 L M 0.23 Neutral MLH1 P40692 L507N 507 L N 0.572 Pathogenic MLH1 P40692 L507P 507 L P 0.806 Pathogenic MLH1 P40692 L507Q 507 L Q 0.038 Neutral MLH1 P40692 L507R 507 L R 0.51 Pathogenic MLH1 P40692 L507S 507 L S 0.058 Neutral MLH1 P40692 L507T 507 L T 0.524 Pathogenic MLH1 P40692 L507V 507 L V 0.258 Neutral MLH1 P40692 L507W 507 L W 0.81 Pathogenic MLH1 P40692 L507Y 507 L Y 0.832 Pathogenic MLH1 P40692 S508A 508 S A 0.01 Neutral MLH1 P40692 S508C 508 S C 0.076 Neutral MLH1 P40692 S508D 508 S D 0.006 Neutral MLH1 P40692 S508E 508 S E 0.254 Neutral MLH1 P40692 S508F 508 S F 0.544 Pathogenic MLH1 P40692 S508G 508 S G 0.088 Neutral MLH1 P40692 S508H 508 S H 0.398 Neutral MLH1 P40692 S508I 508 S I 0.184 Neutral MLH1 P40692 S508K 508 S K 0.268 Neutral MLH1 P40692 S508L 508 S L 0.184 Neutral MLH1 P40692 S508M 508 S M 0.648 Pathogenic MLH1 P40692 S508N 508 S N 0.006 Neutral MLH1 P40692 S508P 508 S P 0.224 Neutral MLH1 P40692 S508Q 508 S Q 0.286 Neutral MLH1 P40692 S508R 508 S R 0.254 Neutral MLH1 P40692 S508T 508 S T 0.018 Neutral MLH1 P40692 S508V 508 S V 0.414 Neutral MLH1 P40692 S508W 508 S W 0.772 Pathogenic MLH1 P40692 S508Y 508 S Y 0.728 Pathogenic MLH1 P40692 L509A 509 L A 0.56 Pathogenic MLH1 P40692 L509C 509 L C 0.682 Pathogenic MLH1 P40692 L509D 509 L D 0.894 Pathogenic MLH1 P40692 L509E 509 L E 0.876 Pathogenic MLH1 P40692 L509F 509 L F 0.974 Pathogenic MLH1 P40692 L509G 509 L G 0.796 Pathogenic MLH1 P40692 L509H 509 L H 0.798 Pathogenic MLH1 P40692 L509I 509 L I 0.432 Neutral MLH1 P40692 L509K 509 L K 0.744 Pathogenic MLH1 P40692 L509M 509 L M 0.262 Neutral MLH1 P40692 L509N 509 L N 0.762 Pathogenic MLH1 P40692 L509P 509 L P 0.998 Pathogenic MLH1 P40692 L509Q 509 L Q 0.614 Pathogenic MLH1 P40692 L509R 509 L R 0.988 Pathogenic MLH1 P40692 L509S 509 L S 0.608 Pathogenic MLH1 P40692 L509T 509 L T 0.58 Pathogenic MLH1 P40692 L509V 509 L V 0.302 Neutral MLH1 P40692 L509W 509 L W 0.94 Pathogenic MLH1 P40692 L509Y 509 L Y 0.902 Pathogenic MLH1 P40692 V51A 51 V A 0.086 Neutral MLH1 P40692 V51C 51 V C 0.34 Neutral MLH1 P40692 V51D 51 V D 0.854 Pathogenic MLH1 P40692 V51E 51 V E 0.958 Pathogenic MLH1 P40692 V51F 51 V F 0.828 Pathogenic MLH1 P40692 V51G 51 V G 0.522 Pathogenic MLH1 P40692 V51H 51 V H 0.764 Pathogenic MLH1 P40692 V51I 51 V I 0.178 Neutral MLH1 P40692 V51K 51 V K 0.934 Pathogenic MLH1 P40692 V51L 51 V L 0.192 Neutral MLH1 P40692 V51M 51 V M 0.742 Pathogenic MLH1 P40692 V51N 51 V N 0.924 Pathogenic MLH1 P40692 V51P 51 V P 0.942 Pathogenic MLH1 P40692 V51Q 51 V Q 0.974 Pathogenic MLH1 P40692 V51R 51 V R 0.95 Pathogenic MLH1 P40692 V51S 51 V S 0.71 Pathogenic MLH1 P40692 V51T 51 V T 0.164 Neutral MLH1 P40692 V51W 51 V W 0.876 Pathogenic MLH1 P40692 V51Y 51 V Y 0.892 Pathogenic MLH1 P40692 Q510A 510 Q A 0.41 Neutral MLH1 P40692 Q510C 510 Q C 0.3 Neutral MLH1 P40692 Q510D 510 Q D 0.414 Neutral MLH1 P40692 Q510E 510 Q E 0.514 Pathogenic MLH1 P40692 Q510F 510 Q F 0.764 Pathogenic MLH1 P40692 Q510G 510 Q G 0.436 Neutral MLH1 P40692 Q510H 510 Q H 0.788 Pathogenic MLH1 P40692 Q510I 510 Q I 0.312 Neutral MLH1 P40692 Q510K 510 Q K 0.042 Neutral MLH1 P40692 Q510L 510 Q L 0.176 Neutral MLH1 P40692 Q510M 510 Q M 0.668 Pathogenic MLH1 P40692 Q510N 510 Q N 0.446 Neutral MLH1 P40692 Q510P 510 Q P 0.824 Pathogenic MLH1 P40692 Q510R 510 Q R 0.054 Neutral MLH1 P40692 Q510S 510 Q S 0.09 Neutral MLH1 P40692 Q510T 510 Q T 0.302 Neutral MLH1 P40692 Q510V 510 Q V 0.202 Neutral MLH1 P40692 Q510W 510 Q W 0.89 Pathogenic MLH1 P40692 Q510Y 510 Q Y 0.844 Pathogenic MLH1 P40692 E511A 511 E A 0.102 Neutral MLH1 P40692 E511C 511 E C 0.126 Neutral MLH1 P40692 E511D 511 E D 0.002 Neutral MLH1 P40692 E511F 511 E F 0.438 Neutral MLH1 P40692 E511G 511 E G 0.074 Neutral MLH1 P40692 E511H 511 E H 0.288 Neutral MLH1 P40692 E511I 511 E I 0.474 Neutral MLH1 P40692 E511K 511 E K 0.002 Neutral MLH1 P40692 E511L 511 E L 0.466 Neutral MLH1 P40692 E511M 511 E M 0.298 Neutral MLH1 P40692 E511N 511 E N 0.002 Neutral MLH1 P40692 E511P 511 E P 0.488 Neutral MLH1 P40692 E511Q 511 E Q 0 Neutral MLH1 P40692 E511R 511 E R 0.024 Neutral MLH1 P40692 E511S 511 E S 0.018 Neutral MLH1 P40692 E511T 511 E T 0.014 Neutral MLH1 P40692 E511V 511 E V 0.406 Neutral MLH1 P40692 E511W 511 E W 0.716 Pathogenic MLH1 P40692 E511Y 511 E Y 0.594 Pathogenic MLH1 P40692 E512A 512 E A 0.152 Neutral MLH1 P40692 E512C 512 E C 0.348 Neutral MLH1 P40692 E512D 512 E D 0.026 Neutral MLH1 P40692 E512F 512 E F 0.726 Pathogenic MLH1 P40692 E512G 512 E G 0.13 Neutral MLH1 P40692 E512H 512 E H 0.322 Neutral MLH1 P40692 E512I 512 E I 0.294 Neutral MLH1 P40692 E512K 512 E K 0.308 Neutral MLH1 P40692 E512L 512 E L 0.208 Neutral MLH1 P40692 E512M 512 E M 0.318 Neutral MLH1 P40692 E512N 512 E N 0.046 Neutral MLH1 P40692 E512P 512 E P 0.794 Pathogenic MLH1 P40692 E512Q 512 E Q 0.008 Neutral MLH1 P40692 E512R 512 E R 0.07 Neutral MLH1 P40692 E512S 512 E S 0.044 Neutral MLH1 P40692 E512T 512 E T 0.108 Neutral MLH1 P40692 E512V 512 E V 0.734 Pathogenic MLH1 P40692 E512W 512 E W 0.904 Pathogenic MLH1 P40692 E512Y 512 E Y 0.8 Pathogenic MLH1 P40692 I513A 513 I A 0.228 Neutral MLH1 P40692 I513C 513 I C 0.382 Neutral MLH1 P40692 I513D 513 I D 0.568 Pathogenic MLH1 P40692 I513E 513 I E 0.552 Pathogenic MLH1 P40692 I513F 513 I F 0.596 Pathogenic MLH1 P40692 I513G 513 I G 0.558 Pathogenic MLH1 P40692 I513H 513 I H 0.426 Neutral MLH1 P40692 I513K 513 I K 0.564 Pathogenic MLH1 P40692 I513L 513 I L 0.03 Neutral MLH1 P40692 I513M 513 I M 0.104 Neutral MLH1 P40692 I513N 513 I N 0.612 Pathogenic MLH1 P40692 I513P 513 I P 0.698 Pathogenic MLH1 P40692 I513Q 513 I Q 0.59 Pathogenic MLH1 P40692 I513R 513 I R 0.822 Pathogenic MLH1 P40692 I513S 513 I S 0.424 Neutral MLH1 P40692 I513T 513 I T 0.054 Neutral MLH1 P40692 I513V 513 I V 0.02 Neutral MLH1 P40692 I513W 513 I W 0.896 Pathogenic MLH1 P40692 I513Y 513 I Y 0.902 Pathogenic MLH1 P40692 N514A 514 N A 0.166 Neutral MLH1 P40692 N514C 514 N C 0.026 Neutral MLH1 P40692 N514D 514 N D 0.01 Neutral MLH1 P40692 N514E 514 N E 0.018 Neutral MLH1 P40692 N514F 514 N F 0.582 Pathogenic MLH1 P40692 N514G 514 N G 0.218 Neutral MLH1 P40692 N514H 514 N H 0.36 Neutral MLH1 P40692 N514I 514 N I 0.334 Neutral MLH1 P40692 N514K 514 N K 0.044 Neutral MLH1 P40692 N514L 514 N L 0.478 Neutral MLH1 P40692 N514M 514 N M 0.362 Neutral MLH1 P40692 N514P 514 N P 0.386 Neutral MLH1 P40692 N514Q 514 N Q 0.048 Neutral MLH1 P40692 N514R 514 N R 0.252 Neutral MLH1 P40692 N514S 514 N S 0.008 Neutral MLH1 P40692 N514T 514 N T 0.012 Neutral MLH1 P40692 N514V 514 N V 0.096 Neutral MLH1 P40692 N514W 514 N W 0.71 Pathogenic MLH1 P40692 N514Y 514 N Y 0.666 Pathogenic MLH1 P40692 E515A 515 E A 0.076 Neutral MLH1 P40692 E515C 515 E C 0.116 Neutral MLH1 P40692 E515D 515 E D 0.002 Neutral MLH1 P40692 E515F 515 E F 0.422 Neutral MLH1 P40692 E515G 515 E G 0.002 Neutral MLH1 P40692 E515H 515 E H 0.158 Neutral MLH1 P40692 E515I 515 E I 0.45 Neutral MLH1 P40692 E515K 515 E K 0.002 Neutral MLH1 P40692 E515L 515 E L 0.208 Neutral MLH1 P40692 E515M 515 E M 0.29 Neutral MLH1 P40692 E515N 515 E N 0.002 Neutral MLH1 P40692 E515P 515 E P 0.462 Neutral MLH1 P40692 E515Q 515 E Q 0 Neutral MLH1 P40692 E515R 515 E R 0.02 Neutral MLH1 P40692 E515S 515 E S 0.016 Neutral MLH1 P40692 E515T 515 E T 0.248 Neutral MLH1 P40692 E515V 515 E V 0.4 Neutral MLH1 P40692 E515W 515 E W 0.694 Pathogenic MLH1 P40692 E515Y 515 E Y 0.58 Pathogenic MLH1 P40692 Q516A 516 Q A 0.05 Neutral MLH1 P40692 Q516C 516 Q C 0.096 Neutral MLH1 P40692 Q516D 516 Q D 0.004 Neutral MLH1 P40692 Q516E 516 Q E 0.014 Neutral MLH1 P40692 Q516F 516 Q F 0.348 Neutral MLH1 P40692 Q516G 516 Q G 0.178 Neutral MLH1 P40692 Q516H 516 Q H 0.34 Neutral MLH1 P40692 Q516I 516 Q I 0.26 Neutral MLH1 P40692 Q516K 516 Q K 0.03 Neutral MLH1 P40692 Q516L 516 Q L 0.38 Neutral MLH1 P40692 Q516M 516 Q M 0.314 Neutral MLH1 P40692 Q516N 516 Q N 0.026 Neutral MLH1 P40692 Q516P 516 Q P 0.444 Neutral MLH1 P40692 Q516R 516 Q R 0.018 Neutral MLH1 P40692 Q516S 516 Q S 0.048 Neutral MLH1 P40692 Q516T 516 Q T 0.01 Neutral MLH1 P40692 Q516V 516 Q V 0.152 Neutral MLH1 P40692 Q516W 516 Q W 0.668 Pathogenic MLH1 P40692 Q516Y 516 Q Y 0.598 Pathogenic MLH1 P40692 G517A 517 G A 0.008 Neutral MLH1 P40692 G517C 517 G C 0.278 Neutral MLH1 P40692 G517D 517 G D 0.434 Neutral MLH1 P40692 G517E 517 G E 0.302 Neutral MLH1 P40692 G517F 517 G F 0.772 Pathogenic MLH1 P40692 G517H 517 G H 0.716 Pathogenic MLH1 P40692 G517I 517 G I 0.516 Pathogenic MLH1 P40692 G517K 517 G K 0.392 Neutral MLH1 P40692 G517L 517 G L 0.688 Pathogenic MLH1 P40692 G517M 517 G M 0.39 Neutral MLH1 P40692 G517N 517 G N 0.334 Neutral MLH1 P40692 G517P 517 G P 0.646 Pathogenic MLH1 P40692 G517Q 517 G Q 0.28 Neutral MLH1 P40692 G517R 517 G R 0.418 Neutral MLH1 P40692 G517S 517 G S 0.022 Neutral MLH1 P40692 G517T 517 G T 0.356 Neutral MLH1 P40692 G517V 517 G V 0.428 Neutral MLH1 P40692 G517W 517 G W 0.77 Pathogenic MLH1 P40692 G517Y 517 G Y 0.734 Pathogenic MLH1 P40692 H518A 518 H A 0.208 Neutral MLH1 P40692 H518C 518 H C 0.466 Neutral MLH1 P40692 H518D 518 H D 0.096 Neutral MLH1 P40692 H518E 518 H E 0.598 Pathogenic MLH1 P40692 H518F 518 H F 0.748 Pathogenic MLH1 P40692 H518G 518 H G 0.5 Pathogenic MLH1 P40692 H518I 518 H I 0.796 Pathogenic MLH1 P40692 H518K 518 H K 0.61 Pathogenic MLH1 P40692 H518L 518 H L 0.728 Pathogenic MLH1 P40692 H518M 518 H M 0.626 Pathogenic MLH1 P40692 H518N 518 H N 0.088 Neutral MLH1 P40692 H518P 518 H P 0.922 Pathogenic MLH1 P40692 H518Q 518 H Q 0.248 Neutral MLH1 P40692 H518R 518 H R 0.652 Pathogenic MLH1 P40692 H518S 518 H S 0.154 Neutral MLH1 P40692 H518T 518 H T 0.336 Neutral MLH1 P40692 H518V 518 H V 0.512 Pathogenic MLH1 P40692 H518W 518 H W 0.922 Pathogenic MLH1 P40692 H518Y 518 H Y 0.764 Pathogenic MLH1 P40692 E519A 519 E A 0.078 Neutral MLH1 P40692 E519C 519 E C 0.13 Neutral MLH1 P40692 E519D 519 E D 0.016 Neutral MLH1 P40692 E519F 519 E F 0.44 Neutral MLH1 P40692 E519G 519 E G 0.03 Neutral MLH1 P40692 E519H 519 E H 0.022 Neutral MLH1 P40692 E519I 519 E I 0.334 Neutral MLH1 P40692 E519K 519 E K 0.008 Neutral MLH1 P40692 E519L 519 E L 0.21 Neutral MLH1 P40692 E519M 519 E M 0.302 Neutral MLH1 P40692 E519N 519 E N 0.004 Neutral MLH1 P40692 E519P 519 E P 0.074 Neutral MLH1 P40692 E519Q 519 E Q 0.002 Neutral MLH1 P40692 E519R 519 E R 0.024 Neutral MLH1 P40692 E519S 519 E S 0.02 Neutral MLH1 P40692 E519T 519 E T 0.014 Neutral MLH1 P40692 E519V 519 E V 0.1 Neutral MLH1 P40692 E519W 519 E W 0.712 Pathogenic MLH1 P40692 E519Y 519 E Y 0.662 Pathogenic MLH1 P40692 K52A 52 K A 0.546 Pathogenic MLH1 P40692 K52C 52 K C 0.434 Neutral MLH1 P40692 K52D 52 K D 0.612 Pathogenic MLH1 P40692 K52E 52 K E 0.728 Pathogenic MLH1 P40692 K52F 52 K F 0.966 Pathogenic MLH1 P40692 K52G 52 K G 0.212 Neutral MLH1 P40692 K52H 52 K H 0.75 Pathogenic MLH1 P40692 K52I 52 K I 0.984 Pathogenic MLH1 P40692 K52L 52 K L 0.974 Pathogenic MLH1 P40692 K52M 52 K M 0.916 Pathogenic MLH1 P40692 K52N 52 K N 0.658 Pathogenic MLH1 P40692 K52P 52 K P 0.918 Pathogenic MLH1 P40692 K52Q 52 K Q 0.296 Neutral MLH1 P40692 K52R 52 K R 0.152 Neutral MLH1 P40692 K52S 52 K S 0.148 Neutral MLH1 P40692 K52T 52 K T 0.302 Neutral MLH1 P40692 K52V 52 K V 0.876 Pathogenic MLH1 P40692 K52W 52 K W 0.992 Pathogenic MLH1 P40692 K52Y 52 K Y 0.986 Pathogenic MLH1 P40692 V520A 520 V A 0.002 Neutral MLH1 P40692 V520C 520 V C 0.084 Neutral MLH1 P40692 V520D 520 V D 0.034 Neutral MLH1 P40692 V520E 520 V E 0.06 Neutral MLH1 P40692 V520F 520 V F 0.294 Neutral MLH1 P40692 V520G 520 V G 0.042 Neutral MLH1 P40692 V520H 520 V H 0.22 Neutral MLH1 P40692 V520I 520 V I 0.128 Neutral MLH1 P40692 V520K 520 V K 0.074 Neutral MLH1 P40692 V520L 520 V L 0.034 Neutral MLH1 P40692 V520M 520 V M 0.114 Neutral MLH1 P40692 V520N 520 V N 0.046 Neutral MLH1 P40692 V520P 520 V P 0.048 Neutral MLH1 P40692 V520Q 520 V Q 0.064 Neutral MLH1 P40692 V520R 520 V R 0.3 Neutral MLH1 P40692 V520S 520 V S 0.016 Neutral MLH1 P40692 V520T 520 V T 0.01 Neutral MLH1 P40692 V520W 520 V W 0.518 Pathogenic MLH1 P40692 V520Y 520 V Y 0.438 Neutral MLH1 P40692 L521A 521 L A 0.158 Neutral MLH1 P40692 L521C 521 L C 0.164 Neutral MLH1 P40692 L521D 521 L D 0.352 Neutral MLH1 P40692 L521E 521 L E 0.284 Neutral MLH1 P40692 L521F 521 L F 0.452 Neutral MLH1 P40692 L521G 521 L G 0.324 Neutral MLH1 P40692 L521H 521 L H 0.152 Neutral MLH1 P40692 L521I 521 L I 0.122 Neutral MLH1 P40692 L521K 521 L K 0.238 Neutral MLH1 P40692 L521M 521 L M 0.262 Neutral MLH1 P40692 L521N 521 L N 0.302 Neutral MLH1 P40692 L521P 521 L P 0.412 Neutral MLH1 P40692 L521Q 521 L Q 0.13 Neutral MLH1 P40692 L521R 521 L R 0.592 Pathogenic MLH1 P40692 L521S 521 L S 0.254 Neutral MLH1 P40692 L521T 521 L T 0.36 Neutral MLH1 P40692 L521V 521 L V 0.262 Neutral MLH1 P40692 L521W 521 L W 0.626 Pathogenic MLH1 P40692 L521Y 521 L Y 0.584 Pathogenic MLH1 P40692 R522A 522 R A 0.15 Neutral MLH1 P40692 R522C 522 R C 0.25 Neutral MLH1 P40692 R522D 522 R D 0.266 Neutral MLH1 P40692 R522E 522 R E 0.208 Neutral MLH1 P40692 R522F 522 R F 0.46 Neutral MLH1 P40692 R522G 522 R G 0.106 Neutral MLH1 P40692 R522H 522 R H 0.22 Neutral MLH1 P40692 R522I 522 R I 0.482 Neutral MLH1 P40692 R522K 522 R K 0.01 Neutral MLH1 P40692 R522L 522 R L 0.444 Neutral MLH1 P40692 R522M 522 R M 0.262 Neutral MLH1 P40692 R522N 522 R N 0.258 Neutral MLH1 P40692 R522P 522 R P 0.424 Neutral MLH1 P40692 R522Q 522 R Q 0.014 Neutral MLH1 P40692 R522S 522 R S 0.21 Neutral MLH1 P40692 R522T 522 R T 0.236 Neutral MLH1 P40692 R522V 522 R V 0.314 Neutral MLH1 P40692 R522W 522 R W 0.706 Pathogenic MLH1 P40692 R522Y 522 R Y 0.46 Neutral MLH1 P40692 E523A 523 E A 0.346 Neutral MLH1 P40692 E523C 523 E C 0.48 Neutral MLH1 P40692 E523D 523 E D 0.018 Neutral MLH1 P40692 E523F 523 E F 0.882 Pathogenic MLH1 P40692 E523G 523 E G 0.036 Neutral MLH1 P40692 E523H 523 E H 0.642 Pathogenic MLH1 P40692 E523I 523 E I 0.94 Pathogenic MLH1 P40692 E523K 523 E K 0.04 Neutral MLH1 P40692 E523L 523 E L 0.162 Neutral MLH1 P40692 E523M 523 E M 0.726 Pathogenic MLH1 P40692 E523N 523 E N 0.014 Neutral MLH1 P40692 E523P 523 E P 0.89 Pathogenic MLH1 P40692 E523Q 523 E Q 0.02 Neutral MLH1 P40692 E523R 523 E R 0.122 Neutral MLH1 P40692 E523S 523 E S 0.052 Neutral MLH1 P40692 E523T 523 E T 0.122 Neutral MLH1 P40692 E523V 523 E V 0.85 Pathogenic MLH1 P40692 E523W 523 E W 0.97 Pathogenic MLH1 P40692 E523Y 523 E Y 0.92 Pathogenic MLH1 P40692 M524A 524 M A 0.27 Neutral MLH1 P40692 M524C 524 M C 0.188 Neutral MLH1 P40692 M524D 524 M D 0.538 Pathogenic MLH1 P40692 M524E 524 M E 0.362 Neutral MLH1 P40692 M524F 524 M F 0.412 Neutral MLH1 P40692 M524G 524 M G 0.322 Neutral MLH1 P40692 M524H 524 M H 0.054 Neutral MLH1 P40692 M524I 524 M I 0.048 Neutral MLH1 P40692 M524K 524 M K 0.616 Pathogenic MLH1 P40692 M524L 524 M L 0.042 Neutral MLH1 P40692 M524N 524 M N 0.122 Neutral MLH1 P40692 M524P 524 M P 0.862 Pathogenic MLH1 P40692 M524Q 524 M Q 0.09 Neutral MLH1 P40692 M524R 524 M R 0.5 Pathogenic MLH1 P40692 M524S 524 M S 0.19 Neutral MLH1 P40692 M524T 524 M T 0.03 Neutral MLH1 P40692 M524V 524 M V 0.058 Neutral MLH1 P40692 M524W 524 M W 0.96 Pathogenic MLH1 P40692 M524Y 524 M Y 0.872 Pathogenic MLH1 P40692 L525A 525 L A 0.32 Neutral MLH1 P40692 L525C 525 L C 0.028 Neutral MLH1 P40692 L525D 525 L D 0.508 Pathogenic MLH1 P40692 L525E 525 L E 0.634 Pathogenic MLH1 P40692 L525F 525 L F 0.302 Neutral MLH1 P40692 L525G 525 L G 0.58 Pathogenic MLH1 P40692 L525H 525 L H 0.164 Neutral MLH1 P40692 L525I 525 L I 0.038 Neutral MLH1 P40692 L525K 525 L K 0.48 Neutral MLH1 P40692 L525M 525 L M 0.132 Neutral MLH1 P40692 L525N 525 L N 0.622 Pathogenic MLH1 P40692 L525P 525 L P 0.946 Pathogenic MLH1 P40692 L525Q 525 L Q 0.372 Neutral MLH1 P40692 L525R 525 L R 0.87 Pathogenic MLH1 P40692 L525S 525 L S 0.39 Neutral MLH1 P40692 L525T 525 L T 0.376 Neutral MLH1 P40692 L525V 525 L V 0.002 Neutral MLH1 P40692 L525W 525 L W 0.84 Pathogenic MLH1 P40692 L525Y 525 L Y 0.832 Pathogenic MLH1 P40692 H526A 526 H A 0.066 Neutral MLH1 P40692 H526C 526 H C 0.118 Neutral MLH1 P40692 H526D 526 H D 0.122 Neutral MLH1 P40692 H526E 526 H E 0.004 Neutral MLH1 P40692 H526F 526 H F 0.49 Neutral MLH1 P40692 H526G 526 H G 0.29 Neutral MLH1 P40692 H526I 526 H I 0.548 Pathogenic MLH1 P40692 H526K 526 H K 0.01 Neutral MLH1 P40692 H526L 526 H L 0.226 Neutral MLH1 P40692 H526M 526 H M 0.338 Neutral MLH1 P40692 H526N 526 H N 0.006 Neutral MLH1 P40692 H526P 526 H P 0.634 Pathogenic MLH1 P40692 H526Q 526 H Q 0.008 Neutral MLH1 P40692 H526R 526 H R 0.008 Neutral MLH1 P40692 H526S 526 H S 0.02 Neutral MLH1 P40692 H526T 526 H T 0.014 Neutral MLH1 P40692 H526V 526 H V 0.384 Neutral MLH1 P40692 H526W 526 H W 0.776 Pathogenic MLH1 P40692 H526Y 526 H Y 0.594 Pathogenic MLH1 P40692 N527A 527 N A 0.376 Neutral MLH1 P40692 N527C 527 N C 0.56 Pathogenic MLH1 P40692 N527D 527 N D 0.038 Neutral MLH1 P40692 N527E 527 N E 0.046 Neutral MLH1 P40692 N527F 527 N F 0.902 Pathogenic MLH1 P40692 N527G 527 N G 0.046 Neutral MLH1 P40692 N527H 527 N H 0.204 Neutral MLH1 P40692 N527I 527 N I 0.832 Pathogenic MLH1 P40692 N527K 527 N K 0.08 Neutral MLH1 P40692 N527L 527 N L 0.83 Pathogenic MLH1 P40692 N527M 527 N M 0.784 Pathogenic MLH1 P40692 N527P 527 N P 0.728 Pathogenic MLH1 P40692 N527Q 527 N Q 0.02 Neutral MLH1 P40692 N527R 527 N R 0.412 Neutral MLH1 P40692 N527S 527 N S 0.02 Neutral MLH1 P40692 N527T 527 N T 0.05 Neutral MLH1 P40692 N527V 527 N V 0.86 Pathogenic MLH1 P40692 N527W 527 N W 0.93 Pathogenic MLH1 P40692 N527Y 527 N Y 0.938 Pathogenic MLH1 P40692 H528A 528 H A 0.166 Neutral MLH1 P40692 H528C 528 H C 0.138 Neutral MLH1 P40692 H528D 528 H D 0.452 Neutral MLH1 P40692 H528E 528 H E 0.192 Neutral MLH1 P40692 H528F 528 H F 0.386 Neutral MLH1 P40692 H528G 528 H G 0.5 Pathogenic MLH1 P40692 H528I 528 H I 0.796 Pathogenic MLH1 P40692 H528K 528 H K 0.612 Pathogenic MLH1 P40692 H528L 528 H L 0.326 Neutral MLH1 P40692 H528M 528 H M 0.206 Neutral MLH1 P40692 H528N 528 H N 0.174 Neutral MLH1 P40692 H528P 528 H P 0.692 Pathogenic MLH1 P40692 H528Q 528 H Q 0.64 Pathogenic MLH1 P40692 H528R 528 H R 0.652 Pathogenic MLH1 P40692 H528S 528 H S 0.154 Neutral MLH1 P40692 H528T 528 H T 0.588 Pathogenic MLH1 P40692 H528V 528 H V 0.514 Pathogenic MLH1 P40692 H528W 528 H W 0.922 Pathogenic MLH1 P40692 H528Y 528 H Y 0.388 Neutral MLH1 P40692 S529A 529 S A 0.14 Neutral MLH1 P40692 S529C 529 S C 0.352 Neutral MLH1 P40692 S529D 529 S D 0.54 Pathogenic MLH1 P40692 S529E 529 S E 0.754 Pathogenic MLH1 P40692 S529F 529 S F 0.894 Pathogenic MLH1 P40692 S529G 529 S G 0.204 Neutral MLH1 P40692 S529H 529 S H 0.814 Pathogenic MLH1 P40692 S529I 529 S I 0.342 Neutral MLH1 P40692 S529K 529 S K 0.45 Neutral MLH1 P40692 S529L 529 S L 0.644 Pathogenic MLH1 P40692 S529M 529 S M 0.98 Pathogenic MLH1 P40692 S529N 529 S N 0.214 Neutral MLH1 P40692 S529P 529 S P 0.502 Pathogenic MLH1 P40692 S529Q 529 S Q 0.582 Pathogenic MLH1 P40692 S529R 529 S R 0.822 Pathogenic MLH1 P40692 S529T 529 S T 0.234 Neutral MLH1 P40692 S529V 529 S V 0.082 Neutral MLH1 P40692 S529W 529 S W 0.952 Pathogenic MLH1 P40692 S529Y 529 S Y 0.934 Pathogenic MLH1 P40692 E53A 53 E A 0.122 Neutral MLH1 P40692 E53C 53 E C 0.068 Neutral MLH1 P40692 E53D 53 E D 0 Neutral MLH1 P40692 E53F 53 E F 0.296 Neutral MLH1 P40692 E53G 53 E G 0.054 Neutral MLH1 P40692 E53H 53 E H 0.108 Neutral MLH1 P40692 E53I 53 E I 0.31 Neutral MLH1 P40692 E53K 53 E K 0.168 Neutral MLH1 P40692 E53L 53 E L 0.308 Neutral MLH1 P40692 E53M 53 E M 0.176 Neutral MLH1 P40692 E53N 53 E N 0.036 Neutral MLH1 P40692 E53P 53 E P 0.322 Neutral MLH1 P40692 E53Q 53 E Q 0.018 Neutral MLH1 P40692 E53R 53 E R 0.048 Neutral MLH1 P40692 E53S 53 E S 0.158 Neutral MLH1 P40692 E53T 53 E T 0.144 Neutral MLH1 P40692 E53V 53 E V 0.272 Neutral MLH1 P40692 E53W 53 E W 0.508 Pathogenic MLH1 P40692 E53Y 53 E Y 0.404 Neutral MLH1 P40692 F530A 530 F A 0.458 Neutral MLH1 P40692 F530C 530 F C 0.634 Pathogenic MLH1 P40692 F530D 530 F D 0.75 Pathogenic MLH1 P40692 F530E 530 F E 0.816 Pathogenic MLH1 P40692 F530G 530 F G 0.464 Neutral MLH1 P40692 F530H 530 F H 0.68 Pathogenic MLH1 P40692 F530I 530 F I 0.602 Pathogenic MLH1 P40692 F530K 530 F K 0.8 Pathogenic MLH1 P40692 F530L 530 F L 0.168 Neutral MLH1 P40692 F530M 530 F M 0.706 Pathogenic MLH1 P40692 F530N 530 F N 0.666 Pathogenic MLH1 P40692 F530P 530 F P 0.93 Pathogenic MLH1 P40692 F530Q 530 F Q 0.69 Pathogenic MLH1 P40692 F530R 530 F R 0.88 Pathogenic MLH1 P40692 F530S 530 F S 0.76 Pathogenic MLH1 P40692 F530T 530 F T 0.552 Pathogenic MLH1 P40692 F530V 530 F V 0.42 Neutral MLH1 P40692 F530W 530 F W 0.752 Pathogenic MLH1 P40692 F530Y 530 F Y 0.266 Neutral MLH1 P40692 V531A 531 V A 0.5 Pathogenic MLH1 P40692 V531C 531 V C 0.796 Pathogenic MLH1 P40692 V531D 531 V D 0.85 Pathogenic MLH1 P40692 V531E 531 V E 0.954 Pathogenic MLH1 P40692 V531F 531 V F 0.932 Pathogenic MLH1 P40692 V531G 531 V G 0.926 Pathogenic MLH1 P40692 V531H 531 V H 0.896 Pathogenic MLH1 P40692 V531I 531 V I 0.268 Neutral MLH1 P40692 V531K 531 V K 0.97 Pathogenic MLH1 P40692 V531L 531 V L 0.566 Pathogenic MLH1 P40692 V531M 531 V M 0.904 Pathogenic MLH1 P40692 V531N 531 V N 0.91 Pathogenic MLH1 P40692 V531P 531 V P 0.984 Pathogenic MLH1 P40692 V531Q 531 V Q 0.962 Pathogenic MLH1 P40692 V531R 531 V R 0.946 Pathogenic MLH1 P40692 V531S 531 V S 0.804 Pathogenic MLH1 P40692 V531T 531 V T 0.408 Neutral MLH1 P40692 V531W 531 V W 0.956 Pathogenic MLH1 P40692 V531Y 531 V Y 0.976 Pathogenic MLH1 P40692 G532A 532 G A 0.652 Pathogenic MLH1 P40692 G532C 532 G C 0.934 Pathogenic MLH1 P40692 G532D 532 G D 0.992 Pathogenic MLH1 P40692 G532E 532 G E 0.976 Pathogenic MLH1 P40692 G532F 532 G F 0.972 Pathogenic MLH1 P40692 G532H 532 G H 0.976 Pathogenic MLH1 P40692 G532I 532 G I 0.964 Pathogenic MLH1 P40692 G532K 532 G K 0.976 Pathogenic MLH1 P40692 G532L 532 G L 0.974 Pathogenic MLH1 P40692 G532M 532 G M 0.988 Pathogenic MLH1 P40692 G532N 532 G N 0.978 Pathogenic MLH1 P40692 G532P 532 G P 0.934 Pathogenic MLH1 P40692 G532Q 532 G Q 0.986 Pathogenic MLH1 P40692 G532R 532 G R 0.994 Pathogenic MLH1 P40692 G532S 532 G S 0.492 Neutral MLH1 P40692 G532T 532 G T 0.8 Pathogenic MLH1 P40692 G532V 532 G V 0.974 Pathogenic MLH1 P40692 G532W 532 G W 0.968 Pathogenic MLH1 P40692 G532Y 532 G Y 0.93 Pathogenic MLH1 P40692 C533A 533 C A 0.074 Neutral MLH1 P40692 C533D 533 C D 0.564 Pathogenic MLH1 P40692 C533E 533 C E 0.622 Pathogenic MLH1 P40692 C533F 533 C F 0.65 Pathogenic MLH1 P40692 C533G 533 C G 0.534 Pathogenic MLH1 P40692 C533H 533 C H 0.764 Pathogenic MLH1 P40692 C533I 533 C I 0.128 Neutral MLH1 P40692 C533K 533 C K 0.682 Pathogenic MLH1 P40692 C533L 533 C L 0.09 Neutral MLH1 P40692 C533M 533 C M 0.092 Neutral MLH1 P40692 C533N 533 C N 0.032 Neutral MLH1 P40692 C533P 533 C P 0.898 Pathogenic MLH1 P40692 C533Q 533 C Q 0.518 Pathogenic MLH1 P40692 C533R 533 C R 0.914 Pathogenic MLH1 P40692 C533S 533 C S 0.04 Neutral MLH1 P40692 C533T 533 C T 0.028 Neutral MLH1 P40692 C533V 533 C V 0.056 Neutral MLH1 P40692 C533W 533 C W 0.954 Pathogenic MLH1 P40692 C533Y 533 C Y 0.96 Pathogenic MLH1 P40692 V534A 534 V A 0.068 Neutral MLH1 P40692 V534C 534 V C 0.724 Pathogenic MLH1 P40692 V534D 534 V D 0.864 Pathogenic MLH1 P40692 V534E 534 V E 0.978 Pathogenic MLH1 P40692 V534F 534 V F 0.89 Pathogenic MLH1 P40692 V534G 534 V G 0.89 Pathogenic MLH1 P40692 V534H 534 V H 0.834 Pathogenic MLH1 P40692 V534I 534 V I 0.174 Neutral MLH1 P40692 V534K 534 V K 0.99 Pathogenic MLH1 P40692 V534L 534 V L 0.304 Neutral MLH1 P40692 V534M 534 V M 0.834 Pathogenic MLH1 P40692 V534N 534 V N 0.924 Pathogenic MLH1 P40692 V534P 534 V P 0.984 Pathogenic MLH1 P40692 V534Q 534 V Q 0.984 Pathogenic MLH1 P40692 V534R 534 V R 0.952 Pathogenic MLH1 P40692 V534S 534 V S 0.728 Pathogenic MLH1 P40692 V534T 534 V T 0.324 Neutral MLH1 P40692 V534W 534 V W 0.918 Pathogenic MLH1 P40692 V534Y 534 V Y 0.946 Pathogenic MLH1 P40692 N535A 535 N A 0.59 Pathogenic MLH1 P40692 N535C 535 N C 0.516 Pathogenic MLH1 P40692 N535D 535 N D 0.368 Neutral MLH1 P40692 N535E 535 N E 0.202 Neutral MLH1 P40692 N535F 535 N F 0.898 Pathogenic MLH1 P40692 N535G 535 N G 0.64 Pathogenic MLH1 P40692 N535H 535 N H 0.742 Pathogenic MLH1 P40692 N535I 535 N I 0.878 Pathogenic MLH1 P40692 N535K 535 N K 0.416 Neutral MLH1 P40692 N535L 535 N L 0.868 Pathogenic MLH1 P40692 N535M 535 N M 0.85 Pathogenic MLH1 P40692 N535P 535 N P 0.732 Pathogenic MLH1 P40692 N535Q 535 N Q 0.67 Pathogenic MLH1 P40692 N535R 535 N R 0.81 Pathogenic MLH1 P40692 N535S 535 N S 0.186 Neutral MLH1 P40692 N535T 535 N T 0.182 Neutral MLH1 P40692 N535V 535 N V 0.914 Pathogenic MLH1 P40692 N535W 535 N W 0.914 Pathogenic MLH1 P40692 N535Y 535 N Y 0.906 Pathogenic MLH1 P40692 P536A 536 P A 0.162 Neutral MLH1 P40692 P536C 536 P C 0.252 Neutral MLH1 P40692 P536D 536 P D 0.014 Neutral MLH1 P40692 P536E 536 P E 0.08 Neutral MLH1 P40692 P536F 536 P F 0.558 Pathogenic MLH1 P40692 P536G 536 P G 0.146 Neutral MLH1 P40692 P536H 536 P H 0.378 Neutral MLH1 P40692 P536I 536 P I 0.176 Neutral MLH1 P40692 P536K 536 P K 0.174 Neutral MLH1 P40692 P536L 536 P L 0.072 Neutral MLH1 P40692 P536M 536 P M 0.396 Neutral MLH1 P40692 P536N 536 P N 0.1 Neutral MLH1 P40692 P536Q 536 P Q 0.08 Neutral MLH1 P40692 P536R 536 P R 0.342 Neutral MLH1 P40692 P536S 536 P S 0.296 Neutral MLH1 P40692 P536T 536 P T 0.31 Neutral MLH1 P40692 P536V 536 P V 0.226 Neutral MLH1 P40692 P536W 536 P W 0.65 Pathogenic MLH1 P40692 P536Y 536 P Y 0.588 Pathogenic MLH1 P40692 Q537A 537 Q A 0.426 Neutral MLH1 P40692 Q537C 537 Q C 0.018 Neutral MLH1 P40692 Q537D 537 Q D 0.038 Neutral MLH1 P40692 Q537E 537 Q E 0.024 Neutral MLH1 P40692 Q537F 537 Q F 0.756 Pathogenic MLH1 P40692 Q537G 537 Q G 0.112 Neutral MLH1 P40692 Q537H 537 Q H 0.078 Neutral MLH1 P40692 Q537I 537 Q I 0.85 Pathogenic MLH1 P40692 Q537K 537 Q K 0.06 Neutral MLH1 P40692 Q537L 537 Q L 0.166 Neutral MLH1 P40692 Q537M 537 Q M 0.666 Pathogenic MLH1 P40692 Q537N 537 Q N 0.378 Neutral MLH1 P40692 Q537P 537 Q P 0.812 Pathogenic MLH1 P40692 Q537R 537 Q R 0.046 Neutral MLH1 P40692 Q537S 537 Q S 0.076 Neutral MLH1 P40692 Q537T 537 Q T 0.02 Neutral MLH1 P40692 Q537V 537 Q V 0.79 Pathogenic MLH1 P40692 Q537W 537 Q W 0.886 Pathogenic MLH1 P40692 Q537Y 537 Q Y 0.836 Pathogenic MLH1 P40692 W538A 538 W A 0.302 Neutral MLH1 P40692 W538C 538 W C 0.302 Neutral MLH1 P40692 W538D 538 W D 0.346 Neutral MLH1 P40692 W538E 538 W E 0.498 Neutral MLH1 P40692 W538F 538 W F 0.064 Neutral MLH1 P40692 W538G 538 W G 0.272 Neutral MLH1 P40692 W538H 538 W H 0.106 Neutral MLH1 P40692 W538I 538 W I 0.156 Neutral MLH1 P40692 W538K 538 W K 0.386 Neutral MLH1 P40692 W538L 538 W L 0.152 Neutral MLH1 P40692 W538M 538 W M 0.266 Neutral MLH1 P40692 W538N 538 W N 0.278 Neutral MLH1 P40692 W538P 538 W P 0.306 Neutral MLH1 P40692 W538Q 538 W Q 0.216 Neutral MLH1 P40692 W538R 538 W R 0.088 Neutral MLH1 P40692 W538S 538 W S 0.21 Neutral MLH1 P40692 W538T 538 W T 0.25 Neutral MLH1 P40692 W538V 538 W V 0.218 Neutral MLH1 P40692 W538Y 538 W Y 0.046 Neutral MLH1 P40692 A539C 539 A C 0.316 Neutral MLH1 P40692 A539D 539 A D 0.816 Pathogenic MLH1 P40692 A539E 539 A E 0.85 Pathogenic MLH1 P40692 A539F 539 A F 0.916 Pathogenic MLH1 P40692 A539G 539 A G 0.34 Neutral MLH1 P40692 A539H 539 A H 0.812 Pathogenic MLH1 P40692 A539I 539 A I 0.898 Pathogenic MLH1 P40692 A539K 539 A K 0.722 Pathogenic MLH1 P40692 A539L 539 A L 0.716 Pathogenic MLH1 P40692 A539M 539 A M 0.762 Pathogenic MLH1 P40692 A539N 539 A N 0.772 Pathogenic MLH1 P40692 A539P 539 A P 0.896 Pathogenic MLH1 P40692 A539Q 539 A Q 0.798 Pathogenic MLH1 P40692 A539R 539 A R 0.87 Pathogenic MLH1 P40692 A539S 539 A S 0.114 Neutral MLH1 P40692 A539T 539 A T 0.172 Neutral MLH1 P40692 A539V 539 A V 0.374 Neutral MLH1 P40692 A539W 539 A W 0.916 Pathogenic MLH1 P40692 A539Y 539 A Y 0.888 Pathogenic MLH1 P40692 G54A 54 G A 0.15 Neutral MLH1 P40692 G54C 54 G C 0.354 Neutral MLH1 P40692 G54D 54 G D 0.424 Neutral MLH1 P40692 G54E 54 G E 0.562 Pathogenic 5 MLH1 P40692 G54F 54 G F 0.756 Pathogenic MLH1 P40692 G54H 54 G H 0.698 Pathogenic MLH1 P40692 G54I 54 G I 0.676 Pathogenic MLH1 P40692 G54K 54 G K 0.622 Pathogenic MLH1 P40692 G54L 54 G L 0.676 Pathogenic MLH1 P40692 G54M 54 G M 0.688 Pathogenic MLH1 P40692 G54N 54 G N 0.418 Neutral MLH1 P40692 G54P 54 G P 0.636 Pathogenic MLH1 P40692 G54Q 54 G Q 0.452 Neutral MLH1 P40692 G54R 54 G R 0.744 Pathogenic MLH1 P40692 G54S 54 G S 0.29 Neutral MLH1 P40692 G54T 54 G T 0.468 Neutral MLH1 P40692 G54V 54 G V 0.658 Pathogenic MLH1 P40692 G54W 54 G W 0.754 Pathogenic MLH1 P40692 G54Y 54 G Y 0.738 Pathogenic MLH1 P40692 L540A 540 L A 0.094 Neutral MLH1 P40692 L540C 540 L C 0.098 Neutral MLH1 P40692 L540D 540 L D 0.914 Pathogenic MLH1 P40692 L540E 540 L E 0.892 Pathogenic MLH1 P40692 L540F 540 L F 0.876 Pathogenic MLH1 P40692 L540G 540 L G 0.804 Pathogenic MLH1 P40692 L540H 540 L H 0.772 Pathogenic MLH1 P40692 L540I 540 L I 0.394 Neutral MLH1 P40692 L540K 540 L K 0.694 Pathogenic MLH1 P40692 L540M 540 L M 0.236 Neutral MLH1 P40692 L540N 540 L N 0.786 Pathogenic MLH1 P40692 L540P 540 L P 0.972 Pathogenic MLH1 P40692 L540Q 540 L Q 0.606 Pathogenic MLH1 P40692 L540R 540 L R 0.996 Pathogenic MLH1 P40692 L540S 540 L S 0.13 Neutral MLH1 P40692 L540T 540 L T 0.174 Neutral MLH1 P40692 L540V 540 L V 0.086 Neutral MLH1 P40692 L540W 540 L W 0.868 Pathogenic MLH1 P40692 L540Y 540 L Y 0.828 Pathogenic MLH1 P40692 A541C 541 A C 0.662 Pathogenic MLH1 P40692 A541D 541 A D 0.858 Pathogenic MLH1 P40692 A541E 541 A E 0.88 Pathogenic MLH1 P40692 A541F 541 A F 0.56 Pathogenic MLH1 P40692 A541G 541 A G 0.508 Pathogenic MLH1 P40692 A541H 541 A H 0.87 Pathogenic MLH1 P40692 A541I 541 A I 0.658 Pathogenic MLH1 P40692 A541K 541 A K 0.914 Pathogenic MLH1 P40692 A541L 541 A L 0.58 Pathogenic MLH1 P40692 A541M 541 A M 0.568 Pathogenic MLH1 P40692 A541N 541 A N 0.768 Pathogenic MLH1 P40692 A541P 541 A P 0.918 Pathogenic MLH1 P40692 A541Q 541 A Q 0.79 Pathogenic MLH1 P40692 A541R 541 A R 0.924 Pathogenic MLH1 P40692 A541S 541 A S 0.422 Neutral MLH1 P40692 A541T 541 A T 0.64 Pathogenic MLH1 P40692 A541V 541 A V 0.134 Neutral MLH1 P40692 A541W 541 A W 0.958 Pathogenic MLH1 P40692 A541Y 541 A Y 0.944 Pathogenic MLH1 P40692 Q542A 542 Q A 0.776 Pathogenic MLH1 P40692 Q542C 542 Q C 0.75 Pathogenic MLH1 P40692 Q542D 542 Q D 0.842 Pathogenic MLH1 P40692 Q542E 542 Q E 0.274 Neutral MLH1 P40692 Q542F 542 Q F 0.902 Pathogenic MLH1 P40692 Q542G 542 Q G 0.526 Pathogenic MLH1 P40692 Q542H 542 Q H 0.878 Pathogenic MLH1 P40692 Q542I 542 Q I 0.932 Pathogenic MLH1 P40692 Q542K 542 Q K 0.668 Pathogenic MLH1 P40692 Q542L 542 Q L 0.834 Pathogenic MLH1 P40692 Q542M 542 Q M 0.87 Pathogenic MLH1 P40692 Q542N 542 Q N 0.878 Pathogenic MLH1 P40692 Q542P 542 Q P 0.898 Pathogenic MLH1 P40692 Q542R 542 Q R 0.916 Pathogenic MLH1 P40692 Q542S 542 Q S 0.63 Pathogenic MLH1 P40692 Q542T 542 Q T 0.438 Neutral MLH1 P40692 Q542V 542 Q V 0.908 Pathogenic MLH1 P40692 Q542W 542 Q W 0.938 Pathogenic MLH1 P40692 Q542Y 542 Q Y 0.928 Pathogenic MLH1 P40692 H543A 543 H A 0.146 Neutral MLH1 P40692 H543C 543 H C 0.022 Neutral MLH1 P40692 H543D 543 H D 0.258 Neutral MLH1 P40692 H543E 543 H E 0.078 Neutral MLH1 P40692 H543F 543 H F 0.078 Neutral MLH1 P40692 H543G 543 H G 0.088 Neutral MLH1 P40692 H543I 543 H I 0.78 Pathogenic MLH1 P40692 H543K 543 H K 0.558 Pathogenic MLH1 P40692 H543L 543 H L 0.728 Pathogenic MLH1 P40692 H543M 543 H M 0.624 Pathogenic MLH1 P40692 H543N 543 H N 0.096 Neutral MLH1 P40692 H543P 543 H P 0.906 Pathogenic MLH1 P40692 H543Q 543 H Q 0.156 Neutral MLH1 P40692 H543R 543 H R 0.166 Neutral MLH1 P40692 H543S 543 H S 0.03 Neutral MLH1 P40692 H543T 543 H T 0.46 Neutral MLH1 P40692 H543V 543 H V 0.534 Pathogenic MLH1 P40692 H543W 543 H W 0.954 Pathogenic MLH1 P40692 H543Y 543 H Y 0.106 Neutral MLH1 P40692 Q544A 544 Q A 0.426 Neutral MLH1 P40692 Q544C 544 Q C 0.394 Neutral MLH1 P40692 Q544D 544 Q D 0.016 Neutral MLH1 P40692 Q544E 544 Q E 0.02 Neutral MLH1 P40692 Q544F 544 Q F 0.84 Pathogenic MLH1 P40692 Q544G 544 Q G 0.094 Neutral MLH1 P40692 Q544H 544 Q H 0.072 Neutral MLH1 P40692 Q544I 544 Q I 0.8 Pathogenic MLH1 P40692 Q544K 544 Q K 0.06 Neutral MLH1 P40692 Q544L 544 Q L 0.268 Neutral MLH1 P40692 Q544M 544 Q M 0.666 Pathogenic MLH1 P40692 Q544N 544 Q N 0.058 Neutral MLH1 P40692 Q544P 544 Q P 0.814 Pathogenic MLH1 P40692 Q544R 544 Q R 0.034 Neutral MLH1 P40692 Q544S 544 Q S 0.076 Neutral MLH1 P40692 Q544T 544 Q T 0.508 Pathogenic MLH1 P40692 Q544V 544 Q V 0.79 Pathogenic MLH1 P40692 Q544W 544 Q W 0.886 Pathogenic MLH1 P40692 Q544Y 544 Q Y 0.836 Pathogenic MLH1 P40692 T545A 545 T A 0.256 Neutral MLH1 P40692 T545C 545 T C 0.806 Pathogenic MLH1 P40692 T545D 545 T D 0.82 Pathogenic MLH1 P40692 T545E 545 T E 0.608 Pathogenic MLH1 P40692 T545F 545 T F 0.906 Pathogenic MLH1 P40692 T545G 545 T G 0.57 Pathogenic MLH1 P40692 T545H 545 T H 0.832 Pathogenic MLH1 P40692 T545I 545 T I 0.434 Neutral MLH1 P40692 T545K 545 T K 0.384 Neutral MLH1 P40692 T545L 545 T L 0.274 Neutral MLH1 P40692 T545M 545 T M 0.944 Pathogenic MLH1 P40692 T545N 545 T N 0.734 Pathogenic MLH1 P40692 T545P 545 T P 0.43 Neutral MLH1 P40692 T545Q 545 T Q 0.31 Neutral MLH1 P40692 T545R 545 T R 0.696 Pathogenic MLH1 P40692 T545S 545 T S 0.21 Neutral MLH1 P40692 T545V 545 T V 0.302 Neutral MLH1 P40692 T545W 545 T W 0.98 Pathogenic MLH1 P40692 T545Y 545 T Y 0.98 Pathogenic MLH1 P40692 K546A 546 K A 0.486 Neutral MLH1 P40692 K546C 546 K C 0.116 Neutral MLH1 P40692 K546D 546 K D 0.134 Neutral MLH1 P40692 K546E 546 K E 0.104 Neutral MLH1 P40692 K546F 546 K F 0.8 Pathogenic MLH1 P40692 K546G 546 K G 0.166 Neutral MLH1 P40692 K546H 546 K H 0.08 Neutral MLH1 P40692 K546I 546 K I 0.96 Pathogenic MLH1 P40692 K546L 546 K L 0.942 Pathogenic MLH1 P40692 K546M 546 K M 0.764 Pathogenic MLH1 P40692 K546N 546 K N 0.096 Neutral MLH1 P40692 K546P 546 K P 0.85 Pathogenic MLH1 P40692 K546Q 546 K Q 0.098 Neutral MLH1 P40692 K546R 546 K R 0.118 Neutral MLH1 P40692 K546S 546 K S 0.134 Neutral MLH1 P40692 K546T 546 K T 0.49 Neutral MLH1 P40692 K546V 546 K V 0.798 Pathogenic MLH1 P40692 K546W 546 K W 0.966 Pathogenic MLH1 P40692 K546Y 546 K Y 0.944 Pathogenic MLH1 P40692 L547A 547 L A 0.702 Pathogenic MLH1 P40692 L547C 547 L C 0.806 Pathogenic MLH1 P40692 L547D 547 L D 0.876 Pathogenic MLH1 P40692 L547E 547 L E 0.858 Pathogenic MLH1 P40692 L547F 547 L F 0.828 Pathogenic MLH1 P40692 L547G 547 L G 0.846 Pathogenic MLH1 P40692 L547H 547 L H 0.898 Pathogenic MLH1 P40692 L547I 547 L I 0.302 Neutral MLH1 P40692 L547K 547 L K 0.674 Pathogenic MLH1 P40692 L547M 547 L M 0.152 Neutral MLH1 P40692 L547N 547 L N 0.494 Neutral MLH1 P40692 L547P 547 L P 0.97 Pathogenic MLH1 P40692 L547Q 547 L Q 0.748 Pathogenic MLH1 P40692 L547R 547 L R 0.97 Pathogenic MLH1 P40692 L547S 547 L S 0.656 Pathogenic MLH1 P40692 L547T 547 L T 0.576 Pathogenic MLH1 P40692 L547V 547 L V 0.33 Neutral MLH1 P40692 L547W 547 L W 0.848 Pathogenic MLH1 P40692 L547Y 547 L Y 0.87 Pathogenic MLH1 P40692 Y548A 548 Y A 0.334 Neutral MLH1 P40692 Y548C 548 Y C 0.544 Pathogenic MLH1 P40692 Y548D 548 Y D 0.792 Pathogenic MLH1 P40692 Y548E 548 Y E 0.71 Pathogenic MLH1 P40692 Y548F 548 Y F 0.064 Neutral MLH1 P40692 Y548G 548 Y G 0.236 Neutral MLH1 P40692 Y548H 548 Y H 0.084 Neutral MLH1 P40692 Y548I 548 Y I 0.258 Neutral MLH1 P40692 Y548K 548 Y K 0.42 Neutral MLH1 P40692 Y548L 548 Y L 0.124 Neutral MLH1 P40692 Y548M 548 Y M 0.586 Pathogenic MLH1 P40692 Y548N 548 Y N 0.618 Pathogenic MLH1 P40692 Y548P 548 Y P 0.704 Pathogenic MLH1 P40692 Y548Q 548 Y Q 0.53 Pathogenic MLH1 P40692 Y548R 548 Y R 0.742 Pathogenic MLH1 P40692 Y548S 548 Y S 0.376 Neutral MLH1 P40692 Y548T 548 Y T 0.268 Neutral MLH1 P40692 Y548V 548 Y V 0.74 Pathogenic MLH1 P40692 Y548W 548 Y W 0.79 Pathogenic MLH1 P40692 L549A 549 L A 0.634 Pathogenic MLH1 P40692 L549C 549 L C 0.76 Pathogenic MLH1 P40692 L549D 549 L D 0.884 Pathogenic MLH1 P40692 L549E 549 L E 0.864 Pathogenic MLH1 P40692 L549F 549 L F 0.788 Pathogenic MLH1 P40692 L549G 549 L G 0.796 Pathogenic MLH1 P40692 L549H 549 L H 0.876 Pathogenic MLH1 P40692 L549I 549 L I 0.22 Neutral MLH1 P40692 L549K 549 L K 0.752 Pathogenic MLH1 P40692 L549M 549 L M 0.17 Neutral MLH1 P40692 L549N 549 L N 0.748 Pathogenic MLH1 P40692 L549P 549 L P 0.99 Pathogenic MLH1 P40692 L549Q 549 L Q 0.686 Pathogenic MLH1 P40692 L549R 549 L R 0.984 Pathogenic MLH1 P40692 L549S 549 L S 0.192 Neutral MLH1 P40692 L549T 549 L T 0.328 Neutral MLH1 P40692 L549V 549 L V 0.292 Neutral MLH1 P40692 L549W 549 L W 0.942 Pathogenic MLH1 P40692 L549Y 549 L Y 0.904 Pathogenic MLH1 P40692 G55A 55 G A 0.15 Neutral MLH1 P40692 G55C 55 G C 0.354 Neutral MLH1 P40692 G55D 55 G D 0.424 Neutral MLH1 P40692 G55E 55 G E 0.42 Neutral MLH1 P40692 G55F 55 G F 0.756 Pathogenic MLH1 P40692 G55H 55 G H 0.698 Pathogenic MLH1 P40692 G55I 55 G I 0.676 Pathogenic MLH1 P40692 G55K 55 G K 0.68 Pathogenic MLH1 P40692 G55L 55 G L 0.676 Pathogenic MLH1 P40692 G55M 55 G M 0.688 Pathogenic MLH1 P40692 G55N 55 G N 0.418 Neutral MLH1 P40692 G55P 55 G P 0.636 Pathogenic MLH1 P40692 G55Q 55 G Q 0.452 Neutral MLH1 P40692 G55R 55 G R 0.744 Pathogenic MLH1 P40692 G55S 55 G S 0.29 Neutral MLH1 P40692 G55T 55 G T 0.468 Neutral MLH1 P40692 G55V 55 G V 0.658 Pathogenic MLH1 P40692 G55W 55 G W 0.754 Pathogenic MLH1 P40692 G55Y 55 G Y 0.738 Pathogenic MLH1 P40692 L550A 550 L A 0.042 Neutral MLH1 P40692 L550C 550 L C 0.024 Neutral MLH1 P40692 L550D 550 L D 0.646 Pathogenic MLH1 P40692 L550E 550 L E 0.598 Pathogenic MLH1 P40692 L550F 550 L F 0.542 Pathogenic MLH1 P40692 L550G 550 L G 0.32 Neutral MLH1 P40692 L550H 550 L H 0.386 Neutral MLH1 P40692 L550I 550 L I 0.038 Neutral MLH1 P40692 L550K 550 L K 0.474 Neutral MLH1 P40692 L550M 550 L M 0.44 Neutral MLH1 P40692 L550N 550 L N 0.596 Pathogenic MLH1 P40692 L550P 550 L P 0.952 Pathogenic 4 MLH1 P40692 L550Q 550 L Q 0.2 Neutral MLH1 P40692 L550R 550 L R 0.862 Pathogenic MLH1 P40692 L550S 550 L S 0.222 Neutral MLH1 P40692 L550T 550 L T 0.22 Neutral MLH1 P40692 L550V 550 L V 0.054 Neutral MLH1 P40692 L550W 550 L W 0.866 Pathogenic MLH1 P40692 L550Y 550 L Y 0.862 Pathogenic MLH1 P40692 N551A 551 N A 0.342 Neutral MLH1 P40692 N551C 551 N C 0.552 Pathogenic MLH1 P40692 N551D 551 N D 0.23 Neutral MLH1 P40692 N551E 551 N E 0.666 Pathogenic MLH1 P40692 N551F 551 N F 0.96 Pathogenic MLH1 P40692 N551G 551 N G 0.4 Neutral MLH1 P40692 N551H 551 N H 0.888 Pathogenic MLH1 P40692 N551I 551 N I 0.936 Pathogenic MLH1 P40692 N551K 551 N K 0.416 Neutral MLH1 P40692 N551L 551 N L 0.788 Pathogenic MLH1 P40692 N551M 551 N M 0.938 Pathogenic MLH1 P40692 N551P 551 N P 0.838 Pathogenic MLH1 P40692 N551Q 551 N Q 0.594 Pathogenic MLH1 P40692 N551R 551 N R 0.564 Pathogenic MLH1 P40692 N551S 551 N S 0.2 Neutral MLH1 P40692 N551T 551 N T 0.636 Pathogenic MLH1 P40692 N551V 551 N V 0.972 Pathogenic MLH1 P40692 N551W 551 N W 0.966 Pathogenic MLH1 P40692 N551Y 551 N Y 0.932 Pathogenic MLH1 P40692 T552A 552 T A 0.456 Neutral MLH1 P40692 T552C 552 T C 0.59 Pathogenic MLH1 P40692 T552D 552 T D 0.394 Neutral MLH1 P40692 T552E 552 T E 0.694 Pathogenic MLH1 P40692 T552F 552 T F 0.782 Pathogenic MLH1 P40692 T552G 552 T G 0.33 Neutral MLH1 P40692 T552H 552 T H 0.204 Neutral MLH1 P40692 T552I 552 T I 0.324 Neutral MLH1 P40692 T552K 552 T K 0.622 Pathogenic MLH1 P40692 T552L 552 T L 0.092 Neutral MLH1 P40692 T552M 552 T M 0.544 Pathogenic MLH1 P40692 T552N 552 T N 0.16 Neutral MLH1 P40692 T552P 552 T P 0.698 Pathogenic MLH1 P40692 T552Q 552 T Q 0.436 Neutral MLH1 P40692 T552R 552 T R 0.862 Pathogenic MLH1 P40692 T552S 552 T S 0.016 Neutral MLH1 P40692 T552V 552 T V 0.052 Neutral MLH1 P40692 T552W 552 T W 0.944 Pathogenic MLH1 P40692 T552Y 552 T Y 0.582 Pathogenic MLH1 P40692 T553A 553 T A 0.028 Neutral MLH1 P40692 T553C 553 T C 0.042 Neutral MLH1 P40692 T553D 553 T D 0.076 Neutral MLH1 P40692 T553E 553 T E 0.092 Neutral MLH1 P40692 T553F 553 T F 0.472 Neutral MLH1 P40692 T553G 553 T G 0.044 Neutral MLH1 P40692 T553H 553 T H 0.37 Neutral MLH1 P40692 T553I 553 T I 0.25 Neutral MLH1 P40692 T553K 553 T K 0.052 Neutral MLH1 P40692 T553L 553 T L 0.058 Neutral MLH1 P40692 T553M 553 T M 0.486 Neutral MLH1 P40692 T553N 553 T N 0.028 Neutral MLH1 P40692 T553P 553 T P 0.28 Neutral MLH1 P40692 T553Q 553 T Q 0.03 Neutral MLH1 P40692 T553R 553 T R 0.368 Neutral MLH1 P40692 T553S 553 T S 0.03 Neutral MLH1 P40692 T553V 553 T V 0.052 Neutral MLH1 P40692 T553W 553 T W 0.87 Pathogenic MLH1 P40692 T553Y 553 T Y 0.862 Pathogenic MLH1 P40692 K554A 554 K A 0.078 Neutral MLH1 P40692 K554C 554 K C 0.218 Neutral MLH1 P40692 K554D 554 K D 0.17 Neutral MLH1 P40692 K554E 554 K E 0.036 Neutral MLH1 P40692 K554F 554 K F 0.356 Neutral MLH1 P40692 K554G 554 K G 0.346 Neutral MLH1 P40692 K554H 554 K H 0.028 Neutral MLH1 P40692 K554I 554 K I 0.19 Neutral MLH1 P40692 K554L 554 K L 0.08 Neutral MLH1 P40692 K554M 554 K M 0.064 Neutral MLH1 P40692 K554N 554 K N 0.04 Neutral MLH1 P40692 K554P 554 K P 0.7 Pathogenic MLH1 P40692 K554Q 554 K Q 0.074 Neutral MLH1 P40692 K554R 554 K R 0.032 Neutral MLH1 P40692 K554S 554 K S 0.064 Neutral MLH1 P40692 K554T 554 K T 0.068 Neutral MLH1 P40692 K554V 554 K V 0.108 Neutral MLH1 P40692 K554W 554 K W 0.874 Pathogenic MLH1 P40692 K554Y 554 K Y 0.796 Pathogenic MLH1 P40692 L555A 555 L A 0.04 Neutral MLH1 P40692 L555C 555 L C 0.168 Neutral MLH1 P40692 L555D 555 L D 0.678 Pathogenic MLH1 P40692 L555E 555 L E 0.634 Pathogenic MLH1 P40692 L555F 555 L F 0.264 Neutral MLH1 P40692 L555G 555 L G 0.58 Pathogenic MLH1 P40692 L555H 555 L H 0.434 Neutral MLH1 P40692 L555I 555 L I 0.038 Neutral MLH1 P40692 L555K 555 L K 0.484 Neutral MLH1 P40692 L555M 555 L M 0.02 Neutral MLH1 P40692 L555N 555 L N 0.622 Pathogenic MLH1 P40692 L555P 555 L P 0.95 Pathogenic 4 MLH1 P40692 L555Q 555 L Q 0.372 Neutral MLH1 P40692 L555R 555 L R 0.87 Pathogenic MLH1 P40692 L555S 555 L S 0.394 Neutral MLH1 P40692 L555T 555 L T 0.036 Neutral MLH1 P40692 L555V 555 L V 0.002 Neutral MLH1 P40692 L555W 555 L W 0.844 Pathogenic MLH1 P40692 L555Y 555 L Y 0.836 Pathogenic MLH1 P40692 S556A 556 S A 0.042 Neutral MLH1 P40692 S556C 556 S C 0.052 Neutral MLH1 P40692 S556D 556 S D 0.5 Pathogenic MLH1 P40692 S556E 556 S E 0.738 Pathogenic MLH1 P40692 S556F 556 S F 0.682 Pathogenic MLH1 P40692 S556G 556 S G 0.234 Neutral MLH1 P40692 S556H 556 S H 0.802 Pathogenic MLH1 P40692 S556I 556 S I 0.35 Neutral MLH1 P40692 S556K 556 S K 0.738 Pathogenic MLH1 P40692 S556L 556 S L 0.148 Neutral MLH1 P40692 S556M 556 S M 0.896 Pathogenic MLH1 P40692 S556N 556 S N 0.28 Neutral MLH1 P40692 S556P 556 S P 0.494 Neutral MLH1 P40692 S556Q 556 S Q 0.692 Pathogenic MLH1 P40692 S556R 556 S R 0.466 Neutral MLH1 P40692 S556T 556 S T 0.06 Neutral MLH1 P40692 S556V 556 S V 0.118 Neutral MLH1 P40692 S556W 556 S W 0.948 Pathogenic MLH1 P40692 S556Y 556 S Y 0.928 Pathogenic MLH1 P40692 E557A 557 E A 0.188 Neutral MLH1 P40692 E557C 557 E C 0.386 Neutral MLH1 P40692 E557D 557 E D 0.086 Neutral MLH1 P40692 E557F 557 E F 0.104 Neutral MLH1 P40692 E557G 557 E G 0.302 Neutral MLH1 P40692 E557H 557 E H 0.062 Neutral MLH1 P40692 E557I 557 E I 0.836 Pathogenic MLH1 P40692 E557K 557 E K 0.028 Neutral MLH1 P40692 E557L 557 E L 0.114 Neutral MLH1 P40692 E557M 557 E M 0.664 Pathogenic MLH1 P40692 E557N 557 E N 0.014 Neutral MLH1 P40692 E557P 557 E P 0.84 Pathogenic MLH1 P40692 E557Q 557 E Q 0.012 Neutral MLH1 P40692 E557R 557 E R 0.078 Neutral MLH1 P40692 E557S 557 E S 0.04 Neutral MLH1 P40692 E557T 557 E T 0.614 Pathogenic MLH1 P40692 E557V 557 E V 0.792 Pathogenic MLH1 P40692 E557W 557 E W 0.922 Pathogenic MLH1 P40692 E557Y 557 E Y 0.316 Neutral MLH1 P40692 E558A 558 E A 0.418 Neutral MLH1 P40692 E558C 558 E C 0.334 Neutral MLH1 P40692 E558D 558 E D 0.268 Neutral MLH1 P40692 E558F 558 E F 0.97 Pathogenic MLH1 P40692 E558G 558 E G 0.376 Neutral MLH1 P40692 E558H 558 E H 0.298 Neutral MLH1 P40692 E558I 558 E I 0.806 Pathogenic MLH1 P40692 E558K 558 E K 0.982 Pathogenic MLH1 P40692 E558L 558 E L 0.98 Pathogenic MLH1 P40692 E558M 558 E M 0.706 Pathogenic MLH1 P40692 E558N 558 E N 0.252 Neutral MLH1 P40692 E558P 558 E P 0.934 Pathogenic MLH1 P40692 E558Q 558 E Q 0.144 Neutral MLH1 P40692 E558R 558 E R 0.888 Pathogenic MLH1 P40692 E558S 558 E S 0.34 Neutral MLH1 P40692 E558T 558 E T 0.878 Pathogenic MLH1 P40692 E558V 558 E V 0.666 Pathogenic MLH1 P40692 E558W 558 E W 0.986 Pathogenic MLH1 P40692 E558Y 558 E Y 0.966 Pathogenic MLH1 P40692 L559A 559 L A 0.19 Neutral MLH1 P40692 L559C 559 L C 0.27 Neutral MLH1 P40692 L559D 559 L D 0.914 Pathogenic MLH1 P40692 L559E 559 L E 0.892 Pathogenic MLH1 P40692 L559F 559 L F 0.446 Neutral MLH1 P40692 L559G 559 L G 0.81 Pathogenic MLH1 P40692 L559H 559 L H 0.176 Neutral MLH1 P40692 L559I 559 L I 0.796 Pathogenic MLH1 P40692 L559K 559 L K 0.708 Pathogenic MLH1 P40692 L559M 559 L M 0.172 Neutral MLH1 P40692 L559N 559 L N 0.478 Neutral MLH1 P40692 L559P 559 L P 0.978 Pathogenic MLH1 P40692 L559Q 559 L Q 0.612 Pathogenic MLH1 P40692 L559R 559 L R 0.998 Pathogenic 4 MLH1 P40692 L559S 559 L S 0.334 Neutral MLH1 P40692 L559T 559 L T 0.32 Neutral MLH1 P40692 L559V 559 L V 0.092 Neutral MLH1 P40692 L559W 559 L W 0.872 Pathogenic MLH1 P40692 L559Y 559 L Y 0.638 Pathogenic MLH1 P40692 L56A 56 L A 0.124 Neutral MLH1 P40692 L56C 56 L C 0.13 Neutral MLH1 P40692 L56D 56 L D 0.242 Neutral MLH1 P40692 L56E 56 L E 0.226 Neutral MLH1 P40692 L56F 56 L F 0.366 Neutral MLH1 P40692 L56G 56 L G 0.258 Neutral MLH1 P40692 L56H 56 L H 0.122 Neutral MLH1 P40692 L56I 56 L I 0.112 Neutral MLH1 P40692 L56K 56 L K 0.176 Neutral MLH1 P40692 L56M 56 L M 0.23 Neutral MLH1 P40692 L56N 56 L N 0.234 Neutral MLH1 P40692 L56P 56 L P 0.334 Neutral MLH1 P40692 L56Q 56 L Q 0.1 Neutral MLH1 P40692 L56R 56 L R 0.496 Neutral MLH1 P40692 L56S 56 L S 0.19 Neutral MLH1 P40692 L56T 56 L T 0.17 Neutral MLH1 P40692 L56V 56 L V 0.23 Neutral MLH1 P40692 L56W 56 L W 0.526 Pathogenic MLH1 P40692 L56Y 56 L Y 0.488 Neutral MLH1 P40692 F560A 560 F A 0.14 Neutral MLH1 P40692 F560C 560 F C 0.17 Neutral MLH1 P40692 F560D 560 F D 0.772 Pathogenic MLH1 P40692 F560E 560 F E 0.856 Pathogenic MLH1 P40692 F560G 560 F G 0.298 Neutral MLH1 P40692 F560H 560 F H 0.284 Neutral MLH1 P40692 F560I 560 F I 0.232 Neutral MLH1 P40692 F560K 560 F K 0.838 Pathogenic MLH1 P40692 F560L 560 F L 0.104 Neutral MLH1 P40692 F560M 560 F M 0.102 Neutral MLH1 P40692 F560N 560 F N 0.692 Pathogenic MLH1 P40692 F560P 560 F P 0.488 Neutral MLH1 P40692 F560Q 560 F Q 0.724 Pathogenic MLH1 P40692 F560R 560 F R 0.908 Pathogenic MLH1 P40692 F560S 560 F S 0.758 Pathogenic MLH1 P40692 F560T 560 F T 0.576 Pathogenic MLH1 P40692 F560V 560 F V 0.242 Neutral MLH1 P40692 F560W 560 F W 0.944 Pathogenic MLH1 P40692 F560Y 560 F Y 0.286 Neutral MLH1 P40692 Y561A 561 Y A 0.434 Neutral MLH1 P40692 Y561C 561 Y C 0.68 Pathogenic MLH1 P40692 Y561D 561 Y D 0.828 Pathogenic MLH1 P40692 Y561E 561 Y E 0.44 Neutral MLH1 P40692 Y561F 561 Y F 0.346 Neutral MLH1 P40692 Y561G 561 Y G 0.48 Neutral MLH1 P40692 Y561H 561 Y H 0.582 Pathogenic MLH1 P40692 Y561I 561 Y I 0.792 Pathogenic MLH1 P40692 Y561K 561 Y K 0.798 Pathogenic MLH1 P40692 Y561L 561 Y L 0.298 Neutral MLH1 P40692 Y561M 561 Y M 0.666 Pathogenic MLH1 P40692 Y561N 561 Y N 0.726 Pathogenic MLH1 P40692 Y561P 561 Y P 0.77 Pathogenic MLH1 P40692 Y561Q 561 Y Q 0.636 Pathogenic MLH1 P40692 Y561R 561 Y R 0.474 Neutral MLH1 P40692 Y561S 561 Y S 0.282 Neutral MLH1 P40692 Y561T 561 Y T 0.676 Pathogenic MLH1 P40692 Y561V 561 Y V 0.618 Pathogenic MLH1 P40692 Y561W 561 Y W 0.9 Pathogenic MLH1 P40692 Q562A 562 Q A 0.786 Pathogenic MLH1 P40692 Q562C 562 Q C 0.76 Pathogenic MLH1 P40692 Q562D 562 Q D 0.862 Pathogenic MLH1 P40692 Q562E 562 Q E 0.21 Neutral MLH1 P40692 Q562F 562 Q F 0.924 Pathogenic MLH1 P40692 Q562G 562 Q G 0.57 Pathogenic MLH1 P40692 Q562H 562 Q H 0.946 Pathogenic MLH1 P40692 Q562I 562 Q I 0.95 Pathogenic MLH1 P40692 Q562K 562 Q K 0.49 Neutral MLH1 P40692 Q562L 562 Q L 0.866 Pathogenic MLH1 P40692 Q562M 562 Q M 0.902 Pathogenic MLH1 P40692 Q562N 562 Q N 0.9 Pathogenic MLH1 P40692 Q562P 562 Q P 0.91 Pathogenic MLH1 P40692 Q562R 562 Q R 0.502 Pathogenic MLH1 P40692 Q562S 562 Q S 0.736 Pathogenic MLH1 P40692 Q562T 562 Q T 0.534 Pathogenic MLH1 P40692 Q562V 562 Q V 0.916 Pathogenic MLH1 P40692 Q562W 562 Q W 0.95 Pathogenic MLH1 P40692 Q562Y 562 Q Y 0.942 Pathogenic MLH1 P40692 I563A 563 I A 0.26 Neutral MLH1 P40692 I563C 563 I C 0.408 Neutral MLH1 P40692 I563D 563 I D 0.61 Pathogenic MLH1 P40692 I563E 563 I E 0.592 Pathogenic MLH1 P40692 I563F 563 I F 0.576 Pathogenic MLH1 P40692 I563G 563 I G 0.586 Pathogenic MLH1 P40692 I563H 563 I H 0.132 Neutral MLH1 P40692 I563K 563 I K 0.242 Neutral MLH1 P40692 I563L 563 I L 0.01 Neutral MLH1 P40692 I563M 563 I M 0.396 Neutral MLH1 P40692 I563N 563 I N 0.618 Pathogenic MLH1 P40692 I563P 563 I P 0.754 Pathogenic MLH1 P40692 I563Q 563 I Q 0.148 Neutral MLH1 P40692 I563R 563 I R 0.552 Pathogenic MLH1 P40692 I563S 563 I S 0.11 Neutral MLH1 P40692 I563T 563 I T 0.034 Neutral MLH1 P40692 I563V 563 I V 0.008 Neutral MLH1 P40692 I563W 563 I W 0.904 Pathogenic MLH1 P40692 I563Y 563 I Y 0.904 Pathogenic MLH1 P40692 L564A 564 L A 0.06 Neutral MLH1 P40692 L564C 564 L C 0.048 Neutral MLH1 P40692 L564D 564 L D 0.604 Pathogenic MLH1 P40692 L564E 564 L E 0.56 Pathogenic MLH1 P40692 L564F 564 L F 0.56 Pathogenic MLH1 P40692 L564G 564 L G 0.126 Neutral MLH1 P40692 L564H 564 L H 0.352 Neutral MLH1 P40692 L564I 564 L I 0.078 Neutral MLH1 P40692 L564K 564 L K 0.438 Neutral MLH1 P40692 L564M 564 L M 0.028 Neutral MLH1 P40692 L564N 564 L N 0.564 Pathogenic MLH1 P40692 L564P 564 L P 0.9 Pathogenic MLH1 P40692 L564Q 564 L Q 0.22 Neutral MLH1 P40692 L564R 564 L R 0.86 Pathogenic MLH1 P40692 L564S 564 L S 0.058 Neutral MLH1 P40692 L564T 564 L T 0.248 Neutral MLH1 P40692 L564V 564 L V 0.012 Neutral MLH1 P40692 L564W 564 L W 0.84 Pathogenic MLH1 P40692 L564Y 564 L Y 0.866 Pathogenic MLH1 P40692 I565A 565 I A 0.156 Neutral MLH1 P40692 I565C 565 I C 0.626 Pathogenic MLH1 P40692 I565D 565 I D 0.778 Pathogenic MLH1 P40692 I565E 565 I E 0.782 Pathogenic MLH1 P40692 I565F 565 I F 0.936 Pathogenic MLH1 P40692 I565G 565 I G 0.816 Pathogenic MLH1 P40692 I565H 565 I H 0.844 Pathogenic MLH1 P40692 I565K 565 I K 0.856 Pathogenic MLH1 P40692 I565L 565 I L 0.236 Neutral MLH1 P40692 I565M 565 I M 0.216 Neutral MLH1 P40692 I565N 565 I N 0.8 Pathogenic MLH1 P40692 I565P 565 I P 0.924 Pathogenic MLH1 P40692 I565Q 565 I Q 0.808 Pathogenic MLH1 P40692 I565R 565 I R 0.554 Pathogenic MLH1 P40692 I565S 565 I S 0.614 Pathogenic MLH1 P40692 I565T 565 I T 0.37 Neutral MLH1 P40692 I565V 565 I V 0.116 Neutral MLH1 P40692 I565W 565 I W 0.958 Pathogenic MLH1 P40692 I565Y 565 I Y 0.952 Pathogenic MLH1 P40692 Y566A 566 Y A 0.24 Neutral MLH1 P40692 Y566C 566 Y C 0.132 Neutral MLH1 P40692 Y566D 566 Y D 0.356 Neutral MLH1 P40692 Y566E 566 Y E 0.106 Neutral MLH1 P40692 Y566F 566 Y F 0.026 Neutral MLH1 P40692 Y566G 566 Y G 0.358 Neutral MLH1 P40692 Y566H 566 Y H 0.034 Neutral MLH1 P40692 Y566I 566 Y I 0.394 Neutral MLH1 P40692 Y566K 566 Y K 0.066 Neutral MLH1 P40692 Y566L 566 Y L 0.052 Neutral MLH1 P40692 Y566M 566 Y M 0.346 Neutral MLH1 P40692 Y566N 566 Y N 0.13 Neutral MLH1 P40692 Y566P 566 Y P 0.33 Neutral MLH1 P40692 Y566Q 566 Y Q 0.112 Neutral MLH1 P40692 Y566R 566 Y R 0.086 Neutral MLH1 P40692 Y566S 566 Y S 0.166 Neutral MLH1 P40692 Y566T 566 Y T 0.128 Neutral MLH1 P40692 Y566V 566 Y V 0.448 Neutral MLH1 P40692 Y566W 566 Y W 0.36 Neutral MLH1 P40692 D567A 567 D A 0.532 Pathogenic MLH1 P40692 D567C 567 D C 0.734 Pathogenic MLH1 P40692 D567E 567 D E 0.03 Neutral MLH1 P40692 D567F 567 D F 0.946 Pathogenic MLH1 P40692 D567G 567 D G 0.08 Neutral MLH1 P40692 D567H 567 D H 0.496 Neutral MLH1 P40692 D567I 567 D I 0.914 Pathogenic MLH1 P40692 D567K 567 D K 0.748 Pathogenic MLH1 P40692 D567L 567 D L 0.908 Pathogenic MLH1 P40692 D567M 567 D M 0.822 Pathogenic MLH1 P40692 D567N 567 D N 0.012 Neutral MLH1 P40692 D567P 567 D P 0.804 Pathogenic MLH1 P40692 D567Q 567 D Q 0.014 Neutral MLH1 P40692 D567R 567 D R 0.48 Neutral MLH1 P40692 D567S 567 D S 0.042 Neutral MLH1 P40692 D567T 567 D T 0.58 Pathogenic MLH1 P40692 D567V 567 D V 0.936 Pathogenic MLH1 P40692 D567W 567 D W 0.964 Pathogenic MLH1 P40692 D567Y 567 D Y 0.956 Pathogenic MLH1 P40692 F568A 568 F A 0.496 Neutral MLH1 P40692 F568C 568 F C 0.714 Pathogenic MLH1 P40692 F568D 568 F D 0.444 Neutral MLH1 P40692 F568E 568 F E 0.836 Pathogenic MLH1 P40692 F568G 568 F G 0.5 Pathogenic MLH1 P40692 F568H 568 F H 0.748 Pathogenic MLH1 P40692 F568I 568 F I 0.312 Neutral MLH1 P40692 F568K 568 F K 0.816 Pathogenic MLH1 P40692 F568L 568 F L 0.254 Neutral MLH1 P40692 F568M 568 F M 0.768 Pathogenic MLH1 P40692 F568N 568 F N 0.736 Pathogenic MLH1 P40692 F568P 568 F P 0.944 Pathogenic MLH1 P40692 F568Q 568 F Q 0.748 Pathogenic MLH1 P40692 F568R 568 F R 0.884 Pathogenic MLH1 P40692 F568S 568 F S 0.848 Pathogenic MLH1 P40692 F568T 568 F T 0.544 Pathogenic MLH1 P40692 F568V 568 F V 0.322 Neutral MLH1 P40692 F568W 568 F W 0.832 Pathogenic MLH1 P40692 F568Y 568 F Y 0.504 Pathogenic MLH1 P40692 A569C 569 A C 0.176 Neutral MLH1 P40692 A569D 569 A D 0.842 Pathogenic MLH1 P40692 A569E 569 A E 0.674 Pathogenic MLH1 P40692 A569F 569 A F 0.96 Pathogenic MLH1 P40692 A569G 569 A G 0.146 Neutral MLH1 P40692 A569H 569 A H 0.794 Pathogenic MLH1 P40692 A569I 569 A I 0.926 Pathogenic MLH1 P40692 A569K 569 A K 0.9 Pathogenic MLH1 P40692 A569L 569 A L 0.944 Pathogenic MLH1 P40692 A569M 569 A M 0.814 Pathogenic MLH1 P40692 A569N 569 A N 0.724 Pathogenic MLH1 P40692 A569P 569 A P 0.462 Neutral MLH1 P40692 A569Q 569 A Q 0.508 Pathogenic MLH1 P40692 A569R 569 A R 0.87 Pathogenic MLH1 P40692 A569S 569 A S 0.01 Neutral MLH1 P40692 A569T 569 A T 0.636 Pathogenic MLH1 P40692 A569V 569 A V 0.752 Pathogenic MLH1 P40692 A569W 569 A W 0.95 Pathogenic MLH1 P40692 A569Y 569 A Y 0.918 Pathogenic MLH1 P40692 K57A 57 K A 0.188 Neutral MLH1 P40692 K57C 57 K C 0.49 Neutral MLH1 P40692 K57D 57 K D 0.282 Neutral MLH1 P40692 K57E 57 K E 0.798 Pathogenic MLH1 P40692 K57F 57 K F 0.972 Pathogenic MLH1 P40692 K57G 57 K G 0.214 Neutral MLH1 P40692 K57H 57 K H 0.808 Pathogenic MLH1 P40692 K57I 57 K I 0.988 Pathogenic MLH1 P40692 K57L 57 K L 0.706 Pathogenic MLH1 P40692 K57M 57 K M 0.928 Pathogenic MLH1 P40692 K57N 57 K N 0.308 Neutral MLH1 P40692 K57P 57 K P 0.924 Pathogenic MLH1 P40692 K57Q 57 K Q 0.804 Pathogenic MLH1 P40692 K57R 57 K R 0.186 Neutral MLH1 P40692 K57S 57 K S 0.72 Pathogenic MLH1 P40692 K57T 57 K T 0.65 Pathogenic MLH1 P40692 K57V 57 K V 0.886 Pathogenic MLH1 P40692 K57W 57 K W 0.992 Pathogenic MLH1 P40692 K57Y 57 K Y 0.984 Pathogenic MLH1 P40692 N570A 570 N A 0.256 Neutral MLH1 P40692 N570C 570 N C 0.756 Pathogenic MLH1 P40692 N570D 570 N D 0.22 Neutral MLH1 P40692 N570E 570 N E 0.414 Neutral MLH1 P40692 N570F 570 N F 0.966 Pathogenic MLH1 P40692 N570G 570 N G 0.406 Neutral MLH1 P40692 N570H 570 N H 0.404 Neutral MLH1 P40692 N570I 570 N I 0.948 Pathogenic MLH1 P40692 N570K 570 N K 0.97 Pathogenic MLH1 P40692 N570L 570 N L 0.964 Pathogenic MLH1 P40692 N570M 570 N M 0.956 Pathogenic MLH1 P40692 N570P 570 N P 0.76 Pathogenic MLH1 P40692 N570Q 570 N Q 0.298 Neutral MLH1 P40692 N570R 570 N R 0.56 Pathogenic MLH1 P40692 N570S 570 N S 0.198 Neutral MLH1 P40692 N570T 570 N T 0.67 Pathogenic MLH1 P40692 N570V 570 N V 0.984 Pathogenic MLH1 P40692 N570W 570 N W 0.976 Pathogenic MLH1 P40692 N570Y 570 N Y 0.97 Pathogenic MLH1 P40692 F571A 571 F A 0.406 Neutral MLH1 P40692 F571C 571 F C 0.126 Neutral MLH1 P40692 F571D 571 F D 0.818 Pathogenic MLH1 P40692 F571E 571 F E 0.92 Pathogenic MLH1 P40692 F571G 571 F G 0.5 Pathogenic MLH1 P40692 F571H 571 F H 0.16 Neutral MLH1 P40692 F571I 571 F I 0.51 Pathogenic MLH1 P40692 F571K 571 F K 0.88 Pathogenic MLH1 P40692 F571L 571 F L 0.098 Neutral MLH1 P40692 F571M 571 F M 0.108 Neutral MLH1 P40692 F571N 571 F N 0.75 Pathogenic MLH1 P40692 F571P 571 F P 0.866 Pathogenic MLH1 P40692 F571Q 571 F Q 0.788 Pathogenic MLH1 P40692 F571R 571 F R 0.924 Pathogenic MLH1 P40692 F571S 571 F S 0.25 Neutral MLH1 P40692 F571T 571 F T 0.228 Neutral MLH1 P40692 F571V 571 F V 0.242 Neutral MLH1 P40692 F571W 571 F W 0.814 Pathogenic MLH1 P40692 F571Y 571 F Y 0.206 Neutral MLH1 P40692 G572A 572 G A 0.072 Neutral MLH1 P40692 G572C 572 G C 0.81 Pathogenic MLH1 P40692 G572D 572 G D 0.478 Neutral MLH1 P40692 G572E 572 G E 0.554 Pathogenic MLH1 P40692 G572F 572 G F 0.972 Pathogenic MLH1 P40692 G572H 572 G H 0.752 Pathogenic MLH1 P40692 G572I 572 G I 0.958 Pathogenic MLH1 P40692 G572K 572 G K 0.61 Pathogenic MLH1 P40692 G572L 572 G L 0.928 Pathogenic MLH1 P40692 G572M 572 G M 0.984 Pathogenic MLH1 P40692 G572N 572 G N 0.484 Neutral MLH1 P40692 G572P 572 G P 0.638 Pathogenic MLH1 P40692 G572Q 572 G Q 0.726 Pathogenic MLH1 P40692 G572R 572 G R 0.646 Pathogenic MLH1 P40692 G572S 572 G S 0.09 Neutral MLH1 P40692 G572T 572 G T 0.846 Pathogenic MLH1 P40692 G572V 572 G V 0.974 Pathogenic MLH1 P40692 G572W 572 G W 0.956 Pathogenic MLH1 P40692 G572Y 572 G Y 0.914 Pathogenic MLH1 P40692 V573A 573 V A 0 Neutral MLH1 P40692 V573C 573 V C 0.044 Neutral MLH1 P40692 V573D 573 V D 0.186 Neutral MLH1 P40692 V573E 573 V E 0.068 Neutral MLH1 P40692 V573F 573 V F 0.238 Neutral MLH1 P40692 V573G 573 V G 0.27 Neutral MLH1 P40692 V573H 573 V H 0.172 Neutral MLH1 P40692 V573I 573 V I 0.006 Neutral MLH1 P40692 V573K 573 V K 0.082 Neutral MLH1 P40692 V573L 573 V L 0 Neutral MLH1 P40692 V573M 573 V M 0.118 Neutral MLH1 P40692 V573N 573 V N 0.206 Neutral MLH1 P40692 V573P 573 V P 0.06 Neutral MLH1 P40692 V573Q 573 V Q 0.144 Neutral MLH1 P40692 V573R 573 V R 0.316 Neutral MLH1 P40692 V573S 573 V S 0.016 Neutral MLH1 P40692 V573T 573 V T 0.008 Neutral MLH1 P40692 V573W 573 V W 0.55 Pathogenic MLH1 P40692 V573Y 573 V Y 0.278 Neutral MLH1 P40692 L574A 574 L A 0.2 Neutral MLH1 P40692 L574C 574 L C 0.06 Neutral MLH1 P40692 L574D 574 L D 0.57 Pathogenic MLH1 P40692 L574E 574 L E 0.53 Pathogenic MLH1 P40692 L574F 574 L F 0.298 Neutral MLH1 P40692 L574G 574 L G 0.524 Pathogenic MLH1 P40692 L574H 574 L H 0.174 Neutral MLH1 P40692 L574I 574 L I 0.074 Neutral MLH1 P40692 L574K 574 L K 0.426 Neutral MLH1 P40692 L574M 574 L M 0.034 Neutral MLH1 P40692 L574N 574 L N 0.546 Pathogenic MLH1 P40692 L574P 574 L P 0.716 Pathogenic 4 MLH1 P40692 L574Q 574 L Q 0.28 Neutral MLH1 P40692 L574R 574 L R 0.762 Pathogenic MLH1 P40692 L574S 574 L S 0.502 Pathogenic MLH1 P40692 L574T 574 L T 0.364 Neutral MLH1 P40692 L574V 574 L V 0.032 Neutral MLH1 P40692 L574W 574 L W 0.838 Pathogenic MLH1 P40692 L574Y 574 L Y 0.614 Pathogenic MLH1 P40692 R575A 575 R A 0.384 Neutral MLH1 P40692 R575C 575 R C 0.62 Pathogenic MLH1 P40692 R575D 575 R D 0.598 Pathogenic MLH1 P40692 R575E 575 R E 0.052 Neutral MLH1 P40692 R575F 575 R F 0.85 Pathogenic MLH1 P40692 R575G 575 R G 0.158 Neutral MLH1 P40692 R575H 575 R H 0.282 Neutral MLH1 P40692 R575I 575 R I 0.2 Neutral MLH1 P40692 R575K 575 R K 0.026 Neutral MLH1 P40692 R575L 575 R L 0.206 Neutral MLH1 P40692 R575M 575 R M 0.624 Pathogenic MLH1 P40692 R575N 575 R N 0.026 Neutral MLH1 P40692 R575P 575 R P 0.732 Pathogenic MLH1 P40692 R575Q 575 R Q 0.02 Neutral MLH1 P40692 R575S 575 R S 0.434 Neutral MLH1 P40692 R575T 575 R T 0.04 Neutral MLH1 P40692 R575V 575 R V 0.78 Pathogenic MLH1 P40692 R575W 575 R W 0.854 Pathogenic MLH1 P40692 R575Y 575 R Y 0.132 Neutral MLH1 P40692 L576A 576 L A 0.3 Neutral MLH1 P40692 L576C 576 L C 0.116 Neutral MLH1 P40692 L576D 576 L D 0.656 Pathogenic MLH1 P40692 L576E 576 L E 0.61 Pathogenic MLH1 P40692 L576F 576 L F 0.262 Neutral MLH1 P40692 L576G 576 L G 0.456 Neutral MLH1 P40692 L576H 576 L H 0.406 Neutral MLH1 P40692 L576I 576 L I 0.342 Neutral MLH1 P40692 L576K 576 L K 0.422 Neutral MLH1 P40692 L576M 576 L M 0.41 Neutral MLH1 P40692 L576N 576 L N 0.484 Neutral MLH1 P40692 L576P 576 L P 0.954 Pathogenic MLH1 P40692 L576Q 576 L Q 0.35 Neutral MLH1 P40692 L576R 576 L R 0.578 Pathogenic MLH1 P40692 L576S 576 L S 0.402 Neutral MLH1 P40692 L576T 576 L T 0.382 Neutral MLH1 P40692 L576V 576 L V 0.4 Neutral MLH1 P40692 L576W 576 L W 0.864 Pathogenic MLH1 P40692 L576Y 576 L Y 0.854 Pathogenic MLH1 P40692 S577A 577 S A 0.052 Neutral MLH1 P40692 S577C 577 S C 0.148 Neutral MLH1 P40692 S577D 577 S D 0.01 Neutral MLH1 P40692 S577E 577 S E 0.298 Neutral MLH1 P40692 S577F 577 S F 0.426 Neutral MLH1 P40692 S577G 577 S G 0.168 Neutral MLH1 P40692 S577H 577 S H 0.404 Neutral MLH1 P40692 S577I 577 S I 0.272 Neutral MLH1 P40692 S577K 577 S K 0.434 Neutral MLH1 P40692 S577L 577 S L 0.178 Neutral MLH1 P40692 S577M 577 S M 0.742 Pathogenic MLH1 P40692 S577N 577 S N 0.01 Neutral MLH1 P40692 S577P 577 S P 0.292 Neutral MLH1 P40692 S577Q 577 S Q 0.34 Neutral MLH1 P40692 S577R 577 S R 0.554 Pathogenic MLH1 P40692 S577T 577 S T 0.024 Neutral MLH1 P40692 S577V 577 S V 0.542 Pathogenic MLH1 P40692 S577W 577 S W 0.856 Pathogenic MLH1 P40692 S577Y 577 S Y 0.82 Pathogenic MLH1 P40692 E578A 578 E A 0.196 Neutral MLH1 P40692 E578C 578 E C 0.128 Neutral MLH1 P40692 E578D 578 E D 0.142 Neutral MLH1 P40692 E578F 578 E F 0.438 Neutral MLH1 P40692 E578G 578 E G 0.034 Neutral 1 MLH1 P40692 E578H 578 E H 0.292 Neutral MLH1 P40692 E578I 578 E I 0.478 Neutral MLH1 P40692 E578K 578 E K 0.296 Neutral MLH1 P40692 E578L 578 E L 0.468 Neutral MLH1 P40692 E578M 578 E M 0.298 Neutral MLH1 P40692 E578N 578 E N 0.002 Neutral MLH1 P40692 E578P 578 E P 0.072 Neutral MLH1 P40692 E578Q 578 E Q 0.094 Neutral MLH1 P40692 E578R 578 E R 0.124 Neutral MLH1 P40692 E578S 578 E S 0.018 Neutral MLH1 P40692 E578T 578 E T 0.012 Neutral MLH1 P40692 E578V 578 E V 0.234 Neutral MLH1 P40692 E578W 578 E W 0.74 Pathogenic MLH1 P40692 E578Y 578 E Y 0.604 Pathogenic MLH1 P40692 P579A 579 P A 0.072 Neutral MLH1 P40692 P579C 579 P C 0.466 Neutral MLH1 P40692 P579D 579 P D 0.07 Neutral MLH1 P40692 P579E 579 P E 0.156 Neutral MLH1 P40692 P579F 579 P F 0.97 Pathogenic MLH1 P40692 P579G 579 P G 0.316 Neutral MLH1 P40692 P579H 579 P H 0.868 Pathogenic MLH1 P40692 P579I 579 P I 0.788 Pathogenic MLH1 P40692 P579K 579 P K 0.716 Pathogenic MLH1 P40692 P579L 579 P L 0.776 Pathogenic MLH1 P40692 P579M 579 P M 0.754 Pathogenic MLH1 P40692 P579N 579 P N 0.374 Neutral MLH1 P40692 P579Q 579 P Q 0.52 Pathogenic MLH1 P40692 P579R 579 P R 0.54 Pathogenic MLH1 P40692 P579S 579 P S 0.02 Neutral MLH1 P40692 P579T 579 P T 0.176 Neutral MLH1 P40692 P579V 579 P V 0.516 Pathogenic MLH1 P40692 P579W 579 P W 0.908 Pathogenic MLH1 P40692 P579Y 579 P Y 0.886 Pathogenic MLH1 P40692 L58A 58 L A 0.564 Pathogenic MLH1 P40692 L58C 58 L C 0.27 Neutral MLH1 P40692 L58D 58 L D 0.526 Pathogenic MLH1 P40692 L58E 58 L E 0.89 Pathogenic MLH1 P40692 L58F 58 L F 0.478 Neutral MLH1 P40692 L58G 58 L G 0.47 Neutral MLH1 P40692 L58H 58 L H 0.334 Neutral MLH1 P40692 L58I 58 L I 0.272 Neutral MLH1 P40692 L58K 58 L K 0.722 Pathogenic MLH1 P40692 L58M 58 L M 0.164 Neutral MLH1 P40692 L58N 58 L N 0.782 Pathogenic MLH1 P40692 L58P 58 L P 0.674 Pathogenic MLH1 P40692 L58Q 58 L Q 0.612 Pathogenic MLH1 P40692 L58R 58 L R 0.996 Pathogenic MLH1 P40692 L58S 58 L S 0.142 Neutral MLH1 P40692 L58T 58 L T 0.328 Neutral MLH1 P40692 L58V 58 L V 0.094 Neutral MLH1 P40692 L58W 58 L W 0.908 Pathogenic MLH1 P40692 L58Y 58 L Y 0.818 Pathogenic MLH1 P40692 A580C 580 A C 0.674 Pathogenic MLH1 P40692 A580D 580 A D 0.862 Pathogenic MLH1 P40692 A580E 580 A E 0.884 Pathogenic MLH1 P40692 A580F 580 A F 0.91 Pathogenic MLH1 P40692 A580G 580 A G 0.514 Pathogenic MLH1 P40692 A580H 580 A H 0.87 Pathogenic MLH1 P40692 A580I 580 A I 0.62 Pathogenic MLH1 P40692 A580K 580 A K 0.914 Pathogenic MLH1 P40692 A580L 580 A L 0.574 Pathogenic MLH1 P40692 A580M 580 A M 0.546 Pathogenic MLH1 P40692 A580N 580 A N 0.772 Pathogenic MLH1 P40692 A580P 580 A P 0.138 Neutral MLH1 P40692 A580Q 580 A Q 0.734 Pathogenic MLH1 P40692 A580R 580 A R 0.928 Pathogenic MLH1 P40692 A580S 580 A S 0.426 Neutral MLH1 P40692 A580T 580 A T 0.642 Pathogenic MLH1 P40692 A580V 580 A V 0.248 Neutral MLH1 P40692 A580W 580 A W 0.956 Pathogenic MLH1 P40692 A580Y 580 A Y 0.942 Pathogenic MLH1 P40692 P581A 581 P A 0.074 Neutral MLH1 P40692 P581C 581 P C 0.586 Pathogenic MLH1 P40692 P581D 581 P D 0.04 Neutral MLH1 P40692 P581E 581 P E 0.182 Neutral MLH1 P40692 P581F 581 P F 0.902 Pathogenic MLH1 P40692 P581G 581 P G 0.264 Neutral MLH1 P40692 P581H 581 P H 0.852 Pathogenic MLH1 P40692 P581I 581 P I 0.396 Neutral MLH1 P40692 P581K 581 P K 0.128 Neutral MLH1 P40692 P581L 581 P L 0.36 Neutral 2 MLH1 P40692 P581M 581 P M 0.604 Pathogenic MLH1 P40692 P581N 581 P N 0.036 Neutral MLH1 P40692 P581Q 581 P Q 0.144 Neutral MLH1 P40692 P581R 581 P R 0.596 Pathogenic MLH1 P40692 P581S 581 P S 0.024 Neutral MLH1 P40692 P581T 581 P T 0.454 Neutral MLH1 P40692 P581V 581 P V 0.088 Neutral MLH1 P40692 P581W 581 P W 0.924 Pathogenic MLH1 P40692 P581Y 581 P Y 0.738 Pathogenic MLH1 P40692 L582A 582 L A 0.558 Pathogenic MLH1 P40692 L582C 582 L C 0.676 Pathogenic MLH1 P40692 L582D 582 L D 0.896 Pathogenic MLH1 P40692 L582E 582 L E 0.876 Pathogenic MLH1 P40692 L582F 582 L F 0.648 Pathogenic MLH1 P40692 L582G 582 L G 0.8 Pathogenic MLH1 P40692 L582H 582 L H 0.794 Pathogenic MLH1 P40692 L582I 582 L I 0.122 Neutral MLH1 P40692 L582K 582 L K 0.744 Pathogenic MLH1 P40692 L582M 582 L M 0.458 Neutral MLH1 P40692 L582N 582 L N 0.764 Pathogenic MLH1 P40692 L582P 582 L P 0.998 Pathogenic 5 MLH1 P40692 L582Q 582 L Q 0.608 Pathogenic MLH1 P40692 L582R 582 L R 0.99 Pathogenic MLH1 P40692 L582S 582 L S 0.608 Pathogenic MLH1 P40692 L582T 582 L T 0.584 Pathogenic MLH1 P40692 L582V 582 L V 0.072 Neutral MLH1 P40692 L582W 582 L W 0.94 Pathogenic MLH1 P40692 L582Y 582 L Y 0.682 Pathogenic MLH1 P40692 F583A 583 F A 0.188 Neutral MLH1 P40692 F583C 583 F C 0.044 Neutral MLH1 P40692 F583D 583 F D 0.042 Neutral MLH1 P40692 F583E 583 F E 0.062 Neutral MLH1 P40692 F583G 583 F G 0.188 Neutral MLH1 P40692 F583H 583 F H 0.008 Neutral MLH1 P40692 F583I 583 F I 0.014 Neutral MLH1 P40692 F583K 583 F K 0.058 Neutral MLH1 P40692 F583L 583 F L 0.138 Neutral MLH1 P40692 F583M 583 F M 0.17 Neutral MLH1 P40692 F583N 583 F N 0.056 Neutral MLH1 P40692 F583P 583 F P 0.106 Neutral MLH1 P40692 F583Q 583 F Q 0.058 Neutral MLH1 P40692 F583R 583 F R 0.052 Neutral MLH1 P40692 F583S 583 F S 0.162 Neutral MLH1 P40692 F583T 583 F T 0.17 Neutral MLH1 P40692 F583V 583 F V 0.022 Neutral MLH1 P40692 F583W 583 F W 0.59 Pathogenic MLH1 P40692 F583Y 583 F Y 0.026 Neutral MLH1 P40692 D584A 584 D A 0.134 Neutral MLH1 P40692 D584C 584 D C 0.678 Pathogenic MLH1 P40692 D584E 584 D E 0.036 Neutral MLH1 P40692 D584F 584 D F 0.928 Pathogenic MLH1 P40692 D584G 584 D G 0.478 Neutral MLH1 P40692 D584H 584 D H 0.33 Neutral MLH1 P40692 D584I 584 D I 0.838 Pathogenic MLH1 P40692 D584K 584 D K 0.084 Neutral MLH1 P40692 D584L 584 D L 0.434 Neutral MLH1 P40692 D584M 584 D M 0.804 Pathogenic MLH1 P40692 D584N 584 D N 0.018 Neutral MLH1 P40692 D584P 584 D P 0.806 Pathogenic MLH1 P40692 D584Q 584 D Q 0.024 Neutral MLH1 P40692 D584R 584 D R 0.49 Neutral MLH1 P40692 D584S 584 D S 0.028 Neutral MLH1 P40692 D584T 584 D T 0.054 Neutral MLH1 P40692 D584V 584 D V 0.916 Pathogenic MLH1 P40692 D584W 584 D W 0.97 Pathogenic MLH1 P40692 D584Y 584 D Y 0.964 Pathogenic MLH1 P40692 L585A 585 L A 0.566 Pathogenic MLH1 P40692 L585C 585 L C 0.298 Neutral MLH1 P40692 L585D 585 L D 0.886 Pathogenic MLH1 P40692 L585E 585 L E 0.2 Neutral MLH1 P40692 L585F 585 L F 0.794 Pathogenic MLH1 P40692 L585G 585 L G 0.468 Neutral MLH1 P40692 L585H 585 L H 0.822 Pathogenic MLH1 P40692 L585I 585 L I 0.21 Neutral MLH1 P40692 L585K 585 L K 0.742 Pathogenic MLH1 P40692 L585M 585 L M 0.468 Neutral MLH1 P40692 L585N 585 L N 0.752 Pathogenic MLH1 P40692 L585P 585 L P 0.696 Pathogenic MLH1 P40692 L585Q 585 L Q 0.202 Neutral MLH1 P40692 L585R 585 L R 0.57 Pathogenic MLH1 P40692 L585S 585 L S 0.192 Neutral MLH1 P40692 L585T 585 L T 0.334 Neutral MLH1 P40692 L585V 585 L V 0.152 Neutral MLH1 P40692 L585W 585 L W 0.94 Pathogenic MLH1 P40692 L585Y 585 L Y 0.906 Pathogenic MLH1 P40692 A586C 586 A C 0.682 Pathogenic MLH1 P40692 A586D 586 A D 0.786 Pathogenic MLH1 P40692 A586E 586 A E 0.714 Pathogenic MLH1 P40692 A586F 586 A F 0.746 Pathogenic MLH1 P40692 A586G 586 A G 0.488 Neutral MLH1 P40692 A586H 586 A H 0.872 Pathogenic MLH1 P40692 A586I 586 A I 0.62 Pathogenic MLH1 P40692 A586K 586 A K 0.714 Pathogenic MLH1 P40692 A586L 586 A L 0.578 Pathogenic MLH1 P40692 A586M 586 A M 0.702 Pathogenic MLH1 P40692 A586N 586 A N 0.604 Pathogenic MLH1 P40692 A586P 586 A P 0.884 Pathogenic MLH1 P40692 A586Q 586 A Q 0.796 Pathogenic MLH1 P40692 A586R 586 A R 0.928 Pathogenic MLH1 P40692 A586S 586 A S 0.02 Neutral MLH1 P40692 A586T 586 A T 0.06 Neutral MLH1 P40692 A586V 586 A V 0.128 Neutral MLH1 P40692 A586W 586 A W 0.954 Pathogenic MLH1 P40692 A586Y 586 A Y 0.94 Pathogenic MLH1 P40692 M587A 587 M A 0.166 Neutral MLH1 P40692 M587C 587 M C 0.228 Neutral MLH1 P40692 M587D 587 M D 0.196 Neutral MLH1 P40692 M587E 587 M E 0.046 Neutral MLH1 P40692 M587F 587 M F 0.68 Pathogenic MLH1 P40692 M587G 587 M G 0.434 Neutral MLH1 P40692 M587H 587 M H 0.048 Neutral MLH1 P40692 M587I 587 M I 0.05 Neutral MLH1 P40692 M587K 587 M K 0.066 Neutral MLH1 P40692 M587L 587 M L 0.032 Neutral MLH1 P40692 M587N 587 M N 0.384 Neutral MLH1 P40692 M587P 587 M P 0.81 Pathogenic MLH1 P40692 M587Q 587 M Q 0.038 Neutral MLH1 P40692 M587R 587 M R 0.1 Neutral MLH1 P40692 M587S 587 M S 0.058 Neutral MLH1 P40692 M587T 587 M T 0.05 Neutral MLH1 P40692 M587V 587 M V 0.072 Neutral MLH1 P40692 M587W 587 M W 0.896 Pathogenic MLH1 P40692 M587Y 587 M Y 0.836 Pathogenic MLH1 P40692 L588A 588 L A 0.072 Neutral MLH1 P40692 L588C 588 L C 0.336 Neutral MLH1 P40692 L588D 588 L D 0.122 Neutral MLH1 P40692 L588E 588 L E 0.082 Neutral MLH1 P40692 L588F 588 L F 0.778 Pathogenic MLH1 P40692 L588G 588 L G 0.36 Neutral MLH1 P40692 L588H 588 L H 0.188 Neutral MLH1 P40692 L588I 588 L I 0.06 Neutral MLH1 P40692 L588K 588 L K 0.438 Neutral MLH1 P40692 L588M 588 L M 0.032 Neutral MLH1 P40692 L588N 588 L N 0.104 Neutral MLH1 P40692 L588P 588 L P 0.844 Pathogenic MLH1 P40692 L588Q 588 L Q 0.226 Neutral MLH1 P40692 L588R 588 L R 0.86 Pathogenic MLH1 P40692 L588S 588 L S 0.258 Neutral MLH1 P40692 L588T 588 L T 0.456 Neutral MLH1 P40692 L588V 588 L V 0.022 Neutral MLH1 P40692 L588W 588 L W 0.868 Pathogenic MLH1 P40692 L588Y 588 L Y 0.866 Pathogenic MLH1 P40692 A589C 589 A C 0.748 Pathogenic MLH1 P40692 A589D 589 A D 0.778 Pathogenic 4 MLH1 P40692 A589E 589 A E 0.88 Pathogenic MLH1 P40692 A589F 589 A F 0.972 Pathogenic MLH1 P40692 A589G 589 A G 0.05 Neutral MLH1 P40692 A589H 589 A H 0.872 Pathogenic MLH1 P40692 A589I 589 A I 0.936 Pathogenic MLH1 P40692 A589K 589 A K 0.916 Pathogenic MLH1 P40692 A589L 589 A L 0.754 Pathogenic MLH1 P40692 A589M 589 A M 0.836 Pathogenic MLH1 P40692 A589N 589 A N 0.752 Pathogenic MLH1 P40692 A589P 589 A P 0.17 Neutral MLH1 P40692 A589Q 589 A Q 0.79 Pathogenic MLH1 P40692 A589R 589 A R 0.922 Pathogenic MLH1 P40692 A589S 589 A S 0.056 Neutral MLH1 P40692 A589T 589 A T 0.45 Neutral MLH1 P40692 A589V 589 A V 0.75 Pathogenic MLH1 P40692 A589W 589 A W 0.962 Pathogenic MLH1 P40692 A589Y 589 A Y 0.946 Pathogenic MLH1 P40692 I59A 59 I A 0.208 Neutral MLH1 P40692 I59C 59 I C 0.626 Pathogenic MLH1 P40692 I59D 59 I D 0.778 Pathogenic MLH1 P40692 I59E 59 I E 0.49 Neutral MLH1 P40692 I59F 59 I F 0.934 Pathogenic MLH1 P40692 I59G 59 I G 0.818 Pathogenic MLH1 P40692 I59H 59 I H 0.842 Pathogenic MLH1 P40692 I59K 59 I K 0.854 Pathogenic MLH1 P40692 I59L 59 I L 0.236 Neutral MLH1 P40692 I59M 59 I M 0.176 Neutral MLH1 P40692 I59N 59 I N 0.802 Pathogenic MLH1 P40692 I59P 59 I P 0.92 Pathogenic MLH1 P40692 I59Q 59 I Q 0.81 Pathogenic MLH1 P40692 I59R 59 I R 0.89 Pathogenic MLH1 P40692 I59S 59 I S 0.614 Pathogenic MLH1 P40692 I59T 59 I T 0.284 Neutral MLH1 P40692 I59V 59 I V 0.366 Neutral MLH1 P40692 I59W 59 I W 0.956 Pathogenic MLH1 P40692 I59Y 59 I Y 0.95 Pathogenic MLH1 P40692 L590A 590 L A 0.038 Neutral MLH1 P40692 L590C 590 L C 0.324 Neutral MLH1 P40692 L590D 590 L D 0.61 Pathogenic MLH1 P40692 L590E 590 L E 0.44 Neutral MLH1 P40692 L590F 590 L F 0.304 Neutral MLH1 P40692 L590G 590 L G 0.488 Neutral MLH1 P40692 L590H 590 L H 0.346 Neutral MLH1 P40692 L590I 590 L I 0.052 Neutral MLH1 P40692 L590K 590 L K 0.452 Neutral MLH1 P40692 L590M 590 L M 0.442 Neutral MLH1 P40692 L590N 590 L N 0.51 Pathogenic MLH1 P40692 L590P 590 L P 0.916 Pathogenic MLH1 P40692 L590Q 590 L Q 0.194 Neutral MLH1 P40692 L590R 590 L R 0.546 Pathogenic MLH1 P40692 L590S 590 L S 0.444 Neutral MLH1 P40692 L590T 590 L T 0.22 Neutral MLH1 P40692 L590V 590 L V 0.002 Neutral MLH1 P40692 L590W 590 L W 0.862 Pathogenic MLH1 P40692 L590Y 590 L Y 0.876 Pathogenic MLH1 P40692 D591A 591 D A 0.168 Neutral MLH1 P40692 D591C 591 D C 0.63 Pathogenic MLH1 P40692 D591E 591 D E 0.034 Neutral MLH1 P40692 D591F 591 D F 0.84 Pathogenic MLH1 P40692 D591G 591 D G 0.11 Neutral MLH1 P40692 D591H 591 D H 0.402 Neutral MLH1 P40692 D591I 591 D I 0.784 Pathogenic MLH1 P40692 D591K 591 D K 0.044 Neutral MLH1 P40692 D591L 591 D L 0.412 Neutral MLH1 P40692 D591M 591 D M 0.718 Pathogenic MLH1 P40692 D591N 591 D N 0.02 Neutral MLH1 P40692 D591P 591 D P 0.76 Pathogenic MLH1 P40692 D591Q 591 D Q 0.038 Neutral MLH1 P40692 D591R 591 D R 0.416 Neutral MLH1 P40692 D591S 591 D S 0.034 Neutral MLH1 P40692 D591T 591 D T 0.124 Neutral MLH1 P40692 D591V 591 D V 0.516 Pathogenic MLH1 P40692 D591W 591 D W 0.902 Pathogenic MLH1 P40692 D591Y 591 D Y 0.584 Pathogenic MLH1 P40692 S592A 592 S A 0.068 Neutral MLH1 P40692 S592C 592 S C 0.026 Neutral MLH1 P40692 S592D 592 S D 0.002 Neutral MLH1 P40692 S592E 592 S E 0.162 Neutral MLH1 P40692 S592F 592 S F 0.346 Neutral MLH1 P40692 S592G 592 S G 0.002 Neutral MLH1 P40692 S592H 592 S H 0.2 Neutral MLH1 P40692 S592I 592 S I 0.16 Neutral MLH1 P40692 S592K 592 S K 0.174 Neutral MLH1 P40692 S592L 592 S L 0.036 Neutral MLH1 P40692 S592M 592 S M 0.436 Neutral MLH1 P40692 S592N 592 S N 0 Neutral MLH1 P40692 S592P 592 S P 0.072 Neutral MLH1 P40692 S592Q 592 S Q 0.196 Neutral MLH1 P40692 S592R 592 S R 0.168 Neutral MLH1 P40692 S592T 592 S T 0.18 Neutral MLH1 P40692 S592V 592 S V 0.276 Neutral MLH1 P40692 S592W 592 S W 0.574 Pathogenic MLH1 P40692 S592Y 592 S Y 0.532 Pathogenic MLH1 P40692 P593A 593 P A 0.04 Neutral MLH1 P40692 P593C 593 P C 0.228 Neutral MLH1 P40692 P593D 593 P D 0.014 Neutral MLH1 P40692 P593E 593 P E 0.084 Neutral MLH1 P40692 P593F 593 P F 0.52 Pathogenic MLH1 P40692 P593G 593 P G 0.102 Neutral MLH1 P40692 P593H 593 P H 0.484 Neutral MLH1 P40692 P593I 593 P I 0.218 Neutral MLH1 P40692 P593K 593 P K 0.312 Neutral MLH1 P40692 P593L 593 P L 0.218 Neutral MLH1 P40692 P593M 593 P M 0.378 Neutral MLH1 P40692 P593N 593 P N 0.106 Neutral MLH1 P40692 P593Q 593 P Q 0.16 Neutral MLH1 P40692 P593R 593 P R 0.45 Neutral MLH1 P40692 P593S 593 P S 0.008 Neutral MLH1 P40692 P593T 593 P T 0.02 Neutral MLH1 P40692 P593V 593 P V 0.29 Neutral MLH1 P40692 P593W 593 P W 0.614 Pathogenic MLH1 P40692 P593Y 593 P Y 0.546 Pathogenic MLH1 P40692 E594A 594 E A 0.206 Neutral MLH1 P40692 E594C 594 E C 0.138 Neutral MLH1 P40692 E594D 594 E D 0.008 Neutral MLH1 P40692 E594F 594 E F 0.45 Neutral MLH1 P40692 E594G 594 E G 0.004 Neutral MLH1 P40692 E594H 594 E H 0.198 Neutral MLH1 P40692 E594I 594 E I 0.488 Neutral MLH1 P40692 E594K 594 E K 0.348 Neutral MLH1 P40692 E594L 594 E L 0.486 Neutral MLH1 P40692 E594M 594 E M 0.316 Neutral MLH1 P40692 E594N 594 E N 0.088 Neutral MLH1 P40692 E594P 594 E P 0.504 Pathogenic MLH1 P40692 E594Q 594 E Q 0.054 Neutral MLH1 P40692 E594R 594 E R 0.134 Neutral MLH1 P40692 E594S 594 E S 0.024 Neutral MLH1 P40692 E594T 594 E T 0.324 Neutral MLH1 P40692 E594V 594 E V 0.436 Neutral MLH1 P40692 E594W 594 E W 0.766 Pathogenic MLH1 P40692 E594Y 594 E Y 0.626 Pathogenic MLH1 P40692 S595A 595 S A 0.028 Neutral MLH1 P40692 S595C 595 S C 0.09 Neutral MLH1 P40692 S595D 595 S D 0.358 Neutral MLH1 P40692 S595E 595 S E 0.592 Pathogenic MLH1 P40692 S595F 595 S F 0.758 Pathogenic MLH1 P40692 S595G 595 S G 0.038 Neutral MLH1 P40692 S595H 595 S H 0.686 Pathogenic MLH1 P40692 S595I 595 S I 0.458 Neutral MLH1 P40692 S595K 595 S K 0.616 Pathogenic MLH1 P40692 S595L 595 S L 0.462 Neutral MLH1 P40692 S595M 595 S M 0.892 Pathogenic MLH1 P40692 S595N 595 S N 0.084 Neutral MLH1 P40692 S595P 595 S P 0.47 Neutral MLH1 P40692 S595Q 595 S Q 0.564 Pathogenic MLH1 P40692 S595R 595 S R 0.69 Pathogenic MLH1 P40692 S595T 595 S T 0.04 Neutral MLH1 P40692 S595V 595 S V 0.194 Neutral MLH1 P40692 S595W 595 S W 0.904 Pathogenic MLH1 P40692 S595Y 595 S Y 0.878 Pathogenic MLH1 P40692 G596A 596 G A 0.466 Neutral MLH1 P40692 G596C 596 G C 0.702 Pathogenic MLH1 P40692 G596D 596 G D 0.582 Pathogenic MLH1 P40692 G596E 596 G E 0.582 Pathogenic MLH1 P40692 G596F 596 G F 0.956 Pathogenic MLH1 P40692 G596H 596 G H 0.95 Pathogenic MLH1 P40692 G596I 596 G I 0.926 Pathogenic MLH1 P40692 G596K 596 G K 0.93 Pathogenic MLH1 P40692 G596L 596 G L 0.93 Pathogenic MLH1 P40692 G596M 596 G M 0.95 Pathogenic MLH1 P40692 G596N 596 G N 0.626 Pathogenic MLH1 P40692 G596P 596 G P 0.898 Pathogenic MLH1 P40692 G596Q 596 G Q 0.644 Pathogenic MLH1 P40692 G596R 596 G R 0.968 Pathogenic MLH1 P40692 G596S 596 G S 0.638 Pathogenic MLH1 P40692 G596T 596 G T 0.84 Pathogenic MLH1 P40692 G596V 596 G V 0.936 Pathogenic MLH1 P40692 G596W 596 G W 0.946 Pathogenic MLH1 P40692 G596Y 596 G Y 0.93 Pathogenic MLH1 P40692 W597A 597 W A 0.246 Neutral MLH1 P40692 W597C 597 W C 0.246 Neutral MLH1 P40692 W597D 597 W D 0.146 Neutral MLH1 P40692 W597E 597 W E 0.48 Neutral MLH1 P40692 W597F 597 W F 0.298 Neutral MLH1 P40692 W597G 597 W G 0.268 Neutral MLH1 P40692 W597H 597 W H 0.288 Neutral MLH1 P40692 W597I 597 W I 0.418 Neutral MLH1 P40692 W597K 597 W K 0.518 Pathogenic MLH1 P40692 W597L 597 W L 0.136 Neutral MLH1 P40692 W597M 597 W M 0.278 Neutral MLH1 P40692 W597N 597 W N 0.274 Neutral MLH1 P40692 W597P 597 W P 0.316 Neutral MLH1 P40692 W597Q 597 W Q 0.256 Neutral MLH1 P40692 W597R 597 W R 0.504 Pathogenic MLH1 P40692 W597S 597 W S 0.308 Neutral MLH1 P40692 W597T 597 W T 0.246 Neutral MLH1 P40692 W597V 597 W V 0.26 Neutral MLH1 P40692 W597Y 597 W Y 0.12 Neutral MLH1 P40692 T598A 598 T A 0.354 Neutral MLH1 P40692 T598C 598 T C 0.334 Neutral MLH1 P40692 T598D 598 T D 0.08 Neutral MLH1 P40692 T598E 598 T E 0.122 Neutral MLH1 P40692 T598F 598 T F 0.646 Pathogenic MLH1 P40692 T598G 598 T G 0.236 Neutral MLH1 P40692 T598H 598 T H 0.478 Neutral MLH1 P40692 T598I 598 T I 0.432 Neutral MLH1 P40692 T598K 598 T K 0.054 Neutral MLH1 P40692 T598L 598 T L 0.128 Neutral MLH1 P40692 T598M 598 T M 0.336 Neutral MLH1 P40692 T598N 598 T N 0.012 Neutral MLH1 P40692 T598P 598 T P 0.488 Neutral MLH1 P40692 T598Q 598 T Q 0.224 Neutral MLH1 P40692 T598R 598 T R 0.424 Neutral MLH1 P40692 T598S 598 T S 0.012 Neutral MLH1 P40692 T598V 598 T V 0.166 Neutral MLH1 P40692 T598W 598 T W 0.896 Pathogenic MLH1 P40692 T598Y 598 T Y 0.888 Pathogenic MLH1 P40692 E599A 599 E A 0.554 Pathogenic MLH1 P40692 E599C 599 E C 0.446 Neutral MLH1 P40692 E599D 599 E D 0.018 Neutral MLH1 P40692 E599F 599 E F 0.808 Pathogenic MLH1 P40692 E599G 599 E G 0.026 Neutral MLH1 P40692 E599H 599 E H 0.35 Neutral MLH1 P40692 E599I 599 E I 0.858 Pathogenic MLH1 P40692 E599K 599 E K 0.064 Neutral MLH1 P40692 E599L 599 E L 0.886 Pathogenic MLH1 P40692 E599M 599 E M 0.69 Pathogenic MLH1 P40692 E599N 599 E N 0.014 Neutral MLH1 P40692 E599P 599 E P 0.108 Neutral MLH1 P40692 E599Q 599 E Q 0.014 Neutral MLH1 P40692 E599R 599 E R 0.14 Neutral MLH1 P40692 E599S 599 E S 0.058 Neutral MLH1 P40692 E599T 599 E T 0.058 Neutral MLH1 P40692 E599V 599 E V 0.738 Pathogenic MLH1 P40692 E599W 599 E W 0.968 Pathogenic MLH1 P40692 E599Y 599 E Y 0.91 Pathogenic MLH1 P40692 G6A 6 G A 0.024 Neutral MLH1 P40692 G6C 6 G C 0.36 Neutral MLH1 P40692 G6D 6 G D 0.328 Neutral MLH1 P40692 G6E 6 G E 0.56 Pathogenic MLH1 P40692 G6F 6 G F 0.758 Pathogenic MLH1 P40692 G6H 6 G H 0.7 Pathogenic MLH1 P40692 G6I 6 G I 0.676 Pathogenic MLH1 P40692 G6K 6 G K 0.682 Pathogenic MLH1 P40692 G6L 6 G L 0.674 Pathogenic MLH1 P40692 G6M 6 G M 0.69 Pathogenic MLH1 P40692 G6N 6 G N 0.422 Neutral MLH1 P40692 G6P 6 G P 0.482 Neutral MLH1 P40692 G6Q 6 G Q 0.45 Neutral MLH1 P40692 G6R 6 G R 0.648 Pathogenic MLH1 P40692 G6S 6 G S 0.146 Neutral MLH1 P40692 G6T 6 G T 0.46 Neutral MLH1 P40692 G6V 6 G V 0.652 Pathogenic MLH1 P40692 G6W 6 G W 0.758 Pathogenic MLH1 P40692 G6Y 6 G Y 0.744 Pathogenic MLH1 P40692 Q60A 60 Q A 0.73 Pathogenic MLH1 P40692 Q60C 60 Q C 0.714 Pathogenic MLH1 P40692 Q60D 60 Q D 0.806 Pathogenic MLH1 P40692 Q60E 60 Q E 0.64 Pathogenic MLH1 P40692 Q60F 60 Q F 0.932 Pathogenic MLH1 P40692 Q60G 60 Q G 0.574 Pathogenic MLH1 P40692 Q60H 60 Q H 0.992 Pathogenic MLH1 P40692 Q60I 60 Q I 0.828 Pathogenic MLH1 P40692 Q60K 60 Q K 0.522 Pathogenic MLH1 P40692 Q60L 60 Q L 0.482 Neutral MLH1 P40692 Q60M 60 Q M 0.928 Pathogenic MLH1 P40692 Q60N 60 Q N 0.83 Pathogenic MLH1 P40692 Q60P 60 Q P 0.92 Pathogenic MLH1 P40692 Q60R 60 Q R 0.488 Neutral MLH1 P40692 Q60S 60 Q S 0.862 Pathogenic MLH1 P40692 Q60T 60 Q T 0.678 Pathogenic MLH1 P40692 Q60V 60 Q V 0.922 Pathogenic MLH1 P40692 Q60W 60 Q W 0.926 Pathogenic MLH1 P40692 Q60Y 60 Q Y 0.952 Pathogenic MLH1 P40692 E600A 600 E A 0.234 Neutral MLH1 P40692 E600C 600 E C 0.442 Neutral MLH1 P40692 E600D 600 E D 0.028 Neutral MLH1 P40692 E600F 600 E F 0.136 Neutral MLH1 P40692 E600G 600 E G 0.046 Neutral 1 MLH1 P40692 E600H 600 E H 0.652 Pathogenic MLH1 P40692 E600I 600 E I 0.236 Neutral MLH1 P40692 E600K 600 E K 0.38 Neutral MLH1 P40692 E600L 600 E L 0.138 Neutral MLH1 P40692 E600M 600 E M 0.66 Pathogenic MLH1 P40692 E600N 600 E N 0.026 Neutral MLH1 P40692 E600P 600 E P 0.136 Neutral MLH1 P40692 E600Q 600 E Q 0.264 Neutral MLH1 P40692 E600R 600 E R 0.47 Neutral MLH1 P40692 E600S 600 E S 0.036 Neutral MLH1 P40692 E600T 600 E T 0.06 Neutral MLH1 P40692 E600V 600 E V 0.502 Pathogenic MLH1 P40692 E600W 600 E W 0.94 Pathogenic MLH1 P40692 E600Y 600 E Y 0.864 Pathogenic MLH1 P40692 D601A 601 D A 0.364 Neutral MLH1 P40692 D601C 601 D C 0.754 Pathogenic MLH1 P40692 D601E 601 D E 0.042 Neutral MLH1 P40692 D601F 601 D F 0.594 Pathogenic MLH1 P40692 D601G 601 D G 0.066 Neutral MLH1 P40692 D601H 601 D H 0.446 Neutral MLH1 P40692 D601I 601 D I 0.21 Neutral MLH1 P40692 D601K 601 D K 0.362 Neutral MLH1 P40692 D601L 601 D L 0.112 Neutral MLH1 P40692 D601M 601 D M 0.82 Pathogenic MLH1 P40692 D601N 601 D N 0.03 Neutral MLH1 P40692 D601P 601 D P 0.726 Pathogenic MLH1 P40692 D601Q 601 D Q 0.03 Neutral MLH1 P40692 D601R 601 D R 0.514 Pathogenic MLH1 P40692 D601S 601 D S 0.028 Neutral MLH1 P40692 D601T 601 D T 0.128 Neutral MLH1 P40692 D601V 601 D V 0.144 Neutral MLH1 P40692 D601W 601 D W 0.974 Pathogenic MLH1 P40692 D601Y 601 D Y 0.968 Pathogenic MLH1 P40692 G602A 602 G A 0.456 Neutral MLH1 P40692 G602C 602 G C 0.72 Pathogenic MLH1 P40692 G602D 602 G D 0.46 Neutral MLH1 P40692 G602E 602 G E 0.544 Pathogenic MLH1 P40692 G602F 602 G F 0.974 Pathogenic MLH1 P40692 G602H 602 G H 0.662 Pathogenic MLH1 P40692 G602I 602 G I 0.698 Pathogenic MLH1 P40692 G602K 602 G K 0.608 Pathogenic MLH1 P40692 G602L 602 G L 0.776 Pathogenic MLH1 P40692 G602M 602 G M 0.926 Pathogenic MLH1 P40692 G602N 602 G N 0.49 Neutral MLH1 P40692 G602P 602 G P 0.636 Pathogenic MLH1 P40692 G602Q 602 G Q 0.55 Pathogenic MLH1 P40692 G602R 602 G R 0.916 Pathogenic MLH1 P40692 G602S 602 G S 0.184 Neutral MLH1 P40692 G602T 602 G T 0.596 Pathogenic MLH1 P40692 G602V 602 G V 0.62 Pathogenic MLH1 P40692 G602W 602 G W 0.95 Pathogenic MLH1 P40692 G602Y 602 G Y 0.936 Pathogenic MLH1 P40692 P603A 603 P A 0.076 Neutral MLH1 P40692 P603C 603 P C 0.138 Neutral MLH1 P40692 P603D 603 P D 0.04 Neutral MLH1 P40692 P603E 603 P E 0.128 Neutral MLH1 P40692 P603F 603 P F 0.58 Pathogenic MLH1 P40692 P603G 603 P G 0.098 Neutral MLH1 P40692 P603H 603 P H 0.62 Pathogenic MLH1 P40692 P603I 603 P I 0.132 Neutral MLH1 P40692 P603K 603 P K 0.114 Neutral MLH1 P40692 P603L 603 P L 0.084 Neutral MLH1 P40692 P603M 603 P M 0.2 Neutral MLH1 P40692 P603N 603 P N 0.286 Neutral MLH1 P40692 P603Q 603 P Q 0.632 Pathogenic MLH1 P40692 P603R 603 P R 0.738 Pathogenic 2 MLH1 P40692 P603S 603 P S 0.032 Neutral MLH1 P40692 P603T 603 P T 0.264 Neutral MLH1 P40692 P603V 603 P V 0.102 Neutral MLH1 P40692 P603W 603 P W 0.882 Pathogenic MLH1 P40692 P603Y 603 P Y 0.864 Pathogenic MLH1 P40692 K604A 604 K A 0.08 Neutral MLH1 P40692 K604C 604 K C 0.16 Neutral MLH1 P40692 K604D 604 K D 0.012 Neutral MLH1 P40692 K604E 604 K E 0.016 Neutral MLH1 P40692 K604F 604 K F 0.826 Pathogenic MLH1 P40692 K604G 604 K G 0.322 Neutral MLH1 P40692 K604H 604 K H 0.332 Neutral MLH1 P40692 K604I 604 K I 0.756 Pathogenic MLH1 P40692 K604L 604 K L 0.69 Pathogenic MLH1 P40692 K604M 604 K M 0.586 Pathogenic MLH1 P40692 K604N 604 K N 0.024 Neutral MLH1 P40692 K604P 604 K P 0.386 Neutral MLH1 P40692 K604Q 604 K Q 0.052 Neutral MLH1 P40692 K604R 604 K R 0.03 Neutral MLH1 P40692 K604S 604 K S 0.032 Neutral MLH1 P40692 K604T 604 K T 0.04 Neutral MLH1 P40692 K604V 604 K V 0.68 Pathogenic MLH1 P40692 K604W 604 K W 0.976 Pathogenic MLH1 P40692 K604Y 604 K Y 0.878 Pathogenic MLH1 P40692 E605A 605 E A 0.21 Neutral MLH1 P40692 E605C 605 E C 0.41 Neutral MLH1 P40692 E605D 605 E D 0.016 Neutral MLH1 P40692 E605F 605 E F 0.254 Neutral MLH1 P40692 E605G 605 E G 0.018 Neutral MLH1 P40692 E605H 605 E H 0.56 Pathogenic MLH1 P40692 E605I 605 E I 0.256 Neutral MLH1 P40692 E605K 605 E K 0.046 Neutral MLH1 P40692 E605L 605 E L 0.162 Neutral MLH1 P40692 E605M 605 E M 0.684 Pathogenic MLH1 P40692 E605N 605 E N 0.166 Neutral MLH1 P40692 E605P 605 E P 0.816 Pathogenic MLH1 P40692 E605Q 605 E Q 0.128 Neutral MLH1 P40692 E605R 605 E R 0.34 Neutral MLH1 P40692 E605S 605 E S 0.038 Neutral MLH1 P40692 E605T 605 E T 0.032 Neutral MLH1 P40692 E605V 605 E V 0.096 Neutral MLH1 P40692 E605W 605 E W 0.594 Pathogenic MLH1 P40692 E605Y 605 E Y 0.888 Pathogenic MLH1 P40692 G606A 606 G A 0.268 Neutral MLH1 P40692 G606C 606 G C 0.66 Pathogenic MLH1 P40692 G606D 606 G D 0.368 Neutral MLH1 P40692 G606E 606 G E 0.478 Neutral MLH1 P40692 G606F 606 G F 0.924 Pathogenic MLH1 P40692 G606H 606 G H 0.898 Pathogenic MLH1 P40692 G606I 606 G I 0.916 Pathogenic MLH1 P40692 G606K 606 G K 0.536 Pathogenic MLH1 P40692 G606L 606 G L 0.566 Pathogenic MLH1 P40692 G606M 606 G M 0.708 Pathogenic MLH1 P40692 G606N 606 G N 0.406 Neutral MLH1 P40692 G606P 606 G P 0.904 Pathogenic MLH1 P40692 G606Q 606 G Q 0.46 Neutral MLH1 P40692 G606R 606 G R 0.882 Pathogenic MLH1 P40692 G606S 606 G S 0.078 Neutral MLH1 P40692 G606T 606 G T 0.508 Pathogenic MLH1 P40692 G606V 606 G V 0.914 Pathogenic MLH1 P40692 G606W 606 G W 0.92 Pathogenic MLH1 P40692 G606Y 606 G Y 0.756 Pathogenic MLH1 P40692 L607A 607 L A 0.074 Neutral MLH1 P40692 L607C 607 L C 0.292 Neutral MLH1 P40692 L607D 607 L D 0.106 Neutral MLH1 P40692 L607E 607 L E 0.08 Neutral MLH1 P40692 L607F 607 L F 0.77 Pathogenic MLH1 P40692 L607G 607 L G 0.14 Neutral MLH1 P40692 L607H 607 L H 0.156 Neutral 2 MLH1 P40692 L607I 607 L I 0.072 Neutral MLH1 P40692 L607K 607 L K 0.054 Neutral MLH1 P40692 L607M 607 L M 0.036 Neutral MLH1 P40692 L607N 607 L N 0.29 Neutral MLH1 P40692 L607P 607 L P 0.842 Pathogenic MLH1 P40692 L607Q 607 L Q 0.202 Neutral MLH1 P40692 L607R 607 L R 0.762 Pathogenic MLH1 P40692 L607S 607 L S 0.064 Neutral MLH1 P40692 L607T 607 L T 0.056 Neutral MLH1 P40692 L607V 607 L V 0.022 Neutral MLH1 P40692 L607W 607 L W 0.836 Pathogenic MLH1 P40692 L607Y 607 L Y 0.83 Pathogenic MLH1 P40692 A608C 608 A C 0.69 Pathogenic MLH1 P40692 A608D 608 A D 0.918 Pathogenic 4 MLH1 P40692 A608E 608 A E 0.726 Pathogenic MLH1 P40692 A608F 608 A F 0.966 Pathogenic MLH1 P40692 A608G 608 A G 0.24 Neutral MLH1 P40692 A608H 608 A H 0.87 Pathogenic MLH1 P40692 A608I 608 A I 0.634 Pathogenic MLH1 P40692 A608K 608 A K 0.726 Pathogenic MLH1 P40692 A608L 608 A L 0.946 Pathogenic MLH1 P40692 A608M 608 A M 0.828 Pathogenic MLH1 P40692 A608N 608 A N 0.786 Pathogenic MLH1 P40692 A608P 608 A P 0.846 Pathogenic MLH1 P40692 A608Q 608 A Q 0.758 Pathogenic MLH1 P40692 A608R 608 A R 0.922 Pathogenic MLH1 P40692 A608S 608 A S 0.032 Neutral MLH1 P40692 A608T 608 A T 0.112 Neutral MLH1 P40692 A608V 608 A V 0.166 Neutral MLH1 P40692 A608W 608 A W 0.952 Pathogenic MLH1 P40692 A608Y 608 A Y 0.938 Pathogenic MLH1 P40692 E609A 609 E A 0.138 Neutral MLH1 P40692 E609C 609 E C 0.124 Neutral MLH1 P40692 E609D 609 E D 0.002 Neutral MLH1 P40692 E609F 609 E F 0.43 Neutral MLH1 P40692 E609G 609 E G 0.08 Neutral MLH1 P40692 E609H 609 E H 0.17 Neutral MLH1 P40692 E609I 609 E I 0.454 Neutral MLH1 P40692 E609K 609 E K 0.002 Neutral MLH1 P40692 E609L 609 E L 0.112 Neutral MLH1 P40692 E609M 609 E M 0.294 Neutral MLH1 P40692 E609N 609 E N 0.002 Neutral MLH1 P40692 E609P 609 E P 0.466 Neutral MLH1 P40692 E609Q 609 E Q 0 Neutral MLH1 P40692 E609R 609 E R 0.068 Neutral MLH1 P40692 E609S 609 E S 0.234 Neutral MLH1 P40692 E609T 609 E T 0.252 Neutral MLH1 P40692 E609V 609 E V 0.044 Neutral MLH1 P40692 E609W 609 E W 0.702 Pathogenic MLH1 P40692 E609Y 609 E Y 0.588 Pathogenic MLH1 P40692 I61A 61 I A 0.206 Neutral MLH1 P40692 I61C 61 I C 0.604 Pathogenic MLH1 P40692 I61D 61 I D 0.746 Pathogenic MLH1 P40692 I61E 61 I E 0.756 Pathogenic MLH1 P40692 I61F 61 I F 0.96 Pathogenic MLH1 P40692 I61G 61 I G 0.796 Pathogenic MLH1 P40692 I61H 61 I H 0.848 Pathogenic MLH1 P40692 I61K 61 I K 0.846 Pathogenic MLH1 P40692 I61L 61 I L 0.348 Neutral MLH1 P40692 I61M 61 I M 0.688 Pathogenic MLH1 P40692 I61N 61 I N 0.772 Pathogenic MLH1 P40692 I61P 61 I P 0.93 Pathogenic MLH1 P40692 I61Q 61 I Q 0.786 Pathogenic MLH1 P40692 I61R 61 I R 0.874 Pathogenic MLH1 P40692 I61S 61 I S 0.614 Pathogenic MLH1 P40692 I61T 61 I T 0.336 Neutral MLH1 P40692 I61V 61 I V 0.11 Neutral MLH1 P40692 I61W 61 I W 0.986 Pathogenic MLH1 P40692 I61Y 61 I Y 0.976 Pathogenic MLH1 P40692 Y610A 610 Y A 0.136 Neutral MLH1 P40692 Y610C 610 Y C 0.144 Neutral MLH1 P40692 Y610D 610 Y D 0.042 Neutral MLH1 P40692 Y610E 610 Y E 0.04 Neutral MLH1 P40692 Y610F 610 Y F 0.052 Neutral MLH1 P40692 Y610G 610 Y G 0.182 Neutral MLH1 P40692 Y610H 610 Y H 0.02 Neutral MLH1 P40692 Y610I 610 Y I 0.126 Neutral MLH1 P40692 Y610K 610 Y K 0.05 Neutral MLH1 P40692 Y610L 610 Y L 0.074 Neutral MLH1 P40692 Y610M 610 Y M 0.014 Neutral MLH1 P40692 Y610N 610 Y N 0.19 Neutral MLH1 P40692 Y610P 610 Y P 0.094 Neutral MLH1 P40692 Y610Q 610 Y Q 0.09 Neutral MLH1 P40692 Y610R 610 Y R 0.044 Neutral MLH1 P40692 Y610S 610 Y S 0.176 Neutral MLH1 P40692 Y610T 610 Y T 0.146 Neutral MLH1 P40692 Y610V 610 Y V 0.104 Neutral MLH1 P40692 Y610W 610 Y W 0.106 Neutral MLH1 P40692 I611A 611 I A 0.028 Neutral MLH1 P40692 I611C 611 I C 0.152 Neutral MLH1 P40692 I611D 611 I D 0.23 Neutral MLH1 P40692 I611E 611 I E 0.058 Neutral MLH1 P40692 I611F 611 I F 0.38 Neutral MLH1 P40692 I611G 611 I G 0.29 Neutral MLH1 P40692 I611H 611 I H 0.128 Neutral MLH1 P40692 I611K 611 I K 0.22 Neutral MLH1 P40692 I611L 611 I L 0.254 Neutral MLH1 P40692 I611M 611 I M 0.122 Neutral MLH1 P40692 I611N 611 I N 0.108 Neutral MLH1 P40692 I611P 611 I P 0.26 Neutral MLH1 P40692 I611Q 611 I Q 0.27 Neutral MLH1 P40692 I611R 611 I R 0.516 Pathogenic MLH1 P40692 I611S 611 I S 0.364 Neutral MLH1 P40692 I611T 611 I T 0.29 Neutral MLH1 P40692 I611V 611 I V 0 Neutral MLH1 P40692 I611W 611 I W 0.584 Pathogenic MLH1 P40692 I611Y 611 I Y 0.498 Neutral MLH1 P40692 V612A 612 V A 0.016 Neutral MLH1 P40692 V612C 612 V C 0.036 Neutral MLH1 P40692 V612D 612 V D 0.55 Pathogenic MLH1 P40692 V612E 612 V E 0.114 Neutral MLH1 P40692 V612F 612 V F 0.74 Pathogenic MLH1 P40692 V612G 612 V G 0.508 Pathogenic MLH1 P40692 V612H 612 V H 0.502 Pathogenic MLH1 P40692 V612I 612 V I 0.056 Neutral MLH1 P40692 V612K 612 V K 0.172 Neutral MLH1 P40692 V612L 612 V L 0.132 Neutral MLH1 P40692 V612M 612 V M 0.446 Neutral MLH1 P40692 V612N 612 V N 0.586 Pathogenic MLH1 P40692 V612P 612 V P 0.812 Pathogenic MLH1 P40692 V612Q 612 V Q 0.546 Pathogenic MLH1 P40692 V612R 612 V R 0.836 Pathogenic MLH1 P40692 V612S 612 V S 0.046 Neutral MLH1 P40692 V612T 612 V T 0.024 Neutral MLH1 P40692 V612W 612 V W 0.818 Pathogenic MLH1 P40692 V612Y 612 V Y 0.458 Neutral MLH1 P40692 E613A 613 E A 0.26 Neutral MLH1 P40692 E613C 613 E C 0.42 Neutral MLH1 P40692 E613D 613 E D 0.032 Neutral MLH1 P40692 E613F 613 E F 0.796 Pathogenic MLH1 P40692 E613G 613 E G 0.046 Neutral MLH1 P40692 E613H 613 E H 0.652 Pathogenic MLH1 P40692 E613I 613 E I 0.868 Pathogenic MLH1 P40692 E613K 613 E K 0.052 Neutral MLH1 P40692 E613L 613 E L 0.506 Pathogenic MLH1 P40692 E613M 613 E M 0.656 Pathogenic MLH1 P40692 E613N 613 E N 0.026 Neutral MLH1 P40692 E613P 613 E P 0.848 Pathogenic MLH1 P40692 E613Q 613 E Q 0.024 Neutral MLH1 P40692 E613R 613 E R 0.14 Neutral MLH1 P40692 E613S 613 E S 0.036 Neutral MLH1 P40692 E613T 613 E T 0.036 Neutral MLH1 P40692 E613V 613 E V 0.782 Pathogenic MLH1 P40692 E613W 613 E W 0.94 Pathogenic MLH1 P40692 E613Y 613 E Y 0.862 Pathogenic MLH1 P40692 F614A 614 F A 0.236 Neutral MLH1 P40692 F614C 614 F C 0.282 Neutral MLH1 P40692 F614D 614 F D 0.542 Pathogenic MLH1 P40692 F614E 614 F E 0.624 Pathogenic MLH1 P40692 F614G 614 F G 0.34 Neutral MLH1 P40692 F614H 614 F H 0.206 Neutral MLH1 P40692 F614I 614 F I 0.09 Neutral MLH1 P40692 F614K 614 F K 0.106 Neutral MLH1 P40692 F614L 614 F L 0.06 Neutral MLH1 P40692 F614M 614 F M 0.212 Neutral MLH1 P40692 F614N 614 F N 0.184 Neutral MLH1 P40692 F614P 614 F P 0.726 Pathogenic MLH1 P40692 F614Q 614 F Q 0.114 Neutral MLH1 P40692 F614R 614 F R 0.168 Neutral MLH1 P40692 F614S 614 F S 0.28 Neutral MLH1 P40692 F614T 614 F T 0.072 Neutral MLH1 P40692 F614V 614 F V 0.07 Neutral MLH1 P40692 F614W 614 F W 0.86 Pathogenic MLH1 P40692 F614Y 614 F Y 0.592 Pathogenic MLH1 P40692 L615A 615 L A 0.286 Neutral MLH1 P40692 L615C 615 L C 0.816 Pathogenic MLH1 P40692 L615D 615 L D 0.898 Pathogenic MLH1 P40692 L615E 615 L E 0.878 Pathogenic MLH1 P40692 L615F 615 L F 0.482 Neutral MLH1 P40692 L615G 615 L G 0.814 Pathogenic MLH1 P40692 L615H 615 L H 0.906 Pathogenic MLH1 P40692 L615I 615 L I 0.24 Neutral MLH1 P40692 L615K 615 L K 0.408 Neutral MLH1 P40692 L615M 615 L M 0.412 Neutral MLH1 P40692 L615N 615 L N 0.768 Pathogenic MLH1 P40692 L615P 615 L P 0.992 Pathogenic MLH1 P40692 L615Q 615 L Q 0.734 Pathogenic MLH1 P40692 L615R 615 L R 0.984 Pathogenic MLH1 P40692 L615S 615 L S 0.644 Pathogenic MLH1 P40692 L615T 615 L T 0.61 Pathogenic MLH1 P40692 L615V 615 L V 0.08 Neutral MLH1 P40692 L615W 615 L W 0.93 Pathogenic MLH1 P40692 L615Y 615 L Y 0.896 Pathogenic MLH1 P40692 K616A 616 K A 0.13 Neutral MLH1 P40692 K616C 616 K C 0.106 Neutral MLH1 P40692 K616D 616 K D 0.146 Neutral MLH1 P40692 K616E 616 K E 0.138 Neutral MLH1 P40692 K616F 616 K F 0.068 Neutral MLH1 P40692 K616G 616 K G 0.056 Neutral MLH1 P40692 K616H 616 K H 0.016 Neutral MLH1 P40692 K616I 616 K I 0.072 Neutral MLH1 P40692 K616L 616 K L 0.058 Neutral MLH1 P40692 K616M 616 K M 0.034 Neutral MLH1 P40692 K616N 616 K N 0.104 Neutral MLH1 P40692 K616P 616 K P 0.512 Pathogenic MLH1 P40692 K616Q 616 K Q 0.014 Neutral MLH1 P40692 K616R 616 K R 0.07 Neutral MLH1 P40692 K616S 616 K S 0.026 Neutral MLH1 P40692 K616T 616 K T 0.024 Neutral MLH1 P40692 K616V 616 K V 0.052 Neutral MLH1 P40692 K616W 616 K W 0.466 Neutral MLH1 P40692 K616Y 616 K Y 0.424 Neutral MLH1 P40692 K617A 617 K A 0.076 Neutral MLH1 P40692 K617C 617 K C 0.224 Neutral MLH1 P40692 K617D 617 K D 0.024 Neutral MLH1 P40692 K617E 617 K E 0.026 Neutral MLH1 P40692 K617F 617 K F 0.728 Pathogenic MLH1 P40692 K617G 617 K G 0.098 Neutral MLH1 P40692 K617H 617 K H 0.276 Neutral MLH1 P40692 K617I 617 K I 0.772 Pathogenic MLH1 P40692 K617L 617 K L 0.41 Neutral MLH1 P40692 K617M 617 K M 0.3 Neutral MLH1 P40692 K617N 617 K N 0.072 Neutral MLH1 P40692 K617P 617 K P 0.754 Pathogenic MLH1 P40692 K617Q 617 K Q 0.036 Neutral MLH1 P40692 K617R 617 K R 0.026 Neutral MLH1 P40692 K617S 617 K S 0.038 Neutral MLH1 P40692 K617T 617 K T 0.044 Neutral MLH1 P40692 K617V 617 K V 0.712 Pathogenic MLH1 P40692 K617W 617 K W 0.914 Pathogenic MLH1 P40692 K617Y 617 K Y 0.85 Pathogenic MLH1 P40692 K618A 618 K A 0.07 Neutral 1 MLH1 P40692 K618C 618 K C 0.21 Neutral MLH1 P40692 K618D 618 K D 0.092 Neutral MLH1 P40692 K618E 618 K E 0.406 Neutral MLH1 P40692 K618F 618 K F 0.79 Pathogenic MLH1 P40692 K618G 618 K G 0.354 Neutral MLH1 P40692 K618H 618 K H 0.036 Neutral MLH1 P40692 K618I 618 K I 0.854 Pathogenic MLH1 P40692 K618L 618 K L 0.372 Neutral MLH1 P40692 K618M 618 K M 0.06 Neutral MLH1 P40692 K618N 618 K N 0.028 Neutral MLH1 P40692 K618P 618 K P 0.762 Pathogenic MLH1 P40692 K618Q 618 K Q 0.034 Neutral MLH1 P40692 K618R 618 K R 0.052 Neutral 2 MLH1 P40692 K618S 618 K S 0.386 Neutral MLH1 P40692 K618T 618 K T 0.216 Neutral 1 MLH1 P40692 K618V 618 K V 0.698 Pathogenic MLH1 P40692 K618W 618 K W 0.936 Pathogenic MLH1 P40692 K618Y 618 K Y 0.884 Pathogenic MLH1 P40692 A619C 619 A C 0.718 Pathogenic MLH1 P40692 A619D 619 A D 0.856 Pathogenic MLH1 P40692 A619E 619 A E 0.72 Pathogenic MLH1 P40692 A619F 619 A F 0.968 Pathogenic MLH1 P40692 A619G 619 A G 0.028 Neutral MLH1 P40692 A619H 619 A H 0.872 Pathogenic MLH1 P40692 A619I 619 A I 0.93 Pathogenic MLH1 P40692 A619K 619 A K 0.56 Pathogenic MLH1 P40692 A619L 619 A L 0.948 Pathogenic MLH1 P40692 A619M 619 A M 0.838 Pathogenic MLH1 P40692 A619N 619 A N 0.782 Pathogenic MLH1 P40692 A619P 619 A P 0.472 Neutral MLH1 P40692 A619Q 619 A Q 0.796 Pathogenic MLH1 P40692 A619R 619 A R 0.632 Pathogenic MLH1 P40692 A619S 619 A S 0.02 Neutral MLH1 P40692 A619T 619 A T 0.052 Neutral MLH1 P40692 A619V 619 A V 0.722 Pathogenic MLH1 P40692 A619W 619 A W 0.954 Pathogenic MLH1 P40692 A619Y 619 A Y 0.94 Pathogenic MLH1 P40692 Q62A 62 Q A 0.142 Neutral MLH1 P40692 Q62C 62 Q C 0.5 Pathogenic MLH1 P40692 Q62D 62 Q D 0.56 Pathogenic MLH1 P40692 Q62E 62 Q E 0.576 Pathogenic MLH1 P40692 Q62F 62 Q F 0.842 Pathogenic MLH1 P40692 Q62G 62 Q G 0.454 Neutral MLH1 P40692 Q62H 62 Q H 0.804 Pathogenic MLH1 P40692 Q62I 62 Q I 0.894 Pathogenic MLH1 P40692 Q62K 62 Q K 0.78 Pathogenic MLH1 P40692 Q62L 62 Q L 0.446 Neutral MLH1 P40692 Q62M 62 Q M 0.732 Pathogenic MLH1 P40692 Q62N 62 Q N 0.61 Pathogenic MLH1 P40692 Q62P 62 Q P 0.844 Pathogenic MLH1 P40692 Q62R 62 Q R 0.4 Neutral MLH1 P40692 Q62S 62 Q S 0.084 Neutral MLH1 P40692 Q62T 62 Q T 0.028 Neutral MLH1 P40692 Q62V 62 Q V 0.364 Neutral MLH1 P40692 Q62W 62 Q W 0.918 Pathogenic MLH1 P40692 Q62Y 62 Q Y 0.888 Pathogenic MLH1 P40692 E620A 620 E A 0.23 Neutral MLH1 P40692 E620C 620 E C 0.48 Neutral MLH1 P40692 E620D 620 E D 0.022 Neutral MLH1 P40692 E620F 620 E F 0.828 Pathogenic MLH1 P40692 E620G 620 E G 0.05 Neutral MLH1 P40692 E620H 620 E H 0.548 Pathogenic MLH1 P40692 E620I 620 E I 0.888 Pathogenic MLH1 P40692 E620K 620 E K 0.678 Pathogenic MLH1 P40692 E620L 620 E L 0.726 Pathogenic MLH1 P40692 E620M 620 E M 0.654 Pathogenic MLH1 P40692 E620N 620 E N 0.086 Neutral MLH1 P40692 E620P 620 E P 0.146 Neutral MLH1 P40692 E620Q 620 E Q 0.014 Neutral MLH1 P40692 E620R 620 E R 0.298 Neutral MLH1 P40692 E620S 620 E S 0.058 Neutral MLH1 P40692 E620T 620 E T 0.202 Neutral MLH1 P40692 E620V 620 E V 0.394 Neutral MLH1 P40692 E620W 620 E W 0.936 Pathogenic MLH1 P40692 E620Y 620 E Y 0.882 Pathogenic MLH1 P40692 M621A 621 M A 0.222 Neutral MLH1 P40692 M621C 621 M C 0.518 Pathogenic MLH1 P40692 M621D 621 M D 0.25 Neutral MLH1 P40692 M621E 621 M E 0.172 Neutral MLH1 P40692 M621F 621 M F 0.85 Pathogenic MLH1 P40692 M621G 621 M G 0.514 Pathogenic MLH1 P40692 M621H 621 M H 0.87 Pathogenic MLH1 P40692 M621I 621 M I 0.288 Neutral MLH1 P40692 M621K 621 M K 0.92 Pathogenic MLH1 P40692 M621L 621 M L 0.212 Neutral MLH1 P40692 M621N 621 M N 0.87 Pathogenic MLH1 P40692 M621P 621 M P 0.916 Pathogenic MLH1 P40692 M621Q 621 M Q 0.718 Pathogenic MLH1 P40692 M621R 621 M R 0.94 Pathogenic MLH1 P40692 M621S 621 M S 0.85 Pathogenic MLH1 P40692 M621T 621 M T 0.718 Pathogenic MLH1 P40692 M621V 621 M V 0.224 Neutral MLH1 P40692 M621W 621 M W 0.986 Pathogenic MLH1 P40692 M621Y 621 M Y 0.962 Pathogenic MLH1 P40692 L622A 622 L A 0.632 Pathogenic MLH1 P40692 L622C 622 L C 0.756 Pathogenic MLH1 P40692 L622D 622 L D 0.882 Pathogenic MLH1 P40692 L622E 622 L E 0.87 Pathogenic MLH1 P40692 L622F 622 L F 0.512 Pathogenic MLH1 P40692 L622G 622 L G 0.79 Pathogenic MLH1 P40692 L622H 622 L H 0.882 Pathogenic 5 MLH1 P40692 L622I 622 L I 0.24 Neutral MLH1 P40692 L622K 622 L K 0.74 Pathogenic MLH1 P40692 L622M 622 L M 0.18 Neutral MLH1 P40692 L622N 622 L N 0.748 Pathogenic MLH1 P40692 L622P 622 L P 0.982 Pathogenic MLH1 P40692 L622Q 622 L Q 0.682 Pathogenic MLH1 P40692 L622R 622 L R 0.71 Pathogenic MLH1 P40692 L622S 622 L S 0.6 Pathogenic MLH1 P40692 L622T 622 L T 0.33 Neutral MLH1 P40692 L622V 622 L V 0.534 Pathogenic MLH1 P40692 L622W 622 L W 0.94 Pathogenic MLH1 P40692 L622Y 622 L Y 0.676 Pathogenic MLH1 P40692 A623C 623 A C 0.32 Neutral MLH1 P40692 A623D 623 A D 0.436 Neutral MLH1 P40692 A623E 623 A E 0.372 Neutral MLH1 P40692 A623F 623 A F 0.388 Neutral MLH1 P40692 A623G 623 A G 0.006 Neutral MLH1 P40692 A623H 623 A H 0.498 Neutral MLH1 P40692 A623I 623 A I 0.542 Pathogenic MLH1 P40692 A623K 623 A K 0.358 Neutral MLH1 P40692 A623L 623 A L 0.402 Neutral MLH1 P40692 A623M 623 A M 0.454 Neutral MLH1 P40692 A623N 623 A N 0.39 Neutral MLH1 P40692 A623P 623 A P 0.458 Neutral MLH1 P40692 A623Q 623 A Q 0.334 Neutral MLH1 P40692 A623R 623 A R 0.394 Neutral MLH1 P40692 A623S 623 A S 0.006 Neutral MLH1 P40692 A623T 623 A T 0.028 Neutral MLH1 P40692 A623V 623 A V 0.42 Neutral MLH1 P40692 A623W 623 A W 0.476 Neutral MLH1 P40692 A623Y 623 A Y 0.74 Pathogenic MLH1 P40692 D624A 624 D A 0.334 Neutral MLH1 P40692 D624C 624 D C 0.886 Pathogenic MLH1 P40692 D624E 624 D E 0.33 Neutral MLH1 P40692 D624F 624 D F 0.982 Pathogenic MLH1 P40692 D624G 624 D G 0.862 Pathogenic MLH1 P40692 D624H 624 D H 0.59 Pathogenic MLH1 P40692 D624I 624 D I 0.798 Pathogenic MLH1 P40692 D624K 624 D K 0.956 Pathogenic MLH1 P40692 D624L 624 D L 0.974 Pathogenic MLH1 P40692 D624M 624 D M 0.93 Pathogenic MLH1 P40692 D624N 624 D N 0.222 Neutral MLH1 P40692 D624P 624 D P 0.902 Pathogenic MLH1 P40692 D624Q 624 D Q 0.23 Neutral MLH1 P40692 D624R 624 D R 0.888 Pathogenic MLH1 P40692 D624S 624 D S 0.118 Neutral MLH1 P40692 D624T 624 D T 0.812 Pathogenic MLH1 P40692 D624V 624 D V 0.518 Pathogenic MLH1 P40692 D624W 624 D W 0.986 Pathogenic MLH1 P40692 D624Y 624 D Y 0.98 Pathogenic MLH1 P40692 Y625A 625 Y A 0.436 Neutral MLH1 P40692 Y625C 625 Y C 0.678 Pathogenic MLH1 P40692 Y625D 625 Y D 0.836 Pathogenic MLH1 P40692 Y625E 625 Y E 0.736 Pathogenic MLH1 P40692 Y625F 625 Y F 0.34 Neutral MLH1 P40692 Y625G 625 Y G 0.484 Neutral MLH1 P40692 Y625H 625 Y H 0.27 Neutral MLH1 P40692 Y625I 625 Y I 0.244 Neutral MLH1 P40692 Y625K 625 Y K 0.82 Pathogenic MLH1 P40692 Y625L 625 Y L 0.254 Neutral MLH1 P40692 Y625M 625 Y M 0.676 Pathogenic MLH1 P40692 Y625N 625 Y N 0.304 Neutral MLH1 P40692 Y625P 625 Y P 0.792 Pathogenic MLH1 P40692 Y625Q 625 Y Q 0.35 Neutral MLH1 P40692 Y625R 625 Y R 0.752 Pathogenic MLH1 P40692 Y625S 625 Y S 0.484 Neutral MLH1 P40692 Y625T 625 Y T 0.674 Pathogenic MLH1 P40692 Y625V 625 Y V 0.68 Pathogenic MLH1 P40692 Y625W 625 Y W 0.908 Pathogenic MLH1 P40692 F626A 626 F A 0.506 Pathogenic MLH1 P40692 F626C 626 F C 0.71 Pathogenic MLH1 P40692 F626D 626 F D 0.794 Pathogenic MLH1 P40692 F626E 626 F E 0.854 Pathogenic MLH1 P40692 F626G 626 F G 0.488 Neutral MLH1 P40692 F626H 626 F H 0.758 Pathogenic MLH1 P40692 F626I 626 F I 0.296 Neutral MLH1 P40692 F626K 626 F K 0.482 Neutral MLH1 P40692 F626L 626 F L 0.176 Neutral MLH1 P40692 F626M 626 F M 0.776 Pathogenic MLH1 P40692 F626N 626 F N 0.166 Neutral MLH1 P40692 F626P 626 F P 0.956 Pathogenic MLH1 P40692 F626Q 626 F Q 0.448 Neutral MLH1 P40692 F626R 626 F R 0.538 Pathogenic MLH1 P40692 F626S 626 F S 0.816 Pathogenic MLH1 P40692 F626T 626 F T 0.588 Pathogenic MLH1 P40692 F626V 626 F V 0.844 Pathogenic MLH1 P40692 F626W 626 F W 0.92 Pathogenic MLH1 P40692 F626Y 626 F Y 0.242 Neutral MLH1 P40692 S627A 627 S A 0.178 Neutral MLH1 P40692 S627C 627 S C 0.248 Neutral MLH1 P40692 S627D 627 S D 0.796 Pathogenic MLH1 P40692 S627E 627 S E 0.908 Pathogenic MLH1 P40692 S627F 627 S F 0.978 Pathogenic MLH1 P40692 S627G 627 S G 0.08 Neutral MLH1 P40692 S627H 627 S H 0.922 Pathogenic MLH1 P40692 S627I 627 S I 0.664 Pathogenic MLH1 P40692 S627K 627 S K 0.896 Pathogenic MLH1 P40692 S627L 627 S L 0.874 Pathogenic MLH1 P40692 S627M 627 S M 0.994 Pathogenic MLH1 P40692 S627N 627 S N 0.206 Neutral MLH1 P40692 S627P 627 S P 0.912 Pathogenic MLH1 P40692 S627Q 627 S Q 0.508 Pathogenic MLH1 P40692 S627R 627 S R 0.706 Pathogenic MLH1 P40692 S627T 627 S T 0.732 Pathogenic MLH1 P40692 S627V 627 S V 0.784 Pathogenic MLH1 P40692 S627W 627 S W 0.968 Pathogenic MLH1 P40692 S627Y 627 S Y 0.916 Pathogenic MLH1 P40692 L628A 628 L A 0.314 Neutral MLH1 P40692 L628C 628 L C 0.402 Neutral MLH1 P40692 L628D 628 L D 0.508 Pathogenic MLH1 P40692 L628E 628 L E 0.424 Neutral MLH1 P40692 L628F 628 L F 0.272 Neutral MLH1 P40692 L628G 628 L G 0.128 Neutral MLH1 P40692 L628H 628 L H 0.424 Neutral MLH1 P40692 L628I 628 L I 0.026 Neutral MLH1 P40692 L628K 628 L K 0.484 Neutral MLH1 P40692 L628M 628 L M 0.01 Neutral MLH1 P40692 L628N 628 L N 0.48 Neutral MLH1 P40692 L628P 628 L P 0.954 Pathogenic MLH1 P40692 L628Q 628 L Q 0.364 Neutral MLH1 P40692 L628R 628 L R 0.872 Pathogenic MLH1 P40692 L628S 628 L S 0.402 Neutral MLH1 P40692 L628T 628 L T 0.388 Neutral MLH1 P40692 L628V 628 L V 0.002 Neutral MLH1 P40692 L628W 628 L W 0.848 Pathogenic MLH1 P40692 L628Y 628 L Y 0.84 Pathogenic MLH1 P40692 E629A 629 E A 0.492 Neutral MLH1 P40692 E629C 629 E C 0.074 Neutral MLH1 P40692 E629D 629 E D 0.016 Neutral MLH1 P40692 E629F 629 E F 0.446 Neutral MLH1 P40692 E629G 629 E G 0.026 Neutral MLH1 P40692 E629H 629 E H 0.044 Neutral MLH1 P40692 E629I 629 E I 0.228 Neutral MLH1 P40692 E629K 629 E K 0.028 Neutral MLH1 P40692 E629L 629 E L 0.812 Pathogenic MLH1 P40692 E629M 629 E M 0.664 Pathogenic MLH1 P40692 E629N 629 E N 0.014 Neutral MLH1 P40692 E629P 629 E P 0.138 Neutral MLH1 P40692 E629Q 629 E Q 0.012 Neutral MLH1 P40692 E629R 629 E R 0.076 Neutral MLH1 P40692 E629S 629 E S 0.046 Neutral MLH1 P40692 E629T 629 E T 0.056 Neutral MLH1 P40692 E629V 629 E V 0.074 Neutral MLH1 P40692 E629W 629 E W 0.918 Pathogenic MLH1 P40692 E629Y 629 E Y 0.34 Neutral MLH1 P40692 D63A 63 D A 0.778 Pathogenic MLH1 P40692 D63C 63 D C 0.91 Pathogenic MLH1 P40692 D63E 63 D E 0.946 Pathogenic 5 MLH1 P40692 D63F 63 D F 0.986 Pathogenic MLH1 P40692 D63G 63 D G 0.936 Pathogenic MLH1 P40692 D63H 63 D H 0.636 Pathogenic MLH1 P40692 D63I 63 D I 0.972 Pathogenic MLH1 P40692 D63K 63 D K 0.982 Pathogenic MLH1 P40692 D63L 63 D L 0.978 Pathogenic MLH1 P40692 D63M 63 D M 0.962 Pathogenic MLH1 P40692 D63N 63 D N 0.344 Neutral MLH1 P40692 D63P 63 D P 0.904 Pathogenic MLH1 P40692 D63Q 63 D Q 0.738 Pathogenic MLH1 P40692 D63R 63 D R 0.678 Pathogenic MLH1 P40692 D63S 63 D S 0.248 Neutral MLH1 P40692 D63T 63 D T 0.838 Pathogenic MLH1 P40692 D63V 63 D V 0.992 Pathogenic MLH1 P40692 D63W 63 D W 0.984 Pathogenic MLH1 P40692 D63Y 63 D Y 0.978 Pathogenic MLH1 P40692 I630A 630 I A 0.206 Neutral MLH1 P40692 I630C 630 I C 0.61 Pathogenic MLH1 P40692 I630D 630 I D 0.478 Neutral MLH1 P40692 I630E 630 I E 0.76 Pathogenic MLH1 P40692 I630F 630 I F 0.314 Neutral MLH1 P40692 I630G 630 I G 0.802 Pathogenic MLH1 P40692 I630H 630 I H 0.85 Pathogenic MLH1 P40692 I630K 630 I K 0.85 Pathogenic MLH1 P40692 I630L 630 I L 0.102 Neutral MLH1 P40692 I630M 630 I M 0.194 Neutral MLH1 P40692 I630N 630 I N 0.204 Neutral MLH1 P40692 I630P 630 I P 0.938 Pathogenic MLH1 P40692 I630Q 630 I Q 0.792 Pathogenic MLH1 P40692 I630R 630 I R 0.874 Pathogenic MLH1 P40692 I630S 630 I S 0.62 Pathogenic MLH1 P40692 I630T 630 I T 0.34 Neutral MLH1 P40692 I630V 630 I V 0.124 Neutral MLH1 P40692 I630W 630 I W 0.986 Pathogenic MLH1 P40692 I630Y 630 I Y 0.976 Pathogenic MLH1 P40692 D631A 631 D A 0.198 Neutral MLH1 P40692 D631C 631 D C 0.678 Pathogenic MLH1 P40692 D631E 631 D E 0.304 Neutral MLH1 P40692 D631F 631 D F 0.938 Pathogenic MLH1 P40692 D631G 631 D G 0.07 Neutral MLH1 P40692 D631H 631 D H 0.46 Neutral MLH1 P40692 D631I 631 D I 0.33 Neutral MLH1 P40692 D631K 631 D K 0.192 Neutral MLH1 P40692 D631L 631 D L 0.916 Pathogenic MLH1 P40692 D631M 631 D M 0.822 Pathogenic MLH1 P40692 D631N 631 D N 0.014 Neutral MLH1 P40692 D631P 631 D P 0.828 Pathogenic MLH1 P40692 D631Q 631 D Q 0.492 Neutral MLH1 P40692 D631R 631 D R 0.512 Pathogenic MLH1 P40692 D631S 631 D S 0.02 Neutral MLH1 P40692 D631T 631 D T 0.054 Neutral MLH1 P40692 D631V 631 D V 0.296 Neutral MLH1 P40692 D631W 631 D W 0.972 Pathogenic MLH1 P40692 D631Y 631 D Y 0.946 Pathogenic MLH1 P40692 E632A 632 E A 0.084 Neutral MLH1 P40692 E632C 632 E C 0.126 Neutral MLH1 P40692 E632D 632 E D 0.002 Neutral MLH1 P40692 E632F 632 E F 0.432 Neutral MLH1 P40692 E632G 632 E G 0 Neutral MLH1 P40692 E632H 632 E H 0.054 Neutral MLH1 P40692 E632I 632 E I 0.342 Neutral MLH1 P40692 E632K 632 E K 0.002 Neutral MLH1 P40692 E632L 632 E L 0.064 Neutral MLH1 P40692 E632M 632 E M 0.026 Neutral MLH1 P40692 E632N 632 E N 0.002 Neutral MLH1 P40692 E632P 632 E P 0.484 Neutral MLH1 P40692 E632Q 632 E Q 0 Neutral MLH1 P40692 E632R 632 E R 0.076 Neutral MLH1 P40692 E632S 632 E S 0.018 Neutral MLH1 P40692 E632T 632 E T 0.034 Neutral MLH1 P40692 E632V 632 E V 0.414 Neutral MLH1 P40692 E632W 632 E W 0.696 Pathogenic MLH1 P40692 E632Y 632 E Y 0.582 Pathogenic MLH1 P40692 E633A 633 E A 0.188 Neutral MLH1 P40692 E633C 633 E C 0.018 Neutral MLH1 P40692 E633D 633 E D 0.002 Neutral MLH1 P40692 E633F 633 E F 0.436 Neutral MLH1 P40692 E633G 633 E G 0 Neutral MLH1 P40692 E633H 633 E H 0.126 Neutral MLH1 P40692 E633I 633 E I 0.148 Neutral MLH1 P40692 E633K 633 E K 0.002 Neutral MLH1 P40692 E633L 633 E L 0.058 Neutral MLH1 P40692 E633M 633 E M 0.298 Neutral MLH1 P40692 E633N 633 E N 0.002 Neutral MLH1 P40692 E633P 633 E P 0.47 Neutral MLH1 P40692 E633Q 633 E Q 0.004 Neutral MLH1 P40692 E633R 633 E R 0.022 Neutral MLH1 P40692 E633S 633 E S 0.016 Neutral MLH1 P40692 E633T 633 E T 0.028 Neutral MLH1 P40692 E633V 633 E V 0.048 Neutral MLH1 P40692 E633W 633 E W 0.708 Pathogenic MLH1 P40692 E633Y 633 E Y 0.594 Pathogenic MLH1 P40692 G634A 634 G A 0.012 Neutral MLH1 P40692 G634C 634 G C 0.45 Neutral MLH1 P40692 G634D 634 G D 0.506 Pathogenic MLH1 P40692 G634E 634 G E 0.394 Neutral MLH1 P40692 G634F 634 G F 0.83 Pathogenic MLH1 P40692 G634H 634 G H 0.774 Pathogenic MLH1 P40692 G634I 634 G I 0.654 Pathogenic MLH1 P40692 G634K 634 G K 0.496 Neutral MLH1 P40692 G634L 634 G L 0.746 Pathogenic MLH1 P40692 G634M 634 G M 0.712 Pathogenic MLH1 P40692 G634N 634 G N 0.498 Neutral MLH1 P40692 G634P 634 G P 0.772 Pathogenic MLH1 P40692 G634Q 634 G Q 0.362 Neutral MLH1 P40692 G634R 634 G R 0.748 Pathogenic MLH1 P40692 G634S 634 G S 0.032 Neutral MLH1 P40692 G634T 634 G T 0.446 Neutral MLH1 P40692 G634V 634 G V 0.502 Pathogenic MLH1 P40692 G634W 634 G W 0.832 Pathogenic MLH1 P40692 G634Y 634 G Y 0.816 Pathogenic MLH1 P40692 N635A 635 N A 0.178 Neutral MLH1 P40692 N635C 635 N C 0.028 Neutral MLH1 P40692 N635D 635 N D 0.092 Neutral MLH1 P40692 N635E 635 N E 0.016 Neutral MLH1 P40692 N635F 635 N F 0.348 Neutral MLH1 P40692 N635G 635 N G 0.22 Neutral MLH1 P40692 N635H 635 N H 0.024 Neutral MLH1 P40692 N635I 635 N I 0.434 Neutral MLH1 P40692 N635K 635 N K 0.042 Neutral MLH1 P40692 N635L 635 N L 0.106 Neutral MLH1 P40692 N635M 635 N M 0.044 Neutral MLH1 P40692 N635P 635 N P 0.394 Neutral MLH1 P40692 N635Q 635 N Q 0.018 Neutral MLH1 P40692 N635R 635 N R 0.254 Neutral MLH1 P40692 N635S 635 N S 0.006 Neutral MLH1 P40692 N635T 635 N T 0.008 Neutral MLH1 P40692 N635V 635 N V 0.424 Neutral MLH1 P40692 N635W 635 N W 0.718 Pathogenic MLH1 P40692 N635Y 635 N Y 0.556 Pathogenic MLH1 P40692 L636A 636 L A 0.306 Neutral MLH1 P40692 L636C 636 L C 0.392 Neutral MLH1 P40692 L636D 636 L D 0.512 Pathogenic MLH1 P40692 L636E 636 L E 0.622 Pathogenic MLH1 P40692 L636F 636 L F 0.8 Pathogenic MLH1 P40692 L636G 636 L G 0.58 Pathogenic MLH1 P40692 L636H 636 L H 0.418 Neutral MLH1 P40692 L636I 636 L I 0.036 Neutral MLH1 P40692 L636K 636 L K 0.48 Neutral MLH1 P40692 L636M 636 L M 0.402 Neutral MLH1 P40692 L636N 636 L N 0.614 Pathogenic MLH1 P40692 L636P 636 L P 0.96 Pathogenic MLH1 P40692 L636Q 636 L Q 0.36 Neutral MLH1 P40692 L636R 636 L R 0.866 Pathogenic MLH1 P40692 L636S 636 L S 0.4 Neutral MLH1 P40692 L636T 636 L T 0.382 Neutral MLH1 P40692 L636V 636 L V 0.002 Neutral MLH1 P40692 L636W 636 L W 0.852 Pathogenic MLH1 P40692 L636Y 636 L Y 0.842 Pathogenic MLH1 P40692 I637A 637 I A 0.006 Neutral MLH1 P40692 I637C 637 I C 0.012 Neutral MLH1 P40692 I637D 637 I D 0.15 Neutral MLH1 P40692 I637E 637 I E 0.032 Neutral MLH1 P40692 I637F 637 I F 0.25 Neutral MLH1 P40692 I637G 637 I G 0.212 Neutral MLH1 P40692 I637H 637 I H 0.052 Neutral MLH1 P40692 I637K 637 I K 0.046 Neutral MLH1 P40692 I637L 637 I L 0 Neutral MLH1 P40692 I637M 637 I M 0.038 Neutral MLH1 P40692 I637N 637 I N 0.116 Neutral MLH1 P40692 I637P 637 I P 0.076 Neutral MLH1 P40692 I637Q 637 I Q 0.102 Neutral MLH1 P40692 I637R 637 I R 0.284 Neutral MLH1 P40692 I637S 637 I S 0.072 Neutral MLH1 P40692 I637T 637 I T 0.002 Neutral MLH1 P40692 I637V 637 I V 0 Neutral MLH1 P40692 I637W 637 I W 0.408 Neutral MLH1 P40692 I637Y 637 I Y 0.362 Neutral MLH1 P40692 G638A 638 G A 0.046 Neutral MLH1 P40692 G638C 638 G C 0.462 Neutral MLH1 P40692 G638D 638 G D 0.684 Pathogenic MLH1 P40692 G638E 638 G E 0.764 Pathogenic MLH1 P40692 G638F 638 G F 0.924 Pathogenic MLH1 P40692 G638H 638 G H 0.898 Pathogenic MLH1 P40692 G638I 638 G I 0.634 Pathogenic MLH1 P40692 G638K 638 G K 0.898 Pathogenic MLH1 P40692 G638L 638 G L 0.904 Pathogenic MLH1 P40692 G638M 638 G M 0.922 Pathogenic MLH1 P40692 G638N 638 G N 0.674 Pathogenic MLH1 P40692 G638P 638 G P 0.856 Pathogenic MLH1 P40692 G638Q 638 G Q 0.738 Pathogenic MLH1 P40692 G638R 638 G R 0.546 Pathogenic MLH1 P40692 G638S 638 G S 0.08 Neutral MLH1 P40692 G638T 638 G T 0.51 Pathogenic MLH1 P40692 G638V 638 G V 0.892 Pathogenic MLH1 P40692 G638W 638 G W 0.92 Pathogenic MLH1 P40692 G638Y 638 G Y 0.912 Pathogenic MLH1 P40692 L639A 639 L A 0.562 Pathogenic MLH1 P40692 L639C 639 L C 0.686 Pathogenic MLH1 P40692 L639D 639 L D 0.916 Pathogenic MLH1 P40692 L639E 639 L E 0.896 Pathogenic MLH1 P40692 L639F 639 L F 0.942 Pathogenic MLH1 P40692 L639G 639 L G 0.814 Pathogenic MLH1 P40692 L639H 639 L H 0.786 Pathogenic MLH1 P40692 L639I 639 L I 0.12 Neutral MLH1 P40692 L639K 639 L K 0.732 Pathogenic MLH1 P40692 L639M 639 L M 0.452 Neutral MLH1 P40692 L639N 639 L N 0.788 Pathogenic MLH1 P40692 L639P 639 L P 0.986 Pathogenic MLH1 P40692 L639Q 639 L Q 0.614 Pathogenic MLH1 P40692 L639R 639 L R 0.718 Pathogenic MLH1 P40692 L639S 639 L S 0.608 Pathogenic MLH1 P40692 L639T 639 L T 0.582 Pathogenic MLH1 P40692 L639V 639 L V 0.094 Neutral MLH1 P40692 L639W 639 L W 0.91 Pathogenic MLH1 P40692 L639Y 639 L Y 0.87 Pathogenic MLH1 P40692 N64A 64 N A 0.734 Pathogenic MLH1 P40692 N64C 64 N C 0.8 Pathogenic MLH1 P40692 N64D 64 N D 0.232 Neutral MLH1 P40692 N64E 64 N E 0.738 Pathogenic MLH1 P40692 N64F 64 N F 0.966 Pathogenic MLH1 P40692 N64G 64 N G 0.888 Pathogenic MLH1 P40692 N64H 64 N H 0.944 Pathogenic MLH1 P40692 N64I 64 N I 0.842 Pathogenic MLH1 P40692 N64K 64 N K 0.984 Pathogenic MLH1 P40692 N64L 64 N L 0.966 Pathogenic MLH1 P40692 N64M 64 N M 0.972 Pathogenic MLH1 P40692 N64P 64 N P 0.768 Pathogenic MLH1 P40692 N64Q 64 N Q 0.964 Pathogenic MLH1 P40692 N64R 64 N R 0.698 Pathogenic MLH1 P40692 N64S 64 N S 0.94 Pathogenic 4 MLH1 P40692 N64T 64 N T 0.682 Pathogenic MLH1 P40692 N64V 64 N V 0.99 Pathogenic MLH1 P40692 N64W 64 N W 0.978 Pathogenic MLH1 P40692 N64Y 64 N Y 0.974 Pathogenic MLH1 P40692 P640A 640 P A 0.824 Pathogenic MLH1 P40692 P640C 640 P C 0.912 Pathogenic MLH1 P40692 P640D 640 P D 0.858 Pathogenic MLH1 P40692 P640E 640 P E 0.586 Pathogenic MLH1 P40692 P640F 640 P F 0.996 Pathogenic MLH1 P40692 P640G 640 P G 0.652 Pathogenic MLH1 P40692 P640H 640 P H 0.978 Pathogenic MLH1 P40692 P640I 640 P I 0.936 Pathogenic MLH1 P40692 P640K 640 P K 0.95 Pathogenic MLH1 P40692 P640L 640 P L 0.326 Neutral MLH1 P40692 P640M 640 P M 0.956 Pathogenic MLH1 P40692 P640N 640 P N 0.42 Neutral MLH1 P40692 P640Q 640 P Q 0.846 Pathogenic MLH1 P40692 P640R 640 P R 0.98 Pathogenic MLH1 P40692 P640S 640 P S 0.332 Neutral MLH1 P40692 P640T 640 P T 0.372 Neutral MLH1 P40692 P640V 640 P V 0.85 Pathogenic MLH1 P40692 P640W 640 P W 0.934 Pathogenic MLH1 P40692 P640Y 640 P Y 0.932 Pathogenic MLH1 P40692 L641A 641 L A 0.04 Neutral MLH1 P40692 L641C 641 L C 0.176 Neutral MLH1 P40692 L641D 641 L D 0.61 Pathogenic MLH1 P40692 L641E 641 L E 0.446 Neutral MLH1 P40692 L641F 641 L F 0.77 Pathogenic MLH1 P40692 L641G 641 L G 0.178 Neutral MLH1 P40692 L641H 641 L H 0.348 Neutral MLH1 P40692 L641I 641 L I 0.056 Neutral MLH1 P40692 L641K 641 L K 0.456 Neutral MLH1 P40692 L641M 641 L M 0.016 Neutral MLH1 P40692 L641N 641 L N 0.516 Pathogenic MLH1 P40692 L641P 641 L P 0.908 Pathogenic MLH1 P40692 L641Q 641 L Q 0.036 Neutral MLH1 P40692 L641R 641 L R 0.614 Pathogenic MLH1 P40692 L641S 641 L S 0.046 Neutral MLH1 P40692 L641T 641 L T 0.434 Neutral MLH1 P40692 L641V 641 L V 0.004 Neutral MLH1 P40692 L641W 641 L W 0.866 Pathogenic MLH1 P40692 L641Y 641 L Y 0.666 Pathogenic MLH1 P40692 L642A 642 L A 0.57 Pathogenic MLH1 P40692 L642C 642 L C 0.698 Pathogenic MLH1 P40692 L642D 642 L D 0.91 Pathogenic MLH1 P40692 L642E 642 L E 0.888 Pathogenic MLH1 P40692 L642F 642 L F 0.96 Pathogenic MLH1 P40692 L642G 642 L G 0.806 Pathogenic MLH1 P40692 L642H 642 L H 0.806 Pathogenic MLH1 P40692 L642I 642 L I 0.14 Neutral MLH1 P40692 L642K 642 L K 0.746 Pathogenic MLH1 P40692 L642M 642 L M 0.18 Neutral MLH1 P40692 L642N 642 L N 0.78 Pathogenic MLH1 P40692 L642P 642 L P 0.994 Pathogenic MLH1 P40692 L642Q 642 L Q 0.624 Pathogenic MLH1 P40692 L642R 642 L R 0.712 Pathogenic MLH1 P40692 L642S 642 L S 0.616 Pathogenic MLH1 P40692 L642T 642 L T 0.594 Pathogenic MLH1 P40692 L642V 642 L V 0.084 Neutral MLH1 P40692 L642W 642 L W 0.928 Pathogenic MLH1 P40692 L642Y 642 L Y 0.736 Pathogenic MLH1 P40692 I643A 643 I A 0.15 Neutral MLH1 P40692 I643C 643 I C 0.434 Neutral MLH1 P40692 I643D 643 I D 0.612 Pathogenic MLH1 P40692 I643E 643 I E 0.6 Pathogenic MLH1 P40692 I643F 643 I F 0.672 Pathogenic MLH1 P40692 I643G 643 I G 0.588 Pathogenic MLH1 P40692 I643H 643 I H 0.266 Neutral MLH1 P40692 I643K 643 I K 0.598 Pathogenic MLH1 P40692 I643L 643 I L 0.138 Neutral MLH1 P40692 I643M 643 I M 0.038 Neutral MLH1 P40692 I643N 643 I N 0.656 Pathogenic MLH1 P40692 I643P 643 I P 0.716 Pathogenic MLH1 P40692 I643Q 643 I Q 0.636 Pathogenic MLH1 P40692 I643R 643 I R 0.814 Pathogenic MLH1 P40692 I643S 643 I S 0.09 Neutral MLH1 P40692 I643T 643 I T 0.282 Neutral MLH1 P40692 I643V 643 I V 0.006 Neutral MLH1 P40692 I643W 643 I W 0.79 Pathogenic MLH1 P40692 I643Y 643 I Y 0.85 Pathogenic MLH1 P40692 D644A 644 D A 0.22 Neutral MLH1 P40692 D644C 644 D C 0.672 Pathogenic MLH1 P40692 D644E 644 D E 0.016 Neutral MLH1 P40692 D644F 644 D F 0.87 Pathogenic MLH1 P40692 D644G 644 D G 0.094 Neutral MLH1 P40692 D644H 644 D H 0.362 Neutral MLH1 P40692 D644I 644 D I 0.836 Pathogenic MLH1 P40692 D644K 644 D K 0.064 Neutral MLH1 P40692 D644L 644 D L 0.826 Pathogenic MLH1 P40692 D644M 644 D M 0.742 Pathogenic MLH1 P40692 D644N 644 D N 0.132 Neutral MLH1 P40692 D644P 644 D P 0.104 Neutral MLH1 P40692 D644Q 644 D Q 0.072 Neutral MLH1 P40692 D644R 644 D R 0.434 Neutral MLH1 P40692 D644S 644 D S 0.256 Neutral MLH1 P40692 D644T 644 D T 0.558 Pathogenic MLH1 P40692 D644V 644 D V 0.3 Neutral MLH1 P40692 D644W 644 D W 0.936 Pathogenic MLH1 P40692 D644Y 644 D Y 0.938 Pathogenic MLH1 P40692 N645A 645 N A 0.29 Neutral MLH1 P40692 N645C 645 N C 0.552 Pathogenic MLH1 P40692 N645D 645 N D 0.038 Neutral MLH1 P40692 N645E 645 N E 0.062 Neutral MLH1 P40692 N645F 645 N F 0.778 Pathogenic MLH1 P40692 N645G 645 N G 0.074 Neutral MLH1 P40692 N645H 645 N H 0.166 Neutral MLH1 P40692 N645I 645 N I 0.728 Pathogenic MLH1 P40692 N645K 645 N K 0.07 Neutral MLH1 P40692 N645L 645 N L 0.716 Pathogenic MLH1 P40692 N645M 645 N M 0.672 Pathogenic MLH1 P40692 N645P 645 N P 0.634 Pathogenic MLH1 P40692 N645Q 645 N Q 0.048 Neutral MLH1 P40692 N645R 645 N R 0.526 Pathogenic MLH1 P40692 N645S 645 N S 0.062 Neutral MLH1 P40692 N645T 645 N T 0.55 Pathogenic MLH1 P40692 N645V 645 N V 0.754 Pathogenic MLH1 P40692 N645W 645 N W 0.882 Pathogenic MLH1 P40692 N645Y 645 N Y 0.848 Pathogenic MLH1 P40692 Y646A 646 Y A 0.148 Neutral MLH1 P40692 Y646C 646 Y C 0.54 Pathogenic MLH1 P40692 Y646D 646 Y D 0.796 Pathogenic MLH1 P40692 Y646E 646 Y E 0.732 Pathogenic MLH1 P40692 Y646F 646 Y F 0.09 Neutral MLH1 P40692 Y646G 646 Y G 0.24 Neutral MLH1 P40692 Y646H 646 Y H 0.1 Neutral MLH1 P40692 Y646I 646 Y I 0.182 Neutral MLH1 P40692 Y646K 646 Y K 0.82 Pathogenic MLH1 P40692 Y646L 646 Y L 0.142 Neutral MLH1 P40692 Y646M 646 Y M 0.596 Pathogenic MLH1 P40692 Y646N 646 Y N 0.62 Pathogenic MLH1 P40692 Y646P 646 Y P 0.68 Pathogenic MLH1 P40692 Y646Q 646 Y Q 0.544 Pathogenic MLH1 P40692 Y646R 646 Y R 0.766 Pathogenic MLH1 P40692 Y646S 646 Y S 0.384 Neutral MLH1 P40692 Y646T 646 Y T 0.272 Neutral MLH1 P40692 Y646V 646 Y V 0.146 Neutral MLH1 P40692 Y646W 646 Y W 0.768 Pathogenic MLH1 P40692 V647A 647 V A 0.02 Neutral MLH1 P40692 V647C 647 V C 0.122 Neutral MLH1 P40692 V647D 647 V D 0.12 Neutral MLH1 P40692 V647E 647 V E 0.066 Neutral MLH1 P40692 V647F 647 V F 0.318 Neutral MLH1 P40692 V647G 647 V G 0.304 Neutral MLH1 P40692 V647H 647 V H 0.162 Neutral MLH1 P40692 V647I 647 V I 0.018 Neutral MLH1 P40692 V647K 647 V K 0.088 Neutral MLH1 P40692 V647L 647 V L 0.004 Neutral MLH1 P40692 V647M 647 V M 0.028 Neutral MLH1 P40692 V647N 647 V N 0.052 Neutral MLH1 P40692 V647P 647 V P 0.376 Neutral MLH1 P40692 V647Q 647 V Q 0.074 Neutral MLH1 P40692 V647R 647 V R 0.544 Pathogenic MLH1 P40692 V647S 647 V S 0.018 Neutral MLH1 P40692 V647T 647 V T 0.01 Neutral MLH1 P40692 V647W 647 V W 0.608 Pathogenic MLH1 P40692 V647Y 647 V Y 0.536 Pathogenic MLH1 P40692 P648A 648 P A 0.824 Pathogenic MLH1 P40692 P648C 648 P C 0.912 Pathogenic MLH1 P40692 P648D 648 P D 0.858 Pathogenic MLH1 P40692 P648E 648 P E 0.956 Pathogenic MLH1 P40692 P648F 648 P F 0.996 Pathogenic MLH1 P40692 P648G 648 P G 0.652 Pathogenic MLH1 P40692 P648H 648 P H 0.978 Pathogenic MLH1 P40692 P648I 648 P I 0.936 Pathogenic MLH1 P40692 P648K 648 P K 0.95 Pathogenic MLH1 P40692 P648L 648 P L 0.996 Pathogenic 5 MLH1 P40692 P648M 648 P M 0.956 Pathogenic MLH1 P40692 P648N 648 P N 0.752 Pathogenic MLH1 P40692 P648Q 648 P Q 0.846 Pathogenic MLH1 P40692 P648R 648 P R 0.98 Pathogenic MLH1 P40692 P648S 648 P S 0.332 Neutral 5 MLH1 P40692 P648T 648 P T 0.372 Neutral MLH1 P40692 P648V 648 P V 0.85 Pathogenic MLH1 P40692 P648W 648 P W 0.934 Pathogenic MLH1 P40692 P648Y 648 P Y 0.932 Pathogenic MLH1 P40692 P649A 649 P A 0.096 Neutral MLH1 P40692 P649C 649 P C 0.088 Neutral MLH1 P40692 P649D 649 P D 0.054 Neutral MLH1 P40692 P649E 649 P E 0.13 Neutral MLH1 P40692 P649F 649 P F 0.656 Pathogenic MLH1 P40692 P649G 649 P G 0.284 Neutral MLH1 P40692 P649H 649 P H 0.736 Pathogenic MLH1 P40692 P649I 649 P I 0.106 Neutral MLH1 P40692 P649K 649 P K 0.584 Pathogenic MLH1 P40692 P649L 649 P L 0.112 Neutral MLH1 P40692 P649M 649 P M 0.626 Pathogenic MLH1 P40692 P649N 649 P N 0.05 Neutral MLH1 P40692 P649Q 649 P Q 0.174 Neutral MLH1 P40692 P649R 649 P R 0.768 Pathogenic MLH1 P40692 P649S 649 P S 0.056 Neutral MLH1 P40692 P649T 649 P T 0.44 Neutral MLH1 P40692 P649V 649 P V 0.116 Neutral MLH1 P40692 P649W 649 P W 0.804 Pathogenic MLH1 P40692 P649Y 649 P Y 0.502 Pathogenic MLH1 P40692 G65A 65 G A 0.646 Pathogenic MLH1 P40692 G65C 65 G C 0.942 Pathogenic MLH1 P40692 G65D 65 G D 0.998 Pathogenic 4 MLH1 P40692 G65E 65 G E 0.982 Pathogenic MLH1 P40692 G65F 65 G F 0.986 Pathogenic MLH1 P40692 G65H 65 G H 0.99 Pathogenic MLH1 P40692 G65I 65 G I 0.976 Pathogenic MLH1 P40692 G65K 65 G K 0.99 Pathogenic MLH1 P40692 G65L 65 G L 0.986 Pathogenic MLH1 P40692 G65M 65 G M 0.996 Pathogenic MLH1 P40692 G65N 65 G N 0.986 Pathogenic MLH1 P40692 G65P 65 G P 0.97 Pathogenic MLH1 P40692 G65Q 65 G Q 0.736 Pathogenic MLH1 P40692 G65R 65 G R 1 Pathogenic MLH1 P40692 G65S 65 G S 0.904 Pathogenic MLH1 P40692 G65T 65 G T 0.866 Pathogenic MLH1 P40692 G65V 65 G V 0.988 Pathogenic MLH1 P40692 G65W 65 G W 0.982 Pathogenic MLH1 P40692 G65Y 65 G Y 0.964 Pathogenic MLH1 P40692 L650A 650 L A 0.15 Neutral MLH1 P40692 L650C 650 L C 0.326 Neutral MLH1 P40692 L650D 650 L D 0.61 Pathogenic MLH1 P40692 L650E 650 L E 0.068 Neutral MLH1 P40692 L650F 650 L F 0.298 Neutral MLH1 P40692 L650G 650 L G 0.534 Pathogenic MLH1 P40692 L650H 650 L H 0.162 Neutral MLH1 P40692 L650I 650 L I 0.038 Neutral MLH1 P40692 L650K 650 L K 0.456 Neutral MLH1 P40692 L650M 650 L M 0.022 Neutral MLH1 P40692 L650N 650 L N 0.564 Pathogenic MLH1 P40692 L650P 650 L P 0.21 Neutral MLH1 P40692 L650Q 650 L Q 0.302 Neutral MLH1 P40692 L650R 650 L R 0.614 Pathogenic MLH1 P40692 L650S 650 L S 0.448 Neutral MLH1 P40692 L650T 650 L T 0.222 Neutral MLH1 P40692 L650V 650 L V 0.01 Neutral MLH1 P40692 L650W 650 L W 0.706 Pathogenic MLH1 P40692 L650Y 650 L Y 0.758 Pathogenic MLH1 P40692 E651A 651 E A 0.158 Neutral MLH1 P40692 E651C 651 E C 0.308 Neutral MLH1 P40692 E651D 651 E D 0.026 Neutral MLH1 P40692 E651F 651 E F 0.688 Pathogenic MLH1 P40692 E651G 651 E G 0.044 Neutral MLH1 P40692 E651H 651 E H 0.052 Neutral MLH1 P40692 E651I 651 E I 0.744 Pathogenic MLH1 P40692 E651K 651 E K 0.564 Pathogenic MLH1 P40692 E651L 651 E L 0.11 Neutral MLH1 P40692 E651M 651 E M 0.548 Pathogenic MLH1 P40692 E651N 651 E N 0.028 Neutral MLH1 P40692 E651P 651 E P 0.748 Pathogenic MLH1 P40692 E651Q 651 E Q 0.238 Neutral MLH1 P40692 E651R 651 E R 0.118 Neutral MLH1 P40692 E651S 651 E S 0.066 Neutral MLH1 P40692 E651T 651 E T 0.076 Neutral MLH1 P40692 E651V 651 E V 0.082 Neutral MLH1 P40692 E651W 651 E W 0.868 Pathogenic MLH1 P40692 E651Y 651 E Y 0.772 Pathogenic MLH1 P40692 G652A 652 G A 0.072 Neutral MLH1 P40692 G652C 652 G C 0.724 Pathogenic MLH1 P40692 G652D 652 G D 0.546 Pathogenic MLH1 P40692 G652E 652 G E 0.518 Pathogenic MLH1 P40692 G652F 652 G F 0.67 Pathogenic MLH1 P40692 G652H 652 G H 0.582 Pathogenic MLH1 P40692 G652I 652 G I 0.928 Pathogenic MLH1 P40692 G652K 652 G K 0.564 Pathogenic MLH1 P40692 G652L 652 G L 0.638 Pathogenic MLH1 P40692 G652M 652 G M 0.952 Pathogenic MLH1 P40692 G652N 652 G N 0.424 Neutral MLH1 P40692 G652P 652 G P 0.914 Pathogenic MLH1 P40692 G652Q 652 G Q 0.498 Neutral MLH1 P40692 G652R 652 G R 0.576 Pathogenic MLH1 P40692 G652S 652 G S 0.086 Neutral MLH1 P40692 G652T 652 G T 0.828 Pathogenic MLH1 P40692 G652V 652 G V 0.936 Pathogenic MLH1 P40692 G652W 652 G W 0.946 Pathogenic MLH1 P40692 G652Y 652 G Y 0.652 Pathogenic MLH1 P40692 L653A 653 L A 0.566 Pathogenic MLH1 P40692 L653C 653 L C 0.692 Pathogenic MLH1 P40692 L653D 653 L D 0.886 Pathogenic MLH1 P40692 L653E 653 L E 0.872 Pathogenic MLH1 P40692 L653F 653 L F 0.79 Pathogenic MLH1 P40692 L653G 653 L G 0.788 Pathogenic MLH1 P40692 L653H 653 L H 0.374 Neutral MLH1 P40692 L653I 653 L I 0.206 Neutral MLH1 P40692 L653K 653 L K 0.742 Pathogenic MLH1 P40692 L653M 653 L M 0.742 Pathogenic MLH1 P40692 L653N 653 L N 0.752 Pathogenic MLH1 P40692 L653P 653 L P 0.986 Pathogenic MLH1 P40692 L653Q 653 L Q 0.624 Pathogenic MLH1 P40692 L653R 653 L R 0.99 Pathogenic MLH1 P40692 L653S 653 L S 0.342 Neutral MLH1 P40692 L653T 653 L T 0.578 Pathogenic MLH1 P40692 L653V 653 L V 0.086 Neutral MLH1 P40692 L653W 653 L W 0.94 Pathogenic MLH1 P40692 L653Y 653 L Y 0.906 Pathogenic MLH1 P40692 P654A 654 P A 0.256 Neutral MLH1 P40692 P654C 654 P C 0.908 Pathogenic MLH1 P40692 P654D 654 P D 0.856 Pathogenic MLH1 P40692 P654E 654 P E 0.952 Pathogenic MLH1 P40692 P654F 654 P F 0.994 Pathogenic MLH1 P40692 P654G 654 P G 0.652 Pathogenic MLH1 P40692 P654H 654 P H 0.694 Pathogenic MLH1 P40692 P654I 654 P I 0.93 Pathogenic MLH1 P40692 P654K 654 P K 0.946 Pathogenic MLH1 P40692 P654L 654 P L 0.99 Pathogenic 5 MLH1 P40692 P654M 654 P M 0.952 Pathogenic MLH1 P40692 P654N 654 P N 0.75 Pathogenic MLH1 P40692 P654Q 654 P Q 0.842 Pathogenic MLH1 P40692 P654R 654 P R 0.976 Pathogenic MLH1 P40692 P654S 654 P S 0.2 Neutral MLH1 P40692 P654T 654 P T 0.7 Pathogenic MLH1 P40692 P654V 654 P V 0.846 Pathogenic MLH1 P40692 P654W 654 P W 0.93 Pathogenic MLH1 P40692 P654Y 654 P Y 0.926 Pathogenic MLH1 P40692 I655A 655 I A 0.07 Neutral MLH1 P40692 I655C 655 I C 0.142 Neutral MLH1 P40692 I655D 655 I D 0.246 Neutral MLH1 P40692 I655E 655 I E 0.04 Neutral MLH1 P40692 I655F 655 I F 0.094 Neutral MLH1 P40692 I655G 655 I G 0.21 Neutral MLH1 P40692 I655H 655 I H 0.016 Neutral MLH1 P40692 I655K 655 I K 0.238 Neutral MLH1 P40692 I655L 655 I L 0 Neutral MLH1 P40692 I655M 655 I M 0.028 Neutral MLH1 P40692 I655N 655 I N 0.108 Neutral MLH1 P40692 I655P 655 I P 0.248 Neutral MLH1 P40692 I655Q 655 I Q 0.106 Neutral MLH1 P40692 I655R 655 I R 0.344 Neutral MLH1 P40692 I655S 655 I S 0.096 Neutral MLH1 P40692 I655T 655 I T 0.008 Neutral MLH1 P40692 I655V 655 I V 0 Neutral 1 MLH1 P40692 I655W 655 I W 0.486 Neutral MLH1 P40692 I655Y 655 I Y 0.402 Neutral MLH1 P40692 F656A 656 F A 0.422 Neutral MLH1 P40692 F656C 656 F C 0.582 Pathogenic MLH1 P40692 F656D 656 F D 0.81 Pathogenic MLH1 P40692 F656E 656 F E 0.89 Pathogenic MLH1 P40692 F656G 656 F G 0.49 Neutral MLH1 P40692 F656H 656 F H 0.646 Pathogenic MLH1 P40692 F656I 656 F I 0.562 Pathogenic MLH1 P40692 F656K 656 F K 0.86 Pathogenic MLH1 P40692 F656L 656 F L 0.07 Neutral MLH1 P40692 F656M 656 F M 0.662 Pathogenic MLH1 P40692 F656N 656 F N 0.436 Neutral MLH1 P40692 F656P 656 F P 0.928 Pathogenic MLH1 P40692 F656Q 656 F Q 0.76 Pathogenic MLH1 P40692 F656R 656 F R 0.928 Pathogenic MLH1 P40692 F656S 656 F S 0.742 Pathogenic MLH1 P40692 F656T 656 F T 0.572 Pathogenic MLH1 P40692 F656V 656 F V 0.8 Pathogenic MLH1 P40692 F656W 656 F W 0.926 Pathogenic MLH1 P40692 F656Y 656 F Y 0.224 Neutral MLH1 P40692 I657A 657 I A 0.078 Neutral MLH1 P40692 I657C 657 I C 0.418 Neutral MLH1 P40692 I657D 657 I D 0.62 Pathogenic MLH1 P40692 I657E 657 I E 0.602 Pathogenic MLH1 P40692 I657F 657 I F 0.328 Neutral MLH1 P40692 I657G 657 I G 0.596 Pathogenic MLH1 P40692 I657H 657 I H 0.488 Neutral MLH1 P40692 I657K 657 I K 0.616 Pathogenic MLH1 P40692 I657L 657 I L 0.082 Neutral MLH1 P40692 I657M 657 I M 0.082 Neutral MLH1 P40692 I657N 657 I N 0.664 Pathogenic MLH1 P40692 I657P 657 I P 0.766 Pathogenic MLH1 P40692 I657Q 657 I Q 0.638 Pathogenic MLH1 P40692 I657R 657 I R 0.834 Pathogenic MLH1 P40692 I657S 657 I S 0.434 Neutral MLH1 P40692 I657T 657 I T 0.088 Neutral MLH1 P40692 I657V 657 I V 0.026 Neutral MLH1 P40692 I657W 657 I W 0.904 Pathogenic MLH1 P40692 I657Y 657 I Y 0.902 Pathogenic MLH1 P40692 L658A 658 L A 0.126 Neutral MLH1 P40692 L658C 658 L C 0.166 Neutral MLH1 P40692 L658D 658 L D 0.656 Pathogenic MLH1 P40692 L658E 658 L E 0.61 Pathogenic MLH1 P40692 L658F 658 L F 0.27 Neutral MLH1 P40692 L658G 658 L G 0.576 Pathogenic MLH1 P40692 L658H 658 L H 0.408 Neutral MLH1 P40692 L658I 658 L I 0.034 Neutral MLH1 P40692 L658K 658 L K 0.474 Neutral MLH1 P40692 L658M 658 L M 0.008 Neutral MLH1 P40692 L658N 658 L N 0.604 Pathogenic MLH1 P40692 L658P 658 L P 0.954 Pathogenic MLH1 P40692 L658Q 658 L Q 0.35 Neutral MLH1 P40692 L658R 658 L R 0.866 Pathogenic MLH1 P40692 L658S 658 L S 0.172 Neutral MLH1 P40692 L658T 658 L T 0.38 Neutral MLH1 P40692 L658V 658 L V 0.002 Neutral MLH1 P40692 L658W 658 L W 0.856 Pathogenic MLH1 P40692 L658Y 658 L Y 0.616 Pathogenic MLH1 P40692 R659A 659 R A 0.518 Pathogenic MLH1 P40692 R659C 659 R C 0.214 Neutral MLH1 P40692 R659D 659 R D 0.406 Neutral MLH1 P40692 R659E 659 R E 0.372 Neutral MLH1 P40692 R659F 659 R F 0.972 Pathogenic MLH1 P40692 R659G 659 R G 0.414 Neutral MLH1 P40692 R659H 659 R H 0.234 Neutral MLH1 P40692 R659I 659 R I 0.974 Pathogenic MLH1 P40692 R659K 659 R K 0.386 Neutral MLH1 P40692 R659L 659 R L 0.984 Pathogenic MLH1 P40692 R659M 659 R M 0.8 Pathogenic MLH1 P40692 R659N 659 R N 0.138 Neutral MLH1 P40692 R659P 659 R P 0.984 Pathogenic 5 MLH1 P40692 R659Q 659 R Q 0.184 Neutral MLH1 P40692 R659S 659 R S 0.168 Neutral MLH1 P40692 R659T 659 R T 0.384 Neutral MLH1 P40692 R659V 659 R V 0.972 Pathogenic MLH1 P40692 R659W 659 R W 0.892 Pathogenic MLH1 P40692 R659Y 659 R Y 0.972 Pathogenic MLH1 P40692 T66A 66 T A 0.422 Neutral MLH1 P40692 T66C 66 T C 0.088 Neutral MLH1 P40692 T66D 66 T D 0.51 Pathogenic MLH1 P40692 T66E 66 T E 0.41 Neutral MLH1 P40692 T66F 66 T F 0.734 Pathogenic MLH1 P40692 T66G 66 T G 0.114 Neutral MLH1 P40692 T66H 66 T H 0.216 Neutral MLH1 P40692 T66I 66 T I 0.538 Pathogenic MLH1 P40692 T66K 66 T K 0.33 Neutral MLH1 P40692 T66L 66 T L 0.544 Pathogenic MLH1 P40692 T66M 66 T M 0.676 Pathogenic MLH1 P40692 T66N 66 T N 0.128 Neutral MLH1 P40692 T66P 66 T P 0.636 Pathogenic MLH1 P40692 T66Q 66 T Q 0.196 Neutral MLH1 P40692 T66R 66 T R 0.518 Pathogenic MLH1 P40692 T66S 66 T S 0.034 Neutral MLH1 P40692 T66V 66 T V 0.754 Pathogenic MLH1 P40692 T66W 66 T W 0.94 Pathogenic MLH1 P40692 T66Y 66 T Y 0.934 Pathogenic MLH1 P40692 L660A 660 L A 0.568 Pathogenic MLH1 P40692 L660C 660 L C 0.684 Pathogenic MLH1 P40692 L660D 660 L D 0.87 Pathogenic MLH1 P40692 L660E 660 L E 0.856 Pathogenic MLH1 P40692 L660F 660 L F 0.792 Pathogenic MLH1 P40692 L660G 660 L G 0.784 Pathogenic MLH1 P40692 L660H 660 L H 0.814 Pathogenic MLH1 P40692 L660I 660 L I 0.228 Neutral MLH1 P40692 L660K 660 L K 0.728 Pathogenic MLH1 P40692 L660M 660 L M 0.194 Neutral MLH1 P40692 L660N 660 L N 0.736 Pathogenic MLH1 P40692 L660P 660 L P 0.69 Pathogenic MLH1 P40692 L660Q 660 L Q 0.614 Pathogenic MLH1 P40692 L660R 660 L R 0.978 Pathogenic MLH1 P40692 L660S 660 L S 0.334 Neutral MLH1 P40692 L660T 660 L T 0.326 Neutral MLH1 P40692 L660V 660 L V 0.296 Neutral MLH1 P40692 L660W 660 L W 0.936 Pathogenic MLH1 P40692 L660Y 660 L Y 0.9 Pathogenic MLH1 P40692 A661C 661 A C 0.37 Neutral MLH1 P40692 A661D 661 A D 0.828 Pathogenic MLH1 P40692 A661E 661 A E 0.832 Pathogenic MLH1 P40692 A661F 661 A F 0.926 Pathogenic MLH1 P40692 A661G 661 A G 0.048 Neutral MLH1 P40692 A661H 661 A H 0.822 Pathogenic MLH1 P40692 A661I 661 A I 0.892 Pathogenic MLH1 P40692 A661K 661 A K 0.866 Pathogenic MLH1 P40692 A661L 661 A L 0.876 Pathogenic MLH1 P40692 A661M 661 A M 0.784 Pathogenic MLH1 P40692 A661N 661 A N 0.736 Pathogenic MLH1 P40692 A661P 661 A P 0.872 Pathogenic MLH1 P40692 A661Q 661 A Q 0.76 Pathogenic MLH1 P40692 A661R 661 A R 0.844 Pathogenic MLH1 P40692 A661S 661 A S 0.01 Neutral MLH1 P40692 A661T 661 A T 0.144 Neutral MLH1 P40692 A661V 661 A V 0.184 Neutral MLH1 P40692 A661W 661 A W 0.924 Pathogenic MLH1 P40692 A661Y 661 A Y 0.902 Pathogenic MLH1 P40692 T662A 662 T A 0.108 Neutral MLH1 P40692 T662C 662 T C 0.112 Neutral MLH1 P40692 T662D 662 T D 0.384 Neutral MLH1 P40692 T662E 662 T E 0.682 Pathogenic MLH1 P40692 T662F 662 T F 0.78 Pathogenic MLH1 P40692 T662G 662 T G 0.124 Neutral MLH1 P40692 T662H 662 T H 0.458 Neutral MLH1 P40692 T662I 662 T I 0.31 Neutral MLH1 P40692 T662K 662 T K 0.282 Neutral MLH1 P40692 T662L 662 T L 0.62 Pathogenic MLH1 P40692 T662M 662 T M 0.734 Pathogenic MLH1 P40692 T662N 662 T N 0.016 Neutral MLH1 P40692 T662P 662 T P 0.06 Neutral 1 MLH1 P40692 T662Q 662 T Q 0.176 Neutral MLH1 P40692 T662R 662 T R 0.86 Pathogenic MLH1 P40692 T662S 662 T S 0.01 Neutral MLH1 P40692 T662V 662 T V 0.17 Neutral MLH1 P40692 T662W 662 T W 0.946 Pathogenic MLH1 P40692 T662Y 662 T Y 0.9 Pathogenic MLH1 P40692 E663A 663 E A 0.672 Pathogenic 4 MLH1 P40692 E663C 663 E C 0.424 Neutral MLH1 P40692 E663D 663 E D 0.036 Neutral 1 MLH1 P40692 E663F 663 E F 0.81 Pathogenic MLH1 P40692 E663G 663 E G 0.152 Neutral 1 MLH1 P40692 E663H 663 E H 0.07 Neutral MLH1 P40692 E663I 663 E I 0.642 Pathogenic MLH1 P40692 E663K 663 E K 0.068 Neutral MLH1 P40692 E663L 663 E L 0.526 Pathogenic MLH1 P40692 E663M 663 E M 0.684 Pathogenic MLH1 P40692 E663N 663 E N 0.046 Neutral MLH1 P40692 E663P 663 E P 0.852 Pathogenic MLH1 P40692 E663Q 663 E Q 0.032 Neutral MLH1 P40692 E663R 663 E R 0.136 Neutral MLH1 P40692 E663S 663 E S 0.482 Neutral MLH1 P40692 E663T 663 E T 0.566 Pathogenic MLH1 P40692 E663V 663 E V 0.786 Pathogenic MLH1 P40692 E663W 663 E W 0.94 Pathogenic MLH1 P40692 E663Y 663 E Y 0.368 Neutral MLH1 P40692 V664A 664 V A 0.026 Neutral MLH1 P40692 V664C 664 V C 0.106 Neutral MLH1 P40692 V664D 664 V D 0.414 Neutral MLH1 P40692 V664E 664 V E 0.702 Pathogenic MLH1 P40692 V664F 664 V F 0.764 Pathogenic MLH1 P40692 V664G 664 V G 0.614 Pathogenic MLH1 P40692 V664H 664 V H 0.56 Pathogenic MLH1 P40692 V664I 664 V I 0.08 Neutral MLH1 P40692 V664K 664 V K 0.594 Pathogenic MLH1 P40692 V664L 664 V L 0.226 Neutral MLH1 P40692 V664M 664 V M 0.52 Pathogenic MLH1 P40692 V664N 664 V N 0.47 Neutral MLH1 P40692 V664P 664 V P 0.822 Pathogenic MLH1 P40692 V664Q 664 V Q 0.722 Pathogenic MLH1 P40692 V664R 664 V R 0.824 Pathogenic MLH1 P40692 V664S 664 V S 0.462 Neutral MLH1 P40692 V664T 664 V T 0.432 Neutral MLH1 P40692 V664W 664 V W 0.84 Pathogenic MLH1 P40692 V664Y 664 V Y 0.832 Pathogenic MLH1 P40692 N665A 665 N A 0.508 Pathogenic MLH1 P40692 N665C 665 N C 0.362 Neutral MLH1 P40692 N665D 665 N D 0.04 Neutral MLH1 P40692 N665E 665 N E 0.074 Neutral MLH1 P40692 N665F 665 N F 0.906 Pathogenic MLH1 P40692 N665G 665 N G 0.53 Pathogenic MLH1 P40692 N665H 665 N H 0.744 Pathogenic MLH1 P40692 N665I 665 N I 0.868 Pathogenic MLH1 P40692 N665K 665 N K 0.788 Pathogenic MLH1 P40692 N665L 665 N L 0.858 Pathogenic MLH1 P40692 N665M 665 N M 0.818 Pathogenic MLH1 P40692 N665P 665 N P 0.524 Pathogenic MLH1 P40692 N665Q 665 N Q 0.62 Pathogenic MLH1 P40692 N665R 665 N R 0.496 Neutral MLH1 P40692 N665S 665 N S 0.074 Neutral MLH1 P40692 N665T 665 N T 0.328 Neutral MLH1 P40692 N665V 665 N V 0.474 Neutral MLH1 P40692 N665W 665 N W 0.954 Pathogenic MLH1 P40692 N665Y 665 N Y 0.946 Pathogenic MLH1 P40692 W666A 666 W A 0.408 Neutral MLH1 P40692 W666C 666 W C 0.412 Neutral MLH1 P40692 W666D 666 W D 0.476 Neutral MLH1 P40692 W666E 666 W E 0.762 Pathogenic MLH1 P40692 W666F 666 W F 0.61 Pathogenic MLH1 P40692 W666G 666 W G 0.408 Neutral MLH1 P40692 W666H 666 W H 0.642 Pathogenic MLH1 P40692 W666I 666 W I 0.496 Neutral MLH1 P40692 W666K 666 W K 0.476 Neutral MLH1 P40692 W666L 666 W L 0.168 Neutral MLH1 P40692 W666M 666 W M 0.644 Pathogenic MLH1 P40692 W666N 666 W N 0.418 Neutral MLH1 P40692 W666P 666 W P 0.522 Pathogenic MLH1 P40692 W666Q 666 W Q 0.542 Pathogenic MLH1 P40692 W666R 666 W R 0.644 Pathogenic MLH1 P40692 W666S 666 W S 0.264 Neutral MLH1 P40692 W666T 666 W T 0.408 Neutral MLH1 P40692 W666V 666 W V 0.47 Neutral MLH1 P40692 W666Y 666 W Y 0.198 Neutral MLH1 P40692 D667A 667 D A 0.452 Neutral MLH1 P40692 D667C 667 D C 0.66 Pathogenic MLH1 P40692 D667E 667 D E 0.028 Neutral MLH1 P40692 D667F 667 D F 0.87 Pathogenic MLH1 P40692 D667G 667 D G 0.052 Neutral MLH1 P40692 D667H 667 D H 0.41 Neutral MLH1 P40692 D667I 667 D I 0.818 Pathogenic MLH1 P40692 D667K 667 D K 0.066 Neutral MLH1 P40692 D667L 667 D L 0.424 Neutral MLH1 P40692 D667M 667 D M 0.4 Neutral MLH1 P40692 D667N 667 D N 0.008 Neutral MLH1 P40692 D667P 667 D P 0.772 Pathogenic MLH1 P40692 D667Q 667 D Q 0.236 Neutral MLH1 P40692 D667R 667 D R 0.402 Neutral MLH1 P40692 D667S 667 D S 0.012 Neutral MLH1 P40692 D667T 667 D T 0.03 Neutral MLH1 P40692 D667V 667 D V 0.814 Pathogenic MLH1 P40692 D667W 667 D W 0.93 Pathogenic MLH1 P40692 D667Y 667 D Y 0.92 Pathogenic MLH1 P40692 E668A 668 E A 0.304 Neutral MLH1 P40692 E668C 668 E C 0.366 Neutral MLH1 P40692 E668D 668 E D 0.016 Neutral MLH1 P40692 E668F 668 E F 0.446 Neutral MLH1 P40692 E668G 668 E G 0.058 Neutral MLH1 P40692 E668H 668 E H 0.146 Neutral MLH1 P40692 E668I 668 E I 0.576 Pathogenic MLH1 P40692 E668K 668 E K 0.028 Neutral MLH1 P40692 E668L 668 E L 0.812 Pathogenic MLH1 P40692 E668M 668 E M 0.636 Pathogenic MLH1 P40692 E668N 668 E N 0.014 Neutral MLH1 P40692 E668P 668 E P 0.84 Pathogenic MLH1 P40692 E668Q 668 E Q 0.016 Neutral MLH1 P40692 E668R 668 E R 0.406 Neutral MLH1 P40692 E668S 668 E S 0.038 Neutral MLH1 P40692 E668T 668 E T 0.034 Neutral MLH1 P40692 E668V 668 E V 0.212 Neutral MLH1 P40692 E668W 668 E W 0.918 Pathogenic MLH1 P40692 E668Y 668 E Y 0.844 Pathogenic MLH1 P40692 E669A 669 E A 0.812 Pathogenic MLH1 P40692 E669C 669 E C 0.758 Pathogenic MLH1 P40692 E669D 669 E D 0.892 Pathogenic MLH1 P40692 E669F 669 E F 0.964 Pathogenic MLH1 P40692 E669G 669 E G 0.382 Neutral MLH1 P40692 E669H 669 E H 0.796 Pathogenic MLH1 P40692 E669I 669 E I 0.98 Pathogenic MLH1 P40692 E669K 669 E K 0.67 Pathogenic MLH1 P40692 E669L 669 E L 0.972 Pathogenic MLH1 P40692 E669M 669 E M 0.91 Pathogenic MLH1 P40692 E669N 669 E N 0.77 Pathogenic MLH1 P40692 E669P 669 E P 0.934 Pathogenic MLH1 P40692 E669Q 669 E Q 0.85 Pathogenic MLH1 P40692 E669R 669 E R 0.93 Pathogenic MLH1 P40692 E669S 669 E S 0.188 Neutral MLH1 P40692 E669T 669 E T 0.348 Neutral MLH1 P40692 E669V 669 E V 0.916 Pathogenic MLH1 P40692 E669W 669 E W 0.978 Pathogenic MLH1 P40692 E669Y 669 E Y 0.958 Pathogenic MLH1 P40692 G67A 67 G A 0.47 Neutral MLH1 P40692 G67C 67 G C 0.796 Pathogenic MLH1 P40692 G67D 67 G D 0.83 Pathogenic MLH1 P40692 G67E 67 G E 0.966 Pathogenic 5 MLH1 P40692 G67F 67 G F 0.974 Pathogenic MLH1 P40692 G67H 67 G H 0.974 Pathogenic MLH1 P40692 G67I 67 G I 0.96 Pathogenic MLH1 P40692 G67K 67 G K 0.978 Pathogenic MLH1 P40692 G67L 67 G L 0.966 Pathogenic MLH1 P40692 G67M 67 G M 0.986 Pathogenic MLH1 P40692 G67N 67 G N 0.802 Pathogenic MLH1 P40692 G67P 67 G P 0.932 Pathogenic MLH1 P40692 G67Q 67 G Q 0.868 Pathogenic MLH1 P40692 G67R 67 G R 0.924 Pathogenic 5 MLH1 P40692 G67S 67 G S 0.64 Pathogenic MLH1 P40692 G67T 67 G T 0.87 Pathogenic MLH1 P40692 G67V 67 G V 0.974 Pathogenic MLH1 P40692 G67W 67 G W 0.964 Pathogenic 4 MLH1 P40692 G67Y 67 G Y 0.958 Pathogenic MLH1 P40692 K670A 670 K A 0.072 Neutral MLH1 P40692 K670C 670 K C 0.196 Neutral MLH1 P40692 K670D 670 K D 0.308 Neutral MLH1 P40692 K670E 670 K E 0.016 Neutral MLH1 P40692 K670F 670 K F 0.844 Pathogenic MLH1 P40692 K670G 670 K G 0.31 Neutral MLH1 P40692 K670H 670 K H 0.392 Neutral MLH1 P40692 K670I 670 K I 0.892 Pathogenic MLH1 P40692 K670L 670 K L 0.138 Neutral MLH1 P40692 K670M 670 K M 0.134 Neutral MLH1 P40692 K670N 670 K N 0.154 Neutral MLH1 P40692 K670P 670 K P 0.716 Pathogenic MLH1 P40692 K670Q 670 K Q 0.024 Neutral MLH1 P40692 K670R 670 K R 0.038 Neutral MLH1 P40692 K670S 670 K S 0.428 Neutral MLH1 P40692 K670T 670 K T 0.036 Neutral MLH1 P40692 K670V 670 K V 0.394 Neutral MLH1 P40692 K670W 670 K W 0.98 Pathogenic MLH1 P40692 K670Y 670 K Y 0.932 Pathogenic MLH1 P40692 E671A 671 E A 0.164 Neutral MLH1 P40692 E671C 671 E C 0.37 Neutral MLH1 P40692 E671D 671 E D 0.022 Neutral MLH1 P40692 E671F 671 E F 0.792 Pathogenic MLH1 P40692 E671G 671 E G 0.032 Neutral MLH1 P40692 E671H 671 E H 0.518 Pathogenic MLH1 P40692 E671I 671 E I 0.838 Pathogenic MLH1 P40692 E671K 671 E K 0.028 Neutral MLH1 P40692 E671L 671 E L 0.11 Neutral MLH1 P40692 E671M 671 E M 0.654 Pathogenic MLH1 P40692 E671N 671 E N 0.026 Neutral MLH1 P40692 E671P 671 E P 0.098 Neutral MLH1 P40692 E671Q 671 E Q 0.02 Neutral MLH1 P40692 E671R 671 E R 0.136 Neutral MLH1 P40692 E671S 671 E S 0.05 Neutral MLH1 P40692 E671T 671 E T 0.058 Neutral MLH1 P40692 E671V 671 E V 0.206 Neutral MLH1 P40692 E671W 671 E W 0.902 Pathogenic MLH1 P40692 E671Y 671 E Y 0.824 Pathogenic MLH1 P40692 C672A 672 C A 0.73 Pathogenic MLH1 P40692 C672D 672 C D 0.946 Pathogenic MLH1 P40692 C672E 672 C E 0.844 Pathogenic MLH1 P40692 C672F 672 C F 0.966 Pathogenic MLH1 P40692 C672G 672 C G 0.37 Neutral MLH1 P40692 C672H 672 C H 0.804 Pathogenic MLH1 P40692 C672I 672 C I 0.952 Pathogenic MLH1 P40692 C672K 672 C K 0.726 Pathogenic MLH1 P40692 C672L 672 C L 0.956 Pathogenic MLH1 P40692 C672M 672 C M 0.712 Pathogenic MLH1 P40692 C672N 672 C N 0.362 Neutral MLH1 P40692 C672P 672 C P 0.97 Pathogenic MLH1 P40692 C672Q 672 C Q 0.608 Pathogenic MLH1 P40692 C672R 672 C R 1 Pathogenic MLH1 P40692 C672S 672 C S 0.506 Pathogenic MLH1 P40692 C672T 672 C T 0.674 Pathogenic MLH1 P40692 C672V 672 C V 0.68 Pathogenic MLH1 P40692 C672W 672 C W 0.976 Pathogenic MLH1 P40692 C672Y 672 C Y 0.962 Pathogenic MLH1 P40692 F673A 673 F A 0.418 Neutral MLH1 P40692 F673C 673 F C 0.578 Pathogenic MLH1 P40692 F673D 673 F D 0.768 Pathogenic MLH1 P40692 F673E 673 F E 0.852 Pathogenic MLH1 P40692 F673G 673 F G 0.478 Neutral MLH1 P40692 F673H 673 F H 0.632 Pathogenic MLH1 P40692 F673I 673 F I 0.148 Neutral MLH1 P40692 F673K 673 F K 0.834 Pathogenic MLH1 P40692 F673L 673 F L 0.082 Neutral MLH1 P40692 F673M 673 F M 0.656 Pathogenic MLH1 P40692 F673N 673 F N 0.426 Neutral MLH1 P40692 F673P 673 F P 0.488 Neutral MLH1 P40692 F673Q 673 F Q 0.72 Pathogenic MLH1 P40692 F673R 673 F R 0.906 Pathogenic MLH1 P40692 F673S 673 F S 0.412 Neutral MLH1 P40692 F673T 673 F T 0.576 Pathogenic MLH1 P40692 F673V 673 F V 0.418 Neutral MLH1 P40692 F673W 673 F W 0.944 Pathogenic MLH1 P40692 F673Y 673 F Y 0.71 Pathogenic MLH1 P40692 E674A 674 E A 0.188 Neutral MLH1 P40692 E674C 674 E C 0.398 Neutral MLH1 P40692 E674D 674 E D 0.016 Neutral MLH1 P40692 E674F 674 E F 0.784 Pathogenic MLH1 P40692 E674G 674 E G 0.02 Neutral MLH1 P40692 E674H 674 E H 0.032 Neutral MLH1 P40692 E674I 674 E I 0.852 Pathogenic MLH1 P40692 E674K 674 E K 0.036 Neutral MLH1 P40692 E674L 674 E L 0.46 Neutral MLH1 P40692 E674M 674 E M 0.64 Pathogenic MLH1 P40692 E674N 674 E N 0.016 Neutral MLH1 P40692 E674P 674 E P 0.846 Pathogenic MLH1 P40692 E674Q 674 E Q 0.008 Neutral MLH1 P40692 E674R 674 E R 0.072 Neutral MLH1 P40692 E674S 674 E S 0.034 Neutral MLH1 P40692 E674T 674 E T 0.572 Pathogenic MLH1 P40692 E674V 674 E V 0.798 Pathogenic MLH1 P40692 E674W 674 E W 0.92 Pathogenic MLH1 P40692 E674Y 674 E Y 0.846 Pathogenic MLH1 P40692 S675A 675 S A 0.138 Neutral MLH1 P40692 S675C 675 S C 0.244 Neutral MLH1 P40692 S675D 675 S D 0.078 Neutral MLH1 P40692 S675E 675 S E 0.458 Neutral MLH1 P40692 S675F 675 S F 0.884 Pathogenic MLH1 P40692 S675G 675 S G 0.016 Neutral MLH1 P40692 S675H 675 S H 0.8 Pathogenic MLH1 P40692 S675I 675 S I 0.6 Pathogenic MLH1 P40692 S675K 675 S K 0.736 Pathogenic MLH1 P40692 S675L 675 S L 0.612 Pathogenic MLH1 P40692 S675M 675 S M 0.976 Pathogenic MLH1 P40692 S675N 675 S N 0.066 Neutral MLH1 P40692 S675P 675 S P 0.604 Pathogenic MLH1 P40692 S675Q 675 S Q 0.584 Pathogenic MLH1 P40692 S675R 675 S R 0.81 Pathogenic MLH1 P40692 S675T 675 S T 0.104 Neutral MLH1 P40692 S675V 675 S V 0.786 Pathogenic MLH1 P40692 S675W 675 S W 0.952 Pathogenic MLH1 P40692 S675Y 675 S Y 0.932 Pathogenic MLH1 P40692 L676A 676 L A 0.284 Neutral MLH1 P40692 L676C 676 L C 0.358 Neutral MLH1 P40692 L676D 676 L D 0.646 Pathogenic MLH1 P40692 L676E 676 L E 0.598 Pathogenic MLH1 P40692 L676F 676 L F 0.396 Neutral MLH1 P40692 L676G 676 L G 0.486 Neutral MLH1 P40692 L676H 676 L H 0.376 Neutral MLH1 P40692 L676I 676 L I 0.044 Neutral MLH1 P40692 L676K 676 L K 0.474 Neutral MLH1 P40692 L676M 676 L M 0.46 Neutral MLH1 P40692 L676N 676 L N 0.51 Pathogenic MLH1 P40692 L676P 676 L P 0.952 Pathogenic MLH1 P40692 L676Q 676 L Q 0.324 Neutral MLH1 P40692 L676R 676 L R 0.862 Pathogenic MLH1 P40692 L676S 676 L S 0.408 Neutral MLH1 P40692 L676T 676 L T 0.39 Neutral MLH1 P40692 L676V 676 L V 0.004 Neutral MLH1 P40692 L676W 676 L W 0.866 Pathogenic MLH1 P40692 L676Y 676 L Y 0.874 Pathogenic MLH1 P40692 S677A 677 S A 0.078 Neutral MLH1 P40692 S677C 677 S C 0.07 Neutral MLH1 P40692 S677D 677 S D 0.434 Neutral MLH1 P40692 S677E 677 S E 0.594 Pathogenic MLH1 P40692 S677F 677 S F 0.67 Pathogenic MLH1 P40692 S677G 677 S G 0.276 Neutral MLH1 P40692 S677H 677 S H 0.744 Pathogenic MLH1 P40692 S677I 677 S I 0.466 Neutral MLH1 P40692 S677K 677 S K 0.678 Pathogenic MLH1 P40692 S677L 677 S L 0.164 Neutral MLH1 P40692 S677M 677 S M 0.562 Pathogenic MLH1 P40692 S677N 677 S N 0.286 Neutral MLH1 P40692 S677P 677 S P 0.558 Pathogenic MLH1 P40692 S677Q 677 S Q 0.612 Pathogenic MLH1 P40692 S677R 677 S R 0.75 Pathogenic MLH1 P40692 S677T 677 S T 0.568 Pathogenic MLH1 P40692 S677V 677 S V 0.124 Neutral MLH1 P40692 S677W 677 S W 0.918 Pathogenic MLH1 P40692 S677Y 677 S Y 0.902 Pathogenic MLH1 P40692 K678A 678 K A 0.086 Neutral MLH1 P40692 K678C 678 K C 0.206 Neutral MLH1 P40692 K678D 678 K D 0.32 Neutral MLH1 P40692 K678E 678 K E 0.076 Neutral MLH1 P40692 K678F 678 K F 0.844 Pathogenic MLH1 P40692 K678G 678 K G 0.294 Neutral MLH1 P40692 K678H 678 K H 0.028 Neutral MLH1 P40692 K678I 678 K I 0.116 Neutral MLH1 P40692 K678L 678 K L 0.668 Pathogenic MLH1 P40692 K678M 678 K M 0.654 Pathogenic MLH1 P40692 K678N 678 K N 0.362 Neutral MLH1 P40692 K678P 678 K P 0.832 Pathogenic MLH1 P40692 K678Q 678 K Q 0.034 Neutral MLH1 P40692 K678R 678 K R 0.078 Neutral MLH1 P40692 K678S 678 K S 0.402 Neutral MLH1 P40692 K678T 678 K T 0.032 Neutral MLH1 P40692 K678V 678 K V 0.362 Neutral MLH1 P40692 K678W 678 K W 0.91 Pathogenic MLH1 P40692 K678Y 678 K Y 0.926 Pathogenic MLH1 P40692 E679A 679 E A 0.252 Neutral MLH1 P40692 E679C 679 E C 0.63 Pathogenic MLH1 P40692 E679D 679 E D 0.724 Pathogenic MLH1 P40692 E679F 679 E F 0.93 Pathogenic MLH1 P40692 E679G 679 E G 0.128 Neutral MLH1 P40692 E679H 679 E H 0.718 Pathogenic MLH1 P40692 E679I 679 E I 0.788 Pathogenic MLH1 P40692 E679K 679 E K 0.866 Pathogenic MLH1 P40692 E679L 679 E L 0.728 Pathogenic MLH1 P40692 E679M 679 E M 0.822 Pathogenic MLH1 P40692 E679N 679 E N 0.614 Pathogenic MLH1 P40692 E679P 679 E P 0.908 Pathogenic MLH1 P40692 E679Q 679 E Q 0.074 Neutral MLH1 P40692 E679R 679 E R 0.512 Pathogenic MLH1 P40692 E679S 679 E S 0.148 Neutral MLH1 P40692 E679T 679 E T 0.384 Neutral MLH1 P40692 E679V 679 E V 0.328 Neutral MLH1 P40692 E679W 679 E W 0.978 Pathogenic MLH1 P40692 E679Y 679 E Y 0.954 Pathogenic MLH1 P40692 I68A 68 I A 0.308 Neutral MLH1 P40692 I68C 68 I C 0.38 Neutral MLH1 P40692 I68D 68 I D 0.568 Pathogenic MLH1 P40692 I68E 68 I E 0.55 Pathogenic MLH1 P40692 I68F 68 I F 0.63 Pathogenic MLH1 P40692 I68G 68 I G 0.648 Pathogenic MLH1 P40692 I68H 68 I H 0.384 Neutral MLH1 P40692 I68K 68 I K 0.584 Pathogenic MLH1 P40692 I68L 68 I L 0.54 Pathogenic MLH1 P40692 I68M 68 I M 0.408 Neutral MLH1 P40692 I68N 68 I N 0.728 Pathogenic 4 MLH1 P40692 I68P 68 I P 0.626 Pathogenic MLH1 P40692 I68Q 68 I Q 0.594 Pathogenic MLH1 P40692 I68R 68 I R 0.766 Pathogenic MLH1 P40692 I68S 68 I S 0.482 Neutral MLH1 P40692 I68T 68 I T 0.39 Neutral MLH1 P40692 I68V 68 I V 0.26 Neutral 1 MLH1 P40692 I68W 68 I W 0.812 Pathogenic MLH1 P40692 I68Y 68 I Y 0.804 Pathogenic MLH1 P40692 C680A 680 C A 0.082 Neutral MLH1 P40692 C680D 680 C D 0.518 Pathogenic MLH1 P40692 C680E 680 C E 0.582 Pathogenic MLH1 P40692 C680F 680 C F 0.664 Pathogenic MLH1 P40692 C680G 680 C G 0.472 Neutral MLH1 P40692 C680H 680 C H 0.752 Pathogenic MLH1 P40692 C680I 680 C I 0.126 Neutral MLH1 P40692 C680K 680 C K 0.68 Pathogenic MLH1 P40692 C680L 680 C L 0.124 Neutral MLH1 P40692 C680M 680 C M 0.624 Pathogenic MLH1 P40692 C680N 680 C N 0.286 Neutral MLH1 P40692 C680P 680 C P 0.858 Pathogenic MLH1 P40692 C680Q 680 C Q 0.502 Pathogenic MLH1 P40692 C680R 680 C R 0.912 Pathogenic 4 MLH1 P40692 C680S 680 C S 0.444 Neutral MLH1 P40692 C680T 680 C T 0.018 Neutral MLH1 P40692 C680V 680 C V 0.116 Neutral MLH1 P40692 C680W 680 C W 0.952 Pathogenic MLH1 P40692 C680Y 680 C Y 0.96 Pathogenic MLH1 P40692 A681C 681 A C 0.96 Pathogenic MLH1 P40692 A681D 681 A D 0.802 Pathogenic MLH1 P40692 A681E 681 A E 0.748 Pathogenic MLH1 P40692 A681F 681 A F 0.994 Pathogenic MLH1 P40692 A681G 681 A G 0.11 Neutral MLH1 P40692 A681H 681 A H 0.93 Pathogenic MLH1 P40692 A681I 681 A I 0.956 Pathogenic MLH1 P40692 A681K 681 A K 0.968 Pathogenic MLH1 P40692 A681L 681 A L 0.912 Pathogenic MLH1 P40692 A681M 681 A M 0.896 Pathogenic MLH1 P40692 A681N 681 A N 0.874 Pathogenic MLH1 P40692 A681P 681 A P 0.848 Pathogenic MLH1 P40692 A681Q 681 A Q 0.9 Pathogenic MLH1 P40692 A681R 681 A R 0.97 Pathogenic MLH1 P40692 A681S 681 A S 0.146 Neutral MLH1 P40692 A681T 681 A T 0.91 Pathogenic 5 MLH1 P40692 A681V 681 A V 0.614 Pathogenic MLH1 P40692 A681W 681 A W 0.994 Pathogenic MLH1 P40692 A681Y 681 A Y 0.962 Pathogenic MLH1 P40692 M682A 682 M A 0.05 Neutral MLH1 P40692 M682C 682 M C 0.07 Neutral MLH1 P40692 M682D 682 M D 0.238 Neutral MLH1 P40692 M682E 682 M E 0.02 Neutral MLH1 P40692 M682F 682 M F 0.04 Neutral MLH1 P40692 M682G 682 M G 0.178 Neutral MLH1 P40692 M682H 682 M H 0.014 Neutral MLH1 P40692 M682I 682 M I 0.012 Neutral MLH1 P40692 M682K 682 M K 0.024 Neutral MLH1 P40692 M682L 682 M L 0.014 Neutral MLH1 P40692 M682N 682 M N 0.26 Neutral MLH1 P40692 M682P 682 M P 0.414 Neutral MLH1 P40692 M682Q 682 M Q 0.032 Neutral MLH1 P40692 M682R 682 M R 0.054 Neutral MLH1 P40692 M682S 682 M S 0.012 Neutral MLH1 P40692 M682T 682 M T 0.008 Neutral MLH1 P40692 M682V 682 M V 0.024 Neutral MLH1 P40692 M682W 682 M W 0.668 Pathogenic MLH1 P40692 M682Y 682 M Y 0.146 Neutral MLH1 P40692 F683A 683 F A 0.054 Neutral MLH1 P40692 F683C 683 F C 0.128 Neutral MLH1 P40692 F683D 683 F D 0.246 Neutral MLH1 P40692 F683E 683 F E 0.054 Neutral MLH1 P40692 F683G 683 F G 0.078 Neutral MLH1 P40692 F683H 683 F H 0.102 Neutral MLH1 P40692 F683I 683 F I 0.008 Neutral MLH1 P40692 F683K 683 F K 0.252 Neutral MLH1 P40692 F683L 683 F L 0.004 Neutral MLH1 P40692 F683M 683 F M 0.088 Neutral MLH1 P40692 F683N 683 F N 0.26 Neutral MLH1 P40692 F683P 683 F P 0.04 Neutral MLH1 P40692 F683Q 683 F Q 0.14 Neutral MLH1 P40692 F683R 683 F R 0.24 Neutral MLH1 P40692 F683S 683 F S 0.096 Neutral MLH1 P40692 F683T 683 F T 0.018 Neutral MLH1 P40692 F683V 683 F V 0.01 Neutral MLH1 P40692 F683W 683 F W 0.49 Neutral MLH1 P40692 F683Y 683 F Y 0.156 Neutral MLH1 P40692 Y684A 684 Y A 0.064 Neutral MLH1 P40692 Y684C 684 Y C 0.186 Neutral MLH1 P40692 Y684D 684 Y D 0.042 Neutral MLH1 P40692 Y684E 684 Y E 0.042 Neutral MLH1 P40692 Y684F 684 Y F 0.01 Neutral MLH1 P40692 Y684G 684 Y G 0.118 Neutral MLH1 P40692 Y684H 684 Y H 0.104 Neutral MLH1 P40692 Y684I 684 Y I 0.156 Neutral MLH1 P40692 Y684K 684 Y K 0.142 Neutral MLH1 P40692 Y684L 684 Y L 0.014 Neutral MLH1 P40692 Y684M 684 Y M 0.138 Neutral MLH1 P40692 Y684N 684 Y N 0.08 Neutral MLH1 P40692 Y684P 684 Y P 0.048 Neutral MLH1 P40692 Y684Q 684 Y Q 0.072 Neutral MLH1 P40692 Y684R 684 Y R 0.138 Neutral MLH1 P40692 Y684S 684 Y S 0.116 Neutral MLH1 P40692 Y684T 684 Y T 0.18 Neutral MLH1 P40692 Y684V 684 Y V 0.038 Neutral MLH1 P40692 Y684W 684 Y W 0.086 Neutral MLH1 P40692 S685A 685 S A 0.014 Neutral MLH1 P40692 S685C 685 S C 0.154 Neutral MLH1 P40692 S685D 685 S D 0.012 Neutral MLH1 P40692 S685E 685 S E 0.31 Neutral MLH1 P40692 S685F 685 S F 0.65 Pathogenic MLH1 P40692 S685G 685 S G 0.014 Neutral MLH1 P40692 S685H 685 S H 0.56 Pathogenic MLH1 P40692 S685I 685 S I 0.284 Neutral MLH1 P40692 S685K 685 S K 0.378 Neutral MLH1 P40692 S685L 685 S L 0.1 Neutral MLH1 P40692 S685M 685 S M 0.456 Neutral MLH1 P40692 S685N 685 S N 0.12 Neutral MLH1 P40692 S685P 685 S P 0.076 Neutral MLH1 P40692 S685Q 685 S Q 0.342 Neutral MLH1 P40692 S685R 685 S R 0.406 Neutral MLH1 P40692 S685T 685 S T 0.038 Neutral MLH1 P40692 S685V 685 S V 0.07 Neutral MLH1 P40692 S685W 685 S W 0.86 Pathogenic MLH1 P40692 S685Y 685 S Y 0.824 Pathogenic MLH1 P40692 I686A 686 I A 0.012 Neutral MLH1 P40692 I686C 686 I C 0.078 Neutral MLH1 P40692 I686D 686 I D 0.042 Neutral MLH1 P40692 I686E 686 I E 0.04 Neutral MLH1 P40692 I686F 686 I F 0.094 Neutral MLH1 P40692 I686G 686 I G 0.21 Neutral MLH1 P40692 I686H 686 I H 0.15 Neutral MLH1 P40692 I686K 686 I K 0.052 Neutral MLH1 P40692 I686L 686 I L 0.002 Neutral MLH1 P40692 I686M 686 I M 0.026 Neutral MLH1 P40692 I686N 686 I N 0.108 Neutral MLH1 P40692 I686P 686 I P 0.07 Neutral MLH1 P40692 I686Q 686 I Q 0.106 Neutral MLH1 P40692 I686R 686 I R 0.346 Neutral MLH1 P40692 I686S 686 I S 0.078 Neutral MLH1 P40692 I686T 686 I T 0.008 Neutral MLH1 P40692 I686V 686 I V 0 Neutral MLH1 P40692 I686W 686 I W 0.542 Pathogenic MLH1 P40692 I686Y 686 I Y 0.5 Pathogenic MLH1 P40692 R687A 687 R A 0.08 Neutral MLH1 P40692 R687C 687 R C 0.236 Neutral MLH1 P40692 R687D 687 R D 0.028 Neutral MLH1 P40692 R687E 687 R E 0.034 Neutral MLH1 P40692 R687F 687 R F 0.198 Neutral MLH1 P40692 R687G 687 R G 0.012 Neutral MLH1 P40692 R687H 687 R H 0.012 Neutral MLH1 P40692 R687I 687 R I 0.114 Neutral MLH1 P40692 R687K 687 R K 0.012 Neutral MLH1 P40692 R687L 687 R L 0.038 Neutral MLH1 P40692 R687M 687 R M 0.018 Neutral MLH1 P40692 R687N 687 R N 0.014 Neutral MLH1 P40692 R687P 687 R P 0.056 Neutral MLH1 P40692 R687Q 687 R Q 0.016 Neutral MLH1 P40692 R687S 687 R S 0.024 Neutral MLH1 P40692 R687T 687 R T 0.026 Neutral MLH1 P40692 R687V 687 R V 0.046 Neutral MLH1 P40692 R687W 687 R W 0.69 Pathogenic 5 MLH1 P40692 R687Y 687 R Y 0.106 Neutral MLH1 P40692 K688A 688 K A 0.034 Neutral MLH1 P40692 K688C 688 K C 0.072 Neutral MLH1 P40692 K688D 688 K D 0.002 Neutral MLH1 P40692 K688E 688 K E 0.004 Neutral MLH1 P40692 K688F 688 K F 0.364 Neutral MLH1 P40692 K688G 688 K G 0.142 Neutral MLH1 P40692 K688H 688 K H 0.084 Neutral MLH1 P40692 K688I 688 K I 0.392 Neutral MLH1 P40692 K688L 688 K L 0.202 Neutral MLH1 P40692 K688M 688 K M 0.056 Neutral MLH1 P40692 K688N 688 K N 0.008 Neutral MLH1 P40692 K688P 688 K P 0.032 Neutral MLH1 P40692 K688Q 688 K Q 0.01 Neutral MLH1 P40692 K688R 688 K R 0.006 Neutral MLH1 P40692 K688S 688 K S 0.014 Neutral MLH1 P40692 K688T 688 K T 0.282 Neutral MLH1 P40692 K688V 688 K V 0.338 Neutral MLH1 P40692 K688W 688 K W 0.514 Pathogenic MLH1 P40692 K688Y 688 K Y 0.6 Pathogenic MLH1 P40692 Q689A 689 Q A 0.036 Neutral MLH1 P40692 Q689C 689 Q C 0.084 Neutral MLH1 P40692 Q689D 689 Q D 0 Neutral MLH1 P40692 Q689E 689 Q E 0.008 Neutral MLH1 P40692 Q689F 689 Q F 0.29 Neutral MLH1 P40692 Q689G 689 Q G 0.034 Neutral MLH1 P40692 Q689H 689 Q H 0.076 Neutral MLH1 P40692 Q689I 689 Q I 0.264 Neutral MLH1 P40692 Q689K 689 Q K 0.02 Neutral MLH1 P40692 Q689L 689 Q L 0.13 Neutral MLH1 P40692 Q689M 689 Q M 0.104 Neutral MLH1 P40692 Q689N 689 Q N 0.018 Neutral MLH1 P40692 Q689P 689 Q P 0.232 Neutral MLH1 P40692 Q689R 689 Q R 0.002 Neutral 1 MLH1 P40692 Q689S 689 Q S 0.034 Neutral MLH1 P40692 Q689T 689 Q T 0.002 Neutral MLH1 P40692 Q689V 689 Q V 0.018 Neutral MLH1 P40692 Q689W 689 Q W 0.49 Neutral MLH1 P40692 Q689Y 689 Q Y 0.424 Neutral MLH1 P40692 R69A 69 R A 0.152 Neutral MLH1 P40692 R69C 69 R C 0.274 Neutral MLH1 P40692 R69D 69 R D 0.116 Neutral MLH1 P40692 R69E 69 R E 0.282 Neutral MLH1 P40692 R69F 69 R F 0.472 Neutral MLH1 P40692 R69G 69 R G 0.098 Neutral MLH1 P40692 R69H 69 R H 0.118 Neutral MLH1 P40692 R69I 69 R I 0.5 Pathogenic MLH1 P40692 R69K 69 R K 0.014 Neutral MLH1 P40692 R69L 69 R L 0.434 Neutral MLH1 P40692 R69M 69 R M 0.296 Neutral MLH1 P40692 R69N 69 R N 0.324 Neutral MLH1 P40692 R69P 69 R P 0.432 Neutral MLH1 P40692 R69Q 69 R Q 0.014 Neutral MLH1 P40692 R69S 69 R S 0.03 Neutral MLH1 P40692 R69T 69 R T 0.216 Neutral MLH1 P40692 R69V 69 R V 0.4 Neutral MLH1 P40692 R69W 69 R W 0.622 Pathogenic MLH1 P40692 R69Y 69 R Y 0.466 Neutral MLH1 P40692 Y690A 690 Y A 0.046 Neutral MLH1 P40692 Y690C 690 Y C 0.132 Neutral MLH1 P40692 Y690D 690 Y D 0.112 Neutral MLH1 P40692 Y690E 690 Y E 0.032 Neutral MLH1 P40692 Y690F 690 Y F 0.01 Neutral MLH1 P40692 Y690G 690 Y G 0.098 Neutral MLH1 P40692 Y690H 690 Y H 0.054 Neutral MLH1 P40692 Y690I 690 Y I 0.016 Neutral MLH1 P40692 Y690K 690 Y K 0.04 Neutral MLH1 P40692 Y690L 690 Y L 0.012 Neutral MLH1 P40692 Y690M 690 Y M 0.008 Neutral MLH1 P40692 Y690N 690 Y N 0.144 Neutral MLH1 P40692 Y690P 690 Y P 0.032 Neutral MLH1 P40692 Y690Q 690 Y Q 0.064 Neutral MLH1 P40692 Y690R 690 Y R 0.086 Neutral MLH1 P40692 Y690S 690 Y S 0.096 Neutral MLH1 P40692 Y690T 690 Y T 0.126 Neutral MLH1 P40692 Y690V 690 Y V 0.014 Neutral MLH1 P40692 Y690W 690 Y W 0.048 Neutral MLH1 P40692 I691A 691 I A 0.006 Neutral MLH1 P40692 I691C 691 I C 0.066 Neutral MLH1 P40692 I691D 691 I D 0.028 Neutral MLH1 P40692 I691E 691 I E 0.028 Neutral MLH1 P40692 I691F 691 I F 0.206 Neutral MLH1 P40692 I691G 691 I G 0.23 Neutral MLH1 P40692 I691H 691 I H 0.046 Neutral MLH1 P40692 I691K 691 I K 0.042 Neutral MLH1 P40692 I691L 691 I L 0 Neutral MLH1 P40692 I691M 691 I M 0.018 Neutral MLH1 P40692 I691N 691 I N 0.096 Neutral MLH1 P40692 I691P 691 I P 0.062 Neutral MLH1 P40692 I691Q 691 I Q 0.096 Neutral MLH1 P40692 I691R 691 I R 0.26 Neutral MLH1 P40692 I691S 691 I S 0.072 Neutral MLH1 P40692 I691T 691 I T 0.002 Neutral MLH1 P40692 I691V 691 I V 0 Neutral MLH1 P40692 I691W 691 I W 0.294 Neutral MLH1 P40692 I691Y 691 I Y 0.298 Neutral MLH1 P40692 S692A 692 S A 0.01 Neutral MLH1 P40692 S692C 692 S C 0.022 Neutral MLH1 P40692 S692D 692 S D 0.002 Neutral MLH1 P40692 S692E 692 S E 0.138 Neutral MLH1 P40692 S692F 692 S F 0.25 Neutral MLH1 P40692 S692G 692 S G 0 Neutral MLH1 P40692 S692H 692 S H 0.17 Neutral MLH1 P40692 S692I 692 S I 0.194 Neutral MLH1 P40692 S692K 692 S K 0.15 Neutral MLH1 P40692 S692L 692 S L 0.026 Neutral MLH1 P40692 S692M 692 S M 0.252 Neutral MLH1 P40692 S692N 692 S N 0 Neutral MLH1 P40692 S692P 692 S P 0.062 Neutral MLH1 P40692 S692Q 692 S Q 0.186 Neutral MLH1 P40692 S692R 692 S R 0.152 Neutral MLH1 P40692 S692T 692 S T 0.02 Neutral MLH1 P40692 S692V 692 S V 0.032 Neutral MLH1 P40692 S692W 692 S W 0.49 Neutral MLH1 P40692 S692Y 692 S Y 0.434 Neutral MLH1 P40692 E693A 693 E A 0.118 Neutral MLH1 P40692 E693C 693 E C 0.07 Neutral MLH1 P40692 E693D 693 E D 0 Neutral MLH1 P40692 E693F 693 E F 0.35 Neutral MLH1 P40692 E693G 693 E G 0 Neutral MLH1 P40692 E693H 693 E H 0.096 Neutral MLH1 P40692 E693I 693 E I 0.276 Neutral MLH1 P40692 E693K 693 E K 0.026 Neutral MLH1 P40692 E693L 693 E L 0.054 Neutral MLH1 P40692 E693M 693 E M 0.178 Neutral MLH1 P40692 E693N 693 E N 0.002 Neutral MLH1 P40692 E693P 693 E P 0.076 Neutral MLH1 P40692 E693Q 693 E Q 0 Neutral MLH1 P40692 E693R 693 E R 0.038 Neutral MLH1 P40692 E693S 693 E S 0.014 Neutral MLH1 P40692 E693T 693 E T 0.022 Neutral MLH1 P40692 E693V 693 E V 0.148 Neutral MLH1 P40692 E693W 693 E W 0.532 Pathogenic MLH1 P40692 E693Y 693 E Y 0.426 Neutral MLH1 P40692 E694A 694 E A 0.066 Neutral MLH1 P40692 E694C 694 E C 0.068 Neutral MLH1 P40692 E694D 694 E D 0 Neutral MLH1 P40692 E694F 694 E F 0.164 Neutral MLH1 P40692 E694G 694 E G 0 Neutral MLH1 P40692 E694H 694 E H 0.04 Neutral MLH1 P40692 E694I 694 E I 0.322 Neutral MLH1 P40692 E694K 694 E K 0.002 Neutral MLH1 P40692 E694L 694 E L 0.038 Neutral MLH1 P40692 E694M 694 E M 0.166 Neutral MLH1 P40692 E694N 694 E N 0.002 Neutral MLH1 P40692 E694P 694 E P 0.064 Neutral MLH1 P40692 E694Q 694 E Q 0 Neutral MLH1 P40692 E694R 694 E R 0.016 Neutral MLH1 P40692 E694S 694 E S 0.014 Neutral MLH1 P40692 E694T 694 E T 0.006 Neutral MLH1 P40692 E694V 694 E V 0.25 Neutral MLH1 P40692 E694W 694 E W 0.43 Neutral MLH1 P40692 E694Y 694 E Y 0.398 Neutral MLH1 P40692 S695A 695 S A 0.01 Neutral MLH1 P40692 S695C 695 S C 0.032 Neutral MLH1 P40692 S695D 695 S D 0.002 Neutral MLH1 P40692 S695E 695 S E 0.138 Neutral MLH1 P40692 S695F 695 S F 0.264 Neutral MLH1 P40692 S695G 695 S G 0 Neutral MLH1 P40692 S695H 695 S H 0.188 Neutral MLH1 P40692 S695I 695 S I 0.124 Neutral MLH1 P40692 S695K 695 S K 0.14 Neutral MLH1 P40692 S695L 695 S L 0.032 Neutral MLH1 P40692 S695M 695 S M 0.332 Neutral MLH1 P40692 S695N 695 S N 0.034 Neutral MLH1 P40692 S695P 695 S P 0.062 Neutral MLH1 P40692 S695Q 695 S Q 0.186 Neutral MLH1 P40692 S695R 695 S R 0.136 Neutral MLH1 P40692 S695T 695 S T 0.02 Neutral MLH1 P40692 S695V 695 S V 0.134 Neutral MLH1 P40692 S695W 695 S W 0.49 Neutral MLH1 P40692 S695Y 695 S Y 0.448 Neutral MLH1 P40692 T696A 696 T A 0 Neutral MLH1 P40692 T696C 696 T C 0.034 Neutral MLH1 P40692 T696D 696 T D 0.02 Neutral MLH1 P40692 T696E 696 T E 0.024 Neutral MLH1 P40692 T696F 696 T F 0.198 Neutral MLH1 P40692 T696G 696 T G 0.036 Neutral MLH1 P40692 T696H 696 T H 0.084 Neutral MLH1 P40692 T696I 696 T I 0.096 Neutral MLH1 P40692 T696K 696 T K 0.026 Neutral MLH1 P40692 T696L 696 T L 0.044 Neutral MLH1 P40692 T696M 696 T M 0.098 Neutral MLH1 P40692 T696N 696 T N 0 Neutral MLH1 P40692 T696P 696 T P 0.008 Neutral MLH1 P40692 T696Q 696 T Q 0 Neutral MLH1 P40692 T696R 696 T R 0.14 Neutral MLH1 P40692 T696S 696 T S 0 Neutral MLH1 P40692 T696V 696 T V 0.046 Neutral MLH1 P40692 T696W 696 T W 0.466 Neutral MLH1 P40692 T696Y 696 T Y 0.424 Neutral MLH1 P40692 L697A 697 L A 0.008 Neutral MLH1 P40692 L697C 697 L C 0.094 Neutral MLH1 P40692 L697D 697 L D 0.038 Neutral MLH1 P40692 L697E 697 L E 0.028 Neutral MLH1 P40692 L697F 697 L F 0.204 Neutral MLH1 P40692 L697G 697 L G 0.052 Neutral MLH1 P40692 L697H 697 L H 0.04 Neutral MLH1 P40692 L697I 697 L I 0.03 Neutral MLH1 P40692 L697K 697 L K 0.178 Neutral MLH1 P40692 L697M 697 L M 0.132 Neutral MLH1 P40692 L697N 697 L N 0.04 Neutral MLH1 P40692 L697P 697 L P 0.09 Neutral MLH1 P40692 L697Q 697 L Q 0.048 Neutral MLH1 P40692 L697R 697 L R 0.236 Neutral MLH1 P40692 L697S 697 L S 0.026 Neutral MLH1 P40692 L697T 697 L T 0.096 Neutral MLH1 P40692 L697V 697 L V 0.08 Neutral MLH1 P40692 L697W 697 L W 0.334 Neutral MLH1 P40692 L697Y 697 L Y 0.298 Neutral MLH1 P40692 S698A 698 S A 0.018 Neutral MLH1 P40692 S698C 698 S C 0.022 Neutral MLH1 P40692 S698D 698 S D 0.008 Neutral MLH1 P40692 S698E 698 S E 0.138 Neutral MLH1 P40692 S698F 698 S F 0.276 Neutral MLH1 P40692 S698G 698 S G 0.066 Neutral MLH1 P40692 S698H 698 S H 0.238 Neutral MLH1 P40692 S698I 698 S I 0.124 Neutral MLH1 P40692 S698K 698 S K 0.146 Neutral MLH1 P40692 S698L 698 S L 0.062 Neutral MLH1 P40692 S698M 698 S M 0.28 Neutral MLH1 P40692 S698N 698 S N 0.018 Neutral MLH1 P40692 S698P 698 S P 0.132 Neutral MLH1 P40692 S698Q 698 S Q 0.16 Neutral MLH1 P40692 S698R 698 S R 0.152 Neutral MLH1 P40692 S698T 698 S T 0.02 Neutral MLH1 P40692 S698V 698 S V 0.248 Neutral MLH1 P40692 S698W 698 S W 0.49 Neutral MLH1 P40692 S698Y 698 S Y 0.448 Neutral MLH1 P40692 G699A 699 G A 0.002 Neutral MLH1 P40692 G699C 699 G C 0.14 Neutral MLH1 P40692 G699D 699 G D 0.134 Neutral MLH1 P40692 G699E 699 G E 0.192 Neutral MLH1 P40692 G699F 699 G F 0.388 Neutral MLH1 P40692 G699H 699 G H 0.324 Neutral MLH1 P40692 G699I 699 G I 0.416 Neutral MLH1 P40692 G699K 699 G K 0.284 Neutral MLH1 P40692 G699L 699 G L 0.316 Neutral MLH1 P40692 G699M 699 G M 0.422 Neutral MLH1 P40692 G699N 699 G N 0.182 Neutral MLH1 P40692 G699P 699 G P 0.392 Neutral MLH1 P40692 G699Q 699 G Q 0.21 Neutral MLH1 P40692 G699R 699 G R 0.304 Neutral MLH1 P40692 G699S 699 G S 0.01 Neutral MLH1 P40692 G699T 699 G T 0.27 Neutral MLH1 P40692 G699V 699 G V 0.328 Neutral MLH1 P40692 G699W 699 G W 0.498 Neutral MLH1 P40692 G699Y 699 G Y 0.44 Neutral MLH1 P40692 V7A 7 V A 0.05 Neutral MLH1 P40692 V7C 7 V C 0.09 Neutral MLH1 P40692 V7D 7 V D 0.202 Neutral MLH1 P40692 V7E 7 V E 0.332 Neutral MLH1 P40692 V7F 7 V F 0.374 Neutral MLH1 P40692 V7G 7 V G 0.286 Neutral MLH1 P40692 V7H 7 V H 0.228 Neutral MLH1 P40692 V7I 7 V I 0.006 Neutral MLH1 P40692 V7K 7 V K 0.082 Neutral MLH1 P40692 V7L 7 V L 0.128 Neutral MLH1 P40692 V7M 7 V M 0.17 Neutral MLH1 P40692 V7N 7 V N 0.222 Neutral MLH1 P40692 V7P 7 V P 0.348 Neutral MLH1 P40692 V7Q 7 V Q 0.358 Neutral MLH1 P40692 V7R 7 V R 0.32 Neutral MLH1 P40692 V7S 7 V S 0.076 Neutral MLH1 P40692 V7T 7 V T 0.034 Neutral MLH1 P40692 V7W 7 V W 0.552 Pathogenic MLH1 P40692 V7Y 7 V Y 0.47 Neutral MLH1 P40692 K70A 70 K A 0.252 Neutral MLH1 P40692 K70C 70 K C 0.088 Neutral MLH1 P40692 K70D 70 K D 0.1 Neutral MLH1 P40692 K70E 70 K E 0.156 Neutral MLH1 P40692 K70F 70 K F 0.77 Pathogenic MLH1 P40692 K70G 70 K G 0.36 Neutral MLH1 P40692 K70H 70 K H 0.038 Neutral MLH1 P40692 K70I 70 K I 0.734 Pathogenic MLH1 P40692 K70L 70 K L 0.138 Neutral MLH1 P40692 K70M 70 K M 0.656 Pathogenic MLH1 P40692 K70N 70 K N 0.15 Neutral MLH1 P40692 K70P 70 K P 0.1 Neutral MLH1 P40692 K70Q 70 K Q 0.4 Neutral MLH1 P40692 K70R 70 K R 0.04 Neutral MLH1 P40692 K70S 70 K S 0.16 Neutral MLH1 P40692 K70T 70 K T 0.07 Neutral MLH1 P40692 K70V 70 K V 0.63 Pathogenic MLH1 P40692 K70W 70 K W 0.976 Pathogenic MLH1 P40692 K70Y 70 K Y 0.328 Neutral MLH1 P40692 Q700A 700 Q A 0.036 Neutral MLH1 P40692 Q700C 700 Q C 0.048 Neutral MLH1 P40692 Q700D 700 Q D 0 Neutral MLH1 P40692 Q700E 700 Q E 0.008 Neutral MLH1 P40692 Q700F 700 Q F 0.362 Neutral MLH1 P40692 Q700G 700 Q G 0.03 Neutral MLH1 P40692 Q700H 700 Q H 0.034 Neutral MLH1 P40692 Q700I 700 Q I 0.228 Neutral MLH1 P40692 Q700K 700 Q K 0.02 Neutral MLH1 P40692 Q700L 700 Q L 0.116 Neutral MLH1 P40692 Q700M 700 Q M 0.21 Neutral MLH1 P40692 Q700N 700 Q N 0.018 Neutral MLH1 P40692 Q700P 700 Q P 0.26 Neutral MLH1 P40692 Q700R 700 Q R 0.004 Neutral MLH1 P40692 Q700S 700 Q S 0.034 Neutral MLH1 P40692 Q700T 700 Q T 0.002 Neutral MLH1 P40692 Q700V 700 Q V 0.036 Neutral MLH1 P40692 Q700W 700 Q W 0.402 Neutral MLH1 P40692 Q700Y 700 Q Y 0.452 Neutral MLH1 P40692 Q701A 701 Q A 0.05 Neutral MLH1 P40692 Q701C 701 Q C 0.16 Neutral MLH1 P40692 Q701D 701 Q D 0 Neutral MLH1 P40692 Q701E 701 Q E 0.008 Neutral MLH1 P40692 Q701F 701 Q F 0.536 Pathogenic MLH1 P40692 Q701G 701 Q G 0.184 Neutral MLH1 P40692 Q701H 701 Q H 0.356 Neutral 5 MLH1 P40692 Q701I 701 Q I 0.262 Neutral MLH1 P40692 Q701K 701 Q K 0.024 Neutral 2 MLH1 P40692 Q701L 701 Q L 0.132 Neutral MLH1 P40692 Q701M 701 Q M 0.024 Neutral MLH1 P40692 Q701N 701 Q N 0.022 Neutral MLH1 P40692 Q701P 701 Q P 0.284 Neutral MLH1 P40692 Q701R 701 Q R 0.008 Neutral MLH1 P40692 Q701S 701 Q S 0.044 Neutral MLH1 P40692 Q701T 701 Q T 0.006 Neutral MLH1 P40692 Q701V 701 Q V 0.03 Neutral MLH1 P40692 Q701W 701 Q W 0.684 Pathogenic MLH1 P40692 Q701Y 701 Q Y 0.612 Pathogenic MLH1 P40692 S702A 702 S A 0.01 Neutral MLH1 P40692 S702C 702 S C 0.024 Neutral MLH1 P40692 S702D 702 S D 0.002 Neutral MLH1 P40692 S702E 702 S E 0.16 Neutral MLH1 P40692 S702F 702 S F 0.34 Neutral MLH1 P40692 S702G 702 S G 0.002 Neutral MLH1 P40692 S702H 702 S H 0.292 Neutral MLH1 P40692 S702I 702 S I 0.202 Neutral MLH1 P40692 S702K 702 S K 0.188 Neutral MLH1 P40692 S702L 702 S L 0.046 Neutral MLH1 P40692 S702M 702 S M 0.364 Neutral MLH1 P40692 S702N 702 S N 0 Neutral MLH1 P40692 S702P 702 S P 0.124 Neutral MLH1 P40692 S702Q 702 S Q 0.192 Neutral MLH1 P40692 S702R 702 S R 0.176 Neutral MLH1 P40692 S702T 702 S T 0.02 Neutral MLH1 P40692 S702V 702 S V 0.032 Neutral MLH1 P40692 S702W 702 S W 0.56 Pathogenic MLH1 P40692 S702Y 702 S Y 0.518 Pathogenic MLH1 P40692 E703A 703 E A 0.078 Neutral MLH1 P40692 E703C 703 E C 0.114 Neutral MLH1 P40692 E703D 703 E D 0.004 Neutral MLH1 P40692 E703F 703 E F 0.484 Neutral MLH1 P40692 E703G 703 E G 0.086 Neutral MLH1 P40692 E703H 703 E H 0.13 Neutral MLH1 P40692 E703I 703 E I 0.208 Neutral MLH1 P40692 E703K 703 E K 0.01 Neutral MLH1 P40692 E703L 703 E L 0.062 Neutral MLH1 P40692 E703M 703 E M 0.302 Neutral MLH1 P40692 E703N 703 E N 0.004 Neutral MLH1 P40692 E703P 703 E P 0.188 Neutral MLH1 P40692 E703Q 703 E Q 0.002 Neutral MLH1 P40692 E703R 703 E R 0.024 Neutral MLH1 P40692 E703S 703 E S 0.02 Neutral MLH1 P40692 E703T 703 E T 0.014 Neutral MLH1 P40692 E703V 703 E V 0.382 Neutral MLH1 P40692 E703W 703 E W 0.714 Pathogenic MLH1 P40692 E703Y 703 E Y 0.662 Pathogenic MLH1 P40692 V704A 704 V A 0.006 Neutral MLH1 P40692 V704C 704 V C 0.09 Neutral MLH1 P40692 V704D 704 V D 0.04 Neutral MLH1 P40692 V704E 704 V E 0.068 Neutral MLH1 P40692 V704F 704 V F 0.366 Neutral MLH1 P40692 V704G 704 V G 0.07 Neutral MLH1 P40692 V704H 704 V H 0.096 Neutral MLH1 P40692 V704I 704 V I 0.14 Neutral MLH1 P40692 V704K 704 V K 0.092 Neutral MLH1 P40692 V704L 704 V L 0.004 Neutral MLH1 P40692 V704M 704 V M 0.032 Neutral MLH1 P40692 V704N 704 V N 0.054 Neutral MLH1 P40692 V704P 704 V P 0.148 Neutral MLH1 P40692 V704Q 704 V Q 0.078 Neutral MLH1 P40692 V704R 704 V R 0.36 Neutral MLH1 P40692 V704S 704 V S 0.022 Neutral MLH1 P40692 V704T 704 V T 0.13 Neutral MLH1 P40692 V704W 704 V W 0.538 Pathogenic MLH1 P40692 V704Y 704 V Y 0.458 Neutral MLH1 P40692 P705A 705 P A 0.116 Neutral MLH1 P40692 P705C 705 P C 0.148 Neutral MLH1 P40692 P705D 705 P D 0.008 Neutral MLH1 P40692 P705E 705 P E 0.054 Neutral MLH1 P40692 P705F 705 P F 0.272 Neutral MLH1 P40692 P705G 705 P G 0.01 Neutral MLH1 P40692 P705H 705 P H 0.266 Neutral MLH1 P40692 P705I 705 P I 0.042 Neutral MLH1 P40692 P705K 705 P K 0.206 Neutral MLH1 P40692 P705L 705 P L 0.044 Neutral MLH1 P40692 P705M 705 P M 0.178 Neutral MLH1 P40692 P705N 705 P N 0.048 Neutral MLH1 P40692 P705Q 705 P Q 0.052 Neutral MLH1 P40692 P705R 705 P R 0.202 Neutral MLH1 P40692 P705S 705 P S 0.004 Neutral MLH1 P40692 P705T 705 P T 0.122 Neutral MLH1 P40692 P705V 705 P V 0.038 Neutral MLH1 P40692 P705W 705 P W 0.296 Neutral MLH1 P40692 P705Y 705 P Y 0.32 Neutral MLH1 P40692 G706A 706 G A 0.002 Neutral MLH1 P40692 G706C 706 G C 0.14 Neutral MLH1 P40692 G706D 706 G D 0.134 Neutral MLH1 P40692 G706E 706 G E 0.304 Neutral MLH1 P40692 G706F 706 G F 0.478 Neutral MLH1 P40692 G706H 706 G H 0.442 Neutral MLH1 P40692 G706I 706 G I 0.408 Neutral MLH1 P40692 G706K 706 G K 0.358 Neutral MLH1 P40692 G706L 706 G L 0.33 Neutral MLH1 P40692 G706M 706 G M 0.282 Neutral MLH1 P40692 G706N 706 G N 0.252 Neutral MLH1 P40692 G706P 706 G P 0.392 Neutral MLH1 P40692 G706Q 706 G Q 0.262 Neutral MLH1 P40692 G706R 706 G R 0.468 Neutral MLH1 P40692 G706S 706 G S 0.016 Neutral MLH1 P40692 G706T 706 G T 0.26 Neutral MLH1 P40692 G706V 706 G V 0.394 Neutral MLH1 P40692 G706W 706 G W 0.498 Neutral MLH1 P40692 G706Y 706 G Y 0.482 Neutral MLH1 P40692 S707A 707 S A 0.018 Neutral MLH1 P40692 S707C 707 S C 0.022 Neutral MLH1 P40692 S707D 707 S D 0.008 Neutral MLH1 P40692 S707E 707 S E 0.14 Neutral MLH1 P40692 S707F 707 S F 0.28 Neutral MLH1 P40692 S707G 707 S G 0 Neutral MLH1 P40692 S707H 707 S H 0.242 Neutral MLH1 P40692 S707I 707 S I 0.126 Neutral MLH1 P40692 S707K 707 S K 0.146 Neutral MLH1 P40692 S707L 707 S L 0.028 Neutral MLH1 P40692 S707M 707 S M 0.35 Neutral MLH1 P40692 S707N 707 S N 0.034 Neutral MLH1 P40692 S707P 707 S P 0.062 Neutral MLH1 P40692 S707Q 707 S Q 0.162 Neutral MLH1 P40692 S707R 707 S R 0.154 Neutral MLH1 P40692 S707T 707 S T 0.178 Neutral MLH1 P40692 S707V 707 S V 0.138 Neutral MLH1 P40692 S707W 707 S W 0.502 Pathogenic MLH1 P40692 S707Y 707 S Y 0.458 Neutral MLH1 P40692 I708A 708 I A 0.006 Neutral MLH1 P40692 I708C 708 I C 0.066 Neutral MLH1 P40692 I708D 708 I D 0.14 Neutral MLH1 P40692 I708E 708 I E 0.132 Neutral MLH1 P40692 I708F 708 I F 0.206 Neutral MLH1 P40692 I708G 708 I G 0.134 Neutral MLH1 P40692 I708H 708 I H 0.08 Neutral MLH1 P40692 I708K 708 I K 0.148 Neutral MLH1 P40692 I708L 708 I L 0.108 Neutral MLH1 P40692 I708M 708 I M 0.084 Neutral MLH1 P40692 I708N 708 I N 0.234 Neutral MLH1 P40692 I708P 708 I P 0.066 Neutral MLH1 P40692 I708Q 708 I Q 0.174 Neutral MLH1 P40692 I708R 708 I R 0.232 Neutral MLH1 P40692 I708S 708 I S 0.072 Neutral MLH1 P40692 I708T 708 I T 0.002 Neutral MLH1 P40692 I708V 708 I V 0.122 Neutral MLH1 P40692 I708W 708 I W 0.344 Neutral MLH1 P40692 I708Y 708 I Y 0.298 Neutral MLH1 P40692 P709A 709 P A 0.032 Neutral MLH1 P40692 P709C 709 P C 0.148 Neutral MLH1 P40692 P709D 709 P D 0.078 Neutral MLH1 P40692 P709E 709 P E 0.166 Neutral MLH1 P40692 P709F 709 P F 0.272 Neutral MLH1 P40692 P709G 709 P G 0.066 Neutral MLH1 P40692 P709H 709 P H 0.266 Neutral MLH1 P40692 P709I 709 P I 0.1 Neutral MLH1 P40692 P709K 709 P K 0.144 Neutral MLH1 P40692 P709L 709 P L 0.096 Neutral MLH1 P40692 P709M 709 P M 0.178 Neutral MLH1 P40692 P709N 709 P N 0.068 Neutral MLH1 P40692 P709Q 709 P Q 0.212 Neutral MLH1 P40692 P709R 709 P R 0.214 Neutral MLH1 P40692 P709S 709 P S 0.002 Neutral MLH1 P40692 P709T 709 P T 0.034 Neutral MLH1 P40692 P709V 709 P V 0.184 Neutral MLH1 P40692 P709W 709 P W 0.39 Neutral MLH1 P40692 P709Y 709 P Y 0.32 Neutral MLH1 P40692 E71A 71 E A 0.234 Neutral MLH1 P40692 E71C 71 E C 0.49 Neutral MLH1 P40692 E71D 71 E D 0.018 Neutral MLH1 P40692 E71F 71 E F 0.882 Pathogenic MLH1 P40692 E71G 71 E G 0.05 Neutral MLH1 P40692 E71H 71 E H 0.618 Pathogenic MLH1 P40692 E71I 71 E I 0.848 Pathogenic MLH1 P40692 E71K 71 E K 0.66 Pathogenic MLH1 P40692 E71L 71 E L 0.44 Neutral MLH1 P40692 E71M 71 E M 0.722 Pathogenic MLH1 P40692 E71N 71 E N 0.136 Neutral MLH1 P40692 E71P 71 E P 0.892 Pathogenic MLH1 P40692 E71Q 71 E Q 0.02 Neutral MLH1 P40692 E71R 71 E R 0.588 Pathogenic MLH1 P40692 E71S 71 E S 0.052 Neutral MLH1 P40692 E71T 71 E T 0.062 Neutral MLH1 P40692 E71V 71 E V 0.424 Neutral MLH1 P40692 E71W 71 E W 0.972 Pathogenic MLH1 P40692 E71Y 71 E Y 0.92 Pathogenic MLH1 P40692 N710A 710 N A 0.07 Neutral MLH1 P40692 N710C 710 N C 0.148 Neutral MLH1 P40692 N710D 710 N D 0.028 Neutral MLH1 P40692 N710E 710 N E 0.096 Neutral MLH1 P40692 N710F 710 N F 0.34 Neutral MLH1 P40692 N710G 710 N G 0.162 Neutral MLH1 P40692 N710H 710 N H 0.23 Neutral MLH1 P40692 N710I 710 N I 0.266 Neutral MLH1 P40692 N710K 710 N K 0.042 Neutral MLH1 P40692 N710L 710 N L 0.272 Neutral MLH1 P40692 N710M 710 N M 0.22 Neutral MLH1 P40692 N710P 710 N P 0.132 Neutral MLH1 P40692 N710Q 710 N Q 0.114 Neutral MLH1 P40692 N710R 710 N R 0.158 Neutral MLH1 P40692 N710S 710 N S 0 Neutral MLH1 P40692 N710T 710 N T 0.008 Neutral MLH1 P40692 N710V 710 N V 0.032 Neutral MLH1 P40692 N710W 710 N W 0.404 Neutral MLH1 P40692 N710Y 710 N Y 0.402 Neutral MLH1 P40692 S711A 711 S A 0.012 Neutral MLH1 P40692 S711C 711 S C 0.032 Neutral MLH1 P40692 S711D 711 S D 0.002 Neutral MLH1 P40692 S711E 711 S E 0.114 Neutral MLH1 P40692 S711F 711 S F 0.276 Neutral MLH1 P40692 S711G 711 S G 0.066 Neutral MLH1 P40692 S711H 711 S H 0.188 Neutral MLH1 P40692 S711I 711 S I 0.026 Neutral MLH1 P40692 S711K 711 S K 0.15 Neutral MLH1 P40692 S711L 711 S L 0.028 Neutral MLH1 P40692 S711M 711 S M 0.332 Neutral MLH1 P40692 S711N 711 S N 0.002 Neutral MLH1 P40692 S711P 711 S P 0.058 Neutral MLH1 P40692 S711Q 711 S Q 0.132 Neutral MLH1 P40692 S711R 711 S R 0.248 Neutral MLH1 P40692 S711T 711 S T 0.046 Neutral MLH1 P40692 S711V 711 S V 0.288 Neutral MLH1 P40692 S711W 711 S W 0.49 Neutral MLH1 P40692 S711Y 711 S Y 0.404 Neutral MLH1 P40692 W712A 712 W A 0.308 Neutral MLH1 P40692 W712C 712 W C 0.258 Neutral MLH1 P40692 W712D 712 W D 0.384 Neutral MLH1 P40692 W712E 712 W E 0.528 Pathogenic MLH1 P40692 W712F 712 W F 0.208 Neutral MLH1 P40692 W712G 712 W G 0.286 Neutral MLH1 P40692 W712H 712 W H 0.114 Neutral MLH1 P40692 W712I 712 W I 0.336 Neutral MLH1 P40692 W712K 712 W K 0.178 Neutral MLH1 P40692 W712L 712 W L 0.218 Neutral MLH1 P40692 W712M 712 W M 0.28 Neutral MLH1 P40692 W712N 712 W N 0.292 Neutral MLH1 P40692 W712P 712 W P 0.338 Neutral MLH1 P40692 W712Q 712 W Q 0.31 Neutral MLH1 P40692 W712R 712 W R 0.076 Neutral MLH1 P40692 W712S 712 W S 0.27 Neutral MLH1 P40692 W712T 712 W T 0.258 Neutral MLH1 P40692 W712V 712 W V 0.28 Neutral MLH1 P40692 W712Y 712 W Y 0.096 Neutral MLH1 P40692 K713A 713 K A 0.25 Neutral MLH1 P40692 K713C 713 K C 0.2 Neutral MLH1 P40692 K713D 713 K D 0.236 Neutral MLH1 P40692 K713E 713 K E 0.032 Neutral MLH1 P40692 K713F 713 K F 0.714 Pathogenic MLH1 P40692 K713G 713 K G 0.37 Neutral MLH1 P40692 K713H 713 K H 0.026 Neutral MLH1 P40692 K713I 713 K I 0.762 Pathogenic MLH1 P40692 K713L 713 K L 0.662 Pathogenic MLH1 P40692 K713M 713 K M 0.542 Pathogenic MLH1 P40692 K713N 713 K N 0.242 Neutral MLH1 P40692 K713P 713 K P 0.752 Pathogenic MLH1 P40692 K713Q 713 K Q 0.076 Neutral MLH1 P40692 K713R 713 K R 0.032 Neutral MLH1 P40692 K713S 713 K S 0.6 Pathogenic MLH1 P40692 K713T 713 K T 0.528 Pathogenic MLH1 P40692 K713V 713 K V 0.706 Pathogenic MLH1 P40692 K713W 713 K W 0.914 Pathogenic MLH1 P40692 K713Y 713 K Y 0.844 Pathogenic MLH1 P40692 W714A 714 W A 0.246 Neutral MLH1 P40692 W714C 714 W C 0.246 Neutral MLH1 P40692 W714D 714 W D 0.356 Neutral MLH1 P40692 W714E 714 W E 0.514 Pathogenic MLH1 P40692 W714F 714 W F 0.202 Neutral MLH1 P40692 W714G 714 W G 0.272 Neutral MLH1 P40692 W714H 714 W H 0.07 Neutral MLH1 P40692 W714I 714 W I 0.4 Neutral MLH1 P40692 W714K 714 W K 0.5 Pathogenic MLH1 P40692 W714L 714 W L 0.212 Neutral MLH1 P40692 W714M 714 W M 0.266 Neutral MLH1 P40692 W714N 714 W N 0.278 Neutral MLH1 P40692 W714P 714 W P 0.314 Neutral MLH1 P40692 W714Q 714 W Q 0.176 Neutral MLH1 P40692 W714R 714 W R 0.076 Neutral MLH1 P40692 W714S 714 W S 0.172 Neutral MLH1 P40692 W714T 714 W T 0.286 Neutral MLH1 P40692 W714V 714 W V 0.262 Neutral MLH1 P40692 W714Y 714 W Y 0.03 Neutral MLH1 P40692 T715A 715 T A 0 Neutral MLH1 P40692 T715C 715 T C 0.114 Neutral MLH1 P40692 T715D 715 T D 0.108 Neutral MLH1 P40692 T715E 715 T E 0.054 Neutral MLH1 P40692 T715F 715 T F 0.426 Neutral MLH1 P40692 T715G 715 T G 0.092 Neutral MLH1 P40692 T715H 715 T H 0.182 Neutral MLH1 P40692 T715I 715 T I 0.048 Neutral MLH1 P40692 T715K 715 T K 0.01 Neutral MLH1 P40692 T715L 715 T L 0.024 Neutral MLH1 P40692 T715M 715 T M 0.058 Neutral MLH1 P40692 T715N 715 T N 0.016 Neutral MLH1 P40692 T715P 715 T P 0.226 Neutral MLH1 P40692 T715Q 715 T Q 0.024 Neutral MLH1 P40692 T715R 715 T R 0.438 Neutral MLH1 P40692 T715S 715 T S 0 Neutral MLH1 P40692 T715V 715 T V 0.018 Neutral MLH1 P40692 T715W 715 T W 0.708 Pathogenic MLH1 P40692 T715Y 715 T Y 0.51 Pathogenic MLH1 P40692 V716A 716 V A 0.13 Neutral MLH1 P40692 V716C 716 V C 0.304 Neutral MLH1 P40692 V716D 716 V D 0.508 Pathogenic MLH1 P40692 V716E 716 V E 0.554 Pathogenic MLH1 P40692 V716F 716 V F 0.438 Neutral MLH1 P40692 V716G 716 V G 0.578 Pathogenic MLH1 P40692 V716H 716 V H 0.422 Neutral MLH1 P40692 V716I 716 V I 0.04 Neutral MLH1 P40692 V716K 716 V K 0.678 Pathogenic MLH1 P40692 V716L 716 V L 0.038 Neutral MLH1 P40692 V716M 716 V M 0.044 Neutral 1 MLH1 P40692 V716N 716 V N 0.546 Pathogenic MLH1 P40692 V716P 716 V P 0.772 Pathogenic MLH1 P40692 V716Q 716 V Q 0.638 Pathogenic MLH1 P40692 V716R 716 V R 0.786 Pathogenic MLH1 P40692 V716S 716 V S 0.362 Neutral MLH1 P40692 V716T 716 V T 0.024 Neutral MLH1 P40692 V716W 716 V W 0.762 Pathogenic MLH1 P40692 V716Y 716 V Y 0.742 Pathogenic MLH1 P40692 E717A 717 E A 0.572 Pathogenic MLH1 P40692 E717C 717 E C 0.48 Neutral MLH1 P40692 E717D 717 E D 0.078 Neutral MLH1 P40692 E717F 717 E F 0.826 Pathogenic MLH1 P40692 E717G 717 E G 0.182 Neutral MLH1 P40692 E717H 717 E H 0.548 Pathogenic MLH1 P40692 E717I 717 E I 0.888 Pathogenic MLH1 P40692 E717K 717 E K 0.678 Pathogenic MLH1 P40692 E717L 717 E L 0.726 Pathogenic MLH1 P40692 E717M 717 E M 0.654 Pathogenic MLH1 P40692 E717N 717 E N 0.366 Neutral MLH1 P40692 E717P 717 E P 0.826 Pathogenic MLH1 P40692 E717Q 717 E Q 0.012 Neutral MLH1 P40692 E717R 717 E R 0.608 Pathogenic MLH1 P40692 E717S 717 E S 0.302 Neutral MLH1 P40692 E717T 717 E T 0.546 Pathogenic MLH1 P40692 E717V 717 E V 0.792 Pathogenic MLH1 P40692 E717W 717 E W 0.936 Pathogenic MLH1 P40692 E717Y 717 E Y 0.882 Pathogenic MLH1 P40692 H718A 718 H A 0.36 Neutral MLH1 P40692 H718C 718 H C 0.286 Neutral MLH1 P40692 H718D 718 H D 0.076 Neutral MLH1 P40692 H718E 718 H E 0.122 Neutral MLH1 P40692 H718F 718 H F 0.204 Neutral MLH1 P40692 H718G 718 H G 0.316 Neutral MLH1 P40692 H718I 718 H I 0.78 Pathogenic MLH1 P40692 H718K 718 H K 0.608 Pathogenic MLH1 P40692 H718L 718 H L 0.728 Pathogenic MLH1 P40692 H718M 718 H M 0.624 Pathogenic MLH1 P40692 H718N 718 H N 0.022 Neutral MLH1 P40692 H718P 718 H P 0.906 Pathogenic MLH1 P40692 H718Q 718 H Q 0.1 Neutral MLH1 P40692 H718R 718 H R 0.068 Neutral MLH1 P40692 H718S 718 H S 0.39 Neutral MLH1 P40692 H718T 718 H T 0.39 Neutral MLH1 P40692 H718V 718 H V 0.534 Pathogenic MLH1 P40692 H718W 718 H W 0.954 Pathogenic MLH1 P40692 H718Y 718 H Y 0.1 Neutral 1 MLH1 P40692 I719A 719 I A 0.05 Neutral MLH1 P40692 I719C 719 I C 0.28 Neutral MLH1 P40692 I719D 719 I D 0.628 Pathogenic MLH1 P40692 I719E 719 I E 0.612 Pathogenic MLH1 P40692 I719F 719 I F 0.536 Pathogenic MLH1 P40692 I719G 719 I G 0.598 Pathogenic MLH1 P40692 I719H 719 I H 0.512 Pathogenic MLH1 P40692 I719K 719 I K 0.466 Neutral MLH1 P40692 I719L 719 I L 0.004 Neutral MLH1 P40692 I719M 719 I M 0.398 Neutral MLH1 P40692 I719N 719 I N 0.584 Pathogenic MLH1 P40692 I719P 719 I P 0.76 Pathogenic MLH1 P40692 I719Q 719 I Q 0.646 Pathogenic MLH1 P40692 I719R 719 I R 0.742 Pathogenic MLH1 P40692 I719S 719 I S 0.426 Neutral MLH1 P40692 I719T 719 I T 0.02 Neutral MLH1 P40692 I719V 719 I V 0.154 Neutral MLH1 P40692 I719W 719 I W 0.878 Pathogenic MLH1 P40692 I719Y 719 I Y 0.64 Pathogenic MLH1 P40692 D72A 72 D A 0.788 Pathogenic MLH1 P40692 D72C 72 D C 0.898 Pathogenic MLH1 P40692 D72E 72 D E 0.88 Pathogenic MLH1 P40692 D72F 72 D F 0.982 Pathogenic MLH1 P40692 D72G 72 D G 0.362 Neutral MLH1 P40692 D72H 72 D H 0.61 Pathogenic MLH1 P40692 D72I 72 D I 0.972 Pathogenic MLH1 P40692 D72K 72 D K 0.95 Pathogenic MLH1 P40692 D72L 72 D L 0.976 Pathogenic MLH1 P40692 D72M 72 D M 0.958 Pathogenic MLH1 P40692 D72N 72 D N 0.348 Neutral MLH1 P40692 D72P 72 D P 0.892 Pathogenic MLH1 P40692 D72Q 72 D Q 0.678 Pathogenic MLH1 P40692 D72R 72 D R 0.956 Pathogenic MLH1 P40692 D72S 72 D S 0.626 Pathogenic MLH1 P40692 D72T 72 D T 0.81 Pathogenic MLH1 P40692 D72V 72 D V 0.992 Pathogenic MLH1 P40692 D72W 72 D W 0.98 Pathogenic MLH1 P40692 D72Y 72 D Y 0.972 Pathogenic MLH1 P40692 V720A 720 V A 0.138 Neutral MLH1 P40692 V720C 720 V C 0.394 Neutral MLH1 P40692 V720D 720 V D 0.602 Pathogenic MLH1 P40692 V720E 720 V E 0.706 Pathogenic MLH1 P40692 V720F 720 V F 0.466 Neutral MLH1 P40692 V720G 720 V G 0.472 Neutral MLH1 P40692 V720H 720 V H 0.544 Pathogenic MLH1 P40692 V720I 720 V I 0.04 Neutral MLH1 P40692 V720K 720 V K 0.788 Pathogenic MLH1 P40692 V720L 720 V L 0.096 Neutral MLH1 P40692 V720M 720 V M 0.262 Neutral MLH1 P40692 V720N 720 V N 0.638 Pathogenic MLH1 P40692 V720P 720 V P 0.86 Pathogenic MLH1 P40692 V720Q 720 V Q 0.72 Pathogenic MLH1 P40692 V720R 720 V R 0.838 Pathogenic MLH1 P40692 V720S 720 V S 0.442 Neutral MLH1 P40692 V720T 720 V T 0.388 Neutral MLH1 P40692 V720W 720 V W 0.494 Neutral MLH1 P40692 V720Y 720 V Y 0.83 Pathogenic MLH1 P40692 Y721A 721 Y A 0.208 Neutral MLH1 P40692 Y721C 721 Y C 0.202 Neutral MLH1 P40692 Y721D 721 Y D 0.682 Pathogenic MLH1 P40692 Y721E 721 Y E 0.646 Pathogenic MLH1 P40692 Y721F 721 Y F 0.112 Neutral MLH1 P40692 Y721G 721 Y G 0.208 Neutral MLH1 P40692 Y721H 721 Y H 0.36 Neutral MLH1 P40692 Y721I 721 Y I 0.56 Pathogenic MLH1 P40692 Y721K 721 Y K 0.7 Pathogenic MLH1 P40692 Y721L 721 Y L 0.12 Neutral MLH1 P40692 Y721M 721 Y M 0.118 Neutral MLH1 P40692 Y721N 721 Y N 0.498 Neutral MLH1 P40692 Y721P 721 Y P 0.27 Neutral MLH1 P40692 Y721Q 721 Y Q 0.446 Neutral MLH1 P40692 Y721R 721 Y R 0.694 Pathogenic MLH1 P40692 Y721S 721 Y S 0.24 Neutral MLH1 P40692 Y721T 721 Y T 0.44 Neutral MLH1 P40692 Y721V 721 Y V 0.366 Neutral MLH1 P40692 Y721W 721 Y W 0.33 Neutral MLH1 P40692 K722A 722 K A 0.108 Neutral MLH1 P40692 K722C 722 K C 0.22 Neutral MLH1 P40692 K722D 722 K D 0.018 Neutral MLH1 P40692 K722E 722 K E 0.4 Neutral MLH1 P40692 K722F 722 K F 0.854 Pathogenic MLH1 P40692 K722G 722 K G 0.288 Neutral MLH1 P40692 K722H 722 K H 0.424 Neutral MLH1 P40692 K722I 722 K I 0.898 Pathogenic MLH1 P40692 K722L 722 K L 0.862 Pathogenic MLH1 P40692 K722M 722 K M 0.652 Pathogenic MLH1 P40692 K722N 722 K N 0.05 Neutral MLH1 P40692 K722P 722 K P 0.28 Neutral MLH1 P40692 K722Q 722 K Q 0.086 Neutral MLH1 P40692 K722R 722 K R 0.036 Neutral MLH1 P40692 K722S 722 K S 0.024 Neutral MLH1 P40692 K722T 722 K T 0.058 Neutral MLH1 P40692 K722V 722 K V 0.618 Pathogenic MLH1 P40692 K722W 722 K W 0.97 Pathogenic MLH1 P40692 K722Y 722 K Y 0.93 Pathogenic MLH1 P40692 A723C 723 A C 0.168 Neutral MLH1 P40692 A723D 723 A D 0.846 Pathogenic MLH1 P40692 A723E 723 A E 0.598 Pathogenic MLH1 P40692 A723F 723 A F 0.96 Pathogenic MLH1 P40692 A723G 723 A G 0.15 Neutral MLH1 P40692 A723H 723 A H 0.854 Pathogenic MLH1 P40692 A723I 723 A I 0.926 Pathogenic MLH1 P40692 A723K 723 A K 0.9 Pathogenic MLH1 P40692 A723L 723 A L 0.57 Pathogenic MLH1 P40692 A723M 723 A M 0.788 Pathogenic MLH1 P40692 A723N 723 A N 0.63 Pathogenic MLH1 P40692 A723P 723 A P 0.928 Pathogenic MLH1 P40692 A723Q 723 A Q 0.706 Pathogenic MLH1 P40692 A723R 723 A R 0.874 Pathogenic MLH1 P40692 A723S 723 A S 0.008 Neutral MLH1 P40692 A723T 723 A T 0.038 Neutral MLH1 P40692 A723V 723 A V 0.156 Neutral MLH1 P40692 A723W 723 A W 0.95 Pathogenic MLH1 P40692 A723Y 723 A Y 0.934 Pathogenic MLH1 P40692 L724A 724 L A 0.066 Neutral MLH1 P40692 L724C 724 L C 0.026 Neutral MLH1 P40692 L724D 724 L D 0.608 Pathogenic MLH1 P40692 L724E 724 L E 0.562 Pathogenic MLH1 P40692 L724F 724 L F 0.386 Neutral MLH1 P40692 L724G 724 L G 0.536 Pathogenic MLH1 P40692 L724H 724 L H 0.346 Neutral MLH1 P40692 L724I 724 L I 0.038 Neutral MLH1 P40692 L724K 724 L K 0.448 Neutral MLH1 P40692 L724M 724 L M 0.014 Neutral MLH1 P40692 L724N 724 L N 0.562 Pathogenic MLH1 P40692 L724P 724 L P 0.914 Pathogenic MLH1 P40692 L724Q 724 L Q 0.3 Neutral MLH1 P40692 L724R 724 L R 0.856 Pathogenic MLH1 P40692 L724S 724 L S 0.384 Neutral MLH1 P40692 L724T 724 L T 0.22 Neutral MLH1 P40692 L724V 724 L V 0.014 Neutral MLH1 P40692 L724W 724 L W 0.864 Pathogenic MLH1 P40692 L724Y 724 L Y 0.876 Pathogenic MLH1 P40692 R725A 725 R A 0.194 Neutral MLH1 P40692 R725C 725 R C 0.766 Pathogenic MLH1 P40692 R725D 725 R D 0.702 Pathogenic MLH1 P40692 R725E 725 R E 0.638 Pathogenic MLH1 P40692 R725F 725 R F 0.926 Pathogenic MLH1 P40692 R725G 725 R G 0.324 Neutral MLH1 P40692 R725H 725 R H 0.448 Neutral MLH1 P40692 R725I 725 R I 0.926 Pathogenic MLH1 P40692 R725K 725 R K 0.482 Neutral MLH1 P40692 R725L 725 R L 0.678 Pathogenic MLH1 P40692 R725M 725 R M 0.686 Pathogenic MLH1 P40692 R725N 725 R N 0.144 Neutral MLH1 P40692 R725P 725 R P 0.894 Pathogenic MLH1 P40692 R725Q 725 R Q 0.386 Neutral MLH1 P40692 R725S 725 R S 0.672 Pathogenic MLH1 P40692 R725T 725 R T 0.374 Neutral MLH1 P40692 R725V 725 R V 0.384 Neutral MLH1 P40692 R725W 725 R W 0.9 Pathogenic MLH1 P40692 R725Y 725 R Y 0.892 Pathogenic MLH1 P40692 S726A 726 S A 0.01 Neutral MLH1 P40692 S726C 726 S C 0.076 Neutral MLH1 P40692 S726D 726 S D 0.006 Neutral MLH1 P40692 S726E 726 S E 0.254 Neutral MLH1 P40692 S726F 726 S F 0.446 Neutral MLH1 P40692 S726G 726 S G 0.12 Neutral MLH1 P40692 S726H 726 S H 0.408 Neutral MLH1 P40692 S726I 726 S I 0.188 Neutral MLH1 P40692 S726K 726 S K 0.276 Neutral MLH1 P40692 S726L 726 S L 0.046 Neutral MLH1 P40692 S726M 726 S M 0.482 Neutral MLH1 P40692 S726N 726 S N 0.006 Neutral MLH1 P40692 S726P 726 S P 0.226 Neutral MLH1 P40692 S726Q 726 S Q 0.294 Neutral MLH1 P40692 S726R 726 S R 0.274 Neutral MLH1 P40692 S726T 726 S T 0.016 Neutral MLH1 P40692 S726V 726 S V 0.056 Neutral MLH1 P40692 S726W 726 S W 0.78 Pathogenic MLH1 P40692 S726Y 726 S Y 0.74 Pathogenic MLH1 P40692 H727A 727 H A 0.122 Neutral MLH1 P40692 H727C 727 H C 0.07 Neutral MLH1 P40692 H727D 727 H D 0 Neutral MLH1 P40692 H727E 727 H E 0.1 Neutral MLH1 P40692 H727F 727 H F 0.04 Neutral MLH1 P40692 H727G 727 H G 0.204 Neutral MLH1 P40692 H727I 727 H I 0.462 Neutral MLH1 P40692 H727K 727 H K 0.006 Neutral MLH1 P40692 H727L 727 H L 0.022 Neutral MLH1 P40692 H727M 727 H M 0.158 Neutral MLH1 P40692 H727N 727 H N 0.002 Neutral MLH1 P40692 H727P 727 H P 0.468 Neutral MLH1 P40692 H727Q 727 H Q 0.006 Neutral MLH1 P40692 H727R 727 H R 0.01 Neutral MLH1 P40692 H727S 727 H S 0.014 Neutral MLH1 P40692 H727T 727 H T 0.106 Neutral MLH1 P40692 H727V 727 H V 0.27 Neutral MLH1 P40692 H727W 727 H W 0.688 Pathogenic MLH1 P40692 H727Y 727 H Y 0.036 Neutral MLH1 P40692 I728A 728 I A 0.15 Neutral MLH1 P40692 I728C 728 I C 0.434 Neutral MLH1 P40692 I728D 728 I D 0.61 Pathogenic MLH1 P40692 I728E 728 I E 0.598 Pathogenic MLH1 P40692 I728F 728 I F 0.148 Neutral MLH1 P40692 I728G 728 I G 0.588 Pathogenic MLH1 P40692 I728H 728 I H 0.514 Pathogenic MLH1 P40692 I728K 728 I K 0.442 Neutral MLH1 P40692 I728L 728 I L 0.15 Neutral MLH1 P40692 I728M 728 I M 0.04 Neutral MLH1 P40692 I728N 728 I N 0.654 Pathogenic MLH1 P40692 I728P 728 I P 0.71 Pathogenic MLH1 P40692 I728Q 728 I Q 0.634 Pathogenic MLH1 P40692 I728R 728 I R 0.54 Pathogenic MLH1 P40692 I728S 728 I S 0.388 Neutral MLH1 P40692 I728T 728 I T 0.028 Neutral MLH1 P40692 I728V 728 I V 0.02 Neutral MLH1 P40692 I728W 728 I W 0.85 Pathogenic MLH1 P40692 I728Y 728 I Y 0.842 Pathogenic MLH1 P40692 L729A 729 L A 0.042 Neutral MLH1 P40692 L729C 729 L C 0.294 Neutral MLH1 P40692 L729D 729 L D 0.568 Pathogenic MLH1 P40692 L729E 729 L E 0.534 Pathogenic MLH1 P40692 L729F 729 L F 0.258 Neutral MLH1 P40692 L729G 729 L G 0.114 Neutral MLH1 P40692 L729H 729 L H 0.178 Neutral MLH1 P40692 L729I 729 L I 0.038 Neutral MLH1 P40692 L729K 729 L K 0.032 Neutral MLH1 P40692 L729M 729 L M 0.024 Neutral MLH1 P40692 L729N 729 L N 0.55 Pathogenic MLH1 P40692 L729P 729 L P 0.342 Neutral MLH1 P40692 L729Q 729 L Q 0.036 Neutral MLH1 P40692 L729R 729 L R 0.756 Pathogenic MLH1 P40692 L729S 729 L S 0.042 Neutral MLH1 P40692 L729T 729 L T 0.048 Neutral MLH1 P40692 L729V 729 L V 0.006 Neutral MLH1 P40692 L729W 729 L W 0.824 Pathogenic MLH1 P40692 L729Y 729 L Y 0.718 Pathogenic MLH1 P40692 L73A 73 L A 0.57 Pathogenic MLH1 P40692 L73C 73 L C 0.698 Pathogenic MLH1 P40692 L73D 73 L D 0.91 Pathogenic MLH1 P40692 L73E 73 L E 0.888 Pathogenic MLH1 P40692 L73F 73 L F 0.482 Neutral MLH1 P40692 L73G 73 L G 0.806 Pathogenic MLH1 P40692 L73H 73 L H 0.806 Pathogenic MLH1 P40692 L73I 73 L I 0.278 Neutral MLH1 P40692 L73K 73 L K 0.746 Pathogenic MLH1 P40692 L73M 73 L M 0.186 Neutral MLH1 P40692 L73N 73 L N 0.78 Pathogenic MLH1 P40692 L73P 73 L P 0.994 Pathogenic MLH1 P40692 L73Q 73 L Q 0.624 Pathogenic MLH1 P40692 L73R 73 L R 0.996 Pathogenic MLH1 P40692 L73S 73 L S 0.616 Pathogenic MLH1 P40692 L73T 73 L T 0.594 Pathogenic MLH1 P40692 L73V 73 L V 0.578 Pathogenic MLH1 P40692 L73W 73 L W 0.928 Pathogenic MLH1 P40692 L73Y 73 L Y 0.888 Pathogenic MLH1 P40692 P730A 730 P A 0.072 Neutral MLH1 P40692 P730C 730 P C 0.09 Neutral MLH1 P40692 P730D 730 P D 0.118 Neutral MLH1 P40692 P730E 730 P E 0.562 Pathogenic MLH1 P40692 P730F 730 P F 0.97 Pathogenic MLH1 P40692 P730G 730 P G 0.078 Neutral MLH1 P40692 P730H 730 P H 0.868 Pathogenic MLH1 P40692 P730I 730 P I 0.652 Pathogenic MLH1 P40692 P730K 730 P K 0.144 Neutral MLH1 P40692 P730L 730 P L 0.336 Neutral MLH1 P40692 P730M 730 P M 0.754 Pathogenic MLH1 P40692 P730N 730 P N 0.374 Neutral MLH1 P40692 P730Q 730 P Q 0.52 Pathogenic MLH1 P40692 P730R 730 P R 0.526 Pathogenic MLH1 P40692 P730S 730 P S 0.362 Neutral MLH1 P40692 P730T 730 P T 0.432 Neutral MLH1 P40692 P730V 730 P V 0.092 Neutral MLH1 P40692 P730W 730 P W 0.908 Pathogenic MLH1 P40692 P730Y 730 P Y 0.886 Pathogenic MLH1 P40692 P731A 731 P A 0.158 Neutral MLH1 P40692 P731C 731 P C 0.546 Pathogenic MLH1 P40692 P731D 731 P D 0.37 Neutral MLH1 P40692 P731E 731 P E 0.598 Pathogenic MLH1 P40692 P731F 731 P F 0.608 Pathogenic MLH1 P40692 P731G 731 P G 0.282 Neutral MLH1 P40692 P731H 731 P H 0.77 Pathogenic MLH1 P40692 P731I 731 P I 0.678 Pathogenic MLH1 P40692 P731K 731 P K 0.552 Pathogenic MLH1 P40692 P731L 731 P L 0.404 Neutral MLH1 P40692 P731M 731 P M 0.67 Pathogenic MLH1 P40692 P731N 731 P N 0.288 Neutral MLH1 P40692 P731Q 731 P Q 0.63 Pathogenic MLH1 P40692 P731R 731 P R 0.822 Pathogenic MLH1 P40692 P731S 731 P S 0.052 Neutral MLH1 P40692 P731T 731 P T 0.064 Neutral MLH1 P40692 P731V 731 P V 0.532 Pathogenic MLH1 P40692 P731W 731 P W 0.886 Pathogenic MLH1 P40692 P731Y 731 P Y 0.868 Pathogenic MLH1 P40692 K732A 732 K A 0.032 Neutral MLH1 P40692 K732C 732 K C 0.05 Neutral MLH1 P40692 K732D 732 K D 0.094 Neutral MLH1 P40692 K732E 732 K E 0.034 Neutral MLH1 P40692 K732F 732 K F 0.35 Neutral MLH1 P40692 K732G 732 K G 0.176 Neutral MLH1 P40692 K732H 732 K H 0.038 Neutral MLH1 P40692 K732I 732 K I 0.388 Neutral MLH1 P40692 K732L 732 K L 0.368 Neutral MLH1 P40692 K732M 732 K M 0.046 Neutral MLH1 P40692 K732N 732 K N 0.008 Neutral MLH1 P40692 K732P 732 K P 0.03 Neutral MLH1 P40692 K732Q 732 K Q 0.032 Neutral MLH1 P40692 K732R 732 K R 0.006 Neutral MLH1 P40692 K732S 732 K S 0.014 Neutral MLH1 P40692 K732T 732 K T 0.016 Neutral MLH1 P40692 K732V 732 K V 0.168 Neutral MLH1 P40692 K732W 732 K W 0.662 Pathogenic MLH1 P40692 K732Y 732 K Y 0.564 Pathogenic MLH1 P40692 H733A 733 H A 0.07 Neutral MLH1 P40692 H733C 733 H C 0.04 Neutral MLH1 P40692 H733D 733 H D 0.048 Neutral MLH1 P40692 H733E 733 H E 0.002 Neutral MLH1 P40692 H733F 733 H F 0.384 Neutral MLH1 P40692 H733G 733 H G 0.168 Neutral MLH1 P40692 H733I 733 H I 0.398 Neutral MLH1 P40692 H733K 733 H K 0.01 Neutral MLH1 P40692 H733L 733 H L 0.352 Neutral MLH1 P40692 H733M 733 H M 0.218 Neutral MLH1 P40692 H733N 733 H N 0.004 Neutral MLH1 P40692 H733P 733 H P 0.046 Neutral MLH1 P40692 H733Q 733 H Q 0.008 Neutral MLH1 P40692 H733R 733 H R 0.002 Neutral MLH1 P40692 H733S 733 H S 0.016 Neutral MLH1 P40692 H733T 733 H T 0.012 Neutral MLH1 P40692 H733V 733 H V 0.208 Neutral MLH1 P40692 H733W 733 H W 0.644 Pathogenic MLH1 P40692 H733Y 733 H Y 0.042 Neutral MLH1 P40692 F734A 734 F A 0.198 Neutral MLH1 P40692 F734C 734 F C 0.146 Neutral MLH1 P40692 F734D 734 F D 0.41 Neutral MLH1 P40692 F734E 734 F E 0.456 Neutral MLH1 P40692 F734G 734 F G 0.278 Neutral MLH1 P40692 F734H 734 F H 0.18 Neutral MLH1 P40692 F734I 734 F I 0.018 Neutral MLH1 P40692 F734K 734 F K 0.432 Neutral MLH1 P40692 F734L 734 F L 0.01 Neutral MLH1 P40692 F734M 734 F M 0.024 Neutral MLH1 P40692 F734N 734 F N 0.418 Neutral MLH1 P40692 F734P 734 F P 0.468 Neutral MLH1 P40692 F734Q 734 F Q 0.416 Neutral MLH1 P40692 F734R 734 F R 0.45 Neutral MLH1 P40692 F734S 734 F S 0.436 Neutral MLH1 P40692 F734T 734 F T 0.354 Neutral MLH1 P40692 F734V 734 F V 0.036 Neutral MLH1 P40692 F734W 734 F W 0.49 Neutral MLH1 P40692 F734Y 734 F Y 0.302 Neutral MLH1 P40692 T735A 735 T A 0.036 Neutral MLH1 P40692 T735C 735 T C 0.354 Neutral MLH1 P40692 T735D 735 T D 0.442 Neutral MLH1 P40692 T735E 735 T E 0.366 Neutral MLH1 P40692 T735F 735 T F 0.526 Pathogenic MLH1 P40692 T735G 735 T G 0.03 Neutral MLH1 P40692 T735H 735 T H 0.508 Pathogenic MLH1 P40692 T735I 735 T I 0.318 Neutral MLH1 P40692 T735K 735 T K 0.07 Neutral MLH1 P40692 T735L 735 T L 0.062 Neutral MLH1 P40692 T735M 735 T M 0.508 Pathogenic MLH1 P40692 T735N 735 T N 0.178 Neutral MLH1 P40692 T735P 735 T P 0.068 Neutral MLH1 P40692 T735Q 735 T Q 0.186 Neutral MLH1 P40692 T735R 735 T R 0.442 Neutral MLH1 P40692 T735S 735 T S 0.006 Neutral MLH1 P40692 T735V 735 T V 0.062 Neutral MLH1 P40692 T735W 735 T W 0.908 Pathogenic MLH1 P40692 T735Y 735 T Y 0.902 Pathogenic MLH1 P40692 E736A 736 E A 0.17 Neutral MLH1 P40692 E736C 736 E C 0.322 Neutral MLH1 P40692 E736D 736 E D 0.026 Neutral MLH1 P40692 E736F 736 E F 0.696 Pathogenic MLH1 P40692 E736G 736 E G 0.152 Neutral MLH1 P40692 E736H 736 E H 0.05 Neutral MLH1 P40692 E736I 736 E I 0.754 Pathogenic MLH1 P40692 E736K 736 E K 0.042 Neutral MLH1 P40692 E736L 736 E L 0.744 Pathogenic MLH1 P40692 E736M 736 E M 0.56 Pathogenic MLH1 P40692 E736N 736 E N 0.032 Neutral MLH1 P40692 E736P 736 E P 0.2 Neutral MLH1 P40692 E736Q 736 E Q 0.03 Neutral MLH1 P40692 E736R 736 E R 0.066 Neutral MLH1 P40692 E736S 736 E S 0.066 Neutral MLH1 P40692 E736T 736 E T 0.058 Neutral MLH1 P40692 E736V 736 E V 0.73 Pathogenic MLH1 P40692 E736W 736 E W 0.87 Pathogenic MLH1 P40692 E736Y 736 E Y 0.564 Pathogenic MLH1 P40692 D737A 737 D A 0.116 Neutral MLH1 P40692 D737C 737 D C 0.676 Pathogenic MLH1 P40692 D737E 737 D E 0.038 Neutral MLH1 P40692 D737F 737 D F 0.872 Pathogenic MLH1 P40692 D737G 737 D G 0.052 Neutral MLH1 P40692 D737H 737 D H 0.082 Neutral MLH1 P40692 D737I 737 D I 0.834 Pathogenic MLH1 P40692 D737K 737 D K 0.054 Neutral MLH1 P40692 D737L 737 D L 0.828 Pathogenic MLH1 P40692 D737M 737 D M 0.746 Pathogenic MLH1 P40692 D737N 737 D N 0.012 Neutral MLH1 P40692 D737P 737 D P 0.424 Neutral MLH1 P40692 D737Q 737 D Q 0.02 Neutral MLH1 P40692 D737R 737 D R 0.424 Neutral MLH1 P40692 D737S 737 D S 0.01 Neutral MLH1 P40692 D737T 737 D T 0.046 Neutral MLH1 P40692 D737V 737 D V 0.866 Pathogenic MLH1 P40692 D737W 737 D W 0.932 Pathogenic MLH1 P40692 D737Y 737 D Y 0.926 Pathogenic MLH1 P40692 G738A 738 G A 0.292 Neutral MLH1 P40692 G738C 738 G C 0.72 Pathogenic MLH1 P40692 G738D 738 G D 0.83 Pathogenic MLH1 P40692 G738E 738 G E 0.84 Pathogenic MLH1 P40692 G738F 738 G F 0.95 Pathogenic MLH1 P40692 G738H 738 G H 0.974 Pathogenic MLH1 P40692 G738I 738 G I 0.698 Pathogenic MLH1 P40692 G738K 738 G K 0.978 Pathogenic MLH1 P40692 G738L 738 G L 0.616 Pathogenic MLH1 P40692 G738M 738 G M 0.598 Pathogenic MLH1 P40692 G738N 738 G N 0.65 Pathogenic MLH1 P40692 G738P 738 G P 0.93 Pathogenic MLH1 P40692 G738Q 738 G Q 0.744 Pathogenic MLH1 P40692 G738R 738 G R 0.596 Pathogenic MLH1 P40692 G738S 738 G S 0.1 Neutral MLH1 P40692 G738T 738 G T 0.58 Pathogenic MLH1 P40692 G738V 738 G V 0.948 Pathogenic MLH1 P40692 G738W 738 G W 0.964 Pathogenic MLH1 P40692 G738Y 738 G Y 0.958 Pathogenic MLH1 P40692 N739A 739 N A 0.042 Neutral MLH1 P40692 N739C 739 N C 0.316 Neutral MLH1 P40692 N739D 739 N D 0.54 Pathogenic MLH1 P40692 N739E 739 N E 0.436 Neutral MLH1 P40692 N739F 739 N F 0.8 Pathogenic MLH1 P40692 N739G 739 N G 0.55 Pathogenic MLH1 P40692 N739H 739 N H 0.05 Neutral MLH1 P40692 N739I 739 N I 0.514 Pathogenic MLH1 P40692 N739K 739 N K 0.386 Neutral MLH1 P40692 N739L 739 N L 0.142 Neutral MLH1 P40692 N739M 739 N M 0.072 Neutral MLH1 P40692 N739P 739 N P 0.658 Pathogenic MLH1 P40692 N739Q 739 N Q 0.042 Neutral MLH1 P40692 N739R 739 N R 0.542 Pathogenic MLH1 P40692 N739S 739 N S 0.024 Neutral MLH1 P40692 N739T 739 N T 0.024 Neutral MLH1 P40692 N739V 739 N V 0.19 Neutral MLH1 P40692 N739W 739 N W 0.892 Pathogenic MLH1 P40692 N739Y 739 N Y 0.866 Pathogenic MLH1 P40692 D74A 74 D A 0.11 Neutral MLH1 P40692 D74C 74 D C 0.702 Pathogenic MLH1 P40692 D74E 74 D E 0.022 Neutral MLH1 P40692 D74F 74 D F 0.874 Pathogenic MLH1 P40692 D74G 74 D G 0.048 Neutral MLH1 P40692 D74H 74 D H 0.078 Neutral MLH1 P40692 D74I 74 D I 0.838 Pathogenic MLH1 P40692 D74K 74 D K 0.406 Neutral MLH1 P40692 D74L 74 D L 0.83 Pathogenic MLH1 P40692 D74M 74 D M 0.748 Pathogenic MLH1 P40692 D74N 74 D N 0.134 Neutral MLH1 P40692 D74P 74 D P 0.136 Neutral MLH1 P40692 D74Q 74 D Q 0.442 Neutral MLH1 P40692 D74R 74 D R 0.578 Pathogenic MLH1 P40692 D74S 74 D S 0.018 Neutral MLH1 P40692 D74T 74 D T 0.344 Neutral MLH1 P40692 D74V 74 D V 0.564 Pathogenic MLH1 P40692 D74W 74 D W 0.938 Pathogenic MLH1 P40692 D74Y 74 D Y 0.932 Pathogenic MLH1 P40692 I740A 740 I A 0.016 Neutral MLH1 P40692 I740C 740 I C 0.158 Neutral MLH1 P40692 I740D 740 I D 0.044 Neutral MLH1 P40692 I740E 740 I E 0.042 Neutral MLH1 P40692 I740F 740 I F 0.116 Neutral MLH1 P40692 I740G 740 I G 0.3 Neutral MLH1 P40692 I740H 740 I H 0.158 Neutral MLH1 P40692 I740K 740 I K 0.052 Neutral MLH1 P40692 I740L 740 I L 0.004 Neutral MLH1 P40692 I740M 740 I M 0.182 Neutral MLH1 P40692 I740N 740 I N 0.11 Neutral MLH1 P40692 I740P 740 I P 0.27 Neutral MLH1 P40692 I740Q 740 I Q 0.108 Neutral MLH1 P40692 I740R 740 I R 0.418 Neutral MLH1 P40692 I740S 740 I S 0.388 Neutral MLH1 P40692 I740T 740 I T 0.318 Neutral MLH1 P40692 I740V 740 I V 0.004 Neutral MLH1 P40692 I740W 740 I W 0.62 Pathogenic MLH1 P40692 I740Y 740 I Y 0.578 Pathogenic MLH1 P40692 L741A 741 L A 0.042 Neutral MLH1 P40692 L741C 741 L C 0.308 Neutral MLH1 P40692 L741D 741 L D 0.082 Neutral MLH1 P40692 L741E 741 L E 0.084 Neutral MLH1 P40692 L741F 741 L F 0.33 Neutral MLH1 P40692 L741G 741 L G 0.596 Pathogenic MLH1 P40692 L741H 741 L H 0.308 Neutral MLH1 P40692 L741I 741 L I 0.03 Neutral MLH1 P40692 L741K 741 L K 0.092 Neutral MLH1 P40692 L741M 741 L M 0.452 Neutral MLH1 P40692 L741N 741 L N 0.152 Neutral MLH1 P40692 L741P 741 L P 0.812 Pathogenic MLH1 P40692 L741Q 741 L Q 0.298 Neutral MLH1 P40692 L741R 741 L R 0.5 Pathogenic MLH1 P40692 L741S 741 L S 0.288 Neutral MLH1 P40692 L741T 741 L T 0.042 Neutral MLH1 P40692 L741V 741 L V 0.006 Neutral MLH1 P40692 L741W 741 L W 0.812 Pathogenic MLH1 P40692 L741Y 741 L Y 0.562 Pathogenic MLH1 P40692 Q742A 742 Q A 0.218 Neutral MLH1 P40692 Q742C 742 Q C 0.396 Neutral MLH1 P40692 Q742D 742 Q D 0.03 Neutral MLH1 P40692 Q742E 742 Q E 0.022 Neutral MLH1 P40692 Q742F 742 Q F 0.758 Pathogenic MLH1 P40692 Q742G 742 Q G 0.09 Neutral MLH1 P40692 Q742H 742 Q H 0.788 Pathogenic MLH1 P40692 Q742I 742 Q I 0.4 Neutral MLH1 P40692 Q742K 742 Q K 0.044 Neutral MLH1 P40692 Q742L 742 Q L 0.466 Neutral MLH1 P40692 Q742M 742 Q M 0.664 Pathogenic MLH1 P40692 Q742N 742 Q N 0.076 Neutral MLH1 P40692 Q742P 742 Q P 0.816 Pathogenic MLH1 P40692 Q742R 742 Q R 0.036 Neutral MLH1 P40692 Q742S 742 Q S 0.39 Neutral MLH1 P40692 Q742T 742 Q T 0.502 Pathogenic MLH1 P40692 Q742V 742 Q V 0.788 Pathogenic MLH1 P40692 Q742W 742 Q W 0.886 Pathogenic MLH1 P40692 Q742Y 742 Q Y 0.836 Pathogenic MLH1 P40692 L743A 743 L A 0.016 Neutral MLH1 P40692 L743C 743 L C 0.164 Neutral MLH1 P40692 L743D 743 L D 0.314 Neutral MLH1 P40692 L743E 743 L E 0.042 Neutral MLH1 P40692 L743F 743 L F 0.452 Neutral MLH1 P40692 L743G 743 L G 0.066 Neutral MLH1 P40692 L743H 743 L H 0.064 Neutral MLH1 P40692 L743I 743 L I 0.01 Neutral MLH1 P40692 L743K 743 L K 0.032 Neutral MLH1 P40692 L743M 743 L M 0.262 Neutral MLH1 P40692 L743N 743 L N 0.302 Neutral MLH1 P40692 L743P 743 L P 0.412 Neutral MLH1 P40692 L743Q 743 L Q 0.124 Neutral MLH1 P40692 L743R 743 L R 0.592 Pathogenic MLH1 P40692 L743S 743 L S 0.142 Neutral MLH1 P40692 L743T 743 L T 0.234 Neutral MLH1 P40692 L743V 743 L V 0.006 Neutral MLH1 P40692 L743W 743 L W 0.626 Pathogenic MLH1 P40692 L743Y 743 L Y 0.584 Pathogenic MLH1 P40692 A744C 744 A C 0.954 Pathogenic MLH1 P40692 A744D 744 A D 0.946 Pathogenic MLH1 P40692 A744E 744 A E 0.962 Pathogenic MLH1 P40692 A744F 744 A F 0.986 Pathogenic MLH1 P40692 A744G 744 A G 0.73 Pathogenic MLH1 P40692 A744H 744 A H 0.804 Pathogenic MLH1 P40692 A744I 744 A I 0.928 Pathogenic MLH1 P40692 A744K 744 A K 0.964 Pathogenic MLH1 P40692 A744L 744 A L 0.992 Pathogenic MLH1 P40692 A744M 744 A M 0.898 Pathogenic MLH1 P40692 A744N 744 A N 0.864 Pathogenic MLH1 P40692 A744P 744 A P 0.958 Pathogenic MLH1 P40692 A744Q 744 A Q 0.88 Pathogenic MLH1 P40692 A744R 744 A R 0.658 Pathogenic MLH1 P40692 A744S 744 A S 0.544 Pathogenic MLH1 P40692 A744T 744 A T 0.18 Neutral MLH1 P40692 A744V 744 A V 0.534 Pathogenic MLH1 P40692 A744W 744 A W 0.988 Pathogenic MLH1 P40692 A744Y 744 A Y 0.962 Pathogenic MLH1 P40692 N745A 745 N A 0.268 Neutral MLH1 P40692 N745C 745 N C 0.078 Neutral MLH1 P40692 N745D 745 N D 0.046 Neutral MLH1 P40692 N745E 745 N E 0.454 Neutral MLH1 P40692 N745F 745 N F 0.878 Pathogenic MLH1 P40692 N745G 745 N G 0.13 Neutral MLH1 P40692 N745H 745 N H 0.698 Pathogenic MLH1 P40692 N745I 745 N I 0.842 Pathogenic MLH1 P40692 N745K 745 N K 0.76 Pathogenic MLH1 P40692 N745L 745 N L 0.822 Pathogenic MLH1 P40692 N745M 745 N M 0.804 Pathogenic MLH1 P40692 N745P 745 N P 0.696 Pathogenic MLH1 P40692 N745Q 745 N Q 0.592 Pathogenic MLH1 P40692 N745R 745 N R 0.76 Pathogenic MLH1 P40692 N745S 745 N S 0.056 Neutral MLH1 P40692 N745T 745 N T 0.45 Neutral MLH1 P40692 N745V 745 N V 0.872 Pathogenic MLH1 P40692 N745W 745 N W 0.916 Pathogenic MLH1 P40692 N745Y 745 N Y 0.904 Pathogenic MLH1 P40692 L746A 746 L A 0.704 Pathogenic MLH1 P40692 L746C 746 L C 0.82 Pathogenic MLH1 P40692 L746D 746 L D 0.888 Pathogenic MLH1 P40692 L746E 746 L E 0.868 Pathogenic MLH1 P40692 L746F 746 L F 0.904 Pathogenic MLH1 P40692 L746G 746 L G 0.826 Pathogenic MLH1 P40692 L746H 746 L H 0.908 Pathogenic MLH1 P40692 L746I 746 L I 0.936 Pathogenic MLH1 P40692 L746K 746 L K 0.382 Neutral MLH1 P40692 L746M 746 L M 0.356 Neutral MLH1 P40692 L746N 746 L N 0.188 Neutral MLH1 P40692 L746P 746 L P 0.994 Pathogenic MLH1 P40692 L746Q 746 L Q 0.732 Pathogenic MLH1 P40692 L746R 746 L R 0.978 Pathogenic MLH1 P40692 L746S 746 L S 0.644 Pathogenic MLH1 P40692 L746T 746 L T 0.278 Neutral MLH1 P40692 L746V 746 L V 0.47 Neutral MLH1 P40692 L746W 746 L W 0.892 Pathogenic MLH1 P40692 L746Y 746 L Y 0.88 Pathogenic MLH1 P40692 P747A 747 P A 0.454 Neutral MLH1 P40692 P747C 747 P C 0.656 Pathogenic MLH1 P40692 P747D 747 P D 0.12 Neutral MLH1 P40692 P747E 747 P E 0.15 Neutral MLH1 P40692 P747F 747 P F 0.65 Pathogenic MLH1 P40692 P747G 747 P G 0.32 Neutral MLH1 P40692 P747H 747 P H 0.746 Pathogenic MLH1 P40692 P747I 747 P I 0.772 Pathogenic MLH1 P40692 P747K 747 P K 0.138 Neutral MLH1 P40692 P747L 747 P L 0.596 Pathogenic MLH1 P40692 P747M 747 P M 0.746 Pathogenic MLH1 P40692 P747N 747 P N 0.056 Neutral MLH1 P40692 P747Q 747 P Q 0.278 Neutral MLH1 P40692 P747R 747 P R 0.524 Pathogenic MLH1 P40692 P747S 747 P S 0.056 Neutral MLH1 P40692 P747T 747 P T 0.04 Neutral MLH1 P40692 P747V 747 P V 0.634 Pathogenic MLH1 P40692 P747W 747 P W 0.894 Pathogenic MLH1 P40692 P747Y 747 P Y 0.87 Pathogenic MLH1 P40692 D748A 748 D A 0.126 Neutral MLH1 P40692 D748C 748 D C 0.732 Pathogenic MLH1 P40692 D748E 748 D E 0.042 Neutral MLH1 P40692 D748F 748 D F 0.928 Pathogenic MLH1 P40692 D748G 748 D G 0.066 Neutral MLH1 P40692 D748H 748 D H 0.444 Neutral MLH1 P40692 D748I 748 D I 0.84 Pathogenic MLH1 P40692 D748K 748 D K 0.068 Neutral MLH1 P40692 D748L 748 D L 0.89 Pathogenic MLH1 P40692 D748M 748 D M 0.804 Pathogenic MLH1 P40692 D748N 748 D N 0.012 Neutral MLH1 P40692 D748P 748 D P 0.758 Pathogenic MLH1 P40692 D748Q 748 D Q 0.466 Neutral MLH1 P40692 D748R 748 D R 0.51 Pathogenic MLH1 P40692 D748S 748 D S 0.024 Neutral MLH1 P40692 D748T 748 D T 0.076 Neutral MLH1 P40692 D748V 748 D V 0.916 Pathogenic MLH1 P40692 D748W 748 D W 0.97 Pathogenic MLH1 P40692 D748Y 748 D Y 0.964 Pathogenic MLH1 P40692 L749A 749 L A 0.294 Neutral MLH1 P40692 L749C 749 L C 0.82 Pathogenic MLH1 P40692 L749D 749 L D 0.888 Pathogenic MLH1 P40692 L749E 749 L E 0.868 Pathogenic MLH1 P40692 L749F 749 L F 0.904 Pathogenic MLH1 P40692 L749G 749 L G 0.828 Pathogenic MLH1 P40692 L749H 749 L H 0.908 Pathogenic MLH1 P40692 L749I 749 L I 0.936 Pathogenic MLH1 P40692 L749K 749 L K 0.724 Pathogenic MLH1 P40692 L749M 749 L M 0.356 Neutral MLH1 P40692 L749N 749 L N 0.474 Neutral MLH1 P40692 L749P 749 L P 0.994 Pathogenic 5 MLH1 P40692 L749Q 749 L Q 0.732 Pathogenic MLH1 P40692 L749R 749 L R 0.978 Pathogenic MLH1 P40692 L749S 749 L S 0.646 Pathogenic MLH1 P40692 L749T 749 L T 0.602 Pathogenic MLH1 P40692 L749V 749 L V 0.47 Neutral MLH1 P40692 L749W 749 L W 0.892 Pathogenic MLH1 P40692 L749Y 749 L Y 0.66 Pathogenic MLH1 P40692 I75A 75 I A 0.462 Neutral MLH1 P40692 I75C 75 I C 0.206 Neutral MLH1 P40692 I75D 75 I D 0.744 Pathogenic MLH1 P40692 I75E 75 I E 0.754 Pathogenic MLH1 P40692 I75F 75 I F 0.962 Pathogenic MLH1 P40692 I75G 75 I G 0.792 Pathogenic MLH1 P40692 I75H 75 I H 0.848 Pathogenic MLH1 P40692 I75K 75 I K 0.846 Pathogenic MLH1 P40692 I75L 75 I L 0.082 Neutral MLH1 P40692 I75M 75 I M 0.688 Pathogenic MLH1 P40692 I75N 75 I N 0.77 Pathogenic MLH1 P40692 I75P 75 I P 0.926 Pathogenic MLH1 P40692 I75Q 75 I Q 0.784 Pathogenic MLH1 P40692 I75R 75 I R 0.874 Pathogenic MLH1 P40692 I75S 75 I S 0.61 Pathogenic MLH1 P40692 I75T 75 I T 0.332 Neutral MLH1 P40692 I75V 75 I V 0.198 Neutral MLH1 P40692 I75W 75 I W 0.986 Pathogenic MLH1 P40692 I75Y 75 I Y 0.976 Pathogenic MLH1 P40692 Y750A 750 Y A 0.424 Neutral MLH1 P40692 Y750C 750 Y C 0.66 Pathogenic MLH1 P40692 Y750D 750 Y D 0.808 Pathogenic MLH1 P40692 Y750E 750 Y E 0.712 Pathogenic MLH1 P40692 Y750F 750 Y F 0.186 Neutral MLH1 P40692 Y750G 750 Y G 0.298 Neutral MLH1 P40692 Y750H 750 Y H 0.592 Pathogenic MLH1 P40692 Y750I 750 Y I 0.804 Pathogenic MLH1 P40692 Y750K 750 Y K 0.818 Pathogenic MLH1 P40692 Y750L 750 Y L 0.278 Neutral MLH1 P40692 Y750M 750 Y M 0.676 Pathogenic MLH1 P40692 Y750N 750 Y N 0.706 Pathogenic MLH1 P40692 Y750P 750 Y P 0.794 Pathogenic MLH1 P40692 Y750Q 750 Y Q 0.616 Pathogenic MLH1 P40692 Y750R 750 Y R 0.732 Pathogenic MLH1 P40692 Y750S 750 Y S 0.474 Neutral MLH1 P40692 Y750T 750 Y T 0.656 Pathogenic MLH1 P40692 Y750V 750 Y V 0.744 Pathogenic MLH1 P40692 Y750W 750 Y W 0.91 Pathogenic MLH1 P40692 K751A 751 K A 0.538 Pathogenic MLH1 P40692 K751C 751 K C 0.444 Neutral MLH1 P40692 K751D 751 K D 0.616 Pathogenic MLH1 P40692 K751E 751 K E 0.714 Pathogenic MLH1 P40692 K751F 751 K F 0.948 Pathogenic MLH1 P40692 K751G 751 K G 0.542 Pathogenic MLH1 P40692 K751H 751 K H 0.246 Neutral MLH1 P40692 K751I 751 K I 0.984 Pathogenic MLH1 P40692 K751L 751 K L 0.682 Pathogenic MLH1 P40692 K751M 751 K M 0.898 Pathogenic MLH1 P40692 K751N 751 K N 0.668 Pathogenic MLH1 P40692 K751P 751 K P 0.908 Pathogenic MLH1 P40692 K751Q 751 K Q 0.728 Pathogenic MLH1 P40692 K751R 751 K R 0.092 Neutral 2 MLH1 P40692 K751S 751 K S 0.356 Neutral MLH1 P40692 K751T 751 K T 0.29 Neutral MLH1 P40692 K751V 751 K V 0.866 Pathogenic MLH1 P40692 K751W 751 K W 0.99 Pathogenic MLH1 P40692 K751Y 751 K Y 0.562 Pathogenic MLH1 P40692 V752A 752 V A 0.38 Neutral MLH1 P40692 V752C 752 V C 0.766 Pathogenic MLH1 P40692 V752D 752 V D 0.854 Pathogenic MLH1 P40692 V752E 752 V E 0.968 Pathogenic MLH1 P40692 V752F 752 V F 0.9 Pathogenic MLH1 P40692 V752G 752 V G 0.888 Pathogenic MLH1 P40692 V752H 752 V H 0.864 Pathogenic MLH1 P40692 V752I 752 V I 0.216 Neutral MLH1 P40692 V752K 752 V K 0.71 Pathogenic MLH1 P40692 V752L 752 V L 0.894 Pathogenic MLH1 P40692 V752M 752 V M 0.87 Pathogenic MLH1 P40692 V752N 752 V N 0.916 Pathogenic MLH1 P40692 V752P 752 V P 0.728 Pathogenic MLH1 P40692 V752Q 752 V Q 0.976 Pathogenic MLH1 P40692 V752R 752 V R 0.95 Pathogenic MLH1 P40692 V752S 752 V S 0.764 Pathogenic MLH1 P40692 V752T 752 V T 0.834 Pathogenic MLH1 P40692 V752W 752 V W 0.924 Pathogenic MLH1 P40692 V752Y 752 V Y 0.952 Pathogenic MLH1 P40692 F753A 753 F A 0.512 Pathogenic MLH1 P40692 F753C 753 F C 0.72 Pathogenic MLH1 P40692 F753D 753 F D 0.804 Pathogenic MLH1 P40692 F753E 753 F E 0.852 Pathogenic MLH1 P40692 F753G 753 F G 0.512 Pathogenic MLH1 P40692 F753H 753 F H 0.762 Pathogenic MLH1 P40692 F753I 753 F I 0.678 Pathogenic MLH1 P40692 F753K 753 F K 0.84 Pathogenic MLH1 P40692 F753L 753 F L 0.244 Neutral MLH1 P40692 F753M 753 F M 0.782 Pathogenic MLH1 P40692 F753N 753 F N 0.742 Pathogenic MLH1 P40692 F753P 753 F P 0.966 Pathogenic MLH1 P40692 F753Q 753 F Q 0.754 Pathogenic MLH1 P40692 F753R 753 F R 0.532 Pathogenic MLH1 P40692 F753S 753 F S 0.864 Pathogenic MLH1 P40692 F753T 753 F T 0.592 Pathogenic MLH1 P40692 F753V 753 F V 0.792 Pathogenic MLH1 P40692 F753W 753 F W 0.868 Pathogenic MLH1 P40692 F753Y 753 F Y 0.59 Pathogenic MLH1 P40692 E754A 754 E A 0.812 Pathogenic MLH1 P40692 E754C 754 E C 0.758 Pathogenic MLH1 P40692 E754D 754 E D 0.892 Pathogenic MLH1 P40692 E754F 754 E F 0.83 Pathogenic MLH1 P40692 E754G 754 E G 0.382 Neutral MLH1 P40692 E754H 754 E H 0.778 Pathogenic MLH1 P40692 E754I 754 E I 0.98 Pathogenic MLH1 P40692 E754K 754 E K 0.66 Pathogenic MLH1 P40692 E754L 754 E L 0.972 Pathogenic MLH1 P40692 E754M 754 E M 0.91 Pathogenic MLH1 P40692 E754N 754 E N 0.77 Pathogenic MLH1 P40692 E754P 754 E P 0.934 Pathogenic MLH1 P40692 E754Q 754 E Q 0.85 Pathogenic MLH1 P40692 E754R 754 E R 0.93 Pathogenic MLH1 P40692 E754S 754 E S 0.898 Pathogenic MLH1 P40692 E754T 754 E T 0.86 Pathogenic MLH1 P40692 E754V 754 E V 0.916 Pathogenic MLH1 P40692 E754W 754 E W 0.978 Pathogenic MLH1 P40692 E754Y 754 E Y 0.958 Pathogenic MLH1 P40692 R755A 755 R A 0.582 Pathogenic MLH1 P40692 R755C 755 R C 0.964 Pathogenic MLH1 P40692 R755D 755 R D 0.708 Pathogenic MLH1 P40692 R755E 755 R E 0.788 Pathogenic MLH1 P40692 R755F 755 R F 0.968 Pathogenic MLH1 P40692 R755G 755 R G 0.434 Neutral MLH1 P40692 R755H 755 R H 0.366 Neutral MLH1 P40692 R755I 755 R I 0.976 Pathogenic MLH1 P40692 R755K 755 R K 0.752 Pathogenic MLH1 P40692 R755L 755 R L 0.986 Pathogenic MLH1 P40692 R755M 755 R M 0.77 Pathogenic MLH1 P40692 R755N 755 R N 0.66 Pathogenic MLH1 P40692 R755P 755 R P 0.986 Pathogenic MLH1 P40692 R755Q 755 R Q 0.508 Pathogenic MLH1 P40692 R755S 755 R S 0.936 Pathogenic 4 MLH1 P40692 R755T 755 R T 0.946 Pathogenic MLH1 P40692 R755V 755 R V 0.978 Pathogenic MLH1 P40692 R755W 755 R W 0.954 Pathogenic MLH1 P40692 R755Y 755 R Y 0.958 Pathogenic MLH1 P40692 C756A 756 C A 0.728 Pathogenic MLH1 P40692 C756D 756 C D 0.95 Pathogenic MLH1 P40692 C756E 756 C E 0.51 Pathogenic MLH1 P40692 C756F 756 C F 0.974 Pathogenic MLH1 P40692 C756G 756 C G 0.938 Pathogenic MLH1 P40692 C756H 756 C H 0.83 Pathogenic MLH1 P40692 C756I 756 C I 0.96 Pathogenic MLH1 P40692 C756K 756 C K 0.888 Pathogenic MLH1 P40692 C756L 756 C L 0.974 Pathogenic MLH1 P40692 C756M 756 C M 0.748 Pathogenic MLH1 P40692 C756N 756 C N 0.814 Pathogenic MLH1 P40692 C756P 756 C P 0.976 Pathogenic MLH1 P40692 C756Q 756 C Q 0.65 Pathogenic MLH1 P40692 C756R 756 C R 1 Pathogenic MLH1 P40692 C756S 756 C S 0.536 Pathogenic MLH1 P40692 C756T 756 C T 0.712 Pathogenic MLH1 P40692 C756V 756 C V 0.96 Pathogenic MLH1 P40692 C756W 756 C W 0.984 Pathogenic MLH1 P40692 C756Y 756 C Y 0.97 Pathogenic MLH1 P40692 V76A 76 V A 0.128 Neutral MLH1 P40692 V76C 76 V C 0.702 Pathogenic MLH1 P40692 V76D 76 V D 0.864 Pathogenic MLH1 P40692 V76E 76 V E 0.316 Neutral MLH1 P40692 V76F 76 V F 0.866 Pathogenic MLH1 P40692 V76G 76 V G 0.906 Pathogenic MLH1 P40692 V76H 76 V H 0.806 Pathogenic MLH1 P40692 V76I 76 V I 0.24 Neutral MLH1 P40692 V76K 76 V K 0.968 Pathogenic MLH1 P40692 V76L 76 V L 0.25 Neutral MLH1 P40692 V76M 76 V M 0.8 Pathogenic MLH1 P40692 V76N 76 V N 0.932 Pathogenic MLH1 P40692 V76P 76 V P 0.966 Pathogenic MLH1 P40692 V76Q 76 V Q 0.99 Pathogenic MLH1 P40692 V76R 76 V R 0.958 Pathogenic MLH1 P40692 V76S 76 V S 0.74 Pathogenic MLH1 P40692 V76T 76 V T 0.736 Pathogenic MLH1 P40692 V76W 76 V W 0.898 Pathogenic MLH1 P40692 V76Y 76 V Y 0.922 Pathogenic MLH1 P40692 C77A 77 C A 0.134 Neutral MLH1 P40692 C77D 77 C D 0.93 Pathogenic MLH1 P40692 C77E 77 C E 0.904 Pathogenic MLH1 P40692 C77F 77 C F 0.996 Pathogenic MLH1 P40692 C77G 77 C G 0.91 Pathogenic MLH1 P40692 C77H 77 C H 0.888 Pathogenic MLH1 P40692 C77I 77 C I 0.962 Pathogenic MLH1 P40692 C77K 77 C K 0.898 Pathogenic MLH1 P40692 C77L 77 C L 0.99 Pathogenic MLH1 P40692 C77M 77 C M 0.81 Pathogenic MLH1 P40692 C77N 77 C N 0.756 Pathogenic MLH1 P40692 C77P 77 C P 0.976 Pathogenic MLH1 P40692 C77Q 77 C Q 0.404 Neutral MLH1 P40692 C77R 77 C R 0.672 Pathogenic 5 MLH1 P40692 C77S 77 C S 0.602 Pathogenic MLH1 P40692 C77T 77 C T 0.784 Pathogenic MLH1 P40692 C77V 77 C V 0.738 Pathogenic MLH1 P40692 C77W 77 C W 0.996 Pathogenic MLH1 P40692 C77Y 77 C Y 0.992 Pathogenic 5 MLH1 P40692 E78A 78 E A 0.746 Pathogenic MLH1 P40692 E78C 78 E C 0.682 Pathogenic MLH1 P40692 E78D 78 E D 0.334 Neutral MLH1 P40692 E78F 78 E F 0.598 Pathogenic MLH1 P40692 E78G 78 E G 0.368 Neutral MLH1 P40692 E78H 78 E H 0.692 Pathogenic MLH1 P40692 E78I 78 E I 0.8 Pathogenic MLH1 P40692 E78K 78 E K 0.942 Pathogenic MLH1 P40692 E78L 78 E L 0.954 Pathogenic MLH1 P40692 E78M 78 E M 0.892 Pathogenic MLH1 P40692 E78N 78 E N 0.676 Pathogenic MLH1 P40692 E78P 78 E P 0.916 Pathogenic MLH1 P40692 E78Q 78 E Q 0.134 Neutral MLH1 P40692 E78R 78 E R 0.874 Pathogenic MLH1 P40692 E78S 78 E S 0.858 Pathogenic MLH1 P40692 E78T 78 E T 0.41 Neutral MLH1 P40692 E78V 78 E V 0.46 Neutral MLH1 P40692 E78W 78 E W 0.978 Pathogenic MLH1 P40692 E78Y 78 E Y 0.958 Pathogenic MLH1 P40692 R79A 79 R A 0.586 Pathogenic MLH1 P40692 R79C 79 R C 0.966 Pathogenic MLH1 P40692 R79D 79 R D 0.792 Pathogenic MLH1 P40692 R79E 79 R E 0.82 Pathogenic MLH1 P40692 R79F 79 R F 0.976 Pathogenic MLH1 P40692 R79G 79 R G 0.438 Neutral MLH1 P40692 R79H 79 R H 0.466 Neutral MLH1 P40692 R79I 79 R I 0.978 Pathogenic MLH1 P40692 R79K 79 R K 0.538 Pathogenic MLH1 P40692 R79L 79 R L 0.99 Pathogenic MLH1 P40692 R79M 79 R M 0.788 Pathogenic MLH1 P40692 R79N 79 R N 0.716 Pathogenic MLH1 P40692 R79P 79 R P 0.99 Pathogenic MLH1 P40692 R79Q 79 R Q 0.27 Neutral MLH1 P40692 R79S 79 R S 0.934 Pathogenic MLH1 P40692 R79T 79 R T 0.224 Neutral MLH1 P40692 R79V 79 R V 0.98 Pathogenic MLH1 P40692 R79W 79 R W 0.968 Pathogenic MLH1 P40692 R79Y 79 R Y 0.974 Pathogenic MLH1 P40692 I8A 8 I A 0.466 Neutral MLH1 P40692 I8C 8 I C 0.604 Pathogenic MLH1 P40692 I8D 8 I D 0.754 Pathogenic MLH1 P40692 I8E 8 I E 0.76 Pathogenic MLH1 P40692 I8F 8 I F 0.962 Pathogenic MLH1 P40692 I8G 8 I G 0.804 Pathogenic MLH1 P40692 I8H 8 I H 0.838 Pathogenic MLH1 P40692 I8K 8 I K 0.848 Pathogenic MLH1 P40692 I8L 8 I L 0.726 Pathogenic MLH1 P40692 I8M 8 I M 0.406 Neutral MLH1 P40692 I8N 8 I N 0.78 Pathogenic MLH1 P40692 I8P 8 I P 0.94 Pathogenic MLH1 P40692 I8Q 8 I Q 0.792 Pathogenic MLH1 P40692 I8R 8 I R 0.876 Pathogenic MLH1 P40692 I8S 8 I S 0.622 Pathogenic MLH1 P40692 I8T 8 I T 0.344 Neutral MLH1 P40692 I8V 8 I V 0.15 Neutral MLH1 P40692 I8W 8 I W 0.986 Pathogenic MLH1 P40692 I8Y 8 I Y 0.978 Pathogenic MLH1 P40692 F80A 80 F A 0.418 Neutral MLH1 P40692 F80C 80 F C 0.58 Pathogenic MLH1 P40692 F80D 80 F D 0.424 Neutral MLH1 P40692 F80E 80 F E 0.824 Pathogenic MLH1 P40692 F80G 80 F G 0.468 Neutral MLH1 P40692 F80H 80 F H 0.112 Neutral MLH1 P40692 F80I 80 F I 0.562 Pathogenic MLH1 P40692 F80K 80 F K 0.806 Pathogenic MLH1 P40692 F80L 80 F L 0.548 Pathogenic MLH1 P40692 F80M 80 F M 0.648 Pathogenic MLH1 P40692 F80N 80 F N 0.672 Pathogenic MLH1 P40692 F80P 80 F P 0.93 Pathogenic MLH1 P40692 F80Q 80 F Q 0.694 Pathogenic MLH1 P40692 F80R 80 F R 0.888 Pathogenic MLH1 P40692 F80S 80 F S 0.762 Pathogenic MLH1 P40692 F80T 80 F T 0.218 Neutral MLH1 P40692 F80V 80 F V 0.836 Pathogenic 5 MLH1 P40692 F80W 80 F W 0.938 Pathogenic MLH1 P40692 F80Y 80 F Y 0.328 Neutral MLH1 P40692 T81A 81 T A 0.156 Neutral MLH1 P40692 T81C 81 T C 0.872 Pathogenic MLH1 P40692 T81D 81 T D 0.882 Pathogenic MLH1 P40692 T81E 81 T E 0.922 Pathogenic MLH1 P40692 T81F 81 T F 0.928 Pathogenic MLH1 P40692 T81G 81 T G 0.636 Pathogenic MLH1 P40692 T81H 81 T H 0.878 Pathogenic MLH1 P40692 T81I 81 T I 0.914 Pathogenic MLH1 P40692 T81K 81 T K 0.898 Pathogenic MLH1 P40692 T81L 81 T L 0.902 Pathogenic MLH1 P40692 T81M 81 T M 0.97 Pathogenic MLH1 P40692 T81N 81 T N 0.326 Neutral MLH1 P40692 T81P 81 T P 0.926 Pathogenic MLH1 P40692 T81Q 81 T Q 0.822 Pathogenic MLH1 P40692 T81R 81 T R 0.962 Pathogenic MLH1 P40692 T81S 81 T S 0.14 Neutral MLH1 P40692 T81V 81 T V 0.868 Pathogenic MLH1 P40692 T81W 81 T W 0.986 Pathogenic MLH1 P40692 T81Y 81 T Y 0.986 Pathogenic MLH1 P40692 T82A 82 T A 0.706 Pathogenic 4 MLH1 P40692 T82C 82 T C 0.938 Pathogenic MLH1 P40692 T82D 82 T D 0.948 Pathogenic MLH1 P40692 T82E 82 T E 0.946 Pathogenic MLH1 P40692 T82F 82 T F 0.95 Pathogenic MLH1 P40692 T82G 82 T G 0.276 Neutral MLH1 P40692 T82H 82 T H 0.918 Pathogenic MLH1 P40692 T82I 82 T I 0.952 Pathogenic 5 MLH1 P40692 T82K 82 T K 0.524 Pathogenic MLH1 P40692 T82L 82 T L 0.95 Pathogenic MLH1 P40692 T82M 82 T M 0.98 Pathogenic MLH1 P40692 T82N 82 T N 0.888 Pathogenic MLH1 P40692 T82P 82 T P 0.962 Pathogenic MLH1 P40692 T82Q 82 T Q 0.884 Pathogenic MLH1 P40692 T82R 82 T R 0.994 Pathogenic MLH1 P40692 T82S 82 T S 0.824 Pathogenic MLH1 P40692 T82V 82 T V 0.856 Pathogenic MLH1 P40692 T82W 82 T W 0.974 Pathogenic MLH1 P40692 T82Y 82 T Y 0.974 Pathogenic MLH1 P40692 S83A 83 S A 0.862 Pathogenic MLH1 P40692 S83C 83 S C 0.9 Pathogenic MLH1 P40692 S83D 83 S D 0.904 Pathogenic MLH1 P40692 S83E 83 S E 0.958 Pathogenic MLH1 P40692 S83F 83 S F 0.982 Pathogenic MLH1 P40692 S83G 83 S G 0.688 Pathogenic MLH1 P40692 S83H 83 S H 0.974 Pathogenic MLH1 P40692 S83I 83 S I 0.884 Pathogenic MLH1 P40692 S83K 83 S K 0.954 Pathogenic MLH1 P40692 S83L 83 S L 0.592 Pathogenic MLH1 P40692 S83M 83 S M 0.998 Pathogenic MLH1 P40692 S83N 83 S N 0.888 Pathogenic MLH1 P40692 S83P 83 S P 0.97 Pathogenic MLH1 P40692 S83Q 83 S Q 0.948 Pathogenic MLH1 P40692 S83R 83 S R 0.972 Pathogenic MLH1 P40692 S83T 83 S T 0.644 Pathogenic MLH1 P40692 S83V 83 S V 0.958 Pathogenic MLH1 P40692 S83W 83 S W 0.952 Pathogenic MLH1 P40692 S83Y 83 S Y 0.96 Pathogenic MLH1 P40692 K84A 84 K A 0.7 Pathogenic MLH1 P40692 K84C 84 K C 0.58 Pathogenic MLH1 P40692 K84D 84 K D 0.766 Pathogenic MLH1 P40692 K84E 84 K E 0.874 Pathogenic 4 MLH1 P40692 K84F 84 K F 0.968 Pathogenic MLH1 P40692 K84G 84 K G 0.312 Neutral MLH1 P40692 K84H 84 K H 0.876 Pathogenic MLH1 P40692 K84I 84 K I 0.992 Pathogenic MLH1 P40692 K84L 84 K L 0.984 Pathogenic MLH1 P40692 K84M 84 K M 0.894 Pathogenic MLH1 P40692 K84N 84 K N 0.786 Pathogenic MLH1 P40692 K84P 84 K P 0.924 Pathogenic MLH1 P40692 K84Q 84 K Q 0.39 Neutral MLH1 P40692 K84R 84 K R 0.392 Neutral MLH1 P40692 K84S 84 K S 0.668 Pathogenic MLH1 P40692 K84T 84 K T 0.656 Pathogenic MLH1 P40692 K84V 84 K V 0.884 Pathogenic MLH1 P40692 K84W 84 K W 0.986 Pathogenic MLH1 P40692 K84Y 84 K Y 0.978 Pathogenic MLH1 P40692 L85A 85 L A 0.634 Pathogenic MLH1 P40692 L85C 85 L C 0.76 Pathogenic MLH1 P40692 L85D 85 L D 0.884 Pathogenic MLH1 P40692 L85E 85 L E 0.864 Pathogenic MLH1 P40692 L85F 85 L F 0.98 Pathogenic MLH1 P40692 L85G 85 L G 0.796 Pathogenic MLH1 P40692 L85H 85 L H 0.876 Pathogenic MLH1 P40692 L85I 85 L I 0.22 Neutral MLH1 P40692 L85K 85 L K 0.442 Neutral MLH1 P40692 L85M 85 L M 0.744 Pathogenic MLH1 P40692 L85N 85 L N 0.748 Pathogenic MLH1 P40692 L85P 85 L P 0.99 Pathogenic MLH1 P40692 L85Q 85 L Q 0.686 Pathogenic MLH1 P40692 L85R 85 L R 0.984 Pathogenic MLH1 P40692 L85S 85 L S 0.63 Pathogenic MLH1 P40692 L85T 85 L T 0.328 Neutral MLH1 P40692 L85V 85 L V 0.562 Pathogenic MLH1 P40692 L85W 85 L W 0.942 Pathogenic MLH1 P40692 L85Y 85 L Y 0.904 Pathogenic MLH1 P40692 Q86A 86 Q A 0.184 Neutral MLH1 P40692 Q86C 86 Q C 0.38 Neutral MLH1 P40692 Q86D 86 Q D 0.452 Neutral MLH1 P40692 Q86E 86 Q E 0.056 Neutral MLH1 P40692 Q86F 86 Q F 0.85 Pathogenic MLH1 P40692 Q86G 86 Q G 0.484 Neutral MLH1 P40692 Q86H 86 Q H 0.75 Pathogenic MLH1 P40692 Q86I 86 Q I 0.826 Pathogenic MLH1 P40692 Q86K 86 Q K 0.068 Neutral MLH1 P40692 Q86L 86 Q L 0.72 Pathogenic MLH1 P40692 Q86M 86 Q M 0.682 Pathogenic MLH1 P40692 Q86N 86 Q N 0.416 Neutral MLH1 P40692 Q86P 86 Q P 0.838 Pathogenic MLH1 P40692 Q86R 86 Q R 0.082 Neutral MLH1 P40692 Q86S 86 Q S 0.1 Neutral MLH1 P40692 Q86T 86 Q T 0.046 Neutral MLH1 P40692 Q86V 86 Q V 0.78 Pathogenic MLH1 P40692 Q86W 86 Q W 0.9 Pathogenic MLH1 P40692 Q86Y 86 Q Y 0.908 Pathogenic MLH1 P40692 S87A 87 S A 0.034 Neutral MLH1 P40692 S87C 87 S C 0.348 Neutral MLH1 P40692 S87D 87 S D 0.044 Neutral MLH1 P40692 S87E 87 S E 0.378 Neutral MLH1 P40692 S87F 87 S F 0.77 Pathogenic MLH1 P40692 S87G 87 S G 0.322 Neutral MLH1 P40692 S87H 87 S H 0.696 Pathogenic MLH1 P40692 S87I 87 S I 0.468 Neutral MLH1 P40692 S87K 87 S K 0.386 Neutral MLH1 P40692 S87L 87 S L 0.476 Neutral MLH1 P40692 S87M 87 S M 0.91 Pathogenic MLH1 P40692 S87N 87 S N 0.042 Neutral MLH1 P40692 S87P 87 S P 0.484 Neutral MLH1 P40692 S87Q 87 S Q 0.418 Neutral MLH1 P40692 S87R 87 S R 0.406 Neutral MLH1 P40692 S87T 87 S T 0.046 Neutral MLH1 P40692 S87V 87 S V 0.418 Neutral MLH1 P40692 S87W 87 S W 0.916 Pathogenic MLH1 P40692 S87Y 87 S Y 0.89 Pathogenic MLH1 P40692 F88A 88 F A 0.478 Neutral MLH1 P40692 F88C 88 F C 0.672 Pathogenic MLH1 P40692 F88D 88 F D 0.24 Neutral MLH1 P40692 F88E 88 F E 0.492 Neutral MLH1 P40692 F88G 88 F G 0.478 Neutral MLH1 P40692 F88H 88 F H 0.726 Pathogenic MLH1 P40692 F88I 88 F I 0.626 Pathogenic MLH1 P40692 F88K 88 F K 0.828 Pathogenic MLH1 P40692 F88L 88 F L 0.636 Pathogenic MLH1 P40692 F88M 88 F M 0.744 Pathogenic MLH1 P40692 F88N 88 F N 0.7 Pathogenic MLH1 P40692 F88P 88 F P 0.952 Pathogenic MLH1 P40692 F88Q 88 F Q 0.716 Pathogenic MLH1 P40692 F88R 88 F R 0.908 Pathogenic MLH1 P40692 F88S 88 F S 0.802 Pathogenic MLH1 P40692 F88T 88 F T 0.598 Pathogenic MLH1 P40692 F88V 88 F V 0.862 Pathogenic MLH1 P40692 F88W 88 F W 0.942 Pathogenic MLH1 P40692 F88Y 88 F Y 0.284 Neutral MLH1 P40692 E89A 89 E A 0.66 Pathogenic MLH1 P40692 E89C 89 E C 0.596 Pathogenic MLH1 P40692 E89D 89 E D 0.09 Neutral MLH1 P40692 E89F 89 E F 0.898 Pathogenic MLH1 P40692 E89G 89 E G 0.096 Neutral MLH1 P40692 E89H 89 E H 0.646 Pathogenic MLH1 P40692 E89I 89 E I 0.944 Pathogenic MLH1 P40692 E89K 89 E K 0.808 Pathogenic MLH1 P40692 E89L 89 E L 0.484 Neutral MLH1 P40692 E89M 89 E M 0.756 Pathogenic MLH1 P40692 E89N 89 E N 0.134 Neutral MLH1 P40692 E89P 89 E P 0.89 Pathogenic MLH1 P40692 E89Q 89 E Q 0.094 Neutral MLH1 P40692 E89R 89 E R 0.778 Pathogenic MLH1 P40692 E89S 89 E S 0.154 Neutral MLH1 P40692 E89T 89 E T 0.386 Neutral MLH1 P40692 E89V 89 E V 0.882 Pathogenic MLH1 P40692 E89W 89 E W 0.962 Pathogenic MLH1 P40692 E89Y 89 E Y 0.932 Pathogenic MLH1 P40692 R9A 9 R A 0.344 Neutral MLH1 P40692 R9C 9 R C 0.532 Pathogenic MLH1 P40692 R9D 9 R D 0.634 Pathogenic MLH1 P40692 R9E 9 R E 0.268 Neutral MLH1 P40692 R9F 9 R F 0.906 Pathogenic MLH1 P40692 R9G 9 R G 0.196 Neutral MLH1 P40692 R9H 9 R H 0.038 Neutral MLH1 P40692 R9I 9 R I 0.504 Pathogenic MLH1 P40692 R9K 9 R K 0.062 Neutral MLH1 P40692 R9L 9 R L 0.392 Neutral MLH1 P40692 R9M 9 R M 0.652 Pathogenic MLH1 P40692 R9N 9 R N 0.504 Pathogenic MLH1 P40692 R9P 9 R P 0.82 Pathogenic MLH1 P40692 R9Q 9 R Q 0.024 Neutral MLH1 P40692 R9S 9 R S 0.43 Neutral MLH1 P40692 R9T 9 R T 0.45 Neutral MLH1 P40692 R9V 9 R V 0.126 Neutral MLH1 P40692 R9W 9 R W 0.894 Pathogenic MLH1 P40692 R9Y 9 R Y 0.864 Pathogenic MLH1 P40692 D90A 90 D A 0.788 Pathogenic MLH1 P40692 D90C 90 D C 0.898 Pathogenic MLH1 P40692 D90E 90 D E 0.886 Pathogenic MLH1 P40692 D90F 90 D F 0.984 Pathogenic MLH1 P40692 D90G 90 D G 0.944 Pathogenic MLH1 P40692 D90H 90 D H 0.612 Pathogenic MLH1 P40692 D90I 90 D I 0.972 Pathogenic MLH1 P40692 D90K 90 D K 0.76 Pathogenic MLH1 P40692 D90L 90 D L 0.738 Pathogenic MLH1 P40692 D90M 90 D M 0.96 Pathogenic MLH1 P40692 D90N 90 D N 0.846 Pathogenic MLH1 P40692 D90P 90 D P 0.896 Pathogenic MLH1 P40692 D90Q 90 D Q 0.322 Neutral MLH1 P40692 D90R 90 D R 0.956 Pathogenic MLH1 P40692 D90S 90 D S 0.632 Pathogenic MLH1 P40692 D90T 90 D T 0.81 Pathogenic MLH1 P40692 D90V 90 D V 0.992 Pathogenic MLH1 P40692 D90W 90 D W 0.982 Pathogenic MLH1 P40692 D90Y 90 D Y 0.974 Pathogenic MLH1 P40692 L91A 91 L A 0.704 Pathogenic MLH1 P40692 L91C 91 L C 0.82 Pathogenic MLH1 P40692 L91D 91 L D 0.888 Pathogenic MLH1 P40692 L91E 91 L E 0.278 Neutral MLH1 P40692 L91F 91 L F 0.904 Pathogenic MLH1 P40692 L91G 91 L G 0.826 Pathogenic MLH1 P40692 L91H 91 L H 0.908 Pathogenic MLH1 P40692 L91I 91 L I 0.936 Pathogenic MLH1 P40692 L91K 91 L K 0.724 Pathogenic MLH1 P40692 L91M 91 L M 0.662 Pathogenic MLH1 P40692 L91N 91 L N 0.764 Pathogenic MLH1 P40692 L91P 91 L P 0.994 Pathogenic MLH1 P40692 L91Q 91 L Q 0.732 Pathogenic MLH1 P40692 L91R 91 L R 0.978 Pathogenic MLH1 P40692 L91S 91 L S 0.318 Neutral MLH1 P40692 L91T 91 L T 0.602 Pathogenic MLH1 P40692 L91V 91 L V 0.47 Neutral MLH1 P40692 L91W 91 L W 0.892 Pathogenic MLH1 P40692 L91Y 91 L Y 0.88 Pathogenic MLH1 P40692 A92C 92 A C 0.392 Neutral MLH1 P40692 A92D 92 A D 0.524 Pathogenic MLH1 P40692 A92E 92 A E 0.414 Neutral MLH1 P40692 A92F 92 A F 0.756 Pathogenic MLH1 P40692 A92G 92 A G 0.008 Neutral MLH1 P40692 A92H 92 A H 0.356 Neutral MLH1 P40692 A92I 92 A I 0.514 Pathogenic MLH1 P40692 A92K 92 A K 0.4 Neutral MLH1 P40692 A92L 92 A L 0.472 Neutral MLH1 P40692 A92M 92 A M 0.526 Pathogenic MLH1 P40692 A92N 92 A N 0.414 Neutral MLH1 P40692 A92P 92 A P 0.474 Neutral MLH1 P40692 A92Q 92 A Q 0.37 Neutral MLH1 P40692 A92R 92 A R 0.444 Neutral MLH1 P40692 A92S 92 A S 0.01 Neutral MLH1 P40692 A92T 92 A T 0.024 Neutral MLH1 P40692 A92V 92 A V 0.38 Neutral MLH1 P40692 A92W 92 A W 0.786 Pathogenic MLH1 P40692 A92Y 92 A Y 0.788 Pathogenic MLH1 P40692 S93A 93 S A 0.088 Neutral MLH1 P40692 S93C 93 S C 0.412 Neutral MLH1 P40692 S93D 93 S D 0.378 Neutral MLH1 P40692 S93E 93 S E 0.448 Neutral MLH1 P40692 S93F 93 S F 0.83 Pathogenic MLH1 P40692 S93G 93 S G 0.322 Neutral MLH1 P40692 S93H 93 S H 0.482 Neutral MLH1 P40692 S93I 93 S I 0.536 Pathogenic MLH1 P40692 S93K 93 S K 0.44 Neutral MLH1 P40692 S93L 93 S L 0.55 Pathogenic MLH1 P40692 S93M 93 S M 0.934 Pathogenic MLH1 P40692 S93N 93 S N 0.048 Neutral MLH1 P40692 S93P 93 S P 0.564 Pathogenic MLH1 P40692 S93Q 93 S Q 0.472 Neutral MLH1 P40692 S93R 93 S R 0.462 Neutral MLH1 P40692 S93T 93 S T 0.068 Neutral MLH1 P40692 S93V 93 S V 0.796 Pathogenic MLH1 P40692 S93W 93 S W 0.922 Pathogenic MLH1 P40692 S93Y 93 S Y 0.904 Pathogenic MLH1 P40692 I94A 94 I A 0.47 Neutral MLH1 P40692 I94C 94 I C 0.328 Neutral MLH1 P40692 I94D 94 I D 0.76 Pathogenic MLH1 P40692 I94E 94 I E 0.764 Pathogenic MLH1 P40692 I94F 94 I F 0.966 Pathogenic MLH1 P40692 I94G 94 I G 0.808 Pathogenic MLH1 P40692 I94H 94 I H 0.84 Pathogenic MLH1 P40692 I94K 94 I K 0.852 Pathogenic MLH1 P40692 I94L 94 I L 0.084 Neutral MLH1 P40692 I94M 94 I M 0.17 Neutral MLH1 P40692 I94N 94 I N 0.786 Pathogenic MLH1 P40692 I94P 94 I P 0.944 Pathogenic MLH1 P40692 I94Q 94 I Q 0.796 Pathogenic MLH1 P40692 I94R 94 I R 0.88 Pathogenic MLH1 P40692 I94S 94 I S 0.626 Pathogenic MLH1 P40692 I94T 94 I T 0.164 Neutral MLH1 P40692 I94V 94 I V 0.152 Neutral MLH1 P40692 I94W 94 I W 0.988 Pathogenic MLH1 P40692 I94Y 94 I Y 0.984 Pathogenic MLH1 P40692 S95A 95 S A 0.05 Neutral MLH1 P40692 S95C 95 S C 0.35 Neutral MLH1 P40692 S95D 95 S D 0.416 Neutral MLH1 P40692 S95E 95 S E 0.4 Neutral MLH1 P40692 S95F 95 S F 0.756 Pathogenic MLH1 P40692 S95G 95 S G 0.022 Neutral MLH1 P40692 S95H 95 S H 0.732 Pathogenic MLH1 P40692 S95I 95 S I 0.51 Pathogenic MLH1 P40692 S95K 95 S K 0.408 Neutral MLH1 P40692 S95L 95 S L 0.526 Pathogenic MLH1 P40692 S95M 95 S M 0.934 Pathogenic MLH1 P40692 S95N 95 S N 0.04 Neutral MLH1 P40692 S95P 95 S P 0.528 Pathogenic MLH1 P40692 S95Q 95 S Q 0.416 Neutral MLH1 P40692 S95R 95 S R 0.41 Neutral MLH1 P40692 S95T 95 S T 0.044 Neutral MLH1 P40692 S95V 95 S V 0.792 Pathogenic MLH1 P40692 S95W 95 S W 0.922 Pathogenic MLH1 P40692 S95Y 95 S Y 0.896 Pathogenic MLH1 P40692 T96A 96 T A 0.642 Pathogenic MLH1 P40692 T96C 96 T C 0.876 Pathogenic MLH1 P40692 T96D 96 T D 0.89 Pathogenic MLH1 P40692 T96E 96 T E 0.934 Pathogenic MLH1 P40692 T96F 96 T F 0.928 Pathogenic MLH1 P40692 T96G 96 T G 0.184 Neutral MLH1 P40692 T96H 96 T H 0.878 Pathogenic MLH1 P40692 T96I 96 T I 0.92 Pathogenic MLH1 P40692 T96K 96 T K 0.906 Pathogenic MLH1 P40692 T96L 96 T L 0.91 Pathogenic MLH1 P40692 T96M 96 T M 0.974 Pathogenic MLH1 P40692 T96N 96 T N 0.824 Pathogenic MLH1 P40692 T96P 96 T P 0.938 Pathogenic MLH1 P40692 T96Q 96 T Q 0.828 Pathogenic MLH1 P40692 T96R 96 T R 0.708 Pathogenic MLH1 P40692 T96S 96 T S 0.11 Neutral MLH1 P40692 T96V 96 T V 0.892 Pathogenic MLH1 P40692 T96W 96 T W 0.99 Pathogenic MLH1 P40692 T96Y 96 T Y 0.99 Pathogenic MLH1 P40692 Y97A 97 Y A 0.336 Neutral MLH1 P40692 Y97C 97 Y C 0.542 Pathogenic MLH1 P40692 Y97D 97 Y D 0.8 Pathogenic MLH1 P40692 Y97E 97 Y E 0.736 Pathogenic MLH1 P40692 Y97F 97 Y F 0.07 Neutral MLH1 P40692 Y97G 97 Y G 0.382 Neutral MLH1 P40692 Y97H 97 Y H 0.142 Neutral MLH1 P40692 Y97I 97 Y I 0.662 Pathogenic MLH1 P40692 Y97K 97 Y K 0.826 Pathogenic MLH1 P40692 Y97L 97 Y L 0.186 Neutral MLH1 P40692 Y97M 97 Y M 0.134 Neutral MLH1 P40692 Y97N 97 Y N 0.62 Pathogenic MLH1 P40692 Y97P 97 Y P 0.684 Pathogenic MLH1 P40692 Y97Q 97 Y Q 0.544 Pathogenic MLH1 P40692 Y97R 97 Y R 0.768 Pathogenic MLH1 P40692 Y97S 97 Y S 0.38 Neutral MLH1 P40692 Y97T 97 Y T 0.538 Pathogenic MLH1 P40692 Y97V 97 Y V 0.702 Pathogenic MLH1 P40692 Y97W 97 Y W 0.776 Pathogenic MLH1 P40692 G98A 98 G A 0.958 Pathogenic MLH1 P40692 G98C 98 G C 0.942 Pathogenic MLH1 P40692 G98D 98 G D 0.998 Pathogenic MLH1 P40692 G98E 98 G E 0.982 Pathogenic MLH1 P40692 G98F 98 G F 0.98 Pathogenic MLH1 P40692 G98H 98 G H 0.984 Pathogenic MLH1 P40692 G98I 98 G I 0.972 Pathogenic MLH1 P40692 G98K 98 G K 0.984 Pathogenic MLH1 P40692 G98L 98 G L 0.982 Pathogenic MLH1 P40692 G98M 98 G M 0.994 Pathogenic MLH1 P40692 G98N 98 G N 0.986 Pathogenic MLH1 P40692 G98P 98 G P 0.962 Pathogenic MLH1 P40692 G98Q 98 G Q 0.99 Pathogenic MLH1 P40692 G98R 98 G R 0.746 Pathogenic MLH1 P40692 G98S 98 G S 0.864 Pathogenic MLH1 P40692 G98T 98 G T 0.724 Pathogenic MLH1 P40692 G98V 98 G V 0.984 Pathogenic MLH1 P40692 G98W 98 G W 0.976 Pathogenic MLH1 P40692 G98Y 98 G Y 0.956 Pathogenic MLH1 P40692 F99A 99 F A 0.51 Pathogenic MLH1 P40692 F99C 99 F C 0.716 Pathogenic MLH1 P40692 F99D 99 F D 0.802 Pathogenic MLH1 P40692 F99E 99 F E 0.852 Pathogenic MLH1 P40692 F99G 99 F G 0.228 Neutral MLH1 P40692 F99H 99 F H 0.76 Pathogenic MLH1 P40692 F99I 99 F I 0.678 Pathogenic MLH1 P40692 F99K 99 F K 0.838 Pathogenic MLH1 P40692 F99L 99 F L 0.694 Pathogenic MLH1 P40692 F99M 99 F M 0.78 Pathogenic MLH1 P40692 F99N 99 F N 0.718 Pathogenic MLH1 P40692 F99P 99 F P 0.966 Pathogenic MLH1 P40692 F99Q 99 F Q 0.732 Pathogenic MLH1 P40692 F99R 99 F R 0.906 Pathogenic MLH1 P40692 F99S 99 F S 0.83 Pathogenic MLH1 P40692 F99T 99 F T 0.314 Neutral MLH1 P40692 F99V 99 F V 0.818 Pathogenic MLH1 P40692 F99W 99 F W 0.894 Pathogenic MLH1 P40692 F99Y 99 F Y 0.632 Pathogenic MSH2 P43246 M1A 1 M A 0.102 Neutral MSH2 P43246 M1C 1 M C 0.06 Neutral MSH2 P43246 M1D 1 M D 0.194 Neutral MSH2 P43246 M1E 1 M E 0.05 Neutral MSH2 P43246 M1F 1 M F 0.28 Neutral MSH2 P43246 M1G 1 M G 0.138 Neutral MSH2 P43246 M1H 1 M H 0.086 Neutral MSH2 P43246 M1I 1 M I 0.152 Neutral MSH2 P43246 M1K 1 M K 0.078 Neutral MSH2 P43246 M1L 1 M L 0.094 Neutral MSH2 P43246 M1N 1 M N 0.23 Neutral MSH2 P43246 M1P 1 M P 0.042 Neutral MSH2 P43246 M1Q 1 M Q 0.094 Neutral MSH2 P43246 M1R 1 M R 0.224 Neutral MSH2 P43246 M1S 1 M S 0.19 Neutral MSH2 P43246 M1T 1 M T 0.168 Neutral MSH2 P43246 M1V 1 M V 0.084 Neutral MSH2 P43246 M1W 1 M W 0.594 Pathogenic MSH2 P43246 M1Y 1 M Y 0.48 Neutral MSH2 P43246 Q10A 10 Q A 0.036 Neutral MSH2 P43246 Q10C 10 Q C 0.048 Neutral MSH2 P43246 Q10D 10 Q D 0.002 Neutral MSH2 P43246 Q10E 10 Q E 0.008 Neutral MSH2 P43246 Q10F 10 Q F 0.284 Neutral MSH2 P43246 Q10G 10 Q G 0.032 Neutral MSH2 P43246 Q10H 10 Q H 0.076 Neutral MSH2 P43246 Q10I 10 Q I 0.3 Neutral MSH2 P43246 Q10K 10 Q K 0.018 Neutral MSH2 P43246 Q10L 10 Q L 0.35 Neutral MSH2 P43246 Q10M 10 Q M 0.218 Neutral MSH2 P43246 Q10N 10 Q N 0.018 Neutral MSH2 P43246 Q10P 10 Q P 0.234 Neutral MSH2 P43246 Q10R 10 Q R 0.008 Neutral MSH2 P43246 Q10S 10 Q S 0.034 Neutral MSH2 P43246 Q10T 10 Q T 0.146 Neutral MSH2 P43246 Q10V 10 Q V 0.288 Neutral MSH2 P43246 Q10W 10 Q W 0.49 Neutral MSH2 P43246 Q10Y 10 Q Y 0.424 Neutral MSH2 P43246 V100A 100 V A 0.084 Neutral MSH2 P43246 V100C 100 V C 0.372 Neutral MSH2 P43246 V100D 100 V D 0.86 Pathogenic MSH2 P43246 V100E 100 V E 0.976 Pathogenic MSH2 P43246 V100F 100 V F 0.892 Pathogenic MSH2 P43246 V100G 100 V G 0.884 Pathogenic MSH2 P43246 V100H 100 V H 0.832 Pathogenic MSH2 P43246 V100I 100 V I 0.192 Neutral MSH2 P43246 V100K 100 V K 0.986 Pathogenic MSH2 P43246 V100L 100 V L 0.226 Neutral MSH2 P43246 V100M 100 V M 0.832 Pathogenic MSH2 P43246 V100N 100 V N 0.918 Pathogenic MSH2 P43246 V100P 100 V P 0.718 Pathogenic MSH2 P43246 V100Q 100 V Q 0.982 Pathogenic MSH2 P43246 V100R 100 V R 0.954 Pathogenic MSH2 P43246 V100S 100 V S 0.724 Pathogenic MSH2 P43246 V100T 100 V T 0.77 Pathogenic MSH2 P43246 V100W 100 V W 0.92 Pathogenic MSH2 P43246 V100Y 100 V Y 0.948 Pathogenic MSH2 P43246 E101A 101 E A 0.596 Pathogenic MSH2 P43246 E101C 101 E C 0.764 Pathogenic MSH2 P43246 E101D 101 E D 0.894 Pathogenic MSH2 P43246 E101F 101 E F 0.962 Pathogenic MSH2 P43246 E101G 101 E G 0.332 Neutral MSH2 P43246 E101H 101 E H 0.666 Pathogenic MSH2 P43246 E101I 101 E I 0.984 Pathogenic MSH2 P43246 E101K 101 E K 0.908 Pathogenic MSH2 P43246 E101L 101 E L 0.976 Pathogenic MSH2 P43246 E101M 101 E M 0.912 Pathogenic MSH2 P43246 E101N 101 E N 0.782 Pathogenic MSH2 P43246 E101P 101 E P 0.94 Pathogenic MSH2 P43246 E101Q 101 E Q 0.366 Neutral MSH2 P43246 E101R 101 E R 0.934 Pathogenic MSH2 P43246 E101S 101 E S 0.898 Pathogenic MSH2 P43246 E101T 101 E T 0.848 Pathogenic MSH2 P43246 E101V 101 E V 0.922 Pathogenic MSH2 P43246 E101W 101 E W 0.98 Pathogenic MSH2 P43246 E101Y 101 E Y 0.96 Pathogenic MSH2 P43246 V102A 102 V A 0.328 Neutral MSH2 P43246 V102C 102 V C 0.71 Pathogenic MSH2 P43246 V102D 102 V D 0.862 Pathogenic MSH2 P43246 V102E 102 V E 0.978 Pathogenic MSH2 P43246 V102F 102 V F 0.648 Pathogenic MSH2 P43246 V102G 102 V G 0.894 Pathogenic MSH2 P43246 V102H 102 V H 0.82 Pathogenic MSH2 P43246 V102I 102 V I 0.124 Neutral 2 MSH2 P43246 V102K 102 V K 0.99 Pathogenic MSH2 P43246 V102L 102 V L 0.194 Neutral MSH2 P43246 V102M 102 V M 0.414 Neutral MSH2 P43246 V102N 102 V N 0.922 Pathogenic MSH2 P43246 V102P 102 V P 0.984 Pathogenic MSH2 P43246 V102Q 102 V Q 0.984 Pathogenic MSH2 P43246 V102R 102 V R 0.952 Pathogenic MSH2 P43246 V102S 102 V S 0.358 Neutral MSH2 P43246 V102T 102 V T 0.746 Pathogenic MSH2 P43246 V102W 102 V W 0.904 Pathogenic MSH2 P43246 V102Y 102 V Y 0.928 Pathogenic MSH2 P43246 Y103A 103 Y A 0.378 Neutral MSH2 P43246 Y103C 103 Y C 0.604 Pathogenic MSH2 P43246 Y103D 103 Y D 0.776 Pathogenic MSH2 P43246 Y103E 103 Y E 0.416 Neutral MSH2 P43246 Y103F 103 Y F 0.132 Neutral MSH2 P43246 Y103G 103 Y G 0.436 Neutral MSH2 P43246 Y103H 103 Y H 0.51 Pathogenic MSH2 P43246 Y103I 103 Y I 0.724 Pathogenic MSH2 P43246 Y103K 103 Y K 0.784 Pathogenic MSH2 P43246 Y103L 103 Y L 0.162 Neutral MSH2 P43246 Y103M 103 Y M 0.614 Pathogenic MSH2 P43246 Y103N 103 Y N 0.65 Pathogenic MSH2 P43246 Y103P 103 Y P 0.734 Pathogenic MSH2 P43246 Y103Q 103 Y Q 0.552 Pathogenic MSH2 P43246 Y103R 103 Y R 0.708 Pathogenic MSH2 P43246 Y103S 103 Y S 0.43 Neutral MSH2 P43246 Y103T 103 Y T 0.596 Pathogenic MSH2 P43246 Y103V 103 Y V 0.734 Pathogenic MSH2 P43246 Y103W 103 Y W 0.2 Neutral MSH2 P43246 K104A 104 K A 0.082 Neutral MSH2 P43246 K104C 104 K C 0.218 Neutral MSH2 P43246 K104D 104 K D 0.17 Neutral MSH2 P43246 K104E 104 K E 0.258 Neutral MSH2 P43246 K104F 104 K F 0.646 Pathogenic MSH2 P43246 K104G 104 K G 0.096 Neutral MSH2 P43246 K104H 104 K H 0.238 Neutral MSH2 P43246 K104I 104 K I 0.692 Pathogenic MSH2 P43246 K104L 104 K L 0.65 Pathogenic MSH2 P43246 K104M 104 K M 0.482 Neutral MSH2 P43246 K104N 104 K N 0.23 Neutral MSH2 P43246 K104P 104 K P 0.084 Neutral MSH2 P43246 K104Q 104 K Q 0.046 Neutral MSH2 P43246 K104R 104 K R 0.032 Neutral MSH2 P43246 K104S 104 K S 0.064 Neutral MSH2 P43246 K104T 104 K T 0.066 Neutral MSH2 P43246 K104V 104 K V 0.668 Pathogenic MSH2 P43246 K104W 104 K W 0.874 Pathogenic MSH2 P43246 K104Y 104 K Y 0.796 Pathogenic MSH2 P43246 N105A 105 N A 0.11 Neutral MSH2 P43246 N105C 105 N C 0.558 Pathogenic MSH2 P43246 N105D 105 N D 0.046 Neutral MSH2 P43246 N105E 105 N E 0.596 Pathogenic MSH2 P43246 N105F 105 N F 0.866 Pathogenic MSH2 P43246 N105G 105 N G 0.052 Neutral MSH2 P43246 N105H 105 N H 0.75 Pathogenic MSH2 P43246 N105I 105 N I 0.858 Pathogenic MSH2 P43246 N105K 105 N K 0.084 Neutral MSH2 P43246 N105L 105 N L 0.834 Pathogenic MSH2 P43246 N105M 105 N M 0.784 Pathogenic MSH2 P43246 N105P 105 N P 0.528 Pathogenic MSH2 P43246 N105Q 105 N Q 0.122 Neutral MSH2 P43246 N105R 105 N R 0.462 Neutral MSH2 P43246 N105S 105 N S 0.022 Neutral MSH2 P43246 N105T 105 N T 0.074 Neutral MSH2 P43246 N105V 105 N V 0.12 Neutral MSH2 P43246 N105W 105 N W 0.93 Pathogenic MSH2 P43246 N105Y 105 N Y 0.916 Pathogenic MSH2 P43246 R106A 106 R A 0.312 Neutral MSH2 P43246 R106C 106 R C 0.662 Pathogenic MSH2 P43246 R106D 106 R D 0.626 Pathogenic MSH2 P43246 R106E 106 R E 0.55 Pathogenic MSH2 P43246 R106F 106 R F 0.938 Pathogenic MSH2 P43246 R106G 106 R G 0.024 Neutral MSH2 P43246 R106H 106 R H 0.024 Neutral MSH2 P43246 R106I 106 R I 0.768 Pathogenic MSH2 P43246 R106K 106 R K 0.118 Neutral 1 MSH2 P43246 R106L 106 R L 0.704 Pathogenic MSH2 P43246 R106M 106 R M 0.672 Pathogenic MSH2 P43246 R106N 106 R N 0.022 Neutral MSH2 P43246 R106P 106 R P 0.676 Pathogenic MSH2 P43246 R106Q 106 R Q 0.016 Neutral MSH2 P43246 R106S 106 R S 0.054 Neutral MSH2 P43246 R106T 106 R T 0.086 Neutral MSH2 P43246 R106V 106 R V 0.824 Pathogenic MSH2 P43246 R106W 106 R W 0.914 Pathogenic MSH2 P43246 R106Y 106 R Y 0.894 Pathogenic MSH2 P43246 A107C 107 A C 0.632 Pathogenic MSH2 P43246 A107D 107 A D 0.758 Pathogenic MSH2 P43246 A107E 107 A E 0.792 Pathogenic MSH2 P43246 A107F 107 A F 0.912 Pathogenic MSH2 P43246 A107G 107 A G 0.036 Neutral MSH2 P43246 A107H 107 A H 0.79 Pathogenic MSH2 P43246 A107I 107 A I 0.92 Pathogenic MSH2 P43246 A107K 107 A K 0.512 Pathogenic MSH2 P43246 A107L 107 A L 0.582 Pathogenic MSH2 P43246 A107M 107 A M 0.478 Neutral MSH2 P43246 A107N 107 A N 0.538 Pathogenic MSH2 P43246 A107P 107 A P 0.234 Neutral MSH2 P43246 A107Q 107 A Q 0.76 Pathogenic MSH2 P43246 A107R 107 A R 0.56 Pathogenic MSH2 P43246 A107S 107 A S 0.04 Neutral MSH2 P43246 A107T 107 A T 0.06 Neutral MSH2 P43246 A107V 107 A V 0.406 Neutral MSH2 P43246 A107W 107 A W 0.906 Pathogenic MSH2 P43246 A107Y 107 A Y 0.898 Pathogenic MSH2 P43246 G108A 108 G A 0.01 Neutral MSH2 P43246 G108C 108 G C 0.374 Neutral MSH2 P43246 G108D 108 G D 0.438 Neutral MSH2 P43246 G108E 108 G E 0.348 Neutral MSH2 P43246 G108F 108 G F 0.776 Pathogenic MSH2 P43246 G108H 108 G H 0.482 Neutral MSH2 P43246 G108I 108 G I 0.692 Pathogenic MSH2 P43246 G108K 108 G K 0.398 Neutral MSH2 P43246 G108L 108 G L 0.694 Pathogenic MSH2 P43246 G108M 108 G M 0.622 Pathogenic MSH2 P43246 G108N 108 G N 0.262 Neutral MSH2 P43246 G108P 108 G P 0.696 Pathogenic MSH2 P43246 G108Q 108 G Q 0.284 Neutral MSH2 P43246 G108R 108 G R 0.404 Neutral MSH2 P43246 G108S 108 G S 0.032 Neutral MSH2 P43246 G108T 108 G T 0.36 Neutral MSH2 P43246 G108V 108 G V 0.672 Pathogenic MSH2 P43246 G108W 108 G W 0.774 Pathogenic MSH2 P43246 G108Y 108 G Y 0.758 Pathogenic MSH2 P43246 N109A 109 N A 0.052 Neutral MSH2 P43246 N109C 109 N C 0.152 Neutral MSH2 P43246 N109D 109 N D 0.12 Neutral MSH2 P43246 N109E 109 N E 0.154 Neutral MSH2 P43246 N109F 109 N F 0.376 Neutral MSH2 P43246 N109G 109 N G 0.018 Neutral MSH2 P43246 N109H 109 N H 0.272 Neutral MSH2 P43246 N109I 109 N I 0.284 Neutral MSH2 P43246 N109K 109 N K 0.034 Neutral MSH2 P43246 N109L 109 N L 0.286 Neutral MSH2 P43246 N109M 109 N M 0.234 Neutral MSH2 P43246 N109P 109 N P 0.252 Neutral MSH2 P43246 N109Q 109 N Q 0.096 Neutral MSH2 P43246 N109R 109 N R 0.156 Neutral MSH2 P43246 N109S 109 N S 0 Neutral MSH2 P43246 N109T 109 N T 0.006 Neutral MSH2 P43246 N109V 109 N V 0.298 Neutral MSH2 P43246 N109W 109 N W 0.5 Pathogenic MSH2 P43246 N109Y 109 N Y 0.444 Neutral MSH2 P43246 L11A 11 L A 0.106 Neutral MSH2 P43246 L11C 11 L C 0.144 Neutral MSH2 P43246 L11D 11 L D 0.044 Neutral MSH2 P43246 L11E 11 L E 0.056 Neutral MSH2 P43246 L11F 11 L F 0.448 Neutral MSH2 P43246 L11G 11 L G 0.27 Neutral MSH2 P43246 L11H 11 L H 0.132 Neutral MSH2 P43246 L11I 11 L I 0.004 Neutral MSH2 P43246 L11K 11 L K 0.286 Neutral MSH2 P43246 L11M 11 L M 0.008 Neutral MSH2 P43246 L11N 11 L N 0.248 Neutral MSH2 P43246 L11P 11 L P 0.396 Neutral MSH2 P43246 L11Q 11 L Q 0.1 Neutral MSH2 P43246 L11R 11 L R 0.506 Pathogenic MSH2 P43246 L11S 11 L S 0.196 Neutral MSH2 P43246 L11T 11 L T 0.134 Neutral MSH2 P43246 L11V 11 L V 0 Neutral MSH2 P43246 L11W 11 L W 0.544 Pathogenic MSH2 P43246 L11Y 11 L Y 0.532 Pathogenic MSH2 P43246 K110A 110 K A 0.062 Neutral MSH2 P43246 K110C 110 K C 0.048 Neutral MSH2 P43246 K110D 110 K D 0.09 Neutral MSH2 P43246 K110E 110 K E 0.06 Neutral MSH2 P43246 K110F 110 K F 0.284 Neutral MSH2 P43246 K110G 110 K G 0.118 Neutral MSH2 P43246 K110H 110 K H 0.002 Neutral MSH2 P43246 K110I 110 K I 0.254 Neutral MSH2 P43246 K110L 110 K L 0.296 Neutral MSH2 P43246 K110M 110 K M 0.172 Neutral MSH2 P43246 K110N 110 K N 0.008 Neutral MSH2 P43246 K110P 110 K P 0.304 Neutral MSH2 P43246 K110Q 110 K Q 0.008 Neutral MSH2 P43246 K110R 110 K R 0.094 Neutral MSH2 P43246 K110S 110 K S 0.094 Neutral MSH2 P43246 K110T 110 K T 0.104 Neutral MSH2 P43246 K110V 110 K V 0.232 Neutral MSH2 P43246 K110W 110 K W 0.582 Pathogenic MSH2 P43246 K110Y 110 K Y 0.48 Neutral MSH2 P43246 A111C 111 A C 0.182 Neutral MSH2 P43246 A111D 111 A D 0.266 Neutral MSH2 P43246 A111E 111 A E 0.306 Neutral MSH2 P43246 A111F 111 A F 0.468 Neutral MSH2 P43246 A111G 111 A G 0.006 Neutral MSH2 P43246 A111H 111 A H 0.304 Neutral MSH2 P43246 A111I 111 A I 0.406 Neutral MSH2 P43246 A111K 111 A K 0.354 Neutral MSH2 P43246 A111L 111 A L 0.4 Neutral MSH2 P43246 A111M 111 A M 0.29 Neutral MSH2 P43246 A111N 111 A N 0.308 Neutral MSH2 P43246 A111P 111 A P 0.3 Neutral MSH2 P43246 A111Q 111 A Q 0.278 Neutral MSH2 P43246 A111R 111 A R 0.318 Neutral MSH2 P43246 A111S 111 A S 0.004 Neutral MSH2 P43246 A111T 111 A T 0.014 Neutral MSH2 P43246 A111V 111 A V 0.242 Neutral MSH2 P43246 A111W 111 A W 0.504 Pathogenic MSH2 P43246 A111Y 111 A Y 0.482 Neutral MSH2 P43246 S112A 112 S A 0.01 Neutral MSH2 P43246 S112C 112 S C 0.032 Neutral MSH2 P43246 S112D 112 S D 0.044 Neutral MSH2 P43246 S112E 112 S E 0.148 Neutral MSH2 P43246 S112F 112 S F 0.264 Neutral MSH2 P43246 S112G 112 S G 0.066 Neutral MSH2 P43246 S112H 112 S H 0.238 Neutral MSH2 P43246 S112I 112 S I 0.124 Neutral MSH2 P43246 S112K 112 S K 0.146 Neutral MSH2 P43246 S112L 112 S L 0.028 Neutral MSH2 P43246 S112M 112 S M 0.332 Neutral MSH2 P43246 S112N 112 S N 0.018 Neutral MSH2 P43246 S112P 112 S P 0.116 Neutral MSH2 P43246 S112Q 112 S Q 0.19 Neutral MSH2 P43246 S112R 112 S R 0.248 Neutral MSH2 P43246 S112T 112 S T 0.02 Neutral MSH2 P43246 S112V 112 S V 0.068 Neutral MSH2 P43246 S112W 112 S W 0.49 Neutral MSH2 P43246 S112Y 112 S Y 0.448 Neutral MSH2 P43246 K113A 113 K A 0.088 Neutral MSH2 P43246 K113C 113 K C 0.062 Neutral MSH2 P43246 K113D 113 K D 0.102 Neutral MSH2 P43246 K113E 113 K E 0.112 Neutral MSH2 P43246 K113F 113 K F 0.368 Neutral MSH2 P43246 K113G 113 K G 0.186 Neutral MSH2 P43246 K113H 113 K H 0.086 Neutral MSH2 P43246 K113I 113 K I 0.4 Neutral MSH2 P43246 K113L 113 K L 0.384 Neutral MSH2 P43246 K113M 113 K M 0.194 Neutral MSH2 P43246 K113N 113 K N 0.124 Neutral MSH2 P43246 K113P 113 K P 0.392 Neutral MSH2 P43246 K113Q 113 K Q 0.07 Neutral MSH2 P43246 K113R 113 K R 0.062 Neutral MSH2 P43246 K113S 113 K S 0.288 Neutral MSH2 P43246 K113T 113 K T 0.15 Neutral MSH2 P43246 K113V 113 K V 0.302 Neutral MSH2 P43246 K113W 113 K W 0.634 Pathogenic MSH2 P43246 K113Y 113 K Y 0.586 Pathogenic MSH2 P43246 E114A 114 E A 0.122 Neutral MSH2 P43246 E114C 114 E C 0.068 Neutral MSH2 P43246 E114D 114 E D 0 Neutral MSH2 P43246 E114F 114 E F 0.296 Neutral MSH2 P43246 E114G 114 E G 0.002 Neutral MSH2 P43246 E114H 114 E H 0.108 Neutral MSH2 P43246 E114I 114 E I 0.31 Neutral MSH2 P43246 E114K 114 E K 0.002 Neutral MSH2 P43246 E114L 114 E L 0.308 Neutral MSH2 P43246 E114M 114 E M 0.176 Neutral MSH2 P43246 E114N 114 E N 0.002 Neutral MSH2 P43246 E114P 114 E P 0.322 Neutral MSH2 P43246 E114Q 114 E Q 0.018 Neutral MSH2 P43246 E114R 114 E R 0.048 Neutral MSH2 P43246 E114S 114 E S 0.17 Neutral MSH2 P43246 E114T 114 E T 0.144 Neutral MSH2 P43246 E114V 114 E V 0.272 Neutral MSH2 P43246 E114W 114 E W 0.508 Pathogenic MSH2 P43246 E114Y 114 E Y 0.404 Neutral MSH2 P43246 N115A 115 N A 0.102 Neutral MSH2 P43246 N115C 115 N C 0.252 Neutral MSH2 P43246 N115D 115 N D 0.188 Neutral MSH2 P43246 N115E 115 N E 0.16 Neutral MSH2 P43246 N115F 115 N F 0.582 Pathogenic MSH2 P43246 N115G 115 N G 0.026 Neutral MSH2 P43246 N115H 115 N H 0.026 Neutral MSH2 P43246 N115I 115 N I 0.426 Neutral MSH2 P43246 N115K 115 N K 0.358 Neutral MSH2 P43246 N115L 115 N L 0.43 Neutral MSH2 P43246 N115M 115 N M 0.362 Neutral MSH2 P43246 N115P 115 N P 0.386 Neutral MSH2 P43246 N115Q 115 N Q 0.02 Neutral MSH2 P43246 N115R 115 N R 0.246 Neutral MSH2 P43246 N115S 115 N S 0.032 Neutral MSH2 P43246 N115T 115 N T 0.016 Neutral MSH2 P43246 N115V 115 N V 0.438 Neutral MSH2 P43246 N115W 115 N W 0.708 Pathogenic MSH2 P43246 N115Y 115 N Y 0.666 Pathogenic MSH2 P43246 D116A 116 D A 0.028 Neutral MSH2 P43246 D116C 116 D C 0.328 Neutral MSH2 P43246 D116E 116 D E 0.016 Neutral MSH2 P43246 D116F 116 D F 0.626 Pathogenic MSH2 P43246 D116G 116 D G 0.112 Neutral MSH2 P43246 D116H 116 D H 0.152 Neutral MSH2 P43246 D116I 116 D I 0.452 Neutral MSH2 P43246 D116K 116 D K 0.31 Neutral MSH2 P43246 D116L 116 D L 0.436 Neutral MSH2 P43246 D116M 116 D M 0.338 Neutral MSH2 P43246 D116N 116 D N 0 Neutral MSH2 P43246 D116P 116 D P 0.458 Neutral MSH2 P43246 D116Q 116 D Q 0.014 Neutral MSH2 P43246 D116R 116 D R 0.372 Neutral MSH2 P43246 D116S 116 D S 0.024 Neutral MSH2 P43246 D116T 116 D T 0.158 Neutral MSH2 P43246 D116V 116 D V 0.434 Neutral MSH2 P43246 D116W 116 D W 0.746 Pathogenic MSH2 P43246 D116Y 116 D Y 0.714 Pathogenic MSH2 P43246 W117A 117 W A 0.472 Neutral MSH2 P43246 W117C 117 W C 0.476 Neutral MSH2 P43246 W117D 117 W D 0.508 Pathogenic MSH2 P43246 W117E 117 W E 0.834 Pathogenic MSH2 P43246 W117F 117 W F 0.17 Neutral MSH2 P43246 W117G 117 W G 0.468 Neutral MSH2 P43246 W117H 117 W H 0.718 Pathogenic MSH2 P43246 W117I 117 W I 0.538 Pathogenic MSH2 P43246 W117K 117 W K 0.894 Pathogenic MSH2 P43246 W117L 117 W L 0.204 Neutral MSH2 P43246 W117M 117 W M 0.718 Pathogenic MSH2 P43246 W117N 117 W N 0.478 Neutral MSH2 P43246 W117P 117 W P 0.512 Pathogenic MSH2 P43246 W117Q 117 W Q 0.646 Pathogenic MSH2 P43246 W117R 117 W R 0.716 Pathogenic MSH2 P43246 W117S 117 W S 0.48 Neutral MSH2 P43246 W117T 117 W T 0.472 Neutral MSH2 P43246 W117V 117 W V 0.202 Neutral MSH2 P43246 W117Y 117 W Y 0.2 Neutral MSH2 P43246 Y118A 118 Y A 0.124 Neutral MSH2 P43246 Y118C 118 Y C 0.326 Neutral MSH2 P43246 Y118D 118 Y D 0.59 Pathogenic MSH2 P43246 Y118E 118 Y E 0.102 Neutral MSH2 P43246 Y118F 118 Y F 0.076 Neutral MSH2 P43246 Y118G 118 Y G 0.33 Neutral MSH2 P43246 Y118H 118 Y H 0.084 Neutral MSH2 P43246 Y118I 118 Y I 0.07 Neutral MSH2 P43246 Y118K 118 Y K 0.076 Neutral MSH2 P43246 Y118L 118 Y L 0.262 Neutral MSH2 P43246 Y118M 118 Y M 0.35 Neutral MSH2 P43246 Y118N 118 Y N 0.332 Neutral MSH2 P43246 Y118P 118 Y P 0.34 Neutral MSH2 P43246 Y118Q 118 Y Q 0.12 Neutral MSH2 P43246 Y118R 118 Y R 0.094 Neutral MSH2 P43246 Y118S 118 Y S 0.17 Neutral MSH2 P43246 Y118T 118 Y T 0.136 Neutral MSH2 P43246 Y118V 118 Y V 0.068 Neutral MSH2 P43246 Y118W 118 Y W 0.332 Neutral MSH2 P43246 L119A 119 L A 0.186 Neutral MSH2 P43246 L119C 119 L C 0.098 Neutral MSH2 P43246 L119D 119 L D 0.9 Pathogenic MSH2 P43246 L119E 119 L E 0.88 Pathogenic MSH2 P43246 L119F 119 L F 0.976 Pathogenic MSH2 P43246 L119G 119 L G 0.804 Pathogenic MSH2 P43246 L119H 119 L H 0.798 Pathogenic MSH2 P43246 L119I 119 L I 0.134 Neutral MSH2 P43246 L119K 119 L K 0.156 Neutral MSH2 P43246 L119M 119 L M 0.186 Neutral MSH2 P43246 L119N 119 L N 0.77 Pathogenic MSH2 P43246 L119P 119 L P 0.686 Pathogenic MSH2 P43246 L119Q 119 L Q 0.614 Pathogenic MSH2 P43246 L119R 119 L R 0.994 Pathogenic MSH2 P43246 L119S 119 L S 0.614 Pathogenic MSH2 P43246 L119T 119 L T 0.59 Pathogenic MSH2 P43246 L119V 119 L V 0.072 Neutral MSH2 P43246 L119W 119 L W 0.94 Pathogenic MSH2 P43246 L119Y 119 L Y 0.902 Pathogenic MSH2 P43246 E12A 12 E A 0.504 Pathogenic MSH2 P43246 E12C 12 E C 0.388 Neutral MSH2 P43246 E12D 12 E D 0.014 Neutral MSH2 P43246 E12F 12 E F 0.782 Pathogenic MSH2 P43246 E12G 12 E G 0.024 Neutral MSH2 P43246 E12H 12 E H 0.536 Pathogenic MSH2 P43246 E12I 12 E I 0.836 Pathogenic MSH2 P43246 E12K 12 E K 0.662 Pathogenic MSH2 P43246 E12L 12 E L 0.822 Pathogenic MSH2 P43246 E12M 12 E M 0.636 Pathogenic MSH2 P43246 E12N 12 E N 0.264 Neutral MSH2 P43246 E12P 12 E P 0.842 Pathogenic MSH2 P43246 E12Q 12 E Q 0.264 Neutral MSH2 P43246 E12R 12 E R 0.416 Neutral MSH2 P43246 E12S 12 E S 0.262 Neutral MSH2 P43246 E12T 12 E T 0.568 Pathogenic MSH2 P43246 E12V 12 E V 0.772 Pathogenic MSH2 P43246 E12W 12 E W 0.918 Pathogenic MSH2 P43246 E12Y 12 E Y 0.88 Pathogenic MSH2 P43246 A120C 120 A C 0.652 Pathogenic MSH2 P43246 A120D 120 A D 0.628 Pathogenic MSH2 P43246 A120E 120 A E 0.552 Pathogenic MSH2 P43246 A120F 120 A F 0.934 Pathogenic MSH2 P43246 A120G 120 A G 0.024 Neutral MSH2 P43246 A120H 120 A H 0.822 Pathogenic MSH2 P43246 A120I 120 A I 0.59 Pathogenic MSH2 P43246 A120K 120 A K 0.7 Pathogenic MSH2 P43246 A120L 120 A L 0.554 Pathogenic MSH2 P43246 A120M 120 A M 0.79 Pathogenic MSH2 P43246 A120N 120 A N 0.732 Pathogenic MSH2 P43246 A120P 120 A P 0.816 Pathogenic MSH2 P43246 A120Q 120 A Q 0.482 Neutral MSH2 P43246 A120R 120 A R 0.878 Pathogenic MSH2 P43246 A120S 120 A S 0.012 Neutral MSH2 P43246 A120T 120 A T 0.038 Neutral MSH2 P43246 A120V 120 A V 0.122 Neutral MSH2 P43246 A120W 120 A W 0.926 Pathogenic MSH2 P43246 A120Y 120 A Y 0.916 Pathogenic MSH2 P43246 Y121A 121 Y A 0.23 Neutral MSH2 P43246 Y121C 121 Y C 0.286 Neutral MSH2 P43246 Y121D 121 Y D 0.788 Pathogenic MSH2 P43246 Y121E 121 Y E 0.482 Neutral MSH2 P43246 Y121F 121 Y F 0.082 Neutral MSH2 P43246 Y121G 121 Y G 0.258 Neutral MSH2 P43246 Y121H 121 Y H 0.208 Neutral MSH2 P43246 Y121I 121 Y I 0.258 Neutral MSH2 P43246 Y121K 121 Y K 0.278 Neutral MSH2 P43246 Y121L 121 Y L 0.15 Neutral MSH2 P43246 Y121M 121 Y M 0.564 Pathogenic MSH2 P43246 Y121N 121 Y N 0.352 Neutral MSH2 P43246 Y121P 121 Y P 0.63 Pathogenic MSH2 P43246 Y121Q 121 Y Q 0.522 Pathogenic MSH2 P43246 Y121R 121 Y R 0.174 Neutral MSH2 P43246 Y121S 121 Y S 0.372 Neutral MSH2 P43246 Y121T 121 Y T 0.514 Pathogenic MSH2 P43246 Y121V 121 Y V 0.168 Neutral MSH2 P43246 Y121W 121 Y W 0.682 Pathogenic MSH2 P43246 K122A 122 K A 0.088 Neutral MSH2 P43246 K122C 122 K C 0.206 Neutral MSH2 P43246 K122D 122 K D 0.32 Neutral MSH2 P43246 K122E 122 K E 0.024 Neutral MSH2 P43246 K122F 122 K F 0.77 Pathogenic MSH2 P43246 K122G 122 K G 0.36 Neutral MSH2 P43246 K122H 122 K H 0.068 Neutral MSH2 P43246 K122I 122 K I 0.894 Pathogenic MSH2 P43246 K122L 122 K L 0.67 Pathogenic MSH2 P43246 K122M 122 K M 0.548 Pathogenic MSH2 P43246 K122N 122 K N 0.06 Neutral MSH2 P43246 K122P 122 K P 0.832 Pathogenic MSH2 P43246 K122Q 122 K Q 0.026 Neutral MSH2 P43246 K122R 122 K R 0.042 Neutral MSH2 P43246 K122S 122 K S 0.028 Neutral MSH2 P43246 K122T 122 K T 0.044 Neutral MSH2 P43246 K122V 122 K V 0.63 Pathogenic MSH2 P43246 K122W 122 K W 0.976 Pathogenic MSH2 P43246 K122Y 122 K Y 0.93 Pathogenic MSH2 P43246 A123C 123 A C 0.896 Pathogenic MSH2 P43246 A123D 123 A D 0.922 Pathogenic MSH2 P43246 A123E 123 A E 0.902 Pathogenic MSH2 P43246 A123F 123 A F 0.966 Pathogenic MSH2 P43246 A123G 123 A G 0.092 Neutral MSH2 P43246 A123H 123 A H 0.886 Pathogenic MSH2 P43246 A123I 123 A I 0.956 Pathogenic MSH2 P43246 A123K 123 A K 0.81 Pathogenic MSH2 P43246 A123L 123 A L 0.98 Pathogenic MSH2 P43246 A123M 123 A M 0.864 Pathogenic MSH2 P43246 A123N 123 A N 0.846 Pathogenic MSH2 P43246 A123P 123 A P 0.968 Pathogenic MSH2 P43246 A123Q 123 A Q 0.834 Pathogenic MSH2 P43246 A123R 123 A R 0.96 Pathogenic MSH2 P43246 A123S 123 A S 0.47 Neutral MSH2 P43246 A123T 123 A T 0.76 Pathogenic MSH2 P43246 A123V 123 A V 0.782 Pathogenic MSH2 P43246 A123W 123 A W 0.976 Pathogenic MSH2 P43246 A123Y 123 A Y 0.96 Pathogenic MSH2 P43246 S124A 124 S A 0.852 Pathogenic MSH2 P43246 S124C 124 S C 0.894 Pathogenic MSH2 P43246 S124D 124 S D 0.906 Pathogenic MSH2 P43246 S124E 124 S E 0.958 Pathogenic MSH2 P43246 S124F 124 S F 0.978 Pathogenic MSH2 P43246 S124G 124 S G 0.688 Pathogenic MSH2 P43246 S124H 124 S H 0.97 Pathogenic MSH2 P43246 S124I 124 S I 0.784 Pathogenic MSH2 P43246 S124K 124 S K 0.726 Pathogenic MSH2 P43246 S124L 124 S L 0.92 Pathogenic MSH2 P43246 S124M 124 S M 0.994 Pathogenic MSH2 P43246 S124N 124 S N 0.888 Pathogenic MSH2 P43246 S124P 124 S P 0.962 Pathogenic MSH2 P43246 S124Q 124 S Q 0.948 Pathogenic MSH2 P43246 S124R 124 S R 0.968 Pathogenic MSH2 P43246 S124T 124 S T 0.266 Neutral MSH2 P43246 S124V 124 S V 0.94 Pathogenic MSH2 P43246 S124W 124 S W 0.942 Pathogenic MSH2 P43246 S124Y 124 S Y 0.948 Pathogenic MSH2 P43246 P125A 125 P A 0.828 Pathogenic MSH2 P43246 P125C 125 P C 0.912 Pathogenic MSH2 P43246 P125D 125 P D 0.864 Pathogenic MSH2 P43246 P125E 125 P E 0.954 Pathogenic MSH2 P43246 P125F 125 P F 0.998 Pathogenic MSH2 P43246 P125G 125 P G 0.69 Pathogenic MSH2 P43246 P125H 125 P H 0.974 Pathogenic MSH2 P43246 P125I 125 P I 0.936 Pathogenic MSH2 P43246 P125K 125 P K 0.944 Pathogenic MSH2 P43246 P125L 125 P L 0.892 Pathogenic MSH2 P43246 P125M 125 P M 0.954 Pathogenic MSH2 P43246 P125N 125 P N 0.784 Pathogenic MSH2 P43246 P125Q 125 P Q 0.876 Pathogenic MSH2 P43246 P125R 125 P R 0.784 Pathogenic MSH2 P43246 P125S 125 P S 0.344 Neutral MSH2 P43246 P125T 125 P T 0.734 Pathogenic MSH2 P43246 P125V 125 P V 0.838 Pathogenic MSH2 P43246 P125W 125 P W 0.93 Pathogenic MSH2 P43246 P125Y 125 P Y 0.926 Pathogenic MSH2 P43246 G126A 126 G A 0.964 Pathogenic MSH2 P43246 G126C 126 G C 0.946 Pathogenic MSH2 P43246 G126D 126 G D 0.998 Pathogenic MSH2 P43246 G126E 126 G E 0.986 Pathogenic MSH2 P43246 G126F 126 G F 0.98 Pathogenic MSH2 P43246 G126H 126 G H 0.984 Pathogenic MSH2 P43246 G126I 126 G I 0.97 Pathogenic MSH2 P43246 G126K 126 G K 0.926 Pathogenic MSH2 P43246 G126L 126 G L 0.98 Pathogenic MSH2 P43246 G126M 126 G M 0.992 Pathogenic MSH2 P43246 G126N 126 G N 0.984 Pathogenic MSH2 P43246 G126P 126 G P 0.962 Pathogenic MSH2 P43246 G126Q 126 G Q 0.992 Pathogenic MSH2 P43246 G126R 126 G R 0.998 Pathogenic MSH2 P43246 G126S 126 G S 0.824 Pathogenic MSH2 P43246 G126T 126 G T 0.838 Pathogenic MSH2 P43246 G126V 126 G V 0.982 Pathogenic MSH2 P43246 G126W 126 G W 0.976 Pathogenic MSH2 P43246 G126Y 126 G Y 0.956 Pathogenic MSH2 P43246 N127A 127 N A 0.78 Pathogenic MSH2 P43246 N127C 127 N C 0.73 Pathogenic MSH2 P43246 N127D 127 N D 0.664 Pathogenic MSH2 P43246 N127E 127 N E 0.546 Pathogenic MSH2 P43246 N127F 127 N F 0.946 Pathogenic MSH2 P43246 N127G 127 N G 0.68 Pathogenic MSH2 P43246 N127H 127 N H 0.742 Pathogenic MSH2 P43246 N127I 127 N I 0.932 Pathogenic MSH2 P43246 N127K 127 N K 0.412 Neutral MSH2 P43246 N127L 127 N L 0.94 Pathogenic MSH2 P43246 N127M 127 N M 0.942 Pathogenic MSH2 P43246 N127P 127 N P 0.834 Pathogenic MSH2 P43246 N127Q 127 N Q 0.732 Pathogenic MSH2 P43246 N127R 127 N R 0.726 Pathogenic MSH2 P43246 N127S 127 N S 0.204 Neutral 1 MSH2 P43246 N127T 127 N T 0.464 Neutral MSH2 P43246 N127V 127 N V 0.75 Pathogenic MSH2 P43246 N127W 127 N W 0.962 Pathogenic MSH2 P43246 N127Y 127 N Y 0.794 Pathogenic MSH2 P43246 L128A 128 L A 0.708 Pathogenic MSH2 P43246 L128C 128 L C 0.82 Pathogenic MSH2 P43246 L128D 128 L D 0.888 Pathogenic MSH2 P43246 L128E 128 L E 0.868 Pathogenic MSH2 P43246 L128F 128 L F 0.624 Pathogenic MSH2 P43246 L128G 128 L G 0.85 Pathogenic MSH2 P43246 L128H 128 L H 0.91 Pathogenic MSH2 P43246 L128I 128 L I 0.218 Neutral MSH2 P43246 L128K 128 L K 0.384 Neutral MSH2 P43246 L128M 128 L M 0.65 Pathogenic MSH2 P43246 L128N 128 L N 0.782 Pathogenic MSH2 P43246 L128P 128 L P 0.992 Pathogenic MSH2 P43246 L128Q 128 L Q 0.746 Pathogenic MSH2 P43246 L128R 128 L R 0.98 Pathogenic MSH2 P43246 L128S 128 L S 0.674 Pathogenic MSH2 P43246 L128T 128 L T 0.116 Neutral MSH2 P43246 L128V 128 L V 0.072 Neutral MSH2 P43246 L128W 128 L W 0.878 Pathogenic MSH2 P43246 L128Y 128 L Y 0.876 Pathogenic MSH2 P43246 S129A 129 S A 0.05 Neutral MSH2 P43246 S129C 129 S C 0.454 Neutral MSH2 P43246 S129D 129 S D 0.272 Neutral MSH2 P43246 S129E 129 S E 0.45 Neutral MSH2 P43246 S129F 129 S F 0.796 Pathogenic MSH2 P43246 S129G 129 S G 0.02 Neutral MSH2 P43246 S129H 129 S H 0.674 Pathogenic MSH2 P43246 S129I 129 S I 0.47 Neutral MSH2 P43246 S129K 129 S K 0.738 Pathogenic MSH2 P43246 S129L 129 S L 0.172 Neutral MSH2 P43246 S129M 129 S M 0.976 Pathogenic MSH2 P43246 S129N 129 S N 0.056 Neutral MSH2 P43246 S129P 129 S P 0.6 Pathogenic MSH2 P43246 S129Q 129 S Q 0.492 Neutral MSH2 P43246 S129R 129 S R 0.586 Pathogenic MSH2 P43246 S129T 129 S T 0.054 Neutral MSH2 P43246 S129V 129 S V 0.786 Pathogenic MSH2 P43246 S129W 129 S W 0.952 Pathogenic MSH2 P43246 S129Y 129 S Y 0.932 Pathogenic MSH2 P43246 S13A 13 S A 0.01 Neutral MSH2 P43246 S13C 13 S C 0.032 Neutral MSH2 P43246 S13D 13 S D 0.026 Neutral MSH2 P43246 S13E 13 S E 0.168 Neutral MSH2 P43246 S13F 13 S F 0.268 Neutral MSH2 P43246 S13G 13 S G 0 Neutral MSH2 P43246 S13H 13 S H 0.214 Neutral MSH2 P43246 S13I 13 S I 0.198 Neutral MSH2 P43246 S13K 13 S K 0.172 Neutral MSH2 P43246 S13L 13 S L 0.066 Neutral MSH2 P43246 S13M 13 S M 0.382 Neutral MSH2 P43246 S13N 13 S N 0 Neutral MSH2 P43246 S13P 13 S P 0.062 Neutral MSH2 P43246 S13Q 13 S Q 0.178 Neutral MSH2 P43246 S13R 13 S R 0.168 Neutral MSH2 P43246 S13T 13 S T 0.02 Neutral MSH2 P43246 S13V 13 S V 0.036 Neutral MSH2 P43246 S13W 13 S W 0.516 Pathogenic MSH2 P43246 S13Y 13 S Y 0.486 Neutral MSH2 P43246 Q130A 130 Q A 0.116 Neutral MSH2 P43246 Q130C 130 Q C 0.31 Neutral MSH2 P43246 Q130D 130 Q D 0.026 Neutral MSH2 P43246 Q130E 130 Q E 0.034 Neutral MSH2 P43246 Q130F 130 Q F 0.842 Pathogenic MSH2 P43246 Q130G 130 Q G 0.416 Neutral MSH2 P43246 Q130H 130 Q H 0.088 Neutral MSH2 P43246 Q130I 130 Q I 0.896 Pathogenic MSH2 P43246 Q130K 130 Q K 0.788 Pathogenic MSH2 P43246 Q130L 130 Q L 0.204 Neutral MSH2 P43246 Q130M 130 Q M 0.2 Neutral MSH2 P43246 Q130N 130 Q N 0.588 Pathogenic MSH2 P43246 Q130P 130 Q P 0.324 Neutral MSH2 P43246 Q130R 130 Q R 0.568 Pathogenic MSH2 P43246 Q130S 130 Q S 0.084 Neutral MSH2 P43246 Q130T 130 Q T 0.524 Pathogenic MSH2 P43246 Q130V 130 Q V 0.848 Pathogenic MSH2 P43246 Q130W 130 Q W 0.932 Pathogenic MSH2 P43246 Q130Y 130 Q Y 0.894 Pathogenic MSH2 P43246 F131A 131 F A 0.416 Neutral MSH2 P43246 F131C 131 F C 0.584 Pathogenic MSH2 P43246 F131D 131 F D 0.808 Pathogenic MSH2 P43246 F131E 131 F E 0.888 Pathogenic MSH2 P43246 F131G 131 F G 0.486 Neutral MSH2 P43246 F131H 131 F H 0.652 Pathogenic MSH2 P43246 F131I 131 F I 0.118 Neutral MSH2 P43246 F131K 131 F K 0.866 Pathogenic MSH2 P43246 F131L 131 F L 0.078 Neutral MSH2 P43246 F131M 131 F M 0.122 Neutral MSH2 P43246 F131N 131 F N 0.726 Pathogenic MSH2 P43246 F131P 131 F P 0.934 Pathogenic MSH2 P43246 F131Q 131 F Q 0.758 Pathogenic MSH2 P43246 F131R 131 F R 0.928 Pathogenic MSH2 P43246 F131S 131 F S 0.162 Neutral MSH2 P43246 F131T 131 F T 0.58 Pathogenic MSH2 P43246 F131V 131 F V 0.234 Neutral MSH2 P43246 F131W 131 F W 0.93 Pathogenic MSH2 P43246 F131Y 131 F Y 0.576 Pathogenic MSH2 P43246 E132A 132 E A 0.476 Neutral MSH2 P43246 E132C 132 E C 0.738 Pathogenic MSH2 P43246 E132D 132 E D 0.878 Pathogenic MSH2 P43246 E132F 132 E F 0.946 Pathogenic MSH2 P43246 E132G 132 E G 0.334 Neutral MSH2 P43246 E132H 132 E H 0.684 Pathogenic MSH2 P43246 E132I 132 E I 0.972 Pathogenic MSH2 P43246 E132K 132 E K 0.872 Pathogenic MSH2 P43246 E132L 132 E L 0.958 Pathogenic MSH2 P43246 E132M 132 E M 0.888 Pathogenic MSH2 P43246 E132N 132 E N 0.334 Neutral MSH2 P43246 E132P 132 E P 0.924 Pathogenic MSH2 P43246 E132Q 132 E Q 0.202 Neutral MSH2 P43246 E132R 132 E R 0.602 Pathogenic MSH2 P43246 E132S 132 E S 0.856 Pathogenic MSH2 P43246 E132T 132 E T 0.35 Neutral MSH2 P43246 E132V 132 E V 0.908 Pathogenic MSH2 P43246 E132W 132 E W 0.974 Pathogenic MSH2 P43246 E132Y 132 E Y 0.95 Pathogenic MSH2 P43246 D133A 133 D A 0.484 Neutral MSH2 P43246 D133C 133 D C 0.726 Pathogenic MSH2 P43246 D133E 133 D E 0.04 Neutral MSH2 P43246 D133F 133 D F 0.404 Neutral MSH2 P43246 D133G 133 D G 0.476 Neutral MSH2 P43246 D133H 133 D H 0.332 Neutral MSH2 P43246 D133I 133 D I 0.18 Neutral MSH2 P43246 D133K 133 D K 0.732 Pathogenic MSH2 P43246 D133L 133 D L 0.088 Neutral MSH2 P43246 D133M 133 D M 0.104 Neutral MSH2 P43246 D133N 133 D N 0.306 Neutral MSH2 P43246 D133P 133 D P 0.8 Pathogenic MSH2 P43246 D133Q 133 D Q 0.474 Neutral MSH2 P43246 D133R 133 D R 0.62 Pathogenic MSH2 P43246 D133S 133 D S 0.49 Neutral MSH2 P43246 D133T 133 D T 0.132 Neutral MSH2 P43246 D133V 133 D V 0.118 Neutral MSH2 P43246 D133W 133 D W 0.97 Pathogenic MSH2 P43246 D133Y 133 D Y 0.964 Pathogenic MSH2 P43246 I134A 134 I A 0.624 Pathogenic MSH2 P43246 I134C 134 I C 0.7 Pathogenic MSH2 P43246 I134D 134 I D 0.178 Neutral MSH2 P43246 I134E 134 I E 0.768 Pathogenic MSH2 P43246 I134F 134 I F 0.336 Neutral MSH2 P43246 I134G 134 I G 0.852 Pathogenic MSH2 P43246 I134H 134 I H 0.892 Pathogenic MSH2 P43246 I134K 134 I K 0.824 Pathogenic MSH2 P43246 I134L 134 I L 0.162 Neutral MSH2 P43246 I134M 134 I M 0.34 Neutral MSH2 P43246 I134N 134 I N 0.79 Pathogenic MSH2 P43246 I134P 134 I P 0.904 Pathogenic MSH2 P43246 I134Q 134 I Q 0.798 Pathogenic MSH2 P43246 I134R 134 I R 0.874 Pathogenic MSH2 P43246 I134S 134 I S 0.672 Pathogenic MSH2 P43246 I134T 134 I T 0.268 Neutral MSH2 P43246 I134V 134 I V 0.16 Neutral MSH2 P43246 I134W 134 I W 0.866 Pathogenic MSH2 P43246 I134Y 134 I Y 0.842 Pathogenic MSH2 P43246 L135A 135 L A 0.122 Neutral MSH2 P43246 L135C 135 L C 0.686 Pathogenic MSH2 P43246 L135D 135 L D 0.912 Pathogenic MSH2 P43246 L135E 135 L E 0.89 Pathogenic MSH2 P43246 L135F 135 L F 0.54 Pathogenic MSH2 P43246 L135G 135 L G 0.202 Neutral MSH2 P43246 L135H 135 L H 0.782 Pathogenic MSH2 P43246 L135I 135 L I 0.174 Neutral MSH2 P43246 L135K 135 L K 0.41 Neutral MSH2 P43246 L135M 135 L M 0.176 Neutral MSH2 P43246 L135N 135 L N 0.782 Pathogenic MSH2 P43246 L135P 135 L P 0.978 Pathogenic MSH2 P43246 L135Q 135 L Q 0.612 Pathogenic MSH2 P43246 L135R 135 L R 0.996 Pathogenic MSH2 P43246 L135S 135 L S 0.6 Pathogenic MSH2 P43246 L135T 135 L T 0.58 Pathogenic MSH2 P43246 L135V 135 L V 0.55 Pathogenic MSH2 P43246 L135W 135 L W 0.908 Pathogenic MSH2 P43246 L135Y 135 L Y 0.658 Pathogenic MSH2 P43246 F136A 136 F A 0.154 Neutral MSH2 P43246 F136C 136 F C 0.274 Neutral MSH2 P43246 F136D 136 F D 0.158 Neutral MSH2 P43246 F136E 136 F E 0.188 Neutral MSH2 P43246 F136G 136 F G 0.138 Neutral MSH2 P43246 F136H 136 F H 0.268 Neutral MSH2 P43246 F136I 136 F I 0.376 Neutral MSH2 P43246 F136K 136 F K 0.12 Neutral MSH2 P43246 F136L 136 F L 0.066 Neutral MSH2 P43246 F136M 136 F M 0.282 Neutral MSH2 P43246 F136N 136 F N 0.098 Neutral MSH2 P43246 F136P 136 F P 0.684 Pathogenic MSH2 P43246 F136Q 136 F Q 0.562 Pathogenic MSH2 P43246 F136R 136 F R 0.114 Neutral MSH2 P43246 F136S 136 F S 0.082 Neutral MSH2 P43246 F136T 136 F T 0.074 Neutral MSH2 P43246 F136V 136 F V 0.044 Neutral MSH2 P43246 F136W 136 F W 0.812 Pathogenic MSH2 P43246 F136Y 136 F Y 0.51 Pathogenic MSH2 P43246 G137A 137 G A 0.114 Neutral MSH2 P43246 G137C 137 G C 0.762 Pathogenic MSH2 P43246 G137D 137 G D 0.472 Neutral MSH2 P43246 G137E 137 G E 0.94 Pathogenic MSH2 P43246 G137F 137 G F 0.668 Pathogenic MSH2 P43246 G137H 137 G H 0.628 Pathogenic MSH2 P43246 G137I 137 G I 0.708 Pathogenic MSH2 P43246 G137K 137 G K 0.946 Pathogenic MSH2 P43246 G137L 137 G L 0.948 Pathogenic MSH2 P43246 G137M 137 G M 0.936 Pathogenic MSH2 P43246 G137N 137 G N 0.488 Neutral MSH2 P43246 G137P 137 G P 0.936 Pathogenic MSH2 P43246 G137Q 137 G Q 0.538 Pathogenic MSH2 P43246 G137R 137 G R 0.978 Pathogenic MSH2 P43246 G137S 137 G S 0.106 Neutral MSH2 P43246 G137T 137 G T 0.738 Pathogenic MSH2 P43246 G137V 137 G V 0.628 Pathogenic MSH2 P43246 G137W 137 G W 0.954 Pathogenic MSH2 P43246 G137Y 137 G Y 0.814 Pathogenic MSH2 P43246 N138A 138 N A 0.014 Neutral MSH2 P43246 N138C 138 N C 0.254 Neutral MSH2 P43246 N138D 138 N D 0.19 Neutral MSH2 P43246 N138E 138 N E 0.026 Neutral MSH2 P43246 N138F 138 N F 0.58 Pathogenic MSH2 P43246 N138G 138 N G 0.026 Neutral MSH2 P43246 N138H 138 N H 0.358 Neutral MSH2 P43246 N138I 138 N I 0.274 Neutral MSH2 P43246 N138K 138 N K 0.404 Neutral MSH2 P43246 N138L 138 N L 0.158 Neutral MSH2 P43246 N138M 138 N M 0.106 Neutral MSH2 P43246 N138P 138 N P 0.386 Neutral MSH2 P43246 N138Q 138 N Q 0.184 Neutral MSH2 P43246 N138R 138 N R 0.26 Neutral MSH2 P43246 N138S 138 N S 0.01 Neutral MSH2 P43246 N138T 138 N T 0.014 Neutral MSH2 P43246 N138V 138 N V 0.05 Neutral MSH2 P43246 N138W 138 N W 0.706 Pathogenic MSH2 P43246 N138Y 138 N Y 0.664 Pathogenic MSH2 P43246 N139A 139 N A 0.006 Neutral MSH2 P43246 N139C 139 N C 0.244 Neutral MSH2 P43246 N139D 139 N D 0.008 Neutral MSH2 P43246 N139E 139 N E 0.014 Neutral MSH2 P43246 N139F 139 N F 0.588 Pathogenic MSH2 P43246 N139G 139 N G 0.02 Neutral MSH2 P43246 N139H 139 N H 0.174 Neutral MSH2 P43246 N139I 139 N I 0.504 Pathogenic MSH2 P43246 N139K 139 N K 0.366 Neutral MSH2 P43246 N139L 139 N L 0.098 Neutral MSH2 P43246 N139M 139 N M 0.04 Neutral MSH2 P43246 N139P 139 N P 0.28 Neutral MSH2 P43246 N139Q 139 N Q 0.018 Neutral MSH2 P43246 N139R 139 N R 0.358 Neutral MSH2 P43246 N139S 139 N S 0.004 Neutral MSH2 P43246 N139T 139 N T 0.008 Neutral MSH2 P43246 N139V 139 N V 0.044 Neutral MSH2 P43246 N139W 139 N W 0.718 Pathogenic MSH2 P43246 N139Y 139 N Y 0.672 Pathogenic MSH2 P43246 A14C 14 A C 0.22 Neutral MSH2 P43246 A14D 14 A D 0.386 Neutral MSH2 P43246 A14E 14 A E 0.352 Neutral MSH2 P43246 A14F 14 A F 0.54 Pathogenic MSH2 P43246 A14G 14 A G 0.006 Neutral MSH2 P43246 A14H 14 A H 0.366 Neutral MSH2 P43246 A14I 14 A I 0.442 Neutral MSH2 P43246 A14K 14 A K 0.298 Neutral MSH2 P43246 A14L 14 A L 0.466 Neutral MSH2 P43246 A14M 14 A M 0.352 Neutral MSH2 P43246 A14N 14 A N 0.336 Neutral MSH2 P43246 A14P 14 A P 0.046 Neutral MSH2 P43246 A14Q 14 A Q 0.284 Neutral MSH2 P43246 A14R 14 A R 0.334 Neutral MSH2 P43246 A14S 14 A S 0.006 Neutral MSH2 P43246 A14T 14 A T 0.022 Neutral MSH2 P43246 A14V 14 A V 0.048 Neutral MSH2 P43246 A14W 14 A W 0.572 Pathogenic MSH2 P43246 A14Y 14 A Y 0.57 Pathogenic MSH2 P43246 D140A 140 D A 0.03 Neutral MSH2 P43246 D140C 140 D C 0.356 Neutral MSH2 P43246 D140E 140 D E 0.022 Neutral MSH2 P43246 D140F 140 D F 0.668 Pathogenic MSH2 P43246 D140G 140 D G 0.032 Neutral MSH2 P43246 D140H 140 D H 0.36 Neutral MSH2 P43246 D140I 140 D I 0.21 Neutral MSH2 P43246 D140K 140 D K 0.482 Neutral MSH2 P43246 D140L 140 D L 0.06 Neutral MSH2 P43246 D140M 140 D M 0.056 Neutral MSH2 P43246 D140N 140 D N 0.004 Neutral MSH2 P43246 D140P 140 D P 0.572 Pathogenic MSH2 P43246 D140Q 140 D Q 0.016 Neutral MSH2 P43246 D140R 140 D R 0.42 Neutral MSH2 P43246 D140S 140 D S 0.012 Neutral MSH2 P43246 D140T 140 D T 0.04 Neutral MSH2 P43246 D140V 140 D V 0.52 Pathogenic MSH2 P43246 D140W 140 D W 0.796 Pathogenic MSH2 P43246 D140Y 140 D Y 0.764 Pathogenic MSH2 P43246 M141A 141 M A 0.106 Neutral MSH2 P43246 M141C 141 M C 0.214 Neutral MSH2 P43246 M141D 141 M D 0.098 Neutral MSH2 P43246 M141E 141 M E 0.03 Neutral MSH2 P43246 M141F 141 M F 0.75 Pathogenic MSH2 P43246 M141G 141 M G 0.082 Neutral MSH2 P43246 M141H 141 M H 0.336 Neutral MSH2 P43246 M141I 141 M I 0.134 Neutral MSH2 P43246 M141K 141 M K 0.068 Neutral MSH2 P43246 M141L 141 M L 0.444 Neutral MSH2 P43246 M141N 141 M N 0.102 Neutral MSH2 P43246 M141P 141 M P 0.464 Neutral MSH2 P43246 M141Q 141 M Q 0.024 Neutral MSH2 P43246 M141R 141 M R 0.602 Pathogenic MSH2 P43246 M141S 141 M S 0.038 Neutral MSH2 P43246 M141T 141 M T 0.082 Neutral MSH2 P43246 M141V 141 M V 0.542 Pathogenic MSH2 P43246 M141W 141 M W 0.91 Pathogenic MSH2 P43246 M141Y 141 M Y 0.838 Pathogenic MSH2 P43246 S142A 142 S A 0.048 Neutral MSH2 P43246 S142C 142 S C 0.458 Neutral MSH2 P43246 S142D 142 S D 0.094 Neutral MSH2 P43246 S142E 142 S E 0.448 Neutral MSH2 P43246 S142F 142 S F 0.884 Pathogenic MSH2 P43246 S142G 142 S G 0.234 Neutral MSH2 P43246 S142H 142 S H 0.8 Pathogenic MSH2 P43246 S142I 142 S I 0.6 Pathogenic MSH2 P43246 S142K 142 S K 0.736 Pathogenic MSH2 P43246 S142L 142 S L 0.528 Pathogenic MSH2 P43246 S142M 142 S M 0.976 Pathogenic MSH2 P43246 S142N 142 S N 0.28 Neutral MSH2 P43246 S142P 142 S P 0.156 Neutral MSH2 P43246 S142Q 142 S Q 0.69 Pathogenic MSH2 P43246 S142R 142 S R 0.684 Pathogenic MSH2 P43246 S142T 142 S T 0.064 Neutral MSH2 P43246 S142V 142 S V 0.12 Neutral MSH2 P43246 S142W 142 S W 0.952 Pathogenic MSH2 P43246 S142Y 142 S Y 0.932 Pathogenic MSH2 P43246 A143C 143 A C 0.412 Neutral MSH2 P43246 A143D 143 A D 0.5 Pathogenic MSH2 P43246 A143E 143 A E 0.5 Pathogenic MSH2 P43246 A143F 143 A F 0.782 Pathogenic MSH2 P43246 A143G 143 A G 0.006 Neutral MSH2 P43246 A143H 143 A H 0.582 Pathogenic MSH2 P43246 A143I 143 A I 0.514 Pathogenic MSH2 P43246 A143K 143 A K 0.654 Pathogenic MSH2 P43246 A143L 143 A L 0.744 Pathogenic MSH2 P43246 A143M 143 A M 0.398 Neutral MSH2 P43246 A143N 143 A N 0.528 Pathogenic MSH2 P43246 A143P 143 A P 0.08 Neutral MSH2 P43246 A143Q 143 A Q 0.464 Neutral MSH2 P43246 A143R 143 A R 0.652 Pathogenic MSH2 P43246 A143S 143 A S 0.008 Neutral MSH2 P43246 A143T 143 A T 0.024 Neutral MSH2 P43246 A143V 143 A V 0.056 Neutral MSH2 P43246 A143W 143 A W 0.81 Pathogenic MSH2 P43246 A143Y 143 A Y 0.81 Pathogenic MSH2 P43246 S144A 144 S A 0.014 Neutral MSH2 P43246 S144C 144 S C 0.006 Neutral MSH2 P43246 S144D 144 S D 0.076 Neutral MSH2 P43246 S144E 144 S E 0.258 Neutral MSH2 P43246 S144F 144 S F 0.486 Neutral MSH2 P43246 S144G 144 S G 0.108 Neutral MSH2 P43246 S144H 144 S H 0.416 Neutral MSH2 P43246 S144I 144 S I 0.212 Neutral MSH2 P43246 S144K 144 S K 0.344 Neutral MSH2 P43246 S144L 144 S L 0.05 Neutral MSH2 P43246 S144M 144 S M 0.404 Neutral MSH2 P43246 S144N 144 S N 0.056 Neutral MSH2 P43246 S144P 144 S P 0.074 Neutral MSH2 P43246 S144Q 144 S Q 0.306 Neutral MSH2 P43246 S144R 144 S R 0.42 Neutral MSH2 P43246 S144T 144 S T 0.134 Neutral MSH2 P43246 S144V 144 S V 0.044 Neutral MSH2 P43246 S144W 144 S W 0.704 Pathogenic MSH2 P43246 S144Y 144 S Y 0.666 Pathogenic MSH2 P43246 I145A 145 I A 0.006 Neutral MSH2 P43246 I145C 145 I C 0.096 Neutral MSH2 P43246 I145D 145 I D 0.168 Neutral MSH2 P43246 I145E 145 I E 0.17 Neutral MSH2 P43246 I145F 145 I F 0.296 Neutral MSH2 P43246 I145G 145 I G 0.194 Neutral MSH2 P43246 I145H 145 I H 0.104 Neutral MSH2 P43246 I145K 145 I K 0.178 Neutral MSH2 P43246 I145L 145 I L 0.122 Neutral MSH2 P43246 I145M 145 I M 0.126 Neutral MSH2 P43246 I145N 145 I N 0.166 Neutral MSH2 P43246 I145P 145 I P 0.068 Neutral MSH2 P43246 I145Q 145 I Q 0.206 Neutral MSH2 P43246 I145R 145 I R 0.4 Neutral MSH2 P43246 I145S 145 I S 0.072 Neutral MSH2 P43246 I145T 145 I T 0.002 Neutral MSH2 P43246 I145V 145 I V 0 Neutral MSH2 P43246 I145W 145 I W 0.464 Neutral MSH2 P43246 I145Y 145 I Y 0.42 Neutral MSH2 P43246 G146A 146 G A 0.16 Neutral MSH2 P43246 G146C 146 G C 0.34 Neutral MSH2 P43246 G146D 146 G D 0.248 Neutral MSH2 P43246 G146E 146 G E 0.342 Neutral MSH2 P43246 G146F 146 G F 0.758 Pathogenic MSH2 P43246 G146H 146 G H 0.7 Pathogenic MSH2 P43246 G146I 146 G I 0.516 Pathogenic MSH2 P43246 G146K 146 G K 0.682 Pathogenic MSH2 P43246 G146L 146 G L 0.674 Pathogenic MSH2 P43246 G146M 146 G M 0.69 Pathogenic MSH2 P43246 G146N 146 G N 0.332 Neutral MSH2 P43246 G146P 146 G P 0.684 Pathogenic MSH2 P43246 G146Q 146 G Q 0.364 Neutral MSH2 P43246 G146R 146 G R 0.75 Pathogenic MSH2 P43246 G146S 146 G S 0.03 Neutral MSH2 P43246 G146T 146 G T 0.408 Neutral MSH2 P43246 G146V 146 G V 0.444 Neutral MSH2 P43246 G146W 146 G W 0.758 Pathogenic MSH2 P43246 G146Y 146 G Y 0.744 Pathogenic MSH2 P43246 V147A 147 V A 0.104 Neutral MSH2 P43246 V147C 147 V C 0.712 Pathogenic MSH2 P43246 V147D 147 V D 0.868 Pathogenic MSH2 P43246 V147E 147 V E 0.982 Pathogenic MSH2 P43246 V147F 147 V F 0.872 Pathogenic MSH2 P43246 V147G 147 V G 0.482 Neutral MSH2 P43246 V147H 147 V H 0.814 Pathogenic MSH2 P43246 V147I 147 V I 0.152 Neutral MSH2 P43246 V147K 147 V K 0.974 Pathogenic MSH2 P43246 V147L 147 V L 0.23 Neutral MSH2 P43246 V147M 147 V M 0.238 Neutral MSH2 P43246 V147N 147 V N 0.934 Pathogenic MSH2 P43246 V147P 147 V P 0.974 Pathogenic MSH2 P43246 V147Q 147 V Q 0.992 Pathogenic MSH2 P43246 V147R 147 V R 0.96 Pathogenic MSH2 P43246 V147S 147 V S 0.15 Neutral MSH2 P43246 V147T 147 V T 0.12 Neutral MSH2 P43246 V147W 147 V W 0.902 Pathogenic MSH2 P43246 V147Y 147 V Y 0.928 Pathogenic MSH2 P43246 V148A 148 V A 0.02 Neutral MSH2 P43246 V148C 148 V C 0.108 Neutral MSH2 P43246 V148D 148 V D 0.6 Pathogenic MSH2 P43246 V148E 148 V E 0.702 Pathogenic MSH2 P43246 V148F 148 V F 0.764 Pathogenic MSH2 P43246 V148G 148 V G 0.614 Pathogenic MSH2 P43246 V148H 148 V H 0.556 Pathogenic MSH2 P43246 V148I 148 V I 0.066 Neutral MSH2 P43246 V148K 148 V K 0.772 Pathogenic MSH2 P43246 V148L 148 V L 0.062 Neutral MSH2 P43246 V148M 148 V M 0.086 Neutral MSH2 P43246 V148N 148 V N 0.644 Pathogenic MSH2 P43246 V148P 148 V P 0.826 Pathogenic MSH2 P43246 V148Q 148 V Q 0.722 Pathogenic MSH2 P43246 V148R 148 V R 0.824 Pathogenic MSH2 P43246 V148S 148 V S 0.26 Neutral MSH2 P43246 V148T 148 V T 0.426 Neutral MSH2 P43246 V148W 148 V W 0.84 Pathogenic MSH2 P43246 V148Y 148 V Y 0.832 Pathogenic MSH2 P43246 G149A 149 G A 0.296 Neutral MSH2 P43246 G149C 149 G C 0.77 Pathogenic MSH2 P43246 G149D 149 G D 0.974 Pathogenic MSH2 P43246 G149E 149 G E 0.984 Pathogenic MSH2 P43246 G149F 149 G F 0.988 Pathogenic MSH2 P43246 G149H 149 G H 0.992 Pathogenic MSH2 P43246 G149I 149 G I 0.79 Pathogenic MSH2 P43246 G149K 149 G K 0.992 Pathogenic MSH2 P43246 G149L 149 G L 0.758 Pathogenic MSH2 P43246 G149M 149 G M 0.994 Pathogenic MSH2 P43246 G149N 149 G N 0.938 Pathogenic MSH2 P43246 G149P 149 G P 0.982 Pathogenic MSH2 P43246 G149Q 149 G Q 0.978 Pathogenic MSH2 P43246 G149R 149 G R 1 Pathogenic MSH2 P43246 G149S 149 G S 0.294 Neutral MSH2 P43246 G149T 149 G T 0.92 Pathogenic MSH2 P43246 G149V 149 G V 0.99 Pathogenic MSH2 P43246 G149W 149 G W 0.984 Pathogenic MSH2 P43246 G149Y 149 G Y 0.984 Pathogenic MSH2 P43246 A15C 15 A C 0.32 Neutral MSH2 P43246 A15D 15 A D 0.472 Neutral MSH2 P43246 A15E 15 A E 0.374 Neutral MSH2 P43246 A15F 15 A F 0.716 Pathogenic MSH2 P43246 A15G 15 A G 0.008 Neutral MSH2 P43246 A15H 15 A H 0.39 Neutral MSH2 P43246 A15I 15 A I 0.66 Pathogenic MSH2 P43246 A15K 15 A K 0.582 Pathogenic MSH2 P43246 A15L 15 A L 0.644 Pathogenic MSH2 P43246 A15M 15 A M 0.478 Neutral MSH2 P43246 A15N 15 A N 0.486 Neutral MSH2 P43246 A15P 15 A P 0.454 Neutral MSH2 P43246 A15Q 15 A Q 0.334 Neutral MSH2 P43246 A15R 15 A R 0.576 Pathogenic MSH2 P43246 A15S 15 A S 0.006 Neutral MSH2 P43246 A15T 15 A T 0.028 Neutral MSH2 P43246 A15V 15 A V 0.06 Neutral MSH2 P43246 A15W 15 A W 0.748 Pathogenic MSH2 P43246 A15Y 15 A Y 0.752 Pathogenic MSH2 P43246 V150A 150 V A 0.066 Neutral MSH2 P43246 V150C 150 V C 0.718 Pathogenic MSH2 P43246 V150D 150 V D 0.868 Pathogenic MSH2 P43246 V150E 150 V E 0.986 Pathogenic MSH2 P43246 V150F 150 V F 0.646 Pathogenic MSH2 P43246 V150G 150 V G 0.902 Pathogenic MSH2 P43246 V150H 150 V H 0.822 Pathogenic MSH2 P43246 V150I 150 V I 0.166 Neutral MSH2 P43246 V150K 150 V K 0.988 Pathogenic MSH2 P43246 V150L 150 V L 0.204 Neutral MSH2 P43246 V150M 150 V M 0.822 Pathogenic MSH2 P43246 V150N 150 V N 0.928 Pathogenic MSH2 P43246 V150P 150 V P 0.984 Pathogenic MSH2 P43246 V150Q 150 V Q 0.992 Pathogenic MSH2 P43246 V150R 150 V R 0.96 Pathogenic MSH2 P43246 V150S 150 V S 0.73 Pathogenic MSH2 P43246 V150T 150 V T 0.752 Pathogenic MSH2 P43246 V150W 150 V W 0.904 Pathogenic MSH2 P43246 V150Y 150 V Y 0.93 Pathogenic MSH2 P43246 K151A 151 K A 0.074 Neutral MSH2 P43246 K151C 151 K C 0.066 Neutral MSH2 P43246 K151D 151 K D 0.34 Neutral MSH2 P43246 K151E 151 K E 0.402 Neutral MSH2 P43246 K151F 151 K F 0.164 Neutral MSH2 P43246 K151G 151 K G 0.354 Neutral MSH2 P43246 K151H 151 K H 0.066 Neutral MSH2 P43246 K151I 151 K I 0.396 Neutral MSH2 P43246 K151L 151 K L 0.134 Neutral MSH2 P43246 K151M 151 K M 0.592 Pathogenic MSH2 P43246 K151N 151 K N 0.1 Neutral MSH2 P43246 K151P 151 K P 0.762 Pathogenic MSH2 P43246 K151Q 151 K Q 0.032 Neutral MSH2 P43246 K151R 151 K R 0.042 Neutral MSH2 P43246 K151S 151 K S 0.034 Neutral MSH2 P43246 K151T 151 K T 0.06 Neutral MSH2 P43246 K151V 151 K V 0.328 Neutral MSH2 P43246 K151W 151 K W 0.606 Pathogenic MSH2 P43246 K151Y 151 K Y 0.884 Pathogenic MSH2 P43246 M152A 152 M A 0.126 Neutral MSH2 P43246 M152C 152 M C 0.218 Neutral MSH2 P43246 M152D 152 M D 0.652 Pathogenic MSH2 P43246 M152E 152 M E 0.402 Neutral MSH2 P43246 M152F 152 M F 0.088 Neutral MSH2 P43246 M152G 152 M G 0.346 Neutral MSH2 P43246 M152H 152 M H 0.46 Neutral MSH2 P43246 M152I 152 M I 0.046 Neutral MSH2 P43246 M152K 152 M K 0.658 Pathogenic MSH2 P43246 M152L 152 M L 0.036 Neutral MSH2 P43246 M152N 152 M N 0.668 Pathogenic MSH2 P43246 M152P 152 M P 0.102 Neutral MSH2 P43246 M152Q 152 M Q 0.32 Neutral MSH2 P43246 M152R 152 M R 0.692 Pathogenic MSH2 P43246 M152S 152 M S 0.432 Neutral MSH2 P43246 M152T 152 M T 0.202 Neutral MSH2 P43246 M152V 152 M V 0.068 Neutral MSH2 P43246 M152W 152 M W 0.96 Pathogenic MSH2 P43246 M152Y 152 M Y 0.214 Neutral MSH2 P43246 S153A 153 S A 0.09 Neutral MSH2 P43246 S153C 153 S C 0.416 Neutral MSH2 P43246 S153D 153 S D 0.38 Neutral MSH2 P43246 S153E 153 S E 0.666 Pathogenic MSH2 P43246 S153F 153 S F 0.83 Pathogenic MSH2 P43246 S153G 153 S G 0.044 Neutral MSH2 P43246 S153H 153 S H 0.588 Pathogenic MSH2 P43246 S153I 153 S I 0.356 Neutral MSH2 P43246 S153K 153 S K 0.44 Neutral MSH2 P43246 S153L 153 S L 0.518 Pathogenic MSH2 P43246 S153M 153 S M 0.892 Pathogenic MSH2 P43246 S153N 153 S N 0.05 Neutral MSH2 P43246 S153P 153 S P 0.568 Pathogenic MSH2 P43246 S153Q 153 S Q 0.446 Neutral MSH2 P43246 S153R 153 S R 0.474 Neutral MSH2 P43246 S153T 153 S T 0.068 Neutral MSH2 P43246 S153V 153 S V 0.124 Neutral MSH2 P43246 S153W 153 S W 0.93 Pathogenic MSH2 P43246 S153Y 153 S Y 0.776 Pathogenic MSH2 P43246 A154C 154 A C 0.658 Pathogenic MSH2 P43246 A154D 154 A D 0.86 Pathogenic MSH2 P43246 A154E 154 A E 0.806 Pathogenic MSH2 P43246 A154F 154 A F 0.516 Pathogenic MSH2 P43246 A154G 154 A G 0.024 Neutral MSH2 P43246 A154H 154 A H 0.654 Pathogenic MSH2 P43246 A154I 154 A I 0.574 Pathogenic MSH2 P43246 A154K 154 A K 0.508 Pathogenic MSH2 P43246 A154L 154 A L 0.532 Pathogenic MSH2 P43246 A154M 154 A M 0.498 Neutral MSH2 P43246 A154N 154 A N 0.644 Pathogenic MSH2 P43246 A154P 154 A P 0.802 Pathogenic MSH2 P43246 A154Q 154 A Q 0.762 Pathogenic MSH2 P43246 A154R 154 A R 0.718 Pathogenic MSH2 P43246 A154S 154 A S 0.016 Neutral MSH2 P43246 A154T 154 A T 0.048 Neutral MSH2 P43246 A154V 154 A V 0.092 Neutral MSH2 P43246 A154W 154 A W 0.918 Pathogenic MSH2 P43246 A154Y 154 A Y 0.74 Pathogenic MSH2 P43246 V155A 155 V A 0.04 Neutral MSH2 P43246 V155C 155 V C 0.284 Neutral MSH2 P43246 V155D 155 V D 0.08 Neutral MSH2 P43246 V155E 155 V E 0.108 Neutral MSH2 P43246 V155F 155 V F 0.378 Neutral MSH2 P43246 V155G 155 V G 0.102 Neutral MSH2 P43246 V155H 155 V H 0.394 Neutral MSH2 P43246 V155I 155 V I 0.298 Neutral MSH2 P43246 V155K 155 V K 0.592 Pathogenic MSH2 P43246 V155L 155 V L 0.078 Neutral MSH2 P43246 V155M 155 V M 0.33 Neutral MSH2 P43246 V155N 155 V N 0.1 Neutral MSH2 P43246 V155P 155 V P 0.084 Neutral MSH2 P43246 V155Q 155 V Q 0.162 Neutral MSH2 P43246 V155R 155 V R 0.732 Pathogenic MSH2 P43246 V155S 155 V S 0.056 Neutral MSH2 P43246 V155T 155 V T 0.04 Neutral MSH2 P43246 V155W 155 V W 0.612 Pathogenic MSH2 P43246 V155Y 155 V Y 0.656 Pathogenic MSH2 P43246 D156A 156 D A 0.028 Neutral MSH2 P43246 D156C 156 D C 0.28 Neutral MSH2 P43246 D156E 156 D E 0.02 Neutral MSH2 P43246 D156F 156 D F 0.632 Pathogenic MSH2 P43246 D156G 156 D G 0.028 Neutral MSH2 P43246 D156H 156 D H 0.168 Neutral MSH2 P43246 D156I 156 D I 0.522 Pathogenic MSH2 P43246 D156K 156 D K 0.084 Neutral MSH2 P43246 D156L 156 D L 0.474 Neutral MSH2 P43246 D156M 156 D M 0.386 Neutral MSH2 P43246 D156N 156 D N 0.002 Neutral MSH2 P43246 D156P 156 D P 0.474 Neutral MSH2 P43246 D156Q 156 D Q 0.306 Neutral MSH2 P43246 D156R 156 D R 0.374 Neutral MSH2 P43246 D156S 156 D S 0.006 Neutral MSH2 P43246 D156T 156 D T 0.03 Neutral MSH2 P43246 D156V 156 D V 0.156 Neutral MSH2 P43246 D156W 156 D W 0.772 Pathogenic MSH2 P43246 D156Y 156 D Y 0.74 Pathogenic MSH2 P43246 G157A 157 G A 0.058 Neutral MSH2 P43246 G157C 157 G C 0.712 Pathogenic MSH2 P43246 G157D 157 G D 0.4 Neutral MSH2 P43246 G157E 157 G E 0.506 Pathogenic MSH2 P43246 G157F 157 G F 0.95 Pathogenic MSH2 P43246 G157H 157 G H 0.92 Pathogenic MSH2 P43246 G157I 157 G I 0.922 Pathogenic MSH2 P43246 G157K 157 G K 0.728 Pathogenic MSH2 P43246 G157L 157 G L 0.926 Pathogenic MSH2 P43246 G157M 157 G M 0.952 Pathogenic MSH2 P43246 G157N 157 G N 0.426 Neutral MSH2 P43246 G157P 157 G P 0.63 Pathogenic MSH2 P43246 G157Q 157 G Q 0.48 Neutral MSH2 P43246 G157R 157 G R 0.968 Pathogenic MSH2 P43246 G157S 157 G S 0.066 Neutral MSH2 P43246 G157T 157 G T 0.688 Pathogenic MSH2 P43246 G157V 157 G V 0.596 Pathogenic MSH2 P43246 G157W 157 G W 0.94 Pathogenic MSH2 P43246 G157Y 157 G Y 0.926 Pathogenic MSH2 P43246 Q158A 158 Q A 0.112 Neutral MSH2 P43246 Q158C 158 Q C 0.386 Neutral MSH2 P43246 Q158D 158 Q D 0.278 Neutral MSH2 P43246 Q158E 158 Q E 0.588 Pathogenic MSH2 P43246 Q158F 158 Q F 0.754 Pathogenic MSH2 P43246 Q158G 158 Q G 0.094 Neutral MSH2 P43246 Q158H 158 Q H 0.72 Pathogenic MSH2 P43246 Q158I 158 Q I 0.796 Pathogenic MSH2 P43246 Q158K 158 Q K 0.044 Neutral MSH2 P43246 Q158L 158 Q L 0.692 Pathogenic MSH2 P43246 Q158M 158 Q M 0.706 Pathogenic MSH2 P43246 Q158N 158 Q N 0.062 Neutral MSH2 P43246 Q158P 158 Q P 0.314 Neutral MSH2 P43246 Q158R 158 Q R 0.038 Neutral MSH2 P43246 Q158S 158 Q S 0.092 Neutral MSH2 P43246 Q158T 158 Q T 0.046 Neutral MSH2 P43246 Q158V 158 Q V 0.414 Neutral MSH2 P43246 Q158W 158 Q W 0.884 Pathogenic MSH2 P43246 Q158Y 158 Q Y 0.834 Pathogenic MSH2 P43246 R159A 159 R A 0.044 Neutral MSH2 P43246 R159C 159 R C 0.25 Neutral MSH2 P43246 R159D 159 R D 0.026 Neutral MSH2 P43246 R159E 159 R E 0.032 Neutral MSH2 P43246 R159F 159 R F 0.444 Neutral MSH2 P43246 R159G 159 R G 0.006 Neutral MSH2 P43246 R159H 159 R H 0.192 Neutral MSH2 P43246 R159I 159 R I 0.164 Neutral MSH2 P43246 R159K 159 R K 0.01 Neutral MSH2 P43246 R159L 159 R L 0.124 Neutral MSH2 P43246 R159M 159 R M 0.254 Neutral MSH2 P43246 R159N 159 R N 0.092 Neutral MSH2 P43246 R159P 159 R P 0.424 Neutral MSH2 P43246 R159Q 159 R Q 0.014 Neutral MSH2 P43246 R159S 159 R S 0.022 Neutral MSH2 P43246 R159T 159 R T 0.236 Neutral MSH2 P43246 R159V 159 R V 0.044 Neutral MSH2 P43246 R159W 159 R W 0.632 Pathogenic MSH2 P43246 R159Y 159 R Y 0.46 Neutral MSH2 P43246 E16A 16 E A 0.214 Neutral MSH2 P43246 E16C 16 E C 0.45 Neutral MSH2 P43246 E16D 16 E D 0.024 Neutral MSH2 P43246 E16F 16 E F 0.848 Pathogenic MSH2 P43246 E16G 16 E G 0.202 Neutral MSH2 P43246 E16H 16 E H 0.068 Neutral MSH2 P43246 E16I 16 E I 0.91 Pathogenic MSH2 P43246 E16K 16 E K 0.708 Pathogenic MSH2 P43246 E16L 16 E L 0.886 Pathogenic MSH2 P43246 E16M 16 E M 0.69 Pathogenic MSH2 P43246 E16N 16 E N 0.112 Neutral MSH2 P43246 E16P 16 E P 0.872 Pathogenic MSH2 P43246 E16Q 16 E Q 0.014 Neutral MSH2 P43246 E16R 16 E R 0.134 Neutral MSH2 P43246 E16S 16 E S 0.2 Neutral MSH2 P43246 E16T 16 E T 0.556 Pathogenic MSH2 P43246 E16V 16 E V 0.828 Pathogenic MSH2 P43246 E16W 16 E W 0.968 Pathogenic MSH2 P43246 E16Y 16 E Y 0.91 Pathogenic MSH2 P43246 Q160A 160 Q A 0.076 Neutral MSH2 P43246 Q160C 160 Q C 0 Neutral MSH2 P43246 Q160D 160 Q D 0.046 Neutral MSH2 P43246 Q160E 160 Q E 0.068 Neutral MSH2 P43246 Q160F 160 Q F 0.26 Neutral MSH2 P43246 Q160G 160 Q G 0.03 Neutral MSH2 P43246 Q160H 160 Q H 0.14 Neutral MSH2 P43246 Q160I 160 Q I 0.246 Neutral MSH2 P43246 Q160K 160 Q K 0.02 Neutral MSH2 P43246 Q160L 160 Q L 0.116 Neutral MSH2 P43246 Q160M 160 Q M 0.186 Neutral MSH2 P43246 Q160N 160 Q N 0.026 Neutral MSH2 P43246 Q160P 160 Q P 0.294 Neutral MSH2 P43246 Q160R 160 Q R 0.002 Neutral MSH2 P43246 Q160S 160 Q S 0.112 Neutral MSH2 P43246 Q160T 160 Q T 0.014 Neutral MSH2 P43246 Q160V 160 Q V 0.01 Neutral MSH2 P43246 Q160W 160 Q W 0.42 Neutral MSH2 P43246 Q160Y 160 Q Y 0.362 Neutral MSH2 P43246 V161A 161 V A 0.052 Neutral MSH2 P43246 V161C 161 V C 0.11 Neutral MSH2 P43246 V161D 161 V D 0.204 Neutral MSH2 P43246 V161E 161 V E 0.334 Neutral MSH2 P43246 V161F 161 V F 0.366 Neutral MSH2 P43246 V161G 161 V G 0.282 Neutral MSH2 P43246 V161H 161 V H 0.232 Neutral MSH2 P43246 V161I 161 V I 0.024 Neutral MSH2 P43246 V161K 161 V K 0.286 Neutral MSH2 P43246 V161L 161 V L 0.066 Neutral MSH2 P43246 V161M 161 V M 0.176 Neutral MSH2 P43246 V161N 161 V N 0.222 Neutral MSH2 P43246 V161P 161 V P 0.34 Neutral MSH2 P43246 V161Q 161 V Q 0.358 Neutral MSH2 P43246 V161R 161 V R 0.492 Neutral MSH2 P43246 V161S 161 V S 0.148 Neutral MSH2 P43246 V161T 161 V T 0.074 Neutral MSH2 P43246 V161W 161 V W 0.44 Neutral MSH2 P43246 V161Y 161 V Y 0.458 Neutral MSH2 P43246 G162A 162 G A 0.102 Neutral MSH2 P43246 G162C 162 G C 0.374 Neutral MSH2 P43246 G162D 162 G D 0.438 Neutral MSH2 P43246 G162E 162 G E 0.578 Pathogenic MSH2 P43246 G162F 162 G F 0.776 Pathogenic MSH2 P43246 G162H 162 G H 0.72 Pathogenic MSH2 P43246 G162I 162 G I 0.692 Pathogenic MSH2 P43246 G162K 162 G K 0.702 Pathogenic MSH2 P43246 G162L 162 G L 0.692 Pathogenic MSH2 P43246 G162M 162 G M 0.71 Pathogenic MSH2 P43246 G162N 162 G N 0.43 Neutral MSH2 P43246 G162P 162 G P 0.696 Pathogenic MSH2 P43246 G162Q 162 G Q 0.464 Neutral MSH2 P43246 G162R 162 G R 0.768 Pathogenic 5 MSH2 P43246 G162S 162 G S 0.034 Neutral MSH2 P43246 G162T 162 G T 0.49 Neutral MSH2 P43246 G162V 162 G V 0.672 Pathogenic MSH2 P43246 G162W 162 G W 0.774 Pathogenic MSH2 P43246 G162Y 162 G Y 0.738 Pathogenic MSH2 P43246 V163A 163 V A 0.068 Neutral MSH2 P43246 V163C 163 V C 0.14 Neutral MSH2 P43246 V163D 163 V D 0.85 Pathogenic 5 MSH2 P43246 V163E 163 V E 0.962 Pathogenic MSH2 P43246 V163F 163 V F 0.628 Pathogenic MSH2 P43246 V163G 163 V G 0.898 Pathogenic 5 MSH2 P43246 V163H 163 V H 0.78 Pathogenic MSH2 P43246 V163I 163 V I 0.154 Neutral MSH2 P43246 V163K 163 V K 0.942 Pathogenic MSH2 P43246 V163L 163 V L 0.186 Neutral MSH2 P43246 V163M 163 V M 0.278 Neutral MSH2 P43246 V163N 163 V N 0.92 Pathogenic MSH2 P43246 V163P 163 V P 0.944 Pathogenic MSH2 P43246 V163Q 163 V Q 0.976 Pathogenic MSH2 P43246 V163R 163 V R 0.95 Pathogenic MSH2 P43246 V163S 163 V S 0.212 Neutral MSH2 P43246 V163T 163 V T 0.156 Neutral MSH2 P43246 V163W 163 V W 0.892 Pathogenic MSH2 P43246 V163Y 163 V Y 0.676 Pathogenic MSH2 P43246 G164A 164 G A 0.268 Neutral MSH2 P43246 G164C 164 G C 0.592 Pathogenic MSH2 P43246 G164D 164 G D 0.92 Pathogenic MSH2 P43246 G164E 164 G E 0.958 Pathogenic MSH2 P43246 G164F 164 G F 0.948 Pathogenic MSH2 P43246 G164H 164 G H 0.944 Pathogenic MSH2 P43246 G164I 164 G I 0.94 Pathogenic MSH2 P43246 G164K 164 G K 0.952 Pathogenic MSH2 P43246 G164L 164 G L 0.95 Pathogenic MSH2 P43246 G164M 164 G M 0.964 Pathogenic MSH2 P43246 G164N 164 G N 0.88 Pathogenic MSH2 P43246 G164P 164 G P 0.91 Pathogenic MSH2 P43246 G164Q 164 G Q 0.932 Pathogenic MSH2 P43246 G164R 164 G R 0.984 Pathogenic 5 MSH2 P43246 G164S 164 G S 0.26 Neutral MSH2 P43246 G164T 164 G T 0.65 Pathogenic MSH2 P43246 G164V 164 G V 0.902 Pathogenic MSH2 P43246 G164W 164 G W 0.928 Pathogenic MSH2 P43246 G164Y 164 G Y 0.916 Pathogenic MSH2 P43246 Y165A 165 Y A 0.144 Neutral MSH2 P43246 Y165C 165 Y C 0.16 Neutral MSH2 P43246 Y165D 165 Y D 0.788 Pathogenic 4 MSH2 P43246 Y165E 165 Y E 0.706 Pathogenic MSH2 P43246 Y165F 165 Y F 0.064 Neutral MSH2 P43246 Y165G 165 Y G 0.378 Neutral MSH2 P43246 Y165H 165 Y H 0.46 Neutral MSH2 P43246 Y165I 165 Y I 0.258 Neutral MSH2 P43246 Y165K 165 Y K 0.802 Pathogenic MSH2 P43246 Y165L 165 Y L 0.19 Neutral MSH2 P43246 Y165M 165 Y M 0.58 Pathogenic MSH2 P43246 Y165N 165 Y N 0.612 Pathogenic MSH2 P43246 Y165P 165 Y P 0.7 Pathogenic MSH2 P43246 Y165Q 165 Y Q 0.524 Pathogenic MSH2 P43246 Y165R 165 Y R 0.738 Pathogenic MSH2 P43246 Y165S 165 Y S 0.162 Neutral MSH2 P43246 Y165T 165 Y T 0.532 Pathogenic MSH2 P43246 Y165V 165 Y V 0.74 Pathogenic MSH2 P43246 Y165W 165 Y W 0.79 Pathogenic MSH2 P43246 V166A 166 V A 0.134 Neutral MSH2 P43246 V166C 166 V C 0.138 Neutral MSH2 P43246 V166D 166 V D 0.868 Pathogenic MSH2 P43246 V166E 166 V E 0.982 Pathogenic MSH2 P43246 V166F 166 V F 0.872 Pathogenic MSH2 P43246 V166G 166 V G 0.19 Neutral MSH2 P43246 V166H 166 V H 0.814 Pathogenic MSH2 P43246 V166I 166 V I 0.176 Neutral MSH2 P43246 V166K 166 V K 0.974 Pathogenic MSH2 P43246 V166L 166 V L 0.246 Neutral MSH2 P43246 V166M 166 V M 0.812 Pathogenic MSH2 P43246 V166N 166 V N 0.934 Pathogenic MSH2 P43246 V166P 166 V P 0.976 Pathogenic MSH2 P43246 V166Q 166 V Q 0.992 Pathogenic MSH2 P43246 V166R 166 V R 0.96 Pathogenic MSH2 P43246 V166S 166 V S 0.372 Neutral MSH2 P43246 V166T 166 V T 0.164 Neutral MSH2 P43246 V166W 166 V W 0.902 Pathogenic MSH2 P43246 V166Y 166 V Y 0.928 Pathogenic MSH2 P43246 D167A 167 D A 0.768 Pathogenic MSH2 P43246 D167C 167 D C 0.846 Pathogenic MSH2 P43246 D167E 167 D E 0.23 Neutral MSH2 P43246 D167F 167 D F 0.966 Pathogenic MSH2 P43246 D167G 167 D G 0.914 Pathogenic MSH2 P43246 D167H 167 D H 0.576 Pathogenic MSH2 P43246 D167I 167 D I 0.958 Pathogenic MSH2 P43246 D167K 167 D K 0.868 Pathogenic MSH2 P43246 D167L 167 D L 0.958 Pathogenic MSH2 P43246 D167M 167 D M 0.936 Pathogenic MSH2 P43246 D167N 167 D N 0.23 Neutral MSH2 P43246 D167P 167 D P 0.872 Pathogenic MSH2 P43246 D167Q 167 D Q 0.536 Pathogenic MSH2 P43246 D167R 167 D R 0.944 Pathogenic MSH2 P43246 D167S 167 D S 0.504 Pathogenic MSH2 P43246 D167T 167 D T 0.75 Pathogenic MSH2 P43246 D167V 167 D V 0.762 Pathogenic MSH2 P43246 D167W 167 D W 0.972 Pathogenic MSH2 P43246 D167Y 167 D Y 0.962 Pathogenic MSH2 P43246 S168A 168 S A 0.12 Neutral MSH2 P43246 S168C 168 S C 0.504 Pathogenic MSH2 P43246 S168D 168 S D 0.544 Pathogenic MSH2 P43246 S168E 168 S E 0.758 Pathogenic MSH2 P43246 S168F 168 S F 0.798 Pathogenic MSH2 P43246 S168G 168 S G 0.198 Neutral MSH2 P43246 S168H 168 S H 0.818 Pathogenic MSH2 P43246 S168I 168 S I 0.466 Neutral MSH2 P43246 S168K 168 S K 0.626 Pathogenic MSH2 P43246 S168L 168 S L 0.152 Neutral MSH2 P43246 S168M 168 S M 0.582 Pathogenic MSH2 P43246 S168N 168 S N 0.108 Neutral MSH2 P43246 S168P 168 S P 0.66 Pathogenic MSH2 P43246 S168Q 168 S Q 0.484 Neutral MSH2 P43246 S168R 168 S R 0.826 Pathogenic MSH2 P43246 S168T 168 S T 0.052 Neutral MSH2 P43246 S168V 168 S V 0.09 Neutral MSH2 P43246 S168W 168 S W 0.954 Pathogenic MSH2 P43246 S168Y 168 S Y 0.936 Pathogenic MSH2 P43246 I169A 169 I A 0.048 Neutral MSH2 P43246 I169C 169 I C 0.41 Neutral MSH2 P43246 I169D 169 I D 0.612 Pathogenic MSH2 P43246 I169E 169 I E 0.594 Pathogenic MSH2 P43246 I169F 169 I F 0.708 Pathogenic MSH2 P43246 I169G 169 I G 0.588 Pathogenic MSH2 P43246 I169H 169 I H 0.474 Neutral MSH2 P43246 I169K 169 I K 0.608 Pathogenic MSH2 P43246 I169L 169 I L 0.018 Neutral MSH2 P43246 I169M 169 I M 0.078 Neutral MSH2 P43246 I169N 169 I N 0.152 Neutral MSH2 P43246 I169P 169 I P 0.756 Pathogenic MSH2 P43246 I169Q 169 I Q 0.276 Neutral MSH2 P43246 I169R 169 I R 0.546 Pathogenic MSH2 P43246 I169S 169 I S 0.142 Neutral MSH2 P43246 I169T 169 I T 0.022 Neutral MSH2 P43246 I169V 169 I V 0.016 Neutral 2 MSH2 P43246 I169W 169 I W 0.904 Pathogenic MSH2 P43246 I169Y 169 I Y 0.85 Pathogenic MSH2 P43246 V17A 17 V A 0 Neutral MSH2 P43246 V17C 17 V C 0.058 Neutral MSH2 P43246 V17D 17 V D 0.032 Neutral MSH2 P43246 V17E 17 V E 0.19 Neutral MSH2 P43246 V17F 17 V F 0.168 Neutral MSH2 P43246 V17G 17 V G 0.04 Neutral MSH2 P43246 V17H 17 V H 0.054 Neutral MSH2 P43246 V17I 17 V I 0.002 Neutral MSH2 P43246 V17K 17 V K 0.084 Neutral MSH2 P43246 V17L 17 V L 0 Neutral MSH2 P43246 V17M 17 V M 0.088 Neutral MSH2 P43246 V17N 17 V N 0.044 Neutral MSH2 P43246 V17P 17 V P 0.042 Neutral MSH2 P43246 V17Q 17 V Q 0.056 Neutral MSH2 P43246 V17R 17 V R 0.258 Neutral MSH2 P43246 V17S 17 V S 0.012 Neutral MSH2 P43246 V17T 17 V T 0.008 Neutral MSH2 P43246 V17W 17 V W 0.386 Neutral MSH2 P43246 V17Y 17 V Y 0.186 Neutral MSH2 P43246 Q170A 170 Q A 0.056 Neutral MSH2 P43246 Q170C 170 Q C 0.128 Neutral MSH2 P43246 Q170D 170 Q D 0 Neutral MSH2 P43246 Q170E 170 Q E 0.008 Neutral MSH2 P43246 Q170F 170 Q F 0.374 Neutral MSH2 P43246 Q170G 170 Q G 0.092 Neutral MSH2 P43246 Q170H 170 Q H 0.364 Neutral MSH2 P43246 Q170I 170 Q I 0.262 Neutral MSH2 P43246 Q170K 170 Q K 0.026 Neutral MSH2 P43246 Q170L 170 Q L 0.132 Neutral MSH2 P43246 Q170M 170 Q M 0.028 Neutral MSH2 P43246 Q170N 170 Q N 0.024 Neutral MSH2 P43246 Q170P 170 Q P 0.492 Neutral MSH2 P43246 Q170R 170 Q R 0.012 Neutral MSH2 P43246 Q170S 170 Q S 0.05 Neutral MSH2 P43246 Q170T 170 Q T 0.004 Neutral MSH2 P43246 Q170V 170 Q V 0.04 Neutral MSH2 P43246 Q170W 170 Q W 0.724 Pathogenic MSH2 P43246 Q170Y 170 Q Y 0.632 Pathogenic MSH2 P43246 R171A 171 R A 0.262 Neutral MSH2 P43246 R171C 171 R C 0.2 Neutral MSH2 P43246 R171D 171 R D 0.872 Pathogenic MSH2 P43246 R171E 171 R E 0.368 Neutral MSH2 P43246 R171F 171 R F 0.76 Pathogenic MSH2 P43246 R171G 171 R G 0.414 Neutral MSH2 P43246 R171H 171 R H 0.186 Neutral MSH2 P43246 R171I 171 R I 0.974 Pathogenic MSH2 P43246 R171K 171 R K 0.352 Neutral MSH2 P43246 R171L 171 R L 0.676 Pathogenic MSH2 P43246 R171M 171 R M 0.8 Pathogenic MSH2 P43246 R171N 171 R N 0.36 Neutral MSH2 P43246 R171P 171 R P 0.984 Pathogenic MSH2 P43246 R171Q 171 R Q 0.116 Neutral MSH2 P43246 R171S 171 R S 0.206 Neutral MSH2 P43246 R171T 171 R T 0.186 Neutral MSH2 P43246 R171V 171 R V 0.972 Pathogenic MSH2 P43246 R171W 171 R W 0.892 Pathogenic MSH2 P43246 R171Y 171 R Y 0.368 Neutral MSH2 P43246 K172A 172 K A 0.238 Neutral MSH2 P43246 K172C 172 K C 0.192 Neutral MSH2 P43246 K172D 172 K D 0.146 Neutral MSH2 P43246 K172E 172 K E 0.07 Neutral MSH2 P43246 K172F 172 K F 0.844 Pathogenic MSH2 P43246 K172G 172 K G 0.354 Neutral MSH2 P43246 K172H 172 K H 0.386 Neutral MSH2 P43246 K172I 172 K I 0.132 Neutral MSH2 P43246 K172L 172 K L 0.118 Neutral MSH2 P43246 K172M 172 K M 0.272 Neutral MSH2 P43246 K172N 172 K N 0.156 Neutral MSH2 P43246 K172P 172 K P 0.828 Pathogenic MSH2 P43246 K172Q 172 K Q 0.028 Neutral MSH2 P43246 K172R 172 K R 0.034 Neutral MSH2 P43246 K172S 172 K S 0.032 Neutral MSH2 P43246 K172T 172 K T 0.038 Neutral MSH2 P43246 K172V 172 K V 0.102 Neutral MSH2 P43246 K172W 172 K W 0.978 Pathogenic MSH2 P43246 K172Y 172 K Y 0.932 Pathogenic MSH2 P43246 L173A 173 L A 0.56 Pathogenic MSH2 P43246 L173C 173 L C 0.678 Pathogenic MSH2 P43246 L173D 173 L D 0.898 Pathogenic MSH2 P43246 L173E 173 L E 0.878 Pathogenic MSH2 P43246 L173F 173 L F 0.444 Neutral MSH2 P43246 L173G 173 L G 0.802 Pathogenic MSH2 P43246 L173H 173 L H 0.796 Pathogenic MSH2 P43246 L173I 173 L I 0.126 Neutral MSH2 P43246 L173K 173 L K 0.746 Pathogenic MSH2 P43246 L173M 173 L M 0.164 Neutral MSH2 P43246 L173N 173 L N 0.768 Pathogenic MSH2 P43246 L173P 173 L P 0.998 Pathogenic MSH2 P43246 L173Q 173 L Q 0.612 Pathogenic MSH2 P43246 L173R 173 L R 0.992 Pathogenic MSH2 P43246 L173S 173 L S 0.612 Pathogenic MSH2 P43246 L173T 173 L T 0.588 Pathogenic MSH2 P43246 L173V 173 L V 0.096 Neutral MSH2 P43246 L173W 173 L W 0.94 Pathogenic MSH2 P43246 L173Y 173 L Y 0.902 Pathogenic MSH2 P43246 G174A 174 G A 0.348 Neutral MSH2 P43246 G174C 174 G C 0.594 Pathogenic MSH2 P43246 G174D 174 G D 0.958 Pathogenic MSH2 P43246 G174E 174 G E 0.678 Pathogenic MSH2 P43246 G174F 174 G F 0.988 Pathogenic MSH2 P43246 G174H 174 G H 0.722 Pathogenic MSH2 P43246 G174I 174 G I 0.978 Pathogenic MSH2 P43246 G174K 174 G K 0.896 Pathogenic MSH2 P43246 G174L 174 G L 0.726 Pathogenic MSH2 P43246 G174M 174 G M 0.69 Pathogenic MSH2 P43246 G174N 174 G N 0.514 Pathogenic MSH2 P43246 G174P 174 G P 0.982 Pathogenic MSH2 P43246 G174Q 174 G Q 0.576 Pathogenic MSH2 P43246 G174R 174 G R 0.742 Pathogenic MSH2 P43246 G174S 174 G S 0.31 Neutral MSH2 P43246 G174T 174 G T 0.822 Pathogenic MSH2 P43246 G174V 174 G V 0.914 Pathogenic MSH2 P43246 G174W 174 G W 0.984 Pathogenic MSH2 P43246 G174Y 174 G Y 0.988 Pathogenic MSH2 P43246 L175A 175 L A 0.108 Neutral MSH2 P43246 L175C 175 L C 0.678 Pathogenic MSH2 P43246 L175D 175 L D 0.898 Pathogenic MSH2 P43246 L175E 175 L E 0.878 Pathogenic MSH2 P43246 L175F 175 L F 0.976 Pathogenic MSH2 P43246 L175G 175 L G 0.802 Pathogenic MSH2 P43246 L175H 175 L H 0.796 Pathogenic MSH2 P43246 L175I 175 L I 0.168 Neutral MSH2 P43246 L175K 175 L K 0.746 Pathogenic MSH2 P43246 L175M 175 L M 0.174 Neutral MSH2 P43246 L175N 175 L N 0.768 Pathogenic MSH2 P43246 L175P 175 L P 0.998 Pathogenic MSH2 P43246 L175Q 175 L Q 0.612 Pathogenic MSH2 P43246 L175R 175 L R 0.992 Pathogenic MSH2 P43246 L175S 175 L S 0.612 Pathogenic MSH2 P43246 L175T 175 L T 0.332 Neutral MSH2 P43246 L175V 175 L V 0.2 Neutral MSH2 P43246 L175W 175 L W 0.94 Pathogenic MSH2 P43246 L175Y 175 L Y 0.652 Pathogenic MSH2 P43246 C176A 176 C A 0.044 Neutral MSH2 P43246 C176D 176 C D 0.598 Pathogenic MSH2 P43246 C176E 176 C E 0.618 Pathogenic MSH2 P43246 C176F 176 C F 0.904 Pathogenic MSH2 P43246 C176G 176 C G 0.136 Neutral MSH2 P43246 C176H 176 C H 0.746 Pathogenic MSH2 P43246 C176I 176 C I 0.262 Neutral MSH2 P43246 C176K 176 C K 0.674 Pathogenic MSH2 P43246 C176L 176 C L 0.078 Neutral MSH2 P43246 C176M 176 C M 0.574 Pathogenic MSH2 P43246 C176N 176 C N 0.364 Neutral MSH2 P43246 C176P 176 C P 0.89 Pathogenic MSH2 P43246 C176Q 176 C Q 0.518 Pathogenic MSH2 P43246 C176R 176 C R 0.914 Pathogenic MSH2 P43246 C176S 176 C S 0.068 Neutral MSH2 P43246 C176T 176 C T 0.012 Neutral MSH2 P43246 C176V 176 C V 0.092 Neutral MSH2 P43246 C176W 176 C W 0.948 Pathogenic MSH2 P43246 C176Y 176 C Y 0.952 Pathogenic MSH2 P43246 E177A 177 E A 0.446 Neutral MSH2 P43246 E177C 177 E C 0.75 Pathogenic MSH2 P43246 E177D 177 E D 0.182 Neutral MSH2 P43246 E177F 177 E F 0.966 Pathogenic MSH2 P43246 E177G 177 E G 0.382 Neutral MSH2 P43246 E177H 177 E H 0.844 Pathogenic MSH2 P43246 E177I 177 E I 0.98 Pathogenic MSH2 P43246 E177K 177 E K 0.97 Pathogenic MSH2 P43246 E177L 177 E L 0.972 Pathogenic MSH2 P43246 E177M 177 E M 0.914 Pathogenic MSH2 P43246 E177N 177 E N 0.312 Neutral MSH2 P43246 E177P 177 E P 0.932 Pathogenic MSH2 P43246 E177Q 177 E Q 0.164 Neutral MSH2 P43246 E177R 177 E R 0.924 Pathogenic MSH2 P43246 E177S 177 E S 0.89 Pathogenic MSH2 P43246 E177T 177 E T 0.346 Neutral MSH2 P43246 E177V 177 E V 0.914 Pathogenic MSH2 P43246 E177W 177 E W 0.984 Pathogenic MSH2 P43246 E177Y 177 E Y 0.964 Pathogenic MSH2 P43246 F178A 178 F A 0.5 Pathogenic MSH2 P43246 F178C 178 F C 0.73 Pathogenic MSH2 P43246 F178D 178 F D 0.814 Pathogenic MSH2 P43246 F178E 178 F E 0.858 Pathogenic MSH2 P43246 F178G 178 F G 0.512 Pathogenic MSH2 P43246 F178H 178 F H 0.76 Pathogenic MSH2 P43246 F178I 178 F I 0.234 Neutral MSH2 P43246 F178K 178 F K 0.836 Pathogenic MSH2 P43246 F178L 178 F L 0.286 Neutral MSH2 P43246 F178M 178 F M 0.778 Pathogenic MSH2 P43246 F178N 178 F N 0.762 Pathogenic MSH2 P43246 F178P 178 F P 0.952 Pathogenic MSH2 P43246 F178Q 178 F Q 0.774 Pathogenic MSH2 P43246 F178R 178 F R 0.906 Pathogenic MSH2 P43246 F178S 178 F S 0.884 Pathogenic MSH2 P43246 F178T 178 F T 0.592 Pathogenic MSH2 P43246 F178V 178 F V 0.728 Pathogenic MSH2 P43246 F178W 178 F W 0.85 Pathogenic MSH2 P43246 F178Y 178 F Y 0.276 Neutral MSH2 P43246 P179A 179 P A 0.07 Neutral MSH2 P43246 P179C 179 P C 0.494 Neutral MSH2 P43246 P179D 179 P D 0.136 Neutral MSH2 P43246 P179E 179 P E 0.308 Neutral MSH2 P43246 P179F 179 P F 0.976 Pathogenic MSH2 P43246 P179G 179 P G 0.27 Neutral MSH2 P43246 P179H 179 P H 0.856 Pathogenic MSH2 P43246 P179I 179 P I 0.144 Neutral MSH2 P43246 P179K 179 P K 0.544 Pathogenic MSH2 P43246 P179L 179 P L 0.11 Neutral MSH2 P43246 P179M 179 P M 0.258 Neutral MSH2 P43246 P179N 179 P N 0.31 Neutral MSH2 P43246 P179Q 179 P Q 0.146 Neutral MSH2 P43246 P179R 179 P R 0.87 Pathogenic MSH2 P43246 P179S 179 P S 0.04 Neutral MSH2 P43246 P179T 179 P T 0.046 Neutral MSH2 P43246 P179V 179 P V 0.066 Neutral MSH2 P43246 P179W 179 P W 0.926 Pathogenic MSH2 P43246 P179Y 179 P Y 0.91 Pathogenic MSH2 P43246 G18A 18 G A 0.116 Neutral MSH2 P43246 G18C 18 G C 0.798 Pathogenic MSH2 P43246 G18D 18 G D 0.656 Pathogenic MSH2 P43246 G18E 18 G E 0.924 Pathogenic MSH2 P43246 G18F 18 G F 0.944 Pathogenic MSH2 P43246 G18H 18 G H 0.934 Pathogenic MSH2 P43246 G18I 18 G I 0.926 Pathogenic MSH2 P43246 G18K 18 G K 0.728 Pathogenic MSH2 P43246 G18L 18 G L 0.904 Pathogenic MSH2 P43246 G18M 18 G M 0.95 Pathogenic MSH2 P43246 G18N 18 G N 0.508 Pathogenic MSH2 P43246 G18P 18 G P 0.894 Pathogenic MSH2 P43246 G18Q 18 G Q 0.708 Pathogenic MSH2 P43246 G18R 18 G R 0.646 Pathogenic MSH2 P43246 G18S 18 G S 0.098 Neutral MSH2 P43246 G18T 18 G T 0.658 Pathogenic MSH2 P43246 G18V 18 G V 0.936 Pathogenic MSH2 P43246 G18W 18 G W 0.93 Pathogenic MSH2 P43246 G18Y 18 G Y 0.892 Pathogenic MSH2 P43246 D180A 180 D A 0.78 Pathogenic MSH2 P43246 D180C 180 D C 0.862 Pathogenic MSH2 P43246 D180E 180 D E 0.218 Neutral MSH2 P43246 D180F 180 D F 0.974 Pathogenic MSH2 P43246 D180G 180 D G 0.934 Pathogenic MSH2 P43246 D180H 180 D H 0.596 Pathogenic MSH2 P43246 D180I 180 D I 0.964 Pathogenic MSH2 P43246 D180K 180 D K 0.888 Pathogenic MSH2 P43246 D180L 180 D L 0.966 Pathogenic MSH2 P43246 D180M 180 D M 0.944 Pathogenic MSH2 P43246 D180N 180 D N 0.844 Pathogenic MSH2 P43246 D180P 180 D P 0.884 Pathogenic MSH2 P43246 D180Q 180 D Q 0.574 Pathogenic MSH2 P43246 D180R 180 D R 0.954 Pathogenic MSH2 P43246 D180S 180 D S 0.542 Pathogenic MSH2 P43246 D180T 180 D T 0.772 Pathogenic MSH2 P43246 D180V 180 D V 0.768 Pathogenic MSH2 P43246 D180W 180 D W 0.976 Pathogenic MSH2 P43246 D180Y 180 D Y 0.892 Pathogenic MSH2 P43246 N181A 181 N A 0.756 Pathogenic MSH2 P43246 N181C 181 N C 0.802 Pathogenic MSH2 P43246 N181D 181 N D 0.196 Neutral MSH2 P43246 N181E 181 N E 0.74 Pathogenic MSH2 P43246 N181F 181 N F 0.966 Pathogenic MSH2 P43246 N181G 181 N G 0.402 Neutral MSH2 P43246 N181H 181 N H 0.948 Pathogenic MSH2 P43246 N181I 181 N I 0.95 Pathogenic MSH2 P43246 N181K 181 N K 0.604 Pathogenic MSH2 P43246 N181L 181 N L 0.968 Pathogenic MSH2 P43246 N181M 181 N M 0.974 Pathogenic MSH2 P43246 N181P 181 N P 0.896 Pathogenic MSH2 P43246 N181Q 181 N Q 0.41 Neutral MSH2 P43246 N181R 181 N R 0.93 Pathogenic MSH2 P43246 N181S 181 N S 0.208 Neutral MSH2 P43246 N181T 181 N T 0.258 Neutral MSH2 P43246 N181V 181 N V 0.99 Pathogenic MSH2 P43246 N181W 181 N W 0.978 Pathogenic MSH2 P43246 N181Y 181 N Y 0.942 Pathogenic MSH2 P43246 D182A 182 D A 0.342 Neutral MSH2 P43246 D182C 182 D C 0.92 Pathogenic MSH2 P43246 D182E 182 D E 0.216 Neutral MSH2 P43246 D182F 182 D F 0.984 Pathogenic MSH2 P43246 D182G 182 D G 0.922 Pathogenic MSH2 P43246 D182H 182 D H 0.654 Pathogenic MSH2 P43246 D182I 182 D I 0.808 Pathogenic MSH2 P43246 D182K 182 D K 0.986 Pathogenic MSH2 P43246 D182L 182 D L 0.98 Pathogenic MSH2 P43246 D182M 182 D M 0.962 Pathogenic MSH2 P43246 D182N 182 D N 0.282 Neutral MSH2 P43246 D182P 182 D P 0.912 Pathogenic MSH2 P43246 D182Q 182 D Q 0.438 Neutral MSH2 P43246 D182R 182 D R 0.92 Pathogenic MSH2 P43246 D182S 182 D S 0.1 Neutral MSH2 P43246 D182T 182 D T 0.456 Neutral MSH2 P43246 D182V 182 D V 0.992 Pathogenic MSH2 P43246 D182W 182 D W 0.986 Pathogenic MSH2 P43246 D182Y 182 D Y 0.98 Pathogenic MSH2 P43246 Q183A 183 Q A 0.284 Neutral MSH2 P43246 Q183C 183 Q C 0.38 Neutral MSH2 P43246 Q183D 183 Q D 0.456 Neutral MSH2 P43246 Q183E 183 Q E 0.53 Pathogenic MSH2 P43246 Q183F 183 Q F 0.328 Neutral MSH2 P43246 Q183G 183 Q G 0.22 Neutral MSH2 P43246 Q183H 183 Q H 0.082 Neutral MSH2 P43246 Q183I 183 Q I 0.33 Neutral MSH2 P43246 Q183K 183 Q K 0.414 Neutral MSH2 P43246 Q183L 183 Q L 0.202 Neutral MSH2 P43246 Q183M 183 Q M 0.684 Pathogenic MSH2 P43246 Q183N 183 Q N 0.128 Neutral MSH2 P43246 Q183P 183 Q P 0.842 Pathogenic MSH2 P43246 Q183R 183 Q R 0.098 Neutral MSH2 P43246 Q183S 183 Q S 0.102 Neutral MSH2 P43246 Q183T 183 Q T 0.146 Neutral MSH2 P43246 Q183V 183 Q V 0.108 Neutral MSH2 P43246 Q183W 183 Q W 0.9 Pathogenic MSH2 P43246 Q183Y 183 Q Y 0.672 Pathogenic MSH2 P43246 F184A 184 F A 0.458 Neutral MSH2 P43246 F184C 184 F C 0.634 Pathogenic MSH2 P43246 F184D 184 F D 0.75 Pathogenic MSH2 P43246 F184E 184 F E 0.816 Pathogenic MSH2 P43246 F184G 184 F G 0.464 Neutral MSH2 P43246 F184H 184 F H 0.32 Neutral MSH2 P43246 F184I 184 F I 0.602 Pathogenic MSH2 P43246 F184K 184 F K 0.8 Pathogenic MSH2 P43246 F184L 184 F L 0.112 Neutral MSH2 P43246 F184M 184 F M 0.31 Neutral MSH2 P43246 F184N 184 F N 0.666 Pathogenic MSH2 P43246 F184P 184 F P 0.93 Pathogenic MSH2 P43246 F184Q 184 F Q 0.69 Pathogenic MSH2 P43246 F184R 184 F R 0.88 Pathogenic MSH2 P43246 F184S 184 F S 0.76 Pathogenic MSH2 P43246 F184T 184 F T 0.552 Pathogenic MSH2 P43246 F184V 184 F V 0.82 Pathogenic MSH2 P43246 F184W 184 F W 0.692 Pathogenic MSH2 P43246 F184Y 184 F Y 0.26 Neutral MSH2 P43246 S185A 185 S A 0.246 Neutral MSH2 P43246 S185C 185 S C 0.33 Neutral MSH2 P43246 S185D 185 S D 0.876 Pathogenic MSH2 P43246 S185E 185 S E 0.942 Pathogenic MSH2 P43246 S185F 185 S F 0.982 Pathogenic MSH2 P43246 S185G 185 S G 0.13 Neutral MSH2 P43246 S185H 185 S H 0.958 Pathogenic MSH2 P43246 S185I 185 S I 0.796 Pathogenic MSH2 P43246 S185K 185 S K 0.936 Pathogenic MSH2 P43246 S185L 185 S L 0.922 Pathogenic MSH2 P43246 S185M 185 S M 0.88 Pathogenic MSH2 P43246 S185N 185 S N 0.436 Neutral MSH2 P43246 S185P 185 S P 0.958 Pathogenic MSH2 P43246 S185Q 185 S Q 0.922 Pathogenic MSH2 P43246 S185R 185 S R 0.96 Pathogenic MSH2 P43246 S185T 185 S T 0.284 Neutral MSH2 P43246 S185V 185 S V 0.97 Pathogenic MSH2 P43246 S185W 185 S W 0.982 Pathogenic MSH2 P43246 S185Y 185 S Y 0.98 Pathogenic MSH2 P43246 N186A 186 N A 0.464 Neutral MSH2 P43246 N186C 186 N C 0.73 Pathogenic MSH2 P43246 N186D 186 N D 0.238 Neutral MSH2 P43246 N186E 186 N E 0.224 Neutral MSH2 P43246 N186F 186 N F 0.95 Pathogenic MSH2 P43246 N186G 186 N G 0.672 Pathogenic MSH2 P43246 N186H 186 N H 0.828 Pathogenic MSH2 P43246 N186I 186 N I 0.936 Pathogenic MSH2 P43246 N186K 186 N K 0.884 Pathogenic MSH2 P43246 N186L 186 N L 0.942 Pathogenic MSH2 P43246 N186M 186 N M 0.944 Pathogenic MSH2 P43246 N186P 186 N P 0.834 Pathogenic MSH2 P43246 N186Q 186 N Q 0.446 Neutral MSH2 P43246 N186R 186 N R 0.948 Pathogenic MSH2 P43246 N186S 186 N S 0.194 Neutral MSH2 P43246 N186T 186 N T 0.192 Neutral MSH2 P43246 N186V 186 N V 0.746 Pathogenic MSH2 P43246 N186W 186 N W 0.966 Pathogenic MSH2 P43246 N186Y 186 N Y 0.896 Pathogenic MSH2 P43246 L187A 187 L A 0.57 Pathogenic MSH2 P43246 L187C 187 L C 0.694 Pathogenic MSH2 P43246 L187D 187 L D 0.916 Pathogenic MSH2 P43246 L187E 187 L E 0.896 Pathogenic MSH2 P43246 L187F 187 L F 0.45 Neutral MSH2 P43246 L187G 187 L G 0.814 Pathogenic MSH2 P43246 L187H 187 L H 0.794 Pathogenic MSH2 P43246 L187I 187 L I 0.182 Neutral MSH2 P43246 L187K 187 L K 0.732 Pathogenic MSH2 P43246 L187M 187 L M 0.73 Pathogenic MSH2 P43246 L187N 187 L N 0.788 Pathogenic MSH2 P43246 L187P 187 L P 0.986 Pathogenic 5 MSH2 P43246 L187Q 187 L Q 0.622 Pathogenic MSH2 P43246 L187R 187 L R 0.998 Pathogenic 5 MSH2 P43246 L187S 187 L S 0.346 Neutral MSH2 P43246 L187T 187 L T 0.116 Neutral MSH2 P43246 L187V 187 L V 0.08 Neutral MSH2 P43246 L187W 187 L W 0.914 Pathogenic MSH2 P43246 L187Y 187 L Y 0.874 Pathogenic MSH2 P43246 E188A 188 E A 0.81 Pathogenic MSH2 P43246 E188C 188 E C 0.766 Pathogenic MSH2 P43246 E188D 188 E D 0.894 Pathogenic MSH2 P43246 E188F 188 E F 0.96 Pathogenic MSH2 P43246 E188G 188 E G 0.314 Neutral MSH2 P43246 E188H 188 E H 0.752 Pathogenic MSH2 P43246 E188I 188 E I 0.984 Pathogenic MSH2 P43246 E188K 188 E K 0.77 Pathogenic MSH2 P43246 E188L 188 E L 0.974 Pathogenic MSH2 P43246 E188M 188 E M 0.914 Pathogenic MSH2 P43246 E188N 188 E N 0.494 Neutral MSH2 P43246 E188P 188 E P 0.94 Pathogenic MSH2 P43246 E188Q 188 E Q 0.854 Pathogenic MSH2 P43246 E188R 188 E R 0.934 Pathogenic MSH2 P43246 E188S 188 E S 0.374 Neutral MSH2 P43246 E188T 188 E T 0.842 Pathogenic MSH2 P43246 E188V 188 E V 0.924 Pathogenic MSH2 P43246 E188W 188 E W 0.98 Pathogenic MSH2 P43246 E188Y 188 E Y 0.946 Pathogenic MSH2 P43246 A189C 189 A C 0.866 Pathogenic MSH2 P43246 A189D 189 A D 0.88 Pathogenic MSH2 P43246 A189E 189 A E 0.914 Pathogenic MSH2 P43246 A189F 189 A F 0.964 Pathogenic MSH2 P43246 A189G 189 A G 0.156 Neutral MSH2 P43246 A189H 189 A H 0.874 Pathogenic MSH2 P43246 A189I 189 A I 0.914 Pathogenic MSH2 P43246 A189K 189 A K 0.924 Pathogenic MSH2 P43246 A189L 189 A L 0.966 Pathogenic MSH2 P43246 A189M 189 A M 0.838 Pathogenic MSH2 P43246 A189N 189 A N 0.842 Pathogenic MSH2 P43246 A189P 189 A P 0.944 Pathogenic MSH2 P43246 A189Q 189 A Q 0.864 Pathogenic MSH2 P43246 A189R 189 A R 0.93 Pathogenic MSH2 P43246 A189S 189 A S 0.264 Neutral MSH2 P43246 A189T 189 A T 0.202 Neutral MSH2 P43246 A189V 189 A V 0.586 Pathogenic MSH2 P43246 A189W 189 A W 0.964 Pathogenic MSH2 P43246 A189Y 189 A Y 0.926 Pathogenic MSH2 P43246 F19A 19 F A 0.506 Pathogenic MSH2 P43246 F19C 19 F C 0.718 Pathogenic MSH2 P43246 F19D 19 F D 0.8 Pathogenic MSH2 P43246 F19E 19 F E 0.846 Pathogenic MSH2 P43246 F19G 19 F G 0.506 Pathogenic MSH2 P43246 F19H 19 F H 0.752 Pathogenic MSH2 P43246 F19I 19 F I 0.304 Neutral MSH2 P43246 F19K 19 F K 0.83 Pathogenic MSH2 P43246 F19L 19 F L 0.234 Neutral MSH2 P43246 F19M 19 F M 0.774 Pathogenic MSH2 P43246 F19N 19 F N 0.738 Pathogenic MSH2 P43246 F19P 19 F P 0.482 Neutral MSH2 P43246 F19Q 19 F Q 0.748 Pathogenic MSH2 P43246 F19R 19 F R 0.896 Pathogenic MSH2 P43246 F19S 19 F S 0.862 Pathogenic MSH2 P43246 F19T 19 F T 0.574 Pathogenic MSH2 P43246 F19V 19 F V 0.764 Pathogenic MSH2 P43246 F19W 19 F W 0.846 Pathogenic MSH2 P43246 F19Y 19 F Y 0.534 Pathogenic MSH2 P43246 L190A 190 L A 0.012 Neutral MSH2 P43246 L190C 190 L C 0.134 Neutral MSH2 P43246 L190D 190 L D 0.244 Neutral MSH2 P43246 L190E 190 L E 0.22 Neutral MSH2 P43246 L190F 190 L F 0.16 Neutral MSH2 P43246 L190G 190 L G 0.264 Neutral MSH2 P43246 L190H 190 L H 0.126 Neutral MSH2 P43246 L190I 190 L I 0.124 Neutral MSH2 P43246 L190K 190 L K 0.166 Neutral MSH2 P43246 L190M 190 L M 0.256 Neutral MSH2 P43246 L190N 190 L N 0.236 Neutral MSH2 P43246 L190P 190 L P 0.34 Neutral MSH2 P43246 L190Q 190 L Q 0.104 Neutral MSH2 P43246 L190R 190 L R 0.492 Neutral MSH2 P43246 L190S 190 L S 0.28 Neutral MSH2 P43246 L190T 190 L T 0.164 Neutral MSH2 P43246 L190V 190 L V 0.022 Neutral MSH2 P43246 L190W 190 L W 0.524 Pathogenic MSH2 P43246 L190Y 190 L Y 0.484 Neutral MSH2 P43246 L191A 191 L A 0.14 Neutral MSH2 P43246 L191C 191 L C 0.144 Neutral MSH2 P43246 L191D 191 L D 0.252 Neutral MSH2 P43246 L191E 191 L E 0.228 Neutral MSH2 P43246 L191F 191 L F 0.448 Neutral MSH2 P43246 L191G 191 L G 0.27 Neutral MSH2 P43246 L191H 191 L H 0.132 Neutral MSH2 P43246 L191I 191 L I 0.004 Neutral MSH2 P43246 L191K 191 L K 0.286 Neutral MSH2 P43246 L191M 191 L M 0.012 Neutral MSH2 P43246 L191N 191 L N 0.248 Neutral MSH2 P43246 L191P 191 L P 0.344 Neutral MSH2 P43246 L191Q 191 L Q 0.11 Neutral MSH2 P43246 L191R 191 L R 0.54 Pathogenic MSH2 P43246 L191S 191 L S 0.196 Neutral MSH2 P43246 L191T 191 L T 0.174 Neutral MSH2 P43246 L191V 191 L V 0 Neutral MSH2 P43246 L191W 191 L W 0.572 Pathogenic MSH2 P43246 L191Y 191 L Y 0.532 Pathogenic MSH2 P43246 I192A 192 I A 0.186 Neutral MSH2 P43246 I192C 192 I C 0.234 Neutral MSH2 P43246 I192D 192 I D 0.726 Pathogenic MSH2 P43246 I192E 192 I E 0.738 Pathogenic MSH2 P43246 I192F 192 I F 0.946 Pathogenic MSH2 P43246 I192G 192 I G 0.792 Pathogenic MSH2 P43246 I192H 192 I H 0.888 Pathogenic MSH2 P43246 I192K 192 I K 0.834 Pathogenic MSH2 P43246 I192L 192 I L 0.116 Neutral MSH2 P43246 I192M 192 I M 0.244 Neutral MSH2 P43246 I192N 192 I N 0.53 Pathogenic MSH2 P43246 I192P 192 I P 0.914 Pathogenic MSH2 P43246 I192Q 192 I Q 0.768 Pathogenic MSH2 P43246 I192R 192 I R 0.864 Pathogenic MSH2 P43246 I192S 192 I S 0.608 Pathogenic MSH2 P43246 I192T 192 I T 0.296 Neutral MSH2 P43246 I192V 192 I V 0.184 Neutral MSH2 P43246 I192W 192 I W 0.98 Pathogenic MSH2 P43246 I192Y 192 I Y 0.966 Pathogenic MSH2 P43246 Q193A 193 Q A 0.258 Neutral MSH2 P43246 Q193C 193 Q C 0.71 Pathogenic MSH2 P43246 Q193D 193 Q D 0.422 Neutral MSH2 P43246 Q193E 193 Q E 0.868 Pathogenic MSH2 P43246 Q193F 193 Q F 0.932 Pathogenic MSH2 P43246 Q193G 193 Q G 0.304 Neutral MSH2 P43246 Q193H 193 Q H 0.464 Neutral MSH2 P43246 Q193I 193 Q I 0.622 Pathogenic MSH2 P43246 Q193K 193 Q K 0.976 Pathogenic MSH2 P43246 Q193L 193 Q L 0.438 Neutral MSH2 P43246 Q193M 193 Q M 0.926 Pathogenic MSH2 P43246 Q193N 193 Q N 0.824 Pathogenic MSH2 P43246 Q193P 193 Q P 0.92 Pathogenic MSH2 P43246 Q193R 193 Q R 0.604 Pathogenic MSH2 P43246 Q193S 193 Q S 0.312 Neutral MSH2 P43246 Q193T 193 Q T 0.21 Neutral MSH2 P43246 Q193V 193 Q V 0.674 Pathogenic MSH2 P43246 Q193W 193 Q W 0.964 Pathogenic MSH2 P43246 Q193Y 193 Q Y 0.952 Pathogenic MSH2 P43246 I194A 194 I A 0.526 Pathogenic MSH2 P43246 I194C 194 I C 0.366 Neutral MSH2 P43246 I194D 194 I D 0.736 Pathogenic MSH2 P43246 I194E 194 I E 0.748 Pathogenic MSH2 P43246 I194F 194 I F 0.586 Pathogenic MSH2 P43246 I194G 194 I G 0.798 Pathogenic MSH2 P43246 I194H 194 I H 0.89 Pathogenic MSH2 P43246 I194K 194 I K 0.844 Pathogenic MSH2 P43246 I194L 194 I L 0.202 Neutral MSH2 P43246 I194M 194 I M 0.198 Neutral MSH2 P43246 I194N 194 I N 0.536 Pathogenic MSH2 P43246 I194P 194 I P 0.922 Pathogenic MSH2 P43246 I194Q 194 I Q 0.544 Pathogenic MSH2 P43246 I194R 194 I R 0.868 Pathogenic MSH2 P43246 I194S 194 I S 0.616 Pathogenic MSH2 P43246 I194T 194 I T 0.102 Neutral MSH2 P43246 I194V 194 I V 0.146 Neutral MSH2 P43246 I194W 194 I W 0.986 Pathogenic MSH2 P43246 I194Y 194 I Y 0.976 Pathogenic MSH2 P43246 G195A 195 G A 0.338 Neutral MSH2 P43246 G195C 195 G C 0.764 Pathogenic MSH2 P43246 G195D 195 G D 0.638 Pathogenic MSH2 P43246 G195E 195 G E 0.984 Pathogenic MSH2 P43246 G195F 195 G F 0.986 Pathogenic MSH2 P43246 G195H 195 G H 0.99 Pathogenic MSH2 P43246 G195I 195 G I 0.976 Pathogenic MSH2 P43246 G195K 195 G K 0.878 Pathogenic MSH2 P43246 G195L 195 G L 0.986 Pathogenic MSH2 P43246 G195M 195 G M 0.996 Pathogenic MSH2 P43246 G195N 195 G N 0.682 Pathogenic MSH2 P43246 G195P 195 G P 0.976 Pathogenic MSH2 P43246 G195Q 195 G Q 0.738 Pathogenic MSH2 P43246 G195R 195 G R 0.872 Pathogenic MSH2 P43246 G195S 195 G S 0.266 Neutral MSH2 P43246 G195T 195 G T 0.89 Pathogenic MSH2 P43246 G195V 195 G V 0.988 Pathogenic MSH2 P43246 G195W 195 G W 0.982 Pathogenic MSH2 P43246 G195Y 195 G Y 0.976 Pathogenic MSH2 P43246 P196A 196 P A 0.162 Neutral MSH2 P43246 P196C 196 P C 0.168 Neutral MSH2 P43246 P196D 196 P D 0.796 Pathogenic MSH2 P43246 P196E 196 P E 0.982 Pathogenic MSH2 P43246 P196F 196 P F 0.994 Pathogenic MSH2 P43246 P196G 196 P G 0.526 Pathogenic MSH2 P43246 P196H 196 P H 0.992 Pathogenic MSH2 P43246 P196I 196 P I 0.316 Neutral MSH2 P43246 P196K 196 P K 0.964 Pathogenic MSH2 P43246 P196L 196 P L 0.976 Pathogenic MSH2 P43246 P196M 196 P M 0.972 Pathogenic MSH2 P43246 P196N 196 P N 0.644 Pathogenic MSH2 P43246 P196Q 196 P Q 0.872 Pathogenic MSH2 P43246 P196R 196 P R 0.998 Pathogenic MSH2 P43246 P196S 196 P S 0.372 Neutral MSH2 P43246 P196T 196 P T 0.418 Neutral MSH2 P43246 P196V 196 P V 0.244 Neutral MSH2 P43246 P196W 196 P W 0.928 Pathogenic MSH2 P43246 P196Y 196 P Y 0.922 Pathogenic MSH2 P43246 K197A 197 K A 0.688 Pathogenic MSH2 P43246 K197C 197 K C 0.57 Pathogenic MSH2 P43246 K197D 197 K D 0.758 Pathogenic MSH2 P43246 K197E 197 K E 0.858 Pathogenic MSH2 P43246 K197F 197 K F 0.942 Pathogenic MSH2 P43246 K197G 197 K G 0.53 Pathogenic MSH2 P43246 K197H 197 K H 0.858 Pathogenic MSH2 P43246 K197I 197 K I 0.976 Pathogenic MSH2 P43246 K197L 197 K L 0.968 Pathogenic MSH2 P43246 K197M 197 K M 0.848 Pathogenic MSH2 P43246 K197N 197 K N 0.772 Pathogenic MSH2 P43246 K197P 197 K P 0.908 Pathogenic MSH2 P43246 K197Q 197 K Q 0.842 Pathogenic MSH2 P43246 K197R 197 K R 0.236 Neutral MSH2 P43246 K197S 197 K S 0.288 Neutral MSH2 P43246 K197T 197 K T 0.272 Neutral MSH2 P43246 K197V 197 K V 0.842 Pathogenic MSH2 P43246 K197W 197 K W 0.976 Pathogenic MSH2 P43246 K197Y 197 K Y 0.962 Pathogenic MSH2 P43246 E198A 198 E A 0.802 Pathogenic MSH2 P43246 E198C 198 E C 0.762 Pathogenic MSH2 P43246 E198D 198 E D 0.888 Pathogenic MSH2 P43246 E198F 198 E F 0.952 Pathogenic MSH2 P43246 E198G 198 E G 0.288 Neutral 1 MSH2 P43246 E198H 198 E H 0.748 Pathogenic MSH2 P43246 E198I 198 E I 0.97 Pathogenic MSH2 P43246 E198K 198 E K 0.92 Pathogenic MSH2 P43246 E198L 198 E L 0.962 Pathogenic MSH2 P43246 E198M 198 E M 0.904 Pathogenic MSH2 P43246 E198N 198 E N 0.778 Pathogenic MSH2 P43246 E198P 198 E P 0.924 Pathogenic MSH2 P43246 E198Q 198 E Q 0.848 Pathogenic MSH2 P43246 E198R 198 E R 0.932 Pathogenic MSH2 P43246 E198S 198 E S 0.88 Pathogenic MSH2 P43246 E198T 198 E T 0.83 Pathogenic MSH2 P43246 E198V 198 E V 0.908 Pathogenic MSH2 P43246 E198W 198 E W 0.978 Pathogenic MSH2 P43246 E198Y 198 E Y 0.956 Pathogenic MSH2 P43246 C199A 199 C A 0.182 Neutral MSH2 P43246 C199D 199 C D 0.928 Pathogenic MSH2 P43246 C199E 199 C E 0.79 Pathogenic MSH2 P43246 C199F 199 C F 0.942 Pathogenic MSH2 P43246 C199G 199 C G 0.9 Pathogenic MSH2 P43246 C199H 199 C H 0.75 Pathogenic MSH2 P43246 C199I 199 C I 0.548 Pathogenic MSH2 P43246 C199K 199 C K 0.844 Pathogenic MSH2 P43246 C199L 199 C L 0.882 Pathogenic MSH2 P43246 C199M 199 C M 0.64 Pathogenic MSH2 P43246 C199N 199 C N 0.788 Pathogenic MSH2 P43246 C199P 199 C P 0.952 Pathogenic MSH2 P43246 C199Q 199 C Q 0.492 Neutral MSH2 P43246 C199R 199 C R 0.996 Pathogenic 5 MSH2 P43246 C199S 199 C S 0.364 Neutral MSH2 P43246 C199T 199 C T 0.538 Pathogenic MSH2 P43246 C199V 199 C V 0.288 Neutral MSH2 P43246 C199W 199 C W 0.954 Pathogenic MSH2 P43246 C199Y 199 C Y 0.94 Pathogenic MSH2 P43246 A2C 2 A C 0.204 Neutral MSH2 P43246 A2D 2 A D 0.316 Neutral MSH2 P43246 A2E 2 A E 0.298 Neutral MSH2 P43246 A2F 2 A F 0.526 Pathogenic MSH2 P43246 A2G 2 A G 0.126 Neutral MSH2 P43246 A2H 2 A H 0.352 Neutral MSH2 P43246 A2I 2 A I 0.504 Pathogenic MSH2 P43246 A2K 2 A K 0.408 Neutral MSH2 P43246 A2L 2 A L 0.452 Neutral MSH2 P43246 A2M 2 A M 0.338 Neutral MSH2 P43246 A2N 2 A N 0.322 Neutral MSH2 P43246 A2P 2 A P 0.304 Neutral MSH2 P43246 A2Q 2 A Q 0.332 Neutral MSH2 P43246 A2R 2 A R 0.418 Neutral MSH2 P43246 A2S 2 A S 0.068 Neutral MSH2 P43246 A2T 2 A T 0.016 Neutral MSH2 P43246 A2V 2 A V 0.264 Neutral MSH2 P43246 A2W 2 A W 0.56 Pathogenic MSH2 P43246 A2Y 2 A Y 0.544 Pathogenic MSH2 P43246 V20A 20 V A 0.152 Neutral MSH2 P43246 V20C 20 V C 0.046 Neutral MSH2 P43246 V20D 20 V D 0.546 Pathogenic MSH2 P43246 V20E 20 V E 0.664 Pathogenic MSH2 P43246 V20F 20 V F 0.47 Neutral MSH2 P43246 V20G 20 V G 0.592 Pathogenic MSH2 P43246 V20H 20 V H 0.5 Pathogenic MSH2 P43246 V20I 20 V I 0.066 Neutral MSH2 P43246 V20K 20 V K 0.74 Pathogenic MSH2 P43246 V20L 20 V L 0.066 Neutral MSH2 P43246 V20M 20 V M 0.284 Neutral MSH2 P43246 V20N 20 V N 0.582 Pathogenic MSH2 P43246 V20P 20 V P 0.816 Pathogenic MSH2 P43246 V20Q 20 V Q 0.558 Pathogenic MSH2 P43246 V20R 20 V R 0.618 Pathogenic MSH2 P43246 V20S 20 V S 0.402 Neutral MSH2 P43246 V20T 20 V T 0.132 Neutral MSH2 P43246 V20W 20 V W 0.814 Pathogenic MSH2 P43246 V20Y 20 V Y 0.464 Neutral MSH2 P43246 V200A 200 V A 0.322 Neutral MSH2 P43246 V200C 200 V C 0.72 Pathogenic MSH2 P43246 V200D 200 V D 0.86 Pathogenic 5 MSH2 P43246 V200E 200 V E 0.976 Pathogenic MSH2 P43246 V200F 200 V F 0.892 Pathogenic MSH2 P43246 V200G 200 V G 0.884 Pathogenic MSH2 P43246 V200H 200 V H 0.832 Pathogenic MSH2 P43246 V200I 200 V I 0.184 Neutral MSH2 P43246 V200K 200 V K 0.986 Pathogenic MSH2 P43246 V200L 200 V L 0.198 Neutral MSH2 P43246 V200M 200 V M 0.832 Pathogenic MSH2 P43246 V200N 200 V N 0.918 Pathogenic MSH2 P43246 V200P 200 V P 0.976 Pathogenic MSH2 P43246 V200Q 200 V Q 0.982 Pathogenic MSH2 P43246 V200R 200 V R 0.954 Pathogenic MSH2 P43246 V200S 200 V S 0.724 Pathogenic MSH2 P43246 V200T 200 V T 0.77 Pathogenic MSH2 P43246 V200W 200 V W 0.92 Pathogenic MSH2 P43246 V200Y 200 V Y 0.948 Pathogenic MSH2 P43246 L201A 201 L A 0.186 Neutral MSH2 P43246 L201C 201 L C 0.696 Pathogenic MSH2 P43246 L201D 201 L D 0.912 Pathogenic MSH2 P43246 L201E 201 L E 0.89 Pathogenic MSH2 P43246 L201F 201 L F 0.53 Pathogenic MSH2 P43246 L201G 201 L G 0.81 Pathogenic MSH2 P43246 L201H 201 L H 0.798 Pathogenic MSH2 P43246 L201I 201 L I 0.12 Neutral MSH2 P43246 L201K 201 L K 0.744 Pathogenic MSH2 P43246 L201M 201 L M 0.17 Neutral MSH2 P43246 L201N 201 L N 0.782 Pathogenic MSH2 P43246 L201P 201 L P 0.992 Pathogenic MSH2 P43246 L201Q 201 L Q 0.622 Pathogenic MSH2 P43246 L201R 201 L R 0.996 Pathogenic MSH2 P43246 L201S 201 L S 0.618 Pathogenic MSH2 P43246 L201T 201 L T 0.596 Pathogenic MSH2 P43246 L201V 201 L V 0.07 Neutral MSH2 P43246 L201W 201 L W 0.926 Pathogenic MSH2 P43246 L201Y 201 L Y 0.886 Pathogenic MSH2 P43246 P202A 202 P A 0.076 Neutral MSH2 P43246 P202C 202 P C 0.2 Neutral MSH2 P43246 P202D 202 P D 0.484 Neutral MSH2 P43246 P202E 202 P E 0.738 Pathogenic MSH2 P43246 P202F 202 P F 0.942 Pathogenic MSH2 P43246 P202G 202 P G 0.136 Neutral MSH2 P43246 P202H 202 P H 0.592 Pathogenic MSH2 P43246 P202I 202 P I 0.134 Neutral MSH2 P43246 P202K 202 P K 0.698 Pathogenic MSH2 P43246 P202L 202 P L 0.57 Pathogenic MSH2 P43246 P202M 202 P M 0.56 Pathogenic MSH2 P43246 P202N 202 P N 0.392 Neutral MSH2 P43246 P202Q 202 P Q 0.156 Neutral MSH2 P43246 P202R 202 P R 0.86 Pathogenic MSH2 P43246 P202S 202 P S 0.134 Neutral MSH2 P43246 P202T 202 P T 0.034 Neutral MSH2 P43246 P202V 202 P V 0.08 Neutral MSH2 P43246 P202W 202 P W 0.878 Pathogenic MSH2 P43246 P202Y 202 P Y 0.812 Pathogenic MSH2 P43246 G203A 203 G A 0.006 Neutral MSH2 P43246 G203C 203 G C 0.348 Neutral MSH2 P43246 G203D 203 G D 0.224 Neutral MSH2 P43246 G203E 203 G E 0.306 Neutral MSH2 P43246 G203F 203 G F 0.522 Pathogenic MSH2 P43246 G203H 203 G H 0.392 Neutral MSH2 P43246 G203I 203 G I 0.516 Pathogenic MSH2 P43246 G203K 203 G K 0.392 Neutral MSH2 P43246 G203L 203 G L 0.442 Neutral MSH2 P43246 G203M 203 G M 0.392 Neutral MSH2 P43246 G203N 203 G N 0.426 Neutral MSH2 P43246 G203P 203 G P 0.544 Pathogenic MSH2 P43246 G203Q 203 G Q 0.296 Neutral MSH2 P43246 G203R 203 G R 0.654 Pathogenic MSH2 P43246 G203S 203 G S 0.024 Neutral MSH2 P43246 G203T 203 G T 0.356 Neutral MSH2 P43246 G203V 203 G V 0.426 Neutral MSH2 P43246 G203W 203 G W 0.762 Pathogenic MSH2 P43246 G203Y 203 G Y 0.602 Pathogenic MSH2 P43246 G204A 204 G A 0.052 Neutral MSH2 P43246 G204C 204 G C 0.37 Neutral MSH2 P43246 G204D 204 G D 0.21 Neutral MSH2 P43246 G204E 204 G E 0.302 Neutral MSH2 P43246 G204F 204 G F 0.752 Pathogenic MSH2 P43246 G204H 204 G H 0.716 Pathogenic MSH2 P43246 G204I 204 G I 0.688 Pathogenic MSH2 P43246 G204K 204 G K 0.392 Neutral MSH2 P43246 G204L 204 G L 0.688 Pathogenic MSH2 P43246 G204M 204 G M 0.706 Pathogenic MSH2 P43246 G204N 204 G N 0.254 Neutral MSH2 P43246 G204P 204 G P 0.646 Pathogenic MSH2 P43246 G204Q 204 G Q 0.306 Neutral MSH2 P43246 G204R 204 G R 0.764 Pathogenic MSH2 P43246 G204S 204 G S 0.03 Neutral MSH2 P43246 G204T 204 G T 0.358 Neutral MSH2 P43246 G204V 204 G V 0.67 Pathogenic MSH2 P43246 G204W 204 G W 0.77 Pathogenic MSH2 P43246 G204Y 204 G Y 0.754 Pathogenic MSH2 P43246 E205A 205 E A 0.326 Neutral MSH2 P43246 E205C 205 E C 0.152 Neutral MSH2 P43246 E205D 205 E D 0.004 Neutral MSH2 P43246 E205F 205 E F 0.49 Neutral MSH2 P43246 E205G 205 E G 0.002 Neutral MSH2 P43246 E205H 205 E H 0.25 Neutral MSH2 P43246 E205I 205 E I 0.526 Pathogenic MSH2 P43246 E205K 205 E K 0.398 Neutral MSH2 P43246 E205L 205 E L 0.558 Pathogenic MSH2 P43246 E205M 205 E M 0.358 Neutral MSH2 P43246 E205N 205 E N 0.006 Neutral MSH2 P43246 E205P 205 E P 0.238 Neutral MSH2 P43246 E205Q 205 E Q 0.12 Neutral MSH2 P43246 E205R 205 E R 0.026 Neutral MSH2 P43246 E205S 205 E S 0.024 Neutral MSH2 P43246 E205T 205 E T 0.156 Neutral MSH2 P43246 E205V 205 E V 0.25 Neutral MSH2 P43246 E205W 205 E W 0.772 Pathogenic MSH2 P43246 E205Y 205 E Y 0.644 Pathogenic MSH2 P43246 T206A 206 T A 0 Neutral MSH2 P43246 T206C 206 T C 0.03 Neutral MSH2 P43246 T206D 206 T D 0.046 Neutral MSH2 P43246 T206E 206 T E 0.078 Neutral MSH2 P43246 T206F 206 T F 0.258 Neutral MSH2 P43246 T206G 206 T G 0.002 Neutral MSH2 P43246 T206H 206 T H 0.094 Neutral MSH2 P43246 T206I 206 T I 0.11 Neutral MSH2 P43246 T206K 206 T K 0.002 Neutral MSH2 P43246 T206L 206 T L 0.012 Neutral MSH2 P43246 T206M 206 T M 0.142 Neutral MSH2 P43246 T206N 206 T N 0 Neutral MSH2 P43246 T206P 206 T P 0.096 Neutral MSH2 P43246 T206Q 206 T Q 0.002 Neutral MSH2 P43246 T206R 206 T R 0.178 Neutral MSH2 P43246 T206S 206 T S 0 Neutral MSH2 P43246 T206V 206 T V 0.046 Neutral MSH2 P43246 T206W 206 T W 0.536 Pathogenic MSH2 P43246 T206Y 206 T Y 0.492 Neutral MSH2 P43246 A207C 207 A C 0.718 Pathogenic MSH2 P43246 A207D 207 A D 0.718 Pathogenic MSH2 P43246 A207E 207 A E 0.602 Pathogenic MSH2 P43246 A207F 207 A F 0.968 Pathogenic MSH2 P43246 A207G 207 A G 0.024 Neutral MSH2 P43246 A207H 207 A H 0.872 Pathogenic MSH2 P43246 A207I 207 A I 0.93 Pathogenic MSH2 P43246 A207K 207 A K 0.716 Pathogenic MSH2 P43246 A207L 207 A L 0.924 Pathogenic MSH2 P43246 A207M 207 A M 0.824 Pathogenic MSH2 P43246 A207N 207 A N 0.586 Pathogenic MSH2 P43246 A207P 207 A P 0.872 Pathogenic MSH2 P43246 A207Q 207 A Q 0.752 Pathogenic MSH2 P43246 A207R 207 A R 0.778 Pathogenic MSH2 P43246 A207S 207 A S 0.012 Neutral MSH2 P43246 A207T 207 A T 0.054 Neutral MSH2 P43246 A207V 207 A V 0.158 Neutral MSH2 P43246 A207W 207 A W 0.954 Pathogenic MSH2 P43246 A207Y 207 A Y 0.94 Pathogenic MSH2 P43246 G208A 208 G A 0.006 Neutral MSH2 P43246 G208C 208 G C 0.316 Neutral MSH2 P43246 G208D 208 G D 0.252 Neutral MSH2 P43246 G208E 208 G E 0.62 Pathogenic MSH2 P43246 G208F 208 G F 0.53 Pathogenic MSH2 P43246 G208H 208 G H 0.442 Neutral MSH2 P43246 G208I 208 G I 0.552 Pathogenic MSH2 P43246 G208K 208 G K 0.728 Pathogenic MSH2 P43246 G208L 208 G L 0.472 Neutral MSH2 P43246 G208M 208 G M 0.454 Neutral MSH2 P43246 G208N 208 G N 0.284 Neutral MSH2 P43246 G208P 208 G P 0.488 Neutral MSH2 P43246 G208Q 208 G Q 0.366 Neutral MSH2 P43246 G208R 208 G R 0.706 Pathogenic MSH2 P43246 G208S 208 G S 0.068 Neutral MSH2 P43246 G208T 208 G T 0.41 Neutral MSH2 P43246 G208V 208 G V 0.462 Neutral MSH2 P43246 G208W 208 G W 0.806 Pathogenic MSH2 P43246 G208Y 208 G Y 0.564 Pathogenic MSH2 P43246 D209A 209 D A 0.314 Neutral MSH2 P43246 D209C 209 D C 0.826 Pathogenic MSH2 P43246 D209E 209 D E 0.354 Neutral MSH2 P43246 D209F 209 D F 0.694 Pathogenic MSH2 P43246 D209G 209 D G 0.778 Pathogenic MSH2 P43246 D209H 209 D H 0.528 Pathogenic MSH2 P43246 D209I 209 D I 0.958 Pathogenic MSH2 P43246 D209K 209 D K 0.352 Neutral MSH2 P43246 D209L 209 D L 0.464 Neutral MSH2 P43246 D209M 209 D M 0.902 Pathogenic MSH2 P43246 D209N 209 D N 0.088 Neutral MSH2 P43246 D209P 209 D P 0.864 Pathogenic MSH2 P43246 D209Q 209 D Q 0.228 Neutral MSH2 P43246 D209R 209 D R 0.504 Pathogenic MSH2 P43246 D209S 209 D S 0.644 Pathogenic MSH2 P43246 D209T 209 D T 0.412 Neutral MSH2 P43246 D209V 209 D V 0.974 Pathogenic MSH2 P43246 D209W 209 D W 0.978 Pathogenic MSH2 P43246 D209Y 209 D Y 0.972 Pathogenic MSH2 P43246 R21A 21 R A 0.134 Neutral MSH2 P43246 R21C 21 R C 0.61 Pathogenic MSH2 P43246 R21D 21 R D 0.114 Neutral MSH2 P43246 R21E 21 R E 0.06 Neutral MSH2 P43246 R21F 21 R F 0.862 Pathogenic MSH2 P43246 R21G 21 R G 0.242 Neutral MSH2 P43246 R21H 21 R H 0.316 Neutral MSH2 P43246 R21I 21 R I 0.876 Pathogenic MSH2 P43246 R21K 21 R K 0.056 Neutral MSH2 P43246 R21L 21 R L 0.842 Pathogenic MSH2 P43246 R21M 21 R M 0.626 Pathogenic MSH2 P43246 R21N 21 R N 0.022 Neutral MSH2 P43246 R21P 21 R P 0.736 Pathogenic MSH2 P43246 R21Q 21 R Q 0.03 Neutral MSH2 P43246 R21S 21 R S 0.044 Neutral MSH2 P43246 R21T 21 R T 0.046 Neutral MSH2 P43246 R21V 21 R V 0.44 Neutral MSH2 P43246 R21W 21 R W 0.856 Pathogenic MSH2 P43246 R21Y 21 R Y 0.828 Pathogenic MSH2 P43246 M210A 210 M A 0.164 Neutral MSH2 P43246 M210C 210 M C 0.172 Neutral MSH2 P43246 M210D 210 M D 0.576 Pathogenic MSH2 P43246 M210E 210 M E 0.34 Neutral MSH2 P43246 M210F 210 M F 0.114 Neutral MSH2 P43246 M210G 210 M G 0.108 Neutral MSH2 P43246 M210H 210 M H 0.378 Neutral MSH2 P43246 M210I 210 M I 0.234 Neutral MSH2 P43246 M210K 210 M K 0.162 Neutral MSH2 P43246 M210L 210 M L 0.162 Neutral MSH2 P43246 M210N 210 M N 0.586 Pathogenic MSH2 P43246 M210P 210 M P 0.166 Neutral MSH2 P43246 M210Q 210 M Q 0.176 Neutral MSH2 P43246 M210R 210 M R 0.312 Neutral MSH2 P43246 M210S 210 M S 0.074 Neutral MSH2 P43246 M210T 210 M T 0.052 Neutral MSH2 P43246 M210V 210 M V 0.388 Neutral MSH2 P43246 M210W 210 M W 0.916 Pathogenic MSH2 P43246 M210Y 210 M Y 0.228 Neutral MSH2 P43246 G211A 211 G A 0.016 Neutral MSH2 P43246 G211C 211 G C 0.414 Neutral MSH2 P43246 G211D 211 G D 0.374 Neutral MSH2 P43246 G211E 211 G E 0.35 Neutral MSH2 P43246 G211F 211 G F 0.808 Pathogenic MSH2 P43246 G211H 211 G H 0.434 Neutral MSH2 P43246 G211I 211 G I 0.548 Pathogenic MSH2 P43246 G211K 211 G K 0.432 Neutral MSH2 P43246 G211L 211 G L 0.722 Pathogenic MSH2 P43246 G211M 211 G M 0.736 Pathogenic MSH2 P43246 G211N 211 G N 0.286 Neutral MSH2 P43246 G211P 211 G P 0.684 Pathogenic MSH2 P43246 G211Q 211 G Q 0.334 Neutral MSH2 P43246 G211R 211 G R 0.44 Neutral MSH2 P43246 G211S 211 G S 0.028 Neutral MSH2 P43246 G211T 211 G T 0.4 Neutral MSH2 P43246 G211V 211 G V 0.468 Neutral MSH2 P43246 G211W 211 G W 0.806 Pathogenic MSH2 P43246 G211Y 211 G Y 0.792 Pathogenic MSH2 P43246 K212A 212 K A 0.114 Neutral MSH2 P43246 K212C 212 K C 0.432 Neutral MSH2 P43246 K212D 212 K D 0.6 Pathogenic MSH2 P43246 K212E 212 K E 0.256 Neutral MSH2 P43246 K212F 212 K F 0.936 Pathogenic MSH2 P43246 K212G 212 K G 0.548 Pathogenic MSH2 P43246 K212H 212 K H 0.716 Pathogenic MSH2 P43246 K212I 212 K I 0.728 Pathogenic MSH2 P43246 K212L 212 K L 0.972 Pathogenic MSH2 P43246 K212M 212 K M 0.884 Pathogenic MSH2 P43246 K212N 212 K N 0.16 Neutral MSH2 P43246 K212P 212 K P 0.418 Neutral MSH2 P43246 K212Q 212 K Q 0.124 Neutral MSH2 P43246 K212R 212 K R 0.14 Neutral MSH2 P43246 K212S 212 K S 0.142 Neutral MSH2 P43246 K212T 212 K T 0.126 Neutral MSH2 P43246 K212V 212 K V 0.858 Pathogenic MSH2 P43246 K212W 212 K W 0.982 Pathogenic MSH2 P43246 K212Y 212 K Y 0.88 Pathogenic MSH2 P43246 L213A 213 L A 0.63 Pathogenic MSH2 P43246 L213C 213 L C 0.756 Pathogenic MSH2 P43246 L213D 213 L D 0.884 Pathogenic MSH2 P43246 L213E 213 L E 0.864 Pathogenic MSH2 P43246 L213F 213 L F 0.658 Pathogenic MSH2 P43246 L213G 213 L G 0.796 Pathogenic MSH2 P43246 L213H 213 L H 0.874 Pathogenic MSH2 P43246 L213I 213 L I 0.192 Neutral MSH2 P43246 L213K 213 L K 0.75 Pathogenic MSH2 P43246 L213M 213 L M 0.268 Neutral MSH2 P43246 L213N 213 L N 0.748 Pathogenic MSH2 P43246 L213P 213 L P 0.686 Pathogenic MSH2 P43246 L213Q 213 L Q 0.684 Pathogenic MSH2 P43246 L213R 213 L R 0.984 Pathogenic MSH2 P43246 L213S 213 L S 0.626 Pathogenic MSH2 P43246 L213T 213 L T 0.328 Neutral MSH2 P43246 L213V 213 L V 0.068 Neutral MSH2 P43246 L213W 213 L W 0.944 Pathogenic MSH2 P43246 L213Y 213 L Y 0.904 Pathogenic MSH2 P43246 R214A 214 R A 0.338 Neutral MSH2 P43246 R214C 214 R C 0.482 Neutral MSH2 P43246 R214D 214 R D 0.088 Neutral MSH2 P43246 R214E 214 R E 0.072 Neutral MSH2 P43246 R214F 214 R F 0.942 Pathogenic MSH2 P43246 R214G 214 R G 0.212 Neutral MSH2 P43246 R214H 214 R H 0.032 Neutral MSH2 P43246 R214I 214 R I 0.188 Neutral MSH2 P43246 R214K 214 R K 0.056 Neutral MSH2 P43246 R214L 214 R L 0.364 Neutral MSH2 P43246 R214M 214 R M 0.554 Pathogenic MSH2 P43246 R214N 214 R N 0.14 Neutral MSH2 P43246 R214P 214 R P 0.852 Pathogenic MSH2 P43246 R214Q 214 R Q 0.018 Neutral MSH2 P43246 R214S 214 R S 0.13 Neutral MSH2 P43246 R214T 214 R T 0.07 Neutral MSH2 P43246 R214V 214 R V 0.362 Neutral MSH2 P43246 R214W 214 R W 0.918 Pathogenic MSH2 P43246 R214Y 214 R Y 0.172 Neutral MSH2 P43246 Q215A 215 Q A 0.178 Neutral MSH2 P43246 Q215C 215 Q C 0.444 Neutral MSH2 P43246 Q215D 215 Q D 0.07 Neutral MSH2 P43246 Q215E 215 Q E 0.054 Neutral MSH2 P43246 Q215F 215 Q F 0.784 Pathogenic MSH2 P43246 Q215G 215 Q G 0.138 Neutral MSH2 P43246 Q215H 215 Q H 0.47 Neutral MSH2 P43246 Q215I 215 Q I 0.826 Pathogenic MSH2 P43246 Q215K 215 Q K 0.086 Neutral MSH2 P43246 Q215L 215 Q L 0.72 Pathogenic MSH2 P43246 Q215M 215 Q M 0.428 Neutral MSH2 P43246 Q215N 215 Q N 0.118 Neutral MSH2 P43246 Q215P 215 Q P 0.838 Pathogenic MSH2 P43246 Q215R 215 Q R 0.474 Neutral MSH2 P43246 Q215S 215 Q S 0.12 Neutral MSH2 P43246 Q215T 215 Q T 0.058 Neutral MSH2 P43246 Q215V 215 Q V 0.78 Pathogenic MSH2 P43246 Q215W 215 Q W 0.902 Pathogenic MSH2 P43246 Q215Y 215 Q Y 0.858 Pathogenic MSH2 P43246 I216A 216 I A 0.106 Neutral MSH2 P43246 I216C 216 I C 0.624 Pathogenic MSH2 P43246 I216D 216 I D 0.78 Pathogenic MSH2 P43246 I216E 216 I E 0.788 Pathogenic MSH2 P43246 I216F 216 I F 0.862 Pathogenic MSH2 P43246 I216G 216 I G 0.808 Pathogenic MSH2 P43246 I216H 216 I H 0.83 Pathogenic MSH2 P43246 I216K 216 I K 0.194 Neutral MSH2 P43246 I216L 216 I L 0.08 Neutral MSH2 P43246 I216M 216 I M 0.15 Neutral MSH2 P43246 I216N 216 I N 0.806 Pathogenic MSH2 P43246 I216P 216 I P 0.902 Pathogenic MSH2 P43246 I216Q 216 I Q 0.816 Pathogenic MSH2 P43246 I216R 216 I R 0.894 Pathogenic MSH2 P43246 I216S 216 I S 0.176 Neutral MSH2 P43246 I216T 216 I T 0.288 Neutral MSH2 P43246 I216V 216 I V 0.278 Neutral MSH2 P43246 I216W 216 I W 0.906 Pathogenic MSH2 P43246 I216Y 216 I Y 0.9 Pathogenic MSH2 P43246 I217A 217 I A 0.048 Neutral MSH2 P43246 I217C 217 I C 0.166 Neutral MSH2 P43246 I217D 217 I D 0.624 Pathogenic MSH2 P43246 I217E 217 I E 0.608 Pathogenic MSH2 P43246 I217F 217 I F 0.188 Neutral MSH2 P43246 I217G 217 I G 0.486 Neutral MSH2 P43246 I217H 217 I H 0.508 Pathogenic MSH2 P43246 I217K 217 I K 0.616 Pathogenic MSH2 P43246 I217L 217 I L 0.008 Neutral MSH2 P43246 I217M 217 I M 0.038 Neutral MSH2 P43246 I217N 217 I N 0.666 Pathogenic MSH2 P43246 I217P 217 I P 0.75 Pathogenic MSH2 P43246 I217Q 217 I Q 0.642 Pathogenic MSH2 P43246 I217R 217 I R 0.822 Pathogenic MSH2 P43246 I217S 217 I S 0.416 Neutral MSH2 P43246 I217T 217 I T 0.338 Neutral MSH2 P43246 I217V 217 I V 0.004 Neutral MSH2 P43246 I217W 217 I W 0.87 Pathogenic MSH2 P43246 I217Y 217 I Y 0.864 Pathogenic MSH2 P43246 Q218A 218 Q A 0.14 Neutral MSH2 P43246 Q218C 218 Q C 0.48 Neutral MSH2 P43246 Q218D 218 Q D 0.024 Neutral MSH2 P43246 Q218E 218 Q E 0.028 Neutral MSH2 P43246 Q218F 218 Q F 0.842 Pathogenic MSH2 P43246 Q218G 218 Q G 0.424 Neutral MSH2 P43246 Q218H 218 Q H 0.812 Pathogenic MSH2 P43246 Q218I 218 Q I 0.896 Pathogenic MSH2 P43246 Q218K 218 Q K 0.064 Neutral MSH2 P43246 Q218L 218 Q L 0.306 Neutral MSH2 P43246 Q218M 218 Q M 0.748 Pathogenic MSH2 P43246 Q218N 218 Q N 0.108 Neutral MSH2 P43246 Q218P 218 Q P 0.86 Pathogenic MSH2 P43246 Q218R 218 Q R 0.568 Pathogenic MSH2 P43246 Q218S 218 Q S 0.09 Neutral MSH2 P43246 Q218T 218 Q T 0.026 Neutral MSH2 P43246 Q218V 218 Q V 0.388 Neutral MSH2 P43246 Q218W 218 Q W 0.932 Pathogenic MSH2 P43246 Q218Y 218 Q Y 0.894 Pathogenic MSH2 P43246 R219A 219 R A 0.266 Neutral MSH2 P43246 R219C 219 R C 0.944 Pathogenic MSH2 P43246 R219D 219 R D 0.236 Neutral MSH2 P43246 R219E 219 R E 0.37 Neutral MSH2 P43246 R219F 219 R F 0.968 Pathogenic MSH2 P43246 R219G 219 R G 0.412 Neutral MSH2 P43246 R219H 219 R H 0.564 Pathogenic MSH2 P43246 R219I 219 R I 0.97 Pathogenic MSH2 P43246 R219K 219 R K 0.36 Neutral MSH2 P43246 R219L 219 R L 0.678 Pathogenic MSH2 P43246 R219M 219 R M 0.798 Pathogenic MSH2 P43246 R219N 219 R N 0.122 Neutral MSH2 P43246 R219P 219 R P 0.98 Pathogenic MSH2 P43246 R219Q 219 R Q 0.354 Neutral MSH2 P43246 R219S 219 R S 0.16 Neutral MSH2 P43246 R219T 219 R T 0.234 Neutral MSH2 P43246 R219V 219 R V 0.968 Pathogenic MSH2 P43246 R219W 219 R W 0.902 Pathogenic MSH2 P43246 R219Y 219 R Y 0.97 Pathogenic MSH2 P43246 F22A 22 F A 0.122 Neutral MSH2 P43246 F22C 22 F C 0.132 Neutral MSH2 P43246 F22D 22 F D 0.564 Pathogenic MSH2 P43246 F22E 22 F E 0.662 Pathogenic MSH2 P43246 F22G 22 F G 0.354 Neutral MSH2 P43246 F22H 22 F H 0.37 Neutral MSH2 P43246 F22I 22 F I 0.252 Neutral MSH2 P43246 F22K 22 F K 0.122 Neutral MSH2 P43246 F22L 22 F L 0.184 Neutral MSH2 P43246 F22M 22 F M 0.388 Neutral MSH2 P43246 F22N 22 F N 0.242 Neutral MSH2 P43246 F22P 22 F P 0.712 Pathogenic MSH2 P43246 F22Q 22 F Q 0.452 Neutral MSH2 P43246 F22R 22 F R 0.094 Neutral MSH2 P43246 F22S 22 F S 0.352 Neutral MSH2 P43246 F22T 22 F T 0.044 Neutral MSH2 P43246 F22V 22 F V 0.146 Neutral MSH2 P43246 F22W 22 F W 0.612 Pathogenic MSH2 P43246 F22Y 22 F Y 0.044 Neutral MSH2 P43246 G220A 220 G A 0.31 Neutral MSH2 P43246 G220C 220 G C 0.588 Pathogenic MSH2 P43246 G220D 220 G D 0.956 Pathogenic MSH2 P43246 G220E 220 G E 0.978 Pathogenic MSH2 P43246 G220F 220 G F 0.924 Pathogenic MSH2 P43246 G220H 220 G H 0.898 Pathogenic MSH2 P43246 G220I 220 G I 0.972 Pathogenic MSH2 P43246 G220K 220 G K 0.982 Pathogenic MSH2 P43246 G220L 220 G L 0.982 Pathogenic MSH2 P43246 G220M 220 G M 0.988 Pathogenic MSH2 P43246 G220N 220 G N 0.492 Neutral MSH2 P43246 G220P 220 G P 0.968 Pathogenic MSH2 P43246 G220Q 220 G Q 0.96 Pathogenic MSH2 P43246 G220R 220 G R 0.996 Pathogenic MSH2 P43246 G220S 220 G S 0.296 Neutral MSH2 P43246 G220T 220 G T 0.714 Pathogenic MSH2 P43246 G220V 220 G V 0.982 Pathogenic MSH2 P43246 G220W 220 G W 0.972 Pathogenic MSH2 P43246 G220Y 220 G Y 0.912 Pathogenic MSH2 P43246 G221A 221 G A 0.656 Pathogenic MSH2 P43246 G221C 221 G C 0.776 Pathogenic MSH2 P43246 G221D 221 G D 0.564 Pathogenic MSH2 P43246 G221E 221 G E 0.816 Pathogenic MSH2 P43246 G221F 221 G F 0.988 Pathogenic MSH2 P43246 G221H 221 G H 0.992 Pathogenic MSH2 P43246 G221I 221 G I 0.978 Pathogenic MSH2 P43246 G221K 221 G K 0.906 Pathogenic MSH2 P43246 G221L 221 G L 0.988 Pathogenic MSH2 P43246 G221M 221 G M 0.994 Pathogenic MSH2 P43246 G221N 221 G N 0.5 Pathogenic MSH2 P43246 G221P 221 G P 0.982 Pathogenic MSH2 P43246 G221Q 221 G Q 0.988 Pathogenic MSH2 P43246 G221R 221 G R 0.704 Pathogenic MSH2 P43246 G221S 221 G S 0.344 Neutral MSH2 P43246 G221T 221 G T 0.918 Pathogenic MSH2 P43246 G221V 221 G V 0.99 Pathogenic MSH2 P43246 G221W 221 G W 0.984 Pathogenic MSH2 P43246 G221Y 221 G Y 0.986 Pathogenic MSH2 P43246 I222A 222 I A 0.11 Neutral MSH2 P43246 I222C 222 I C 0.126 Neutral MSH2 P43246 I222D 222 I D 0.782 Pathogenic MSH2 P43246 I222E 222 I E 0.79 Pathogenic MSH2 P43246 I222F 222 I F 0.86 Pathogenic MSH2 P43246 I222G 222 I G 0.5 Pathogenic MSH2 P43246 I222H 222 I H 0.828 Pathogenic MSH2 P43246 I222K 222 I K 0.852 Pathogenic MSH2 P43246 I222L 222 I L 0.1 Neutral MSH2 P43246 I222M 222 I M 0.154 Neutral MSH2 P43246 I222N 222 I N 0.808 Pathogenic MSH2 P43246 I222P 222 I P 0.902 Pathogenic MSH2 P43246 I222Q 222 I Q 0.818 Pathogenic MSH2 P43246 I222R 222 I R 0.896 Pathogenic MSH2 P43246 I222S 222 I S 0.18 Neutral MSH2 P43246 I222T 222 I T 0.17 Neutral MSH2 P43246 I222V 222 I V 0.282 Neutral MSH2 P43246 I222W 222 I W 0.902 Pathogenic MSH2 P43246 I222Y 222 I Y 0.898 Pathogenic MSH2 P43246 L223A 223 L A 0.042 Neutral MSH2 P43246 L223C 223 L C 0.392 Neutral MSH2 P43246 L223D 223 L D 0.666 Pathogenic MSH2 P43246 L223E 223 L E 0.622 Pathogenic MSH2 P43246 L223F 223 L F 0.8 Pathogenic MSH2 P43246 L223G 223 L G 0.282 Neutral MSH2 P43246 L223H 223 L H 0.418 Neutral MSH2 P43246 L223I 223 L I 0.06 Neutral MSH2 P43246 L223K 223 L K 0.48 Neutral MSH2 P43246 L223M 223 L M 0.01 Neutral MSH2 P43246 L223N 223 L N 0.614 Pathogenic MSH2 P43246 L223P 223 L P 0.338 Neutral MSH2 P43246 L223Q 223 L Q 0.36 Neutral MSH2 P43246 L223R 223 L R 0.75 Pathogenic MSH2 P43246 L223S 223 L S 0.17 Neutral MSH2 P43246 L223T 223 L T 0.172 Neutral MSH2 P43246 L223V 223 L V 0.006 Neutral MSH2 P43246 L223W 223 L W 0.852 Pathogenic MSH2 P43246 L223Y 223 L Y 0.842 Pathogenic MSH2 P43246 I224A 224 I A 0.114 Neutral MSH2 P43246 I224C 224 I C 0.342 Neutral MSH2 P43246 I224D 224 I D 0.506 Pathogenic MSH2 P43246 I224E 224 I E 0.77 Pathogenic MSH2 P43246 I224F 224 I F 0.328 Neutral MSH2 P43246 I224G 224 I G 0.518 Pathogenic MSH2 P43246 I224H 224 I H 0.408 Neutral MSH2 P43246 I224K 224 I K 0.502 Pathogenic MSH2 P43246 I224L 224 I L 0.088 Neutral MSH2 P43246 I224M 224 I M 0.144 Neutral MSH2 P43246 I224N 224 I N 0.802 Pathogenic MSH2 P43246 I224P 224 I P 0.866 Pathogenic MSH2 P43246 I224Q 224 I Q 0.798 Pathogenic MSH2 P43246 I224R 224 I R 0.88 Pathogenic MSH2 P43246 I224S 224 I S 0.56 Pathogenic MSH2 P43246 I224T 224 I T 0.306 Neutral MSH2 P43246 I224V 224 I V 0.182 Neutral MSH2 P43246 I224W 224 I W 0.74 Pathogenic MSH2 P43246 I224Y 224 I Y 0.836 Pathogenic MSH2 P43246 T225A 225 T A 0.166 Neutral MSH2 P43246 T225C 225 T C 0.884 Pathogenic MSH2 P43246 T225D 225 T D 0.898 Pathogenic MSH2 P43246 T225E 225 T E 0.938 Pathogenic MSH2 P43246 T225F 225 T F 0.604 Pathogenic MSH2 P43246 T225G 225 T G 0.65 Pathogenic MSH2 P43246 T225H 225 T H 0.886 Pathogenic MSH2 P43246 T225I 225 T I 0.928 Pathogenic MSH2 P43246 T225K 225 T K 0.912 Pathogenic MSH2 P43246 T225L 225 T L 0.918 Pathogenic MSH2 P43246 T225M 225 T M 0.978 Pathogenic MSH2 P43246 T225N 225 T N 0.33 Neutral MSH2 P43246 T225P 225 T P 0.944 Pathogenic MSH2 P43246 T225Q 225 T Q 0.836 Pathogenic MSH2 P43246 T225R 225 T R 0.968 Pathogenic MSH2 P43246 T225S 225 T S 0.112 Neutral MSH2 P43246 T225V 225 T V 0.728 Pathogenic MSH2 P43246 T225W 225 T W 0.994 Pathogenic MSH2 P43246 T225Y 225 T Y 0.994 Pathogenic MSH2 P43246 E226A 226 E A 0.392 Neutral MSH2 P43246 E226C 226 E C 0.578 Pathogenic MSH2 P43246 E226D 226 E D 0.076 Neutral MSH2 P43246 E226F 226 E F 0.37 Neutral MSH2 P43246 E226G 226 E G 0.132 Neutral MSH2 P43246 E226H 226 E H 0.276 Neutral MSH2 P43246 E226I 226 E I 0.45 Neutral MSH2 P43246 E226K 226 E K 0.45 Neutral MSH2 P43246 E226L 226 E L 0.31 Neutral MSH2 P43246 E226M 226 E M 0.614 Pathogenic MSH2 P43246 E226N 226 E N 0.184 Neutral MSH2 P43246 E226P 226 E P 0.434 Neutral MSH2 P43246 E226Q 226 E Q 0.114 Neutral MSH2 P43246 E226R 226 E R 0.46 Neutral MSH2 P43246 E226S 226 E S 0.146 Neutral MSH2 P43246 E226T 226 E T 0.162 Neutral MSH2 P43246 E226V 226 E V 0.296 Neutral MSH2 P43246 E226W 226 E W 0.922 Pathogenic MSH2 P43246 E226Y 226 E Y 0.888 Pathogenic MSH2 P43246 R227A 227 R A 0.272 Neutral MSH2 P43246 R227C 227 R C 0.938 Pathogenic MSH2 P43246 R227D 227 R D 0.852 Pathogenic MSH2 P43246 R227E 227 R E 0.828 Pathogenic MSH2 P43246 R227F 227 R F 0.964 Pathogenic MSH2 P43246 R227G 227 R G 0.412 Neutral MSH2 P43246 R227H 227 R H 0.558 Pathogenic MSH2 P43246 R227I 227 R I 0.43 Neutral MSH2 P43246 R227K 227 R K 0.352 Neutral MSH2 P43246 R227L 227 R L 0.36 Neutral MSH2 P43246 R227M 227 R M 0.792 Pathogenic MSH2 P43246 R227N 227 R N 0.136 Neutral MSH2 P43246 R227P 227 R P 0.374 Neutral MSH2 P43246 R227Q 227 R Q 0.606 Pathogenic MSH2 P43246 R227S 227 R S 0.364 Neutral MSH2 P43246 R227T 227 R T 0.376 Neutral MSH2 P43246 R227V 227 R V 0.328 Neutral MSH2 P43246 R227W 227 R W 0.97 Pathogenic MSH2 P43246 R227Y 227 R Y 0.966 Pathogenic MSH2 P43246 K228A 228 K A 0.104 Neutral MSH2 P43246 K228C 228 K C 0.432 Neutral MSH2 P43246 K228D 228 K D 0.604 Pathogenic MSH2 P43246 K228E 228 K E 0.714 Pathogenic MSH2 P43246 K228F 228 K F 0.964 Pathogenic MSH2 P43246 K228G 228 K G 0.21 Neutral MSH2 P43246 K228H 228 K H 0.132 Neutral MSH2 P43246 K228I 228 K I 0.988 Pathogenic MSH2 P43246 K228L 228 K L 0.978 Pathogenic MSH2 P43246 K228M 228 K M 0.922 Pathogenic MSH2 P43246 K228N 228 K N 0.648 Pathogenic MSH2 P43246 K228P 228 K P 0.31 Neutral MSH2 P43246 K228Q 228 K Q 0.276 Neutral MSH2 P43246 K228R 228 K R 0.136 Neutral MSH2 P43246 K228S 228 K S 0.142 Neutral MSH2 P43246 K228T 228 K T 0.62 Pathogenic MSH2 P43246 K228V 228 K V 0.878 Pathogenic MSH2 P43246 K228W 228 K W 0.992 Pathogenic MSH2 P43246 K228Y 228 K Y 0.984 Pathogenic MSH2 P43246 K229A 229 K A 0.068 Neutral MSH2 P43246 K229C 229 K C 0.16 Neutral MSH2 P43246 K229D 229 K D 0.258 Neutral MSH2 P43246 K229E 229 K E 0.298 Neutral MSH2 P43246 K229F 229 K F 0.822 Pathogenic MSH2 P43246 K229G 229 K G 0.15 Neutral MSH2 P43246 K229H 229 K H 0.328 Neutral MSH2 P43246 K229I 229 K I 0.236 Neutral MSH2 P43246 K229L 229 K L 0.42 Neutral MSH2 P43246 K229M 229 K M 0.084 Neutral MSH2 P43246 K229N 229 K N 0.028 Neutral MSH2 P43246 K229P 229 K P 0.08 Neutral MSH2 P43246 K229Q 229 K Q 0.048 Neutral MSH2 P43246 K229R 229 K R 0.03 Neutral MSH2 P43246 K229S 229 K S 0.03 Neutral MSH2 P43246 K229T 229 K T 0.384 Neutral MSH2 P43246 K229V 229 K V 0.114 Neutral MSH2 P43246 K229W 229 K W 0.976 Pathogenic MSH2 P43246 K229Y 229 K Y 0.924 Pathogenic MSH2 P43246 F23A 23 F A 0.402 Neutral MSH2 P43246 F23C 23 F C 0.218 Neutral MSH2 P43246 F23D 23 F D 0.806 Pathogenic MSH2 P43246 F23E 23 F E 0.91 Pathogenic MSH2 P43246 F23G 23 F G 0.338 Neutral MSH2 P43246 F23H 23 F H 0.098 Neutral MSH2 P43246 F23I 23 F I 0.126 Neutral MSH2 P43246 F23K 23 F K 0.87 Pathogenic MSH2 P43246 F23L 23 F L 0.102 Neutral MSH2 P43246 F23M 23 F M 0.602 Pathogenic MSH2 P43246 F23N 23 F N 0.74 Pathogenic MSH2 P43246 F23P 23 F P 0.856 Pathogenic MSH2 P43246 F23Q 23 F Q 0.78 Pathogenic MSH2 P43246 F23R 23 F R 0.912 Pathogenic MSH2 P43246 F23S 23 F S 0.652 Pathogenic MSH2 P43246 F23T 23 F T 0.52 Pathogenic MSH2 P43246 F23V 23 F V 0.174 Neutral MSH2 P43246 F23W 23 F W 0.806 Pathogenic MSH2 P43246 F23Y 23 F Y 0.204 Neutral MSH2 P43246 A230C 230 A C 0.738 Pathogenic MSH2 P43246 A230D 230 A D 0.848 Pathogenic MSH2 P43246 A230E 230 A E 0.87 Pathogenic MSH2 P43246 A230F 230 A F 0.966 Pathogenic MSH2 P43246 A230G 230 A G 0.02 Neutral MSH2 P43246 A230H 230 A H 0.802 Pathogenic MSH2 P43246 A230I 230 A I 0.926 Pathogenic MSH2 P43246 A230K 230 A K 0.69 Pathogenic MSH2 P43246 A230L 230 A L 0.95 Pathogenic MSH2 P43246 A230M 230 A M 0.68 Pathogenic MSH2 P43246 A230N 230 A N 0.596 Pathogenic MSH2 P43246 A230P 230 A P 0.916 Pathogenic MSH2 P43246 A230Q 230 A Q 0.532 Pathogenic MSH2 P43246 A230R 230 A R 0.678 Pathogenic MSH2 P43246 A230S 230 A S 0.052 Neutral MSH2 P43246 A230T 230 A T 0.036 Neutral MSH2 P43246 A230V 230 A V 0.134 Neutral MSH2 P43246 A230W 230 A W 0.956 Pathogenic MSH2 P43246 A230Y 230 A Y 0.94 Pathogenic MSH2 P43246 D231A 231 D A 0.22 Neutral MSH2 P43246 D231C 231 D C 0.904 Pathogenic MSH2 P43246 D231E 231 D E 0.334 Neutral MSH2 P43246 D231F 231 D F 0.984 Pathogenic MSH2 P43246 D231G 231 D G 0.89 Pathogenic MSH2 P43246 D231H 231 D H 0.612 Pathogenic MSH2 P43246 D231I 231 D I 0.966 Pathogenic MSH2 P43246 D231K 231 D K 0.968 Pathogenic MSH2 P43246 D231L 231 D L 0.768 Pathogenic MSH2 P43246 D231M 231 D M 0.944 Pathogenic MSH2 P43246 D231N 231 D N 0.14 Neutral MSH2 P43246 D231P 231 D P 0.904 Pathogenic MSH2 P43246 D231Q 231 D Q 0.246 Neutral MSH2 P43246 D231R 231 D R 0.906 Pathogenic MSH2 P43246 D231S 231 D S 0.312 Neutral MSH2 P43246 D231T 231 D T 0.464 Neutral MSH2 P43246 D231V 231 D V 0.986 Pathogenic MSH2 P43246 D231W 231 D W 0.986 Pathogenic MSH2 P43246 D231Y 231 D Y 0.98 Pathogenic MSH2 P43246 F232A 232 F A 0.242 Neutral MSH2 P43246 F232C 232 F C 0.73 Pathogenic MSH2 P43246 F232D 232 F D 0.816 Pathogenic MSH2 P43246 F232E 232 F E 0.86 Pathogenic MSH2 P43246 F232G 232 F G 0.514 Pathogenic MSH2 P43246 F232H 232 F H 0.76 Pathogenic MSH2 P43246 F232I 232 F I 0.672 Pathogenic MSH2 P43246 F232K 232 F K 0.838 Pathogenic MSH2 P43246 F232L 232 F L 0.696 Pathogenic MSH2 P43246 F232M 232 F M 0.392 Neutral MSH2 P43246 F232N 232 F N 0.764 Pathogenic MSH2 P43246 F232P 232 F P 0.954 Pathogenic MSH2 P43246 F232Q 232 F Q 0.776 Pathogenic MSH2 P43246 F232R 232 F R 0.908 Pathogenic MSH2 P43246 F232S 232 F S 0.886 Pathogenic MSH2 P43246 F232T 232 F T 0.594 Pathogenic MSH2 P43246 F232V 232 F V 0.732 Pathogenic MSH2 P43246 F232W 232 F W 0.744 Pathogenic MSH2 P43246 F232Y 232 F Y 0.264 Neutral MSH2 P43246 S233A 233 S A 0.076 Neutral MSH2 P43246 S233C 233 S C 0.408 Neutral MSH2 P43246 S233D 233 S D 0.102 Neutral MSH2 P43246 S233E 233 S E 0.542 Pathogenic MSH2 P43246 S233F 233 S F 0.768 Pathogenic MSH2 P43246 S233G 233 S G 0.034 Neutral MSH2 P43246 S233H 233 S H 0.574 Pathogenic MSH2 P43246 S233I 233 S I 0.526 Pathogenic MSH2 P43246 S233K 233 S K 0.43 Neutral MSH2 P43246 S233L 233 S L 0.378 Neutral MSH2 P43246 S233M 233 S M 0.888 Pathogenic MSH2 P43246 S233N 233 S N 0.042 Neutral MSH2 P43246 S233P 233 S P 0.558 Pathogenic MSH2 P43246 S233Q 233 S Q 0.434 Neutral MSH2 P43246 S233R 233 S R 0.476 Neutral MSH2 P43246 S233T 233 S T 0.052 Neutral MSH2 P43246 S233V 233 S V 0.458 Neutral MSH2 P43246 S233W 233 S W 0.928 Pathogenic MSH2 P43246 S233Y 233 S Y 0.902 Pathogenic MSH2 P43246 T234A 234 T A 0.05 Neutral MSH2 P43246 T234C 234 T C 0.372 Neutral MSH2 P43246 T234D 234 T D 0.108 Neutral MSH2 P43246 T234E 234 T E 0.214 Neutral MSH2 P43246 T234F 234 T F 0.688 Pathogenic MSH2 P43246 T234G 234 T G 0.03 Neutral MSH2 P43246 T234H 234 T H 0.45 Neutral MSH2 P43246 T234I 234 T I 0.112 Neutral MSH2 P43246 T234K 234 T K 0.084 Neutral MSH2 P43246 T234L 234 T L 0.162 Neutral MSH2 P43246 T234M 234 T M 0.14 Neutral MSH2 P43246 T234N 234 T N 0.008 Neutral MSH2 P43246 T234P 234 T P 0.184 Neutral MSH2 P43246 T234Q 234 T Q 0.3 Neutral MSH2 P43246 T234R 234 T R 0.648 Pathogenic MSH2 P43246 T234S 234 T S 0.012 Neutral MSH2 P43246 T234V 234 T V 0.066 Neutral MSH2 P43246 T234W 234 T W 0.916 Pathogenic MSH2 P43246 T234Y 234 T Y 0.91 Pathogenic MSH2 P43246 K235A 235 K A 0.532 Pathogenic MSH2 P43246 K235C 235 K C 0.44 Neutral MSH2 P43246 K235D 235 K D 0.07 Neutral MSH2 P43246 K235E 235 K E 0.086 Neutral MSH2 P43246 K235F 235 K F 0.946 Pathogenic MSH2 P43246 K235G 235 K G 0.206 Neutral MSH2 P43246 K235H 235 K H 0.24 Neutral MSH2 P43246 K235I 235 K I 0.984 Pathogenic MSH2 P43246 K235L 235 K L 0.68 Pathogenic MSH2 P43246 K235M 235 K M 0.894 Pathogenic MSH2 P43246 K235N 235 K N 0.096 Neutral MSH2 P43246 K235P 235 K P 0.908 Pathogenic MSH2 P43246 K235Q 235 K Q 0.098 Neutral MSH2 P43246 K235R 235 K R 0.12 Neutral MSH2 P43246 K235S 235 K S 0.182 Neutral MSH2 P43246 K235T 235 K T 0.158 Neutral MSH2 P43246 K235V 235 K V 0.516 Pathogenic MSH2 P43246 K235W 235 K W 0.988 Pathogenic MSH2 P43246 K235Y 235 K Y 0.978 Pathogenic MSH2 P43246 D236A 236 D A 0.718 Pathogenic MSH2 P43246 D236C 236 D C 0.92 Pathogenic MSH2 P43246 D236E 236 D E 0.284 Neutral MSH2 P43246 D236F 236 D F 0.984 Pathogenic MSH2 P43246 D236G 236 D G 0.238 Neutral MSH2 P43246 D236H 236 D H 0.628 Pathogenic MSH2 P43246 D236I 236 D I 0.97 Pathogenic MSH2 P43246 D236K 236 D K 0.984 Pathogenic MSH2 P43246 D236L 236 D L 0.98 Pathogenic MSH2 P43246 D236M 236 D M 0.962 Pathogenic MSH2 P43246 D236N 236 D N 0.12 Neutral MSH2 P43246 D236P 236 D P 0.914 Pathogenic MSH2 P43246 D236Q 236 D Q 0.768 Pathogenic MSH2 P43246 D236R 236 D R 0.916 Pathogenic MSH2 P43246 D236S 236 D S 0.112 Neutral MSH2 P43246 D236T 236 D T 0.462 Neutral MSH2 P43246 D236V 236 D V 0.992 Pathogenic MSH2 P43246 D236W 236 D W 0.986 Pathogenic MSH2 P43246 D236Y 236 D Y 0.98 Pathogenic MSH2 P43246 I237A 237 I A 0.108 Neutral MSH2 P43246 I237C 237 I C 0.632 Pathogenic MSH2 P43246 I237D 237 I D 0.774 Pathogenic MSH2 P43246 I237E 237 I E 0.208 Neutral MSH2 P43246 I237F 237 I F 0.948 Pathogenic MSH2 P43246 I237G 237 I G 0.818 Pathogenic MSH2 P43246 I237H 237 I H 0.85 Pathogenic MSH2 P43246 I237K 237 I K 0.86 Pathogenic MSH2 P43246 I237L 237 I L 0.092 Neutral MSH2 P43246 I237M 237 I M 0.21 Neutral MSH2 P43246 I237N 237 I N 0.258 Neutral MSH2 P43246 I237P 237 I P 0.936 Pathogenic MSH2 P43246 I237Q 237 I Q 0.808 Pathogenic MSH2 P43246 I237R 237 I R 0.884 Pathogenic MSH2 P43246 I237S 237 I S 0.158 Neutral MSH2 P43246 I237T 237 I T 0.102 Neutral MSH2 P43246 I237V 237 I V 0.106 Neutral MSH2 P43246 I237W 237 I W 0.972 Pathogenic MSH2 P43246 I237Y 237 I Y 0.966 Pathogenic MSH2 P43246 Y238A 238 Y A 0.124 Neutral MSH2 P43246 Y238C 238 Y C 0.182 Neutral MSH2 P43246 Y238D 238 Y D 0.096 Neutral MSH2 P43246 Y238E 238 Y E 0.104 Neutral MSH2 P43246 Y238F 238 Y F 0.35 Neutral MSH2 P43246 Y238G 238 Y G 0.242 Neutral MSH2 P43246 Y238H 238 Y H 0.126 Neutral MSH2 P43246 Y238I 238 Y I 0.072 Neutral MSH2 P43246 Y238K 238 Y K 0.074 Neutral MSH2 P43246 Y238L 238 Y L 0.054 Neutral MSH2 P43246 Y238M 238 Y M 0.296 Neutral MSH2 P43246 Y238N 238 Y N 0.284 Neutral MSH2 P43246 Y238P 238 Y P 0.378 Neutral MSH2 P43246 Y238Q 238 Y Q 0.096 Neutral MSH2 P43246 Y238R 238 Y R 0.558 Pathogenic MSH2 P43246 Y238S 238 Y S 0.274 Neutral MSH2 P43246 Y238T 238 Y T 0.298 Neutral MSH2 P43246 Y238V 238 Y V 0.042 Neutral MSH2 P43246 Y238W 238 Y W 0.464 Neutral MSH2 P43246 Q239A 239 Q A 0.422 Neutral MSH2 P43246 Q239C 239 Q C 0.714 Pathogenic MSH2 P43246 Q239D 239 Q D 0.178 Neutral MSH2 P43246 Q239E 239 Q E 0.26 Neutral MSH2 P43246 Q239F 239 Q F 0.932 Pathogenic MSH2 P43246 Q239G 239 Q G 0.304 Neutral MSH2 P43246 Q239H 239 Q H 0.992 Pathogenic MSH2 P43246 Q239I 239 Q I 0.954 Pathogenic MSH2 P43246 Q239K 239 Q K 0.978 Pathogenic MSH2 P43246 Q239L 239 Q L 0.552 Pathogenic MSH2 P43246 Q239M 239 Q M 0.49 Neutral MSH2 P43246 Q239N 239 Q N 0.33 Neutral MSH2 P43246 Q239P 239 Q P 0.724 Pathogenic MSH2 P43246 Q239R 239 Q R 0.608 Pathogenic MSH2 P43246 Q239S 239 Q S 0.232 Neutral MSH2 P43246 Q239T 239 Q T 0.422 Neutral MSH2 P43246 Q239V 239 Q V 0.44 Neutral MSH2 P43246 Q239W 239 Q W 0.964 Pathogenic MSH2 P43246 Q239Y 239 Q Y 0.952 Pathogenic MSH2 P43246 Q24A 24 Q A 0.056 Neutral MSH2 P43246 Q24C 24 Q C 0.134 Neutral MSH2 P43246 Q24D 24 Q D 0.004 Neutral MSH2 P43246 Q24E 24 Q E 0.012 Neutral MSH2 P43246 Q24F 24 Q F 0.264 Neutral MSH2 P43246 Q24G 24 Q G 0.24 Neutral MSH2 P43246 Q24H 24 Q H 0.038 Neutral MSH2 P43246 Q24I 24 Q I 0.382 Neutral MSH2 P43246 Q24K 24 Q K 0.028 Neutral MSH2 P43246 Q24L 24 Q L 0.138 Neutral MSH2 P43246 Q24M 24 Q M 0.338 Neutral MSH2 P43246 Q24N 24 Q N 0.026 Neutral MSH2 P43246 Q24P 24 Q P 0.49 Neutral MSH2 P43246 Q24R 24 Q R 0.016 Neutral MSH2 P43246 Q24S 24 Q S 0.052 Neutral MSH2 P43246 Q24T 24 Q T 0.008 Neutral MSH2 P43246 Q24V 24 Q V 0.192 Neutral MSH2 P43246 Q24W 24 Q W 0.724 Pathogenic MSH2 P43246 Q24Y 24 Q Y 0.526 Pathogenic MSH2 P43246 D240A 240 D A 0.79 Pathogenic MSH2 P43246 D240C 240 D C 0.878 Pathogenic MSH2 P43246 D240E 240 D E 0.57 Pathogenic MSH2 P43246 D240F 240 D F 0.98 Pathogenic MSH2 P43246 D240G 240 D G 0.932 Pathogenic MSH2 P43246 D240H 240 D H 0.654 Pathogenic MSH2 P43246 D240I 240 D I 0.974 Pathogenic MSH2 P43246 D240K 240 D K 0.918 Pathogenic MSH2 P43246 D240L 240 D L 0.656 Pathogenic MSH2 P43246 D240M 240 D M 0.956 Pathogenic MSH2 P43246 D240N 240 D N 0.5 Pathogenic MSH2 P43246 D240P 240 D P 0.9 Pathogenic MSH2 P43246 D240Q 240 D Q 0.612 Pathogenic MSH2 P43246 D240R 240 D R 0.958 Pathogenic MSH2 P43246 D240S 240 D S 0.356 Neutral MSH2 P43246 D240T 240 D T 0.552 Pathogenic MSH2 P43246 D240V 240 D V 0.996 Pathogenic MSH2 P43246 D240W 240 D W 0.98 Pathogenic MSH2 P43246 D240Y 240 D Y 0.972 Pathogenic MSH2 P43246 L241A 241 L A 0.714 Pathogenic MSH2 P43246 L241C 241 L C 0.822 Pathogenic MSH2 P43246 L241D 241 L D 0.91 Pathogenic MSH2 P43246 L241E 241 L E 0.896 Pathogenic MSH2 P43246 L241F 241 L F 0.872 Pathogenic MSH2 P43246 L241G 241 L G 0.864 Pathogenic MSH2 P43246 L241H 241 L H 0.91 Pathogenic MSH2 P43246 L241I 241 L I 0.47 Neutral MSH2 P43246 L241K 241 L K 0.728 Pathogenic MSH2 P43246 L241M 241 L M 0.35 Neutral MSH2 P43246 L241N 241 L N 0.82 Pathogenic MSH2 P43246 L241P 241 L P 0.994 Pathogenic MSH2 P43246 L241Q 241 L Q 0.776 Pathogenic MSH2 P43246 L241R 241 L R 0.986 Pathogenic MSH2 P43246 L241S 241 L S 0.706 Pathogenic MSH2 P43246 L241T 241 L T 0.626 Pathogenic MSH2 P43246 L241V 241 L V 0.272 Neutral MSH2 P43246 L241W 241 L W 0.878 Pathogenic MSH2 P43246 L241Y 241 L Y 0.89 Pathogenic MSH2 P43246 N242A 242 N A 0.074 Neutral MSH2 P43246 N242C 242 N C 0.576 Pathogenic MSH2 P43246 N242D 242 N D 0.058 Neutral MSH2 P43246 N242E 242 N E 0.596 Pathogenic MSH2 P43246 N242F 242 N F 0.906 Pathogenic MSH2 P43246 N242G 242 N G 0.074 Neutral MSH2 P43246 N242H 242 N H 0.744 Pathogenic MSH2 P43246 N242I 242 N I 0.56 Pathogenic MSH2 P43246 N242K 242 N K 0.126 Neutral MSH2 P43246 N242L 242 N L 0.828 Pathogenic MSH2 P43246 N242M 242 N M 0.248 Neutral MSH2 P43246 N242P 242 N P 0.242 Neutral MSH2 P43246 N242Q 242 N Q 0.308 Neutral MSH2 P43246 N242R 242 N R 0.478 Neutral MSH2 P43246 N242S 242 N S 0.048 Neutral MSH2 P43246 N242T 242 N T 0.032 Neutral MSH2 P43246 N242V 242 N V 0.118 Neutral MSH2 P43246 N242W 242 N W 0.954 Pathogenic MSH2 P43246 N242Y 242 N Y 0.946 Pathogenic MSH2 P43246 R243A 243 R A 0.574 Pathogenic MSH2 P43246 R243C 243 R C 0.394 Neutral MSH2 P43246 R243D 243 R D 0.694 Pathogenic MSH2 P43246 R243E 243 R E 0.78 Pathogenic MSH2 P43246 R243F 243 R F 0.964 Pathogenic MSH2 P43246 R243G 243 R G 0.43 Neutral MSH2 P43246 R243H 243 R H 0.182 Neutral MSH2 P43246 R243I 243 R I 0.974 Pathogenic MSH2 P43246 R243K 243 R K 0.288 Neutral MSH2 P43246 R243L 243 R L 0.378 Neutral MSH2 P43246 R243M 243 R M 0.762 Pathogenic MSH2 P43246 R243N 243 R N 0.254 Neutral MSH2 P43246 R243P 243 R P 0.984 Pathogenic MSH2 P43246 R243Q 243 R Q 0.236 Neutral MSH2 P43246 R243S 243 R S 0.934 Pathogenic MSH2 P43246 R243T 243 R T 0.188 Neutral MSH2 P43246 R243V 243 R V 0.442 Neutral MSH2 P43246 R243W 243 R W 0.946 Pathogenic MSH2 P43246 R243Y 243 R Y 0.95 Pathogenic MSH2 P43246 L244A 244 L A 0.714 Pathogenic MSH2 P43246 L244C 244 L C 0.822 Pathogenic MSH2 P43246 L244D 244 L D 0.91 Pathogenic MSH2 P43246 L244E 244 L E 0.896 Pathogenic MSH2 P43246 L244F 244 L F 0.878 Pathogenic MSH2 P43246 L244G 244 L G 0.864 Pathogenic MSH2 P43246 L244H 244 L H 0.91 Pathogenic MSH2 P43246 L244I 244 L I 0.432 Neutral MSH2 P43246 L244K 244 L K 0.728 Pathogenic MSH2 P43246 L244M 244 L M 0.61 Pathogenic MSH2 P43246 L244N 244 L N 0.82 Pathogenic MSH2 P43246 L244P 244 L P 0.994 Pathogenic MSH2 P43246 L244Q 244 L Q 0.776 Pathogenic MSH2 P43246 L244R 244 L R 0.986 Pathogenic MSH2 P43246 L244S 244 L S 0.706 Pathogenic MSH2 P43246 L244T 244 L T 0.628 Pathogenic MSH2 P43246 L244V 244 L V 0.34 Neutral MSH2 P43246 L244W 244 L W 0.88 Pathogenic MSH2 P43246 L244Y 244 L Y 0.89 Pathogenic MSH2 P43246 L245A 245 L A 0.698 Pathogenic MSH2 P43246 L245C 245 L C 0.26 Neutral MSH2 P43246 L245D 245 L D 0.896 Pathogenic MSH2 P43246 L245E 245 L E 0.876 Pathogenic MSH2 P43246 L245F 245 L F 0.956 Pathogenic MSH2 P43246 L245G 245 L G 0.814 Pathogenic MSH2 P43246 L245H 245 L H 0.906 Pathogenic MSH2 P43246 L245I 245 L I 0.216 Neutral MSH2 P43246 L245K 245 L K 0.75 Pathogenic MSH2 P43246 L245M 245 L M 0.718 Pathogenic MSH2 P43246 L245N 245 L N 0.766 Pathogenic MSH2 P43246 L245P 245 L P 0.992 Pathogenic MSH2 P43246 L245Q 245 L Q 0.734 Pathogenic MSH2 P43246 L245R 245 L R 0.984 Pathogenic MSH2 P43246 L245S 245 L S 0.644 Pathogenic MSH2 P43246 L245T 245 L T 0.284 Neutral MSH2 P43246 L245V 245 L V 0.044 Neutral MSH2 P43246 L245W 245 L W 0.928 Pathogenic MSH2 P43246 L245Y 245 L Y 0.894 Pathogenic MSH2 P43246 K246A 246 K A 0.156 Neutral MSH2 P43246 K246C 246 K C 0.22 Neutral MSH2 P43246 K246D 246 K D 0.136 Neutral MSH2 P43246 K246E 246 K E 0.024 Neutral MSH2 P43246 K246F 246 K F 0.854 Pathogenic MSH2 P43246 K246G 246 K G 0.288 Neutral MSH2 P43246 K246H 246 K H 0.066 Neutral MSH2 P43246 K246I 246 K I 0.898 Pathogenic MSH2 P43246 K246L 246 K L 0.674 Pathogenic MSH2 P43246 K246M 246 K M 0.652 Pathogenic MSH2 P43246 K246N 246 K N 0.026 Neutral MSH2 P43246 K246P 246 K P 0.354 Neutral MSH2 P43246 K246Q 246 K Q 0.086 Neutral MSH2 P43246 K246R 246 K R 0.044 Neutral MSH2 P43246 K246S 246 K S 0.026 Neutral MSH2 P43246 K246T 246 K T 0.028 Neutral MSH2 P43246 K246V 246 K V 0.362 Neutral MSH2 P43246 K246W 246 K W 0.97 Pathogenic MSH2 P43246 K246Y 246 K Y 0.86 Pathogenic MSH2 P43246 G247A 247 G A 0.006 Neutral MSH2 P43246 G247C 247 G C 0.34 Neutral MSH2 P43246 G247D 247 G D 0.224 Neutral MSH2 P43246 G247E 247 G E 0.57 Pathogenic MSH2 P43246 G247F 247 G F 0.492 Neutral MSH2 P43246 G247H 247 G H 0.708 Pathogenic MSH2 P43246 G247I 247 G I 0.698 Pathogenic MSH2 P43246 G247K 247 G K 0.634 Pathogenic MSH2 P43246 G247L 247 G L 0.432 Neutral MSH2 P43246 G247M 247 G M 0.698 Pathogenic MSH2 P43246 G247N 247 G N 0.332 Neutral MSH2 P43246 G247P 247 G P 0.456 Neutral MSH2 P43246 G247Q 247 G Q 0.364 Neutral MSH2 P43246 G247R 247 G R 0.76 Pathogenic MSH2 P43246 G247S 247 G S 0.022 Neutral MSH2 P43246 G247T 247 G T 0.36 Neutral MSH2 P43246 G247V 247 G V 0.416 Neutral MSH2 P43246 G247W 247 G W 0.752 Pathogenic MSH2 P43246 G247Y 247 G Y 0.746 Pathogenic MSH2 P43246 K248A 248 K A 0.032 Neutral MSH2 P43246 K248C 248 K C 0.058 Neutral MSH2 P43246 K248D 248 K D 0.002 Neutral MSH2 P43246 K248E 248 K E 0.004 Neutral MSH2 P43246 K248F 248 K F 0.364 Neutral MSH2 P43246 K248G 248 K G 0.048 Neutral MSH2 P43246 K248H 248 K H 0.084 Neutral MSH2 P43246 K248I 248 K I 0.396 Neutral MSH2 P43246 K248L 248 K L 0.38 Neutral MSH2 P43246 K248M 248 K M 0.19 Neutral MSH2 P43246 K248N 248 K N 0.056 Neutral MSH2 P43246 K248P 248 K P 0.022 Neutral MSH2 P43246 K248Q 248 K Q 0.13 Neutral MSH2 P43246 K248R 248 K R 0.006 Neutral MSH2 P43246 K248S 248 K S 0.014 Neutral MSH2 P43246 K248T 248 K T 0.014 Neutral MSH2 P43246 K248V 248 K V 0.298 Neutral MSH2 P43246 K248W 248 K W 0.678 Pathogenic MSH2 P43246 K248Y 248 K Y 0.582 Pathogenic MSH2 P43246 K249A 249 K A 0.056 Neutral MSH2 P43246 K249C 249 K C 0.028 Neutral MSH2 P43246 K249D 249 K D 0.066 Neutral MSH2 P43246 K249E 249 K E 0.072 Neutral MSH2 P43246 K249F 249 K F 0.234 Neutral MSH2 P43246 K249G 249 K G 0.134 Neutral MSH2 P43246 K249H 249 K H 0.02 Neutral MSH2 P43246 K249I 249 K I 0.248 Neutral MSH2 P43246 K249L 249 K L 0.042 Neutral MSH2 P43246 K249M 249 K M 0.112 Neutral MSH2 P43246 K249N 249 K N 0.006 Neutral MSH2 P43246 K249P 249 K P 0.254 Neutral MSH2 P43246 K249Q 249 K Q 0.09 Neutral MSH2 P43246 K249R 249 K R 0.002 Neutral MSH2 P43246 K249S 249 K S 0.014 Neutral MSH2 P43246 K249T 249 K T 0.028 Neutral MSH2 P43246 K249V 249 K V 0.126 Neutral MSH2 P43246 K249W 249 K W 0.482 Neutral MSH2 P43246 K249Y 249 K Y 0.266 Neutral MSH2 P43246 G25A 25 G A 0.086 Neutral MSH2 P43246 G25C 25 G C 0.736 Pathogenic MSH2 P43246 G25D 25 G D 0.654 Pathogenic MSH2 P43246 G25E 25 G E 0.912 Pathogenic MSH2 P43246 G25F 25 G F 0.96 Pathogenic MSH2 P43246 G25H 25 G H 0.928 Pathogenic MSH2 P43246 G25I 25 G I 0.93 Pathogenic MSH2 P43246 G25K 25 G K 0.578 Pathogenic MSH2 P43246 G25L 25 G L 0.934 Pathogenic MSH2 P43246 G25M 25 G M 0.954 Pathogenic MSH2 P43246 G25N 25 G N 0.442 Neutral MSH2 P43246 G25P 25 G P 0.9 Pathogenic MSH2 P43246 G25Q 25 G Q 0.524 Pathogenic MSH2 P43246 G25R 25 G R 0.59 Pathogenic MSH2 P43246 G25S 25 G S 0.116 Neutral MSH2 P43246 G25T 25 G T 0.548 Pathogenic MSH2 P43246 G25V 25 G V 0.94 Pathogenic MSH2 P43246 G25W 25 G W 0.95 Pathogenic MSH2 P43246 G25Y 25 G Y 0.938 Pathogenic MSH2 P43246 G250A 250 G A 0.12 Neutral MSH2 P43246 G250C 250 G C 0.306 Neutral MSH2 P43246 G250D 250 G D 0.388 Neutral MSH2 P43246 G250E 250 G E 0.284 Neutral MSH2 P43246 G250F 250 G F 0.68 Pathogenic MSH2 P43246 G250H 250 G H 0.622 Pathogenic MSH2 P43246 G250I 250 G I 0.608 Pathogenic MSH2 P43246 G250K 250 G K 0.428 Neutral MSH2 P43246 G250L 250 G L 0.436 Neutral MSH2 P43246 G250M 250 G M 0.614 Pathogenic MSH2 P43246 G250N 250 G N 0.388 Neutral MSH2 P43246 G250P 250 G P 0.6 Pathogenic MSH2 P43246 G250Q 250 G Q 0.412 Neutral MSH2 P43246 G250R 250 G R 0.666 Pathogenic MSH2 P43246 G250S 250 G S 0.024 Neutral MSH2 P43246 G250T 250 G T 0.344 Neutral MSH2 P43246 G250V 250 G V 0.458 Neutral MSH2 P43246 G250W 250 G W 0.678 Pathogenic MSH2 P43246 G250Y 250 G Y 0.668 Pathogenic MSH2 P43246 E251A 251 E A 0.078 Neutral MSH2 P43246 E251C 251 E C 0.118 Neutral MSH2 P43246 E251D 251 E D 0.002 Neutral MSH2 P43246 E251F 251 E F 0.422 Neutral MSH2 P43246 E251G 251 E G 0.024 Neutral MSH2 P43246 E251H 251 E H 0.244 Neutral MSH2 P43246 E251I 251 E I 0.492 Neutral MSH2 P43246 E251K 251 E K 0.008 Neutral MSH2 P43246 E251L 251 E L 0.448 Neutral MSH2 P43246 E251M 251 E M 0.278 Neutral MSH2 P43246 E251N 251 E N 0.086 Neutral MSH2 P43246 E251P 251 E P 0.466 Neutral MSH2 P43246 E251Q 251 E Q 0 Neutral MSH2 P43246 E251R 251 E R 0.118 Neutral MSH2 P43246 E251S 251 E S 0.074 Neutral MSH2 P43246 E251T 251 E T 0.25 Neutral MSH2 P43246 E251V 251 E V 0.046 Neutral MSH2 P43246 E251W 251 E W 0.694 Pathogenic MSH2 P43246 E251Y 251 E Y 0.58 Pathogenic MSH2 P43246 Q252A 252 Q A 0.05 Neutral MSH2 P43246 Q252C 252 Q C 0.106 Neutral MSH2 P43246 Q252D 252 Q D 0 Neutral MSH2 P43246 Q252E 252 Q E 0.01 Neutral MSH2 P43246 Q252F 252 Q F 0.42 Neutral MSH2 P43246 Q252G 252 Q G 0.074 Neutral MSH2 P43246 Q252H 252 Q H 0.18 Neutral MSH2 P43246 Q252I 252 Q I 0.44 Neutral MSH2 P43246 Q252K 252 Q K 0.024 Neutral MSH2 P43246 Q252L 252 Q L 0.482 Neutral MSH2 P43246 Q252M 252 Q M 0.348 Neutral MSH2 P43246 Q252N 252 Q N 0.106 Neutral MSH2 P43246 Q252P 252 Q P 0.532 Pathogenic MSH2 P43246 Q252R 252 Q R 0.144 Neutral MSH2 P43246 Q252S 252 Q S 0.042 Neutral MSH2 P43246 Q252T 252 Q T 0.004 Neutral MSH2 P43246 Q252V 252 Q V 0.426 Neutral MSH2 P43246 Q252W 252 Q W 0.678 Pathogenic MSH2 P43246 Q252Y 252 Q Y 0.606 Pathogenic MSH2 P43246 M253A 253 M A 0.046 Neutral MSH2 P43246 M253C 253 M C 0.042 Neutral MSH2 P43246 M253D 253 M D 0.14 Neutral MSH2 P43246 M253E 253 M E 0.008 Neutral MSH2 P43246 M253F 253 M F 0.218 Neutral MSH2 P43246 M253G 253 M G 0.056 Neutral MSH2 P43246 M253H 253 M H 0.026 Neutral MSH2 P43246 M253I 253 M I 0.004 Neutral MSH2 P43246 M253K 253 M K 0.018 Neutral MSH2 P43246 M253L 253 M L 0.004 Neutral MSH2 P43246 M253N 253 M N 0.138 Neutral MSH2 P43246 M253P 253 M P 0.034 Neutral MSH2 P43246 M253Q 253 M Q 0.002 Neutral MSH2 P43246 M253R 253 M R 0.084 Neutral MSH2 P43246 M253S 253 M S 0.012 Neutral MSH2 P43246 M253T 253 M T 0.008 Neutral MSH2 P43246 M253V 253 M V 0.016 Neutral MSH2 P43246 M253W 253 M W 0.422 Neutral MSH2 P43246 M253Y 253 M Y 0.348 Neutral MSH2 P43246 N254A 254 N A 0.006 Neutral MSH2 P43246 N254C 254 N C 0.258 Neutral MSH2 P43246 N254D 254 N D 0.01 Neutral MSH2 P43246 N254E 254 N E 0.228 Neutral MSH2 P43246 N254F 254 N F 0.67 Pathogenic MSH2 P43246 N254G 254 N G 0.222 Neutral MSH2 P43246 N254H 254 N H 0.362 Neutral MSH2 P43246 N254I 254 N I 0.504 Pathogenic MSH2 P43246 N254K 254 N K 0.04 Neutral MSH2 P43246 N254L 254 N L 0.434 Neutral MSH2 P43246 N254M 254 N M 0.39 Neutral MSH2 P43246 N254P 254 N P 0.282 Neutral MSH2 P43246 N254Q 254 N Q 0.016 Neutral MSH2 P43246 N254R 254 N R 0.356 Neutral MSH2 P43246 N254S 254 N S 0.004 Neutral MSH2 P43246 N254T 254 N T 0.008 Neutral MSH2 P43246 N254V 254 N V 0.184 Neutral MSH2 P43246 N254W 254 N W 0.712 Pathogenic MSH2 P43246 N254Y 254 N Y 0.666 Pathogenic MSH2 P43246 S255A 255 S A 0.074 Neutral MSH2 P43246 S255C 255 S C 0.154 Neutral MSH2 P43246 S255D 255 S D 0.314 Neutral MSH2 P43246 S255E 255 S E 0.666 Pathogenic MSH2 P43246 S255F 255 S F 0.78 Pathogenic MSH2 P43246 S255G 255 S G 0.036 Neutral MSH2 P43246 S255H 255 S H 0.492 Neutral MSH2 P43246 S255I 255 S I 0.35 Neutral MSH2 P43246 S255K 255 S K 0.44 Neutral MSH2 P43246 S255L 255 S L 0.174 Neutral MSH2 P43246 S255M 255 S M 0.892 Pathogenic MSH2 P43246 S255N 255 S N 0.106 Neutral MSH2 P43246 S255P 255 S P 0.248 Neutral MSH2 P43246 S255Q 255 S Q 0.618 Pathogenic MSH2 P43246 S255R 255 S R 0.754 Pathogenic MSH2 P43246 S255T 255 S T 0.056 Neutral MSH2 P43246 S255V 255 S V 0.088 Neutral MSH2 P43246 S255W 255 S W 0.932 Pathogenic MSH2 P43246 S255Y 255 S Y 0.906 Pathogenic MSH2 P43246 A256C 256 A C 0.572 Pathogenic MSH2 P43246 A256D 256 A D 0.608 Pathogenic MSH2 P43246 A256E 256 A E 0.748 Pathogenic MSH2 P43246 A256F 256 A F 0.89 Pathogenic MSH2 P43246 A256G 256 A G 0.044 Neutral MSH2 P43246 A256H 256 A H 0.608 Pathogenic MSH2 P43246 A256I 256 A I 0.542 Pathogenic MSH2 P43246 A256K 256 A K 0.5 Pathogenic MSH2 P43246 A256L 256 A L 0.524 Pathogenic MSH2 P43246 A256M 256 A M 0.608 Pathogenic MSH2 P43246 A256N 256 A N 0.522 Pathogenic MSH2 P43246 A256P 256 A P 0.712 Pathogenic MSH2 P43246 A256Q 256 A Q 0.464 Neutral MSH2 P43246 A256R 256 A R 0.536 Pathogenic MSH2 P43246 A256S 256 A S 0.042 Neutral MSH2 P43246 A256T 256 A T 0.052 Neutral MSH2 P43246 A256V 256 A V 0.106 Neutral MSH2 P43246 A256W 256 A W 0.886 Pathogenic MSH2 P43246 A256Y 256 A Y 0.882 Pathogenic MSH2 P43246 V257A 257 V A 0.028 Neutral MSH2 P43246 V257C 257 V C 0.322 Neutral MSH2 P43246 V257D 257 V D 0.072 Neutral MSH2 P43246 V257E 257 V E 0.11 Neutral MSH2 P43246 V257F 257 V F 0.56 Pathogenic MSH2 P43246 V257G 257 V G 0.102 Neutral MSH2 P43246 V257H 257 V H 0.358 Neutral MSH2 P43246 V257I 257 V I 0.03 Neutral MSH2 P43246 V257K 257 V K 0.38 Neutral MSH2 P43246 V257L 257 V L 0.022 Neutral MSH2 P43246 V257M 257 V M 0.29 Neutral MSH2 P43246 V257N 257 V N 0.094 Neutral MSH2 P43246 V257P 257 V P 0.692 Pathogenic MSH2 P43246 V257Q 257 V Q 0.17 Neutral MSH2 P43246 V257R 257 V R 0.766 Pathogenic MSH2 P43246 V257S 257 V S 0.05 Neutral MSH2 P43246 V257T 257 V T 0.03 Neutral MSH2 P43246 V257W 257 V W 0.724 Pathogenic MSH2 P43246 V257Y 257 V Y 0.7 Pathogenic MSH2 P43246 L258A 258 L A 0.568 Pathogenic MSH2 P43246 L258C 258 L C 0.694 Pathogenic MSH2 P43246 L258D 258 L D 0.2 Neutral MSH2 P43246 L258E 258 L E 0.872 Pathogenic MSH2 P43246 L258F 258 L F 0.5 Pathogenic MSH2 P43246 L258G 258 L G 0.788 Pathogenic MSH2 P43246 L258H 258 L H 0.822 Pathogenic MSH2 P43246 L258I 258 L I 0.162 Neutral MSH2 P43246 L258K 258 L K 0.742 Pathogenic MSH2 P43246 L258M 258 L M 0.268 Neutral MSH2 P43246 L258N 258 L N 0.194 Neutral MSH2 P43246 L258P 258 L P 0.988 Pathogenic MSH2 P43246 L258Q 258 L Q 0.624 Pathogenic MSH2 P43246 L258R 258 L R 0.568 Pathogenic MSH2 P43246 L258S 258 L S 0.132 Neutral MSH2 P43246 L258T 258 L T 0.58 Pathogenic MSH2 P43246 L258V 258 L V 0.084 Neutral MSH2 P43246 L258W 258 L W 0.94 Pathogenic MSH2 P43246 L258Y 258 L Y 0.746 Pathogenic MSH2 P43246 P259A 259 P A 0.156 Neutral MSH2 P43246 P259C 259 P C 0.922 Pathogenic MSH2 P43246 P259D 259 P D 0.778 Pathogenic MSH2 P43246 P259E 259 P E 0.354 Neutral MSH2 P43246 P259F 259 P F 0.988 Pathogenic MSH2 P43246 P259G 259 P G 0.52 Pathogenic MSH2 P43246 P259H 259 P H 0.584 Pathogenic MSH2 P43246 P259I 259 P I 0.332 Neutral MSH2 P43246 P259K 259 P K 0.258 Neutral MSH2 P43246 P259L 259 P L 0.952 Pathogenic MSH2 P43246 P259M 259 P M 0.97 Pathogenic MSH2 P43246 P259N 259 P N 0.314 Neutral MSH2 P43246 P259Q 259 P Q 0.28 Neutral MSH2 P43246 P259R 259 P R 0.564 Pathogenic MSH2 P43246 P259S 259 P S 0.094 Neutral MSH2 P43246 P259T 259 P T 0.398 Neutral MSH2 P43246 P259V 259 P V 0.126 Neutral MSH2 P43246 P259W 259 P W 0.912 Pathogenic MSH2 P43246 P259Y 259 P Y 0.896 Pathogenic MSH2 P43246 M26A 26 M A 0.558 Pathogenic MSH2 P43246 M26C 26 M C 0.472 Neutral MSH2 P43246 M26D 26 M D 0.87 Pathogenic MSH2 P43246 M26E 26 M E 0.732 Pathogenic MSH2 P43246 M26F 26 M F 0.87 Pathogenic MSH2 P43246 M26G 26 M G 0.294 Neutral MSH2 P43246 M26H 26 M H 0.828 Pathogenic MSH2 P43246 M26I 26 M I 0.3 Neutral MSH2 P43246 M26K 26 M K 0.9 Pathogenic MSH2 P43246 M26L 26 M L 0.17 Neutral MSH2 P43246 M26N 26 M N 0.9 Pathogenic MSH2 P43246 M26P 26 M P 0.924 Pathogenic MSH2 P43246 M26Q 26 M Q 0.668 Pathogenic MSH2 P43246 M26R 26 M R 0.962 Pathogenic MSH2 P43246 M26S 26 M S 0.848 Pathogenic MSH2 P43246 M26T 26 M T 0.368 Neutral MSH2 P43246 M26V 26 M V 0.656 Pathogenic MSH2 P43246 M26W 26 M W 0.994 Pathogenic MSH2 P43246 M26Y 26 M Y 0.974 Pathogenic MSH2 P43246 E260A 260 E A 0.45 Neutral MSH2 P43246 E260C 260 E C 0.584 Pathogenic MSH2 P43246 E260D 260 E D 0.226 Neutral MSH2 P43246 E260F 260 E F 0.872 Pathogenic MSH2 P43246 E260G 260 E G 0.112 Neutral MSH2 P43246 E260H 260 E H 0.61 Pathogenic MSH2 P43246 E260I 260 E I 0.81 Pathogenic MSH2 P43246 E260K 260 E K 0.374 Neutral MSH2 P43246 E260L 260 E L 0.498 Neutral MSH2 P43246 E260M 260 E M 0.642 Pathogenic MSH2 P43246 E260N 260 E N 0.2 Neutral MSH2 P43246 E260P 260 E P 0.88 Pathogenic MSH2 P43246 E260Q 260 E Q 0.064 Neutral MSH2 P43246 E260R 260 E R 0.47 Neutral MSH2 P43246 E260S 260 E S 0.166 Neutral MSH2 P43246 E260T 260 E T 0.18 Neutral MSH2 P43246 E260V 260 E V 0.476 Neutral MSH2 P43246 E260W 260 E W 0.938 Pathogenic MSH2 P43246 E260Y 260 E Y 0.906 Pathogenic MSH2 P43246 M261A 261 M A 0.154 Neutral MSH2 P43246 M261C 261 M C 0.208 Neutral MSH2 P43246 M261D 261 M D 0.608 Pathogenic MSH2 P43246 M261E 261 M E 0.264 Neutral MSH2 P43246 M261F 261 M F 0.094 Neutral MSH2 P43246 M261G 261 M G 0.322 Neutral MSH2 P43246 M261H 261 M H 0.28 Neutral MSH2 P43246 M261I 261 M I 0.112 Neutral MSH2 P43246 M261K 261 M K 0.136 Neutral MSH2 P43246 M261L 261 M L 0.076 Neutral MSH2 P43246 M261N 261 M N 0.576 Pathogenic MSH2 P43246 M261P 261 M P 0.762 Pathogenic MSH2 P43246 M261Q 261 M Q 0.296 Neutral MSH2 P43246 M261R 261 M R 0.638 Pathogenic MSH2 P43246 M261S 261 M S 0.056 Neutral MSH2 P43246 M261T 261 M T 0.038 Neutral MSH2 P43246 M261V 261 M V 0.082 Neutral MSH2 P43246 M261W 261 M W 0.958 Pathogenic MSH2 P43246 M261Y 261 M Y 0.874 Pathogenic MSH2 P43246 E262A 262 E A 0.47 Neutral MSH2 P43246 E262C 262 E C 0.48 Neutral MSH2 P43246 E262D 262 E D 0.02 Neutral MSH2 P43246 E262F 262 E F 0.452 Neutral MSH2 P43246 E262G 262 E G 0.21 Neutral MSH2 P43246 E262H 262 E H 0.344 Neutral MSH2 P43246 E262I 262 E I 0.94 Pathogenic MSH2 P43246 E262K 262 E K 0.076 Neutral MSH2 P43246 E262L 262 E L 0.816 Pathogenic MSH2 P43246 E262M 262 E M 0.726 Pathogenic MSH2 P43246 E262N 262 E N 0.016 Neutral MSH2 P43246 E262P 262 E P 0.89 Pathogenic MSH2 P43246 E262Q 262 E Q 0.016 Neutral MSH2 P43246 E262R 262 E R 0.41 Neutral MSH2 P43246 E262S 262 E S 0.048 Neutral MSH2 P43246 E262T 262 E T 0.122 Neutral MSH2 P43246 E262V 262 E V 0.738 Pathogenic MSH2 P43246 E262W 262 E W 0.97 Pathogenic MSH2 P43246 E262Y 262 E Y 0.47 Neutral MSH2 P43246 N263A 263 N A 0.318 Neutral MSH2 P43246 N263C 263 N C 0.59 Pathogenic MSH2 P43246 N263D 263 N D 0.138 Neutral MSH2 P43246 N263E 263 N E 0.586 Pathogenic MSH2 P43246 N263F 263 N F 0.912 Pathogenic MSH2 P43246 N263G 263 N G 0.61 Pathogenic MSH2 P43246 N263H 263 N H 0.084 Neutral MSH2 P43246 N263I 263 N I 0.87 Pathogenic MSH2 P43246 N263K 263 N K 0.084 Neutral MSH2 P43246 N263L 263 N L 0.274 Neutral MSH2 P43246 N263M 263 N M 0.11 Neutral MSH2 P43246 N263P 263 N P 0.758 Pathogenic MSH2 P43246 N263Q 263 N Q 0.058 Neutral MSH2 P43246 N263R 263 N R 0.552 Pathogenic MSH2 P43246 N263S 263 N S 0.04 Neutral MSH2 P43246 N263T 263 N T 0.576 Pathogenic MSH2 P43246 N263V 263 N V 0.906 Pathogenic MSH2 P43246 N263W 263 N W 0.944 Pathogenic MSH2 P43246 N263Y 263 N Y 0.95 Pathogenic MSH2 P43246 Q264A 264 Q A 0.492 Neutral MSH2 P43246 Q264C 264 Q C 0.45 Neutral MSH2 P43246 Q264D 264 Q D 0.09 Neutral MSH2 P43246 Q264E 264 Q E 0.052 Neutral MSH2 P43246 Q264F 264 Q F 0.806 Pathogenic MSH2 P43246 Q264G 264 Q G 0.476 Neutral MSH2 P43246 Q264H 264 Q H 0.832 Pathogenic 4 MSH2 P43246 Q264I 264 Q I 0.876 Pathogenic MSH2 P43246 Q264K 264 Q K 0.122 Neutral MSH2 P43246 Q264L 264 Q L 0.262 Neutral MSH2 P43246 Q264M 264 Q M 0.746 Pathogenic MSH2 P43246 Q264N 264 Q N 0.146 Neutral MSH2 P43246 Q264P 264 Q P 0.35 Neutral MSH2 P43246 Q264R 264 Q R 0.318 Neutral MSH2 P43246 Q264S 264 Q S 0.14 Neutral MSH2 P43246 Q264T 264 Q T 0.062 Neutral MSH2 P43246 Q264V 264 Q V 0.166 Neutral MSH2 P43246 Q264W 264 Q W 0.924 Pathogenic MSH2 P43246 Q264Y 264 Q Y 0.886 Pathogenic MSH2 P43246 V265A 265 V A 0.02 Neutral MSH2 P43246 V265C 265 V C 0.068 Neutral MSH2 P43246 V265D 265 V D 0.554 Pathogenic MSH2 P43246 V265E 265 V E 0.542 Pathogenic MSH2 P43246 V265F 265 V F 0.45 Neutral MSH2 P43246 V265G 265 V G 0.508 Pathogenic MSH2 P43246 V265H 265 V H 0.16 Neutral MSH2 P43246 V265I 265 V I 0.058 Neutral MSH2 P43246 V265K 265 V K 0.752 Pathogenic MSH2 P43246 V265L 265 V L 0.054 Neutral MSH2 P43246 V265M 265 V M 0.152 Neutral MSH2 P43246 V265N 265 V N 0.088 Neutral MSH2 P43246 V265P 265 V P 0.82 Pathogenic MSH2 P43246 V265Q 265 V Q 0.12 Neutral MSH2 P43246 V265R 265 V R 0.832 Pathogenic MSH2 P43246 V265S 265 V S 0.286 Neutral MSH2 P43246 V265T 265 V T 0.022 Neutral MSH2 P43246 V265W 265 V W 0.816 Pathogenic MSH2 P43246 V265Y 265 V Y 0.446 Neutral MSH2 P43246 A266C 266 A C 0.856 Pathogenic MSH2 P43246 A266D 266 A D 0.926 Pathogenic MSH2 P43246 A266E 266 A E 0.876 Pathogenic MSH2 P43246 A266F 266 A F 0.9 Pathogenic MSH2 P43246 A266G 266 A G 0.336 Neutral MSH2 P43246 A266H 266 A H 0.866 Pathogenic MSH2 P43246 A266I 266 A I 0.96 Pathogenic MSH2 P43246 A266K 266 A K 0.936 Pathogenic MSH2 P43246 A266L 266 A L 0.98 Pathogenic MSH2 P43246 A266M 266 A M 0.852 Pathogenic MSH2 P43246 A266N 266 A N 0.862 Pathogenic MSH2 P43246 A266P 266 A P 0.968 Pathogenic MSH2 P43246 A266Q 266 A Q 0.816 Pathogenic MSH2 P43246 A266R 266 A R 0.958 Pathogenic MSH2 P43246 A266S 266 A S 0.302 Neutral MSH2 P43246 A266T 266 A T 0.44 Neutral MSH2 P43246 A266V 266 A V 0.91 Pathogenic MSH2 P43246 A266W 266 A W 0.976 Pathogenic MSH2 P43246 A266Y 266 A Y 0.964 Pathogenic MSH2 P43246 V267A 267 V A 0.016 Neutral MSH2 P43246 V267C 267 V C 0.242 Neutral MSH2 P43246 V267D 267 V D 0.62 Pathogenic MSH2 P43246 V267E 267 V E 0.722 Pathogenic MSH2 P43246 V267F 267 V F 0.766 Pathogenic MSH2 P43246 V267G 267 V G 0.64 Pathogenic MSH2 P43246 V267H 267 V H 0.546 Pathogenic MSH2 P43246 V267I 267 V I 0.062 Neutral MSH2 P43246 V267K 267 V K 0.63 Pathogenic MSH2 P43246 V267L 267 V L 0.044 Neutral MSH2 P43246 V267M 267 V M 0.114 Neutral MSH2 P43246 V267N 267 V N 0.66 Pathogenic MSH2 P43246 V267P 267 V P 0.084 Neutral MSH2 P43246 V267Q 267 V Q 0.736 Pathogenic MSH2 P43246 V267R 267 V R 0.842 Pathogenic MSH2 P43246 V267S 267 V S 0.042 Neutral MSH2 P43246 V267T 267 V T 0.03 Neutral MSH2 P43246 V267W 267 V W 0.842 Pathogenic MSH2 P43246 V267Y 267 V Y 0.832 Pathogenic MSH2 P43246 S268A 268 S A 0.044 Neutral MSH2 P43246 S268C 268 S C 0.132 Neutral MSH2 P43246 S268D 268 S D 0.378 Neutral MSH2 P43246 S268E 268 S E 0.468 Neutral MSH2 P43246 S268F 268 S F 0.9 Pathogenic MSH2 P43246 S268G 268 S G 0.024 Neutral MSH2 P43246 S268H 268 S H 0.83 Pathogenic MSH2 P43246 S268I 268 S I 0.662 Pathogenic MSH2 P43246 S268K 268 S K 0.776 Pathogenic MSH2 P43246 S268L 268 S L 0.68 Pathogenic MSH2 P43246 S268M 268 S M 0.632 Pathogenic MSH2 P43246 S268N 268 S N 0.21 Neutral MSH2 P43246 S268P 268 S P 0.356 Neutral MSH2 P43246 S268Q 268 S Q 0.478 Neutral MSH2 P43246 S268R 268 S R 0.678 Pathogenic MSH2 P43246 S268T 268 S T 0.074 Neutral MSH2 P43246 S268V 268 S V 0.766 Pathogenic MSH2 P43246 S268W 268 S W 0.938 Pathogenic MSH2 P43246 S268Y 268 S Y 0.924 Pathogenic MSH2 P43246 S269A 269 S A 0.18 Neutral MSH2 P43246 S269C 269 S C 0.248 Neutral MSH2 P43246 S269D 269 S D 0.83 Pathogenic MSH2 P43246 S269E 269 S E 0.924 Pathogenic MSH2 P43246 S269F 269 S F 0.98 Pathogenic MSH2 P43246 S269G 269 S G 0.154 Neutral MSH2 P43246 S269H 269 S H 0.944 Pathogenic MSH2 P43246 S269I 269 S I 0.86 Pathogenic MSH2 P43246 S269K 269 S K 0.918 Pathogenic MSH2 P43246 S269L 269 S L 0.896 Pathogenic MSH2 P43246 S269M 269 S M 0.998 Pathogenic MSH2 P43246 S269N 269 S N 0.784 Pathogenic MSH2 P43246 S269P 269 S P 0.626 Pathogenic MSH2 P43246 S269Q 269 S Q 0.89 Pathogenic MSH2 P43246 S269R 269 S R 0.944 Pathogenic MSH2 P43246 S269T 269 S T 0.872 Pathogenic MSH2 P43246 S269V 269 S V 0.956 Pathogenic MSH2 P43246 S269W 269 S W 0.98 Pathogenic MSH2 P43246 S269Y 269 S Y 0.98 Pathogenic MSH2 P43246 P27A 27 P A 0.156 Neutral MSH2 P43246 P27C 27 P C 0.922 Pathogenic MSH2 P43246 P27D 27 P D 0.172 Neutral MSH2 P43246 P27E 27 P E 0.258 Neutral MSH2 P43246 P27F 27 P F 0.698 Pathogenic MSH2 P43246 P27G 27 P G 0.108 Neutral MSH2 P43246 P27H 27 P H 0.992 Pathogenic MSH2 P43246 P27I 27 P I 0.896 Pathogenic MSH2 P43246 P27K 27 P K 0.954 Pathogenic MSH2 P43246 P27L 27 P L 0.952 Pathogenic MSH2 P43246 P27M 27 P M 0.97 Pathogenic MSH2 P43246 P27N 27 P N 0.314 Neutral MSH2 P43246 P27Q 27 P Q 0.868 Pathogenic MSH2 P43246 P27R 27 P R 0.704 Pathogenic MSH2 P43246 P27S 27 P S 0.098 Neutral MSH2 P43246 P27T 27 P T 0.658 Pathogenic MSH2 P43246 P27V 27 P V 0.168 Neutral MSH2 P43246 P27W 27 P W 0.912 Pathogenic MSH2 P43246 P27Y 27 P Y 0.896 Pathogenic MSH2 P43246 L270A 270 L A 0.084 Neutral MSH2 P43246 L270C 270 L C 0.104 Neutral MSH2 P43246 L270D 270 L D 0.912 Pathogenic MSH2 P43246 L270E 270 L E 0.89 Pathogenic MSH2 P43246 L270F 270 L F 0.774 Pathogenic MSH2 P43246 L270G 270 L G 0.81 Pathogenic MSH2 P43246 L270H 270 L H 0.798 Pathogenic MSH2 P43246 L270I 270 L I 0.42 Neutral MSH2 P43246 L270K 270 L K 0.744 Pathogenic MSH2 P43246 L270M 270 L M 0.746 Pathogenic MSH2 P43246 L270N 270 L N 0.782 Pathogenic MSH2 P43246 L270P 270 L P 0.992 Pathogenic MSH2 P43246 L270Q 270 L Q 0.622 Pathogenic MSH2 P43246 L270R 270 L R 0.996 Pathogenic MSH2 P43246 L270S 270 L S 0.338 Neutral MSH2 P43246 L270T 270 L T 0.094 Neutral MSH2 P43246 L270V 270 L V 0.08 Neutral MSH2 P43246 L270W 270 L W 0.926 Pathogenic MSH2 P43246 L270Y 270 L Y 0.884 Pathogenic MSH2 P43246 S271A 271 S A 0.09 Neutral MSH2 P43246 S271C 271 S C 0.344 Neutral MSH2 P43246 S271D 271 S D 0.598 Pathogenic MSH2 P43246 S271E 271 S E 0.606 Pathogenic MSH2 P43246 S271F 271 S F 0.898 Pathogenic MSH2 P43246 S271G 271 S G 0.048 Neutral MSH2 P43246 S271H 271 S H 0.654 Pathogenic MSH2 P43246 S271I 271 S I 0.612 Pathogenic MSH2 P43246 S271K 271 S K 0.47 Neutral MSH2 P43246 S271L 271 S L 0.688 Pathogenic MSH2 P43246 S271M 271 S M 0.95 Pathogenic MSH2 P43246 S271N 271 S N 0.088 Neutral MSH2 P43246 S271P 271 S P 0.714 Pathogenic MSH2 P43246 S271Q 271 S Q 0.734 Pathogenic MSH2 P43246 S271R 271 S R 0.496 Neutral MSH2 P43246 S271T 271 S T 0.198 Neutral MSH2 P43246 S271V 271 S V 0.774 Pathogenic MSH2 P43246 S271W 271 S W 0.912 Pathogenic MSH2 P43246 S271Y 271 S Y 0.9 Pathogenic MSH2 P43246 A272C 272 A C 0.392 Neutral MSH2 P43246 A272D 272 A D 0.958 Pathogenic MSH2 P43246 A272E 272 A E 0.976 Pathogenic MSH2 P43246 A272F 272 A F 0.996 Pathogenic MSH2 P43246 A272G 272 A G 0.124 Neutral MSH2 P43246 A272H 272 A H 0.942 Pathogenic MSH2 P43246 A272I 272 A I 0.968 Pathogenic MSH2 P43246 A272K 272 A K 0.87 Pathogenic MSH2 P43246 A272L 272 A L 0.814 Pathogenic MSH2 P43246 A272M 272 A M 0.91 Pathogenic MSH2 P43246 A272N 272 A N 0.876 Pathogenic MSH2 P43246 A272P 272 A P 0.52 Pathogenic MSH2 P43246 A272Q 272 A Q 0.894 Pathogenic MSH2 P43246 A272R 272 A R 0.978 Pathogenic MSH2 P43246 A272S 272 A S 0.134 Neutral MSH2 P43246 A272T 272 A T 0.274 Neutral MSH2 P43246 A272V 272 A V 0.462 Neutral MSH2 P43246 A272W 272 A W 0.996 Pathogenic MSH2 P43246 A272Y 272 A Y 0.972 Pathogenic MSH2 P43246 V273A 273 V A 0.068 Neutral MSH2 P43246 V273C 273 V C 0.72 Pathogenic MSH2 P43246 V273D 273 V D 0.862 Pathogenic MSH2 P43246 V273E 273 V E 0.976 Pathogenic MSH2 P43246 V273F 273 V F 0.89 Pathogenic MSH2 P43246 V273G 273 V G 0.886 Pathogenic MSH2 P43246 V273H 273 V H 0.834 Pathogenic MSH2 P43246 V273I 273 V I 0.208 Neutral MSH2 P43246 V273K 273 V K 0.988 Pathogenic MSH2 P43246 V273L 273 V L 0.192 Neutral MSH2 P43246 V273M 273 V M 0.832 Pathogenic MSH2 P43246 V273N 273 V N 0.92 Pathogenic MSH2 P43246 V273P 273 V P 0.98 Pathogenic MSH2 P43246 V273Q 273 V Q 0.982 Pathogenic MSH2 P43246 V273R 273 V R 0.952 Pathogenic MSH2 P43246 V273S 273 V S 0.374 Neutral MSH2 P43246 V273T 273 V T 0.324 Neutral MSH2 P43246 V273W 273 V W 0.918 Pathogenic MSH2 P43246 V273Y 273 V Y 0.706 Pathogenic MSH2 P43246 I274A 274 I A 0.534 Pathogenic MSH2 P43246 I274C 274 I C 0.65 Pathogenic MSH2 P43246 I274D 274 I D 0.74 Pathogenic MSH2 P43246 I274E 274 I E 0.746 Pathogenic MSH2 P43246 I274F 274 I F 0.958 Pathogenic MSH2 P43246 I274G 274 I G 0.804 Pathogenic MSH2 P43246 I274H 274 I H 0.892 Pathogenic MSH2 P43246 I274K 274 I K 0.842 Pathogenic MSH2 P43246 I274L 274 I L 0.078 Neutral MSH2 P43246 I274M 274 I M 0.184 Neutral MSH2 P43246 I274N 274 I N 0.764 Pathogenic MSH2 P43246 I274P 274 I P 0.928 Pathogenic MSH2 P43246 I274Q 274 I Q 0.778 Pathogenic MSH2 P43246 I274R 274 I R 0.864 Pathogenic MSH2 P43246 I274S 274 I S 0.646 Pathogenic MSH2 P43246 I274T 274 I T 0.166 Neutral MSH2 P43246 I274V 274 I V 0.108 Neutral MSH2 P43246 I274W 274 I W 0.99 Pathogenic MSH2 P43246 I274Y 274 I Y 0.978 Pathogenic MSH2 P43246 K275A 275 K A 0.07 Neutral MSH2 P43246 K275C 275 K C 0.22 Neutral MSH2 P43246 K275D 275 K D 0.136 Neutral MSH2 P43246 K275E 275 K E 0.078 Neutral MSH2 P43246 K275F 275 K F 0.854 Pathogenic MSH2 P43246 K275G 275 K G 0.098 Neutral MSH2 P43246 K275H 275 K H 0.018 Neutral MSH2 P43246 K275I 275 K I 0.738 Pathogenic MSH2 P43246 K275L 275 K L 0.674 Pathogenic MSH2 P43246 K275M 275 K M 0.652 Pathogenic MSH2 P43246 K275N 275 K N 0.024 Neutral MSH2 P43246 K275P 275 K P 0.826 Pathogenic MSH2 P43246 K275Q 275 K Q 0.048 Neutral MSH2 P43246 K275R 275 K R 0.036 Neutral MSH2 P43246 K275S 275 K S 0.022 Neutral MSH2 P43246 K275T 275 K T 0.032 Neutral MSH2 P43246 K275V 275 K V 0.362 Neutral MSH2 P43246 K275W 275 K W 0.97 Pathogenic MSH2 P43246 K275Y 275 K Y 0.93 Pathogenic MSH2 P43246 F276A 276 F A 0.462 Neutral MSH2 P43246 F276C 276 F C 0.638 Pathogenic MSH2 P43246 F276D 276 F D 0.75 Pathogenic MSH2 P43246 F276E 276 F E 0.816 Pathogenic MSH2 P43246 F276G 276 F G 0.466 Neutral MSH2 P43246 F276H 276 F H 0.324 Neutral MSH2 P43246 F276I 276 F I 0.602 Pathogenic MSH2 P43246 F276K 276 F K 0.8 Pathogenic MSH2 P43246 F276L 276 F L 0.172 Neutral MSH2 P43246 F276M 276 F M 0.71 Pathogenic MSH2 P43246 F276N 276 F N 0.666 Pathogenic MSH2 P43246 F276P 276 F P 0.93 Pathogenic MSH2 P43246 F276Q 276 F Q 0.692 Pathogenic MSH2 P43246 F276R 276 F R 0.88 Pathogenic MSH2 P43246 F276S 276 F S 0.76 Pathogenic MSH2 P43246 F276T 276 F T 0.348 Neutral MSH2 P43246 F276V 276 F V 0.82 Pathogenic MSH2 P43246 F276W 276 F W 0.93 Pathogenic MSH2 P43246 F276Y 276 F Y 0.358 Neutral MSH2 P43246 L277A 277 L A 0.704 Pathogenic MSH2 P43246 L277C 277 L C 0.82 Pathogenic MSH2 P43246 L277D 277 L D 0.888 Pathogenic MSH2 P43246 L277E 277 L E 0.868 Pathogenic MSH2 P43246 L277F 277 L F 0.906 Pathogenic MSH2 P43246 L277G 277 L G 0.826 Pathogenic MSH2 P43246 L277H 277 L H 0.908 Pathogenic MSH2 P43246 L277I 277 L I 0.298 Neutral MSH2 P43246 L277K 277 L K 0.724 Pathogenic MSH2 P43246 L277M 277 L M 0.184 Neutral MSH2 P43246 L277N 277 L N 0.764 Pathogenic MSH2 P43246 L277P 277 L P 0.994 Pathogenic MSH2 P43246 L277Q 277 L Q 0.4 Neutral MSH2 P43246 L277R 277 L R 0.978 Pathogenic MSH2 P43246 L277S 277 L S 0.316 Neutral MSH2 P43246 L277T 277 L T 0.276 Neutral MSH2 P43246 L277V 277 L V 0.182 Neutral MSH2 P43246 L277W 277 L W 0.892 Pathogenic MSH2 P43246 L277Y 277 L Y 0.88 Pathogenic MSH2 P43246 E278A 278 E A 0.22 Neutral MSH2 P43246 E278C 278 E C 0.454 Neutral MSH2 P43246 E278D 278 E D 0.022 Neutral MSH2 P43246 E278F 278 E F 0.834 Pathogenic MSH2 P43246 E278G 278 E G 0.026 Neutral MSH2 P43246 E278H 278 E H 0.592 Pathogenic MSH2 P43246 E278I 278 E I 0.902 Pathogenic MSH2 P43246 E278K 278 E K 0.704 Pathogenic MSH2 P43246 E278L 278 E L 0.876 Pathogenic MSH2 P43246 E278M 278 E M 0.68 Pathogenic MSH2 P43246 E278N 278 E N 0.02 Neutral MSH2 P43246 E278P 278 E P 0.862 Pathogenic MSH2 P43246 E278Q 278 E Q 0.02 Neutral MSH2 P43246 E278R 278 E R 0.532 Pathogenic MSH2 P43246 E278S 278 E S 0.044 Neutral MSH2 P43246 E278T 278 E T 0.592 Pathogenic MSH2 P43246 E278V 278 E V 0.818 Pathogenic MSH2 P43246 E278W 278 E W 0.968 Pathogenic MSH2 P43246 E278Y 278 E Y 0.906 Pathogenic MSH2 P43246 L279A 279 L A 0.174 Neutral MSH2 P43246 L279C 279 L C 0.814 Pathogenic MSH2 P43246 L279D 279 L D 0.898 Pathogenic MSH2 P43246 L279E 279 L E 0.878 Pathogenic MSH2 P43246 L279F 279 L F 0.974 Pathogenic MSH2 P43246 L279G 279 L G 0.814 Pathogenic MSH2 P43246 L279H 279 L H 0.906 Pathogenic MSH2 P43246 L279I 279 L I 0.238 Neutral MSH2 P43246 L279K 279 L K 0.76 Pathogenic MSH2 P43246 L279M 279 L M 0.264 Neutral MSH2 P43246 L279N 279 L N 0.768 Pathogenic MSH2 P43246 L279P 279 L P 0.992 Pathogenic MSH2 P43246 L279Q 279 L Q 0.734 Pathogenic MSH2 P43246 L279R 279 L R 0.984 Pathogenic MSH2 P43246 L279S 279 L S 0.648 Pathogenic MSH2 P43246 L279T 279 L T 0.618 Pathogenic MSH2 P43246 L279V 279 L V 0.06 Neutral MSH2 P43246 L279W 279 L W 0.938 Pathogenic MSH2 P43246 L279Y 279 L Y 0.9 Pathogenic MSH2 P43246 E28A 28 E A 0.104 Neutral MSH2 P43246 E28C 28 E C 0.152 Neutral MSH2 P43246 E28D 28 E D 0.008 Neutral MSH2 P43246 E28F 28 E F 0.272 Neutral MSH2 P43246 E28G 28 E G 0.112 Neutral MSH2 P43246 E28H 28 E H 0.064 Neutral MSH2 P43246 E28I 28 E I 0.38 Neutral MSH2 P43246 E28K 28 E K 0.01 Neutral MSH2 P43246 E28L 28 E L 0.266 Neutral MSH2 P43246 E28M 28 E M 0.358 Neutral MSH2 P43246 E28N 28 E N 0.006 Neutral MSH2 P43246 E28P 28 E P 0.076 Neutral MSH2 P43246 E28Q 28 E Q 0.002 Neutral MSH2 P43246 E28R 28 E R 0.142 Neutral MSH2 P43246 E28S 28 E S 0.022 Neutral MSH2 P43246 E28T 28 E T 0.02 Neutral MSH2 P43246 E28V 28 E V 0.474 Neutral MSH2 P43246 E28W 28 E W 0.772 Pathogenic MSH2 P43246 E28Y 28 E Y 0.644 Pathogenic MSH2 P43246 L280A 280 L A 0.196 Neutral MSH2 P43246 L280C 280 L C 0.284 Neutral MSH2 P43246 L280D 280 L D 0.888 Pathogenic MSH2 P43246 L280E 280 L E 0.874 Pathogenic MSH2 P43246 L280F 280 L F 0.79 Pathogenic MSH2 P43246 L280G 280 L G 0.79 Pathogenic MSH2 P43246 L280H 280 L H 0.816 Pathogenic MSH2 P43246 L280I 280 L I 0.446 Neutral MSH2 P43246 L280K 280 L K 0.744 Pathogenic MSH2 P43246 L280M 280 L M 0.18 Neutral MSH2 P43246 L280N 280 L N 0.754 Pathogenic MSH2 P43246 L280P 280 L P 0.99 Pathogenic MSH2 P43246 L280Q 280 L Q 0.622 Pathogenic MSH2 P43246 L280R 280 L R 0.99 Pathogenic MSH2 P43246 L280S 280 L S 0.186 Neutral MSH2 P43246 L280T 280 L T 0.118 Neutral MSH2 P43246 L280V 280 L V 0.082 Neutral MSH2 P43246 L280W 280 L W 0.94 Pathogenic MSH2 P43246 L280Y 280 L Y 0.906 Pathogenic MSH2 P43246 S281A 281 S A 0.04 Neutral MSH2 P43246 S281C 281 S C 0.506 Pathogenic MSH2 P43246 S281D 281 S D 0.148 Neutral MSH2 P43246 S281E 281 S E 0.63 Pathogenic MSH2 P43246 S281F 281 S F 0.896 Pathogenic MSH2 P43246 S281G 281 S G 0.022 Neutral MSH2 P43246 S281H 281 S H 0.482 Neutral MSH2 P43246 S281I 281 S I 0.632 Pathogenic MSH2 P43246 S281K 281 S K 0.624 Pathogenic MSH2 P43246 S281L 281 S L 0.534 Pathogenic MSH2 P43246 S281M 281 S M 0.894 Pathogenic MSH2 P43246 S281N 281 S N 0.052 Neutral MSH2 P43246 S281P 281 S P 0.662 Pathogenic MSH2 P43246 S281Q 281 S Q 0.482 Neutral MSH2 P43246 S281R 281 S R 0.586 Pathogenic MSH2 P43246 S281T 281 S T 0.044 Neutral MSH2 P43246 S281V 281 S V 0.826 Pathogenic MSH2 P43246 S281W 281 S W 0.954 Pathogenic MSH2 P43246 S281Y 281 S Y 0.936 Pathogenic MSH2 P43246 D282A 282 D A 0.772 Pathogenic MSH2 P43246 D282C 282 D C 0.846 Pathogenic MSH2 P43246 D282E 282 D E 0.208 Neutral MSH2 P43246 D282F 282 D F 0.972 Pathogenic MSH2 P43246 D282G 282 D G 0.368 Neutral MSH2 P43246 D282H 282 D H 0.576 Pathogenic MSH2 P43246 D282I 282 D I 0.964 Pathogenic MSH2 P43246 D282K 282 D K 0.352 Neutral MSH2 P43246 D282L 282 D L 0.96 Pathogenic MSH2 P43246 D282M 282 D M 0.94 Pathogenic MSH2 P43246 D282N 282 D N 0.196 Neutral MSH2 P43246 D282P 282 D P 0.872 Pathogenic MSH2 P43246 D282Q 282 D Q 0.526 Pathogenic MSH2 P43246 D282R 282 D R 0.95 Pathogenic MSH2 P43246 D282S 282 D S 0.134 Neutral MSH2 P43246 D282T 282 D T 0.744 Pathogenic MSH2 P43246 D282V 282 D V 0.756 Pathogenic MSH2 P43246 D282W 282 D W 0.976 Pathogenic MSH2 P43246 D282Y 282 D Y 0.966 Pathogenic MSH2 P43246 D283A 283 D A 0.106 Neutral MSH2 P43246 D283C 283 D C 0.764 Pathogenic MSH2 P43246 D283E 283 D E 0.04 Neutral MSH2 P43246 D283F 283 D F 0.938 Pathogenic MSH2 P43246 D283G 283 D G 0.398 Neutral MSH2 P43246 D283H 283 D H 0.46 Neutral MSH2 P43246 D283I 283 D I 0.914 Pathogenic MSH2 P43246 D283K 283 D K 0.736 Pathogenic MSH2 P43246 D283L 283 D L 0.8 Pathogenic MSH2 P43246 D283M 283 D M 0.822 Pathogenic MSH2 P43246 D283N 283 D N 0.076 Neutral MSH2 P43246 D283P 283 D P 0.09 Neutral MSH2 P43246 D283Q 283 D Q 0.026 Neutral MSH2 P43246 D283R 283 D R 0.62 Pathogenic MSH2 P43246 D283S 283 D S 0.012 Neutral MSH2 P43246 D283T 283 D T 0.312 Neutral MSH2 P43246 D283V 283 D V 0.19 Neutral MSH2 P43246 D283W 283 D W 0.972 Pathogenic MSH2 P43246 D283Y 283 D Y 0.966 Pathogenic MSH2 P43246 S284A 284 S A 0.06 Neutral MSH2 P43246 S284C 284 S C 0.534 Pathogenic MSH2 P43246 S284D 284 S D 0.096 Neutral MSH2 P43246 S284E 284 S E 0.474 Neutral MSH2 P43246 S284F 284 S F 0.886 Pathogenic MSH2 P43246 S284G 284 S G 0.03 Neutral MSH2 P43246 S284H 284 S H 0.574 Pathogenic MSH2 P43246 S284I 284 S I 0.644 Pathogenic MSH2 P43246 S284K 284 S K 0.77 Pathogenic MSH2 P43246 S284L 284 S L 0.226 Neutral MSH2 P43246 S284M 284 S M 0.944 Pathogenic MSH2 P43246 S284N 284 S N 0.076 Neutral MSH2 P43246 S284P 284 S P 0.688 Pathogenic MSH2 P43246 S284Q 284 S Q 0.498 Neutral MSH2 P43246 S284R 284 S R 0.576 Pathogenic MSH2 P43246 S284T 284 S T 0.07 Neutral MSH2 P43246 S284V 284 S V 0.722 Pathogenic MSH2 P43246 S284W 284 S W 0.91 Pathogenic MSH2 P43246 S284Y 284 S Y 0.896 Pathogenic MSH2 P43246 N285A 285 N A 0.784 Pathogenic MSH2 P43246 N285C 285 N C 0.722 Pathogenic MSH2 P43246 N285D 285 N D 0.448 Neutral MSH2 P43246 N285E 285 N E 0.538 Pathogenic MSH2 P43246 N285F 285 N F 0.946 Pathogenic MSH2 P43246 N285G 285 N G 0.27 Neutral MSH2 P43246 N285H 285 N H 0.39 Neutral MSH2 P43246 N285I 285 N I 0.93 Pathogenic MSH2 P43246 N285K 285 N K 0.882 Pathogenic MSH2 P43246 N285L 285 N L 0.736 Pathogenic MSH2 P43246 N285M 285 N M 0.81 Pathogenic MSH2 P43246 N285P 285 N P 0.828 Pathogenic MSH2 P43246 N285Q 285 N Q 0.224 Neutral MSH2 P43246 N285R 285 N R 0.948 Pathogenic MSH2 P43246 N285S 285 N S 0.146 Neutral MSH2 P43246 N285T 285 N T 0.338 Neutral MSH2 P43246 N285V 285 N V 0.386 Neutral MSH2 P43246 N285W 285 N W 0.96 Pathogenic MSH2 P43246 N285Y 285 N Y 0.782 Pathogenic MSH2 P43246 F286A 286 F A 0.212 Neutral MSH2 P43246 F286C 286 F C 0.562 Pathogenic MSH2 P43246 F286D 286 F D 0.464 Neutral MSH2 P43246 F286E 286 F E 0.178 Neutral MSH2 P43246 F286G 286 F G 0.312 Neutral MSH2 P43246 F286H 286 F H 0.088 Neutral MSH2 P43246 F286I 286 F I 0.218 Neutral MSH2 P43246 F286K 286 F K 0.858 Pathogenic MSH2 P43246 F286L 286 F L 0.08 Neutral MSH2 P43246 F286M 286 F M 0.12 Neutral MSH2 P43246 F286N 286 F N 0.454 Neutral MSH2 P43246 F286P 286 F P 0.874 Pathogenic MSH2 P43246 F286Q 286 F Q 0.768 Pathogenic MSH2 P43246 F286R 286 F R 0.546 Pathogenic MSH2 P43246 F286S 286 F S 0.228 Neutral MSH2 P43246 F286T 286 F T 0.36 Neutral MSH2 P43246 F286V 286 F V 0.396 Neutral MSH2 P43246 F286W 286 F W 0.84 Pathogenic MSH2 P43246 F286Y 286 F Y 0.202 Neutral MSH2 P43246 G287A 287 G A 0.658 Pathogenic MSH2 P43246 G287C 287 G C 0.94 Pathogenic MSH2 P43246 G287D 287 G D 0.586 Pathogenic MSH2 P43246 G287E 287 G E 0.692 Pathogenic MSH2 P43246 G287F 287 G F 0.988 Pathogenic MSH2 P43246 G287H 287 G H 0.788 Pathogenic MSH2 P43246 G287I 287 G I 0.978 Pathogenic MSH2 P43246 G287K 287 G K 0.906 Pathogenic MSH2 P43246 G287L 287 G L 0.988 Pathogenic MSH2 P43246 G287M 287 G M 0.994 Pathogenic MSH2 P43246 G287N 287 G N 0.516 Pathogenic MSH2 P43246 G287P 287 G P 0.982 Pathogenic MSH2 P43246 G287Q 287 G Q 0.744 Pathogenic MSH2 P43246 G287R 287 G R 0.756 Pathogenic MSH2 P43246 G287S 287 G S 0.322 Neutral MSH2 P43246 G287T 287 G T 0.918 Pathogenic MSH2 P43246 G287V 287 G V 0.99 Pathogenic MSH2 P43246 G287W 287 G W 0.938 Pathogenic MSH2 P43246 G287Y 287 G Y 0.986 Pathogenic MSH2 P43246 Q288A 288 Q A 0.118 Neutral MSH2 P43246 Q288C 288 Q C 0.498 Neutral MSH2 P43246 Q288D 288 Q D 0.558 Pathogenic MSH2 P43246 Q288E 288 Q E 0.044 Neutral MSH2 P43246 Q288F 288 Q F 0.842 Pathogenic MSH2 P43246 Q288G 288 Q G 0.454 Neutral MSH2 P43246 Q288H 288 Q H 0.084 Neutral MSH2 P43246 Q288I 288 Q I 0.894 Pathogenic MSH2 P43246 Q288K 288 Q K 0.054 Neutral MSH2 P43246 Q288L 288 Q L 0.748 Pathogenic MSH2 P43246 Q288M 288 Q M 0.734 Pathogenic MSH2 P43246 Q288N 288 Q N 0.078 Neutral MSH2 P43246 Q288P 288 Q P 0.844 Pathogenic MSH2 P43246 Q288R 288 Q R 0.092 Neutral MSH2 P43246 Q288S 288 Q S 0.084 Neutral MSH2 P43246 Q288T 288 Q T 0.03 Neutral MSH2 P43246 Q288V 288 Q V 0.84 Pathogenic MSH2 P43246 Q288W 288 Q W 0.92 Pathogenic MSH2 P43246 Q288Y 288 Q Y 0.888 Pathogenic MSH2 P43246 F289A 289 F A 0.462 Neutral MSH2 P43246 F289C 289 F C 0.206 Neutral MSH2 P43246 F289D 289 F D 0.772 Pathogenic MSH2 P43246 F289E 289 F E 0.838 Pathogenic MSH2 P43246 F289G 289 F G 0.47 Neutral MSH2 P43246 F289H 289 F H 0.702 Pathogenic MSH2 P43246 F289I 289 F I 0.612 Pathogenic MSH2 P43246 F289K 289 F K 0.82 Pathogenic MSH2 P43246 F289L 289 F L 0.182 Neutral MSH2 P43246 F289M 289 F M 0.724 Pathogenic MSH2 P43246 F289N 289 F N 0.688 Pathogenic MSH2 P43246 F289P 289 F P 0.944 Pathogenic MSH2 P43246 F289Q 289 F Q 0.708 Pathogenic MSH2 P43246 F289R 289 F R 0.904 Pathogenic MSH2 P43246 F289S 289 F S 0.796 Pathogenic MSH2 P43246 F289T 289 F T 0.598 Pathogenic MSH2 P43246 F289V 289 F V 0.86 Pathogenic MSH2 P43246 F289W 289 F W 0.666 Pathogenic MSH2 P43246 F289Y 289 F Y 0.358 Neutral MSH2 P43246 K29A 29 K A 0.068 Neutral MSH2 P43246 K29C 29 K C 0.1 Neutral MSH2 P43246 K29D 29 K D 0.012 Neutral MSH2 P43246 K29E 29 K E 0.026 Neutral MSH2 P43246 K29F 29 K F 0.786 Pathogenic MSH2 P43246 K29G 29 K G 0.356 Neutral MSH2 P43246 K29H 29 K H 0.392 Neutral MSH2 P43246 K29I 29 K I 0.896 Pathogenic MSH2 P43246 K29L 29 K L 0.86 Pathogenic MSH2 P43246 K29M 29 K M 0.662 Pathogenic MSH2 P43246 K29N 29 K N 0.028 Neutral MSH2 P43246 K29P 29 K P 0.084 Neutral MSH2 P43246 K29Q 29 K Q 0.052 Neutral MSH2 P43246 K29R 29 K R 0.088 Neutral MSH2 P43246 K29S 29 K S 0.028 Neutral MSH2 P43246 K29T 29 K T 0.04 Neutral MSH2 P43246 K29V 29 K V 0.222 Neutral MSH2 P43246 K29W 29 K W 0.98 Pathogenic MSH2 P43246 K29Y 29 K Y 0.934 Pathogenic MSH2 P43246 E290A 290 E A 0.234 Neutral MSH2 P43246 E290C 290 E C 0.43 Neutral MSH2 P43246 E290D 290 E D 0.1 Neutral MSH2 P43246 E290F 290 E F 0.814 Pathogenic MSH2 P43246 E290G 290 E G 0.168 Neutral MSH2 P43246 E290H 290 E H 0.08 Neutral MSH2 P43246 E290I 290 E I 0.23 Neutral MSH2 P43246 E290K 290 E K 0.05 Neutral MSH2 P43246 E290L 290 E L 0.852 Pathogenic MSH2 P43246 E290M 290 E M 0.664 Pathogenic MSH2 P43246 E290N 290 E N 0.166 Neutral MSH2 P43246 E290P 290 E P 0.862 Pathogenic MSH2 P43246 E290Q 290 E Q 0.018 Neutral MSH2 P43246 E290R 290 E R 0.104 Neutral MSH2 P43246 E290S 290 E S 0.034 Neutral MSH2 P43246 E290T 290 E T 0.03 Neutral MSH2 P43246 E290V 290 E V 0.112 Neutral MSH2 P43246 E290W 290 E W 0.942 Pathogenic MSH2 P43246 E290Y 290 E Y 0.888 Pathogenic MSH2 P43246 L291A 291 L A 0.654 Pathogenic MSH2 P43246 L291C 291 L C 0.778 Pathogenic MSH2 P43246 L291D 291 L D 0.89 Pathogenic MSH2 P43246 L291E 291 L E 0.868 Pathogenic MSH2 P43246 L291F 291 L F 0.506 Pathogenic MSH2 P43246 L291G 291 L G 0.804 Pathogenic MSH2 P43246 L291H 291 L H 0.888 Pathogenic MSH2 P43246 L291I 291 L I 0.19 Neutral MSH2 P43246 L291K 291 L K 0.756 Pathogenic MSH2 P43246 L291M 291 L M 0.18 Neutral MSH2 P43246 L291N 291 L N 0.754 Pathogenic MSH2 P43246 L291P 291 L P 0.992 Pathogenic MSH2 P43246 L291Q 291 L Q 0.706 Pathogenic MSH2 P43246 L291R 291 L R 0.984 Pathogenic MSH2 P43246 L291S 291 L S 0.636 Pathogenic MSH2 P43246 L291T 291 L T 0.61 Pathogenic MSH2 P43246 L291V 291 L V 0.108 Neutral MSH2 P43246 L291W 291 L W 0.942 Pathogenic MSH2 P43246 L291Y 291 L Y 0.904 Pathogenic MSH2 P43246 T292A 292 T A 0.04 Neutral MSH2 P43246 T292C 292 T C 0.312 Neutral MSH2 P43246 T292D 292 T D 0.134 Neutral MSH2 P43246 T292E 292 T E 0.094 Neutral MSH2 P43246 T292F 292 T F 0.416 Neutral MSH2 P43246 T292G 292 T G 0.242 Neutral MSH2 P43246 T292H 292 T H 0.322 Neutral MSH2 P43246 T292I 292 T I 0.096 Neutral MSH2 P43246 T292K 292 T K 0.048 Neutral MSH2 P43246 T292L 292 T L 0.256 Neutral MSH2 P43246 T292M 292 T M 0.468 Neutral MSH2 P43246 T292N 292 T N 0.026 Neutral MSH2 P43246 T292P 292 T P 0.512 Pathogenic MSH2 P43246 T292Q 292 T Q 0.03 Neutral MSH2 P43246 T292R 292 T R 0.386 Neutral MSH2 P43246 T292S 292 T S 0.026 Neutral MSH2 P43246 T292V 292 T V 0.06 Neutral MSH2 P43246 T292W 292 T W 0.886 Pathogenic MSH2 P43246 T292Y 292 T Y 0.526 Pathogenic MSH2 P43246 T293A 293 T A 0.126 Neutral MSH2 P43246 T293C 293 T C 0.504 Pathogenic MSH2 P43246 T293D 293 T D 0.388 Neutral MSH2 P43246 T293E 293 T E 0.146 Neutral MSH2 P43246 T293F 293 T F 0.754 Pathogenic MSH2 P43246 T293G 293 T G 0.28 Neutral MSH2 P43246 T293H 293 T H 0.208 Neutral MSH2 P43246 T293I 293 T I 0.206 Neutral MSH2 P43246 T293K 293 T K 0.092 Neutral MSH2 P43246 T293L 293 T L 0.16 Neutral MSH2 P43246 T293M 293 T M 0.238 Neutral MSH2 P43246 T293N 293 T N 0.012 Neutral MSH2 P43246 T293P 293 T P 0.328 Neutral MSH2 P43246 T293Q 293 T Q 0.03 Neutral MSH2 P43246 T293R 293 T R 0.484 Neutral MSH2 P43246 T293S 293 T S 0.008 Neutral MSH2 P43246 T293V 293 T V 0.728 Pathogenic MSH2 P43246 T293W 293 T W 0.942 Pathogenic MSH2 P43246 T293Y 293 T Y 0.938 Pathogenic MSH2 P43246 F294A 294 F A 0.408 Neutral MSH2 P43246 F294C 294 F C 0.56 Pathogenic MSH2 P43246 F294D 294 F D 0.814 Pathogenic MSH2 P43246 F294E 294 F E 0.906 Pathogenic MSH2 P43246 F294G 294 F G 0.492 Neutral MSH2 P43246 F294H 294 F H 0.132 Neutral MSH2 P43246 F294I 294 F I 0.116 Neutral MSH2 P43246 F294K 294 F K 0.866 Pathogenic MSH2 P43246 F294L 294 F L 0.086 Neutral MSH2 P43246 F294M 294 F M 0.628 Pathogenic MSH2 P43246 F294N 294 F N 0.738 Pathogenic MSH2 P43246 F294P 294 F P 0.878 Pathogenic MSH2 P43246 F294Q 294 F Q 0.774 Pathogenic MSH2 P43246 F294R 294 F R 0.924 Pathogenic MSH2 P43246 F294S 294 F S 0.682 Pathogenic MSH2 P43246 F294T 294 F T 0.538 Pathogenic MSH2 P43246 F294V 294 F V 0.18 Neutral MSH2 P43246 F294W 294 F W 0.836 Pathogenic MSH2 P43246 F294Y 294 F Y 0.204 Neutral MSH2 P43246 D295A 295 D A 0.706 Pathogenic MSH2 P43246 D295C 295 D C 0.886 Pathogenic MSH2 P43246 D295E 295 D E 0.266 Neutral MSH2 P43246 D295F 295 D F 0.972 Pathogenic MSH2 P43246 D295G 295 D G 0.38 Neutral MSH2 P43246 D295H 295 D H 0.616 Pathogenic MSH2 P43246 D295I 295 D I 0.95 Pathogenic MSH2 P43246 D295K 295 D K 0.39 Neutral MSH2 P43246 D295L 295 D L 0.956 Pathogenic MSH2 P43246 D295M 295 D M 0.936 Pathogenic MSH2 P43246 D295N 295 D N 0.118 Neutral MSH2 P43246 D295P 295 D P 0.89 Pathogenic MSH2 P43246 D295Q 295 D Q 0.246 Neutral MSH2 P43246 D295R 295 D R 0.646 Pathogenic MSH2 P43246 D295S 295 D S 0.11 Neutral MSH2 P43246 D295T 295 D T 0.448 Neutral MSH2 P43246 D295V 295 D V 0.972 Pathogenic MSH2 P43246 D295W 295 D W 0.978 Pathogenic MSH2 P43246 D295Y 295 D Y 0.972 Pathogenic MSH2 P43246 F296A 296 F A 0.246 Neutral MSH2 P43246 F296C 296 F C 0.672 Pathogenic MSH2 P43246 F296D 296 F D 0.784 Pathogenic MSH2 P43246 F296E 296 F E 0.492 Neutral MSH2 P43246 F296G 296 F G 0.478 Neutral MSH2 P43246 F296H 296 F H 0.334 Neutral MSH2 P43246 F296I 296 F I 0.264 Neutral MSH2 P43246 F296K 296 F K 0.828 Pathogenic MSH2 P43246 F296L 296 F L 0.166 Neutral MSH2 P43246 F296M 296 F M 0.324 Neutral MSH2 P43246 F296N 296 F N 0.7 Pathogenic MSH2 P43246 F296P 296 F P 0.488 Neutral MSH2 P43246 F296Q 296 F Q 0.172 Neutral MSH2 P43246 F296R 296 F R 0.542 Pathogenic MSH2 P43246 F296S 296 F S 0.426 Neutral MSH2 P43246 F296T 296 F T 0.152 Neutral MSH2 P43246 F296V 296 F V 0.246 Neutral MSH2 P43246 F296W 296 F W 0.94 Pathogenic MSH2 P43246 F296Y 296 F Y 0.72 Pathogenic MSH2 P43246 S297A 297 S A 0.054 Neutral MSH2 P43246 S297C 297 S C 0.52 Pathogenic MSH2 P43246 S297D 297 S D 0.092 Neutral MSH2 P43246 S297E 297 S E 0.484 Neutral MSH2 P43246 S297F 297 S F 0.896 Pathogenic MSH2 P43246 S297G 297 S G 0.034 Neutral MSH2 P43246 S297H 297 S H 0.54 Pathogenic MSH2 P43246 S297I 297 S I 0.638 Pathogenic MSH2 P43246 S297K 297 S K 0.48 Neutral MSH2 P43246 S297L 297 S L 0.656 Pathogenic MSH2 P43246 S297M 297 S M 0.982 Pathogenic MSH2 P43246 S297N 297 S N 0.07 Neutral MSH2 P43246 S297P 297 S P 0.668 Pathogenic MSH2 P43246 S297Q 297 S Q 0.552 Pathogenic MSH2 P43246 S297R 297 S R 0.828 Pathogenic MSH2 P43246 S297T 297 S T 0.088 Neutral MSH2 P43246 S297V 297 S V 0.824 Pathogenic MSH2 P43246 S297W 297 S W 0.954 Pathogenic MSH2 P43246 S297Y 297 S Y 0.912 Pathogenic MSH2 P43246 Q298A 298 Q A 0.38 Neutral MSH2 P43246 Q298C 298 Q C 0.294 Neutral MSH2 P43246 Q298D 298 Q D 0.732 Pathogenic MSH2 P43246 Q298E 298 Q E 0.224 Neutral MSH2 P43246 Q298F 298 Q F 0.912 Pathogenic MSH2 P43246 Q298G 298 Q G 0.304 Neutral MSH2 P43246 Q298H 298 Q H 0.348 Neutral MSH2 P43246 Q298I 298 Q I 0.942 Pathogenic MSH2 P43246 Q298K 298 Q K 0.484 Neutral MSH2 P43246 Q298L 298 Q L 0.532 Pathogenic MSH2 P43246 Q298M 298 Q M 0.718 Pathogenic MSH2 P43246 Q298N 298 Q N 0.162 Neutral MSH2 P43246 Q298P 298 Q P 0.906 Pathogenic MSH2 P43246 Q298R 298 Q R 0.294 Neutral MSH2 P43246 Q298S 298 Q S 0.222 Neutral MSH2 P43246 Q298T 298 Q T 0.644 Pathogenic MSH2 P43246 Q298V 298 Q V 0.912 Pathogenic MSH2 P43246 Q298W 298 Q W 0.95 Pathogenic MSH2 P43246 Q298Y 298 Q Y 0.94 Pathogenic MSH2 P43246 Y299A 299 Y A 0.442 Neutral MSH2 P43246 Y299C 299 Y C 0.68 Pathogenic MSH2 P43246 Y299D 299 Y D 0.838 Pathogenic MSH2 P43246 Y299E 299 Y E 0.738 Pathogenic MSH2 P43246 Y299F 299 Y F 0.14 Neutral MSH2 P43246 Y299G 299 Y G 0.49 Neutral MSH2 P43246 Y299H 299 Y H 0.592 Pathogenic MSH2 P43246 Y299I 299 Y I 0.35 Neutral MSH2 P43246 Y299K 299 Y K 0.822 Pathogenic MSH2 P43246 Y299L 299 Y L 0.284 Neutral MSH2 P43246 Y299M 299 Y M 0.678 Pathogenic MSH2 P43246 Y299N 299 Y N 0.73 Pathogenic MSH2 P43246 Y299P 299 Y P 0.798 Pathogenic MSH2 P43246 Y299Q 299 Y Q 0.636 Pathogenic MSH2 P43246 Y299R 299 Y R 0.754 Pathogenic MSH2 P43246 Y299S 299 Y S 0.49 Neutral MSH2 P43246 Y299T 299 Y T 0.676 Pathogenic MSH2 P43246 Y299V 299 Y V 0.708 Pathogenic MSH2 P43246 Y299W 299 Y W 0.91 Pathogenic MSH2 P43246 V3A 3 V A 0.054 Neutral MSH2 P43246 V3C 3 V C 0.058 Neutral MSH2 P43246 V3D 3 V D 0.128 Neutral MSH2 P43246 V3E 3 V E 0.214 Neutral MSH2 P43246 V3F 3 V F 0.176 Neutral MSH2 P43246 V3G 3 V G 0.198 Neutral MSH2 P43246 V3H 3 V H 0.116 Neutral MSH2 P43246 V3I 3 V I 0.038 Neutral MSH2 P43246 V3K 3 V K 0.158 Neutral MSH2 P43246 V3L 3 V L 0 Neutral MSH2 P43246 V3M 3 V M 0.08 Neutral MSH2 P43246 V3N 3 V N 0.142 Neutral MSH2 P43246 V3P 3 V P 0.092 Neutral MSH2 P43246 V3Q 3 V Q 0.23 Neutral MSH2 P43246 V3R 3 V R 0.288 Neutral MSH2 P43246 V3S 3 V S 0.012 Neutral MSH2 P43246 V3T 3 V T 0.03 Neutral MSH2 P43246 V3W 3 V W 0.348 Neutral MSH2 P43246 V3Y 3 V Y 0.26 Neutral MSH2 P43246 P30A 30 P A 0.07 Neutral MSH2 P43246 P30C 30 P C 0.552 Pathogenic MSH2 P43246 P30D 30 P D 0.04 Neutral MSH2 P43246 P30E 30 P E 0.136 Neutral MSH2 P43246 P30F 30 P F 0.9 Pathogenic MSH2 P43246 P30G 30 P G 0.244 Neutral MSH2 P43246 P30H 30 P H 0.8 Pathogenic MSH2 P43246 P30I 30 P I 0.674 Pathogenic MSH2 P43246 P30K 30 P K 0.11 Neutral MSH2 P43246 P30L 30 P L 0.086 Neutral MSH2 P43246 P30M 30 P M 0.668 Pathogenic MSH2 P43246 P30N 30 P N 0.232 Neutral MSH2 P43246 P30Q 30 P Q 0.572 Pathogenic MSH2 P43246 P30R 30 P R 0.486 Neutral MSH2 P43246 P30S 30 P S 0.032 Neutral MSH2 P43246 P30T 30 P T 0.046 Neutral MSH2 P43246 P30V 30 P V 0.07 Neutral MSH2 P43246 P30W 30 P W 0.88 Pathogenic MSH2 P43246 P30Y 30 P Y 0.862 Pathogenic MSH2 P43246 M300A 300 M A 0.69 Pathogenic MSH2 P43246 M300C 300 M C 0.626 Pathogenic MSH2 P43246 M300D 300 M D 0.866 Pathogenic MSH2 P43246 M300E 300 M E 0.81 Pathogenic MSH2 P43246 M300F 300 M F 0.776 Pathogenic MSH2 P43246 M300G 300 M G 0.54 Pathogenic MSH2 P43246 M300H 300 M H 0.938 Pathogenic MSH2 P43246 M300I 300 M I 0.306 Neutral MSH2 P43246 M300K 300 M K 0.952 Pathogenic MSH2 P43246 M300L 300 M L 0.244 Neutral MSH2 P43246 M300N 300 M N 0.9 Pathogenic MSH2 P43246 M300P 300 M P 0.924 Pathogenic MSH2 P43246 M300Q 300 M Q 0.784 Pathogenic MSH2 P43246 M300R 300 M R 0.944 Pathogenic MSH2 P43246 M300S 300 M S 0.916 Pathogenic MSH2 P43246 M300T 300 M T 0.764 Pathogenic MSH2 P43246 M300V 300 M V 0.138 Neutral MSH2 P43246 M300W 300 M W 0.946 Pathogenic MSH2 P43246 M300Y 300 M Y 0.954 Pathogenic MSH2 P43246 K301A 301 K A 0.548 Pathogenic MSH2 P43246 K301C 301 K C 0.438 Neutral MSH2 P43246 K301D 301 K D 0.614 Pathogenic MSH2 P43246 K301E 301 K E 0.73 Pathogenic MSH2 P43246 K301F 301 K F 0.968 Pathogenic MSH2 P43246 K301G 301 K G 0.534 Pathogenic MSH2 P43246 K301H 301 K H 0.09 Neutral MSH2 P43246 K301I 301 K I 0.334 Neutral MSH2 P43246 K301L 301 K L 0.978 Pathogenic MSH2 P43246 K301M 301 K M 0.92 Pathogenic MSH2 P43246 K301N 301 K N 0.66 Pathogenic MSH2 P43246 K301P 301 K P 0.922 Pathogenic MSH2 P43246 K301Q 301 K Q 0.738 Pathogenic MSH2 P43246 K301R 301 K R 0.112 Neutral MSH2 P43246 K301S 301 K S 0.706 Pathogenic MSH2 P43246 K301T 301 K T 0.18 Neutral MSH2 P43246 K301V 301 K V 0.346 Neutral MSH2 P43246 K301W 301 K W 0.992 Pathogenic MSH2 P43246 K301Y 301 K Y 0.986 Pathogenic MSH2 P43246 L302A 302 L A 0.708 Pathogenic MSH2 P43246 L302C 302 L C 0.818 Pathogenic MSH2 P43246 L302D 302 L D 0.904 Pathogenic MSH2 P43246 L302E 302 L E 0.888 Pathogenic MSH2 P43246 L302F 302 L F 0.876 Pathogenic MSH2 P43246 L302G 302 L G 0.856 Pathogenic MSH2 P43246 L302H 302 L H 0.904 Pathogenic MSH2 P43246 L302I 302 L I 0.662 Pathogenic MSH2 P43246 L302K 302 L K 0.712 Pathogenic MSH2 P43246 L302M 302 L M 0.382 Neutral MSH2 P43246 L302N 302 L N 0.814 Pathogenic MSH2 P43246 L302P 302 L P 0.992 Pathogenic MSH2 P43246 L302Q 302 L Q 0.77 Pathogenic MSH2 P43246 L302R 302 L R 0.98 Pathogenic MSH2 P43246 L302S 302 L S 0.69 Pathogenic MSH2 P43246 L302T 302 L T 0.614 Pathogenic MSH2 P43246 L302V 302 L V 0.428 Neutral MSH2 P43246 L302W 302 L W 0.88 Pathogenic MSH2 P43246 L302Y 302 L Y 0.888 Pathogenic MSH2 P43246 D303A 303 D A 0.794 Pathogenic MSH2 P43246 D303C 303 D C 0.89 Pathogenic MSH2 P43246 D303E 303 D E 0.82 Pathogenic MSH2 P43246 D303F 303 D F 0.978 Pathogenic MSH2 P43246 D303G 303 D G 0.954 Pathogenic MSH2 P43246 D303H 303 D H 0.638 Pathogenic MSH2 P43246 D303I 303 D I 0.972 Pathogenic MSH2 P43246 D303K 303 D K 0.928 Pathogenic MSH2 P43246 D303L 303 D L 0.978 Pathogenic MSH2 P43246 D303M 303 D M 0.956 Pathogenic MSH2 P43246 D303N 303 D N 0.864 Pathogenic MSH2 P43246 D303P 303 D P 0.91 Pathogenic MSH2 P43246 D303Q 303 D Q 0.636 Pathogenic MSH2 P43246 D303R 303 D R 0.958 Pathogenic MSH2 P43246 D303S 303 D S 0.59 Pathogenic MSH2 P43246 D303T 303 D T 0.808 Pathogenic MSH2 P43246 D303V 303 D V 0.992 Pathogenic MSH2 P43246 D303W 303 D W 0.982 Pathogenic MSH2 P43246 D303Y 303 D Y 0.976 Pathogenic MSH2 P43246 I304A 304 I A 0.116 Neutral MSH2 P43246 I304C 304 I C 0.434 Neutral MSH2 P43246 I304D 304 I D 0.62 Pathogenic MSH2 P43246 I304E 304 I E 0.606 Pathogenic MSH2 P43246 I304F 304 I F 0.684 Pathogenic MSH2 P43246 I304G 304 I G 0.174 Neutral MSH2 P43246 I304H 304 I H 0.082 Neutral MSH2 P43246 I304K 304 I K 0.612 Pathogenic MSH2 P43246 I304L 304 I L 0.466 Neutral MSH2 P43246 I304M 304 I M 0.034 Neutral MSH2 P43246 I304N 304 I N 0.14 Neutral MSH2 P43246 I304P 304 I P 0.742 Pathogenic MSH2 P43246 I304Q 304 I Q 0.528 Pathogenic MSH2 P43246 I304R 304 I R 0.736 Pathogenic MSH2 P43246 I304S 304 I S 0.092 Neutral MSH2 P43246 I304T 304 I T 0.33 Neutral MSH2 P43246 I304V 304 I V 0.006 Neutral MSH2 P43246 I304W 304 I W 0.87 Pathogenic MSH2 P43246 I304Y 304 I Y 0.804 Pathogenic MSH2 P43246 A305C 305 A C 0.702 Pathogenic MSH2 P43246 A305D 305 A D 0.958 Pathogenic MSH2 P43246 A305E 305 A E 0.976 Pathogenic MSH2 P43246 A305F 305 A F 0.996 Pathogenic MSH2 P43246 A305G 305 A G 0.128 Neutral MSH2 P43246 A305H 305 A H 0.942 Pathogenic MSH2 P43246 A305I 305 A I 0.968 Pathogenic MSH2 P43246 A305K 305 A K 0.976 Pathogenic MSH2 P43246 A305L 305 A L 1 Pathogenic MSH2 P43246 A305M 305 A M 0.91 Pathogenic MSH2 P43246 A305N 305 A N 0.878 Pathogenic MSH2 P43246 A305P 305 A P 0.466 Neutral MSH2 P43246 A305Q 305 A Q 0.894 Pathogenic MSH2 P43246 A305R 305 A R 0.978 Pathogenic MSH2 P43246 A305S 305 A S 0.14 Neutral MSH2 P43246 A305T 305 A T 0.412 Neutral MSH2 P43246 A305V 305 A V 0.942 Pathogenic MSH2 P43246 A305W 305 A W 0.996 Pathogenic MSH2 P43246 A305Y 305 A Y 0.972 Pathogenic MSH2 P43246 A306C 306 A C 0.864 Pathogenic MSH2 P43246 A306D 306 A D 0.924 Pathogenic MSH2 P43246 A306E 306 A E 0.878 Pathogenic MSH2 P43246 A306F 306 A F 0.968 Pathogenic MSH2 P43246 A306G 306 A G 0.502 Pathogenic MSH2 P43246 A306H 306 A H 0.868 Pathogenic MSH2 P43246 A306I 306 A I 0.96 Pathogenic MSH2 P43246 A306K 306 A K 0.938 Pathogenic MSH2 P43246 A306L 306 A L 0.982 Pathogenic MSH2 P43246 A306M 306 A M 0.856 Pathogenic MSH2 P43246 A306N 306 A N 0.856 Pathogenic MSH2 P43246 A306P 306 A P 0.966 Pathogenic MSH2 P43246 A306Q 306 A Q 0.816 Pathogenic MSH2 P43246 A306R 306 A R 0.956 Pathogenic MSH2 P43246 A306S 306 A S 0.322 Neutral MSH2 P43246 A306T 306 A T 0.464 Neutral MSH2 P43246 A306V 306 A V 0.912 Pathogenic MSH2 P43246 A306W 306 A W 0.978 Pathogenic MSH2 P43246 A306Y 306 A Y 0.964 Pathogenic MSH2 P43246 V307A 307 V A 0.096 Neutral MSH2 P43246 V307C 307 V C 0.462 Neutral MSH2 P43246 V307D 307 V D 0.654 Pathogenic MSH2 P43246 V307E 307 V E 0.756 Pathogenic MSH2 P43246 V307F 307 V F 0.482 Neutral MSH2 P43246 V307G 307 V G 0.668 Pathogenic MSH2 P43246 V307H 307 V H 0.604 Pathogenic MSH2 P43246 V307I 307 V I 0.098 Neutral MSH2 P43246 V307K 307 V K 0.804 Pathogenic MSH2 P43246 V307L 307 V L 0.11 Neutral MSH2 P43246 V307M 307 V M 0.126 Neutral MSH2 P43246 V307N 307 V N 0.702 Pathogenic MSH2 P43246 V307P 307 V P 0.846 Pathogenic MSH2 P43246 V307Q 307 V Q 0.532 Pathogenic MSH2 P43246 V307R 307 V R 0.854 Pathogenic MSH2 P43246 V307S 307 V S 0.088 Neutral MSH2 P43246 V307T 307 V T 0.11 Neutral MSH2 P43246 V307W 307 V W 0.848 Pathogenic MSH2 P43246 V307Y 307 V Y 0.476 Neutral MSH2 P43246 R308A 308 R A 0.18 Neutral MSH2 P43246 R308C 308 R C 0.894 Pathogenic MSH2 P43246 R308D 308 R D 0.826 Pathogenic MSH2 P43246 R308E 308 R E 0.784 Pathogenic MSH2 P43246 R308F 308 R F 0.952 Pathogenic MSH2 P43246 R308G 308 R G 0.082 Neutral MSH2 P43246 R308H 308 R H 0.53 Pathogenic MSH2 P43246 R308I 308 R I 0.96 Pathogenic MSH2 P43246 R308K 308 R K 0.404 Neutral MSH2 P43246 R308L 308 R L 0.434 Neutral MSH2 P43246 R308M 308 R M 0.764 Pathogenic MSH2 P43246 R308N 308 R N 0.34 Neutral MSH2 P43246 R308P 308 R P 0.954 Pathogenic MSH2 P43246 R308Q 308 R Q 0.104 Neutral MSH2 P43246 R308S 308 R S 0.162 Neutral MSH2 P43246 R308T 308 R T 0.372 Neutral MSH2 P43246 R308V 308 R V 0.64 Pathogenic MSH2 P43246 R308W 308 R W 0.948 Pathogenic MSH2 P43246 R308Y 308 R Y 0.792 Pathogenic MSH2 P43246 A309C 309 A C 0.864 Pathogenic MSH2 P43246 A309D 309 A D 0.926 Pathogenic MSH2 P43246 A309E 309 A E 0.878 Pathogenic MSH2 P43246 A309F 309 A F 0.968 Pathogenic MSH2 P43246 A309G 309 A G 0.336 Neutral MSH2 P43246 A309H 309 A H 0.868 Pathogenic MSH2 P43246 A309I 309 A I 0.96 Pathogenic MSH2 P43246 A309K 309 A K 0.938 Pathogenic MSH2 P43246 A309L 309 A L 0.982 Pathogenic MSH2 P43246 A309M 309 A M 0.854 Pathogenic MSH2 P43246 A309N 309 A N 0.862 Pathogenic MSH2 P43246 A309P 309 A P 0.968 Pathogenic MSH2 P43246 A309Q 309 A Q 0.818 Pathogenic MSH2 P43246 A309R 309 A R 0.958 Pathogenic MSH2 P43246 A309S 309 A S 0.31 Neutral MSH2 P43246 A309T 309 A T 0.442 Neutral MSH2 P43246 A309V 309 A V 0.912 Pathogenic MSH2 P43246 A309W 309 A W 0.978 Pathogenic MSH2 P43246 A309Y 309 A Y 0.964 Pathogenic MSH2 P43246 T31A 31 T A 0.004 Neutral MSH2 P43246 T31C 31 T C 0.114 Neutral MSH2 P43246 T31D 31 T D 0.032 Neutral MSH2 P43246 T31E 31 T E 0.044 Neutral MSH2 P43246 T31F 31 T F 0.416 Neutral MSH2 P43246 T31G 31 T G 0.054 Neutral MSH2 P43246 T31H 31 T H 0.218 Neutral MSH2 P43246 T31I 31 T I 0.154 Neutral MSH2 P43246 T31K 31 T K 0.02 Neutral MSH2 P43246 T31L 31 T L 0.042 Neutral MSH2 P43246 T31M 31 T M 0.27 Neutral MSH2 P43246 T31N 31 T N 0.008 Neutral MSH2 P43246 T31P 31 T P 0.028 Neutral MSH2 P43246 T31Q 31 T Q 0.056 Neutral MSH2 P43246 T31R 31 T R 0.34 Neutral MSH2 P43246 T31S 31 T S 0.004 Neutral MSH2 P43246 T31V 31 T V 0.334 Neutral MSH2 P43246 T31W 31 T W 0.704 Pathogenic MSH2 P43246 T31Y 31 T Y 0.666 Pathogenic MSH2 P43246 L310A 310 L A 0.708 Pathogenic MSH2 P43246 L310C 310 L C 0.52 Pathogenic MSH2 P43246 L310D 310 L D 0.904 Pathogenic MSH2 P43246 L310E 310 L E 0.888 Pathogenic MSH2 P43246 L310F 310 L F 0.876 Pathogenic MSH2 P43246 L310G 310 L G 0.856 Pathogenic MSH2 P43246 L310H 310 L H 0.904 Pathogenic MSH2 P43246 L310I 310 L I 0.938 Pathogenic MSH2 P43246 L310K 310 L K 0.712 Pathogenic MSH2 P43246 L310M 310 L M 0.382 Neutral MSH2 P43246 L310N 310 L N 0.814 Pathogenic MSH2 P43246 L310P 310 L P 0.992 Pathogenic 5 MSH2 P43246 L310Q 310 L Q 0.77 Pathogenic MSH2 P43246 L310R 310 L R 0.98 Pathogenic MSH2 P43246 L310S 310 L S 0.69 Pathogenic MSH2 P43246 L310T 310 L T 0.614 Pathogenic MSH2 P43246 L310V 310 L V 0.428 Neutral MSH2 P43246 L310W 310 L W 0.88 Pathogenic MSH2 P43246 L310Y 310 L Y 0.888 Pathogenic MSH2 P43246 N311A 311 N A 0.78 Pathogenic MSH2 P43246 N311C 311 N C 0.73 Pathogenic MSH2 P43246 N311D 311 N D 0.456 Neutral MSH2 P43246 N311E 311 N E 0.546 Pathogenic MSH2 P43246 N311F 311 N F 0.946 Pathogenic MSH2 P43246 N311G 311 N G 0.222 Neutral MSH2 P43246 N311H 311 N H 0.408 Neutral MSH2 P43246 N311I 311 N I 0.932 Pathogenic MSH2 P43246 N311K 311 N K 0.762 Pathogenic MSH2 P43246 N311L 311 N L 0.94 Pathogenic MSH2 P43246 N311M 311 N M 0.942 Pathogenic MSH2 P43246 N311P 311 N P 0.834 Pathogenic MSH2 P43246 N311Q 311 N Q 0.73 Pathogenic MSH2 P43246 N311R 311 N R 0.942 Pathogenic MSH2 P43246 N311S 311 N S 0.172 Neutral MSH2 P43246 N311T 311 N T 0.358 Neutral MSH2 P43246 N311V 311 N V 0.974 Pathogenic MSH2 P43246 N311W 311 N W 0.962 Pathogenic MSH2 P43246 N311Y 311 N Y 0.956 Pathogenic MSH2 P43246 L312A 312 L A 0.698 Pathogenic MSH2 P43246 L312C 312 L C 0.816 Pathogenic MSH2 P43246 L312D 312 L D 0.896 Pathogenic MSH2 P43246 L312E 312 L E 0.876 Pathogenic MSH2 P43246 L312F 312 L F 0.956 Pathogenic MSH2 P43246 L312G 312 L G 0.814 Pathogenic MSH2 P43246 L312H 312 L H 0.906 Pathogenic MSH2 P43246 L312I 312 L I 0.216 Neutral MSH2 P43246 L312K 312 L K 0.75 Pathogenic MSH2 P43246 L312M 312 L M 0.402 Neutral MSH2 P43246 L312N 312 L N 0.766 Pathogenic MSH2 P43246 L312P 312 L P 0.992 Pathogenic MSH2 P43246 L312Q 312 L Q 0.734 Pathogenic MSH2 P43246 L312R 312 L R 0.984 Pathogenic MSH2 P43246 L312S 312 L S 0.318 Neutral MSH2 P43246 L312T 312 L T 0.606 Pathogenic MSH2 P43246 L312V 312 L V 0.046 Neutral MSH2 P43246 L312W 312 L W 0.928 Pathogenic MSH2 P43246 L312Y 312 L Y 0.894 Pathogenic MSH2 P43246 F313A 313 F A 0.158 Neutral MSH2 P43246 F313C 313 F C 0.15 Neutral MSH2 P43246 F313D 313 F D 0.486 Neutral MSH2 P43246 F313E 313 F E 0.1 Neutral MSH2 P43246 F313G 313 F G 0.36 Neutral MSH2 P43246 F313H 313 F H 0.334 Neutral MSH2 P43246 F313I 313 F I 0.07 Neutral MSH2 P43246 F313K 313 F K 0.618 Pathogenic MSH2 P43246 F313L 313 F L 0.02 Neutral MSH2 P43246 F313M 313 F M 0.032 Neutral MSH2 P43246 F313N 313 F N 0.56 Pathogenic MSH2 P43246 F313P 313 F P 0.76 Pathogenic MSH2 P43246 F313Q 313 F Q 0.592 Pathogenic MSH2 P43246 F313R 313 F R 0.642 Pathogenic MSH2 P43246 F313S 313 F S 0.418 Neutral MSH2 P43246 F313T 313 F T 0.048 Neutral MSH2 P43246 F313V 313 F V 0.042 Neutral MSH2 P43246 F313W 313 F W 0.866 Pathogenic MSH2 P43246 F313Y 313 F Y 0.562 Pathogenic MSH2 P43246 Q314A 314 Q A 0.228 Neutral MSH2 P43246 Q314C 314 Q C 0.492 Neutral MSH2 P43246 Q314D 314 Q D 0.248 Neutral MSH2 P43246 Q314E 314 Q E 0.016 Neutral MSH2 P43246 Q314F 314 Q F 0.846 Pathogenic MSH2 P43246 Q314G 314 Q G 0.456 Neutral MSH2 P43246 Q314H 314 Q H 0.808 Pathogenic MSH2 P43246 Q314I 314 Q I 0.848 Pathogenic MSH2 P43246 Q314K 314 Q K 0.354 Neutral MSH2 P43246 Q314L 314 Q L 0.754 Pathogenic MSH2 P43246 Q314M 314 Q M 0.738 Pathogenic MSH2 P43246 Q314N 314 Q N 0.604 Pathogenic MSH2 P43246 Q314P 314 Q P 0.456 Neutral MSH2 P43246 Q314R 314 Q R 0.596 Pathogenic MSH2 P43246 Q314S 314 Q S 0.098 Neutral MSH2 P43246 Q314T 314 Q T 0.434 Neutral MSH2 P43246 Q314V 314 Q V 0.844 Pathogenic MSH2 P43246 Q314W 314 Q W 0.92 Pathogenic MSH2 P43246 Q314Y 314 Q Y 0.89 Pathogenic MSH2 P43246 G315A 315 G A 0.048 Neutral MSH2 P43246 G315C 315 G C 0.612 Pathogenic MSH2 P43246 G315D 315 G D 0.46 Neutral MSH2 P43246 G315E 315 G E 0.44 Neutral MSH2 P43246 G315F 315 G F 0.908 Pathogenic MSH2 P43246 G315H 315 G H 0.876 Pathogenic MSH2 P43246 G315I 315 G I 0.89 Pathogenic MSH2 P43246 G315K 315 G K 0.52 Pathogenic MSH2 P43246 G315L 315 G L 0.696 Pathogenic MSH2 P43246 G315M 315 G M 0.898 Pathogenic MSH2 P43246 G315N 315 G N 0.396 Neutral MSH2 P43246 G315P 315 G P 0.878 Pathogenic MSH2 P43246 G315Q 315 G Q 0.442 Neutral MSH2 P43246 G315R 315 G R 0.522 Pathogenic MSH2 P43246 G315S 315 G S 0.074 Neutral MSH2 P43246 G315T 315 G T 0.492 Neutral MSH2 P43246 G315V 315 G V 0.696 Pathogenic MSH2 P43246 G315W 315 G W 0.904 Pathogenic MSH2 P43246 G315Y 315 G Y 0.896 Pathogenic MSH2 P43246 S316A 316 S A 0.028 Neutral MSH2 P43246 S316C 316 S C 0.334 Neutral MSH2 P43246 S316D 316 S D 0.358 Neutral MSH2 P43246 S316E 316 S E 0.592 Pathogenic MSH2 P43246 S316F 316 S F 0.76 Pathogenic MSH2 P43246 S316G 316 S G 0.036 Neutral MSH2 P43246 S316H 316 S H 0.688 Pathogenic MSH2 P43246 S316I 316 S I 0.412 Neutral MSH2 P43246 S316K 316 S K 0.48 Neutral MSH2 P43246 S316L 316 S L 0.464 Neutral MSH2 P43246 S316M 316 S M 0.894 Pathogenic MSH2 P43246 S316N 316 S N 0.222 Neutral MSH2 P43246 S316P 316 S P 0.118 Neutral MSH2 P43246 S316Q 316 S Q 0.526 Pathogenic MSH2 P43246 S316R 316 S R 0.394 Neutral MSH2 P43246 S316T 316 S T 0.146 Neutral MSH2 P43246 S316V 316 S V 0.078 Neutral MSH2 P43246 S316W 316 S W 0.906 Pathogenic MSH2 P43246 S316Y 316 S Y 0.88 Pathogenic MSH2 P43246 V317A 317 V A 0 Neutral MSH2 P43246 V317C 317 V C 0.058 Neutral MSH2 P43246 V317D 317 V D 0.028 Neutral MSH2 P43246 V317E 317 V E 0.098 Neutral MSH2 P43246 V317F 317 V F 0.15 Neutral MSH2 P43246 V317G 317 V G 0.038 Neutral MSH2 P43246 V317H 317 V H 0.112 Neutral MSH2 P43246 V317I 317 V I 0.06 Neutral MSH2 P43246 V317K 317 V K 0.158 Neutral MSH2 P43246 V317L 317 V L 0 Neutral MSH2 P43246 V317M 317 V M 0.014 Neutral MSH2 P43246 V317N 317 V N 0.038 Neutral MSH2 P43246 V317P 317 V P 0.036 Neutral MSH2 P43246 V317Q 317 V Q 0.216 Neutral MSH2 P43246 V317R 317 V R 0.274 Neutral MSH2 P43246 V317S 317 V S 0.01 Neutral MSH2 P43246 V317T 317 V T 0.008 Neutral MSH2 P43246 V317W 317 V W 0.344 Neutral MSH2 P43246 V317Y 317 V Y 0.256 Neutral MSH2 P43246 E318A 318 E A 0.08 Neutral MSH2 P43246 E318C 318 E C 0.11 Neutral MSH2 P43246 E318D 318 E D 0.002 Neutral MSH2 P43246 E318F 318 E F 0.436 Neutral MSH2 P43246 E318G 318 E G 0.002 Neutral MSH2 P43246 E318H 318 E H 0.246 Neutral MSH2 P43246 E318I 318 E I 0.46 Neutral MSH2 P43246 E318K 318 E K 0.29 Neutral MSH2 P43246 E318L 318 E L 0.458 Neutral MSH2 P43246 E318M 318 E M 0.298 Neutral MSH2 P43246 E318N 318 E N 0.054 Neutral MSH2 P43246 E318P 318 E P 0.062 Neutral MSH2 P43246 E318Q 318 E Q 0.02 Neutral MSH2 P43246 E318R 318 E R 0.098 Neutral MSH2 P43246 E318S 318 E S 0.016 Neutral MSH2 P43246 E318T 318 E T 0.01 Neutral MSH2 P43246 E318V 318 E V 0.058 Neutral MSH2 P43246 E318W 318 E W 0.708 Pathogenic MSH2 P43246 E318Y 318 E Y 0.658 Pathogenic MSH2 P43246 D319A 319 D A 0.014 Neutral MSH2 P43246 D319C 319 D C 0.17 Neutral MSH2 P43246 D319E 319 D E 0.014 Neutral MSH2 P43246 D319F 319 D F 0.528 Pathogenic MSH2 P43246 D319G 319 D G 0.018 Neutral MSH2 P43246 D319H 319 D H 0.11 Neutral MSH2 P43246 D319I 319 D I 0.322 Neutral MSH2 P43246 D319K 319 D K 0.21 Neutral MSH2 P43246 D319L 319 D L 0.316 Neutral MSH2 P43246 D319M 319 D M 0.236 Neutral MSH2 P43246 D319N 319 D N 0 Neutral MSH2 P43246 D319P 319 D P 0.164 Neutral MSH2 P43246 D319Q 319 D Q 0.016 Neutral MSH2 P43246 D319R 319 D R 0.234 Neutral MSH2 P43246 D319S 319 D S 0.076 Neutral MSH2 P43246 D319T 319 D T 0.106 Neutral MSH2 P43246 D319V 319 D V 0.208 Neutral MSH2 P43246 D319W 319 D W 0.552 Pathogenic MSH2 P43246 D319Y 319 D Y 0.522 Pathogenic MSH2 P43246 T32A 32 T A 0.142 Neutral MSH2 P43246 T32C 32 T C 0.124 Neutral MSH2 P43246 T32D 32 T D 0.03 Neutral MSH2 P43246 T32E 32 T E 0.038 Neutral MSH2 P43246 T32F 32 T F 0.456 Neutral MSH2 P43246 T32G 32 T G 0.002 Neutral MSH2 P43246 T32H 32 T H 0.232 Neutral MSH2 P43246 T32I 32 T I 0.202 Neutral MSH2 P43246 T32K 32 T K 0.142 Neutral MSH2 P43246 T32L 32 T L 0.188 Neutral MSH2 P43246 T32M 32 T M 0.292 Neutral MSH2 P43246 T32N 32 T N 0 Neutral MSH2 P43246 T32P 32 T P 0.244 Neutral MSH2 P43246 T32Q 32 T Q 0.004 Neutral MSH2 P43246 T32R 32 T R 0.39 Neutral MSH2 P43246 T32S 32 T S 0 Neutral MSH2 P43246 T32V 32 T V 0.354 Neutral MSH2 P43246 T32W 32 T W 0.756 Pathogenic MSH2 P43246 T32Y 32 T Y 0.716 Pathogenic MSH2 P43246 T320A 320 T A 0.002 Neutral MSH2 P43246 T320C 320 T C 0.064 Neutral MSH2 P43246 T320D 320 T D 0.02 Neutral MSH2 P43246 T320E 320 T E 0.078 Neutral MSH2 P43246 T320F 320 T F 0.258 Neutral MSH2 P43246 T320G 320 T G 0.002 Neutral MSH2 P43246 T320H 320 T H 0.12 Neutral MSH2 P43246 T320I 320 T I 0.084 Neutral MSH2 P43246 T320K 320 T K 0.028 Neutral MSH2 P43246 T320L 320 T L 0.02 Neutral MSH2 P43246 T320M 320 T M 0.142 Neutral MSH2 P43246 T320N 320 T N 0.012 Neutral MSH2 P43246 T320P 320 T P 0.018 Neutral MSH2 P43246 T320Q 320 T Q 0.012 Neutral MSH2 P43246 T320R 320 T R 0.312 Neutral MSH2 P43246 T320S 320 T S 0 Neutral MSH2 P43246 T320V 320 T V 0.096 Neutral MSH2 P43246 T320W 320 T W 0.536 Pathogenic MSH2 P43246 T320Y 320 T Y 0.492 Neutral MSH2 P43246 T321A 321 T A 0 Neutral MSH2 P43246 T321C 321 T C 0.064 Neutral MSH2 P43246 T321D 321 T D 0.058 Neutral MSH2 P43246 T321E 321 T E 0.062 Neutral MSH2 P43246 T321F 321 T F 0.182 Neutral MSH2 P43246 T321G 321 T G 0.002 Neutral MSH2 P43246 T321H 321 T H 0.062 Neutral MSH2 P43246 T321I 321 T I 0.042 Neutral MSH2 P43246 T321K 321 T K 0.042 Neutral MSH2 P43246 T321L 321 T L 0.074 Neutral MSH2 P43246 T321M 321 T M 0.102 Neutral MSH2 P43246 T321N 321 T N 0 Neutral MSH2 P43246 T321P 321 T P 0.008 Neutral MSH2 P43246 T321Q 321 T Q 0 Neutral MSH2 P43246 T321R 321 T R 0.264 Neutral MSH2 P43246 T321S 321 T S 0 Neutral MSH2 P43246 T321V 321 T V 0.046 Neutral MSH2 P43246 T321W 321 T W 0.476 Neutral MSH2 P43246 T321Y 321 T Y 0.434 Neutral MSH2 P43246 G322A 322 G A 0.004 Neutral MSH2 P43246 G322C 322 G C 0.164 Neutral MSH2 P43246 G322D 322 G D 0.126 Neutral 1 MSH2 P43246 G322E 322 G E 0.226 Neutral MSH2 P43246 G322F 322 G F 0.546 Pathogenic MSH2 P43246 G322H 322 G H 0.358 Neutral MSH2 P43246 G322I 322 G I 0.458 Neutral MSH2 P43246 G322K 322 G K 0.308 Neutral MSH2 P43246 G322L 322 G L 0.402 Neutral MSH2 P43246 G322M 322 G M 0.4 Neutral MSH2 P43246 G322N 322 G N 0.19 Neutral MSH2 P43246 G322P 322 G P 0.426 Neutral MSH2 P43246 G322Q 322 G Q 0.224 Neutral MSH2 P43246 G322R 322 G R 0.424 Neutral MSH2 P43246 G322S 322 G S 0.018 Neutral MSH2 P43246 G322T 322 G T 0.284 Neutral MSH2 P43246 G322V 322 G V 0.328 Neutral MSH2 P43246 G322W 322 G W 0.544 Pathogenic MSH2 P43246 G322Y 322 G Y 0.54 Pathogenic MSH2 P43246 S323A 323 S A 0.016 Neutral MSH2 P43246 S323C 323 S C 0.032 Neutral MSH2 P43246 S323D 323 S D 0.01 Neutral MSH2 P43246 S323E 323 S E 0.388 Neutral MSH2 P43246 S323F 323 S F 0.506 Pathogenic MSH2 P43246 S323G 323 S G 0.012 Neutral MSH2 P43246 S323H 323 S H 0.474 Neutral MSH2 P43246 S323I 323 S I 0.234 Neutral MSH2 P43246 S323K 323 S K 0.422 Neutral MSH2 P43246 S323L 323 S L 0.164 Neutral MSH2 P43246 S323M 323 S M 0.688 Pathogenic MSH2 P43246 S323N 323 S N 0.008 Neutral MSH2 P43246 S323P 323 S P 0.074 Neutral MSH2 P43246 S323Q 323 S Q 0.34 Neutral MSH2 P43246 S323R 323 S R 0.324 Neutral MSH2 P43246 S323T 323 S T 0.022 Neutral MSH2 P43246 S323V 323 S V 0.056 Neutral MSH2 P43246 S323W 323 S W 0.83 Pathogenic MSH2 P43246 S323Y 323 S Y 0.794 Pathogenic MSH2 P43246 Q324A 324 Q A 0.242 Neutral MSH2 P43246 Q324C 324 Q C 0.422 Neutral MSH2 P43246 Q324D 324 Q D 0.038 Neutral MSH2 P43246 Q324E 324 Q E 0.6 Pathogenic MSH2 P43246 Q324F 324 Q F 0.78 Pathogenic MSH2 P43246 Q324G 324 Q G 0.098 Neutral MSH2 P43246 Q324H 324 Q H 0.07 Neutral MSH2 P43246 Q324I 324 Q I 0.572 Pathogenic MSH2 P43246 Q324K 324 Q K 0.184 Neutral MSH2 P43246 Q324L 324 Q L 0.792 Pathogenic MSH2 P43246 Q324M 324 Q M 0.078 Neutral MSH2 P43246 Q324N 324 Q N 0.08 Neutral MSH2 P43246 Q324P 324 Q P 0.838 Pathogenic MSH2 P43246 Q324R 324 Q R 0.282 Neutral MSH2 P43246 Q324S 324 Q S 0.084 Neutral MSH2 P43246 Q324T 324 Q T 0.028 Neutral MSH2 P43246 Q324V 324 Q V 0.786 Pathogenic MSH2 P43246 Q324W 324 Q W 0.896 Pathogenic MSH2 P43246 Q324Y 324 Q Y 0.908 Pathogenic MSH2 P43246 S325A 325 S A 0.044 Neutral MSH2 P43246 S325C 325 S C 0.08 Neutral MSH2 P43246 S325D 325 S D 0.374 Neutral MSH2 P43246 S325E 325 S E 0.628 Pathogenic MSH2 P43246 S325F 325 S F 0.796 Pathogenic MSH2 P43246 S325G 325 S G 0.024 Neutral MSH2 P43246 S325H 325 S H 0.804 Pathogenic MSH2 P43246 S325I 325 S I 0.466 Neutral MSH2 P43246 S325K 325 S K 0.544 Pathogenic MSH2 P43246 S325L 325 S L 0.17 Neutral MSH2 P43246 S325M 325 S M 0.592 Pathogenic MSH2 P43246 S325N 325 S N 0.062 Neutral MSH2 P43246 S325P 325 S P 0.35 Neutral MSH2 P43246 S325Q 325 S Q 0.476 Neutral MSH2 P43246 S325R 325 S R 0.684 Pathogenic MSH2 P43246 S325T 325 S T 0.09 Neutral MSH2 P43246 S325V 325 S V 0.132 Neutral MSH2 P43246 S325W 325 S W 0.952 Pathogenic MSH2 P43246 S325Y 325 S Y 0.934 Pathogenic MSH2 P43246 L326A 326 L A 0.04 Neutral MSH2 P43246 L326C 326 L C 0.294 Neutral MSH2 P43246 L326D 326 L D 0.568 Pathogenic MSH2 P43246 L326E 326 L E 0.534 Pathogenic MSH2 P43246 L326F 326 L F 0.73 Pathogenic MSH2 P43246 L326G 326 L G 0.112 Neutral MSH2 P43246 L326H 326 L H 0.022 Neutral MSH2 P43246 L326I 326 L I 0.064 Neutral MSH2 P43246 L326K 326 L K 0.036 Neutral MSH2 P43246 L326M 326 L M 0.21 Neutral MSH2 P43246 L326N 326 L N 0.088 Neutral MSH2 P43246 L326P 326 L P 0.174 Neutral MSH2 P43246 L326Q 326 L Q 0.142 Neutral MSH2 P43246 L326R 326 L R 0.756 Pathogenic MSH2 P43246 L326S 326 L S 0.046 Neutral MSH2 P43246 L326T 326 L T 0.048 Neutral MSH2 P43246 L326V 326 L V 0.012 Neutral MSH2 P43246 L326W 326 L W 0.822 Pathogenic MSH2 P43246 L326Y 326 L Y 0.814 Pathogenic MSH2 P43246 A327C 327 A C 0.734 Pathogenic MSH2 P43246 A327D 327 A D 0.864 Pathogenic MSH2 P43246 A327E 327 A E 0.864 Pathogenic MSH2 P43246 A327F 327 A F 0.616 Pathogenic MSH2 P43246 A327G 327 A G 0.022 Neutral MSH2 P43246 A327H 327 A H 0.796 Pathogenic MSH2 P43246 A327I 327 A I 0.92 Pathogenic MSH2 P43246 A327K 327 A K 0.614 Pathogenic MSH2 P43246 A327L 327 A L 0.582 Pathogenic MSH2 P43246 A327M 327 A M 0.788 Pathogenic MSH2 P43246 A327N 327 A N 0.728 Pathogenic MSH2 P43246 A327P 327 A P 0.174 Neutral MSH2 P43246 A327Q 327 A Q 0.706 Pathogenic MSH2 P43246 A327R 327 A R 0.63 Pathogenic MSH2 P43246 A327S 327 A S 0.01 Neutral MSH2 P43246 A327T 327 A T 0.044 Neutral MSH2 P43246 A327V 327 A V 0.242 Neutral MSH2 P43246 A327W 327 A W 0.95 Pathogenic MSH2 P43246 A327Y 327 A Y 0.934 Pathogenic MSH2 P43246 A328C 328 A C 0.686 Pathogenic MSH2 P43246 A328D 328 A D 0.792 Pathogenic MSH2 P43246 A328E 328 A E 0.884 Pathogenic MSH2 P43246 A328F 328 A F 0.922 Pathogenic MSH2 P43246 A328G 328 A G 0.024 Neutral MSH2 P43246 A328H 328 A H 0.842 Pathogenic MSH2 P43246 A328I 328 A I 0.624 Pathogenic MSH2 P43246 A328K 328 A K 0.916 Pathogenic MSH2 P43246 A328L 328 A L 0.948 Pathogenic MSH2 P43246 A328M 328 A M 0.838 Pathogenic MSH2 P43246 A328N 328 A N 0.584 Pathogenic MSH2 P43246 A328P 328 A P 0.872 Pathogenic MSH2 P43246 A328Q 328 A Q 0.796 Pathogenic MSH2 P43246 A328R 328 A R 0.926 Pathogenic MSH2 P43246 A328S 328 A S 0.016 Neutral MSH2 P43246 A328T 328 A T 0.052 Neutral MSH2 P43246 A328V 328 A V 0.146 Neutral MSH2 P43246 A328W 328 A W 0.954 Pathogenic MSH2 P43246 A328Y 328 A Y 0.624 Pathogenic MSH2 P43246 L329A 329 L A 0.702 Pathogenic MSH2 P43246 L329C 329 L C 0.806 Pathogenic MSH2 P43246 L329D 329 L D 0.884 Pathogenic MSH2 P43246 L329E 329 L E 0.866 Pathogenic MSH2 P43246 L329F 329 L F 0.664 Pathogenic MSH2 P43246 L329G 329 L G 0.858 Pathogenic MSH2 P43246 L329H 329 L H 0.898 Pathogenic MSH2 P43246 L329I 329 L I 0.298 Neutral MSH2 P43246 L329K 329 L K 0.69 Pathogenic MSH2 P43246 L329M 329 L M 0.342 Neutral MSH2 P43246 L329N 329 L N 0.796 Pathogenic MSH2 P43246 L329P 329 L P 0.966 Pathogenic MSH2 P43246 L329Q 329 L Q 0.756 Pathogenic MSH2 P43246 L329R 329 L R 0.974 Pathogenic MSH2 P43246 L329S 329 L S 0.68 Pathogenic MSH2 P43246 L329T 329 L T 0.598 Pathogenic MSH2 P43246 L329V 329 L V 0.068 Neutral MSH2 P43246 L329W 329 L W 0.846 Pathogenic MSH2 P43246 L329Y 329 L Y 0.868 Pathogenic MSH2 P43246 T33A 33 T A 0.332 Neutral MSH2 P43246 T33C 33 T C 0.498 Neutral MSH2 P43246 T33D 33 T D 0.144 Neutral MSH2 P43246 T33E 33 T E 0.622 Pathogenic MSH2 P43246 T33F 33 T F 0.748 Pathogenic MSH2 P43246 T33G 33 T G 0.298 Neutral MSH2 P43246 T33H 33 T H 0.592 Pathogenic MSH2 P43246 T33I 33 T I 0.544 Pathogenic MSH2 P43246 T33K 33 T K 0.544 Pathogenic MSH2 P43246 T33L 33 T L 0.55 Pathogenic MSH2 P43246 T33M 33 T M 0.394 Neutral MSH2 P43246 T33N 33 T N 0.124 Neutral MSH2 P43246 T33P 33 T P 0.638 Pathogenic MSH2 P43246 T33Q 33 T Q 0.362 Neutral MSH2 P43246 T33R 33 T R 0.838 Pathogenic MSH2 P43246 T33S 33 T S 0.18 Neutral MSH2 P43246 T33V 33 T V 0.736 Pathogenic MSH2 P43246 T33W 33 T W 0.946 Pathogenic MSH2 P43246 T33Y 33 T Y 0.942 Pathogenic MSH2 P43246 L330A 330 L A 0.714 Pathogenic MSH2 P43246 L330C 330 L C 0.822 Pathogenic MSH2 P43246 L330D 330 L D 0.91 Pathogenic MSH2 P43246 L330E 330 L E 0.896 Pathogenic MSH2 P43246 L330F 330 L F 0.872 Pathogenic MSH2 P43246 L330G 330 L G 0.864 Pathogenic MSH2 P43246 L330H 330 L H 0.91 Pathogenic MSH2 P43246 L330I 330 L I 0.934 Pathogenic MSH2 P43246 L330K 330 L K 0.728 Pathogenic MSH2 P43246 L330M 330 L M 0.328 Neutral MSH2 P43246 L330N 330 L N 0.82 Pathogenic MSH2 P43246 L330P 330 L P 0.85 Pathogenic 4 MSH2 P43246 L330Q 330 L Q 0.776 Pathogenic MSH2 P43246 L330R 330 L R 0.986 Pathogenic MSH2 P43246 L330S 330 L S 0.706 Pathogenic MSH2 P43246 L330T 330 L T 0.626 Pathogenic MSH2 P43246 L330V 330 L V 0.424 Neutral MSH2 P43246 L330W 330 L W 0.878 Pathogenic MSH2 P43246 L330Y 330 L Y 0.89 Pathogenic MSH2 P43246 N331A 331 N A 0.78 Pathogenic MSH2 P43246 N331C 331 N C 0.732 Pathogenic MSH2 P43246 N331D 331 N D 0.158 Neutral 2 MSH2 P43246 N331E 331 N E 0.548 Pathogenic MSH2 P43246 N331F 331 N F 0.946 Pathogenic MSH2 P43246 N331G 331 N G 0.682 Pathogenic MSH2 P43246 N331H 331 N H 0.83 Pathogenic MSH2 P43246 N331I 331 N I 0.932 Pathogenic MSH2 P43246 N331K 331 N K 0.882 Pathogenic MSH2 P43246 N331L 331 N L 0.74 Pathogenic MSH2 P43246 N331M 331 N M 0.942 Pathogenic MSH2 P43246 N331P 331 N P 0.836 Pathogenic MSH2 P43246 N331Q 331 N Q 0.734 Pathogenic MSH2 P43246 N331R 331 N R 0.942 Pathogenic MSH2 P43246 N331S 331 N S 0.66 Pathogenic MSH2 P43246 N331T 331 N T 0.358 Neutral MSH2 P43246 N331V 331 N V 0.75 Pathogenic MSH2 P43246 N331W 331 N W 0.962 Pathogenic MSH2 P43246 N331Y 331 N Y 0.956 Pathogenic MSH2 P43246 K332A 332 K A 0.486 Neutral MSH2 P43246 K332C 332 K C 0.404 Neutral MSH2 P43246 K332D 332 K D 0.564 Pathogenic MSH2 P43246 K332E 332 K E 0.236 Neutral MSH2 P43246 K332F 332 K F 0.88 Pathogenic MSH2 P43246 K332G 332 K G 0.314 Neutral MSH2 P43246 K332H 332 K H 0.046 Neutral MSH2 P43246 K332I 332 K I 0.96 Pathogenic MSH2 P43246 K332L 332 K L 0.942 Pathogenic MSH2 P43246 K332M 332 K M 0.244 Neutral MSH2 P43246 K332N 332 K N 0.098 Neutral MSH2 P43246 K332P 332 K P 0.85 Pathogenic MSH2 P43246 K332Q 332 K Q 0.1 Neutral MSH2 P43246 K332R 332 K R 0.126 Neutral MSH2 P43246 K332S 332 K S 0.358 Neutral MSH2 P43246 K332T 332 K T 0.49 Neutral MSH2 P43246 K332V 332 K V 0.798 Pathogenic MSH2 P43246 K332W 332 K W 0.966 Pathogenic MSH2 P43246 K332Y 332 K Y 0.68 Pathogenic MSH2 P43246 C333A 333 C A 0.46 Neutral MSH2 P43246 C333D 333 C D 0.96 Pathogenic MSH2 P43246 C333E 333 C E 0.834 Pathogenic MSH2 P43246 C333F 333 C F 0.966 Pathogenic MSH2 P43246 C333G 333 C G 0.546 Pathogenic MSH2 P43246 C333H 333 C H 0.798 Pathogenic MSH2 P43246 C333I 333 C I 0.946 Pathogenic MSH2 P43246 C333K 333 C K 0.874 Pathogenic MSH2 P43246 C333L 333 C L 0.832 Pathogenic MSH2 P43246 C333M 333 C M 0.696 Pathogenic MSH2 P43246 C333N 333 C N 0.828 Pathogenic MSH2 P43246 C333P 333 C P 0.968 Pathogenic MSH2 P43246 C333Q 333 C Q 0.58 Pathogenic MSH2 P43246 C333R 333 C R 0.74 Pathogenic MSH2 P43246 C333S 333 C S 0.374 Neutral MSH2 P43246 C333T 333 C T 0.4 Neutral MSH2 P43246 C333V 333 C V 0.95 Pathogenic MSH2 P43246 C333W 333 C W 0.976 Pathogenic MSH2 P43246 C333Y 333 C Y 0.962 Pathogenic MSH2 P43246 K334A 334 K A 0.54 Pathogenic MSH2 P43246 K334C 334 K C 0.09 Neutral MSH2 P43246 K334D 334 K D 0.604 Pathogenic MSH2 P43246 K334E 334 K E 0.714 Pathogenic MSH2 P43246 K334F 334 K F 0.964 Pathogenic MSH2 P43246 K334G 334 K G 0.54 Pathogenic MSH2 P43246 K334H 334 K H 0.736 Pathogenic MSH2 P43246 K334I 334 K I 0.988 Pathogenic MSH2 P43246 K334L 334 K L 0.978 Pathogenic MSH2 P43246 K334M 334 K M 0.922 Pathogenic MSH2 P43246 K334N 334 K N 0.1 Neutral MSH2 P43246 K334P 334 K P 0.922 Pathogenic MSH2 P43246 K334Q 334 K Q 0.102 Neutral MSH2 P43246 K334R 334 K R 0.098 Neutral MSH2 P43246 K334S 334 K S 0.718 Pathogenic MSH2 P43246 K334T 334 K T 0.126 Neutral MSH2 P43246 K334V 334 K V 0.522 Pathogenic MSH2 P43246 K334W 334 K W 0.992 Pathogenic MSH2 P43246 K334Y 334 K Y 0.984 Pathogenic MSH2 P43246 T335A 335 T A 0.232 Neutral MSH2 P43246 T335C 335 T C 0.916 Pathogenic MSH2 P43246 T335D 335 T D 0.924 Pathogenic MSH2 P43246 T335E 335 T E 0.93 Pathogenic MSH2 P43246 T335F 335 T F 0.942 Pathogenic MSH2 P43246 T335G 335 T G 0.73 Pathogenic MSH2 P43246 T335H 335 T H 0.91 Pathogenic MSH2 P43246 T335I 335 T I 0.938 Pathogenic MSH2 P43246 T335K 335 T K 0.928 Pathogenic MSH2 P43246 T335L 335 T L 0.934 Pathogenic MSH2 P43246 T335M 335 T M 0.968 Pathogenic MSH2 P43246 T335N 335 T N 0.416 Neutral MSH2 P43246 T335P 335 T P 0.488 Neutral MSH2 P43246 T335Q 335 T Q 0.444 Neutral MSH2 P43246 T335R 335 T R 0.988 Pathogenic MSH2 P43246 T335S 335 T S 0.272 Neutral MSH2 P43246 T335V 335 T V 0.458 Neutral MSH2 P43246 T335W 335 T W 0.948 Pathogenic MSH2 P43246 T335Y 335 T Y 0.948 Pathogenic MSH2 P43246 P336A 336 P A 0.076 Neutral MSH2 P43246 P336C 336 P C 0.642 Pathogenic MSH2 P43246 P336D 336 P D 0.484 Neutral MSH2 P43246 P336E 336 P E 0.738 Pathogenic MSH2 P43246 P336F 336 P F 0.942 Pathogenic MSH2 P43246 P336G 336 P G 0.052 Neutral MSH2 P43246 P336H 336 P H 0.592 Pathogenic MSH2 P43246 P336I 336 P I 0.334 Neutral MSH2 P43246 P336K 336 P K 0.698 Pathogenic MSH2 P43246 P336L 336 P L 0.178 Neutral MSH2 P43246 P336M 336 P M 0.734 Pathogenic MSH2 P43246 P336N 336 P N 0.04 Neutral MSH2 P43246 P336Q 336 P Q 0.502 Pathogenic MSH2 P43246 P336R 336 P R 0.86 Pathogenic MSH2 P43246 P336S 336 P S 0.018 Neutral MSH2 P43246 P336T 336 P T 0.386 Neutral MSH2 P43246 P336V 336 P V 0.078 Neutral MSH2 P43246 P336W 336 P W 0.878 Pathogenic MSH2 P43246 P336Y 336 P Y 0.852 Pathogenic MSH2 P43246 Q337A 337 Q A 0.236 Neutral MSH2 P43246 Q337C 337 Q C 0.592 Pathogenic MSH2 P43246 Q337D 337 Q D 0.648 Pathogenic MSH2 P43246 Q337E 337 Q E 0.588 Pathogenic MSH2 P43246 Q337F 337 Q F 0.8 Pathogenic MSH2 P43246 Q337G 337 Q G 0.222 Neutral MSH2 P43246 Q337H 337 Q H 0.52 Pathogenic MSH2 P43246 Q337I 337 Q I 0.504 Pathogenic MSH2 P43246 Q337K 337 Q K 0.78 Pathogenic MSH2 P43246 Q337L 337 Q L 0.418 Neutral MSH2 P43246 Q337M 337 Q M 0.26 Neutral MSH2 P43246 Q337N 337 Q N 0.334 Neutral MSH2 P43246 Q337P 337 Q P 0.73 Pathogenic MSH2 P43246 Q337R 337 Q R 0.478 Neutral MSH2 P43246 Q337S 337 Q S 0.426 Neutral MSH2 P43246 Q337T 337 Q T 0.186 Neutral MSH2 P43246 Q337V 337 Q V 0.3 Neutral MSH2 P43246 Q337W 337 Q W 0.862 Pathogenic MSH2 P43246 Q337Y 337 Q Y 0.846 Pathogenic MSH2 P43246 G338A 338 G A 0.768 Pathogenic MSH2 P43246 G338C 338 G C 0.948 Pathogenic MSH2 P43246 G338D 338 G D 0.804 Pathogenic MSH2 P43246 G338E 338 G E 0.988 Pathogenic 5 MSH2 P43246 G338F 338 G F 0.984 Pathogenic MSH2 P43246 G338H 338 G H 0.988 Pathogenic MSH2 P43246 G338I 338 G I 0.974 Pathogenic MSH2 P43246 G338K 338 G K 0.988 Pathogenic MSH2 P43246 G338L 338 G L 0.984 Pathogenic MSH2 P43246 G338M 338 G M 0.994 Pathogenic MSH2 P43246 G338N 338 G N 0.986 Pathogenic MSH2 P43246 G338P 338 G P 0.966 Pathogenic MSH2 P43246 G338Q 338 G Q 0.994 Pathogenic MSH2 P43246 G338R 338 G R 1 Pathogenic MSH2 P43246 G338S 338 G S 0.832 Pathogenic MSH2 P43246 G338T 338 G T 0.846 Pathogenic MSH2 P43246 G338V 338 G V 0.986 Pathogenic MSH2 P43246 G338W 338 G W 0.98 Pathogenic MSH2 P43246 G338Y 338 G Y 0.96 Pathogenic MSH2 P43246 Q339A 339 Q A 0.236 Neutral MSH2 P43246 Q339C 339 Q C 0.438 Neutral MSH2 P43246 Q339D 339 Q D 0.482 Neutral MSH2 P43246 Q339E 339 Q E 0.564 Pathogenic MSH2 P43246 Q339F 339 Q F 0.818 Pathogenic MSH2 P43246 Q339G 339 Q G 0.118 Neutral MSH2 P43246 Q339H 339 Q H 0.078 Neutral MSH2 P43246 Q339I 339 Q I 0.44 Neutral MSH2 P43246 Q339K 339 Q K 0.058 Neutral MSH2 P43246 Q339L 339 Q L 0.748 Pathogenic MSH2 P43246 Q339M 339 Q M 0.202 Neutral MSH2 P43246 Q339N 339 Q N 0.526 Pathogenic MSH2 P43246 Q339P 339 Q P 0.834 Pathogenic MSH2 P43246 Q339R 339 Q R 0.082 Neutral MSH2 P43246 Q339S 339 Q S 0.096 Neutral MSH2 P43246 Q339T 339 Q T 0.028 Neutral MSH2 P43246 Q339V 339 Q V 0.104 Neutral MSH2 P43246 Q339W 339 Q W 0.93 Pathogenic MSH2 P43246 Q339Y 339 Q Y 0.892 Pathogenic MSH2 P43246 V34A 34 V A 0.212 Neutral MSH2 P43246 V34C 34 V C 0.524 Pathogenic MSH2 P43246 V34D 34 V D 0.722 Pathogenic MSH2 P43246 V34E 34 V E 0.834 Pathogenic MSH2 P43246 V34F 34 V F 0.528 Pathogenic MSH2 P43246 V34G 34 V G 0.754 Pathogenic MSH2 P43246 V34H 34 V H 0.67 Pathogenic MSH2 P43246 V34I 34 V I 0.148 Neutral MSH2 P43246 V34K 34 V K 0.866 Pathogenic MSH2 P43246 V34L 34 V L 0.168 Neutral MSH2 P43246 V34M 34 V M 0.644 Pathogenic MSH2 P43246 V34N 34 V N 0.778 Pathogenic MSH2 P43246 V34P 34 V P 0.904 Pathogenic MSH2 P43246 V34Q 34 V Q 0.554 Pathogenic MSH2 P43246 V34R 34 V R 0.876 Pathogenic MSH2 P43246 V34S 34 V S 0.578 Pathogenic MSH2 P43246 V34T 34 V T 0.552 Pathogenic MSH2 P43246 V34W 34 V W 0.872 Pathogenic MSH2 P43246 V34Y 34 V Y 0.512 Pathogenic MSH2 P43246 R340A 340 R A 0.558 Pathogenic MSH2 P43246 R340C 340 R C 0.932 Pathogenic MSH2 P43246 R340D 340 R D 0.692 Pathogenic MSH2 P43246 R340E 340 R E 0.49 Neutral MSH2 P43246 R340F 340 R F 0.964 Pathogenic MSH2 P43246 R340G 340 R G 0.356 Neutral MSH2 P43246 R340H 340 R H 0.41 Neutral MSH2 P43246 R340I 340 R I 0.962 Pathogenic MSH2 P43246 R340K 340 R K 0.58 Pathogenic MSH2 P43246 R340L 340 R L 0.972 Pathogenic MSH2 P43246 R340M 340 R M 0.774 Pathogenic MSH2 P43246 R340N 340 R N 0.642 Pathogenic MSH2 P43246 R340P 340 R P 0.97 Pathogenic MSH2 P43246 R340Q 340 R Q 0.504 Pathogenic MSH2 P43246 R340S 340 R S 0.886 Pathogenic MSH2 P43246 R340T 340 R T 0.924 Pathogenic MSH2 P43246 R340V 340 R V 0.96 Pathogenic MSH2 P43246 R340W 340 R W 0.954 Pathogenic MSH2 P43246 R340Y 340 R Y 0.958 Pathogenic MSH2 P43246 L341A 341 L A 0.714 Pathogenic MSH2 P43246 L341C 341 L C 0.822 Pathogenic MSH2 P43246 L341D 341 L D 0.91 Pathogenic MSH2 P43246 L341E 341 L E 0.896 Pathogenic MSH2 P43246 L341F 341 L F 0.872 Pathogenic MSH2 P43246 L341G 341 L G 0.864 Pathogenic MSH2 P43246 L341H 341 L H 0.91 Pathogenic MSH2 P43246 L341I 341 L I 0.938 Pathogenic MSH2 P43246 L341K 341 L K 0.542 Pathogenic MSH2 P43246 L341M 341 L M 0.35 Neutral MSH2 P43246 L341N 341 L N 0.82 Pathogenic MSH2 P43246 L341P 341 L P 0.994 Pathogenic 4 MSH2 P43246 L341Q 341 L Q 0.544 Pathogenic MSH2 P43246 L341R 341 L R 0.672 Pathogenic MSH2 P43246 L341S 341 L S 0.706 Pathogenic MSH2 P43246 L341T 341 L T 0.45 Neutral MSH2 P43246 L341V 341 L V 0.424 Neutral MSH2 P43246 L341W 341 L W 0.878 Pathogenic MSH2 P43246 L341Y 341 L Y 0.89 Pathogenic MSH2 P43246 V342A 342 V A 0.482 Neutral MSH2 P43246 V342C 342 V C 0.804 Pathogenic MSH2 P43246 V342D 342 V D 0.86 Pathogenic MSH2 P43246 V342E 342 V E 0.964 Pathogenic MSH2 P43246 V342F 342 V F 0.614 Pathogenic MSH2 P43246 V342G 342 V G 0.912 Pathogenic MSH2 P43246 V342H 342 V H 0.898 Pathogenic MSH2 P43246 V342I 342 V I 0.272 Neutral MSH2 P43246 V342K 342 V K 0.988 Pathogenic MSH2 P43246 V342L 342 V L 0.248 Neutral MSH2 P43246 V342M 342 V M 0.29 Neutral MSH2 P43246 V342N 342 V N 0.922 Pathogenic MSH2 P43246 V342P 342 V P 0.986 Pathogenic MSH2 P43246 V342Q 342 V Q 0.972 Pathogenic MSH2 P43246 V342R 342 V R 0.948 Pathogenic MSH2 P43246 V342S 342 V S 0.804 Pathogenic MSH2 P43246 V342T 342 V T 0.878 Pathogenic MSH2 P43246 V342W 342 V W 0.954 Pathogenic MSH2 P43246 V342Y 342 V Y 0.974 Pathogenic MSH2 P43246 N343A 343 N A 0.072 Neutral MSH2 P43246 N343C 343 N C 0.586 Pathogenic MSH2 P43246 N343D 343 N D 0.59 Pathogenic MSH2 P43246 N343E 343 N E 0.586 Pathogenic MSH2 P43246 N343F 343 N F 0.92 Pathogenic MSH2 P43246 N343G 343 N G 0.066 Neutral MSH2 P43246 N343H 343 N H 0.068 Neutral MSH2 P43246 N343I 343 N I 0.896 Pathogenic MSH2 P43246 N343K 343 N K 0.804 Pathogenic MSH2 P43246 N343L 343 N L 0.208 Neutral MSH2 P43246 N343M 343 N M 0.864 Pathogenic MSH2 P43246 N343P 343 N P 0.778 Pathogenic MSH2 P43246 N343Q 343 N Q 0.298 Neutral MSH2 P43246 N343R 343 N R 0.55 Pathogenic MSH2 P43246 N343S 343 N S 0.032 Neutral MSH2 P43246 N343T 343 N T 0.042 Neutral MSH2 P43246 N343V 343 N V 0.452 Neutral MSH2 P43246 N343W 343 N W 0.956 Pathogenic MSH2 P43246 N343Y 343 N Y 0.948 Pathogenic MSH2 P43246 Q344A 344 Q A 0.386 Neutral MSH2 P43246 Q344C 344 Q C 0.664 Pathogenic MSH2 P43246 Q344D 344 Q D 0.74 Pathogenic MSH2 P43246 Q344E 344 Q E 0.244 Neutral MSH2 P43246 Q344F 344 Q F 0.92 Pathogenic MSH2 P43246 Q344G 344 Q G 0.56 Pathogenic MSH2 P43246 Q344H 344 Q H 0.982 Pathogenic MSH2 P43246 Q344I 344 Q I 0.952 Pathogenic MSH2 P43246 Q344K 344 Q K 0.416 Neutral MSH2 P43246 Q344L 344 Q L 0.766 Pathogenic MSH2 P43246 Q344M 344 Q M 0.318 Neutral MSH2 P43246 Q344N 344 Q N 0.768 Pathogenic MSH2 P43246 Q344P 344 Q P 0.916 Pathogenic MSH2 P43246 Q344R 344 Q R 0.31 Neutral MSH2 P43246 Q344S 344 Q S 0.238 Neutral MSH2 P43246 Q344T 344 Q T 0.214 Neutral MSH2 P43246 Q344V 344 Q V 0.34 Neutral MSH2 P43246 Q344W 344 Q W 0.958 Pathogenic MSH2 P43246 Q344Y 344 Q Y 0.95 Pathogenic MSH2 P43246 W345A 345 W A 0.478 Neutral MSH2 P43246 W345C 345 W C 0.39 Neutral MSH2 P43246 W345D 345 W D 0.51 Pathogenic MSH2 P43246 W345E 345 W E 0.85 Pathogenic MSH2 P43246 W345F 345 W F 0.726 Pathogenic MSH2 P43246 W345G 345 W G 0.476 Neutral MSH2 P43246 W345H 345 W H 0.732 Pathogenic MSH2 P43246 W345I 345 W I 0.546 Pathogenic MSH2 P43246 W345K 345 W K 0.904 Pathogenic MSH2 P43246 W345L 345 W L 0.498 Neutral MSH2 P43246 W345M 345 W M 0.73 Pathogenic MSH2 P43246 W345N 345 W N 0.486 Neutral MSH2 P43246 W345P 345 W P 0.514 Pathogenic MSH2 P43246 W345Q 345 W Q 0.662 Pathogenic MSH2 P43246 W345R 345 W R 0.748 Pathogenic MSH2 P43246 W345S 345 W S 0.486 Neutral MSH2 P43246 W345T 345 W T 0.478 Neutral MSH2 P43246 W345V 345 W V 0.432 Neutral MSH2 P43246 W345Y 345 W Y 0.734 Pathogenic MSH2 P43246 I346A 346 I A 0.526 Pathogenic MSH2 P43246 I346C 346 I C 0.64 Pathogenic MSH2 P43246 I346D 346 I D 0.736 Pathogenic MSH2 P43246 I346E 346 I E 0.748 Pathogenic MSH2 P43246 I346F 346 I F 0.96 Pathogenic MSH2 P43246 I346G 346 I G 0.798 Pathogenic MSH2 P43246 I346H 346 I H 0.89 Pathogenic MSH2 P43246 I346K 346 I K 0.844 Pathogenic MSH2 P43246 I346L 346 I L 0.202 Neutral MSH2 P43246 I346M 346 I M 0.422 Neutral MSH2 P43246 I346N 346 I N 0.762 Pathogenic MSH2 P43246 I346P 346 I P 0.922 Pathogenic MSH2 P43246 I346Q 346 I Q 0.778 Pathogenic MSH2 P43246 I346R 346 I R 0.666 Pathogenic MSH2 P43246 I346S 346 I S 0.616 Pathogenic MSH2 P43246 I346T 346 I T 0.318 Neutral MSH2 P43246 I346V 346 I V 0.118 Neutral MSH2 P43246 I346W 346 I W 0.986 Pathogenic MSH2 P43246 I346Y 346 I Y 0.976 Pathogenic MSH2 P43246 K347A 347 K A 0.702 Pathogenic MSH2 P43246 K347C 347 K C 0.598 Pathogenic MSH2 P43246 K347D 347 K D 0.774 Pathogenic MSH2 P43246 K347E 347 K E 0.874 Pathogenic MSH2 P43246 K347F 347 K F 0.962 Pathogenic MSH2 P43246 K347G 347 K G 0.54 Pathogenic MSH2 P43246 K347H 347 K H 0.522 Pathogenic MSH2 P43246 K347I 347 K I 0.99 Pathogenic MSH2 P43246 K347L 347 K L 0.982 Pathogenic MSH2 P43246 K347M 347 K M 0.886 Pathogenic MSH2 P43246 K347N 347 K N 0.488 Neutral MSH2 P43246 K347P 347 K P 0.928 Pathogenic MSH2 P43246 K347Q 347 K Q 0.858 Pathogenic MSH2 P43246 K347R 347 K R 0.402 Neutral MSH2 P43246 K347S 347 K S 0.42 Neutral MSH2 P43246 K347T 347 K T 0.668 Pathogenic MSH2 P43246 K347V 347 K V 0.658 Pathogenic MSH2 P43246 K347W 347 K W 0.986 Pathogenic MSH2 P43246 K347Y 347 K Y 0.976 Pathogenic MSH2 P43246 Q348A 348 Q A 0.784 Pathogenic MSH2 P43246 Q348C 348 Q C 0.768 Pathogenic MSH2 P43246 Q348D 348 Q D 0.862 Pathogenic MSH2 P43246 Q348E 348 Q E 0.65 Pathogenic MSH2 P43246 Q348F 348 Q F 0.918 Pathogenic MSH2 P43246 Q348G 348 Q G 0.506 Pathogenic MSH2 P43246 Q348H 348 Q H 0.928 Pathogenic MSH2 P43246 Q348I 348 Q I 0.94 Pathogenic MSH2 P43246 Q348K 348 Q K 0.922 Pathogenic MSH2 P43246 Q348L 348 Q L 0.778 Pathogenic MSH2 P43246 Q348M 348 Q M 0.9 Pathogenic MSH2 P43246 Q348N 348 Q N 0.896 Pathogenic MSH2 P43246 Q348P 348 Q P 0.904 Pathogenic MSH2 P43246 Q348R 348 Q R 0.924 Pathogenic MSH2 P43246 Q348S 348 Q S 0.678 Pathogenic MSH2 P43246 Q348T 348 Q T 0.508 Pathogenic MSH2 P43246 Q348V 348 Q V 0.914 Pathogenic MSH2 P43246 Q348W 348 Q W 0.954 Pathogenic MSH2 P43246 Q348Y 348 Q Y 0.94 Pathogenic MSH2 P43246 P349A 349 P A 0.84 Pathogenic MSH2 P43246 P349C 349 P C 0.918 Pathogenic MSH2 P43246 P349D 349 P D 0.87 Pathogenic MSH2 P43246 P349E 349 P E 0.956 Pathogenic MSH2 P43246 P349F 349 P F 1 Pathogenic MSH2 P43246 P349G 349 P G 0.694 Pathogenic MSH2 P43246 P349H 349 P H 0.976 Pathogenic MSH2 P43246 P349I 349 P I 0.938 Pathogenic MSH2 P43246 P349K 349 P K 0.946 Pathogenic MSH2 P43246 P349L 349 P L 0.998 Pathogenic 5 MSH2 P43246 P349M 349 P M 0.956 Pathogenic MSH2 P43246 P349N 349 P N 0.792 Pathogenic MSH2 P43246 P349Q 349 P Q 0.878 Pathogenic MSH2 P43246 P349R 349 P R 0.984 Pathogenic 4 MSH2 P43246 P349S 349 P S 0.368 Neutral MSH2 P43246 P349T 349 P T 0.752 Pathogenic MSH2 P43246 P349V 349 P V 0.844 Pathogenic MSH2 P43246 P349W 349 P W 0.936 Pathogenic MSH2 P43246 P349Y 349 P Y 0.932 Pathogenic MSH2 P43246 R35A 35 R A 0.566 Pathogenic MSH2 P43246 R35C 35 R C 0.95 Pathogenic MSH2 P43246 R35D 35 R D 0.676 Pathogenic MSH2 P43246 R35E 35 R E 0.776 Pathogenic MSH2 P43246 R35F 35 R F 0.966 Pathogenic MSH2 P43246 R35G 35 R G 0.406 Neutral MSH2 P43246 R35H 35 R H 0.354 Neutral MSH2 P43246 R35I 35 R I 0.974 Pathogenic MSH2 P43246 R35K 35 R K 0.736 Pathogenic MSH2 P43246 R35L 35 R L 0.988 Pathogenic MSH2 P43246 R35M 35 R M 0.77 Pathogenic MSH2 P43246 R35N 35 R N 0.634 Pathogenic MSH2 P43246 R35P 35 R P 0.986 Pathogenic MSH2 P43246 R35Q 35 R Q 0.486 Neutral MSH2 P43246 R35S 35 R S 0.91 Pathogenic MSH2 P43246 R35T 35 R T 0.374 Neutral MSH2 P43246 R35V 35 R V 0.974 Pathogenic MSH2 P43246 R35W 35 R W 0.844 Pathogenic MSH2 P43246 R35Y 35 R Y 0.954 Pathogenic MSH2 P43246 L350A 350 L A 0.716 Pathogenic MSH2 P43246 L350C 350 L C 0.83 Pathogenic MSH2 P43246 L350D 350 L D 0.912 Pathogenic MSH2 P43246 L350E 350 L E 0.894 Pathogenic MSH2 P43246 L350F 350 L F 0.884 Pathogenic MSH2 P43246 L350G 350 L G 0.862 Pathogenic MSH2 P43246 L350H 350 L H 0.908 Pathogenic MSH2 P43246 L350I 350 L I 0.94 Pathogenic MSH2 P43246 L350K 350 L K 0.732 Pathogenic MSH2 P43246 L350M 350 L M 0.624 Pathogenic MSH2 P43246 L350N 350 L N 0.822 Pathogenic MSH2 P43246 L350P 350 L P 0.986 Pathogenic MSH2 P43246 L350Q 350 L Q 0.778 Pathogenic MSH2 P43246 L350R 350 L R 0.982 Pathogenic MSH2 P43246 L350S 350 L S 0.712 Pathogenic MSH2 P43246 L350T 350 L T 0.636 Pathogenic MSH2 P43246 L350V 350 L V 0.456 Neutral MSH2 P43246 L350W 350 L W 0.886 Pathogenic MSH2 P43246 L350Y 350 L Y 0.896 Pathogenic MSH2 P43246 M351A 351 M A 0.322 Neutral MSH2 P43246 M351C 351 M C 0.082 Neutral MSH2 P43246 M351D 351 M D 0.664 Pathogenic MSH2 P43246 M351E 351 M E 0.422 Neutral MSH2 P43246 M351F 351 M F 0.738 Pathogenic MSH2 P43246 M351G 351 M G 0.35 Neutral MSH2 P43246 M351H 351 M H 0.496 Neutral MSH2 P43246 M351I 351 M I 0.064 Neutral MSH2 P43246 M351K 351 M K 0.102 Neutral MSH2 P43246 M351L 351 M L 0.036 Neutral MSH2 P43246 M351N 351 M N 0.678 Pathogenic MSH2 P43246 M351P 351 M P 0.876 Pathogenic MSH2 P43246 M351Q 351 M Q 0.074 Neutral MSH2 P43246 M351R 351 M R 0.102 Neutral MSH2 P43246 M351S 351 M S 0.392 Neutral MSH2 P43246 M351T 351 M T 0.024 Neutral MSH2 P43246 M351V 351 M V 0.056 Neutral MSH2 P43246 M351W 351 M W 0.956 Pathogenic MSH2 P43246 M351Y 351 M Y 0.88 Pathogenic MSH2 P43246 D352A 352 D A 0.668 Pathogenic MSH2 P43246 D352C 352 D C 0.574 Pathogenic MSH2 P43246 D352E 352 D E 0.406 Neutral MSH2 P43246 D352F 352 D F 0.984 Pathogenic MSH2 P43246 D352G 352 D G 0.892 Pathogenic MSH2 P43246 D352H 352 D H 0.62 Pathogenic MSH2 P43246 D352I 352 D I 0.974 Pathogenic MSH2 P43246 D352K 352 D K 0.974 Pathogenic MSH2 P43246 D352L 352 D L 0.982 Pathogenic MSH2 P43246 D352M 352 D M 0.944 Pathogenic MSH2 P43246 D352N 352 D N 0.052 Neutral MSH2 P43246 D352P 352 D P 0.912 Pathogenic MSH2 P43246 D352Q 352 D Q 0.772 Pathogenic MSH2 P43246 D352R 352 D R 0.89 Pathogenic MSH2 P43246 D352S 352 D S 0.104 Neutral MSH2 P43246 D352T 352 D T 0.212 Neutral MSH2 P43246 D352V 352 D V 0.996 Pathogenic MSH2 P43246 D352W 352 D W 0.986 Pathogenic MSH2 P43246 D352Y 352 D Y 0.98 Pathogenic MSH2 P43246 K353A 353 K A 0.078 Neutral MSH2 P43246 K353C 353 K C 0.16 Neutral MSH2 P43246 K353D 353 K D 0.256 Neutral MSH2 P43246 K353E 353 K E 0.298 Neutral MSH2 P43246 K353F 353 K F 0.424 Neutral MSH2 P43246 K353G 353 K G 0.334 Neutral MSH2 P43246 K353H 353 K H 0.016 Neutral MSH2 P43246 K353I 353 K I 0.106 Neutral MSH2 P43246 K353L 353 K L 0.09 Neutral MSH2 P43246 K353M 353 K M 0.586 Pathogenic MSH2 P43246 K353N 353 K N 0.302 Neutral MSH2 P43246 K353P 353 K P 0.386 Neutral MSH2 P43246 K353Q 353 K Q 0.034 Neutral MSH2 P43246 K353R 353 K R 0.03 Neutral MSH2 P43246 K353S 353 K S 0.434 Neutral MSH2 P43246 K353T 353 K T 0.08 Neutral MSH2 P43246 K353V 353 K V 0.104 Neutral MSH2 P43246 K353W 353 K W 0.976 Pathogenic MSH2 P43246 K353Y 353 K Y 0.592 Pathogenic MSH2 P43246 N354A 354 N A 0.064 Neutral MSH2 P43246 N354C 354 N C 0.604 Pathogenic MSH2 P43246 N354D 354 N D 0.03 Neutral MSH2 P43246 N354E 354 N E 0.038 Neutral MSH2 P43246 N354F 354 N F 0.9 Pathogenic MSH2 P43246 N354G 354 N G 0.066 Neutral MSH2 P43246 N354H 354 N H 0.052 Neutral MSH2 P43246 N354I 354 N I 0.824 Pathogenic MSH2 P43246 N354K 354 N K 0.072 Neutral MSH2 P43246 N354L 354 N L 0.822 Pathogenic MSH2 P43246 N354M 354 N M 0.782 Pathogenic MSH2 P43246 N354P 354 N P 0.72 Pathogenic MSH2 P43246 N354Q 354 N Q 0.042 Neutral MSH2 P43246 N354R 354 N R 0.52 Pathogenic MSH2 P43246 N354S 354 N S 0.018 Neutral MSH2 P43246 N354T 354 N T 0.028 Neutral MSH2 P43246 N354V 354 N V 0.806 Pathogenic MSH2 P43246 N354W 354 N W 0.926 Pathogenic MSH2 P43246 N354Y 354 N Y 0.91 Pathogenic MSH2 P43246 R355A 355 R A 0.108 Neutral MSH2 P43246 R355C 355 R C 0.648 Pathogenic MSH2 P43246 R355D 355 R D 0.05 Neutral MSH2 P43246 R355E 355 R E 0.234 Neutral MSH2 P43246 R355F 355 R F 0.81 Pathogenic MSH2 P43246 R355G 355 R G 0.108 Neutral MSH2 P43246 R355H 355 R H 0.04 Neutral MSH2 P43246 R355I 355 R I 0.168 Neutral MSH2 P43246 R355K 355 R K 0.04 Neutral MSH2 P43246 R355L 355 R L 0.112 Neutral MSH2 P43246 R355M 355 R M 0.652 Pathogenic MSH2 P43246 R355N 355 R N 0.504 Pathogenic MSH2 P43246 R355P 355 R P 0.82 Pathogenic MSH2 P43246 R355Q 355 R Q 0.072 Neutral MSH2 P43246 R355S 355 R S 0.072 Neutral MSH2 P43246 R355T 355 R T 0.45 Neutral MSH2 P43246 R355V 355 R V 0.656 Pathogenic MSH2 P43246 R355W 355 R W 0.894 Pathogenic MSH2 P43246 R355Y 355 R Y 0.846 Pathogenic MSH2 P43246 I356A 356 I A 0.428 Neutral MSH2 P43246 I356C 356 I C 0.738 Pathogenic MSH2 P43246 I356D 356 I D 0.812 Pathogenic MSH2 P43246 I356E 356 I E 0.814 Pathogenic MSH2 P43246 I356F 356 I F 0.84 Pathogenic MSH2 P43246 I356G 356 I G 0.874 Pathogenic MSH2 P43246 I356H 356 I H 0.91 Pathogenic MSH2 P43246 I356K 356 I K 0.854 Pathogenic MSH2 P43246 I356L 356 I L 0.278 Neutral MSH2 P43246 I356M 356 I M 0.67 Pathogenic MSH2 P43246 I356N 356 I N 0.834 Pathogenic MSH2 P43246 I356P 356 I P 0.932 Pathogenic MSH2 P43246 I356Q 356 I Q 0.842 Pathogenic MSH2 P43246 I356R 356 I R 0.904 Pathogenic MSH2 P43246 I356S 356 I S 0.72 Pathogenic MSH2 P43246 I356T 356 I T 0.342 Neutral MSH2 P43246 I356V 356 I V 0.382 Neutral MSH2 P43246 I356W 356 I W 0.896 Pathogenic MSH2 P43246 I356Y 356 I Y 0.872 Pathogenic MSH2 P43246 E357A 357 E A 0.328 Neutral MSH2 P43246 E357C 357 E C 0.502 Pathogenic MSH2 P43246 E357D 357 E D 0.088 Neutral MSH2 P43246 E357F 357 E F 0.886 Pathogenic MSH2 P43246 E357G 357 E G 0.212 Neutral MSH2 P43246 E357H 357 E H 0.056 Neutral MSH2 P43246 E357I 357 E I 0.842 Pathogenic MSH2 P43246 E357K 357 E K 0.04 Neutral MSH2 P43246 E357L 357 E L 0.132 Neutral MSH2 P43246 E357M 357 E M 0.71 Pathogenic MSH2 P43246 E357N 357 E N 0.014 Neutral MSH2 P43246 E357P 357 E P 0.886 Pathogenic MSH2 P43246 E357Q 357 E Q 0.012 Neutral MSH2 P43246 E357R 357 E R 0.144 Neutral MSH2 P43246 E357S 357 E S 0.062 Neutral MSH2 P43246 E357T 357 E T 0.052 Neutral MSH2 P43246 E357V 357 E V 0.412 Neutral MSH2 P43246 E357W 357 E W 0.964 Pathogenic MSH2 P43246 E357Y 357 E Y 0.922 Pathogenic MSH2 P43246 E358A 358 E A 0.556 Pathogenic MSH2 P43246 E358C 358 E C 0.102 Neutral MSH2 P43246 E358D 358 E D 0.018 Neutral MSH2 P43246 E358F 358 E F 0.854 Pathogenic MSH2 P43246 E358G 358 E G 0.196 Neutral MSH2 P43246 E358H 358 E H 0.64 Pathogenic MSH2 P43246 E358I 358 E I 0.912 Pathogenic MSH2 P43246 E358K 358 E K 0.034 Neutral MSH2 P43246 E358L 358 E L 0.816 Pathogenic MSH2 P43246 E358M 358 E M 0.668 Pathogenic MSH2 P43246 E358N 358 E N 0.014 Neutral MSH2 P43246 E358P 358 E P 0.872 Pathogenic MSH2 P43246 E358Q 358 E Q 0.01 Neutral MSH2 P43246 E358R 358 E R 0.12 Neutral MSH2 P43246 E358S 358 E S 0.048 Neutral MSH2 P43246 E358T 358 E T 0.058 Neutral MSH2 P43246 E358V 358 E V 0.226 Neutral MSH2 P43246 E358W 358 E W 0.968 Pathogenic MSH2 P43246 E358Y 358 E Y 0.912 Pathogenic MSH2 P43246 R359A 359 R A 0.566 Pathogenic MSH2 P43246 R359C 359 R C 0.95 Pathogenic MSH2 P43246 R359D 359 R D 0.708 Pathogenic MSH2 P43246 R359E 359 R E 0.806 Pathogenic MSH2 P43246 R359F 359 R F 0.97 Pathogenic MSH2 P43246 R359G 359 R G 0.39 Neutral MSH2 P43246 R359H 359 R H 0.428 Neutral MSH2 P43246 R359I 359 R I 0.97 Pathogenic MSH2 P43246 R359K 359 R K 0.624 Pathogenic MSH2 P43246 R359L 359 R L 0.984 Pathogenic MSH2 P43246 R359M 359 R M 0.792 Pathogenic MSH2 P43246 R359N 359 R N 0.67 Pathogenic MSH2 P43246 R359P 359 R P 0.982 Pathogenic MSH2 P43246 R359Q 359 R Q 0.534 Pathogenic MSH2 P43246 R359S 359 R S 0.916 Pathogenic 5 MSH2 P43246 R359T 359 R T 0.948 Pathogenic MSH2 P43246 R359V 359 R V 0.97 Pathogenic MSH2 P43246 R359W 359 R W 0.908 Pathogenic MSH2 P43246 R359Y 359 R Y 0.966 Pathogenic MSH2 P43246 L36A 36 L A 0.124 Neutral MSH2 P43246 L36C 36 L C 0.402 Neutral MSH2 P43246 L36D 36 L D 0.678 Pathogenic MSH2 P43246 L36E 36 L E 0.632 Pathogenic MSH2 P43246 L36F 36 L F 0.276 Neutral MSH2 P43246 L36G 36 L G 0.586 Pathogenic MSH2 P43246 L36H 36 L H 0.424 Neutral MSH2 P43246 L36I 36 L I 0.034 Neutral MSH2 P43246 L36K 36 L K 0.484 Neutral MSH2 P43246 L36M 36 L M 0.468 Neutral MSH2 P43246 L36N 36 L N 0.624 Pathogenic MSH2 P43246 L36P 36 L P 0.954 Pathogenic MSH2 P43246 L36Q 36 L Q 0.364 Neutral MSH2 P43246 L36R 36 L R 0.872 Pathogenic MSH2 P43246 L36S 36 L S 0.402 Neutral MSH2 P43246 L36T 36 L T 0.388 Neutral MSH2 P43246 L36V 36 L V 0.002 Neutral MSH2 P43246 L36W 36 L W 0.798 Pathogenic MSH2 P43246 L36Y 36 L Y 0.84 Pathogenic MSH2 P43246 L360A 360 L A 0.566 Pathogenic MSH2 P43246 L360C 360 L C 0.692 Pathogenic MSH2 P43246 L360D 360 L D 0.886 Pathogenic MSH2 P43246 L360E 360 L E 0.872 Pathogenic MSH2 P43246 L360F 360 L F 0.976 Pathogenic MSH2 P43246 L360G 360 L G 0.788 Pathogenic MSH2 P43246 L360H 360 L H 0.188 Neutral MSH2 P43246 L360I 360 L I 0.842 Pathogenic MSH2 P43246 L360K 360 L K 0.742 Pathogenic MSH2 P43246 L360M 360 L M 0.742 Pathogenic MSH2 P43246 L360N 360 L N 0.752 Pathogenic MSH2 P43246 L360P 360 L P 0.986 Pathogenic MSH2 P43246 L360Q 360 L Q 0.146 Neutral MSH2 P43246 L360R 360 L R 0.99 Pathogenic MSH2 P43246 L360S 360 L S 0.596 Pathogenic MSH2 P43246 L360T 360 L T 0.578 Pathogenic MSH2 P43246 L360V 360 L V 0.546 Pathogenic MSH2 P43246 L360W 360 L W 0.94 Pathogenic MSH2 P43246 L360Y 360 L Y 0.906 Pathogenic MSH2 P43246 N361A 361 N A 0.514 Pathogenic MSH2 P43246 N361C 361 N C 0.522 Pathogenic MSH2 P43246 N361D 361 N D 0.094 Neutral MSH2 P43246 N361E 361 N E 0.07 Neutral MSH2 P43246 N361F 361 N F 0.874 Pathogenic MSH2 P43246 N361G 361 N G 0.228 Neutral MSH2 P43246 N361H 361 N H 0.702 Pathogenic MSH2 P43246 N361I 361 N I 0.814 Pathogenic MSH2 P43246 N361K 361 N K 0.742 Pathogenic MSH2 P43246 N361L 361 N L 0.758 Pathogenic MSH2 P43246 N361M 361 N M 0.388 Neutral MSH2 P43246 N361P 361 N P 0.7 Pathogenic MSH2 P43246 N361Q 361 N Q 0.046 Neutral MSH2 P43246 N361R 361 N R 0.462 Neutral MSH2 P43246 N361S 361 N S 0.054 Neutral MSH2 P43246 N361T 361 N T 0.034 Neutral MSH2 P43246 N361V 361 N V 0.876 Pathogenic MSH2 P43246 N361W 361 N W 0.92 Pathogenic MSH2 P43246 N361Y 361 N Y 0.908 Pathogenic MSH2 P43246 L362A 362 L A 0.658 Pathogenic MSH2 P43246 L362C 362 L C 0.78 Pathogenic MSH2 P43246 L362D 362 L D 0.89 Pathogenic MSH2 P43246 L362E 362 L E 0.868 Pathogenic MSH2 P43246 L362F 362 L F 0.544 Pathogenic MSH2 P43246 L362G 362 L G 0.806 Pathogenic MSH2 P43246 L362H 362 L H 0.89 Pathogenic MSH2 P43246 L362I 362 L I 0.186 Neutral MSH2 P43246 L362K 362 L K 0.754 Pathogenic MSH2 P43246 L362M 362 L M 0.176 Neutral MSH2 P43246 L362N 362 L N 0.754 Pathogenic MSH2 P43246 L362P 362 L P 0.992 Pathogenic MSH2 P43246 L362Q 362 L Q 0.708 Pathogenic MSH2 P43246 L362R 362 L R 0.984 Pathogenic MSH2 P43246 L362S 362 L S 0.636 Pathogenic MSH2 P43246 L362T 362 L T 0.302 Neutral MSH2 P43246 L362V 362 L V 0.07 Neutral MSH2 P43246 L362W 362 L W 0.938 Pathogenic MSH2 P43246 L362Y 362 L Y 0.9 Pathogenic MSH2 P43246 V363A 363 V A 0.544 Pathogenic MSH2 P43246 V363C 363 V C 0.82 Pathogenic MSH2 P43246 V363D 363 V D 0.87 Pathogenic MSH2 P43246 V363E 363 V E 0.96 Pathogenic MSH2 P43246 V363F 363 V F 0.932 Pathogenic MSH2 P43246 V363G 363 V G 0.924 Pathogenic MSH2 P43246 V363H 363 V H 0.914 Pathogenic MSH2 P43246 V363I 363 V I 0.63 Pathogenic MSH2 P43246 V363K 363 V K 0.984 Pathogenic MSH2 P43246 V363L 363 V L 0.582 Pathogenic MSH2 P43246 V363M 363 V M 0.922 Pathogenic MSH2 P43246 V363N 363 V N 0.926 Pathogenic MSH2 P43246 V363P 363 V P 0.992 Pathogenic MSH2 P43246 V363Q 363 V Q 0.966 Pathogenic MSH2 P43246 V363R 363 V R 0.952 Pathogenic MSH2 P43246 V363S 363 V S 0.822 Pathogenic MSH2 P43246 V363T 363 V T 0.888 Pathogenic MSH2 P43246 V363W 363 V W 0.956 Pathogenic MSH2 P43246 V363Y 363 V Y 0.976 Pathogenic MSH2 P43246 E364A 364 E A 0.45 Neutral MSH2 P43246 E364C 364 E C 0.752 Pathogenic MSH2 P43246 E364D 364 E D 0.2 Neutral MSH2 P43246 E364F 364 E F 0.972 Pathogenic MSH2 P43246 E364G 364 E G 0.094 Neutral MSH2 P43246 E364H 364 E H 0.654 Pathogenic MSH2 P43246 E364I 364 E I 0.98 Pathogenic MSH2 P43246 E364K 364 E K 0.98 Pathogenic MSH2 P43246 E364L 364 E L 0.98 Pathogenic MSH2 P43246 E364M 364 E M 0.922 Pathogenic MSH2 P43246 E364N 364 E N 0.168 Neutral MSH2 P43246 E364P 364 E P 0.936 Pathogenic MSH2 P43246 E364Q 364 E Q 0.158 Neutral MSH2 P43246 E364R 364 E R 0.928 Pathogenic MSH2 P43246 E364S 364 E S 0.318 Neutral MSH2 P43246 E364T 364 E T 0.888 Pathogenic MSH2 P43246 E364V 364 E V 0.918 Pathogenic MSH2 P43246 E364W 364 E W 0.986 Pathogenic MSH2 P43246 E364Y 364 E Y 0.966 Pathogenic MSH2 P43246 A365C 365 A C 0.178 Neutral MSH2 P43246 A365D 365 A D 0.862 Pathogenic MSH2 P43246 A365E 365 A E 0.704 Pathogenic MSH2 P43246 A365F 365 A F 0.63 Pathogenic MSH2 P43246 A365G 365 A G 0.446 Neutral MSH2 P43246 A365H 365 A H 0.872 Pathogenic MSH2 P43246 A365I 365 A I 0.62 Pathogenic MSH2 P43246 A365K 365 A K 0.914 Pathogenic MSH2 P43246 A365L 365 A L 0.576 Pathogenic MSH2 P43246 A365M 365 A M 0.546 Pathogenic MSH2 P43246 A365N 365 A N 0.772 Pathogenic MSH2 P43246 A365P 365 A P 0.916 Pathogenic MSH2 P43246 A365Q 365 A Q 0.54 Pathogenic MSH2 P43246 A365R 365 A R 0.906 Pathogenic MSH2 P43246 A365S 365 A S 0.012 Neutral MSH2 P43246 A365T 365 A T 0.046 Neutral MSH2 P43246 A365V 365 A V 0.132 Neutral MSH2 P43246 A365W 365 A W 0.76 Pathogenic MSH2 P43246 A365Y 365 A Y 0.626 Pathogenic MSH2 P43246 F366A 366 F A 0.504 Pathogenic MSH2 P43246 F366C 366 F C 0.718 Pathogenic MSH2 P43246 F366D 366 F D 0.792 Pathogenic MSH2 P43246 F366E 366 F E 0.836 Pathogenic MSH2 P43246 F366G 366 F G 0.5 Pathogenic MSH2 P43246 F366H 366 F H 0.75 Pathogenic MSH2 P43246 F366I 366 F I 0.304 Neutral MSH2 P43246 F366K 366 F K 0.818 Pathogenic MSH2 P43246 F366L 366 F L 0.162 Neutral MSH2 P43246 F366M 366 F M 0.194 Neutral MSH2 P43246 F366N 366 F N 0.732 Pathogenic MSH2 P43246 F366P 366 F P 0.95 Pathogenic MSH2 P43246 F366Q 366 F Q 0.742 Pathogenic MSH2 P43246 F366R 366 F R 0.888 Pathogenic MSH2 P43246 F366S 366 F S 0.856 Pathogenic MSH2 P43246 F366T 366 F T 0.544 Pathogenic MSH2 P43246 F366V 366 F V 0.732 Pathogenic MSH2 P43246 F366W 366 F W 0.654 Pathogenic MSH2 P43246 F366Y 366 F Y 0.496 Neutral MSH2 P43246 V367A 367 V A 0.066 Neutral MSH2 P43246 V367C 367 V C 0.352 Neutral MSH2 P43246 V367D 367 V D 0.868 Pathogenic MSH2 P43246 V367E 367 V E 0.986 Pathogenic MSH2 P43246 V367F 367 V F 0.5 Pathogenic MSH2 P43246 V367G 367 V G 0.902 Pathogenic MSH2 P43246 V367H 367 V H 0.822 Pathogenic MSH2 P43246 V367I 367 V I 0.16 Neutral MSH2 P43246 V367K 367 V K 0.988 Pathogenic MSH2 P43246 V367L 367 V L 0.22 Neutral MSH2 P43246 V367M 367 V M 0.234 Neutral MSH2 P43246 V367N 367 V N 0.928 Pathogenic MSH2 P43246 V367P 367 V P 0.984 Pathogenic MSH2 P43246 V367Q 367 V Q 0.992 Pathogenic MSH2 P43246 V367R 367 V R 0.69 Pathogenic MSH2 P43246 V367S 367 V S 0.73 Pathogenic MSH2 P43246 V367T 367 V T 0.136 Neutral MSH2 P43246 V367W 367 V W 0.904 Pathogenic MSH2 P43246 V367Y 367 V Y 0.534 Pathogenic MSH2 P43246 E368A 368 E A 0.536 Pathogenic MSH2 P43246 E368C 368 E C 0.104 Neutral MSH2 P43246 E368D 368 E D 0.014 Neutral MSH2 P43246 E368F 368 E F 0.854 Pathogenic MSH2 P43246 E368G 368 E G 0.2 Neutral MSH2 P43246 E368H 368 E H 0.068 Neutral MSH2 P43246 E368I 368 E I 0.86 Pathogenic MSH2 P43246 E368K 368 E K 0.058 Neutral MSH2 P43246 E368L 368 E L 0.89 Pathogenic MSH2 P43246 E368M 368 E M 0.074 Neutral MSH2 P43246 E368N 368 E N 0.012 Neutral MSH2 P43246 E368P 368 E P 0.872 Pathogenic MSH2 P43246 E368Q 368 E Q 0.014 Neutral MSH2 P43246 E368R 368 E R 0.322 Neutral MSH2 P43246 E368S 368 E S 0.06 Neutral MSH2 P43246 E368T 368 E T 0.056 Neutral MSH2 P43246 E368V 368 E V 0.088 Neutral MSH2 P43246 E368W 368 E W 0.968 Pathogenic MSH2 P43246 E368Y 368 E Y 0.912 Pathogenic MSH2 P43246 D369A 369 D A 0.324 Neutral MSH2 P43246 D369C 369 D C 0.376 Neutral MSH2 P43246 D369E 369 D E 0.272 Neutral MSH2 P43246 D369F 369 D F 0.984 Pathogenic MSH2 P43246 D369G 369 D G 0.888 Pathogenic MSH2 P43246 D369H 369 D H 0.624 Pathogenic MSH2 P43246 D369I 369 D I 0.464 Neutral MSH2 P43246 D369K 369 D K 0.968 Pathogenic MSH2 P43246 D369L 369 D L 0.974 Pathogenic MSH2 P43246 D369M 369 D M 0.944 Pathogenic MSH2 P43246 D369N 369 D N 0.086 Neutral MSH2 P43246 D369P 369 D P 0.904 Pathogenic MSH2 P43246 D369Q 369 D Q 0.158 Neutral MSH2 P43246 D369R 369 D R 0.588 Pathogenic MSH2 P43246 D369S 369 D S 0.11 Neutral MSH2 P43246 D369T 369 D T 0.462 Neutral MSH2 P43246 D369V 369 D V 0.986 Pathogenic MSH2 P43246 D369W 369 D W 0.986 Pathogenic MSH2 P43246 D369Y 369 D Y 0.93 Pathogenic MSH2 P43246 F37A 37 F A 0.51 Pathogenic MSH2 P43246 F37C 37 F C 0.72 Pathogenic MSH2 P43246 F37D 37 F D 0.802 Pathogenic MSH2 P43246 F37E 37 F E 0.848 Pathogenic MSH2 P43246 F37G 37 F G 0.51 Pathogenic MSH2 P43246 F37H 37 F H 0.758 Pathogenic MSH2 P43246 F37I 37 F I 0.302 Neutral MSH2 P43246 F37K 37 F K 0.836 Pathogenic MSH2 P43246 F37L 37 F L 0.232 Neutral MSH2 P43246 F37M 37 F M 0.36 Neutral MSH2 P43246 F37N 37 F N 0.74 Pathogenic MSH2 P43246 F37P 37 F P 0.964 Pathogenic MSH2 P43246 F37Q 37 F Q 0.75 Pathogenic MSH2 P43246 F37R 37 F R 0.902 Pathogenic MSH2 P43246 F37S 37 F S 0.862 Pathogenic MSH2 P43246 F37T 37 F T 0.578 Pathogenic MSH2 P43246 F37V 37 F V 0.148 Neutral MSH2 P43246 F37W 37 F W 0.85 Pathogenic MSH2 P43246 F37Y 37 F Y 0.268 Neutral MSH2 P43246 A370C 370 A C 0.724 Pathogenic MSH2 P43246 A370D 370 A D 0.784 Pathogenic MSH2 P43246 A370E 370 A E 0.884 Pathogenic MSH2 P43246 A370F 370 A F 0.968 Pathogenic MSH2 P43246 A370G 370 A G 0.022 Neutral MSH2 P43246 A370H 370 A H 0.706 Pathogenic MSH2 P43246 A370I 370 A I 0.678 Pathogenic MSH2 P43246 A370K 370 A K 0.916 Pathogenic MSH2 P43246 A370L 370 A L 0.582 Pathogenic MSH2 P43246 A370M 370 A M 0.822 Pathogenic MSH2 P43246 A370N 370 A N 0.584 Pathogenic MSH2 P43246 A370P 370 A P 0.136 Neutral MSH2 P43246 A370Q 370 A Q 0.748 Pathogenic MSH2 P43246 A370R 370 A R 0.926 Pathogenic MSH2 P43246 A370S 370 A S 0.01 Neutral MSH2 P43246 A370T 370 A T 0.096 Neutral MSH2 P43246 A370V 370 A V 0.142 Neutral MSH2 P43246 A370W 370 A W 0.954 Pathogenic MSH2 P43246 A370Y 370 A Y 0.94 Pathogenic MSH2 P43246 E371A 371 E A 0.23 Neutral MSH2 P43246 E371C 371 E C 0.606 Pathogenic MSH2 P43246 E371D 371 E D 0.094 Neutral MSH2 P43246 E371F 371 E F 0.82 Pathogenic MSH2 P43246 E371G 371 E G 0.082 Neutral MSH2 P43246 E371H 371 E H 0.674 Pathogenic MSH2 P43246 E371I 371 E I 0.788 Pathogenic MSH2 P43246 E371K 371 E K 0.692 Pathogenic MSH2 P43246 E371L 371 E L 0.33 Neutral MSH2 P43246 E371M 371 E M 0.774 Pathogenic MSH2 P43246 E371N 371 E N 0.062 Neutral MSH2 P43246 E371P 371 E P 0.896 Pathogenic MSH2 P43246 E371Q 371 E Q 0.072 Neutral MSH2 P43246 E371R 371 E R 0.796 Pathogenic MSH2 P43246 E371S 371 E S 0.148 Neutral MSH2 P43246 E371T 371 E T 0.158 Neutral MSH2 P43246 E371V 371 E V 0.35 Neutral MSH2 P43246 E371W 371 E W 0.97 Pathogenic MSH2 P43246 E371Y 371 E Y 0.942 Pathogenic MSH2 P43246 L372A 372 L A 0.14 Neutral MSH2 P43246 L372C 372 L C 0.758 Pathogenic MSH2 P43246 L372D 372 L D 0.884 Pathogenic MSH2 P43246 L372E 372 L E 0.864 Pathogenic MSH2 P43246 L372F 372 L F 0.788 Pathogenic MSH2 P43246 L372G 372 L G 0.464 Neutral MSH2 P43246 L372H 372 L H 0.874 Pathogenic MSH2 P43246 L372I 372 L I 0.34 Neutral MSH2 P43246 L372K 372 L K 0.75 Pathogenic MSH2 P43246 L372M 372 L M 0.216 Neutral MSH2 P43246 L372N 372 L N 0.476 Neutral MSH2 P43246 L372P 372 L P 0.99 Pathogenic MSH2 P43246 L372Q 372 L Q 0.684 Pathogenic MSH2 P43246 L372R 372 L R 0.984 Pathogenic MSH2 P43246 L372S 372 L S 0.138 Neutral MSH2 P43246 L372T 372 L T 0.104 Neutral MSH2 P43246 L372V 372 L V 0.092 Neutral MSH2 P43246 L372W 372 L W 0.942 Pathogenic MSH2 P43246 L372Y 372 L Y 0.904 Pathogenic MSH2 P43246 R373A 373 R A 0.572 Pathogenic MSH2 P43246 R373C 373 R C 0.504 Pathogenic MSH2 P43246 R373D 373 R D 0.69 Pathogenic MSH2 P43246 R373E 373 R E 0.796 Pathogenic MSH2 P43246 R373F 373 R F 0.976 Pathogenic MSH2 P43246 R373G 373 R G 0.396 Neutral MSH2 P43246 R373H 373 R H 0.394 Neutral MSH2 P43246 R373I 373 R I 0.978 Pathogenic MSH2 P43246 R373K 373 R K 0.506 Pathogenic MSH2 P43246 R373L 373 R L 0.524 Pathogenic MSH2 P43246 R373M 373 R M 0.626 Pathogenic MSH2 P43246 R373N 373 R N 0.646 Pathogenic MSH2 P43246 R373P 373 R P 0.99 Pathogenic MSH2 P43246 R373Q 373 R Q 0.504 Pathogenic MSH2 P43246 R373S 373 R S 0.418 Neutral MSH2 P43246 R373T 373 R T 0.518 Pathogenic MSH2 P43246 R373V 373 R V 0.978 Pathogenic MSH2 P43246 R373W 373 R W 0.958 Pathogenic MSH2 P43246 R373Y 373 R Y 0.966 Pathogenic MSH2 P43246 Q374A 374 Q A 0.364 Neutral MSH2 P43246 Q374C 374 Q C 0.664 Pathogenic MSH2 P43246 Q374D 374 Q D 0.164 Neutral MSH2 P43246 Q374E 374 Q E 0.248 Neutral MSH2 P43246 Q374F 374 Q F 0.92 Pathogenic MSH2 P43246 Q374G 374 Q G 0.222 Neutral MSH2 P43246 Q374H 374 Q H 0.554 Pathogenic MSH2 P43246 Q374I 374 Q I 0.95 Pathogenic MSH2 P43246 Q374K 374 Q K 0.352 Neutral MSH2 P43246 Q374L 374 Q L 0.552 Pathogenic MSH2 P43246 Q374M 374 Q M 0.734 Pathogenic MSH2 P43246 Q374N 374 Q N 0.37 Neutral MSH2 P43246 Q374P 374 Q P 0.916 Pathogenic MSH2 P43246 Q374R 374 Q R 0.31 Neutral MSH2 P43246 Q374S 374 Q S 0.236 Neutral MSH2 P43246 Q374T 374 Q T 0.214 Neutral MSH2 P43246 Q374V 374 Q V 0.666 Pathogenic MSH2 P43246 Q374W 374 Q W 0.958 Pathogenic MSH2 P43246 Q374Y 374 Q Y 0.95 Pathogenic MSH2 P43246 T375A 375 T A 0.046 Neutral MSH2 P43246 T375C 375 T C 0.062 Neutral MSH2 P43246 T375D 375 T D 0.102 Neutral MSH2 P43246 T375E 375 T E 0.164 Neutral MSH2 P43246 T375F 375 T F 0.758 Pathogenic MSH2 P43246 T375G 375 T G 0.038 Neutral MSH2 P43246 T375H 375 T H 0.6 Pathogenic MSH2 P43246 T375I 375 T I 0.126 Neutral MSH2 P43246 T375K 375 T K 0.55 Pathogenic MSH2 P43246 T375L 375 T L 0.082 Neutral MSH2 P43246 T375M 375 T M 0.176 Neutral MSH2 P43246 T375N 375 T N 0.022 Neutral MSH2 P43246 T375P 375 T P 0.18 Neutral MSH2 P43246 T375Q 375 T Q 0.104 Neutral MSH2 P43246 T375R 375 T R 0.512 Pathogenic MSH2 P43246 T375S 375 T S 0.012 Neutral MSH2 P43246 T375V 375 T V 0.736 Pathogenic MSH2 P43246 T375W 375 T W 0.946 Pathogenic MSH2 P43246 T375Y 375 T Y 0.942 Pathogenic MSH2 P43246 L376A 376 L A 0.624 Pathogenic MSH2 P43246 L376C 376 L C 0.158 Neutral MSH2 P43246 L376D 376 L D 0.86 Pathogenic MSH2 P43246 L376E 376 L E 0.852 Pathogenic MSH2 P43246 L376F 376 L F 0.962 Pathogenic MSH2 P43246 L376G 376 L G 0.776 Pathogenic MSH2 P43246 L376H 376 L H 0.87 Pathogenic MSH2 P43246 L376I 376 L I 0.214 Neutral MSH2 P43246 L376K 376 L K 0.724 Pathogenic MSH2 P43246 L376M 376 L M 0.184 Neutral MSH2 P43246 L376N 376 L N 0.73 Pathogenic MSH2 P43246 L376P 376 L P 0.97 Pathogenic MSH2 P43246 L376Q 376 L Q 0.672 Pathogenic MSH2 P43246 L376R 376 L R 0.978 Pathogenic MSH2 P43246 L376S 376 L S 0.588 Pathogenic MSH2 P43246 L376T 376 L T 0.552 Pathogenic MSH2 P43246 L376V 376 L V 0.094 Neutral MSH2 P43246 L376W 376 L W 0.93 Pathogenic MSH2 P43246 L376Y 376 L Y 0.892 Pathogenic MSH2 P43246 Q377A 377 Q A 0.25 Neutral MSH2 P43246 Q377C 377 Q C 0.356 Neutral MSH2 P43246 Q377D 377 Q D 0.74 Pathogenic MSH2 P43246 Q377E 377 Q E 0.824 Pathogenic MSH2 P43246 Q377F 377 Q F 0.918 Pathogenic MSH2 P43246 Q377G 377 Q G 0.558 Pathogenic MSH2 P43246 Q377H 377 Q H 0.374 Neutral MSH2 P43246 Q377I 377 Q I 0.814 Pathogenic MSH2 P43246 Q377K 377 Q K 0.764 Pathogenic MSH2 P43246 Q377L 377 Q L 0.758 Pathogenic MSH2 P43246 Q377M 377 Q M 0.344 Neutral MSH2 P43246 Q377N 377 Q N 0.202 Neutral MSH2 P43246 Q377P 377 Q P 0.914 Pathogenic MSH2 P43246 Q377R 377 Q R 0.312 Neutral MSH2 P43246 Q377S 377 Q S 0.234 Neutral MSH2 P43246 Q377T 377 Q T 0.23 Neutral MSH2 P43246 Q377V 377 Q V 0.336 Neutral MSH2 P43246 Q377W 377 Q W 0.956 Pathogenic MSH2 P43246 Q377Y 377 Q Y 0.722 Pathogenic MSH2 P43246 E378A 378 E A 0.392 Neutral MSH2 P43246 E378C 378 E C 0.3 Neutral MSH2 P43246 E378D 378 E D 0.08 Neutral MSH2 P43246 E378F 378 E F 0.848 Pathogenic MSH2 P43246 E378G 378 E G 0.094 Neutral MSH2 P43246 E378H 378 E H 0.584 Pathogenic MSH2 P43246 E378I 378 E I 0.91 Pathogenic MSH2 P43246 E378K 378 E K 0.76 Pathogenic MSH2 P43246 E378L 378 E L 0.316 Neutral MSH2 P43246 E378M 378 E M 0.614 Pathogenic MSH2 P43246 E378N 378 E N 0.076 Neutral MSH2 P43246 E378P 378 E P 0.866 Pathogenic MSH2 P43246 E378Q 378 E Q 0.068 Neutral MSH2 P43246 E378R 378 E R 0.734 Pathogenic MSH2 P43246 E378S 378 E S 0.158 Neutral MSH2 P43246 E378T 378 E T 0.174 Neutral MSH2 P43246 E378V 378 E V 0.856 Pathogenic MSH2 P43246 E378W 378 E W 0.922 Pathogenic MSH2 P43246 E378Y 378 E Y 0.874 Pathogenic MSH2 P43246 D379A 379 D A 0.33 Neutral MSH2 P43246 D379C 379 D C 0.752 Pathogenic MSH2 P43246 D379E 379 D E 0.212 Neutral MSH2 P43246 D379F 379 D F 0.942 Pathogenic MSH2 P43246 D379G 379 D G 0.712 Pathogenic MSH2 P43246 D379H 379 D H 0.24 Neutral MSH2 P43246 D379I 379 D I 0.786 Pathogenic MSH2 P43246 D379K 379 D K 0.756 Pathogenic MSH2 P43246 D379L 379 D L 0.728 Pathogenic MSH2 P43246 D379M 379 D M 0.852 Pathogenic MSH2 P43246 D379N 379 D N 0.08 Neutral MSH2 P43246 D379P 379 D P 0.816 Pathogenic MSH2 P43246 D379Q 379 D Q 0.152 Neutral MSH2 P43246 D379R 379 D R 0.606 Pathogenic MSH2 P43246 D379S 379 D S 0.6 Pathogenic MSH2 P43246 D379T 379 D T 0.166 Neutral MSH2 P43246 D379V 379 D V 0.532 Pathogenic MSH2 P43246 D379W 379 D W 0.956 Pathogenic MSH2 P43246 D379Y 379 D Y 0.948 Pathogenic MSH2 P43246 D38A 38 D A 0.316 Neutral MSH2 P43246 D38C 38 D C 0.896 Pathogenic MSH2 P43246 D38E 38 D E 0.208 Neutral MSH2 P43246 D38F 38 D F 0.548 Pathogenic MSH2 P43246 D38G 38 D G 0.374 Neutral MSH2 P43246 D38H 38 D H 0.356 Neutral MSH2 P43246 D38I 38 D I 0.798 Pathogenic MSH2 P43246 D38K 38 D K 0.808 Pathogenic MSH2 P43246 D38L 38 D L 0.754 Pathogenic MSH2 P43246 D38M 38 D M 0.934 Pathogenic MSH2 P43246 D38N 38 D N 0.08 Neutral MSH2 P43246 D38P 38 D P 0.91 Pathogenic MSH2 P43246 D38Q 38 D Q 0.77 Pathogenic MSH2 P43246 D38R 38 D R 0.892 Pathogenic MSH2 P43246 D38S 38 D S 0.114 Neutral MSH2 P43246 D38T 38 D T 0.822 Pathogenic MSH2 P43246 D38V 38 D V 0.99 Pathogenic MSH2 P43246 D38W 38 D W 0.986 Pathogenic MSH2 P43246 D38Y 38 D Y 0.812 Pathogenic MSH2 P43246 L380A 380 L A 0.168 Neutral MSH2 P43246 L380C 380 L C 0.338 Neutral MSH2 P43246 L380D 380 L D 0.608 Pathogenic MSH2 P43246 L380E 380 L E 0.456 Neutral MSH2 P43246 L380F 380 L F 0.288 Neutral MSH2 P43246 L380G 380 L G 0.538 Pathogenic MSH2 P43246 L380H 380 L H 0.04 Neutral MSH2 P43246 L380I 380 L I 0.076 Neutral MSH2 P43246 L380K 380 L K 0.44 Neutral MSH2 P43246 L380M 380 L M 0.448 Neutral MSH2 P43246 L380N 380 L N 0.566 Pathogenic MSH2 P43246 L380P 380 L P 0.626 Pathogenic MSH2 P43246 L380Q 380 L Q 0.046 Neutral MSH2 P43246 L380R 380 L R 0.778 Pathogenic MSH2 P43246 L380S 380 L S 0.462 Neutral MSH2 P43246 L380T 380 L T 0.232 Neutral MSH2 P43246 L380V 380 L V 0.204 Neutral MSH2 P43246 L380W 380 L W 0.868 Pathogenic MSH2 P43246 L380Y 380 L Y 0.618 Pathogenic MSH2 P43246 L381A 381 L A 0.706 Pathogenic MSH2 P43246 L381C 381 L C 0.82 Pathogenic MSH2 P43246 L381D 381 L D 0.888 Pathogenic MSH2 P43246 L381E 381 L E 0.868 Pathogenic MSH2 P43246 L381F 381 L F 0.634 Pathogenic MSH2 P43246 L381G 381 L G 0.828 Pathogenic MSH2 P43246 L381H 381 L H 0.908 Pathogenic MSH2 P43246 L381I 381 L I 0.518 Pathogenic MSH2 P43246 L381K 381 L K 0.724 Pathogenic MSH2 P43246 L381M 381 L M 0.156 Neutral MSH2 P43246 L381N 381 L N 0.764 Pathogenic MSH2 P43246 L381P 381 L P 0.994 Pathogenic MSH2 P43246 L381Q 381 L Q 0.732 Pathogenic MSH2 P43246 L381R 381 L R 0.978 Pathogenic MSH2 P43246 L381S 381 L S 0.646 Pathogenic MSH2 P43246 L381T 381 L T 0.602 Pathogenic MSH2 P43246 L381V 381 L V 0.47 Neutral MSH2 P43246 L381W 381 L W 0.892 Pathogenic MSH2 P43246 L381Y 381 L Y 0.88 Pathogenic MSH2 P43246 R382A 382 R A 0.284 Neutral MSH2 P43246 R382C 382 R C 0.942 Pathogenic MSH2 P43246 R382D 382 R D 0.852 Pathogenic MSH2 P43246 R382E 382 R E 0.826 Pathogenic MSH2 P43246 R382F 382 R F 0.96 Pathogenic MSH2 P43246 R382G 382 R G 0.412 Neutral MSH2 P43246 R382H 382 R H 0.364 Neutral MSH2 P43246 R382I 382 R I 0.968 Pathogenic MSH2 P43246 R382K 382 R K 0.598 Pathogenic MSH2 P43246 R382L 382 R L 0.692 Pathogenic MSH2 P43246 R382M 382 R M 0.79 Pathogenic MSH2 P43246 R382N 382 R N 0.144 Neutral MSH2 P43246 R382P 382 R P 0.396 Neutral MSH2 P43246 R382Q 382 R Q 0.602 Pathogenic MSH2 P43246 R382S 382 R S 0.376 Neutral MSH2 P43246 R382T 382 R T 0.38 Neutral MSH2 P43246 R382V 382 R V 0.67 Pathogenic MSH2 P43246 R382W 382 R W 0.968 Pathogenic MSH2 P43246 R382Y 382 R Y 0.964 Pathogenic MSH2 P43246 R383A 383 R A 0.116 Neutral MSH2 P43246 R383C 383 R C 0.5 Pathogenic MSH2 P43246 R383D 383 R D 0.498 Neutral MSH2 P43246 R383E 383 R E 0.56 Pathogenic MSH2 P43246 R383F 383 R F 0.442 Neutral MSH2 P43246 R383G 383 R G 0.032 Neutral MSH2 P43246 R383H 383 R H 0.45 Neutral MSH2 P43246 R383I 383 R I 0.482 Neutral MSH2 P43246 R383K 383 R K 0.028 Neutral MSH2 P43246 R383L 383 R L 0.112 Neutral MSH2 P43246 R383M 383 R M 0.058 Neutral MSH2 P43246 R383N 383 R N 0.436 Neutral MSH2 P43246 R383P 383 R P 0.846 Pathogenic MSH2 P43246 R383Q 383 R Q 0.058 Neutral MSH2 P43246 R383S 383 R S 0.058 Neutral MSH2 P43246 R383T 383 R T 0.414 Neutral MSH2 P43246 R383V 383 R V 0.654 Pathogenic MSH2 P43246 R383W 383 R W 0.882 Pathogenic MSH2 P43246 R383Y 383 R Y 0.182 Neutral MSH2 P43246 F384A 384 F A 0.29 Neutral MSH2 P43246 F384C 384 F C 0.366 Neutral MSH2 P43246 F384D 384 F D 0.608 Pathogenic MSH2 P43246 F384E 384 F E 0.712 Pathogenic MSH2 P43246 F384G 384 F G 0.376 Neutral MSH2 P43246 F384H 384 F H 0.424 Neutral MSH2 P43246 F384I 384 F I 0.104 Neutral MSH2 P43246 F384K 384 F K 0.468 Neutral MSH2 P43246 F384L 384 F L 0.05 Neutral MSH2 P43246 F384M 384 F M 0.058 Neutral MSH2 P43246 F384N 384 F N 0.582 Pathogenic MSH2 P43246 F384P 384 F P 0.732 Pathogenic MSH2 P43246 F384Q 384 F Q 0.626 Pathogenic MSH2 P43246 F384R 384 F R 0.708 Pathogenic MSH2 P43246 F384S 384 F S 0.372 Neutral MSH2 P43246 F384T 384 F T 0.362 Neutral MSH2 P43246 F384V 384 F V 0.092 Neutral MSH2 P43246 F384W 384 F W 0.812 Pathogenic MSH2 P43246 F384Y 384 F Y 0.478 Neutral MSH2 P43246 P385A 385 P A 0.492 Neutral MSH2 P43246 P385C 385 P C 0.91 Pathogenic MSH2 P43246 P385D 385 P D 0.862 Pathogenic MSH2 P43246 P385E 385 P E 0.956 Pathogenic MSH2 P43246 P385F 385 P F 0.996 Pathogenic MSH2 P43246 P385G 385 P G 0.258 Neutral MSH2 P43246 P385H 385 P H 0.976 Pathogenic MSH2 P43246 P385I 385 P I 0.924 Pathogenic MSH2 P43246 P385K 385 P K 0.946 Pathogenic MSH2 P43246 P385L 385 P L 0.718 Pathogenic MSH2 P43246 P385M 385 P M 0.958 Pathogenic MSH2 P43246 P385N 385 P N 0.782 Pathogenic MSH2 P43246 P385Q 385 P Q 0.59 Pathogenic MSH2 P43246 P385R 385 P R 0.984 Pathogenic MSH2 P43246 P385S 385 P S 0.104 Neutral MSH2 P43246 P385T 385 P T 0.404 Neutral MSH2 P43246 P385V 385 P V 0.836 Pathogenic MSH2 P43246 P385W 385 P W 0.928 Pathogenic MSH2 P43246 P385Y 385 P Y 0.922 Pathogenic MSH2 P43246 D386A 386 D A 0.794 Pathogenic MSH2 P43246 D386C 386 D C 0.89 Pathogenic MSH2 P43246 D386E 386 D E 0.82 Pathogenic MSH2 P43246 D386F 386 D F 0.978 Pathogenic MSH2 P43246 D386G 386 D G 0.956 Pathogenic MSH2 P43246 D386H 386 D H 0.638 Pathogenic MSH2 P43246 D386I 386 D I 0.876 Pathogenic MSH2 P43246 D386K 386 D K 0.928 Pathogenic MSH2 P43246 D386L 386 D L 0.978 Pathogenic MSH2 P43246 D386M 386 D M 0.956 Pathogenic MSH2 P43246 D386N 386 D N 0.514 Pathogenic MSH2 P43246 D386P 386 D P 0.91 Pathogenic MSH2 P43246 D386Q 386 D Q 0.64 Pathogenic MSH2 P43246 D386R 386 D R 0.958 Pathogenic MSH2 P43246 D386S 386 D S 0.594 Pathogenic MSH2 P43246 D386T 386 D T 0.808 Pathogenic MSH2 P43246 D386V 386 D V 0.992 Pathogenic MSH2 P43246 D386W 386 D W 0.982 Pathogenic MSH2 P43246 D386Y 386 D Y 0.936 Pathogenic MSH2 P43246 L387A 387 L A 0.57 Pathogenic MSH2 P43246 L387C 387 L C 0.698 Pathogenic MSH2 P43246 L387D 387 L D 0.91 Pathogenic MSH2 P43246 L387E 387 L E 0.888 Pathogenic MSH2 P43246 L387F 387 L F 0.442 Neutral MSH2 P43246 L387G 387 L G 0.462 Neutral MSH2 P43246 L387H 387 L H 0.806 Pathogenic MSH2 P43246 L387I 387 L I 0.134 Neutral MSH2 P43246 L387K 387 L K 0.152 Neutral MSH2 P43246 L387M 387 L M 0.16 Neutral MSH2 P43246 L387N 387 L N 0.78 Pathogenic MSH2 P43246 L387P 387 L P 0.994 Pathogenic MSH2 P43246 L387Q 387 L Q 0.624 Pathogenic MSH2 P43246 L387R 387 L R 0.996 Pathogenic MSH2 P43246 L387S 387 L S 0.616 Pathogenic MSH2 P43246 L387T 387 L T 0.594 Pathogenic MSH2 P43246 L387V 387 L V 0.092 Neutral MSH2 P43246 L387W 387 L W 0.928 Pathogenic MSH2 P43246 L387Y 387 L Y 0.736 Pathogenic MSH2 P43246 N388A 388 N A 0.414 Neutral MSH2 P43246 N388C 388 N C 0.558 Pathogenic MSH2 P43246 N388D 388 N D 0.034 Neutral MSH2 P43246 N388E 388 N E 0.038 Neutral MSH2 P43246 N388F 388 N F 0.462 Neutral MSH2 P43246 N388G 388 N G 0.582 Pathogenic MSH2 P43246 N388H 388 N H 0.058 Neutral MSH2 P43246 N388I 388 N I 0.828 Pathogenic MSH2 P43246 N388K 388 N K 0.754 Pathogenic MSH2 P43246 N388L 388 N L 0.148 Neutral MSH2 P43246 N388M 388 N M 0.424 Neutral MSH2 P43246 N388P 388 N P 0.804 Pathogenic MSH2 P43246 N388Q 388 N Q 0.016 Neutral MSH2 P43246 N388R 388 N R 0.412 Neutral MSH2 P43246 N388S 388 N S 0.034 Neutral MSH2 P43246 N388T 388 N T 0.042 Neutral MSH2 P43246 N388V 388 N V 0.858 Pathogenic MSH2 P43246 N388W 388 N W 0.928 Pathogenic MSH2 P43246 N388Y 388 N Y 0.674 Pathogenic MSH2 P43246 R389A 389 R A 0.304 Neutral MSH2 P43246 R389C 389 R C 0.934 Pathogenic MSH2 P43246 R389D 389 R D 0.24 Neutral MSH2 P43246 R389E 389 R E 0.742 Pathogenic MSH2 P43246 R389F 389 R F 0.748 Pathogenic MSH2 P43246 R389G 389 R G 0.39 Neutral MSH2 P43246 R389H 389 R H 0.318 Neutral MSH2 P43246 R389I 389 R I 0.702 Pathogenic MSH2 P43246 R389K 389 R K 0.304 Neutral MSH2 P43246 R389L 389 R L 0.382 Neutral MSH2 P43246 R389M 389 R M 0.21 Neutral MSH2 P43246 R389N 389 R N 0.576 Pathogenic MSH2 P43246 R389P 389 R P 0.978 Pathogenic MSH2 P43246 R389Q 389 R Q 0.068 Neutral MSH2 P43246 R389S 389 R S 0.882 Pathogenic MSH2 P43246 R389T 389 R T 0.906 Pathogenic MSH2 P43246 R389V 389 R V 0.35 Neutral MSH2 P43246 R389W 389 R W 0.944 Pathogenic MSH2 P43246 R389Y 389 R Y 0.946 Pathogenic MSH2 P43246 R39A 39 R A 0.586 Pathogenic MSH2 P43246 R39C 39 R C 0.968 Pathogenic MSH2 P43246 R39D 39 R D 0.772 Pathogenic MSH2 P43246 R39E 39 R E 0.806 Pathogenic MSH2 P43246 R39F 39 R F 0.976 Pathogenic MSH2 P43246 R39G 39 R G 0.436 Neutral MSH2 P43246 R39H 39 R H 0.112 Neutral MSH2 P43246 R39I 39 R I 0.704 Pathogenic MSH2 P43246 R39K 39 R K 0.332 Neutral MSH2 P43246 R39L 39 R L 0.988 Pathogenic MSH2 P43246 R39M 39 R M 0.78 Pathogenic MSH2 P43246 R39N 39 R N 0.7 Pathogenic MSH2 P43246 R39P 39 R P 0.988 Pathogenic MSH2 P43246 R39Q 39 R Q 0.088 Neutral MSH2 P43246 R39S 39 R S 0.936 Pathogenic MSH2 P43246 R39T 39 R T 0.948 Pathogenic MSH2 P43246 R39V 39 R V 0.98 Pathogenic MSH2 P43246 R39W 39 R W 0.958 Pathogenic MSH2 P43246 R39Y 39 R Y 0.966 Pathogenic MSH2 P43246 L390A 390 L A 0.306 Neutral MSH2 P43246 L390C 390 L C 0.806 Pathogenic MSH2 P43246 L390D 390 L D 0.876 Pathogenic MSH2 P43246 L390E 390 L E 0.858 Pathogenic MSH2 P43246 L390F 390 L F 0.628 Pathogenic 1 MSH2 P43246 L390G 390 L G 0.846 Pathogenic MSH2 P43246 L390H 390 L H 0.898 Pathogenic MSH2 P43246 L390I 390 L I 0.23 Neutral MSH2 P43246 L390K 390 L K 0.674 Pathogenic MSH2 P43246 L390M 390 L M 0.228 Neutral MSH2 P43246 L390N 390 L N 0.784 Pathogenic MSH2 P43246 L390P 390 L P 0.97 Pathogenic MSH2 P43246 L390Q 390 L Q 0.748 Pathogenic MSH2 P43246 L390R 390 L R 0.97 Pathogenic MSH2 P43246 L390S 390 L S 0.656 Pathogenic MSH2 P43246 L390T 390 L T 0.576 Pathogenic MSH2 P43246 L390V 390 L V 0.156 Neutral MSH2 P43246 L390W 390 L W 0.848 Pathogenic MSH2 P43246 L390Y 390 L Y 0.87 Pathogenic MSH2 P43246 A391C 391 A C 0.176 Neutral MSH2 P43246 A391D 391 A D 0.84 Pathogenic MSH2 P43246 A391E 391 A E 0.586 Pathogenic MSH2 P43246 A391F 391 A F 0.956 Pathogenic MSH2 P43246 A391G 391 A G 0.02 Neutral MSH2 P43246 A391H 391 A H 0.85 Pathogenic MSH2 P43246 A391I 391 A I 0.764 Pathogenic MSH2 P43246 A391K 391 A K 0.896 Pathogenic MSH2 P43246 A391L 391 A L 0.57 Pathogenic MSH2 P43246 A391M 391 A M 0.548 Pathogenic MSH2 P43246 A391N 391 A N 0.722 Pathogenic MSH2 P43246 A391P 391 A P 0.826 Pathogenic MSH2 P43246 A391Q 391 A Q 0.78 Pathogenic MSH2 P43246 A391R 391 A R 0.904 Pathogenic MSH2 P43246 A391S 391 A S 0.014 Neutral MSH2 P43246 A391T 391 A T 0.036 Neutral MSH2 P43246 A391V 391 A V 0.144 Neutral MSH2 P43246 A391W 391 A W 0.948 Pathogenic MSH2 P43246 A391Y 391 A Y 0.918 Pathogenic MSH2 P43246 K392A 392 K A 0.694 Pathogenic MSH2 P43246 K392C 392 K C 0.568 Pathogenic MSH2 P43246 K392D 392 K D 0.76 Pathogenic MSH2 P43246 K392E 392 K E 0.236 Neutral MSH2 P43246 K392F 392 K F 0.94 Pathogenic MSH2 P43246 K392G 392 K G 0.536 Pathogenic MSH2 P43246 K392H 392 K H 0.202 Neutral MSH2 P43246 K392I 392 K I 0.974 Pathogenic MSH2 P43246 K392L 392 K L 0.966 Pathogenic MSH2 P43246 K392M 392 K M 0.414 Neutral MSH2 P43246 K392N 392 K N 0.26 Neutral MSH2 P43246 K392P 392 K P 0.904 Pathogenic MSH2 P43246 K392Q 392 K Q 0.848 Pathogenic MSH2 P43246 K392R 392 K R 0.228 Neutral MSH2 P43246 K392S 392 K S 0.276 Neutral MSH2 P43246 K392T 392 K T 0.632 Pathogenic MSH2 P43246 K392V 392 K V 0.844 Pathogenic MSH2 P43246 K392W 392 K W 0.758 Pathogenic MSH2 P43246 K392Y 392 K Y 0.962 Pathogenic MSH2 P43246 K393A 393 K A 0.19 Neutral MSH2 P43246 K393C 393 K C 0.474 Neutral MSH2 P43246 K393D 393 K D 0.666 Pathogenic MSH2 P43246 K393E 393 K E 0.788 Pathogenic MSH2 P43246 K393F 393 K F 0.95 Pathogenic MSH2 P43246 K393G 393 K G 0.518 Pathogenic MSH2 P43246 K393H 393 K H 0.796 Pathogenic MSH2 P43246 K393I 393 K I 0.736 Pathogenic MSH2 P43246 K393L 393 K L 0.96 Pathogenic MSH2 P43246 K393M 393 K M 0.898 Pathogenic MSH2 P43246 K393N 393 K N 0.156 Neutral MSH2 P43246 K393P 393 K P 0.904 Pathogenic MSH2 P43246 K393Q 393 K Q 0.792 Pathogenic MSH2 P43246 K393R 393 K R 0.138 Neutral MSH2 P43246 K393S 393 K S 0.15 Neutral MSH2 P43246 K393T 393 K T 0.302 Neutral MSH2 P43246 K393V 393 K V 0.862 Pathogenic MSH2 P43246 K393W 393 K W 0.984 Pathogenic MSH2 P43246 K393Y 393 K Y 0.894 Pathogenic MSH2 P43246 F394A 394 F A 0.512 Pathogenic MSH2 P43246 F394C 394 F C 0.72 Pathogenic MSH2 P43246 F394D 394 F D 0.802 Pathogenic MSH2 P43246 F394E 394 F E 0.85 Pathogenic MSH2 P43246 F394G 394 F G 0.512 Pathogenic MSH2 P43246 F394H 394 F H 0.76 Pathogenic MSH2 P43246 F394I 394 F I 0.192 Neutral MSH2 P43246 F394K 394 F K 0.838 Pathogenic MSH2 P43246 F394L 394 F L 0.164 Neutral MSH2 P43246 F394M 394 F M 0.78 Pathogenic MSH2 P43246 F394N 394 F N 0.74 Pathogenic MSH2 P43246 F394P 394 F P 0.966 Pathogenic MSH2 P43246 F394Q 394 F Q 0.752 Pathogenic MSH2 P43246 F394R 394 F R 0.902 Pathogenic MSH2 P43246 F394S 394 F S 0.864 Pathogenic MSH2 P43246 F394T 394 F T 0.592 Pathogenic MSH2 P43246 F394V 394 F V 0.224 Neutral MSH2 P43246 F394W 394 F W 0.868 Pathogenic MSH2 P43246 F394Y 394 F Y 0.434 Neutral MSH2 P43246 Q395A 395 Q A 0.132 Neutral MSH2 P43246 Q395C 395 Q C 0.492 Neutral MSH2 P43246 Q395D 395 Q D 0.552 Pathogenic MSH2 P43246 Q395E 395 Q E 0.022 Neutral MSH2 P43246 Q395F 395 Q F 0.816 Pathogenic MSH2 P43246 Q395G 395 Q G 0.364 Neutral MSH2 P43246 Q395H 395 Q H 0.082 Neutral MSH2 P43246 Q395I 395 Q I 0.352 Neutral MSH2 P43246 Q395K 395 Q K 0.072 Neutral MSH2 P43246 Q395L 395 Q L 0.224 Neutral MSH2 P43246 Q395M 395 Q M 0.082 Neutral MSH2 P43246 Q395N 395 Q N 0.096 Neutral MSH2 P43246 Q395P 395 Q P 0.766 Pathogenic MSH2 P43246 Q395R 395 Q R 0.102 Neutral MSH2 P43246 Q395S 395 Q S 0.1 Neutral MSH2 P43246 Q395T 395 Q T 0.406 Neutral MSH2 P43246 Q395V 395 Q V 0.204 Neutral MSH2 P43246 Q395W 395 Q W 0.906 Pathogenic MSH2 P43246 Q395Y 395 Q Y 0.868 Pathogenic MSH2 P43246 R396A 396 R A 0.306 Neutral MSH2 P43246 R396C 396 R C 0.55 Pathogenic MSH2 P43246 R396D 396 R D 0.564 Pathogenic MSH2 P43246 R396E 396 R E 0.476 Neutral MSH2 P43246 R396F 396 R F 0.744 Pathogenic MSH2 P43246 R396G 396 R G 0.252 Neutral MSH2 P43246 R396H 396 R H 0.502 Pathogenic MSH2 P43246 R396I 396 R I 0.766 Pathogenic MSH2 P43246 R396K 396 R K 0.048 Neutral MSH2 P43246 R396L 396 R L 0.706 Pathogenic MSH2 P43246 R396M 396 R M 0.54 Pathogenic MSH2 P43246 R396N 396 R N 0.62 Pathogenic MSH2 P43246 R396P 396 R P 0.686 Pathogenic MSH2 P43246 R396Q 396 R Q 0.126 Neutral MSH2 P43246 R396S 396 R S 0.236 Neutral MSH2 P43246 R396T 396 R T 0.488 Neutral MSH2 P43246 R396V 396 R V 0.684 Pathogenic MSH2 P43246 R396W 396 R W 0.778 Pathogenic MSH2 P43246 R396Y 396 R Y 0.71 Pathogenic MSH2 P43246 Q397A 397 Q A 0.12 Neutral MSH2 P43246 Q397C 397 Q C 0.366 Neutral MSH2 P43246 Q397D 397 Q D 0.434 Neutral MSH2 P43246 Q397E 397 Q E 0.6 Pathogenic MSH2 P43246 Q397F 397 Q F 0.78 Pathogenic MSH2 P43246 Q397G 397 Q G 0.1 Neutral MSH2 P43246 Q397H 397 Q H 0.086 Neutral MSH2 P43246 Q397I 397 Q I 0.352 Neutral MSH2 P43246 Q397K 397 Q K 0.05 Neutral MSH2 P43246 Q397L 397 Q L 0.194 Neutral MSH2 P43246 Q397M 397 Q M 0.078 Neutral MSH2 P43246 Q397N 397 Q N 0.098 Neutral MSH2 P43246 Q397P 397 Q P 0.838 Pathogenic MSH2 P43246 Q397R 397 Q R 0.056 Neutral MSH2 P43246 Q397S 397 Q S 0.1 Neutral MSH2 P43246 Q397T 397 Q T 0.052 Neutral MSH2 P43246 Q397V 397 Q V 0.088 Neutral MSH2 P43246 Q397W 397 Q W 0.896 Pathogenic MSH2 P43246 Q397Y 397 Q Y 0.908 Pathogenic MSH2 P43246 A398C 398 A C 0.972 Pathogenic MSH2 P43246 A398D 398 A D 0.802 Pathogenic MSH2 P43246 A398E 398 A E 0.748 Pathogenic MSH2 P43246 A398F 398 A F 0.996 Pathogenic MSH2 P43246 A398G 398 A G 0.114 Neutral MSH2 P43246 A398H 398 A H 0.936 Pathogenic MSH2 P43246 A398I 398 A I 0.958 Pathogenic MSH2 P43246 A398K 398 A K 0.64 Pathogenic MSH2 P43246 A398L 398 A L 1 Pathogenic MSH2 P43246 A398M 398 A M 0.902 Pathogenic MSH2 P43246 A398N 398 A N 0.56 Pathogenic MSH2 P43246 A398P 398 A P 0.974 Pathogenic MSH2 P43246 A398Q 398 A Q 0.902 Pathogenic MSH2 P43246 A398R 398 A R 0.624 Pathogenic MSH2 P43246 A398S 398 A S 0.136 Neutral MSH2 P43246 A398T 398 A T 0.2 Neutral MSH2 P43246 A398V 398 A V 0.52 Pathogenic MSH2 P43246 A398W 398 A W 0.996 Pathogenic MSH2 P43246 A398Y 398 A Y 0.916 Pathogenic MSH2 P43246 A399C 399 A C 0.732 Pathogenic MSH2 P43246 A399D 399 A D 0.754 Pathogenic MSH2 P43246 A399E 399 A E 0.862 Pathogenic MSH2 P43246 A399F 399 A F 0.958 Pathogenic MSH2 P43246 A399G 399 A G 0.016 Neutral MSH2 P43246 A399H 399 A H 0.852 Pathogenic MSH2 P43246 A399I 399 A I 0.924 Pathogenic MSH2 P43246 A399K 399 A K 0.898 Pathogenic MSH2 P43246 A399L 399 A L 0.73 Pathogenic MSH2 P43246 A399M 399 A M 0.786 Pathogenic MSH2 P43246 A399N 399 A N 0.58 Pathogenic MSH2 P43246 A399P 399 A P 0.928 Pathogenic MSH2 P43246 A399Q 399 A Q 0.704 Pathogenic MSH2 P43246 A399R 399 A R 0.868 Pathogenic MSH2 P43246 A399S 399 A S 0.008 Neutral MSH2 P43246 A399T 399 A T 0.036 Neutral MSH2 P43246 A399V 399 A V 0.75 Pathogenic MSH2 P43246 A399W 399 A W 0.95 Pathogenic MSH2 P43246 A399Y 399 A Y 0.932 Pathogenic MSH2 P43246 Q4A 4 Q A 0.08 Neutral MSH2 P43246 Q4C 4 Q C 0.082 Neutral MSH2 P43246 Q4D 4 Q D 0.054 Neutral MSH2 P43246 Q4E 4 Q E 0.008 Neutral MSH2 P43246 Q4F 4 Q F 0.274 Neutral MSH2 P43246 Q4G 4 Q G 0.118 Neutral MSH2 P43246 Q4H 4 Q H 0.266 Neutral MSH2 P43246 Q4I 4 Q I 0.292 Neutral MSH2 P43246 Q4K 4 Q K 0.054 Neutral MSH2 P43246 Q4L 4 Q L 0.34 Neutral MSH2 P43246 Q4M 4 Q M 0.19 Neutral MSH2 P43246 Q4N 4 Q N 0.094 Neutral MSH2 P43246 Q4P 4 Q P 0.246 Neutral MSH2 P43246 Q4R 4 Q R 0.026 Neutral MSH2 P43246 Q4S 4 Q S 0.186 Neutral MSH2 P43246 Q4T 4 Q T 0.132 Neutral MSH2 P43246 Q4V 4 Q V 0.28 Neutral MSH2 P43246 Q4W 4 Q W 0.458 Neutral MSH2 P43246 Q4Y 4 Q Y 0.394 Neutral MSH2 P43246 G40A 40 G A 0.118 Neutral MSH2 P43246 G40C 40 G C 0.302 Neutral MSH2 P43246 G40D 40 G D 0.384 Neutral MSH2 P43246 G40E 40 G E 0.28 Neutral MSH2 P43246 G40F 40 G F 0.678 Pathogenic MSH2 P43246 G40H 40 G H 0.536 Pathogenic MSH2 P43246 G40I 40 G I 0.606 Pathogenic MSH2 P43246 G40K 40 G K 0.37 Neutral MSH2 P43246 G40L 40 G L 0.598 Pathogenic MSH2 P43246 G40M 40 G M 0.612 Pathogenic MSH2 P43246 G40N 40 G N 0.248 Neutral MSH2 P43246 G40P 40 G P 0.56 Pathogenic MSH2 P43246 G40Q 40 G Q 0.274 Neutral MSH2 P43246 G40R 40 G R 0.392 Neutral MSH2 P43246 G40S 40 G S 0.024 Neutral MSH2 P43246 G40T 40 G T 0.344 Neutral MSH2 P43246 G40V 40 G V 0.572 Pathogenic MSH2 P43246 G40W 40 G W 0.676 Pathogenic MSH2 P43246 G40Y 40 G Y 0.636 Pathogenic MSH2 P43246 N400A 400 N A 0.028 Neutral MSH2 P43246 N400C 400 N C 0.25 Neutral MSH2 P43246 N400D 400 N D 0.15 Neutral MSH2 P43246 N400E 400 N E 0.166 Neutral MSH2 P43246 N400F 400 N F 0.594 Pathogenic MSH2 P43246 N400G 400 N G 0.052 Neutral MSH2 P43246 N400H 400 N H 0.41 Neutral MSH2 P43246 N400I 400 N I 0.44 Neutral MSH2 P43246 N400K 400 N K 0.192 Neutral MSH2 P43246 N400L 400 N L 0.444 Neutral MSH2 P43246 N400M 400 N M 0.376 Neutral MSH2 P43246 N400P 400 N P 0.4 Neutral MSH2 P43246 N400Q 400 N Q 0.246 Neutral MSH2 P43246 N400R 400 N R 0.316 Neutral MSH2 P43246 N400S 400 N S 0.004 Neutral MSH2 P43246 N400T 400 N T 0.008 Neutral MSH2 P43246 N400V 400 N V 0.43 Neutral MSH2 P43246 N400W 400 N W 0.724 Pathogenic MSH2 P43246 N400Y 400 N Y 0.678 Pathogenic MSH2 P43246 L401A 401 L A 0.716 Pathogenic MSH2 P43246 L401C 401 L C 0.83 Pathogenic MSH2 P43246 L401D 401 L D 0.912 Pathogenic MSH2 P43246 L401E 401 L E 0.894 Pathogenic MSH2 P43246 L401F 401 L F 0.884 Pathogenic MSH2 P43246 L401G 401 L G 0.862 Pathogenic MSH2 P43246 L401H 401 L H 0.908 Pathogenic MSH2 P43246 L401I 401 L I 0.94 Pathogenic MSH2 P43246 L401K 401 L K 0.732 Pathogenic MSH2 P43246 L401M 401 L M 0.39 Neutral MSH2 P43246 L401N 401 L N 0.822 Pathogenic MSH2 P43246 L401P 401 L P 0.986 Pathogenic MSH2 P43246 L401Q 401 L Q 0.778 Pathogenic MSH2 P43246 L401R 401 L R 0.982 Pathogenic MSH2 P43246 L401S 401 L S 0.506 Pathogenic MSH2 P43246 L401T 401 L T 0.636 Pathogenic MSH2 P43246 L401V 401 L V 0.456 Neutral MSH2 P43246 L401W 401 L W 0.886 Pathogenic MSH2 P43246 L401Y 401 L Y 0.896 Pathogenic MSH2 P43246 Q402A 402 Q A 0.392 Neutral MSH2 P43246 Q402C 402 Q C 0.67 Pathogenic MSH2 P43246 Q402D 402 Q D 0.284 Neutral MSH2 P43246 Q402E 402 Q E 0.348 Neutral MSH2 P43246 Q402F 402 Q F 0.894 Pathogenic MSH2 P43246 Q402G 402 Q G 0.568 Pathogenic MSH2 P43246 Q402H 402 Q H 0.462 Neutral MSH2 P43246 Q402I 402 Q I 0.948 Pathogenic MSH2 P43246 Q402K 402 Q K 0.518 Pathogenic MSH2 P43246 Q402L 402 Q L 0.764 Pathogenic MSH2 P43246 Q402M 402 Q M 0.398 Neutral MSH2 P43246 Q402N 402 Q N 0.778 Pathogenic MSH2 P43246 Q402P 402 Q P 0.914 Pathogenic MSH2 P43246 Q402R 402 Q R 0.578 Pathogenic MSH2 P43246 Q402S 402 Q S 0.842 Pathogenic MSH2 P43246 Q402T 402 Q T 0.664 Pathogenic MSH2 P43246 Q402V 402 Q V 0.376 Neutral MSH2 P43246 Q402W 402 Q W 0.96 Pathogenic MSH2 P43246 Q402Y 402 Q Y 0.808 Pathogenic MSH2 P43246 D403A 403 D A 0.768 Pathogenic MSH2 P43246 D403C 403 D C 0.848 Pathogenic MSH2 P43246 D403E 403 D E 0.292 Neutral MSH2 P43246 D403F 403 D F 0.966 Pathogenic MSH2 P43246 D403G 403 D G 0.386 Neutral MSH2 P43246 D403H 403 D H 0.316 Neutral MSH2 P43246 D403I 403 D I 0.958 Pathogenic MSH2 P43246 D403K 403 D K 0.868 Pathogenic MSH2 P43246 D403L 403 D L 0.958 Pathogenic MSH2 P43246 D403M 403 D M 0.936 Pathogenic MSH2 P43246 D403N 403 D N 0.23 Neutral MSH2 P43246 D403P 403 D P 0.386 Neutral MSH2 P43246 D403Q 403 D Q 0.29 Neutral MSH2 P43246 D403R 403 D R 0.944 Pathogenic MSH2 P43246 D403S 403 D S 0.506 Pathogenic MSH2 P43246 D403T 403 D T 0.752 Pathogenic MSH2 P43246 D403V 403 D V 0.978 Pathogenic MSH2 P43246 D403W 403 D W 0.972 Pathogenic MSH2 P43246 D403Y 403 D Y 0.962 Pathogenic MSH2 P43246 C404A 404 C A 0.594 Pathogenic MSH2 P43246 C404D 404 C D 0.872 Pathogenic MSH2 P43246 C404E 404 C E 0.892 Pathogenic MSH2 P43246 C404F 404 C F 0.998 Pathogenic MSH2 P43246 C404G 404 C G 0.888 Pathogenic MSH2 P43246 C404H 404 C H 0.9 Pathogenic MSH2 P43246 C404I 404 C I 0.374 Neutral MSH2 P43246 C404K 404 C K 0.876 Pathogenic MSH2 P43246 C404L 404 C L 0.37 Neutral MSH2 P43246 C404M 404 C M 0.5 Pathogenic MSH2 P43246 C404N 404 C N 0.688 Pathogenic MSH2 P43246 C404P 404 C P 0.976 Pathogenic MSH2 P43246 C404Q 404 C Q 0.744 Pathogenic MSH2 P43246 C404R 404 C R 0.73 Pathogenic MSH2 P43246 C404S 404 C S 0.114 Neutral MSH2 P43246 C404T 404 C T 0.8 Pathogenic MSH2 P43246 C404V 404 C V 0.39 Neutral MSH2 P43246 C404W 404 C W 0.996 Pathogenic MSH2 P43246 C404Y 404 C Y 0.994 Pathogenic MSH2 P43246 Y405A 405 Y A 0.33 Neutral MSH2 P43246 Y405C 405 Y C 0.164 Neutral MSH2 P43246 Y405D 405 Y D 0.79 Pathogenic MSH2 P43246 Y405E 405 Y E 0.708 Pathogenic MSH2 P43246 Y405F 405 Y F 0.078 Neutral MSH2 P43246 Y405G 405 Y G 0.378 Neutral MSH2 P43246 Y405H 405 Y H 0.188 Neutral MSH2 P43246 Y405I 405 Y I 0.162 Neutral MSH2 P43246 Y405K 405 Y K 0.804 Pathogenic MSH2 P43246 Y405L 405 Y L 0.124 Neutral MSH2 P43246 Y405M 405 Y M 0.582 Pathogenic MSH2 P43246 Y405N 405 Y N 0.614 Pathogenic MSH2 P43246 Y405P 405 Y P 0.702 Pathogenic MSH2 P43246 Y405Q 405 Y Q 0.526 Pathogenic MSH2 P43246 Y405R 405 Y R 0.74 Pathogenic MSH2 P43246 Y405S 405 Y S 0.374 Neutral MSH2 P43246 Y405T 405 Y T 0.534 Pathogenic MSH2 P43246 Y405V 405 Y V 0.296 Neutral MSH2 P43246 Y405W 405 Y W 0.79 Pathogenic MSH2 P43246 R406A 406 R A 0.586 Pathogenic MSH2 P43246 R406C 406 R C 0.966 Pathogenic MSH2 P43246 R406D 406 R D 0.782 Pathogenic MSH2 P43246 R406E 406 R E 0.812 Pathogenic MSH2 P43246 R406F 406 R F 0.976 Pathogenic MSH2 P43246 R406G 406 R G 0.438 Neutral MSH2 P43246 R406H 406 R H 0.456 Neutral MSH2 P43246 R406I 406 R I 0.704 Pathogenic MSH2 P43246 R406K 406 R K 0.338 Neutral MSH2 P43246 R406L 406 R L 0.99 Pathogenic MSH2 P43246 R406M 406 R M 0.464 Neutral MSH2 P43246 R406N 406 R N 0.11 Neutral MSH2 P43246 R406P 406 R P 0.99 Pathogenic MSH2 P43246 R406Q 406 R Q 0.072 Neutral MSH2 P43246 R406S 406 R S 0.352 Neutral MSH2 P43246 R406T 406 R T 0.948 Pathogenic MSH2 P43246 R406V 406 R V 0.646 Pathogenic MSH2 P43246 R406W 406 R W 0.968 Pathogenic MSH2 P43246 R406Y 406 R Y 0.974 Pathogenic MSH2 P43246 L407A 407 L A 0.038 Neutral MSH2 P43246 L407C 407 L C 0.164 Neutral MSH2 P43246 L407D 407 L D 0.662 Pathogenic MSH2 P43246 L407E 407 L E 0.622 Pathogenic MSH2 P43246 L407F 407 L F 0.758 Pathogenic MSH2 P43246 L407G 407 L G 0.57 Pathogenic MSH2 P43246 L407H 407 L H 0.444 Neutral MSH2 P43246 L407I 407 L I 0.044 Neutral MSH2 P43246 L407K 407 L K 0.366 Neutral MSH2 P43246 L407M 407 L M 0.02 Neutral MSH2 P43246 L407N 407 L N 0.462 Neutral MSH2 P43246 L407P 407 L P 0.896 Pathogenic MSH2 P43246 L407Q 407 L Q 0.382 Neutral MSH2 P43246 L407R 407 L R 0.858 Pathogenic MSH2 P43246 L407S 407 L S 0.354 Neutral MSH2 P43246 L407T 407 L T 0.03 Neutral MSH2 P43246 L407V 407 L V 0.05 Neutral MSH2 P43246 L407W 407 L W 0.82 Pathogenic MSH2 P43246 L407Y 407 L Y 0.806 Pathogenic MSH2 P43246 Y408A 408 Y A 0.432 Neutral MSH2 P43246 Y408C 408 Y C 0.69 Pathogenic MSH2 P43246 Y408D 408 Y D 0.846 Pathogenic MSH2 P43246 Y408E 408 Y E 0.592 Pathogenic MSH2 P43246 Y408F 408 Y F 0.406 Neutral MSH2 P43246 Y408G 408 Y G 0.48 Neutral MSH2 P43246 Y408H 408 Y H 0.434 Neutral MSH2 P43246 Y408I 408 Y I 0.804 Pathogenic MSH2 P43246 Y408K 408 Y K 0.588 Pathogenic MSH2 P43246 Y408L 408 Y L 0.712 Pathogenic MSH2 P43246 Y408M 408 Y M 0.69 Pathogenic MSH2 P43246 Y408N 408 Y N 0.746 Pathogenic MSH2 P43246 Y408P 408 Y P 0.786 Pathogenic MSH2 P43246 Y408Q 408 Y Q 0.666 Pathogenic MSH2 P43246 Y408R 408 Y R 0.786 Pathogenic MSH2 P43246 Y408S 408 Y S 0.396 Neutral MSH2 P43246 Y408T 408 Y T 0.686 Pathogenic MSH2 P43246 Y408V 408 Y V 0.662 Pathogenic MSH2 P43246 Y408W 408 Y W 0.662 Pathogenic MSH2 P43246 Q409A 409 Q A 0.78 Pathogenic MSH2 P43246 Q409C 409 Q C 0.36 Neutral MSH2 P43246 Q409D 409 Q D 0.246 Neutral MSH2 P43246 Q409E 409 Q E 0.478 Neutral MSH2 P43246 Q409F 409 Q F 0.904 Pathogenic MSH2 P43246 Q409G 409 Q G 0.202 Neutral MSH2 P43246 Q409H 409 Q H 0.882 Pathogenic MSH2 P43246 Q409I 409 Q I 0.934 Pathogenic MSH2 P43246 Q409K 409 Q K 0.468 Neutral MSH2 P43246 Q409L 409 Q L 0.424 Neutral MSH2 P43246 Q409M 409 Q M 0.322 Neutral MSH2 P43246 Q409N 409 Q N 0.884 Pathogenic MSH2 P43246 Q409P 409 Q P 0.898 Pathogenic MSH2 P43246 Q409R 409 Q R 0.506 Pathogenic MSH2 P43246 Q409S 409 Q S 0.624 Pathogenic MSH2 P43246 Q409T 409 Q T 0.24 Neutral MSH2 P43246 Q409V 409 Q V 0.908 Pathogenic MSH2 P43246 Q409W 409 Q W 0.942 Pathogenic MSH2 P43246 Q409Y 409 Q Y 0.792 Pathogenic MSH2 P43246 D41A 41 D A 0.706 Pathogenic MSH2 P43246 D41C 41 D C 0.886 Pathogenic MSH2 P43246 D41E 41 D E 0.218 Neutral MSH2 P43246 D41F 41 D F 0.972 Pathogenic MSH2 P43246 D41G 41 D G 0.174 Neutral MSH2 P43246 D41H 41 D H 0.616 Pathogenic MSH2 P43246 D41I 41 D I 0.95 Pathogenic MSH2 P43246 D41K 41 D K 0.954 Pathogenic MSH2 P43246 D41L 41 D L 0.956 Pathogenic MSH2 P43246 D41M 41 D M 0.936 Pathogenic MSH2 P43246 D41N 41 D N 0.178 Neutral MSH2 P43246 D41P 41 D P 0.89 Pathogenic MSH2 P43246 D41Q 41 D Q 0.736 Pathogenic MSH2 P43246 D41R 41 D R 0.912 Pathogenic MSH2 P43246 D41S 41 D S 0.166 Neutral MSH2 P43246 D41T 41 D T 0.81 Pathogenic MSH2 P43246 D41V 41 D V 0.77 Pathogenic MSH2 P43246 D41W 41 D W 0.978 Pathogenic MSH2 P43246 D41Y 41 D Y 0.972 Pathogenic MSH2 P43246 G410A 410 G A 0.068 Neutral MSH2 P43246 G410C 410 G C 0.53 Pathogenic MSH2 P43246 G410D 410 G D 0.846 Pathogenic MSH2 P43246 G410E 410 G E 0.824 Pathogenic MSH2 P43246 G410F 410 G F 0.666 Pathogenic MSH2 P43246 G410H 410 G H 0.966 Pathogenic MSH2 P43246 G410I 410 G I 0.742 Pathogenic MSH2 P43246 G410K 410 G K 0.972 Pathogenic MSH2 P43246 G410L 410 G L 0.678 Pathogenic MSH2 P43246 G410M 410 G M 0.65 Pathogenic MSH2 P43246 G410N 410 G N 0.816 Pathogenic MSH2 P43246 G410P 410 G P 0.93 Pathogenic MSH2 P43246 G410Q 410 G Q 0.866 Pathogenic MSH2 P43246 G410R 410 G R 0.986 Pathogenic MSH2 P43246 G410S 410 G S 0.082 Neutral MSH2 P43246 G410T 410 G T 0.686 Pathogenic MSH2 P43246 G410V 410 G V 0.628 Pathogenic MSH2 P43246 G410W 410 G W 0.956 Pathogenic MSH2 P43246 G410Y 410 G Y 0.948 Pathogenic MSH2 P43246 I411A 411 I A 0.048 Neutral MSH2 P43246 I411C 411 I C 0.052 Neutral MSH2 P43246 I411D 411 I D 0.624 Pathogenic MSH2 P43246 I411E 411 I E 0.608 Pathogenic MSH2 P43246 I411F 411 I F 0.686 Pathogenic MSH2 P43246 I411G 411 I G 0.486 Neutral MSH2 P43246 I411H 411 I H 0.508 Pathogenic MSH2 P43246 I411K 411 I K 0.616 Pathogenic MSH2 P43246 I411L 411 I L 0.016 Neutral MSH2 P43246 I411M 411 I M 0.064 Neutral MSH2 P43246 I411N 411 I N 0.666 Pathogenic MSH2 P43246 I411P 411 I P 0.75 Pathogenic MSH2 P43246 I411Q 411 I Q 0.642 Pathogenic MSH2 P43246 I411R 411 I R 0.822 Pathogenic MSH2 P43246 I411S 411 I S 0.096 Neutral MSH2 P43246 I411T 411 I T 0.022 Neutral MSH2 P43246 I411V 411 I V 0.154 Neutral MSH2 P43246 I411W 411 I W 0.87 Pathogenic MSH2 P43246 I411Y 411 I Y 0.806 Pathogenic MSH2 P43246 N412A 412 N A 0.128 Neutral MSH2 P43246 N412C 412 N C 0.582 Pathogenic MSH2 P43246 N412D 412 N D 0.064 Neutral MSH2 P43246 N412E 412 N E 0.1 Neutral MSH2 P43246 N412F 412 N F 0.908 Pathogenic MSH2 P43246 N412G 412 N G 0.106 Neutral MSH2 P43246 N412H 412 N H 0.434 Neutral MSH2 P43246 N412I 412 N I 0.35 Neutral MSH2 P43246 N412K 412 N K 0.116 Neutral MSH2 P43246 N412L 412 N L 0.182 Neutral MSH2 P43246 N412M 412 N M 0.824 Pathogenic MSH2 P43246 N412P 412 N P 0.752 Pathogenic MSH2 P43246 N412Q 412 N Q 0.056 Neutral MSH2 P43246 N412R 412 N R 0.562 Pathogenic MSH2 P43246 N412S 412 N S 0.048 Neutral MSH2 P43246 N412T 412 N T 0.082 Neutral MSH2 P43246 N412V 412 N V 0.174 Neutral MSH2 P43246 N412W 412 N W 0.954 Pathogenic MSH2 P43246 N412Y 412 N Y 0.946 Pathogenic MSH2 P43246 Q413A 413 Q A 0.132 Neutral MSH2 P43246 Q413C 413 Q C 0.302 Neutral MSH2 P43246 Q413D 413 Q D 0.548 Pathogenic MSH2 P43246 Q413E 413 Q E 0.582 Pathogenic MSH2 P43246 Q413F 413 Q F 0.838 Pathogenic MSH2 P43246 Q413G 413 Q G 0.386 Neutral MSH2 P43246 Q413H 413 Q H 0.07 Neutral MSH2 P43246 Q413I 413 Q I 0.428 Neutral MSH2 P43246 Q413K 413 Q K 0.042 Neutral MSH2 P43246 Q413L 413 Q L 0.206 Neutral MSH2 P43246 Q413M 413 Q M 0.738 Pathogenic MSH2 P43246 Q413N 413 Q N 0.09 Neutral MSH2 P43246 Q413P 413 Q P 0.796 Pathogenic MSH2 P43246 Q413R 413 Q R 0.128 Neutral MSH2 P43246 Q413S 413 Q S 0.294 Neutral MSH2 P43246 Q413T 413 Q T 0.446 Neutral MSH2 P43246 Q413V 413 Q V 0.708 Pathogenic MSH2 P43246 Q413W 413 Q W 0.924 Pathogenic MSH2 P43246 Q413Y 413 Q Y 0.496 Neutral MSH2 P43246 L414A 414 L A 0.638 Pathogenic MSH2 P43246 L414C 414 L C 0.762 Pathogenic MSH2 P43246 L414D 414 L D 0.886 Pathogenic MSH2 P43246 L414E 414 L E 0.866 Pathogenic MSH2 P43246 L414F 414 L F 0.98 Pathogenic MSH2 P43246 L414G 414 L G 0.8 Pathogenic MSH2 P43246 L414H 414 L H 0.876 Pathogenic MSH2 P43246 L414I 414 L I 0.19 Neutral MSH2 P43246 L414K 414 L K 0.754 Pathogenic MSH2 P43246 L414M 414 L M 0.194 Neutral MSH2 P43246 L414N 414 L N 0.75 Pathogenic MSH2 P43246 L414P 414 L P 0.992 Pathogenic MSH2 P43246 L414Q 414 L Q 0.688 Pathogenic MSH2 P43246 L414R 414 L R 0.984 Pathogenic MSH2 P43246 L414S 414 L S 0.634 Pathogenic MSH2 P43246 L414T 414 L T 0.118 Neutral MSH2 P43246 L414V 414 L V 0.08 Neutral MSH2 P43246 L414W 414 L W 0.942 Pathogenic MSH2 P43246 L414Y 414 L Y 0.832 Pathogenic MSH2 P43246 P415A 415 P A 0.28 Neutral MSH2 P43246 P415C 415 P C 0.894 Pathogenic MSH2 P43246 P415D 415 P D 0.854 Pathogenic MSH2 P43246 P415E 415 P E 0.29 Neutral MSH2 P43246 P415F 415 P F 0.99 Pathogenic MSH2 P43246 P415G 415 P G 0.332 Neutral MSH2 P43246 P415H 415 P H 0.968 Pathogenic MSH2 P43246 P415I 415 P I 0.91 Pathogenic MSH2 P43246 P415K 415 P K 0.376 Neutral MSH2 P43246 P415L 415 P L 0.972 Pathogenic MSH2 P43246 P415M 415 P M 0.948 Pathogenic MSH2 P43246 P415N 415 P N 0.3 Neutral MSH2 P43246 P415Q 415 P Q 0.866 Pathogenic MSH2 P43246 P415R 415 P R 0.978 Pathogenic MSH2 P43246 P415S 415 P S 0.074 Neutral MSH2 P43246 P415T 415 P T 0.384 Neutral MSH2 P43246 P415V 415 P V 0.282 Neutral MSH2 P43246 P415W 415 P W 0.922 Pathogenic MSH2 P43246 P415Y 415 P Y 0.916 Pathogenic MSH2 P43246 N416A 416 N A 0.06 Neutral MSH2 P43246 N416C 416 N C 0.594 Pathogenic MSH2 P43246 N416D 416 N D 0.03 Neutral MSH2 P43246 N416E 416 N E 0.038 Neutral MSH2 P43246 N416F 416 N F 0.38 Neutral MSH2 P43246 N416G 416 N G 0.102 Neutral MSH2 P43246 N416H 416 N H 0.066 Neutral MSH2 P43246 N416I 416 N I 0.404 Neutral MSH2 P43246 N416K 416 N K 0.068 Neutral MSH2 P43246 N416L 416 N L 0.18 Neutral MSH2 P43246 N416M 416 N M 0.768 Pathogenic MSH2 P43246 N416P 416 N P 0.288 Neutral MSH2 P43246 N416Q 416 N Q 0.608 Pathogenic MSH2 P43246 N416R 416 N R 0.384 Neutral MSH2 P43246 N416S 416 N S 0.028 Neutral MSH2 P43246 N416T 416 N T 0.052 Neutral MSH2 P43246 N416V 416 N V 0.106 Neutral MSH2 P43246 N416W 416 N W 0.914 Pathogenic MSH2 P43246 N416Y 416 N Y 0.654 Pathogenic MSH2 P43246 V417A 417 V A 0.144 Neutral MSH2 P43246 V417C 417 V C 0.412 Neutral MSH2 P43246 V417D 417 V D 0.6 Pathogenic MSH2 P43246 V417E 417 V E 0.702 Pathogenic MSH2 P43246 V417F 417 V F 0.478 Neutral MSH2 P43246 V417G 417 V G 0.614 Pathogenic MSH2 P43246 V417H 417 V H 0.56 Pathogenic MSH2 P43246 V417I 417 V I 0.088 Neutral MSH2 P43246 V417K 417 V K 0.768 Pathogenic MSH2 P43246 V417L 417 V L 0.07 Neutral MSH2 P43246 V417M 417 V M 0.084 Neutral MSH2 P43246 V417N 417 V N 0.644 Pathogenic MSH2 P43246 V417P 417 V P 0.822 Pathogenic MSH2 P43246 V417Q 417 V Q 0.722 Pathogenic MSH2 P43246 V417R 417 V R 0.824 Pathogenic MSH2 P43246 V417S 417 V S 0.26 Neutral MSH2 P43246 V417T 417 V T 0.432 Neutral MSH2 P43246 V417W 417 V W 0.84 Pathogenic MSH2 P43246 V417Y 417 V Y 0.832 Pathogenic MSH2 P43246 I418A 418 I A 0.054 Neutral MSH2 P43246 I418C 418 I C 0.066 Neutral MSH2 P43246 I418D 418 I D 0.612 Pathogenic MSH2 P43246 I418E 418 I E 0.212 Neutral MSH2 P43246 I418F 418 I F 0.322 Neutral MSH2 P43246 I418G 418 I G 0.588 Pathogenic MSH2 P43246 I418H 418 I H 0.13 Neutral MSH2 P43246 I418K 418 I K 0.082 Neutral MSH2 P43246 I418L 418 I L 0.012 Neutral MSH2 P43246 I418M 418 I M 0.384 Neutral MSH2 P43246 I418N 418 I N 0.312 Neutral MSH2 P43246 I418P 418 I P 0.756 Pathogenic MSH2 P43246 I418Q 418 I Q 0.552 Pathogenic MSH2 P43246 I418R 418 I R 0.544 Pathogenic MSH2 P43246 I418S 418 I S 0.464 Neutral MSH2 P43246 I418T 418 I T 0.03 Neutral MSH2 P43246 I418V 418 I V 0.004 Neutral MSH2 P43246 I418W 418 I W 0.904 Pathogenic MSH2 P43246 I418Y 418 I Y 0.902 Pathogenic MSH2 P43246 Q419A 419 Q A 0.104 Neutral MSH2 P43246 Q419C 419 Q C 0.106 Neutral MSH2 P43246 Q419D 419 Q D 0.03 Neutral MSH2 P43246 Q419E 419 Q E 0.03 Neutral MSH2 P43246 Q419F 419 Q F 0.756 Pathogenic MSH2 P43246 Q419G 419 Q G 0.092 Neutral MSH2 P43246 Q419H 419 Q H 0.79 Pathogenic MSH2 P43246 Q419I 419 Q I 0.8 Pathogenic MSH2 P43246 Q419K 419 Q K 0.044 Neutral 2 MSH2 P43246 Q419L 419 Q L 0.466 Neutral MSH2 P43246 Q419M 419 Q M 0.17 Neutral MSH2 P43246 Q419N 419 Q N 0.058 Neutral MSH2 P43246 Q419P 419 Q P 0.814 Pathogenic MSH2 P43246 Q419R 419 Q R 0.052 Neutral MSH2 P43246 Q419S 419 Q S 0.076 Neutral MSH2 P43246 Q419T 419 Q T 0.018 Neutral MSH2 P43246 Q419V 419 Q V 0.79 Pathogenic MSH2 P43246 Q419W 419 Q W 0.9 Pathogenic MSH2 P43246 Q419Y 419 Q Y 0.836 Pathogenic MSH2 P43246 F42A 42 F A 0.406 Neutral MSH2 P43246 F42C 42 F C 0.126 Neutral MSH2 P43246 F42D 42 F D 0.496 Neutral MSH2 P43246 F42E 42 F E 0.92 Pathogenic MSH2 P43246 F42G 42 F G 0.5 Pathogenic MSH2 P43246 F42H 42 F H 0.596 Pathogenic MSH2 P43246 F42I 42 F I 0.226 Neutral MSH2 P43246 F42K 42 F K 0.88 Pathogenic MSH2 P43246 F42L 42 F L 0.49 Neutral MSH2 P43246 F42M 42 F M 0.61 Pathogenic MSH2 P43246 F42N 42 F N 0.75 Pathogenic MSH2 P43246 F42P 42 F P 0.866 Pathogenic MSH2 P43246 F42Q 42 F Q 0.788 Pathogenic MSH2 P43246 F42R 42 F R 0.272 Neutral MSH2 P43246 F42S 42 F S 0.416 Neutral MSH2 P43246 F42T 42 F T 0.528 Pathogenic MSH2 P43246 F42V 42 F V 0.684 Pathogenic MSH2 P43246 F42W 42 F W 0.628 Pathogenic MSH2 P43246 F42Y 42 F Y 0.392 Neutral MSH2 P43246 A420C 420 A C 0.21 Neutral MSH2 P43246 A420D 420 A D 0.784 Pathogenic MSH2 P43246 A420E 420 A E 0.884 Pathogenic MSH2 P43246 A420F 420 A F 0.968 Pathogenic MSH2 P43246 A420G 420 A G 0.46 Neutral MSH2 P43246 A420H 420 A H 0.706 Pathogenic MSH2 P43246 A420I 420 A I 0.632 Pathogenic MSH2 P43246 A420K 420 A K 0.612 Pathogenic MSH2 P43246 A420L 420 A L 0.582 Pathogenic MSH2 P43246 A420M 420 A M 0.702 Pathogenic MSH2 P43246 A420N 420 A N 0.574 Pathogenic MSH2 P43246 A420P 420 A P 0.884 Pathogenic MSH2 P43246 A420Q 420 A Q 0.51 Pathogenic MSH2 P43246 A420R 420 A R 0.926 Pathogenic MSH2 P43246 A420S 420 A S 0.01 Neutral MSH2 P43246 A420T 420 A T 0.056 Neutral MSH2 P43246 A420V 420 A V 0.126 Neutral MSH2 P43246 A420W 420 A W 0.954 Pathogenic MSH2 P43246 A420Y 420 A Y 0.94 Pathogenic MSH2 P43246 L421A 421 L A 0.694 Pathogenic MSH2 P43246 L421C 421 L C 0.8 Pathogenic MSH2 P43246 L421D 421 L D 0.864 Pathogenic MSH2 P43246 L421E 421 L E 0.508 Pathogenic MSH2 P43246 L421F 421 L F 0.422 Neutral MSH2 P43246 L421G 421 L G 0.832 Pathogenic MSH2 P43246 L421H 421 L H 0.892 Pathogenic MSH2 P43246 L421I 421 L I 0.258 Neutral MSH2 P43246 L421K 421 L K 0.664 Pathogenic MSH2 P43246 L421M 421 L M 0.15 Neutral MSH2 P43246 L421N 421 L N 0.766 Pathogenic MSH2 P43246 L421P 421 L P 0.96 Pathogenic MSH2 P43246 L421Q 421 L Q 0.734 Pathogenic MSH2 P43246 L421R 421 L R 0.964 Pathogenic MSH2 P43246 L421S 421 L S 0.64 Pathogenic MSH2 P43246 L421T 421 L T 0.566 Pathogenic MSH2 P43246 L421V 421 L V 0.11 Neutral MSH2 P43246 L421W 421 L W 0.838 Pathogenic MSH2 P43246 L421Y 421 L Y 0.862 Pathogenic MSH2 P43246 E422A 422 E A 0.264 Neutral MSH2 P43246 E422C 422 E C 0.536 Pathogenic MSH2 P43246 E422D 422 E D 0.1 Neutral MSH2 P43246 E422F 422 E F 0.86 Pathogenic MSH2 P43246 E422G 422 E G 0.1 Neutral MSH2 P43246 E422H 422 E H 0.592 Pathogenic MSH2 P43246 E422I 422 E I 0.808 Pathogenic MSH2 P43246 E422K 422 E K 0.274 Neutral MSH2 P43246 E422L 422 E L 0.296 Neutral MSH2 P43246 E422M 422 E M 0.718 Pathogenic MSH2 P43246 E422N 422 E N 0.076 Neutral MSH2 P43246 E422P 422 E P 0.866 Pathogenic MSH2 P43246 E422Q 422 E Q 0.074 Neutral MSH2 P43246 E422R 422 E R 0.242 Neutral MSH2 P43246 E422S 422 E S 0.146 Neutral MSH2 P43246 E422T 422 E T 0.18 Neutral MSH2 P43246 E422V 422 E V 0.472 Neutral MSH2 P43246 E422W 422 E W 0.932 Pathogenic MSH2 P43246 E422Y 422 E Y 0.894 Pathogenic MSH2 P43246 K423A 423 K A 0.078 Neutral MSH2 P43246 K423C 423 K C 0.188 Neutral MSH2 P43246 K423D 423 K D 0.03 Neutral MSH2 P43246 K423E 423 K E 0.032 Neutral MSH2 P43246 K423F 423 K F 0.702 Pathogenic MSH2 P43246 K423G 423 K G 0.094 Neutral MSH2 P43246 K423H 423 K H 0.21 Neutral MSH2 P43246 K423I 423 K I 0.71 Pathogenic MSH2 P43246 K423L 423 K L 0.376 Neutral MSH2 P43246 K423M 423 K M 0.498 Neutral MSH2 P43246 K423N 423 K N 0.04 Neutral MSH2 P43246 K423P 423 K P 0.356 Neutral MSH2 P43246 K423Q 423 K Q 0.042 Neutral MSH2 P43246 K423R 423 K R 0.034 Neutral MSH2 P43246 K423S 423 K S 0.064 Neutral MSH2 P43246 K423T 423 K T 0.074 Neutral MSH2 P43246 K423V 423 K V 0.684 Pathogenic MSH2 P43246 K423W 423 K W 0.884 Pathogenic MSH2 P43246 K423Y 423 K Y 0.826 Pathogenic MSH2 P43246 H424A 424 H A 0.076 Neutral MSH2 P43246 H424C 424 H C 0.042 Neutral MSH2 P43246 H424D 424 H D 0.028 Neutral MSH2 P43246 H424E 424 H E 0.058 Neutral MSH2 P43246 H424F 424 H F 0.204 Neutral MSH2 P43246 H424G 424 H G 0.11 Neutral MSH2 P43246 H424I 424 H I 0.258 Neutral MSH2 P43246 H424K 424 H K 0.004 Neutral MSH2 P43246 H424L 424 H L 0.23 Neutral MSH2 P43246 H424M 424 H M 0.108 Neutral MSH2 P43246 H424N 424 H N 0.058 Neutral MSH2 P43246 H424P 424 H P 0.274 Neutral MSH2 P43246 H424Q 424 H Q 0.094 Neutral MSH2 P43246 H424R 424 H R 0.046 Neutral MSH2 P43246 H424S 424 H S 0.218 Neutral MSH2 P43246 H424T 424 H T 0.16 Neutral MSH2 P43246 H424V 424 H V 0.144 Neutral MSH2 P43246 H424W 424 H W 0.398 Neutral MSH2 P43246 H424Y 424 H Y 0.03 Neutral MSH2 P43246 E425A 425 E A 0.122 Neutral MSH2 P43246 E425C 425 E C 0.064 Neutral MSH2 P43246 E425D 425 E D 0.082 Neutral MSH2 P43246 E425F 425 E F 0.272 Neutral MSH2 P43246 E425G 425 E G 0.084 Neutral MSH2 P43246 E425H 425 E H 0.104 Neutral MSH2 P43246 E425I 425 E I 0.284 Neutral MSH2 P43246 E425K 425 E K 0.144 Neutral MSH2 P43246 E425L 425 E L 0.286 Neutral MSH2 P43246 E425M 425 E M 0.164 Neutral MSH2 P43246 E425N 425 E N 0.056 Neutral MSH2 P43246 E425P 425 E P 0.3 Neutral MSH2 P43246 E425Q 425 E Q 0.056 Neutral MSH2 P43246 E425R 425 E R 0.036 Neutral MSH2 P43246 E425S 425 E S 0.156 Neutral MSH2 P43246 E425T 425 E T 0.14 Neutral MSH2 P43246 E425V 425 E V 0.25 Neutral MSH2 P43246 E425W 425 E W 0.43 Neutral MSH2 P43246 E425Y 425 E Y 0.222 Neutral MSH2 P43246 G426A 426 G A 0.058 Neutral MSH2 P43246 G426C 426 G C 0.132 Neutral MSH2 P43246 G426D 426 G D 0.244 Neutral MSH2 P43246 G426E 426 G E 0.172 Neutral MSH2 P43246 G426F 426 G F 0.498 Neutral MSH2 P43246 G426H 426 G H 0.442 Neutral MSH2 P43246 G426I 426 G I 0.428 Neutral MSH2 P43246 G426K 426 G K 0.27 Neutral MSH2 P43246 G426L 426 G L 0.316 Neutral MSH2 P43246 G426M 426 G M 0.422 Neutral MSH2 P43246 G426N 426 G N 0.252 Neutral MSH2 P43246 G426P 426 G P 0.392 Neutral MSH2 P43246 G426Q 426 G Q 0.18 Neutral MSH2 P43246 G426R 426 G R 0.468 Neutral MSH2 P43246 G426S 426 G S 0.186 Neutral MSH2 P43246 G426T 426 G T 0.272 Neutral MSH2 P43246 G426V 426 G V 0.394 Neutral MSH2 P43246 G426W 426 G W 0.498 Neutral MSH2 P43246 G426Y 426 G Y 0.5 Pathogenic MSH2 P43246 K427A 427 K A 0.062 Neutral MSH2 P43246 K427C 427 K C 0.048 Neutral MSH2 P43246 K427D 427 K D 0.09 Neutral MSH2 P43246 K427E 427 K E 0.006 Neutral MSH2 P43246 K427F 427 K F 0.284 Neutral MSH2 P43246 K427G 427 K G 0.044 Neutral MSH2 P43246 K427H 427 K H 0.072 Neutral MSH2 P43246 K427I 427 K I 0.154 Neutral MSH2 P43246 K427L 427 K L 0.296 Neutral MSH2 P43246 K427M 427 K M 0.172 Neutral MSH2 P43246 K427N 427 K N 0.06 Neutral MSH2 P43246 K427P 427 K P 0.304 Neutral MSH2 P43246 K427Q 427 K Q 0.058 Neutral MSH2 P43246 K427R 427 K R 0.094 Neutral MSH2 P43246 K427S 427 K S 0.234 Neutral MSH2 P43246 K427T 427 K T 0.194 Neutral MSH2 P43246 K427V 427 K V 0.23 Neutral MSH2 P43246 K427W 427 K W 0.582 Pathogenic MSH2 P43246 K427Y 427 K Y 0.48 Neutral MSH2 P43246 H428A 428 H A 0.042 Neutral MSH2 P43246 H428C 428 H C 0.042 Neutral MSH2 P43246 H428D 428 H D 0 Neutral MSH2 P43246 H428E 428 H E 0 Neutral MSH2 P43246 H428F 428 H F 0.204 Neutral MSH2 P43246 H428G 428 H G 0.11 Neutral MSH2 P43246 H428I 428 H I 0.274 Neutral MSH2 P43246 H428K 428 H K 0.004 Neutral MSH2 P43246 H428L 428 H L 0.232 Neutral MSH2 P43246 H428M 428 H M 0.108 Neutral MSH2 P43246 H428N 428 H N 0.002 Neutral MSH2 P43246 H428P 428 H P 0.08 Neutral MSH2 P43246 H428Q 428 H Q 0.006 Neutral MSH2 P43246 H428R 428 H R 0 Neutral MSH2 P43246 H428S 428 H S 0.012 Neutral MSH2 P43246 H428T 428 H T 0.008 Neutral MSH2 P43246 H428V 428 H V 0.064 Neutral MSH2 P43246 H428W 428 H W 0.398 Neutral MSH2 P43246 H428Y 428 H Y 0.252 Neutral MSH2 P43246 Q429A 429 Q A 0.098 Neutral MSH2 P43246 Q429C 429 Q C 0.312 Neutral MSH2 P43246 Q429D 429 Q D 0.24 Neutral MSH2 P43246 Q429E 429 Q E 0.296 Neutral MSH2 P43246 Q429F 429 Q F 0.288 Neutral MSH2 P43246 Q429G 429 Q G 0.466 Neutral MSH2 P43246 Q429H 429 Q H 0.064 Neutral MSH2 P43246 Q429I 429 Q I 0.304 Neutral MSH2 P43246 Q429K 429 Q K 0.054 Neutral MSH2 P43246 Q429L 429 Q L 0.166 Neutral MSH2 P43246 Q429M 429 Q M 0.63 Pathogenic MSH2 P43246 Q429N 429 Q N 0.064 Neutral MSH2 P43246 Q429P 429 Q P 0.77 Pathogenic MSH2 P43246 Q429R 429 Q R 0.08 Neutral MSH2 P43246 Q429S 429 Q S 0.162 Neutral MSH2 P43246 Q429T 429 Q T 0.48 Neutral MSH2 P43246 Q429V 429 Q V 0.078 Neutral MSH2 P43246 Q429W 429 Q W 0.732 Pathogenic MSH2 P43246 Q429Y 429 Q Y 0.448 Neutral MSH2 P43246 Y43A 43 Y A 0.428 Neutral MSH2 P43246 Y43C 43 Y C 0.664 Pathogenic MSH2 P43246 Y43D 43 Y D 0.816 Pathogenic MSH2 P43246 Y43E 43 Y E 0.718 Pathogenic MSH2 P43246 Y43F 43 Y F 0.176 Neutral MSH2 P43246 Y43G 43 Y G 0.476 Neutral MSH2 P43246 Y43H 43 Y H 0.272 Neutral MSH2 P43246 Y43I 43 Y I 0.352 Neutral MSH2 P43246 Y43K 43 Y K 0.82 Pathogenic MSH2 P43246 Y43L 43 Y L 0.202 Neutral MSH2 P43246 Y43M 43 Y M 0.678 Pathogenic MSH2 P43246 Y43N 43 Y N 0.712 Pathogenic MSH2 P43246 Y43P 43 Y P 0.798 Pathogenic MSH2 P43246 Y43Q 43 Y Q 0.62 Pathogenic MSH2 P43246 Y43R 43 Y R 0.734 Pathogenic MSH2 P43246 Y43S 43 Y S 0.476 Neutral MSH2 P43246 Y43T 43 Y T 0.66 Pathogenic MSH2 P43246 Y43V 43 Y V 0.714 Pathogenic MSH2 P43246 Y43W 43 Y W 0.49 Neutral MSH2 P43246 K430A 430 K A 0.064 Neutral MSH2 P43246 K430C 430 K C 0.058 Neutral MSH2 P43246 K430D 430 K D 0.222 Neutral MSH2 P43246 K430E 430 K E 0.018 Neutral MSH2 P43246 K430F 430 K F 0.75 Pathogenic MSH2 P43246 K430G 430 K G 0.096 Neutral MSH2 P43246 K430H 430 K H 0.274 Neutral MSH2 P43246 K430I 430 K I 0.8 Pathogenic MSH2 P43246 K430L 430 K L 0.426 Neutral MSH2 P43246 K430M 430 K M 0.604 Pathogenic MSH2 P43246 K430N 430 K N 0.026 Neutral MSH2 P43246 K430P 430 K P 0.78 Pathogenic MSH2 P43246 K430Q 430 K Q 0.024 Neutral MSH2 P43246 K430R 430 K R 0.014 Neutral MSH2 P43246 K430S 430 K S 0.026 Neutral MSH2 P43246 K430T 430 K T 0.082 Neutral MSH2 P43246 K430V 430 K V 0.72 Pathogenic MSH2 P43246 K430W 430 K W 0.932 Pathogenic MSH2 P43246 K430Y 430 K Y 0.284 Neutral MSH2 P43246 L431A 431 L A 0.122 Neutral MSH2 P43246 L431C 431 L C 0.64 Pathogenic MSH2 P43246 L431D 431 L D 0.566 Pathogenic MSH2 P43246 L431E 431 L E 0.518 Pathogenic MSH2 P43246 L431F 431 L F 0.598 Pathogenic MSH2 P43246 L431G 431 L G 0.504 Pathogenic MSH2 P43246 L431H 431 L H 0.71 Pathogenic MSH2 P43246 L431I 431 L I 0.262 Neutral MSH2 P43246 L431K 431 L K 0.192 Neutral MSH2 P43246 L431M 431 L M 0.17 Neutral MSH2 P43246 L431N 431 L N 0.516 Pathogenic MSH2 P43246 L431P 431 L P 0.284 Neutral MSH2 P43246 L431Q 431 L Q 0.282 Neutral MSH2 P43246 L431R 431 L R 0.728 Pathogenic MSH2 P43246 L431S 431 L S 0.21 Neutral MSH2 P43246 L431T 431 L T 0.128 Neutral MSH2 P43246 L431V 431 L V 0.328 Neutral MSH2 P43246 L431W 431 L W 0.816 Pathogenic MSH2 P43246 L431Y 431 L Y 0.794 Pathogenic MSH2 P43246 L432A 432 L A 0.562 Pathogenic MSH2 P43246 L432C 432 L C 0.686 Pathogenic MSH2 P43246 L432D 432 L D 0.912 Pathogenic MSH2 P43246 L432E 432 L E 0.89 Pathogenic MSH2 P43246 L432F 432 L F 0.628 Pathogenic MSH2 P43246 L432G 432 L G 0.81 Pathogenic MSH2 P43246 L432H 432 L H 0.784 Pathogenic MSH2 P43246 L432I 432 L I 0.14 Neutral MSH2 P43246 L432K 432 L K 0.416 Neutral MSH2 P43246 L432M 432 L M 0.178 Neutral MSH2 P43246 L432N 432 L N 0.782 Pathogenic MSH2 P43246 L432P 432 L P 0.98 Pathogenic MSH2 P43246 L432Q 432 L Q 0.612 Pathogenic MSH2 P43246 L432R 432 L R 0.996 Pathogenic MSH2 P43246 L432S 432 L S 0.602 Pathogenic MSH2 P43246 L432T 432 L T 0.58 Pathogenic MSH2 P43246 L432V 432 L V 0.08 Neutral MSH2 P43246 L432W 432 L W 0.808 Pathogenic MSH2 P43246 L432Y 432 L Y 0.868 Pathogenic MSH2 P43246 L433A 433 L A 0.018 Neutral MSH2 P43246 L433C 433 L C 0.202 Neutral MSH2 P43246 L433D 433 L D 0.056 Neutral MSH2 P43246 L433E 433 L E 0.044 Neutral MSH2 P43246 L433F 433 L F 0.574 Pathogenic MSH2 P43246 L433G 433 L G 0.396 Neutral MSH2 P43246 L433H 433 L H 0.012 Neutral MSH2 P43246 L433I 433 L I 0.194 Neutral MSH2 P43246 L433K 433 L K 0.03 Neutral MSH2 P43246 L433M 433 L M 0.016 Neutral MSH2 P43246 L433N 433 L N 0.046 Neutral MSH2 P43246 L433P 433 L P 0.536 Pathogenic MSH2 P43246 L433Q 433 L Q 0.012 Neutral MSH2 P43246 L433R 433 L R 0.43 Neutral MSH2 P43246 L433S 433 L S 0.028 Neutral MSH2 P43246 L433T 433 L T 0.026 Neutral MSH2 P43246 L433V 433 L V 0.164 Neutral MSH2 P43246 L433W 433 L W 0.674 Pathogenic MSH2 P43246 L433Y 433 L Y 0.634 Pathogenic MSH2 P43246 A434C 434 A C 0.742 Pathogenic MSH2 P43246 A434D 434 A D 0.692 Pathogenic MSH2 P43246 A434E 434 A E 0.598 Pathogenic MSH2 P43246 A434F 434 A F 0.968 Pathogenic MSH2 P43246 A434G 434 A G 0.512 Pathogenic MSH2 P43246 A434H 434 A H 0.698 Pathogenic MSH2 P43246 A434I 434 A I 0.682 Pathogenic MSH2 P43246 A434K 434 A K 0.554 Pathogenic MSH2 P43246 A434L 434 A L 0.646 Pathogenic MSH2 P43246 A434M 434 A M 0.814 Pathogenic MSH2 P43246 A434N 434 A N 0.6 Pathogenic MSH2 P43246 A434P 434 A P 0.914 Pathogenic MSH2 P43246 A434Q 434 A Q 0.51 Pathogenic MSH2 P43246 A434R 434 A R 0.928 Pathogenic MSH2 P43246 A434S 434 A S 0.008 Neutral MSH2 P43246 A434T 434 A T 0.044 Neutral MSH2 P43246 A434V 434 A V 0.156 Neutral MSH2 P43246 A434W 434 A W 0.956 Pathogenic MSH2 P43246 A434Y 434 A Y 0.942 Pathogenic MSH2 P43246 V435A 435 V A 0.038 Neutral MSH2 P43246 V435C 435 V C 0.192 Neutral MSH2 P43246 V435D 435 V D 0.494 Neutral MSH2 P43246 V435E 435 V E 0.106 Neutral MSH2 P43246 V435F 435 V F 0.53 Pathogenic MSH2 P43246 V435G 435 V G 0.58 Pathogenic MSH2 P43246 V435H 435 V H 0.162 Neutral MSH2 P43246 V435I 435 V I 0.028 Neutral MSH2 P43246 V435K 435 V K 0.134 Neutral MSH2 P43246 V435L 435 V L 0.032 Neutral MSH2 P43246 V435M 435 V M 0.058 Neutral MSH2 P43246 V435N 435 V N 0.298 Neutral MSH2 P43246 V435P 435 V P 0.658 Pathogenic MSH2 P43246 V435Q 435 V Q 0.12 Neutral MSH2 P43246 V435R 435 V R 0.458 Neutral MSH2 P43246 V435S 435 V S 0.068 Neutral MSH2 P43246 V435T 435 V T 0.038 Neutral MSH2 P43246 V435W 435 V W 0.616 Pathogenic MSH2 P43246 V435Y 435 V Y 0.664 Pathogenic MSH2 P43246 F436A 436 F A 0.416 Neutral MSH2 P43246 F436C 436 F C 0.58 Pathogenic MSH2 P43246 F436D 436 F D 0.79 Pathogenic MSH2 P43246 F436E 436 F E 0.87 Pathogenic MSH2 P43246 F436G 436 F G 0.3 Neutral MSH2 P43246 F436H 436 F H 0.638 Pathogenic MSH2 P43246 F436I 436 F I 0.118 Neutral MSH2 P43246 F436K 436 F K 0.852 Pathogenic MSH2 P43246 F436L 436 F L 0.088 Neutral MSH2 P43246 F436M 436 F M 0.66 Pathogenic MSH2 P43246 F436N 436 F N 0.71 Pathogenic MSH2 P43246 F436P 436 F P 0.942 Pathogenic MSH2 P43246 F436Q 436 F Q 0.45 Neutral MSH2 P43246 F436R 436 F R 0.92 Pathogenic MSH2 P43246 F436S 436 F S 0.758 Pathogenic MSH2 P43246 F436T 436 F T 0.584 Pathogenic MSH2 P43246 F436V 436 F V 0.418 Neutral MSH2 P43246 F436W 436 F W 0.644 Pathogenic MSH2 P43246 F436Y 436 F Y 0.362 Neutral MSH2 P43246 V437A 437 V A 0.022 Neutral MSH2 P43246 V437C 437 V C 0.036 Neutral MSH2 P43246 V437D 437 V D 0.548 Pathogenic MSH2 P43246 V437E 437 V E 0.544 Pathogenic MSH2 P43246 V437F 437 V F 0.626 Pathogenic MSH2 P43246 V437G 437 V G 0.51 Pathogenic MSH2 P43246 V437H 437 V H 0.506 Pathogenic MSH2 P43246 V437I 437 V I 0.06 Neutral MSH2 P43246 V437K 437 V K 0.742 Pathogenic MSH2 P43246 V437L 437 V L 0.062 Neutral MSH2 P43246 V437M 437 V M 0.45 Neutral MSH2 P43246 V437N 437 V N 0.52 Pathogenic MSH2 P43246 V437P 437 V P 0.812 Pathogenic MSH2 P43246 V437Q 437 V Q 0.68 Pathogenic MSH2 P43246 V437R 437 V R 0.606 Pathogenic MSH2 P43246 V437S 437 V S 0.044 Neutral MSH2 P43246 V437T 437 V T 0.022 Neutral MSH2 P43246 V437W 437 V W 0.692 Pathogenic MSH2 P43246 V437Y 437 V Y 0.486 Neutral MSH2 P43246 T438A 438 T A 0.018 Neutral MSH2 P43246 T438C 438 T C 0.372 Neutral MSH2 P43246 T438D 438 T D 0.07 Neutral MSH2 P43246 T438E 438 T E 0.092 Neutral MSH2 P43246 T438F 438 T F 0.636 Pathogenic MSH2 P43246 T438G 438 T G 0.234 Neutral MSH2 P43246 T438H 438 T H 0.188 Neutral MSH2 P43246 T438I 438 T I 0.088 Neutral MSH2 P43246 T438K 438 T K 0.046 Neutral MSH2 P43246 T438L 438 T L 0.118 Neutral MSH2 P43246 T438M 438 T M 0.326 Neutral MSH2 P43246 T438N 438 T N 0.018 Neutral MSH2 P43246 T438P 438 T P 0.478 Neutral MSH2 P43246 T438Q 438 T Q 0.024 Neutral MSH2 P43246 T438R 438 T R 0.382 Neutral MSH2 P43246 T438S 438 T S 0.02 Neutral MSH2 P43246 T438V 438 T V 0.052 Neutral MSH2 P43246 T438W 438 T W 0.886 Pathogenic MSH2 P43246 T438Y 438 T Y 0.874 Pathogenic MSH2 P43246 P439A 439 P A 0.16 Neutral MSH2 P43246 P439C 439 P C 0.928 Pathogenic MSH2 P43246 P439D 439 P D 0.194 Neutral MSH2 P43246 P439E 439 P E 0.276 Neutral MSH2 P43246 P439F 439 P F 0.812 Pathogenic MSH2 P43246 P439G 439 P G 0.206 Neutral MSH2 P43246 P439H 439 P H 0.532 Pathogenic MSH2 P43246 P439I 439 P I 0.918 Pathogenic MSH2 P43246 P439K 439 P K 0.258 Neutral MSH2 P43246 P439L 439 P L 0.976 Pathogenic MSH2 P43246 P439M 439 P M 0.972 Pathogenic MSH2 P43246 P439N 439 P N 0.154 Neutral MSH2 P43246 P439Q 439 P Q 0.568 Pathogenic MSH2 P43246 P439R 439 P R 0.7 Pathogenic MSH2 P43246 P439S 439 P S 0.1 Neutral MSH2 P43246 P439T 439 P T 0.202 Neutral MSH2 P43246 P439V 439 P V 0.836 Pathogenic MSH2 P43246 P439W 439 P W 0.928 Pathogenic MSH2 P43246 P439Y 439 P Y 0.922 Pathogenic MSH2 P43246 T44A 44 T A 0.172 Neutral MSH2 P43246 T44C 44 T C 0.3 Neutral MSH2 P43246 T44D 44 T D 0.848 Pathogenic MSH2 P43246 T44E 44 T E 0.912 Pathogenic MSH2 P43246 T44F 44 T F 0.716 Pathogenic MSH2 P43246 T44G 44 T G 0.588 Pathogenic MSH2 P43246 T44H 44 T H 0.86 Pathogenic MSH2 P43246 T44I 44 T I 0.6 Pathogenic MSH2 P43246 T44K 44 T K 0.874 Pathogenic MSH2 P43246 T44L 44 T L 0.588 Pathogenic MSH2 P43246 T44M 44 T M 0.966 Pathogenic MSH2 P43246 T44N 44 T N 0.77 Pathogenic MSH2 P43246 T44P 44 T P 0.916 Pathogenic MSH2 P43246 T44Q 44 T Q 0.78 Pathogenic MSH2 P43246 T44R 44 T R 0.968 Pathogenic MSH2 P43246 T44S 44 T S 0.048 Neutral MSH2 P43246 T44V 44 T V 0.89 Pathogenic MSH2 P43246 T44W 44 T W 0.994 Pathogenic MSH2 P43246 T44Y 44 T Y 0.994 Pathogenic MSH2 P43246 L440A 440 L A 0.082 Neutral MSH2 P43246 L440C 440 L C 0.134 Neutral MSH2 P43246 L440D 440 L D 0.25 Neutral MSH2 P43246 L440E 440 L E 0.232 Neutral MSH2 P43246 L440F 440 L F 0.16 Neutral MSH2 P43246 L440G 440 L G 0.264 Neutral MSH2 P43246 L440H 440 L H 0.126 Neutral MSH2 P43246 L440I 440 L I 0.064 Neutral MSH2 P43246 L440K 440 L K 0.178 Neutral MSH2 P43246 L440M 440 L M 0.188 Neutral MSH2 P43246 L440N 440 L N 0.242 Neutral MSH2 P43246 L440P 440 L P 0.338 Neutral 5 MSH2 P43246 L440Q 440 L Q 0.102 Neutral MSH2 P43246 L440R 440 L R 0.504 Pathogenic MSH2 P43246 L440S 440 L S 0.196 Neutral MSH2 P43246 L440T 440 L T 0.174 Neutral MSH2 P43246 L440V 440 L V 0.236 Neutral MSH2 P43246 L440W 440 L W 0.53 Pathogenic MSH2 P43246 L440Y 440 L Y 0.502 Pathogenic MSH2 P43246 T441A 441 T A 0.06 Neutral MSH2 P43246 T441C 441 T C 0.034 Neutral MSH2 P43246 T441D 441 T D 0.058 Neutral MSH2 P43246 T441E 441 T E 0.04 Neutral MSH2 P43246 T441F 441 T F 0.214 Neutral MSH2 P43246 T441G 441 T G 0.058 Neutral MSH2 P43246 T441H 441 T H 0.056 Neutral MSH2 P43246 T441I 441 T I 0.042 Neutral MSH2 P43246 T441K 441 T K 0.002 Neutral MSH2 P43246 T441L 441 T L 0.074 Neutral MSH2 P43246 T441M 441 T M 0.044 Neutral MSH2 P43246 T441N 441 T N 0 Neutral MSH2 P43246 T441P 441 T P 0.1 Neutral MSH2 P43246 T441Q 441 T Q 0.052 Neutral MSH2 P43246 T441R 441 T R 0.156 Neutral MSH2 P43246 T441S 441 T S 0 Neutral MSH2 P43246 T441V 441 T V 0.016 Neutral MSH2 P43246 T441W 441 T W 0.466 Neutral MSH2 P43246 T441Y 441 T Y 0.424 Neutral MSH2 P43246 D442A 442 D A 0.146 Neutral MSH2 P43246 D442C 442 D C 0.262 Neutral MSH2 P43246 D442E 442 D E 0.016 Neutral MSH2 P43246 D442F 442 D F 0.626 Pathogenic MSH2 P43246 D442G 442 D G 0.2 Neutral MSH2 P43246 D442H 442 D H 0.16 Neutral MSH2 P43246 D442I 442 D I 0.438 Neutral MSH2 P43246 D442K 442 D K 0.308 Neutral MSH2 P43246 D442L 442 D L 0.43 Neutral MSH2 P43246 D442M 442 D M 0.338 Neutral MSH2 P43246 D442N 442 D N 0.094 Neutral MSH2 P43246 D442P 442 D P 0.466 Neutral MSH2 P43246 D442Q 442 D Q 0.18 Neutral MSH2 P43246 D442R 442 D R 0.29 Neutral MSH2 P43246 D442S 442 D S 0.264 Neutral MSH2 P43246 D442T 442 D T 0.196 Neutral MSH2 P43246 D442V 442 D V 0.43 Neutral MSH2 P43246 D442W 442 D W 0.712 Pathogenic MSH2 P43246 D442Y 442 D Y 0.684 Pathogenic MSH2 P43246 L443A 443 L A 0.076 Neutral MSH2 P43246 L443C 443 L C 0.08 Neutral MSH2 P43246 L443D 443 L D 0.124 Neutral MSH2 P43246 L443E 443 L E 0.236 Neutral MSH2 P43246 L443F 443 L F 0.42 Neutral MSH2 P43246 L443G 443 L G 0.268 Neutral MSH2 P43246 L443H 443 L H 0.13 Neutral MSH2 P43246 L443I 443 L I 0.004 Neutral MSH2 P43246 L443K 443 L K 0.186 Neutral MSH2 P43246 L443M 443 L M 0.098 Neutral MSH2 P43246 L443N 443 L N 0.246 Neutral MSH2 P43246 L443P 443 L P 0.348 Neutral MSH2 P43246 L443Q 443 L Q 0.108 Neutral MSH2 P43246 L443R 443 L R 0.508 Pathogenic MSH2 P43246 L443S 443 L S 0.202 Neutral MSH2 P43246 L443T 443 L T 0.182 Neutral MSH2 P43246 L443V 443 L V 0.244 Neutral MSH2 P43246 L443W 443 L W 0.54 Pathogenic MSH2 P43246 L443Y 443 L Y 0.502 Pathogenic MSH2 P43246 R444A 444 R A 0.036 Neutral MSH2 P43246 R444C 444 R C 0.074 Neutral MSH2 P43246 R444D 444 R D 0.018 Neutral MSH2 P43246 R444E 444 R E 0.022 Neutral MSH2 P43246 R444F 444 R F 0.27 Neutral MSH2 P43246 R444G 444 R G 0.1 Neutral MSH2 P43246 R444H 444 R H 0.004 Neutral MSH2 P43246 R444I 444 R I 0.09 Neutral MSH2 P43246 R444K 444 R K 0.168 Neutral MSH2 P43246 R444L 444 R L 0.014 Neutral MSH2 P43246 R444M 444 R M 0.164 Neutral MSH2 P43246 R444N 444 R N 0.008 Neutral MSH2 P43246 R444P 444 R P 0.106 Neutral MSH2 P43246 R444Q 444 R Q 0.01 Neutral MSH2 P43246 R444S 444 R S 0.02 Neutral MSH2 P43246 R444T 444 R T 0.026 Neutral MSH2 P43246 R444V 444 R V 0.03 Neutral MSH2 P43246 R444W 444 R W 0.384 Neutral MSH2 P43246 R444Y 444 R Y 0.182 Neutral MSH2 P43246 S445A 445 S A 0.032 Neutral MSH2 P43246 S445C 445 S C 0.226 Neutral MSH2 P43246 S445D 445 S D 0.052 Neutral MSH2 P43246 S445E 445 S E 0.366 Neutral MSH2 P43246 S445F 445 S F 0.756 Pathogenic MSH2 P43246 S445G 445 S G 0.032 Neutral MSH2 P43246 S445H 445 S H 0.61 Pathogenic MSH2 P43246 S445I 445 S I 0.412 Neutral MSH2 P43246 S445K 445 S K 0.382 Neutral MSH2 P43246 S445L 445 S L 0.114 Neutral MSH2 P43246 S445M 445 S M 0.53 Pathogenic MSH2 P43246 S445N 445 S N 0.04 Neutral MSH2 P43246 S445P 445 S P 0.438 Neutral MSH2 P43246 S445Q 445 S Q 0.394 Neutral MSH2 P43246 S445R 445 S R 0.686 Pathogenic MSH2 P43246 S445T 445 S T 0.048 Neutral MSH2 P43246 S445V 445 S V 0.2 Neutral MSH2 P43246 S445W 445 S W 0.904 Pathogenic MSH2 P43246 S445Y 445 S Y 0.886 Pathogenic MSH2 P43246 D446A 446 D A 0.126 Neutral MSH2 P43246 D446C 446 D C 0.754 Pathogenic MSH2 P43246 D446E 446 D E 0.088 Neutral MSH2 P43246 D446F 446 D F 0.344 Neutral MSH2 P43246 D446G 446 D G 0.5 Pathogenic MSH2 P43246 D446H 446 D H 0.096 Neutral MSH2 P43246 D446I 446 D I 0.828 Pathogenic MSH2 P43246 D446K 446 D K 0.204 Neutral MSH2 P43246 D446L 446 D L 0.418 Neutral MSH2 P43246 D446M 446 D M 0.822 Pathogenic MSH2 P43246 D446N 446 D N 0.034 Neutral MSH2 P43246 D446P 446 D P 0.122 Neutral MSH2 P43246 D446Q 446 D Q 0.164 Neutral MSH2 P43246 D446R 446 D R 0.54 Pathogenic MSH2 P43246 D446S 446 D S 0.04 Neutral MSH2 P43246 D446T 446 D T 0.604 Pathogenic MSH2 P43246 D446V 446 D V 0.942 Pathogenic MSH2 P43246 D446W 446 D W 0.974 Pathogenic MSH2 P43246 D446Y 446 D Y 0.968 Pathogenic MSH2 P43246 F447A 447 F A 0.24 Neutral MSH2 P43246 F447C 447 F C 0.256 Neutral MSH2 P43246 F447D 447 F D 0.75 Pathogenic MSH2 P43246 F447E 447 F E 0.816 Pathogenic MSH2 P43246 F447G 447 F G 0.464 Neutral MSH2 P43246 F447H 447 F H 0.68 Pathogenic MSH2 P43246 F447I 447 F I 0.25 Neutral MSH2 P43246 F447K 447 F K 0.8 Pathogenic MSH2 P43246 F447L 447 F L 0.15 Neutral MSH2 P43246 F447M 447 F M 0.14 Neutral MSH2 P43246 F447N 447 F N 0.418 Neutral MSH2 P43246 F447P 447 F P 0.93 Pathogenic MSH2 P43246 F447Q 447 F Q 0.69 Pathogenic MSH2 P43246 F447R 447 F R 0.88 Pathogenic MSH2 P43246 F447S 447 F S 0.76 Pathogenic MSH2 P43246 F447T 447 F T 0.552 Pathogenic MSH2 P43246 F447V 447 F V 0.42 Neutral MSH2 P43246 F447W 447 F W 0.93 Pathogenic MSH2 P43246 F447Y 447 F Y 0.408 Neutral MSH2 P43246 S448A 448 S A 0.034 Neutral MSH2 P43246 S448C 448 S C 0.248 Neutral MSH2 P43246 S448D 448 S D 0.036 Neutral MSH2 P43246 S448E 448 S E 0.378 Neutral MSH2 P43246 S448F 448 S F 0.74 Pathogenic MSH2 P43246 S448G 448 S G 0.02 Neutral MSH2 P43246 S448H 448 S H 0.522 Pathogenic MSH2 P43246 S448I 448 S I 0.334 Neutral MSH2 P43246 S448K 448 S K 0.396 Neutral MSH2 P43246 S448L 448 S L 0.176 Neutral MSH2 P43246 S448M 448 S M 0.912 Pathogenic MSH2 P43246 S448N 448 S N 0.026 Neutral MSH2 P43246 S448P 448 S P 0.49 Neutral MSH2 P43246 S448Q 448 S Q 0.404 Neutral MSH2 P43246 S448R 448 S R 0.522 Pathogenic MSH2 P43246 S448T 448 S T 0.036 Neutral MSH2 P43246 S448V 448 S V 0.064 Neutral MSH2 P43246 S448W 448 S W 0.916 Pathogenic MSH2 P43246 S448Y 448 S Y 0.89 Pathogenic MSH2 P43246 K449A 449 K A 0.614 Pathogenic MSH2 P43246 K449C 449 K C 0.498 Neutral MSH2 P43246 K449D 449 K D 0.288 Neutral MSH2 P43246 K449E 449 K E 0.216 Neutral MSH2 P43246 K449F 449 K F 0.972 Pathogenic MSH2 P43246 K449G 449 K G 0.162 Neutral MSH2 P43246 K449H 449 K H 0.812 Pathogenic MSH2 P43246 K449I 449 K I 0.988 Pathogenic MSH2 P43246 K449L 449 K L 0.468 Neutral MSH2 P43246 K449M 449 K M 0.2 Neutral MSH2 P43246 K449N 449 K N 0.162 Neutral MSH2 P43246 K449P 449 K P 0.36 Neutral MSH2 P43246 K449Q 449 K Q 0.168 Neutral MSH2 P43246 K449R 449 K R 0.188 Neutral MSH2 P43246 K449S 449 K S 0.726 Pathogenic MSH2 P43246 K449T 449 K T 0.304 Neutral MSH2 P43246 K449V 449 K V 0.888 Pathogenic MSH2 P43246 K449W 449 K W 0.992 Pathogenic MSH2 P43246 K449Y 449 K Y 0.984 Pathogenic MSH2 P43246 A45C 45 A C 0.166 Neutral MSH2 P43246 A45D 45 A D 0.84 Pathogenic MSH2 P43246 A45E 45 A E 0.86 Pathogenic MSH2 P43246 A45F 45 A F 0.714 Pathogenic MSH2 P43246 A45G 45 A G 0.508 Pathogenic MSH2 P43246 A45H 45 A H 0.85 Pathogenic MSH2 P43246 A45I 45 A I 0.628 Pathogenic MSH2 P43246 A45K 45 A K 0.896 Pathogenic MSH2 P43246 A45L 45 A L 0.572 Pathogenic MSH2 P43246 A45M 45 A M 0.784 Pathogenic MSH2 P43246 A45N 45 A N 0.762 Pathogenic MSH2 P43246 A45P 45 A P 0.928 Pathogenic MSH2 P43246 A45Q 45 A Q 0.78 Pathogenic MSH2 P43246 A45R 45 A R 0.868 Pathogenic MSH2 P43246 A45S 45 A S 0.014 Neutral MSH2 P43246 A45T 45 A T 0.042 Neutral MSH2 P43246 A45V 45 A V 0.142 Neutral MSH2 P43246 A45W 45 A W 0.948 Pathogenic MSH2 P43246 A45Y 45 A Y 0.932 Pathogenic MSH2 P43246 F450A 450 F A 0.414 Neutral MSH2 P43246 F450C 450 F C 0.58 Pathogenic MSH2 P43246 F450D 450 F D 0.79 Pathogenic MSH2 P43246 F450E 450 F E 0.498 Neutral MSH2 P43246 F450G 450 F G 0.486 Neutral MSH2 P43246 F450H 450 F H 0.634 Pathogenic MSH2 P43246 F450I 450 F I 0.224 Neutral MSH2 P43246 F450K 450 F K 0.854 Pathogenic MSH2 P43246 F450L 450 F L 0.076 Neutral MSH2 P43246 F450M 450 F M 0.156 Neutral MSH2 P43246 F450N 450 F N 0.71 Pathogenic MSH2 P43246 F450P 450 F P 0.488 Neutral MSH2 P43246 F450Q 450 F Q 0.742 Pathogenic MSH2 P43246 F450R 450 F R 0.92 Pathogenic MSH2 P43246 F450S 450 F S 0.768 Pathogenic MSH2 P43246 F450T 450 F T 0.362 Neutral MSH2 P43246 F450V 450 F V 0.426 Neutral MSH2 P43246 F450W 450 F W 0.944 Pathogenic MSH2 P43246 F450Y 450 F Y 0.26 Neutral MSH2 P43246 Q451A 451 Q A 0.124 Neutral MSH2 P43246 Q451C 451 Q C 0.122 Neutral MSH2 P43246 Q451D 451 Q D 0.058 Neutral MSH2 P43246 Q451E 451 Q E 0.03 Neutral MSH2 P43246 Q451F 451 Q F 0.81 Pathogenic MSH2 P43246 Q451G 451 Q G 0.13 Neutral MSH2 P43246 Q451H 451 Q H 0.782 Pathogenic MSH2 P43246 Q451I 451 Q I 0.326 Neutral MSH2 P43246 Q451K 451 Q K 0.066 Neutral MSH2 P43246 Q451L 451 Q L 0.212 Neutral MSH2 P43246 Q451M 451 Q M 0.708 Pathogenic MSH2 P43246 Q451N 451 Q N 0.17 Neutral MSH2 P43246 Q451P 451 Q P 0.836 Pathogenic MSH2 P43246 Q451R 451 Q R 0.274 Neutral MSH2 P43246 Q451S 451 Q S 0.1 Neutral MSH2 P43246 Q451T 451 Q T 0.05 Neutral MSH2 P43246 Q451V 451 Q V 0.102 Neutral MSH2 P43246 Q451W 451 Q W 0.93 Pathogenic MSH2 P43246 Q451Y 451 Q Y 0.89 Pathogenic MSH2 P43246 E452A 452 E A 0.24 Neutral MSH2 P43246 E452C 452 E C 0.648 Pathogenic MSH2 P43246 E452D 452 E D 0.112 Neutral MSH2 P43246 E452F 452 E F 0.838 Pathogenic MSH2 P43246 E452G 452 E G 0.096 Neutral MSH2 P43246 E452H 452 E H 0.838 Pathogenic MSH2 P43246 E452I 452 E I 0.98 Pathogenic MSH2 P43246 E452K 452 E K 0.4 Neutral MSH2 P43246 E452L 452 E L 0.742 Pathogenic MSH2 P43246 E452M 452 E M 0.684 Pathogenic MSH2 P43246 E452N 452 E N 0.084 Neutral MSH2 P43246 E452P 452 E P 0.93 Pathogenic MSH2 P43246 E452Q 452 E Q 0.066 Neutral MSH2 P43246 E452R 452 E R 0.416 Neutral MSH2 P43246 E452S 452 E S 0.156 Neutral MSH2 P43246 E452T 452 E T 0.854 Pathogenic MSH2 P43246 E452V 452 E V 0.66 Pathogenic MSH2 P43246 E452W 452 E W 0.986 Pathogenic MSH2 P43246 E452Y 452 E Y 0.966 Pathogenic MSH2 P43246 M453A 453 M A 0.684 Pathogenic MSH2 P43246 M453C 453 M C 0.236 Neutral MSH2 P43246 M453D 453 M D 0.85 Pathogenic MSH2 P43246 M453E 453 M E 0.798 Pathogenic MSH2 P43246 M453F 453 M F 0.702 Pathogenic MSH2 P43246 M453G 453 M G 0.532 Pathogenic MSH2 P43246 M453H 453 M H 0.432 Neutral MSH2 P43246 M453I 453 M I 0.508 Pathogenic MSH2 P43246 M453K 453 M K 0.564 Pathogenic MSH2 P43246 M453L 453 M L 0.242 Neutral MSH2 P43246 M453N 453 M N 0.888 Pathogenic MSH2 P43246 M453P 453 M P 0.918 Pathogenic MSH2 P43246 M453Q 453 M Q 0.782 Pathogenic MSH2 P43246 M453R 453 M R 0.938 Pathogenic MSH2 P43246 M453S 453 M S 0.908 Pathogenic MSH2 P43246 M453T 453 M T 0.748 Pathogenic MSH2 P43246 M453V 453 M V 0.576 Pathogenic MSH2 P43246 M453W 453 M W 0.934 Pathogenic MSH2 P43246 M453Y 453 M Y 0.95 Pathogenic MSH2 P43246 I454A 454 I A 0.22 Neutral MSH2 P43246 I454C 454 I C 0.684 Pathogenic MSH2 P43246 I454D 454 I D 0.47 Neutral MSH2 P43246 I454E 454 I E 0.756 Pathogenic MSH2 P43246 I454F 454 I F 0.926 Pathogenic MSH2 P43246 I454G 454 I G 0.492 Neutral MSH2 P43246 I454H 454 I H 0.902 Pathogenic MSH2 P43246 I454K 454 I K 0.848 Pathogenic MSH2 P43246 I454L 454 I L 0.088 Neutral MSH2 P43246 I454M 454 I M 0.696 Pathogenic MSH2 P43246 I454N 454 I N 0.778 Pathogenic MSH2 P43246 I454P 454 I P 0.932 Pathogenic MSH2 P43246 I454Q 454 I Q 0.788 Pathogenic MSH2 P43246 I454R 454 I R 0.864 Pathogenic MSH2 P43246 I454S 454 I S 0.66 Pathogenic MSH2 P43246 I454T 454 I T 0.332 Neutral MSH2 P43246 I454V 454 I V 0.224 Neutral MSH2 P43246 I454W 454 I W 0.734 Pathogenic MSH2 P43246 I454Y 454 I Y 0.952 Pathogenic MSH2 P43246 E455A 455 E A 0.802 Pathogenic MSH2 P43246 E455C 455 E C 0.746 Pathogenic MSH2 P43246 E455D 455 E D 0.272 Neutral MSH2 P43246 E455F 455 E F 0.834 Pathogenic MSH2 P43246 E455G 455 E G 0.344 Neutral MSH2 P43246 E455H 455 E H 0.544 Pathogenic MSH2 P43246 E455I 455 E I 0.972 Pathogenic MSH2 P43246 E455K 455 E K 0.886 Pathogenic MSH2 P43246 E455L 455 E L 0.714 Pathogenic MSH2 P43246 E455M 455 E M 0.894 Pathogenic MSH2 P43246 E455N 455 E N 0.358 Neutral MSH2 P43246 E455P 455 E P 0.932 Pathogenic MSH2 P43246 E455Q 455 E Q 0.242 Neutral MSH2 P43246 E455R 455 E R 0.616 Pathogenic MSH2 P43246 E455S 455 E S 0.216 Neutral MSH2 P43246 E455T 455 E T 0.838 Pathogenic MSH2 P43246 E455V 455 E V 0.48 Neutral MSH2 P43246 E455W 455 E W 0.974 Pathogenic MSH2 P43246 E455Y 455 E Y 0.954 Pathogenic MSH2 P43246 T456A 456 T A 0.12 Neutral MSH2 P43246 T456C 456 T C 0.384 Neutral MSH2 P43246 T456D 456 T D 0.204 Neutral MSH2 P43246 T456E 456 T E 0.336 Neutral MSH2 P43246 T456F 456 T F 0.894 Pathogenic MSH2 P43246 T456G 456 T G 0.156 Neutral MSH2 P43246 T456H 456 T H 0.55 Pathogenic MSH2 P43246 T456I 456 T I 0.836 Pathogenic MSH2 P43246 T456K 456 T K 0.34 Neutral MSH2 P43246 T456L 456 T L 0.366 Neutral MSH2 P43246 T456M 456 T M 0.674 Pathogenic MSH2 P43246 T456N 456 T N 0.704 Pathogenic MSH2 P43246 T456P 456 T P 0.864 Pathogenic MSH2 P43246 T456Q 456 T Q 0.142 Neutral MSH2 P43246 T456R 456 T R 0.692 Pathogenic MSH2 P43246 T456S 456 T S 0.068 Neutral MSH2 P43246 T456V 456 T V 0.682 Pathogenic MSH2 P43246 T456W 456 T W 0.954 Pathogenic MSH2 P43246 T456Y 456 T Y 0.912 Pathogenic MSH2 P43246 T457A 457 T A 0.194 Neutral MSH2 P43246 T457C 457 T C 0.364 Neutral MSH2 P43246 T457D 457 T D 0.944 Pathogenic MSH2 P43246 T457E 457 T E 0.948 Pathogenic MSH2 P43246 T457F 457 T F 0.948 Pathogenic MSH2 P43246 T457G 457 T G 0.73 Pathogenic MSH2 P43246 T457H 457 T H 0.914 Pathogenic MSH2 P43246 T457I 457 T I 0.396 Neutral MSH2 P43246 T457K 457 T K 0.938 Pathogenic MSH2 P43246 T457L 457 T L 0.62 Pathogenic MSH2 P43246 T457M 457 T M 0.726 Pathogenic MSH2 P43246 T457N 457 T N 0.882 Pathogenic MSH2 P43246 T457P 457 T P 0.64 Pathogenic MSH2 P43246 T457Q 457 T Q 0.878 Pathogenic MSH2 P43246 T457R 457 T R 0.72 Pathogenic MSH2 P43246 T457S 457 T S 0.176 Neutral MSH2 P43246 T457V 457 T V 0.282 Neutral MSH2 P43246 T457W 457 T W 0.892 Pathogenic MSH2 P43246 T457Y 457 T Y 0.988 Pathogenic MSH2 P43246 L458A 458 L A 0.562 Pathogenic MSH2 P43246 L458C 458 L C 0.68 Pathogenic MSH2 P43246 L458D 458 L D 0.9 Pathogenic MSH2 P43246 L458E 458 L E 0.5 Pathogenic MSH2 P43246 L458F 458 L F 0.976 Pathogenic MSH2 P43246 L458G 458 L G 0.804 Pathogenic MSH2 P43246 L458H 458 L H 0.798 Pathogenic MSH2 P43246 L458I 458 L I 0.128 Neutral MSH2 P43246 L458K 458 L K 0.748 Pathogenic MSH2 P43246 L458M 458 L M 0.186 Neutral MSH2 P43246 L458N 458 L N 0.77 Pathogenic MSH2 P43246 L458P 458 L P 0.998 Pathogenic MSH2 P43246 L458Q 458 L Q 0.614 Pathogenic MSH2 P43246 L458R 458 L R 0.994 Pathogenic MSH2 P43246 L458S 458 L S 0.182 Neutral MSH2 P43246 L458T 458 L T 0.59 Pathogenic MSH2 P43246 L458V 458 L V 0.206 Neutral MSH2 P43246 L458W 458 L W 0.94 Pathogenic MSH2 P43246 L458Y 458 L Y 0.902 Pathogenic MSH2 P43246 D459A 459 D A 0.784 Pathogenic MSH2 P43246 D459C 459 D C 0.702 Pathogenic MSH2 P43246 D459E 459 D E 0.658 Pathogenic MSH2 P43246 D459F 459 D F 0.974 Pathogenic MSH2 P43246 D459G 459 D G 0.92 Pathogenic MSH2 P43246 D459H 459 D H 0.622 Pathogenic MSH2 P43246 D459I 459 D I 0.962 Pathogenic MSH2 P43246 D459K 459 D K 0.92 Pathogenic MSH2 P43246 D459L 459 D L 0.964 Pathogenic MSH2 P43246 D459M 459 D M 0.948 Pathogenic MSH2 P43246 D459N 459 D N 0.51 Pathogenic MSH2 P43246 D459P 459 D P 0.892 Pathogenic MSH2 P43246 D459Q 459 D Q 0.612 Pathogenic MSH2 P43246 D459R 459 D R 0.956 Pathogenic MSH2 P43246 D459S 459 D S 0.558 Pathogenic MSH2 P43246 D459T 459 D T 0.58 Pathogenic MSH2 P43246 D459V 459 D V 0.982 Pathogenic MSH2 P43246 D459W 459 D W 0.978 Pathogenic MSH2 P43246 D459Y 459 D Y 0.934 Pathogenic MSH2 P43246 H46A 46 H A 0.662 Pathogenic MSH2 P43246 H46C 46 H C 0.622 Pathogenic MSH2 P43246 H46D 46 H D 0.568 Pathogenic MSH2 P43246 H46E 46 H E 0.754 Pathogenic MSH2 P43246 H46F 46 H F 0.79 Pathogenic MSH2 P43246 H46G 46 H G 0.506 Pathogenic MSH2 P43246 H46I 46 H I 0.376 Neutral MSH2 P43246 H46K 46 H K 0.818 Pathogenic MSH2 P43246 H46L 46 H L 0.364 Neutral MSH2 P43246 H46M 46 H M 0.812 Pathogenic MSH2 P43246 H46N 46 H N 0.178 Neutral MSH2 P43246 H46P 46 H P 0.984 Pathogenic MSH2 P43246 H46Q 46 H Q 0.788 Pathogenic MSH2 P43246 H46R 46 H R 0.38 Neutral MSH2 P43246 H46S 46 H S 0.752 Pathogenic MSH2 P43246 H46T 46 H T 0.704 Pathogenic MSH2 P43246 H46V 46 H V 0.228 Neutral MSH2 P43246 H46W 46 H W 0.992 Pathogenic MSH2 P43246 H46Y 46 H Y 0.43 Neutral MSH2 P43246 M460A 460 M A 0.666 Pathogenic MSH2 P43246 M460C 460 M C 0.602 Pathogenic MSH2 P43246 M460D 460 M D 0.878 Pathogenic MSH2 P43246 M460E 460 M E 0.814 Pathogenic MSH2 P43246 M460F 460 M F 0.34 Neutral MSH2 P43246 M460G 460 M G 0.304 Neutral MSH2 P43246 M460H 460 M H 0.924 Pathogenic MSH2 P43246 M460I 460 M I 0.508 Pathogenic MSH2 P43246 M460K 460 M K 0.956 Pathogenic MSH2 P43246 M460L 460 M L 0.226 Neutral MSH2 P43246 M460N 460 M N 0.906 Pathogenic MSH2 P43246 M460P 460 M P 0.932 Pathogenic MSH2 P43246 M460Q 460 M Q 0.782 Pathogenic MSH2 P43246 M460R 460 M R 0.958 Pathogenic MSH2 P43246 M460S 460 M S 0.896 Pathogenic MSH2 P43246 M460T 460 M T 0.354 Neutral MSH2 P43246 M460V 460 M V 0.206 Neutral MSH2 P43246 M460W 460 M W 0.996 Pathogenic MSH2 P43246 M460Y 460 M Y 0.978 Pathogenic MSH2 P43246 D461A 461 D A 0.192 Neutral MSH2 P43246 D461C 461 D C 0.722 Pathogenic MSH2 P43246 D461E 461 D E 0.186 Neutral MSH2 P43246 D461F 461 D F 0.926 Pathogenic MSH2 P43246 D461G 461 D G 0.22 Neutral MSH2 P43246 D461H 461 D H 0.346 Neutral MSH2 P43246 D461I 461 D I 0.91 Pathogenic MSH2 P43246 D461K 461 D K 0.318 Neutral MSH2 P43246 D461L 461 D L 0.898 Pathogenic MSH2 P43246 D461M 461 D M 0.822 Pathogenic MSH2 P43246 D461N 461 D N 0.066 Neutral MSH2 P43246 D461P 461 D P 0.804 Pathogenic MSH2 P43246 D461Q 461 D Q 0.14 Neutral MSH2 P43246 D461R 461 D R 0.59 Pathogenic MSH2 P43246 D461S 461 D S 0.116 Neutral MSH2 P43246 D461T 461 D T 0.162 Neutral MSH2 P43246 D461V 461 D V 0.922 Pathogenic MSH2 P43246 D461W 461 D W 0.898 Pathogenic MSH2 P43246 D461Y 461 D Y 0.932 Pathogenic MSH2 P43246 Q462A 462 Q A 0.144 Neutral MSH2 P43246 Q462C 462 Q C 0.122 Neutral MSH2 P43246 Q462D 462 Q D 0.064 Neutral MSH2 P43246 Q462E 462 Q E 0.112 Neutral MSH2 P43246 Q462F 462 Q F 0.34 Neutral MSH2 P43246 Q462G 462 Q G 0.138 Neutral MSH2 P43246 Q462H 462 Q H 0.274 Neutral MSH2 P43246 Q462I 462 Q I 0.36 Neutral MSH2 P43246 Q462K 462 Q K 0.026 Neutral MSH2 P43246 Q462L 462 Q L 0.392 Neutral MSH2 P43246 Q462M 462 Q M 0.254 Neutral MSH2 P43246 Q462N 462 Q N 0.126 Neutral MSH2 P43246 Q462P 462 Q P 0.37 Neutral MSH2 P43246 Q462R 462 Q R 0.012 Neutral MSH2 P43246 Q462S 462 Q S 0.208 Neutral MSH2 P43246 Q462T 462 Q T 0.074 Neutral MSH2 P43246 Q462V 462 Q V 0.342 Neutral MSH2 P43246 Q462W 462 Q W 0.594 Pathogenic MSH2 P43246 Q462Y 462 Q Y 0.514 Pathogenic MSH2 P43246 V463A 463 V A 0.016 Neutral MSH2 P43246 V463C 463 V C 0.386 Neutral MSH2 P43246 V463D 463 V D 0.596 Pathogenic MSH2 P43246 V463E 463 V E 0.7 Pathogenic MSH2 P43246 V463F 463 V F 0.624 Pathogenic MSH2 P43246 V463G 463 V G 0.622 Pathogenic MSH2 P43246 V463H 463 V H 0.532 Pathogenic MSH2 P43246 V463I 463 V I 0.044 Neutral MSH2 P43246 V463K 463 V K 0.644 Pathogenic MSH2 P43246 V463L 463 V L 0.054 Neutral MSH2 P43246 V463M 463 V M 0.074 Neutral MSH2 P43246 V463N 463 V N 0.632 Pathogenic MSH2 P43246 V463P 463 V P 0.86 Pathogenic MSH2 P43246 V463Q 463 V Q 0.536 Pathogenic MSH2 P43246 V463R 463 V R 0.838 Pathogenic MSH2 P43246 V463S 463 V S 0.272 Neutral MSH2 P43246 V463T 463 V T 0.164 Neutral MSH2 P43246 V463W 463 V W 0.838 Pathogenic MSH2 P43246 V463Y 463 V Y 0.478 Neutral MSH2 P43246 E464A 464 E A 0.254 Neutral MSH2 P43246 E464C 464 E C 0.584 Pathogenic MSH2 P43246 E464D 464 E D 0.086 Neutral MSH2 P43246 E464F 464 E F 0.872 Pathogenic MSH2 P43246 E464G 464 E G 0.108 Neutral MSH2 P43246 E464H 464 E H 0.612 Pathogenic MSH2 P43246 E464I 464 E I 0.81 Pathogenic MSH2 P43246 E464K 464 E K 0.324 Neutral MSH2 P43246 E464L 464 E L 0.9 Pathogenic MSH2 P43246 E464M 464 E M 0.732 Pathogenic MSH2 P43246 E464N 464 E N 0.142 Neutral MSH2 P43246 E464P 464 E P 0.88 Pathogenic MSH2 P43246 E464Q 464 E Q 0.082 Neutral MSH2 P43246 E464R 464 E R 0.47 Neutral MSH2 P43246 E464S 464 E S 0.166 Neutral MSH2 P43246 E464T 464 E T 0.194 Neutral MSH2 P43246 E464V 464 E V 0.872 Pathogenic MSH2 P43246 E464W 464 E W 0.938 Pathogenic MSH2 P43246 E464Y 464 E Y 0.906 Pathogenic MSH2 P43246 N465A 465 N A 0.092 Neutral MSH2 P43246 N465C 465 N C 0.608 Pathogenic MSH2 P43246 N465D 465 N D 0.58 Pathogenic MSH2 P43246 N465E 465 N E 0.066 Neutral MSH2 P43246 N465F 465 N F 0.922 Pathogenic MSH2 P43246 N465G 465 N G 0.486 Neutral MSH2 P43246 N465H 465 N H 0.058 Neutral MSH2 P43246 N465I 465 N I 0.36 Neutral MSH2 P43246 N465K 465 N K 0.09 Neutral MSH2 P43246 N465L 465 N L 0.152 Neutral MSH2 P43246 N465M 465 N M 0.862 Pathogenic MSH2 P43246 N465P 465 N P 0.774 Pathogenic MSH2 P43246 N465Q 465 N Q 0.056 Neutral MSH2 P43246 N465R 465 N R 0.454 Neutral MSH2 P43246 N465S 465 N S 0.06 Neutral MSH2 P43246 N465T 465 N T 0.294 Neutral MSH2 P43246 N465V 465 N V 0.806 Pathogenic MSH2 P43246 N465W 465 N W 0.956 Pathogenic MSH2 P43246 N465Y 465 N Y 0.754 Pathogenic MSH2 P43246 H466A 466 H A 0.092 Neutral MSH2 P43246 H466C 466 H C 0.076 Neutral MSH2 P43246 H466D 466 H D 0.058 Neutral MSH2 P43246 H466E 466 H E 0.094 Neutral MSH2 P43246 H466F 466 H F 0.358 Neutral MSH2 P43246 H466G 466 H G 0.178 Neutral MSH2 P43246 H466I 466 H I 0.418 Neutral MSH2 P43246 H466K 466 H K 0.186 Neutral MSH2 P43246 H466L 466 H L 0.368 Neutral MSH2 P43246 H466M 466 H M 0.192 Neutral MSH2 P43246 H466N 466 H N 0.086 Neutral MSH2 P43246 H466P 466 H P 0.46 Neutral MSH2 P43246 H466Q 466 H Q 0.13 Neutral MSH2 P43246 H466R 466 H R 0.08 Neutral MSH2 P43246 H466S 466 H S 0.296 Neutral MSH2 P43246 H466T 466 H T 0.238 Neutral MSH2 P43246 H466V 466 H V 0.228 Neutral MSH2 P43246 H466W 466 H W 0.646 Pathogenic MSH2 P43246 H466Y 466 H Y 0.488 Neutral MSH2 P43246 E467A 467 E A 0.196 Neutral MSH2 P43246 E467C 467 E C 0.126 Neutral MSH2 P43246 E467D 467 E D 0.14 Neutral MSH2 P43246 E467F 467 E F 0.436 Neutral MSH2 P43246 E467G 467 E G 0.072 Neutral MSH2 P43246 E467H 467 E H 0.174 Neutral MSH2 P43246 E467I 467 E I 0.47 Neutral MSH2 P43246 E467K 467 E K 0.292 Neutral MSH2 P43246 E467L 467 E L 0.48 Neutral MSH2 P43246 E467M 467 E M 0.298 Neutral MSH2 P43246 E467N 467 E N 0.092 Neutral MSH2 P43246 E467P 467 E P 0.466 Neutral MSH2 P43246 E467Q 467 E Q 0.088 Neutral MSH2 P43246 E467R 467 E R 0.124 Neutral MSH2 P43246 E467S 467 E S 0.23 Neutral MSH2 P43246 E467T 467 E T 0.282 Neutral MSH2 P43246 E467V 467 E V 0.416 Neutral MSH2 P43246 E467W 467 E W 0.708 Pathogenic MSH2 P43246 E467Y 467 E Y 0.588 Pathogenic MSH2 P43246 F468A 468 F A 0.51 Pathogenic MSH2 P43246 F468C 468 F C 0.718 Pathogenic MSH2 P43246 F468D 468 F D 0.8 Pathogenic MSH2 P43246 F468E 468 F E 0.848 Pathogenic MSH2 P43246 F468G 468 F G 0.494 Neutral MSH2 P43246 F468H 468 F H 0.366 Neutral MSH2 P43246 F468I 468 F I 0.678 Pathogenic MSH2 P43246 F468K 468 F K 0.836 Pathogenic MSH2 P43246 F468L 468 F L 0.694 Pathogenic MSH2 P43246 F468M 468 F M 0.78 Pathogenic MSH2 P43246 F468N 468 F N 0.72 Pathogenic MSH2 P43246 F468P 468 F P 0.482 Neutral MSH2 P43246 F468Q 468 F Q 0.732 Pathogenic MSH2 P43246 F468R 468 F R 0.902 Pathogenic MSH2 P43246 F468S 468 F S 0.834 Pathogenic MSH2 P43246 F468T 468 F T 0.572 Pathogenic MSH2 P43246 F468V 468 F V 0.352 Neutral MSH2 P43246 F468W 468 F W 0.744 Pathogenic MSH2 P43246 F468Y 468 F Y 0.272 Neutral MSH2 P43246 L469A 469 L A 0.12 Neutral MSH2 P43246 L469C 469 L C 0.42 Neutral MSH2 P43246 L469D 469 L D 0.66 Pathogenic MSH2 P43246 L469E 469 L E 0.62 Pathogenic MSH2 P43246 L469F 469 L F 0.484 Neutral MSH2 P43246 L469G 469 L G 0.57 Pathogenic MSH2 P43246 L469H 469 L H 0.456 Neutral MSH2 P43246 L469I 469 L I 0.044 Neutral MSH2 P43246 L469K 469 L K 0.362 Neutral MSH2 P43246 L469M 469 L M 0.024 Neutral MSH2 P43246 L469N 469 L N 0.606 Pathogenic MSH2 P43246 L469P 469 L P 0.882 Pathogenic MSH2 P43246 L469Q 469 L Q 0.196 Neutral MSH2 P43246 L469R 469 L R 0.546 Pathogenic MSH2 P43246 L469S 469 L S 0.142 Neutral MSH2 P43246 L469T 469 L T 0.334 Neutral MSH2 P43246 L469V 469 L V 0.016 Neutral MSH2 P43246 L469W 469 L W 0.81 Pathogenic MSH2 P43246 L469Y 469 L Y 0.796 Pathogenic MSH2 P43246 G47A 47 G A 0.634 Pathogenic MSH2 P43246 G47C 47 G C 0.942 Pathogenic MSH2 P43246 G47D 47 G D 0.636 Pathogenic MSH2 P43246 G47E 47 G E 0.594 Pathogenic MSH2 P43246 G47F 47 G F 0.978 Pathogenic MSH2 P43246 G47H 47 G H 0.864 Pathogenic MSH2 P43246 G47I 47 G I 0.97 Pathogenic MSH2 P43246 G47K 47 G K 0.982 Pathogenic MSH2 P43246 G47L 47 G L 0.98 Pathogenic MSH2 P43246 G47M 47 G M 0.994 Pathogenic MSH2 P43246 G47N 47 G N 0.684 Pathogenic MSH2 P43246 G47P 47 G P 0.946 Pathogenic MSH2 P43246 G47Q 47 G Q 0.99 Pathogenic MSH2 P43246 G47R 47 G R 0.742 Pathogenic MSH2 P43246 G47S 47 G S 0.296 Neutral MSH2 P43246 G47T 47 G T 0.816 Pathogenic MSH2 P43246 G47V 47 G V 0.982 Pathogenic MSH2 P43246 G47W 47 G W 0.974 Pathogenic MSH2 P43246 G47Y 47 G Y 0.94 Pathogenic MSH2 P43246 V470A 470 V A 0.498 Neutral MSH2 P43246 V470C 470 V C 0.79 Pathogenic MSH2 P43246 V470D 470 V D 0.844 Pathogenic MSH2 P43246 V470E 470 V E 0.952 Pathogenic MSH2 P43246 V470F 470 V F 0.692 Pathogenic MSH2 P43246 V470G 470 V G 0.924 Pathogenic 4 MSH2 P43246 V470H 470 V H 0.896 Pathogenic MSH2 P43246 V470I 470 V I 0.212 Neutral MSH2 P43246 V470K 470 V K 0.97 Pathogenic MSH2 P43246 V470L 470 V L 0.564 Pathogenic MSH2 P43246 V470M 470 V M 0.904 Pathogenic MSH2 P43246 V470N 470 V N 0.904 Pathogenic MSH2 P43246 V470P 470 V P 0.978 Pathogenic MSH2 P43246 V470Q 470 V Q 0.96 Pathogenic MSH2 P43246 V470R 470 V R 0.944 Pathogenic MSH2 P43246 V470S 470 V S 0.418 Neutral MSH2 P43246 V470T 470 V T 0.872 Pathogenic MSH2 P43246 V470W 470 V W 0.956 Pathogenic MSH2 P43246 V470Y 470 V Y 0.976 Pathogenic MSH2 P43246 K471A 471 K A 0.238 Neutral MSH2 P43246 K471C 471 K C 0.154 Neutral MSH2 P43246 K471D 471 K D 0.766 Pathogenic MSH2 P43246 K471E 471 K E 0.874 Pathogenic MSH2 P43246 K471F 471 K F 0.97 Pathogenic MSH2 P43246 K471G 471 K G 0.542 Pathogenic MSH2 P43246 K471H 471 K H 0.876 Pathogenic MSH2 P43246 K471I 471 K I 0.992 Pathogenic MSH2 P43246 K471L 471 K L 0.458 Neutral MSH2 P43246 K471M 471 K M 0.908 Pathogenic MSH2 P43246 K471N 471 K N 0.196 Neutral MSH2 P43246 K471P 471 K P 0.922 Pathogenic MSH2 P43246 K471Q 471 K Q 0.39 Neutral MSH2 P43246 K471R 471 K R 0.228 Neutral MSH2 P43246 K471S 471 K S 0.104 Neutral MSH2 P43246 K471T 471 K T 0.66 Pathogenic MSH2 P43246 K471V 471 K V 0.884 Pathogenic MSH2 P43246 K471W 471 K W 0.99 Pathogenic MSH2 P43246 K471Y 471 K Y 0.856 Pathogenic MSH2 P43246 P472A 472 P A 0.162 Neutral MSH2 P43246 P472C 472 P C 0.192 Neutral MSH2 P43246 P472D 472 P D 0.792 Pathogenic MSH2 P43246 P472E 472 P E 0.97 Pathogenic MSH2 P43246 P472F 472 P F 0.998 Pathogenic MSH2 P43246 P472G 472 P G 0.516 Pathogenic MSH2 P43246 P472H 472 P H 0.982 Pathogenic MSH2 P43246 P472I 472 P I 0.928 Pathogenic MSH2 P43246 P472K 472 P K 0.96 Pathogenic MSH2 P43246 P472L 472 P L 0.428 Neutral MSH2 P43246 P472M 472 P M 0.964 Pathogenic MSH2 P43246 P472N 472 P N 0.646 Pathogenic MSH2 P43246 P472Q 472 P Q 0.858 Pathogenic MSH2 P43246 P472R 472 P R 0.986 Pathogenic MSH2 P43246 P472S 472 P S 0.082 Neutral MSH2 P43246 P472T 472 P T 0.684 Pathogenic MSH2 P43246 P472V 472 P V 0.154 Neutral MSH2 P43246 P472W 472 P W 0.946 Pathogenic MSH2 P43246 P472Y 472 P Y 0.946 Pathogenic MSH2 P43246 S473A 473 S A 0.274 Neutral MSH2 P43246 S473C 473 S C 0.656 Pathogenic MSH2 P43246 S473D 473 S D 0.21 Neutral MSH2 P43246 S473E 473 S E 0.49 Neutral MSH2 P43246 S473F 473 S F 0.936 Pathogenic MSH2 P43246 S473G 473 S G 0.09 Neutral MSH2 P43246 S473H 473 S H 0.876 Pathogenic MSH2 P43246 S473I 473 S I 0.756 Pathogenic MSH2 P43246 S473K 473 S K 0.832 Pathogenic MSH2 P43246 S473L 473 S L 0.498 Neutral MSH2 P43246 S473M 473 S M 0.952 Pathogenic MSH2 P43246 S473N 473 S N 0.662 Pathogenic MSH2 P43246 S473P 473 S P 0.816 Pathogenic MSH2 P43246 S473Q 473 S Q 0.536 Pathogenic MSH2 P43246 S473R 473 S R 0.608 Pathogenic MSH2 P43246 S473T 473 S T 0.256 Neutral MSH2 P43246 S473V 473 S V 0.8 Pathogenic MSH2 P43246 S473W 473 S W 0.888 Pathogenic MSH2 P43246 S473Y 473 S Y 0.886 Pathogenic MSH2 P43246 F474A 474 F A 0.496 Neutral MSH2 P43246 F474C 474 F C 0.716 Pathogenic MSH2 P43246 F474D 474 F D 0.794 Pathogenic MSH2 P43246 F474E 474 F E 0.838 Pathogenic MSH2 P43246 F474G 474 F G 0.5 Pathogenic MSH2 P43246 F474H 474 F H 0.376 Neutral MSH2 P43246 F474I 474 F I 0.204 Neutral MSH2 P43246 F474K 474 F K 0.816 Pathogenic MSH2 P43246 F474L 474 F L 0.682 Pathogenic MSH2 P43246 F474M 474 F M 0.768 Pathogenic MSH2 P43246 F474N 474 F N 0.738 Pathogenic MSH2 P43246 F474P 474 F P 0.944 Pathogenic MSH2 P43246 F474Q 474 F Q 0.75 Pathogenic MSH2 P43246 F474R 474 F R 0.886 Pathogenic MSH2 P43246 F474S 474 F S 0.852 Pathogenic MSH2 P43246 F474T 474 F T 0.548 Pathogenic MSH2 P43246 F474V 474 F V 0.696 Pathogenic MSH2 P43246 F474W 474 F W 0.832 Pathogenic MSH2 P43246 F474Y 474 F Y 0.222 Neutral MSH2 P43246 D475A 475 D A 0.308 Neutral MSH2 P43246 D475C 475 D C 0.846 Pathogenic MSH2 P43246 D475E 475 D E 0.448 Neutral MSH2 P43246 D475F 475 D F 0.972 Pathogenic MSH2 P43246 D475G 475 D G 0.908 Pathogenic MSH2 P43246 D475H 475 D H 0.34 Neutral MSH2 P43246 D475I 475 D I 0.964 Pathogenic MSH2 P43246 D475K 475 D K 0.518 Pathogenic MSH2 P43246 D475L 475 D L 0.96 Pathogenic MSH2 P43246 D475M 475 D M 0.94 Pathogenic MSH2 P43246 D475N 475 D N 0.198 Neutral MSH2 P43246 D475P 475 D P 0.872 Pathogenic MSH2 P43246 D475Q 475 D Q 0.526 Pathogenic MSH2 P43246 D475R 475 D R 0.95 Pathogenic MSH2 P43246 D475S 475 D S 0.086 Neutral MSH2 P43246 D475T 475 D T 0.358 Neutral MSH2 P43246 D475V 475 D V 0.984 Pathogenic MSH2 P43246 D475W 475 D W 0.976 Pathogenic MSH2 P43246 D475Y 475 D Y 0.966 Pathogenic MSH2 P43246 P476A 476 P A 0.076 Neutral MSH2 P43246 P476C 476 P C 0.658 Pathogenic MSH2 P43246 P476D 476 P D 0.044 Neutral MSH2 P43246 P476E 476 P E 0.158 Neutral MSH2 P43246 P476F 476 P F 0.97 Pathogenic MSH2 P43246 P476G 476 P G 0.154 Neutral MSH2 P43246 P476H 476 P H 0.868 Pathogenic MSH2 P43246 P476I 476 P I 0.79 Pathogenic MSH2 P43246 P476K 476 P K 0.174 Neutral MSH2 P43246 P476L 476 P L 0.61 Pathogenic MSH2 P43246 P476M 476 P M 0.754 Pathogenic MSH2 P43246 P476N 476 P N 0.196 Neutral MSH2 P43246 P476Q 476 P Q 0.15 Neutral MSH2 P43246 P476R 476 P R 0.584 Pathogenic MSH2 P43246 P476S 476 P S 0.02 Neutral MSH2 P43246 P476T 476 P T 0.174 Neutral MSH2 P43246 P476V 476 P V 0.646 Pathogenic MSH2 P43246 P476W 476 P W 0.908 Pathogenic MSH2 P43246 P476Y 476 P Y 0.886 Pathogenic MSH2 P43246 N477A 477 N A 0.048 Neutral MSH2 P43246 N477C 477 N C 0.542 Pathogenic MSH2 P43246 N477D 477 N D 0.026 Neutral MSH2 P43246 N477E 477 N E 0.034 Neutral MSH2 P43246 N477F 477 N F 0.842 Pathogenic MSH2 P43246 N477G 477 N G 0.048 Neutral MSH2 P43246 N477H 477 N H 0.18 Neutral MSH2 P43246 N477I 477 N I 0.402 Neutral MSH2 P43246 N477K 477 N K 0.072 Neutral MSH2 P43246 N477L 477 N L 0.794 Pathogenic MSH2 P43246 N477M 477 N M 0.758 Pathogenic MSH2 P43246 N477P 477 N P 0.7 Pathogenic MSH2 P43246 N477Q 477 N Q 0.028 Neutral MSH2 P43246 N477R 477 N R 0.39 Neutral MSH2 P43246 N477S 477 N S 0.024 Neutral MSH2 P43246 N477T 477 N T 0.024 Neutral MSH2 P43246 N477V 477 N V 0.104 Neutral MSH2 P43246 N477W 477 N W 0.914 Pathogenic MSH2 P43246 N477Y 477 N Y 0.93 Pathogenic MSH2 P43246 L478A 478 L A 0.716 Pathogenic MSH2 P43246 L478C 478 L C 0.83 Pathogenic MSH2 P43246 L478D 478 L D 0.912 Pathogenic MSH2 P43246 L478E 478 L E 0.894 Pathogenic MSH2 P43246 L478F 478 L F 0.708 Pathogenic MSH2 P43246 L478G 478 L G 0.862 Pathogenic MSH2 P43246 L478H 478 L H 0.908 Pathogenic MSH2 P43246 L478I 478 L I 0.94 Pathogenic MSH2 P43246 L478K 478 L K 0.732 Pathogenic MSH2 P43246 L478M 478 L M 0.448 Neutral MSH2 P43246 L478N 478 L N 0.822 Pathogenic MSH2 P43246 L478P 478 L P 0.986 Pathogenic MSH2 P43246 L478Q 478 L Q 0.778 Pathogenic MSH2 P43246 L478R 478 L R 0.982 Pathogenic MSH2 P43246 L478S 478 L S 0.506 Pathogenic MSH2 P43246 L478T 478 L T 0.636 Pathogenic MSH2 P43246 L478V 478 L V 0.456 Neutral MSH2 P43246 L478W 478 L W 0.886 Pathogenic MSH2 P43246 L478Y 478 L Y 0.896 Pathogenic MSH2 P43246 S479A 479 S A 0.086 Neutral MSH2 P43246 S479C 479 S C 0.442 Neutral MSH2 P43246 S479D 479 S D 0.478 Neutral MSH2 P43246 S479E 479 S E 0.464 Neutral MSH2 P43246 S479F 479 S F 0.864 Pathogenic MSH2 P43246 S479G 479 S G 0.07 Neutral MSH2 P43246 S479H 479 S H 0.778 Pathogenic MSH2 P43246 S479I 479 S I 0.574 Pathogenic MSH2 P43246 S479K 479 S K 0.448 Neutral MSH2 P43246 S479L 479 S L 0.202 Neutral MSH2 P43246 S479M 479 S M 0.594 Pathogenic MSH2 P43246 S479N 479 S N 0.414 Neutral MSH2 P43246 S479P 479 S P 0.592 Pathogenic MSH2 P43246 S479Q 479 S Q 0.468 Neutral MSH2 P43246 S479R 479 S R 0.466 Neutral MSH2 P43246 S479T 479 S T 0.07 Neutral MSH2 P43246 S479V 479 S V 0.812 Pathogenic MSH2 P43246 S479W 479 S W 0.948 Pathogenic MSH2 P43246 S479Y 479 S Y 0.928 Pathogenic MSH2 P43246 E48A 48 E A 0.156 Neutral MSH2 P43246 E48C 48 E C 0.322 Neutral MSH2 P43246 E48D 48 E D 0.026 Neutral MSH2 P43246 E48F 48 E F 0.696 Pathogenic MSH2 P43246 E48G 48 E G 0.152 Neutral MSH2 P43246 E48H 48 E H 0.464 Neutral MSH2 P43246 E48I 48 E I 0.798 Pathogenic MSH2 P43246 E48K 48 E K 0.036 Neutral MSH2 P43246 E48L 48 E L 0.744 Pathogenic MSH2 P43246 E48M 48 E M 0.56 Pathogenic MSH2 P43246 E48N 48 E N 0.062 Neutral MSH2 P43246 E48P 48 E P 0.098 Neutral MSH2 P43246 E48Q 48 E Q 0.026 Neutral MSH2 P43246 E48R 48 E R 0.12 Neutral MSH2 P43246 E48S 48 E S 0.066 Neutral MSH2 P43246 E48T 48 E T 0.07 Neutral MSH2 P43246 E48V 48 E V 0.728 Pathogenic MSH2 P43246 E48W 48 E W 0.87 Pathogenic MSH2 P43246 E48Y 48 E Y 0.778 Pathogenic MSH2 P43246 E480A 480 E A 0.264 Neutral MSH2 P43246 E480C 480 E C 0.446 Neutral MSH2 P43246 E480D 480 E D 0.038 Neutral MSH2 P43246 E480F 480 E F 0.8 Pathogenic MSH2 P43246 E480G 480 E G 0.072 Neutral MSH2 P43246 E480H 480 E H 0.656 Pathogenic MSH2 P43246 E480I 480 E I 0.226 Neutral MSH2 P43246 E480K 480 E K 0.068 Neutral MSH2 P43246 E480L 480 E L 0.196 Neutral MSH2 P43246 E480M 480 E M 0.684 Pathogenic MSH2 P43246 E480N 480 E N 0.044 Neutral MSH2 P43246 E480P 480 E P 0.852 Pathogenic MSH2 P43246 E480Q 480 E Q 0.032 Neutral MSH2 P43246 E480R 480 E R 0.138 Neutral MSH2 P43246 E480S 480 E S 0.058 Neutral MSH2 P43246 E480T 480 E T 0.05 Neutral MSH2 P43246 E480V 480 E V 0.124 Neutral MSH2 P43246 E480W 480 E W 0.94 Pathogenic MSH2 P43246 E480Y 480 E Y 0.866 Pathogenic MSH2 P43246 L481A 481 L A 0.184 Neutral MSH2 P43246 L481C 481 L C 0.118 Neutral MSH2 P43246 L481D 481 L D 0.894 Pathogenic MSH2 P43246 L481E 481 L E 0.876 Pathogenic MSH2 P43246 L481F 481 L F 0.648 Pathogenic MSH2 P43246 L481G 481 L G 0.798 Pathogenic MSH2 P43246 L481H 481 L H 0.796 Pathogenic MSH2 P43246 L481I 481 L I 0.104 Neutral MSH2 P43246 L481K 481 L K 0.424 Neutral MSH2 P43246 L481M 481 L M 0.204 Neutral MSH2 P43246 L481N 481 L N 0.762 Pathogenic MSH2 P43246 L481P 481 L P 0.998 Pathogenic MSH2 P43246 L481Q 481 L Q 0.612 Pathogenic MSH2 P43246 L481R 481 L R 0.706 Pathogenic MSH2 P43246 L481S 481 L S 0.608 Pathogenic MSH2 P43246 L481T 481 L T 0.128 Neutral MSH2 P43246 L481V 481 L V 0.092 Neutral MSH2 P43246 L481W 481 L W 0.73 Pathogenic MSH2 P43246 L481Y 481 L Y 0.658 Pathogenic MSH2 P43246 R482A 482 R A 0.158 Neutral MSH2 P43246 R482C 482 R C 0.434 Neutral MSH2 P43246 R482D 482 R D 0.862 Pathogenic MSH2 P43246 R482E 482 R E 0.826 Pathogenic MSH2 P43246 R482F 482 R F 0.972 Pathogenic MSH2 P43246 R482G 482 R G 0.406 Neutral MSH2 P43246 R482H 482 R H 0.188 Neutral MSH2 P43246 R482I 482 R I 0.974 Pathogenic MSH2 P43246 R482K 482 R K 0.366 Neutral MSH2 P43246 R482L 482 R L 0.984 Pathogenic MSH2 P43246 R482M 482 R M 0.798 Pathogenic MSH2 P43246 R482N 482 R N 0.178 Neutral MSH2 P43246 R482P 482 R P 0.984 Pathogenic MSH2 P43246 R482Q 482 R Q 0.102 Neutral MSH2 P43246 R482S 482 R S 0.168 Neutral MSH2 P43246 R482T 482 R T 0.906 Pathogenic MSH2 P43246 R482V 482 R V 0.972 Pathogenic MSH2 P43246 R482W 482 R W 0.968 Pathogenic MSH2 P43246 R482Y 482 R Y 0.53 Pathogenic MSH2 P43246 E483A 483 E A 0.232 Neutral MSH2 P43246 E483C 483 E C 0.354 Neutral MSH2 P43246 E483D 483 E D 0.018 Neutral MSH2 P43246 E483F 483 E F 0.836 Pathogenic MSH2 P43246 E483G 483 E G 0.1 Neutral MSH2 P43246 E483H 483 E H 0.592 Pathogenic MSH2 P43246 E483I 483 E I 0.858 Pathogenic MSH2 P43246 E483K 483 E K 0.04 Neutral MSH2 P43246 E483L 483 E L 0.472 Neutral MSH2 P43246 E483M 483 E M 0.666 Pathogenic MSH2 P43246 E483N 483 E N 0.016 Neutral MSH2 P43246 E483P 483 E P 0.862 Pathogenic MSH2 P43246 E483Q 483 E Q 0.014 Neutral MSH2 P43246 E483R 483 E R 0.134 Neutral MSH2 P43246 E483S 483 E S 0.048 Neutral MSH2 P43246 E483T 483 E T 0.052 Neutral MSH2 P43246 E483V 483 E V 0.74 Pathogenic MSH2 P43246 E483W 483 E W 0.968 Pathogenic MSH2 P43246 E483Y 483 E Y 0.906 Pathogenic MSH2 P43246 I484A 484 I A 0.072 Neutral MSH2 P43246 I484C 484 I C 0.384 Neutral MSH2 P43246 I484D 484 I D 0.104 Neutral MSH2 P43246 I484E 484 I E 0.094 Neutral MSH2 P43246 I484F 484 I F 0.684 Pathogenic MSH2 P43246 I484G 484 I G 0.2 Neutral MSH2 P43246 I484H 484 I H 0.3 Neutral MSH2 P43246 I484K 484 I K 0.19 Neutral MSH2 P43246 I484L 484 I L 0.468 Neutral MSH2 P43246 I484M 484 I M 0.44 Neutral MSH2 P43246 I484N 484 I N 0.17 Neutral MSH2 P43246 I484P 484 I P 0.7 Pathogenic MSH2 P43246 I484Q 484 I Q 0.152 Neutral MSH2 P43246 I484R 484 I R 0.55 Pathogenic MSH2 P43246 I484S 484 I S 0.114 Neutral MSH2 P43246 I484T 484 I T 0.036 Neutral MSH2 P43246 I484V 484 I V 0.018 Neutral MSH2 P43246 I484W 484 I W 0.898 Pathogenic MSH2 P43246 I484Y 484 I Y 0.904 Pathogenic MSH2 P43246 M485A 485 M A 0.556 Pathogenic MSH2 P43246 M485C 485 M C 0.476 Neutral MSH2 P43246 M485D 485 M D 0.88 Pathogenic MSH2 P43246 M485E 485 M E 0.73 Pathogenic MSH2 P43246 M485F 485 M F 0.864 Pathogenic MSH2 P43246 M485G 485 M G 0.528 Pathogenic MSH2 P43246 M485H 485 M H 0.81 Pathogenic MSH2 P43246 M485I 485 M I 0.24 Neutral MSH2 P43246 M485K 485 M K 0.234 Neutral MSH2 P43246 M485L 485 M L 0.164 Neutral MSH2 P43246 M485N 485 M N 0.918 Pathogenic MSH2 P43246 M485P 485 M P 0.928 Pathogenic MSH2 P43246 M485Q 485 M Q 0.1 Neutral MSH2 P43246 M485R 485 M R 0.246 Neutral MSH2 P43246 M485S 485 M S 0.39 Neutral MSH2 P43246 M485T 485 M T 0.36 Neutral MSH2 P43246 M485V 485 M V 0.654 Pathogenic MSH2 P43246 M485W 485 M W 0.994 Pathogenic MSH2 P43246 M485Y 485 M Y 0.968 Pathogenic MSH2 P43246 N486A 486 N A 0.184 Neutral MSH2 P43246 N486C 486 N C 0.234 Neutral MSH2 P43246 N486D 486 N D 0.01 Neutral MSH2 P43246 N486E 486 N E 0.052 Neutral MSH2 P43246 N486F 486 N F 0.582 Pathogenic MSH2 P43246 N486G 486 N G 0.226 Neutral MSH2 P43246 N486H 486 N H 0.362 Neutral MSH2 P43246 N486I 486 N I 0.436 Neutral MSH2 P43246 N486K 486 N K 0.362 Neutral MSH2 P43246 N486L 486 N L 0.246 Neutral MSH2 P43246 N486M 486 N M 0.366 Neutral MSH2 P43246 N486P 486 N P 0.394 Neutral MSH2 P43246 N486Q 486 N Q 0.246 Neutral MSH2 P43246 N486R 486 N R 0.318 Neutral MSH2 P43246 N486S 486 N S 0.004 Neutral MSH2 P43246 N486T 486 N T 0.008 Neutral MSH2 P43246 N486V 486 N V 0.45 Neutral MSH2 P43246 N486W 486 N W 0.714 Pathogenic MSH2 P43246 N486Y 486 N Y 0.668 Pathogenic MSH2 P43246 D487A 487 D A 0.014 Neutral MSH2 P43246 D487C 487 D C 0.156 Neutral MSH2 P43246 D487E 487 D E 0.01 Neutral MSH2 P43246 D487F 487 D F 0.416 Neutral MSH2 P43246 D487G 487 D G 0.018 Neutral MSH2 P43246 D487H 487 D H 0.164 Neutral MSH2 P43246 D487I 487 D I 0.332 Neutral MSH2 P43246 D487K 487 D K 0.02 Neutral MSH2 P43246 D487L 487 D L 0.28 Neutral MSH2 P43246 D487M 487 D M 0.206 Neutral MSH2 P43246 D487N 487 D N 0 Neutral MSH2 P43246 D487P 487 D P 0.302 Neutral MSH2 P43246 D487Q 487 D Q 0.014 Neutral MSH2 P43246 D487R 487 D R 0.17 Neutral MSH2 P43246 D487S 487 D S 0.002 Neutral MSH2 P43246 D487T 487 D T 0.12 Neutral MSH2 P43246 D487V 487 D V 0.264 Neutral MSH2 P43246 D487W 487 D W 0.494 Neutral MSH2 P43246 D487Y 487 D Y 0.498 Neutral MSH2 P43246 L488A 488 L A 0.14 Neutral MSH2 P43246 L488C 488 L C 0.098 Neutral MSH2 P43246 L488D 488 L D 0.252 Neutral MSH2 P43246 L488E 488 L E 0.228 Neutral MSH2 P43246 L488F 488 L F 0.448 Neutral MSH2 P43246 L488G 488 L G 0.27 Neutral MSH2 P43246 L488H 488 L H 0.132 Neutral MSH2 P43246 L488I 488 L I 0.002 Neutral MSH2 P43246 L488K 488 L K 0.174 Neutral MSH2 P43246 L488M 488 L M 0.038 Neutral MSH2 P43246 L488N 488 L N 0.268 Neutral MSH2 P43246 L488P 488 L P 0.344 Neutral MSH2 P43246 L488Q 488 L Q 0.11 Neutral MSH2 P43246 L488R 488 L R 0.54 Pathogenic MSH2 P43246 L488S 488 L S 0.306 Neutral MSH2 P43246 L488T 488 L T 0.134 Neutral MSH2 P43246 L488V 488 L V 0 Neutral MSH2 P43246 L488W 488 L W 0.572 Pathogenic MSH2 P43246 L488Y 488 L Y 0.532 Pathogenic MSH2 P43246 E489A 489 E A 0.222 Neutral MSH2 P43246 E489C 489 E C 0.152 Neutral MSH2 P43246 E489D 489 E D 0.01 Neutral MSH2 P43246 E489F 489 E F 0.49 Neutral MSH2 P43246 E489G 489 E G 0.178 Neutral MSH2 P43246 E489H 489 E H 0.25 Neutral MSH2 P43246 E489I 489 E I 0.582 Pathogenic MSH2 P43246 E489K 489 E K 0.398 Neutral MSH2 P43246 E489L 489 E L 0.082 Neutral MSH2 P43246 E489M 489 E M 0.358 Neutral MSH2 P43246 E489N 489 E N 0.124 Neutral MSH2 P43246 E489P 489 E P 0.542 Pathogenic MSH2 P43246 E489Q 489 E Q 0.082 Neutral MSH2 P43246 E489R 489 E R 0.148 Neutral MSH2 P43246 E489S 489 E S 0.12 Neutral MSH2 P43246 E489T 489 E T 0.292 Neutral MSH2 P43246 E489V 489 E V 0.474 Neutral MSH2 P43246 E489W 489 E W 0.772 Pathogenic MSH2 P43246 E489Y 489 E Y 0.298 Neutral MSH2 P43246 D49A 49 D A 0.34 Neutral MSH2 P43246 D49C 49 D C 0.91 Pathogenic MSH2 P43246 D49E 49 D E 0.264 Neutral MSH2 P43246 D49F 49 D F 0.984 Pathogenic MSH2 P43246 D49G 49 D G 0.892 Pathogenic MSH2 P43246 D49H 49 D H 0.62 Pathogenic MSH2 P43246 D49I 49 D I 0.81 Pathogenic MSH2 P43246 D49K 49 D K 0.974 Pathogenic MSH2 P43246 D49L 49 D L 0.768 Pathogenic MSH2 P43246 D49M 49 D M 0.944 Pathogenic MSH2 P43246 D49N 49 D N 0.074 Neutral MSH2 P43246 D49P 49 D P 0.458 Neutral MSH2 P43246 D49Q 49 D Q 0.44 Neutral MSH2 P43246 D49R 49 D R 0.894 Pathogenic MSH2 P43246 D49S 49 D S 0.114 Neutral MSH2 P43246 D49T 49 D T 0.464 Neutral MSH2 P43246 D49V 49 D V 0.772 Pathogenic MSH2 P43246 D49W 49 D W 0.986 Pathogenic MSH2 P43246 D49Y 49 D Y 0.98 Pathogenic MSH2 P43246 K490A 490 K A 0.074 Neutral MSH2 P43246 K490C 490 K C 0.086 Neutral MSH2 P43246 K490D 490 K D 0.014 Neutral MSH2 P43246 K490E 490 K E 0.014 Neutral MSH2 P43246 K490F 490 K F 0.778 Pathogenic MSH2 P43246 K490G 490 K G 0.302 Neutral MSH2 P43246 K490H 490 K H 0.15 Neutral MSH2 P43246 K490I 490 K I 0.148 Neutral MSH2 P43246 K490L 490 K L 0.676 Pathogenic MSH2 P43246 K490M 490 K M 0.13 Neutral MSH2 P43246 K490N 490 K N 0.052 Neutral MSH2 P43246 K490P 490 K P 0.832 Pathogenic MSH2 P43246 K490Q 490 K Q 0.05 Neutral MSH2 P43246 K490R 490 K R 0.052 Neutral MSH2 P43246 K490S 490 K S 0.026 Neutral MSH2 P43246 K490T 490 K T 0.156 Neutral MSH2 P43246 K490V 490 K V 0.208 Neutral MSH2 P43246 K490W 490 K W 0.98 Pathogenic MSH2 P43246 K490Y 490 K Y 0.932 Pathogenic MSH2 P43246 K491A 491 K A 0.088 Neutral MSH2 P43246 K491C 491 K C 0.172 Neutral MSH2 P43246 K491D 491 K D 0.026 Neutral MSH2 P43246 K491E 491 K E 0.028 Neutral MSH2 P43246 K491F 491 K F 0.802 Pathogenic MSH2 P43246 K491G 491 K G 0.252 Neutral MSH2 P43246 K491H 491 K H 0.334 Neutral MSH2 P43246 K491I 491 K I 0.756 Pathogenic MSH2 P43246 K491L 491 K L 0.424 Neutral MSH2 P43246 K491M 491 K M 0.592 Pathogenic MSH2 P43246 K491N 491 K N 0.04 Neutral MSH2 P43246 K491P 491 K P 0.796 Pathogenic MSH2 P43246 K491Q 491 K Q 0.04 Neutral MSH2 P43246 K491R 491 K R 0.04 Neutral MSH2 P43246 K491S 491 K S 0.034 Neutral MSH2 P43246 K491T 491 K T 0.044 Neutral MSH2 P43246 K491V 491 K V 0.122 Neutral MSH2 P43246 K491W 491 K W 0.976 Pathogenic MSH2 P43246 K491Y 491 K Y 0.92 Pathogenic MSH2 P43246 M492A 492 M A 0.122 Neutral MSH2 P43246 M492C 492 M C 0.074 Neutral MSH2 P43246 M492D 492 M D 0.662 Pathogenic MSH2 P43246 M492E 492 M E 0.444 Neutral MSH2 P43246 M492F 492 M F 0.706 Pathogenic MSH2 P43246 M492G 492 M G 0.348 Neutral MSH2 P43246 M492H 492 M H 0.518 Pathogenic MSH2 P43246 M492I 492 M I 0.058 Neutral MSH2 P43246 M492K 492 M K 0.686 Pathogenic MSH2 P43246 M492L 492 M L 0.05 Neutral MSH2 P43246 M492N 492 M N 0.15 Neutral MSH2 P43246 M492P 492 M P 0.848 Pathogenic MSH2 P43246 M492Q 492 M Q 0.376 Neutral MSH2 P43246 M492R 492 M R 0.71 Pathogenic MSH2 P43246 M492S 492 M S 0.056 Neutral MSH2 P43246 M492T 492 M T 0.018 Neutral MSH2 P43246 M492V 492 M V 0.046 Neutral MSH2 P43246 M492W 492 M W 0.93 Pathogenic MSH2 P43246 M492Y 492 M Y 0.86 Pathogenic MSH2 P43246 Q493A 493 Q A 0.536 Pathogenic MSH2 P43246 Q493C 493 Q C 0.49 Neutral MSH2 P43246 Q493D 493 Q D 0.038 Neutral MSH2 P43246 Q493E 493 Q E 0.018 Neutral MSH2 P43246 Q493F 493 Q F 0.84 Pathogenic MSH2 P43246 Q493G 493 Q G 0.386 Neutral MSH2 P43246 Q493H 493 Q H 0.808 Pathogenic MSH2 P43246 Q493I 493 Q I 0.896 Pathogenic MSH2 P43246 Q493K 493 Q K 0.042 Neutral MSH2 P43246 Q493L 493 Q L 0.448 Neutral MSH2 P43246 Q493M 493 Q M 0.692 Pathogenic MSH2 P43246 Q493N 493 Q N 0.09 Neutral MSH2 P43246 Q493P 493 Q P 0.798 Pathogenic MSH2 P43246 Q493R 493 Q R 0.074 Neutral MSH2 P43246 Q493S 493 Q S 0.156 Neutral MSH2 P43246 Q493T 493 Q T 0.086 Neutral MSH2 P43246 Q493V 493 Q V 0.71 Pathogenic MSH2 P43246 Q493W 493 Q W 0.926 Pathogenic MSH2 P43246 Q493Y 493 Q Y 0.888 Pathogenic MSH2 P43246 S494A 494 S A 0.032 Neutral MSH2 P43246 S494C 494 S C 0.304 Neutral MSH2 P43246 S494D 494 S D 0.044 Neutral MSH2 P43246 S494E 494 S E 0.366 Neutral MSH2 P43246 S494F 494 S F 0.756 Pathogenic MSH2 P43246 S494G 494 S G 0.044 Neutral MSH2 P43246 S494H 494 S H 0.404 Neutral MSH2 P43246 S494I 494 S I 0.448 Neutral MSH2 P43246 S494K 494 S K 0.376 Neutral MSH2 P43246 S494L 494 S L 0.166 Neutral MSH2 P43246 S494M 494 S M 0.886 Pathogenic MSH2 P43246 S494N 494 S N 0.04 Neutral MSH2 P43246 S494P 494 S P 0.462 Neutral MSH2 P43246 S494Q 494 S Q 0.402 Neutral MSH2 P43246 S494R 494 S R 0.386 Neutral MSH2 P43246 S494T 494 S T 0.054 Neutral MSH2 P43246 S494V 494 S V 0.2 Neutral MSH2 P43246 S494W 494 S W 0.904 Pathogenic MSH2 P43246 S494Y 494 S Y 0.604 Pathogenic MSH2 P43246 T495A 495 T A 0.008 Neutral MSH2 P43246 T495C 495 T C 0.144 Neutral MSH2 P43246 T495D 495 T D 0.038 Neutral MSH2 P43246 T495E 495 T E 0.048 Neutral MSH2 P43246 T495F 495 T F 0.532 Pathogenic MSH2 P43246 T495G 495 T G 0.01 Neutral MSH2 P43246 T495H 495 T H 0.106 Neutral MSH2 P43246 T495I 495 T I 0.176 Neutral MSH2 P43246 T495K 495 T K 0.02 Neutral MSH2 P43246 T495L 495 T L 0.024 Neutral MSH2 P43246 T495M 495 T M 0.382 Neutral MSH2 P43246 T495N 495 T N 0.018 Neutral MSH2 P43246 T495P 495 T P 0.346 Neutral MSH2 P43246 T495Q 495 T Q 0.012 Neutral MSH2 P43246 T495R 495 T R 0.476 Neutral MSH2 P43246 T495S 495 T S 0.002 Neutral MSH2 P43246 T495V 495 T V 0.032 Neutral MSH2 P43246 T495W 495 T W 0.838 Pathogenic MSH2 P43246 T495Y 495 T Y 0.804 Pathogenic MSH2 P43246 L496A 496 L A 0.12 Neutral MSH2 P43246 L496C 496 L C 0.686 Pathogenic MSH2 P43246 L496D 496 L D 0.916 Pathogenic MSH2 P43246 L496E 496 L E 0.896 Pathogenic MSH2 P43246 L496F 496 L F 0.48 Neutral MSH2 P43246 L496G 496 L G 0.814 Pathogenic MSH2 P43246 L496H 496 L H 0.786 Pathogenic MSH2 P43246 L496I 496 L I 0.138 Neutral MSH2 P43246 L496K 496 L K 0.184 Neutral MSH2 P43246 L496M 496 L M 0.186 Neutral MSH2 P43246 L496N 496 L N 0.788 Pathogenic MSH2 P43246 L496P 496 L P 0.986 Pathogenic MSH2 P43246 L496Q 496 L Q 0.136 Neutral MSH2 P43246 L496R 496 L R 0.572 Pathogenic MSH2 P43246 L496S 496 L S 0.608 Pathogenic MSH2 P43246 L496T 496 L T 0.582 Pathogenic MSH2 P43246 L496V 496 L V 0.312 Neutral MSH2 P43246 L496W 496 L W 0.91 Pathogenic MSH2 P43246 L496Y 496 L Y 0.82 Pathogenic MSH2 P43246 I497A 497 I A 0.072 Neutral MSH2 P43246 I497C 497 I C 0.38 Neutral MSH2 P43246 I497D 497 I D 0.108 Neutral MSH2 P43246 I497E 497 I E 0.106 Neutral MSH2 P43246 I497F 497 I F 0.364 Neutral MSH2 P43246 I497G 497 I G 0.186 Neutral MSH2 P43246 I497H 497 I H 0.056 Neutral MSH2 P43246 I497K 497 I K 0.098 Neutral MSH2 P43246 I497L 497 I L 0.54 Pathogenic MSH2 P43246 I497M 497 I M 0.512 Pathogenic MSH2 P43246 I497N 497 I N 0.17 Neutral MSH2 P43246 I497P 497 I P 0.65 Pathogenic MSH2 P43246 I497Q 497 I Q 0.174 Neutral MSH2 P43246 I497R 497 I R 0.508 Pathogenic MSH2 P43246 I497S 497 I S 0.126 Neutral MSH2 P43246 I497T 497 I T 0.056 Neutral MSH2 P43246 I497V 497 I V 0.042 Neutral MSH2 P43246 I497W 497 I W 0.812 Pathogenic MSH2 P43246 I497Y 497 I Y 0.694 Pathogenic MSH2 P43246 S498A 498 S A 0.024 Neutral MSH2 P43246 S498C 498 S C 0.308 Neutral MSH2 P43246 S498D 498 S D 0.026 Neutral MSH2 P43246 S498E 498 S E 0.358 Neutral MSH2 P43246 S498F 498 S F 0.742 Pathogenic MSH2 P43246 S498G 498 S G 0.03 Neutral MSH2 P43246 S498H 498 S H 0.496 Neutral MSH2 P43246 S498I 498 S I 0.308 Neutral MSH2 P43246 S498K 498 S K 0.372 Neutral MSH2 P43246 S498L 498 S L 0.148 Neutral MSH2 P43246 S498M 498 S M 0.834 Pathogenic MSH2 P43246 S498N 498 S N 0.024 Neutral MSH2 P43246 S498P 498 S P 0.444 Neutral MSH2 P43246 S498Q 498 S Q 0.396 Neutral MSH2 P43246 S498R 498 S R 0.378 Neutral MSH2 P43246 S498T 498 S T 0.038 Neutral MSH2 P43246 S498V 498 S V 0.072 Neutral MSH2 P43246 S498W 498 S W 0.896 Pathogenic MSH2 P43246 S498Y 498 S Y 0.868 Pathogenic MSH2 P43246 A499C 499 A C 0.19 Neutral MSH2 P43246 A499D 499 A D 0.806 Pathogenic MSH2 P43246 A499E 499 A E 0.598 Pathogenic MSH2 P43246 A499F 499 A F 0.7 Pathogenic MSH2 P43246 A499G 499 A G 0.456 Neutral MSH2 P43246 A499H 499 A H 0.822 Pathogenic MSH2 P43246 A499I 499 A I 0.642 Pathogenic MSH2 P43246 A499K 499 A K 0.866 Pathogenic MSH2 P43246 A499L 499 A L 0.59 Pathogenic MSH2 P43246 A499M 499 A M 0.784 Pathogenic MSH2 P43246 A499N 499 A N 0.736 Pathogenic MSH2 P43246 A499P 499 A P 0.87 Pathogenic MSH2 P43246 A499Q 499 A Q 0.512 Pathogenic MSH2 P43246 A499R 499 A R 0.876 Pathogenic MSH2 P43246 A499S 499 A S 0.372 Neutral MSH2 P43246 A499T 499 A T 0.054 Neutral MSH2 P43246 A499V 499 A V 0.178 Neutral MSH2 P43246 A499W 499 A W 0.924 Pathogenic MSH2 P43246 A499Y 499 A Y 0.908 Pathogenic MSH2 P43246 P5A 5 P A 0.182 Neutral MSH2 P43246 P5C 5 P C 0.164 Neutral MSH2 P43246 P5D 5 P D 0.054 Neutral MSH2 P43246 P5E 5 P E 0.262 Neutral MSH2 P43246 P5F 5 P F 0.312 Neutral MSH2 P43246 P5G 5 P G 0.092 Neutral MSH2 P43246 P5H 5 P H 0.34 Neutral MSH2 P43246 P5I 5 P I 0.124 Neutral MSH2 P43246 P5K 5 P K 0.126 Neutral MSH2 P43246 P5L 5 P L 0.124 Neutral MSH2 P43246 P5M 5 P M 0.274 Neutral MSH2 P43246 P5N 5 P N 0.068 Neutral MSH2 P43246 P5Q 5 P Q 0.12 Neutral MSH2 P43246 P5R 5 P R 0.246 Neutral MSH2 P43246 P5S 5 P S 0.022 Neutral MSH2 P43246 P5T 5 P T 0.192 Neutral MSH2 P43246 P5V 5 P V 0.152 Neutral MSH2 P43246 P5W 5 P W 0.462 Neutral MSH2 P43246 P5Y 5 P Y 0.39 Neutral MSH2 P43246 A50C 50 A C 0.894 Pathogenic MSH2 P43246 A50D 50 A D 0.612 Pathogenic MSH2 P43246 A50E 50 A E 0.902 Pathogenic MSH2 P43246 A50F 50 A F 0.966 Pathogenic MSH2 P43246 A50G 50 A G 0.312 Neutral MSH2 P43246 A50H 50 A H 0.886 Pathogenic MSH2 P43246 A50I 50 A I 0.956 Pathogenic MSH2 P43246 A50K 50 A K 0.94 Pathogenic MSH2 P43246 A50L 50 A L 0.98 Pathogenic MSH2 P43246 A50M 50 A M 0.864 Pathogenic MSH2 P43246 A50N 50 A N 0.846 Pathogenic MSH2 P43246 A50P 50 A P 0.968 Pathogenic MSH2 P43246 A50Q 50 A Q 0.834 Pathogenic MSH2 P43246 A50R 50 A R 0.754 Pathogenic MSH2 P43246 A50S 50 A S 0.226 Neutral MSH2 P43246 A50T 50 A T 0.758 Pathogenic MSH2 P43246 A50V 50 A V 0.914 Pathogenic MSH2 P43246 A50W 50 A W 0.976 Pathogenic MSH2 P43246 A50Y 50 A Y 0.96 Pathogenic MSH2 P43246 A500C 500 A C 0.522 Pathogenic MSH2 P43246 A500D 500 A D 0.928 Pathogenic MSH2 P43246 A500E 500 A E 0.956 Pathogenic MSH2 P43246 A500F 500 A F 0.658 Pathogenic MSH2 P43246 A500G 500 A G 0.358 Neutral MSH2 P43246 A500H 500 A H 0.64 Pathogenic MSH2 P43246 A500I 500 A I 0.918 Pathogenic MSH2 P43246 A500K 500 A K 0.95 Pathogenic MSH2 P43246 A500L 500 A L 0.798 Pathogenic MSH2 P43246 A500M 500 A M 0.878 Pathogenic MSH2 P43246 A500N 500 A N 0.536 Pathogenic MSH2 P43246 A500P 500 A P 0.956 Pathogenic MSH2 P43246 A500Q 500 A Q 0.654 Pathogenic MSH2 P43246 A500R 500 A R 0.626 Pathogenic MSH2 P43246 A500S 500 A S 0.138 Neutral MSH2 P43246 A500T 500 A T 0.44 Neutral MSH2 P43246 A500V 500 A V 0.872 Pathogenic MSH2 P43246 A500W 500 A W 0.982 Pathogenic MSH2 P43246 A500Y 500 A Y 0.754 Pathogenic MSH2 P43246 R501A 501 R A 0.11 Neutral MSH2 P43246 R501C 501 R C 0.652 Pathogenic MSH2 P43246 R501D 501 R D 0.048 Neutral MSH2 P43246 R501E 501 R E 0.066 Neutral MSH2 P43246 R501F 501 R F 0.91 Pathogenic MSH2 P43246 R501G 501 R G 0.196 Neutral MSH2 P43246 R501H 501 R H 0.046 Neutral MSH2 P43246 R501I 501 R I 0.3 Neutral MSH2 P43246 R501K 501 R K 0.034 Neutral MSH2 P43246 R501L 501 R L 0.122 Neutral MSH2 P43246 R501M 501 R M 0.16 Neutral MSH2 P43246 R501N 501 R N 0.03 Neutral MSH2 P43246 R501P 501 R P 0.824 Pathogenic MSH2 P43246 R501Q 501 R Q 0.016 Neutral MSH2 P43246 R501S 501 R S 0.058 Neutral MSH2 P43246 R501T 501 R T 0.064 Neutral MSH2 P43246 R501V 501 R V 0.402 Neutral MSH2 P43246 R501W 501 R W 0.896 Pathogenic MSH2 P43246 R501Y 501 R Y 0.87 Pathogenic MSH2 P43246 D502A 502 D A 0.106 Neutral MSH2 P43246 D502C 502 D C 0.728 Pathogenic MSH2 P43246 D502E 502 D E 0.04 Neutral MSH2 P43246 D502F 502 D F 0.884 Pathogenic MSH2 P43246 D502G 502 D G 0.092 Neutral MSH2 P43246 D502H 502 D H 0.174 Neutral MSH2 P43246 D502I 502 D I 0.532 Pathogenic MSH2 P43246 D502K 502 D K 0.066 Neutral MSH2 P43246 D502L 502 D L 0.142 Neutral MSH2 P43246 D502M 502 D M 0.79 Pathogenic MSH2 P43246 D502N 502 D N 0.028 Neutral MSH2 P43246 D502P 502 D P 0.8 Pathogenic MSH2 P43246 D502Q 502 D Q 0.016 Neutral MSH2 P43246 D502R 502 D R 0.472 Neutral MSH2 P43246 D502S 502 D S 0.062 Neutral MSH2 P43246 D502T 502 D T 0.552 Pathogenic MSH2 P43246 D502V 502 D V 0.186 Neutral MSH2 P43246 D502W 502 D W 0.97 Pathogenic MSH2 P43246 D502Y 502 D Y 0.964 Pathogenic MSH2 P43246 L503A 503 L A 0.106 Neutral MSH2 P43246 L503C 503 L C 0.65 Pathogenic MSH2 P43246 L503D 503 L D 0.922 Pathogenic MSH2 P43246 L503E 503 L E 0.884 Pathogenic MSH2 P43246 L503F 503 L F 0.722 Pathogenic MSH2 P43246 L503G 503 L G 0.816 Pathogenic MSH2 P43246 L503H 503 L H 0.718 Pathogenic MSH2 P43246 L503I 503 L I 0.142 Neutral MSH2 P43246 L503K 503 L K 0.656 Pathogenic MSH2 P43246 L503M 503 L M 0.63 Pathogenic MSH2 P43246 L503N 503 L N 0.8 Pathogenic MSH2 P43246 L503P 503 L P 0.944 Pathogenic MSH2 P43246 L503Q 503 L Q 0.572 Pathogenic MSH2 P43246 L503R 503 L R 0.986 Pathogenic MSH2 P43246 L503S 503 L S 0.134 Neutral MSH2 P43246 L503T 503 L T 0.108 Neutral MSH2 P43246 L503V 503 L V 0.1 Neutral MSH2 P43246 L503W 503 L W 0.81 Pathogenic MSH2 P43246 L503Y 503 L Y 0.768 Pathogenic MSH2 P43246 G504A 504 G A 0.058 Neutral MSH2 P43246 G504C 504 G C 0.158 Neutral MSH2 P43246 G504D 504 G D 0.126 Neutral MSH2 P43246 G504E 504 G E 0.354 Neutral MSH2 P43246 G504F 504 G F 0.538 Pathogenic MSH2 P43246 G504H 504 G H 0.482 Neutral MSH2 P43246 G504I 504 G I 0.45 Neutral MSH2 P43246 G504K 504 G K 0.294 Neutral MSH2 P43246 G504L 504 G L 0.45 Neutral MSH2 P43246 G504M 504 G M 0.468 Neutral MSH2 P43246 G504N 504 G N 0.17 Neutral MSH2 P43246 G504P 504 G P 0.42 Neutral MSH2 P43246 G504Q 504 G Q 0.206 Neutral MSH2 P43246 G504R 504 G R 0.518 Pathogenic 4 MSH2 P43246 G504S 504 G S 0.02 Neutral MSH2 P43246 G504T 504 G T 0.302 Neutral MSH2 P43246 G504V 504 G V 0.438 Neutral MSH2 P43246 G504W 504 G W 0.538 Pathogenic MSH2 P43246 G504Y 504 G Y 0.534 Pathogenic MSH2 P43246 L505A 505 L A 0.712 Pathogenic MSH2 P43246 L505C 505 L C 0.822 Pathogenic MSH2 P43246 L505D 505 L D 0.91 Pathogenic MSH2 P43246 L505E 505 L E 0.894 Pathogenic MSH2 P43246 L505F 505 L F 0.794 Pathogenic MSH2 P43246 L505G 505 L G 0.862 Pathogenic MSH2 P43246 L505H 505 L H 0.908 Pathogenic MSH2 P43246 L505I 505 L I 0.442 Neutral MSH2 P43246 L505K 505 L K 0.716 Pathogenic MSH2 P43246 L505M 505 L M 0.348 Neutral MSH2 P43246 L505N 505 L N 0.82 Pathogenic MSH2 P43246 L505P 505 L P 0.994 Pathogenic MSH2 P43246 L505Q 505 L Q 0.774 Pathogenic MSH2 P43246 L505R 505 L R 0.984 Pathogenic MSH2 P43246 L505S 505 L S 0.474 Neutral MSH2 P43246 L505T 505 L T 0.444 Neutral MSH2 P43246 L505V 505 L V 0.34 Neutral MSH2 P43246 L505W 505 L W 0.878 Pathogenic MSH2 P43246 L505Y 505 L Y 0.886 Pathogenic MSH2 P43246 D506A 506 D A 0.518 Pathogenic MSH2 P43246 D506C 506 D C 0.324 Neutral MSH2 P43246 D506E 506 D E 0.04 Neutral MSH2 P43246 D506F 506 D F 0.914 Pathogenic MSH2 P43246 D506G 506 D G 0.054 Neutral MSH2 P43246 D506H 506 D H 0.276 Neutral MSH2 P43246 D506I 506 D I 0.874 Pathogenic MSH2 P43246 D506K 506 D K 0.112 Neutral MSH2 P43246 D506L 506 D L 0.864 Pathogenic MSH2 P43246 D506M 506 D M 0.778 Pathogenic MSH2 P43246 D506N 506 D N 0.012 Neutral MSH2 P43246 D506P 506 D P 0.762 Pathogenic MSH2 P43246 D506Q 506 D Q 0.454 Neutral MSH2 P43246 D506R 506 D R 0.49 Neutral MSH2 P43246 D506S 506 D S 0.012 Neutral MSH2 P43246 D506T 506 D T 0.528 Pathogenic MSH2 P43246 D506V 506 D V 0.894 Pathogenic MSH2 P43246 D506W 506 D W 0.944 Pathogenic MSH2 P43246 D506Y 506 D Y 0.932 Pathogenic MSH2 P43246 P507A 507 P A 0.098 Neutral MSH2 P43246 P507C 507 P C 0.514 Pathogenic MSH2 P43246 P507D 507 P D 0.392 Neutral MSH2 P43246 P507E 507 P E 0.598 Pathogenic MSH2 P43246 P507F 507 P F 0.63 Pathogenic MSH2 P43246 P507G 507 P G 0.096 Neutral MSH2 P43246 P507H 507 P H 0.84 Pathogenic MSH2 P43246 P507I 507 P I 0.172 Neutral MSH2 P43246 P507K 507 P K 0.146 Neutral MSH2 P43246 P507L 507 P L 0.132 Neutral MSH2 P43246 P507M 507 P M 0.226 Neutral MSH2 P43246 P507N 507 P N 0.3 Neutral MSH2 P43246 P507Q 507 P Q 0.162 Neutral MSH2 P43246 P507R 507 P R 0.858 Pathogenic MSH2 P43246 P507S 507 P S 0.1 Neutral MSH2 P43246 P507T 507 P T 0.12 Neutral MSH2 P43246 P507V 507 P V 0.18 Neutral MSH2 P43246 P507W 507 P W 0.92 Pathogenic MSH2 P43246 P507Y 507 P Y 0.908 Pathogenic MSH2 P43246 G508A 508 G A 0.074 Neutral MSH2 P43246 G508C 508 G C 0.808 Pathogenic MSH2 P43246 G508D 508 G D 0.47 Neutral MSH2 P43246 G508E 508 G E 0.562 Pathogenic MSH2 P43246 G508F 508 G F 0.974 Pathogenic MSH2 P43246 G508H 508 G H 0.968 Pathogenic MSH2 P43246 G508I 508 G I 0.936 Pathogenic MSH2 P43246 G508K 508 G K 0.656 Pathogenic MSH2 P43246 G508L 508 G L 0.97 Pathogenic MSH2 P43246 G508M 508 G M 0.984 Pathogenic MSH2 P43246 G508N 508 G N 0.49 Neutral MSH2 P43246 G508P 508 G P 0.626 Pathogenic MSH2 P43246 G508Q 508 G Q 0.636 Pathogenic MSH2 P43246 G508R 508 G R 0.986 Pathogenic MSH2 P43246 G508S 508 G S 0.11 Neutral MSH2 P43246 G508T 508 G T 0.826 Pathogenic MSH2 P43246 G508V 508 G V 0.976 Pathogenic MSH2 P43246 G508W 508 G W 0.96 Pathogenic MSH2 P43246 G508Y 508 G Y 0.952 Pathogenic MSH2 P43246 K509A 509 K A 0.09 Neutral MSH2 P43246 K509C 509 K C 0.172 Neutral MSH2 P43246 K509D 509 K D 0.24 Neutral MSH2 P43246 K509E 509 K E 0.032 Neutral MSH2 P43246 K509F 509 K F 0.776 Pathogenic MSH2 P43246 K509G 509 K G 0.364 Neutral MSH2 P43246 K509H 509 K H 0.28 Neutral MSH2 P43246 K509I 509 K I 0.124 Neutral MSH2 P43246 K509L 509 K L 0.104 Neutral MSH2 P43246 K509M 509 K M 0.04 Neutral MSH2 P43246 K509N 509 K N 0.182 Neutral MSH2 P43246 K509P 509 K P 0.098 Neutral MSH2 P43246 K509Q 509 K Q 0.158 Neutral MSH2 P43246 K509R 509 K R 0.03 Neutral MSH2 P43246 K509S 509 K S 0.078 Neutral MSH2 P43246 K509T 509 K T 0.032 Neutral MSH2 P43246 K509V 509 K V 0.106 Neutral MSH2 P43246 K509W 509 K W 0.954 Pathogenic MSH2 P43246 K509Y 509 K Y 0.88 Pathogenic MSH2 P43246 L51A 51 L A 0.012 Neutral MSH2 P43246 L51C 51 L C 0.01 Neutral MSH2 P43246 L51D 51 L D 0.05 Neutral MSH2 P43246 L51E 51 L E 0.04 Neutral MSH2 P43246 L51F 51 L F 0.31 Neutral MSH2 P43246 L51G 51 L G 0.268 Neutral MSH2 P43246 L51H 51 L H 0.01 Neutral MSH2 P43246 L51I 51 L I 0.004 Neutral MSH2 P43246 L51K 51 L K 0.028 Neutral MSH2 P43246 L51M 51 L M 0.012 Neutral MSH2 P43246 L51N 51 L N 0.038 Neutral MSH2 P43246 L51P 51 L P 0.342 Neutral MSH2 P43246 L51Q 51 L Q 0.01 Neutral MSH2 P43246 L51R 51 L R 0.472 Neutral MSH2 P43246 L51S 51 L S 0.016 Neutral MSH2 P43246 L51T 51 L T 0.018 Neutral MSH2 P43246 L51V 51 L V 0 Neutral MSH2 P43246 L51W 51 L W 0.54 Pathogenic MSH2 P43246 L51Y 51 L Y 0.5 Pathogenic MSH2 P43246 Q510A 510 Q A 0.238 Neutral MSH2 P43246 Q510C 510 Q C 0.442 Neutral MSH2 P43246 Q510D 510 Q D 0.04 Neutral MSH2 P43246 Q510E 510 Q E 0.024 Neutral MSH2 P43246 Q510F 510 Q F 0.82 Pathogenic MSH2 P43246 Q510G 510 Q G 0.132 Neutral MSH2 P43246 Q510H 510 Q H 0.432 Neutral MSH2 P43246 Q510I 510 Q I 0.574 Pathogenic MSH2 P43246 Q510K 510 Q K 0.76 Pathogenic MSH2 P43246 Q510L 510 Q L 0.788 Pathogenic MSH2 P43246 Q510M 510 Q M 0.726 Pathogenic MSH2 P43246 Q510N 510 Q N 0.098 Neutral MSH2 P43246 Q510P 510 Q P 0.844 Pathogenic MSH2 P43246 Q510R 510 Q R 0.276 Neutral MSH2 P43246 Q510S 510 Q S 0.09 Neutral MSH2 P43246 Q510T 510 Q T 0.024 Neutral MSH2 P43246 Q510V 510 Q V 0.106 Neutral MSH2 P43246 Q510W 510 Q W 0.93 Pathogenic MSH2 P43246 Q510Y 510 Q Y 0.89 Pathogenic MSH2 P43246 I511A 511 I A 0.314 Neutral MSH2 P43246 I511C 511 I C 0.474 Neutral MSH2 P43246 I511D 511 I D 0.65 Pathogenic MSH2 P43246 I511E 511 I E 0.64 Pathogenic MSH2 P43246 I511F 511 I F 0.708 Pathogenic MSH2 P43246 I511G 511 I G 0.63 Pathogenic MSH2 P43246 I511H 511 I H 0.574 Pathogenic MSH2 P43246 I511K 511 I K 0.226 Neutral MSH2 P43246 I511L 511 I L 0.044 Neutral MSH2 P43246 I511M 511 I M 0.158 Neutral MSH2 P43246 I511N 511 I N 0.686 Pathogenic MSH2 P43246 I511P 511 I P 0.752 Pathogenic MSH2 P43246 I511Q 511 I Q 0.674 Pathogenic MSH2 P43246 I511R 511 I R 0.832 Pathogenic MSH2 P43246 I511S 511 I S 0.422 Neutral MSH2 P43246 I511T 511 I T 0.308 Neutral MSH2 P43246 I511V 511 I V 0.058 Neutral MSH2 P43246 I511W 511 I W 0.858 Pathogenic MSH2 P43246 I511Y 511 I Y 0.848 Pathogenic MSH2 P43246 K512A 512 K A 0.7 Pathogenic MSH2 P43246 K512C 512 K C 0.574 Pathogenic MSH2 P43246 K512D 512 K D 0.76 Pathogenic MSH2 P43246 K512E 512 K E 0.396 Neutral MSH2 P43246 K512F 512 K F 0.95 Pathogenic MSH2 P43246 K512G 512 K G 0.544 Pathogenic MSH2 P43246 K512H 512 K H 0.868 Pathogenic MSH2 P43246 K512I 512 K I 0.982 Pathogenic MSH2 P43246 K512L 512 K L 0.974 Pathogenic MSH2 P43246 K512M 512 K M 0.874 Pathogenic MSH2 P43246 K512N 512 K N 0.778 Pathogenic MSH2 P43246 K512P 512 K P 0.914 Pathogenic MSH2 P43246 K512Q 512 K Q 0.39 Neutral MSH2 P43246 K512R 512 K R 0.398 Neutral MSH2 P43246 K512S 512 K S 0.28 Neutral MSH2 P43246 K512T 512 K T 0.174 Neutral MSH2 P43246 K512V 512 K V 0.222 Neutral MSH2 P43246 K512W 512 K W 0.978 Pathogenic MSH2 P43246 K512Y 512 K Y 0.968 Pathogenic MSH2 P43246 L513A 513 L A 0.706 Pathogenic MSH2 P43246 L513C 513 L C 0.82 Pathogenic MSH2 P43246 L513D 513 L D 0.888 Pathogenic MSH2 P43246 L513E 513 L E 0.868 Pathogenic MSH2 P43246 L513F 513 L F 0.904 Pathogenic MSH2 P43246 L513G 513 L G 0.828 Pathogenic MSH2 P43246 L513H 513 L H 0.908 Pathogenic MSH2 P43246 L513I 513 L I 0.226 Neutral MSH2 P43246 L513K 513 L K 0.724 Pathogenic MSH2 P43246 L513M 513 L M 0.662 Pathogenic MSH2 P43246 L513N 513 L N 0.764 Pathogenic MSH2 P43246 L513P 513 L P 0.994 Pathogenic MSH2 P43246 L513Q 513 L Q 0.732 Pathogenic MSH2 P43246 L513R 513 L R 0.978 Pathogenic MSH2 P43246 L513S 513 L S 0.646 Pathogenic MSH2 P43246 L513T 513 L T 0.602 Pathogenic MSH2 P43246 L513V 513 L V 0.18 Neutral MSH2 P43246 L513W 513 L W 0.892 Pathogenic MSH2 P43246 L513Y 513 L Y 0.88 Pathogenic MSH2 P43246 D514A 514 D A 0.452 Neutral MSH2 P43246 D514C 514 D C 0.66 Pathogenic MSH2 P43246 D514E 514 D E 0.024 Neutral MSH2 P43246 D514F 514 D F 0.87 Pathogenic MSH2 P43246 D514G 514 D G 0.468 Neutral MSH2 P43246 D514H 514 D H 0.048 Neutral MSH2 P43246 D514I 514 D I 0.818 Pathogenic MSH2 P43246 D514K 514 D K 0.042 Neutral MSH2 P43246 D514L 514 D L 0.814 Pathogenic MSH2 P43246 D514M 514 D M 0.734 Pathogenic MSH2 P43246 D514N 514 D N 0.28 Neutral MSH2 P43246 D514P 514 D P 0.772 Pathogenic MSH2 P43246 D514Q 514 D Q 0.526 Pathogenic MSH2 P43246 D514R 514 D R 0.562 Pathogenic MSH2 P43246 D514S 514 D S 0.498 Neutral MSH2 P43246 D514T 514 D T 0.516 Pathogenic MSH2 P43246 D514V 514 D V 0.852 Pathogenic MSH2 P43246 D514W 514 D W 0.93 Pathogenic MSH2 P43246 D514Y 514 D Y 0.92 Pathogenic MSH2 P43246 S515A 515 S A 0.14 Neutral MSH2 P43246 S515C 515 S C 0.038 Neutral MSH2 P43246 S515D 515 S D 0.114 Neutral MSH2 P43246 S515E 515 S E 0.326 Neutral MSH2 P43246 S515F 515 S F 0.514 Pathogenic MSH2 P43246 S515G 515 S G 0.116 Neutral MSH2 P43246 S515H 515 S H 0.288 Neutral MSH2 P43246 S515I 515 S I 0.164 Neutral MSH2 P43246 S515K 515 S K 0.25 Neutral MSH2 P43246 S515L 515 S L 0.058 Neutral MSH2 P43246 S515M 515 S M 0.62 Pathogenic MSH2 P43246 S515N 515 S N 0.038 Neutral MSH2 P43246 S515P 515 S P 0.21 Neutral MSH2 P43246 S515Q 515 S Q 0.278 Neutral MSH2 P43246 S515R 515 S R 0.27 Neutral MSH2 P43246 S515T 515 S T 0.024 Neutral MSH2 P43246 S515V 515 S V 0.398 Neutral MSH2 P43246 S515W 515 S W 0.718 Pathogenic MSH2 P43246 S515Y 515 S Y 0.552 Pathogenic MSH2 P43246 S516A 516 S A 0.052 Neutral MSH2 P43246 S516C 516 S C 0.52 Pathogenic MSH2 P43246 S516D 516 S D 0.558 Pathogenic MSH2 P43246 S516E 516 S E 0.762 Pathogenic MSH2 P43246 S516F 516 S F 0.892 Pathogenic MSH2 P43246 S516G 516 S G 0.398 Neutral MSH2 P43246 S516H 516 S H 0.48 Neutral MSH2 P43246 S516I 516 S I 0.634 Pathogenic MSH2 P43246 S516K 516 S K 0.766 Pathogenic MSH2 P43246 S516L 516 S L 0.652 Pathogenic MSH2 P43246 S516M 516 S M 0.886 Pathogenic MSH2 P43246 S516N 516 S N 0.052 Neutral MSH2 P43246 S516P 516 S P 0.668 Pathogenic MSH2 P43246 S516Q 516 S Q 0.574 Pathogenic MSH2 P43246 S516R 516 S R 0.826 Pathogenic MSH2 P43246 S516T 516 S T 0.056 Neutral MSH2 P43246 S516V 516 S V 0.084 Neutral MSH2 P43246 S516W 516 S W 0.948 Pathogenic MSH2 P43246 S516Y 516 S Y 0.932 Pathogenic MSH2 P43246 A517C 517 A C 0.638 Pathogenic MSH2 P43246 A517D 517 A D 0.636 Pathogenic MSH2 P43246 A517E 517 A E 0.666 Pathogenic MSH2 P43246 A517F 517 A F 0.924 Pathogenic MSH2 P43246 A517G 517 A G 0.084 Neutral MSH2 P43246 A517H 517 A H 0.488 Neutral MSH2 P43246 A517I 517 A I 0.738 Pathogenic MSH2 P43246 A517K 517 A K 0.51 Pathogenic MSH2 P43246 A517L 517 A L 0.892 Pathogenic MSH2 P43246 A517M 517 A M 0.772 Pathogenic MSH2 P43246 A517N 517 A N 0.538 Pathogenic MSH2 P43246 A517P 517 A P 0.11 Neutral MSH2 P43246 A517Q 517 A Q 0.478 Neutral MSH2 P43246 A517R 517 A R 0.558 Pathogenic MSH2 P43246 A517S 517 A S 0.016 Neutral MSH2 P43246 A517T 517 A T 0.04 Neutral MSH2 P43246 A517V 517 A V 0.728 Pathogenic MSH2 P43246 A517W 517 A W 0.918 Pathogenic MSH2 P43246 A517Y 517 A Y 0.91 Pathogenic MSH2 P43246 Q518A 518 Q A 0.224 Neutral MSH2 P43246 Q518C 518 Q C 0.49 Neutral MSH2 P43246 Q518D 518 Q D 0.328 Neutral MSH2 P43246 Q518E 518 Q E 0.584 Pathogenic MSH2 P43246 Q518F 518 Q F 0.84 Pathogenic MSH2 P43246 Q518G 518 Q G 0.462 Neutral MSH2 P43246 Q518H 518 Q H 0.092 Neutral MSH2 P43246 Q518I 518 Q I 0.342 Neutral MSH2 P43246 Q518K 518 Q K 0.054 Neutral MSH2 P43246 Q518L 518 Q L 0.204 Neutral MSH2 P43246 Q518M 518 Q M 0.07 Neutral MSH2 P43246 Q518N 518 Q N 0.092 Neutral MSH2 P43246 Q518P 518 Q P 0.798 Pathogenic MSH2 P43246 Q518R 518 Q R 0.582 Pathogenic MSH2 P43246 Q518S 518 Q S 0.096 Neutral MSH2 P43246 Q518T 518 Q T 0.02 Neutral MSH2 P43246 Q518V 518 Q V 0.094 Neutral MSH2 P43246 Q518W 518 Q W 0.926 Pathogenic MSH2 P43246 Q518Y 518 Q Y 0.888 Pathogenic MSH2 P43246 F519A 519 F A 0.242 Neutral MSH2 P43246 F519C 519 F C 0.292 Neutral MSH2 P43246 F519D 519 F D 0.128 Neutral MSH2 P43246 F519E 519 F E 0.662 Pathogenic MSH2 P43246 F519G 519 F G 0.36 Neutral MSH2 P43246 F519H 519 F H 0.014 Neutral MSH2 P43246 F519I 519 F I 0.05 Neutral MSH2 P43246 F519K 519 F K 0.264 Neutral MSH2 P43246 F519L 519 F L 0.02 Neutral 1 MSH2 P43246 F519M 519 F M 0.138 Neutral MSH2 P43246 F519N 519 F N 0.144 Neutral MSH2 P43246 F519P 519 F P 0.762 Pathogenic MSH2 P43246 F519Q 519 F Q 0.506 Pathogenic MSH2 P43246 F519R 519 F R 0.528 Pathogenic MSH2 P43246 F519S 519 F S 0.43 Neutral MSH2 P43246 F519T 519 F T 0.22 Neutral MSH2 P43246 F519V 519 F V 0.08 Neutral MSH2 P43246 F519W 519 F W 0.728 Pathogenic MSH2 P43246 F519Y 519 F Y 0.048 Neutral MSH2 P43246 L52A 52 L A 0.116 Neutral MSH2 P43246 L52C 52 L C 0.414 Neutral MSH2 P43246 L52D 52 L D 0.66 Pathogenic MSH2 P43246 L52E 52 L E 0.074 Neutral MSH2 P43246 L52F 52 L F 0.382 Neutral MSH2 P43246 L52G 52 L G 0.57 Pathogenic MSH2 P43246 L52H 52 L H 0.444 Neutral MSH2 P43246 L52I 52 L I 0.326 Neutral MSH2 P43246 L52K 52 L K 0.442 Neutral MSH2 P43246 L52M 52 L M 0.428 Neutral MSH2 P43246 L52N 52 L N 0.46 Neutral MSH2 P43246 L52P 52 L P 0.888 Pathogenic MSH2 P43246 L52Q 52 L Q 0.192 Neutral MSH2 P43246 L52R 52 L R 0.856 Pathogenic MSH2 P43246 L52S 52 L S 0.35 Neutral MSH2 P43246 L52T 52 L T 0.316 Neutral MSH2 P43246 L52V 52 L V 0.034 Neutral MSH2 P43246 L52W 52 L W 0.816 Pathogenic MSH2 P43246 L52Y 52 L Y 0.614 Pathogenic MSH2 P43246 G520A 520 G A 0.964 Pathogenic MSH2 P43246 G520C 520 G C 0.946 Pathogenic MSH2 P43246 G520D 520 G D 0.998 Pathogenic MSH2 P43246 G520E 520 G E 0.874 Pathogenic MSH2 P43246 G520F 520 G F 0.98 Pathogenic MSH2 P43246 G520H 520 G H 0.984 Pathogenic MSH2 P43246 G520I 520 G I 0.944 Pathogenic MSH2 P43246 G520K 520 G K 0.926 Pathogenic MSH2 P43246 G520L 520 G L 0.98 Pathogenic MSH2 P43246 G520M 520 G M 0.86 Pathogenic MSH2 P43246 G520N 520 G N 0.78 Pathogenic MSH2 P43246 G520P 520 G P 0.962 Pathogenic MSH2 P43246 G520Q 520 G Q 0.784 Pathogenic MSH2 P43246 G520R 520 G R 0.924 Pathogenic MSH2 P43246 G520S 520 G S 0.824 Pathogenic MSH2 P43246 G520T 520 G T 0.838 Pathogenic MSH2 P43246 G520V 520 G V 0.982 Pathogenic MSH2 P43246 G520W 520 G W 0.976 Pathogenic MSH2 P43246 G520Y 520 G Y 0.956 Pathogenic MSH2 P43246 Y521A 521 Y A 0.336 Neutral MSH2 P43246 Y521C 521 Y C 0.286 Neutral MSH2 P43246 Y521D 521 Y D 0.8 Pathogenic MSH2 P43246 Y521E 521 Y E 0.44 Neutral MSH2 P43246 Y521F 521 Y F 0.076 Neutral MSH2 P43246 Y521G 521 Y G 0.382 Neutral MSH2 P43246 Y521H 521 Y H 0.1 Neutral MSH2 P43246 Y521I 521 Y I 0.662 Pathogenic MSH2 P43246 Y521K 521 Y K 0.826 Pathogenic MSH2 P43246 Y521L 521 Y L 0.544 Pathogenic MSH2 P43246 Y521M 521 Y M 0.598 Pathogenic MSH2 P43246 Y521N 521 Y N 0.344 Neutral MSH2 P43246 Y521P 521 Y P 0.684 Pathogenic MSH2 P43246 Y521Q 521 Y Q 0.304 Neutral MSH2 P43246 Y521R 521 Y R 0.466 Neutral MSH2 P43246 Y521S 521 Y S 0.38 Neutral MSH2 P43246 Y521T 521 Y T 0.538 Pathogenic MSH2 P43246 Y521V 521 Y V 0.148 Neutral MSH2 P43246 Y521W 521 Y W 0.202 Neutral MSH2 P43246 Y522A 522 Y A 0.196 Neutral MSH2 P43246 Y522C 522 Y C 0.212 Neutral MSH2 P43246 Y522D 522 Y D 0.568 Pathogenic MSH2 P43246 Y522E 522 Y E 0.554 Pathogenic MSH2 P43246 Y522F 522 Y F 0.024 Neutral MSH2 P43246 Y522G 522 Y G 0.282 Neutral MSH2 P43246 Y522H 522 Y H 0.028 Neutral MSH2 P43246 Y522I 522 Y I 0.242 Neutral MSH2 P43246 Y522K 522 Y K 0.552 Pathogenic MSH2 P43246 Y522L 522 Y L 0.056 Neutral MSH2 P43246 Y522M 522 Y M 0.344 Neutral MSH2 P43246 Y522N 522 Y N 0.292 Neutral MSH2 P43246 Y522P 522 Y P 0.42 Neutral MSH2 P43246 Y522Q 522 Y Q 0.372 Neutral MSH2 P43246 Y522R 522 Y R 0.596 Pathogenic MSH2 P43246 Y522S 522 Y S 0.274 Neutral MSH2 P43246 Y522T 522 Y T 0.234 Neutral MSH2 P43246 Y522V 522 Y V 0.032 Neutral MSH2 P43246 Y522W 522 Y W 0.552 Pathogenic MSH2 P43246 F523A 523 F A 0.506 Pathogenic MSH2 P43246 F523C 523 F C 0.71 Pathogenic MSH2 P43246 F523D 523 F D 0.794 Pathogenic MSH2 P43246 F523E 523 F E 0.854 Pathogenic MSH2 P43246 F523G 523 F G 0.488 Neutral MSH2 P43246 F523H 523 F H 0.758 Pathogenic MSH2 P43246 F523I 523 F I 0.296 Neutral MSH2 P43246 F523K 523 F K 0.838 Pathogenic MSH2 P43246 F523L 523 F L 0.154 Neutral MSH2 P43246 F523M 523 F M 0.158 Neutral MSH2 P43246 F523N 523 F N 0.71 Pathogenic MSH2 P43246 F523P 523 F P 0.956 Pathogenic MSH2 P43246 F523Q 523 F Q 0.73 Pathogenic MSH2 P43246 F523R 523 F R 0.908 Pathogenic MSH2 P43246 F523S 523 F S 0.816 Pathogenic MSH2 P43246 F523T 523 F T 0.588 Pathogenic MSH2 P43246 F523V 523 F V 0.378 Neutral MSH2 P43246 F523W 523 F W 0.92 Pathogenic MSH2 P43246 F523Y 523 F Y 0.68 Pathogenic MSH2 P43246 R524A 524 R A 0.574 Pathogenic MSH2 P43246 R524C 524 R C 0.96 Pathogenic MSH2 P43246 R524D 524 R D 0.714 Pathogenic MSH2 P43246 R524E 524 R E 0.814 Pathogenic MSH2 P43246 R524F 524 R F 0.976 Pathogenic MSH2 P43246 R524G 524 R G 0.404 Neutral MSH2 P43246 R524H 524 R H 0.432 Neutral MSH2 P43246 R524I 524 R I 0.98 Pathogenic MSH2 P43246 R524K 524 R K 0.784 Pathogenic MSH2 P43246 R524L 524 R L 0.994 Pathogenic 4 MSH2 P43246 R524M 524 R M 0.8 Pathogenic MSH2 P43246 R524N 524 R N 0.674 Pathogenic MSH2 P43246 R524P 524 R P 0.992 Pathogenic 4 MSH2 P43246 R524Q 524 R Q 0.424 Neutral MSH2 P43246 R524S 524 R S 0.924 Pathogenic MSH2 P43246 R524T 524 R T 0.958 Pathogenic MSH2 P43246 R524V 524 R V 0.764 Pathogenic MSH2 P43246 R524W 524 R W 0.96 Pathogenic MSH2 P43246 R524Y 524 R Y 0.97 Pathogenic MSH2 P43246 V525A 525 V A 0.328 Neutral MSH2 P43246 V525C 525 V C 0.712 Pathogenic MSH2 P43246 V525D 525 V D 0.862 Pathogenic MSH2 P43246 V525E 525 V E 0.978 Pathogenic MSH2 P43246 V525F 525 V F 0.88 Pathogenic MSH2 P43246 V525G 525 V G 0.892 Pathogenic MSH2 P43246 V525H 525 V H 0.822 Pathogenic MSH2 P43246 V525I 525 V I 0.176 Neutral MSH2 P43246 V525K 525 V K 0.99 Pathogenic MSH2 P43246 V525L 525 V L 0.182 Neutral MSH2 P43246 V525M 525 V M 0.424 Neutral MSH2 P43246 V525N 525 V N 0.922 Pathogenic MSH2 P43246 V525P 525 V P 0.984 Pathogenic MSH2 P43246 V525Q 525 V Q 0.984 Pathogenic MSH2 P43246 V525R 525 V R 0.952 Pathogenic MSH2 P43246 V525S 525 V S 0.722 Pathogenic MSH2 P43246 V525T 525 V T 0.174 Neutral MSH2 P43246 V525W 525 V W 0.908 Pathogenic MSH2 P43246 V525Y 525 V Y 0.932 Pathogenic MSH2 P43246 T526A 526 T A 0.706 Pathogenic MSH2 P43246 T526C 526 T C 0.936 Pathogenic MSH2 P43246 T526D 526 T D 0.948 Pathogenic MSH2 P43246 T526E 526 T E 0.95 Pathogenic MSH2 P43246 T526F 526 T F 0.95 Pathogenic MSH2 P43246 T526G 526 T G 0.742 Pathogenic MSH2 P43246 T526H 526 T H 0.922 Pathogenic MSH2 P43246 T526I 526 T I 0.704 Pathogenic MSH2 P43246 T526K 526 T K 0.94 Pathogenic MSH2 P43246 T526L 526 T L 0.948 Pathogenic MSH2 P43246 T526M 526 T M 0.982 Pathogenic MSH2 P43246 T526N 526 T N 0.894 Pathogenic MSH2 P43246 T526P 526 T P 0.616 Pathogenic MSH2 P43246 T526Q 526 T Q 0.892 Pathogenic MSH2 P43246 T526R 526 T R 0.994 Pathogenic MSH2 P43246 T526S 526 T S 0.338 Neutral MSH2 P43246 T526V 526 T V 0.746 Pathogenic MSH2 P43246 T526W 526 T W 0.972 Pathogenic MSH2 P43246 T526Y 526 T Y 0.972 Pathogenic MSH2 P43246 C527A 527 C A 0.594 Pathogenic MSH2 P43246 C527D 527 C D 0.872 Pathogenic MSH2 P43246 C527E 527 C E 0.892 Pathogenic MSH2 P43246 C527F 527 C F 0.998 Pathogenic MSH2 P43246 C527G 527 C G 0.888 Pathogenic MSH2 P43246 C527H 527 C H 0.9 Pathogenic MSH2 P43246 C527I 527 C I 0.956 Pathogenic MSH2 P43246 C527K 527 C K 0.44 Neutral MSH2 P43246 C527L 527 C L 0.404 Neutral MSH2 P43246 C527M 527 C M 0.81 Pathogenic MSH2 P43246 C527N 527 C N 0.688 Pathogenic MSH2 P43246 C527P 527 C P 0.976 Pathogenic MSH2 P43246 C527Q 527 C Q 0.744 Pathogenic MSH2 P43246 C527R 527 C R 0.546 Pathogenic MSH2 P43246 C527S 527 C S 0.622 Pathogenic MSH2 P43246 C527T 527 C T 0.368 Neutral MSH2 P43246 C527V 527 C V 0.956 Pathogenic MSH2 P43246 C527W 527 C W 0.996 Pathogenic MSH2 P43246 C527Y 527 C Y 0.78 Pathogenic MSH2 P43246 K528A 528 K A 0.104 Neutral MSH2 P43246 K528C 528 K C 0.17 Neutral MSH2 P43246 K528D 528 K D 0.036 Neutral MSH2 P43246 K528E 528 K E 0.038 Neutral MSH2 P43246 K528F 528 K F 0.77 Pathogenic MSH2 P43246 K528G 528 K G 0.31 Neutral MSH2 P43246 K528H 528 K H 0.28 Neutral MSH2 P43246 K528I 528 K I 0.822 Pathogenic MSH2 P43246 K528L 528 K L 0.488 Neutral MSH2 P43246 K528M 528 K M 0.558 Pathogenic MSH2 P43246 K528N 528 K N 0.042 Neutral MSH2 P43246 K528P 528 K P 0.79 Pathogenic MSH2 P43246 K528Q 528 K Q 0.054 Neutral MSH2 P43246 K528R 528 K R 0.044 Neutral MSH2 P43246 K528S 528 K S 0.056 Neutral MSH2 P43246 K528T 528 K T 0.042 Neutral MSH2 P43246 K528V 528 K V 0.718 Pathogenic MSH2 P43246 K528W 528 K W 0.95 Pathogenic MSH2 P43246 K528Y 528 K Y 0.888 Pathogenic MSH2 P43246 E529A 529 E A 0.804 Pathogenic MSH2 P43246 E529C 529 E C 0.744 Pathogenic MSH2 P43246 E529D 529 E D 0.188 Neutral MSH2 P43246 E529F 529 E F 0.95 Pathogenic MSH2 P43246 E529G 529 E G 0.374 Neutral MSH2 P43246 E529H 529 E H 0.528 Pathogenic MSH2 P43246 E529I 529 E I 0.972 Pathogenic MSH2 P43246 E529K 529 E K 0.888 Pathogenic MSH2 P43246 E529L 529 E L 0.958 Pathogenic MSH2 P43246 E529M 529 E M 0.892 Pathogenic MSH2 P43246 E529N 529 E N 0.764 Pathogenic MSH2 P43246 E529P 529 E P 0.928 Pathogenic MSH2 P43246 E529Q 529 E Q 0.348 Neutral MSH2 P43246 E529R 529 E R 0.924 Pathogenic MSH2 P43246 E529S 529 E S 0.31 Neutral MSH2 P43246 E529T 529 E T 0.334 Neutral MSH2 P43246 E529V 529 E V 0.636 Pathogenic MSH2 P43246 E529W 529 E W 0.972 Pathogenic MSH2 P43246 E529Y 529 E Y 0.88 Pathogenic MSH2 P43246 A53C 53 A C 0.734 Pathogenic MSH2 P43246 A53D 53 A D 0.846 Pathogenic MSH2 P43246 A53E 53 A E 0.866 Pathogenic MSH2 P43246 A53F 53 A F 0.56 Pathogenic MSH2 P43246 A53G 53 A G 0.51 Pathogenic MSH2 P43246 A53H 53 A H 0.854 Pathogenic MSH2 P43246 A53I 53 A I 0.636 Pathogenic MSH2 P43246 A53K 53 A K 0.9 Pathogenic MSH2 P43246 A53L 53 A L 0.572 Pathogenic MSH2 P43246 A53M 53 A M 0.788 Pathogenic MSH2 P43246 A53N 53 A N 0.766 Pathogenic MSH2 P43246 A53P 53 A P 0.93 Pathogenic MSH2 P43246 A53Q 53 A Q 0.706 Pathogenic MSH2 P43246 A53R 53 A R 0.908 Pathogenic MSH2 P43246 A53S 53 A S 0.424 Neutral MSH2 P43246 A53T 53 A T 0.174 Neutral MSH2 P43246 A53V 53 A V 0.142 Neutral MSH2 P43246 A53W 53 A W 0.95 Pathogenic MSH2 P43246 A53Y 53 A Y 0.934 Pathogenic MSH2 P43246 E530A 530 E A 0.228 Neutral MSH2 P43246 E530C 530 E C 0.48 Neutral MSH2 P43246 E530D 530 E D 0.026 Neutral MSH2 P43246 E530F 530 E F 0.826 Pathogenic MSH2 P43246 E530G 530 E G 0.05 Neutral MSH2 P43246 E530H 530 E H 0.548 Pathogenic MSH2 P43246 E530I 530 E I 0.888 Pathogenic MSH2 P43246 E530K 530 E K 0.078 Neutral MSH2 P43246 E530L 530 E L 0.846 Pathogenic MSH2 P43246 E530M 530 E M 0.654 Pathogenic MSH2 P43246 E530N 530 E N 0.366 Neutral MSH2 P43246 E530P 530 E P 0.146 Neutral MSH2 P43246 E530Q 530 E Q 0.026 Neutral MSH2 P43246 E530R 530 E R 0.606 Pathogenic MSH2 P43246 E530S 530 E S 0.044 Neutral MSH2 P43246 E530T 530 E T 0.058 Neutral MSH2 P43246 E530V 530 E V 0.224 Neutral MSH2 P43246 E530W 530 E W 0.906 Pathogenic MSH2 P43246 E530Y 530 E Y 0.858 Pathogenic MSH2 P43246 K531A 531 K A 0.104 Neutral MSH2 P43246 K531C 531 K C 0.114 Neutral MSH2 P43246 K531D 531 K D 0.594 Pathogenic MSH2 P43246 K531E 531 K E 0.248 Neutral MSH2 P43246 K531F 531 K F 0.918 Pathogenic MSH2 P43246 K531G 531 K G 0.166 Neutral MSH2 P43246 K531H 531 K H 0.708 Pathogenic MSH2 P43246 K531I 531 K I 0.974 Pathogenic MSH2 P43246 K531L 531 K L 0.442 Neutral MSH2 P43246 K531M 531 K M 0.826 Pathogenic MSH2 P43246 K531N 531 K N 0.116 Neutral MSH2 P43246 K531P 531 K P 0.64 Pathogenic MSH2 P43246 K531Q 531 K Q 0.714 Pathogenic MSH2 P43246 K531R 531 K R 0.124 Neutral MSH2 P43246 K531S 531 K S 0.126 Neutral MSH2 P43246 K531T 531 K T 0.118 Neutral MSH2 P43246 K531V 531 K V 0.508 Pathogenic MSH2 P43246 K531W 531 K W 0.978 Pathogenic MSH2 P43246 K531Y 531 K Y 0.964 Pathogenic MSH2 P43246 V532A 532 V A 0.024 Neutral MSH2 P43246 V532C 532 V C 0.04 Neutral MSH2 P43246 V532D 532 V D 0.548 Pathogenic MSH2 P43246 V532E 532 V E 0.114 Neutral MSH2 P43246 V532F 532 V F 0.744 Pathogenic MSH2 P43246 V532G 532 V G 0.138 Neutral MSH2 P43246 V532H 532 V H 0.344 Neutral MSH2 P43246 V532I 532 V I 0.066 Neutral MSH2 P43246 V532K 532 V K 0.2 Neutral MSH2 P43246 V532L 532 V L 0.058 Neutral MSH2 P43246 V532M 532 V M 0.45 Neutral MSH2 P43246 V532N 532 V N 0.09 Neutral MSH2 P43246 V532P 532 V P 0.812 Pathogenic MSH2 P43246 V532Q 532 V Q 0.68 Pathogenic MSH2 P43246 V532R 532 V R 0.536 Pathogenic MSH2 P43246 V532S 532 V S 0.05 Neutral MSH2 P43246 V532T 532 V T 0.06 Neutral MSH2 P43246 V532W 532 V W 0.822 Pathogenic MSH2 P43246 V532Y 532 V Y 0.814 Pathogenic MSH2 P43246 L533A 533 L A 0.564 Pathogenic MSH2 P43246 L533C 533 L C 0.682 Pathogenic MSH2 P43246 L533D 533 L D 0.902 Pathogenic MSH2 P43246 L533E 533 L E 0.882 Pathogenic MSH2 P43246 L533F 533 L F 0.976 Pathogenic MSH2 P43246 L533G 533 L G 0.806 Pathogenic MSH2 P43246 L533H 533 L H 0.8 Pathogenic MSH2 P43246 L533I 533 L I 0.102 Neutral MSH2 P43246 L533K 533 L K 0.75 Pathogenic MSH2 P43246 L533M 533 L M 0.458 Neutral MSH2 P43246 L533N 533 L N 0.772 Pathogenic MSH2 P43246 L533P 533 L P 0.998 Pathogenic MSH2 P43246 L533Q 533 L Q 0.616 Pathogenic MSH2 P43246 L533R 533 L R 0.518 Pathogenic MSH2 P43246 L533S 533 L S 0.184 Neutral MSH2 P43246 L533T 533 L T 0.59 Pathogenic MSH2 P43246 L533V 533 L V 0.072 Neutral MSH2 P43246 L533W 533 L W 0.94 Pathogenic MSH2 P43246 L533Y 533 L Y 0.902 Pathogenic MSH2 P43246 R534A 534 R A 0.286 Neutral MSH2 P43246 R534C 534 R C 0.942 Pathogenic MSH2 P43246 R534D 534 R D 0.2 Neutral MSH2 P43246 R534E 534 R E 0.2 Neutral MSH2 P43246 R534F 534 R F 0.96 Pathogenic MSH2 P43246 R534G 534 R G 0.1 Neutral MSH2 P43246 R534H 534 R H 0.184 Neutral MSH2 P43246 R534I 534 R I 0.448 Neutral MSH2 P43246 R534K 534 R K 0.35 Neutral MSH2 P43246 R534L 534 R L 0.692 Pathogenic MSH2 P43246 R534M 534 R M 0.522 Pathogenic MSH2 P43246 R534N 534 R N 0.182 Neutral MSH2 P43246 R534P 534 R P 0.978 Pathogenic MSH2 P43246 R534Q 534 R Q 0.35 Neutral MSH2 P43246 R534S 534 R S 0.176 Neutral MSH2 P43246 R534T 534 R T 0.196 Neutral MSH2 P43246 R534V 534 R V 0.966 Pathogenic MSH2 P43246 R534W 534 R W 0.968 Pathogenic MSH2 P43246 R534Y 534 R Y 0.964 Pathogenic MSH2 P43246 N535A 535 N A 0.386 Neutral MSH2 P43246 N535C 535 N C 0.738 Pathogenic MSH2 P43246 N535D 535 N D 0.366 Neutral MSH2 P43246 N535E 535 N E 0.69 Pathogenic MSH2 P43246 N535F 535 N F 0.964 Pathogenic MSH2 P43246 N535G 535 N G 0.172 Neutral MSH2 P43246 N535H 535 N H 0.914 Pathogenic MSH2 P43246 N535I 535 N I 0.944 Pathogenic MSH2 P43246 N535K 535 N K 0.37 Neutral MSH2 P43246 N535L 535 N L 0.958 Pathogenic MSH2 P43246 N535M 535 N M 0.828 Pathogenic MSH2 P43246 N535P 535 N P 0.854 Pathogenic MSH2 P43246 N535Q 535 N Q 0.216 Neutral MSH2 P43246 N535R 535 N R 0.586 Pathogenic MSH2 P43246 N535S 535 N S 0.182 Neutral MSH2 P43246 N535T 535 N T 0.512 Pathogenic MSH2 P43246 N535V 535 N V 0.98 Pathogenic MSH2 P43246 N535W 535 N W 0.97 Pathogenic MSH2 P43246 N535Y 535 N Y 0.964 Pathogenic MSH2 P43246 N536A 536 N A 0.35 Neutral MSH2 P43246 N536C 536 N C 0.288 Neutral MSH2 P43246 N536D 536 N D 0.118 Neutral MSH2 P43246 N536E 536 N E 0.272 Neutral MSH2 P43246 N536F 536 N F 0.922 Pathogenic MSH2 P43246 N536G 536 N G 0.252 Neutral MSH2 P43246 N536H 536 N H 0.084 Neutral MSH2 P43246 N536I 536 N I 0.9 Pathogenic MSH2 P43246 N536K 536 N K 0.098 Neutral MSH2 P43246 N536L 536 N L 0.162 Neutral MSH2 P43246 N536M 536 N M 0.87 Pathogenic MSH2 P43246 N536P 536 N P 0.752 Pathogenic MSH2 P43246 N536Q 536 N Q 0.058 Neutral MSH2 P43246 N536R 536 N R 0.546 Pathogenic MSH2 P43246 N536S 536 N S 0.06 Neutral MSH2 P43246 N536T 536 N T 0.51 Pathogenic MSH2 P43246 N536V 536 N V 0.79 Pathogenic MSH2 P43246 N536W 536 N W 0.946 Pathogenic MSH2 P43246 N536Y 536 N Y 0.938 Pathogenic MSH2 P43246 K537A 537 K A 0.072 Neutral MSH2 P43246 K537C 537 K C 0.21 Neutral MSH2 P43246 K537D 537 K D 0.34 Neutral MSH2 P43246 K537E 537 K E 0.402 Neutral MSH2 P43246 K537F 537 K F 0.79 Pathogenic MSH2 P43246 K537G 537 K G 0.272 Neutral MSH2 P43246 K537H 537 K H 0.426 Neutral MSH2 P43246 K537I 537 K I 0.854 Pathogenic MSH2 P43246 K537L 537 K L 0.628 Pathogenic MSH2 P43246 K537M 537 K M 0.47 Neutral MSH2 P43246 K537N 537 K N 0.028 Neutral MSH2 P43246 K537P 537 K P 0.334 Neutral MSH2 P43246 K537Q 537 K Q 0.086 Neutral MSH2 P43246 K537R 537 K R 0.042 Neutral MSH2 P43246 K537S 537 K S 0.032 Neutral MSH2 P43246 K537T 537 K T 0.04 Neutral MSH2 P43246 K537V 537 K V 0.548 Pathogenic MSH2 P43246 K537W 537 K W 0.936 Pathogenic MSH2 P43246 K537Y 537 K Y 0.884 Pathogenic MSH2 P43246 N538A 538 N A 0.084 Neutral MSH2 P43246 N538C 538 N C 0.604 Pathogenic MSH2 P43246 N538D 538 N D 0.048 Neutral MSH2 P43246 N538E 538 N E 0.038 Neutral MSH2 P43246 N538F 538 N F 0.86 Pathogenic MSH2 P43246 N538G 538 N G 0.042 Neutral MSH2 P43246 N538H 538 N H 0.064 Neutral MSH2 P43246 N538I 538 N I 0.824 Pathogenic MSH2 P43246 N538K 538 N K 0.072 Neutral MSH2 P43246 N538L 538 N L 0.82 Pathogenic MSH2 P43246 N538M 538 N M 0.78 Pathogenic MSH2 P43246 N538P 538 N P 0.718 Pathogenic MSH2 P43246 N538Q 538 N Q 0.02 Neutral MSH2 P43246 N538R 538 N R 0.41 Neutral MSH2 P43246 N538S 538 N S 0.018 Neutral MSH2 P43246 N538T 538 N T 0.028 Neutral MSH2 P43246 N538V 538 N V 0.234 Neutral MSH2 P43246 N538W 538 N W 0.924 Pathogenic MSH2 P43246 N538Y 538 N Y 0.908 Pathogenic MSH2 P43246 F539A 539 F A 0.51 Pathogenic MSH2 P43246 F539C 539 F C 0.718 Pathogenic MSH2 P43246 F539D 539 F D 0.8 Pathogenic MSH2 P43246 F539E 539 F E 0.848 Pathogenic MSH2 P43246 F539G 539 F G 0.494 Neutral MSH2 P43246 F539H 539 F H 0.76 Pathogenic MSH2 P43246 F539I 539 F I 0.194 Neutral MSH2 P43246 F539K 539 F K 0.836 Pathogenic MSH2 P43246 F539L 539 F L 0.694 Pathogenic MSH2 P43246 F539M 539 F M 0.78 Pathogenic MSH2 P43246 F539N 539 F N 0.72 Pathogenic MSH2 P43246 F539P 539 F P 0.966 Pathogenic MSH2 P43246 F539Q 539 F Q 0.732 Pathogenic MSH2 P43246 F539R 539 F R 0.532 Pathogenic MSH2 P43246 F539S 539 F S 0.834 Pathogenic MSH2 P43246 F539T 539 F T 0.572 Pathogenic MSH2 P43246 F539V 539 F V 0.806 Pathogenic MSH2 P43246 F539W 539 F W 0.744 Pathogenic MSH2 P43246 F539Y 539 F Y 0.322 Neutral MSH2 P43246 A54C 54 A C 0.846 Pathogenic MSH2 P43246 A54D 54 A D 0.912 Pathogenic MSH2 P43246 A54E 54 A E 0.866 Pathogenic MSH2 P43246 A54F 54 A F 0.95 Pathogenic MSH2 P43246 A54G 54 A G 0.742 Pathogenic MSH2 P43246 A54H 54 A H 0.852 Pathogenic MSH2 P43246 A54I 54 A I 0.738 Pathogenic MSH2 P43246 A54K 54 A K 0.918 Pathogenic MSH2 P43246 A54L 54 A L 0.964 Pathogenic MSH2 P43246 A54M 54 A M 0.834 Pathogenic MSH2 P43246 A54N 54 A N 0.842 Pathogenic MSH2 P43246 A54P 54 A P 0.962 Pathogenic MSH2 P43246 A54Q 54 A Q 0.808 Pathogenic MSH2 P43246 A54R 54 A R 0.752 Pathogenic MSH2 P43246 A54S 54 A S 0.104 Neutral MSH2 P43246 A54T 54 A T 0.71 Pathogenic MSH2 P43246 A54V 54 A V 0.416 Neutral MSH2 P43246 A54W 54 A W 0.96 Pathogenic MSH2 P43246 A54Y 54 A Y 0.954 Pathogenic MSH2 P43246 S540A 540 S A 0.416 Neutral MSH2 P43246 S540C 540 S C 0.356 Neutral MSH2 P43246 S540D 540 S D 0.378 Neutral MSH2 P43246 S540E 540 S E 0.49 Neutral MSH2 P43246 S540F 540 S F 0.772 Pathogenic MSH2 P43246 S540G 540 S G 0.29 Neutral MSH2 P43246 S540H 540 S H 0.424 Neutral MSH2 P43246 S540I 540 S I 0.316 Neutral MSH2 P43246 S540K 540 S K 0.384 Neutral MSH2 P43246 S540L 540 S L 0.106 Neutral MSH2 P43246 S540M 540 S M 0.536 Pathogenic MSH2 P43246 S540N 540 S N 0.038 Neutral MSH2 P43246 S540P 540 S P 0.184 Neutral MSH2 P43246 S540Q 540 S Q 0.406 Neutral MSH2 P43246 S540R 540 S R 0.398 Neutral MSH2 P43246 S540T 540 S T 0.034 Neutral MSH2 P43246 S540V 540 S V 0.202 Neutral MSH2 P43246 S540W 540 S W 0.916 Pathogenic MSH2 P43246 S540Y 540 S Y 0.89 Pathogenic MSH2 P43246 T541A 541 T A 0.444 Neutral MSH2 P43246 T541C 541 T C 0.586 Pathogenic MSH2 P43246 T541D 541 T D 0.106 Neutral MSH2 P43246 T541E 541 T E 0.246 Neutral MSH2 P43246 T541F 541 T F 0.632 Pathogenic MSH2 P43246 T541G 541 T G 0.328 Neutral MSH2 P43246 T541H 541 T H 0.644 Pathogenic MSH2 P43246 T541I 541 T I 0.152 Neutral MSH2 P43246 T541K 541 T K 0.424 Neutral MSH2 P43246 T541L 541 T L 0.632 Pathogenic MSH2 P43246 T541M 541 T M 0.202 Neutral MSH2 P43246 T541N 541 T N 0.428 Neutral MSH2 P43246 T541P 541 T P 0.686 Pathogenic MSH2 P43246 T541Q 541 T Q 0.062 Neutral MSH2 P43246 T541R 541 T R 0.858 Pathogenic MSH2 P43246 T541S 541 T S 0.406 Neutral MSH2 P43246 T541V 541 T V 0.092 Neutral MSH2 P43246 T541W 541 T W 0.912 Pathogenic MSH2 P43246 T541Y 541 T Y 0.908 Pathogenic MSH2 P43246 V542A 542 V A 0.328 Neutral MSH2 P43246 V542C 542 V C 0.11 Neutral MSH2 P43246 V542D 542 V D 0.862 Pathogenic MSH2 P43246 V542E 542 V E 0.582 Pathogenic MSH2 P43246 V542F 542 V F 0.636 Pathogenic MSH2 P43246 V542G 542 V G 0.902 Pathogenic MSH2 P43246 V542H 542 V H 0.43 Neutral MSH2 P43246 V542I 542 V I 0.162 Neutral MSH2 P43246 V542K 542 V K 0.96 Pathogenic MSH2 P43246 V542L 542 V L 0.196 Neutral MSH2 P43246 V542M 542 V M 0.786 Pathogenic MSH2 P43246 V542N 542 V N 0.93 Pathogenic MSH2 P43246 V542P 542 V P 0.962 Pathogenic MSH2 P43246 V542Q 542 V Q 0.988 Pathogenic MSH2 P43246 V542R 542 V R 0.956 Pathogenic MSH2 P43246 V542S 542 V S 0.734 Pathogenic MSH2 P43246 V542T 542 V T 0.29 Neutral MSH2 P43246 V542W 542 V W 0.898 Pathogenic MSH2 P43246 V542Y 542 V Y 0.522 Pathogenic MSH2 P43246 D543A 543 D A 0.114 Neutral MSH2 P43246 D543C 543 D C 0.554 Pathogenic MSH2 P43246 D543E 543 D E 0.044 Neutral MSH2 P43246 D543F 543 D F 0.908 Pathogenic MSH2 P43246 D543G 543 D G 0.068 Neutral MSH2 P43246 D543H 543 D H 0.364 Neutral MSH2 P43246 D543I 543 D I 0.866 Pathogenic MSH2 P43246 D543K 543 D K 0.346 Neutral MSH2 P43246 D543L 543 D L 0.856 Pathogenic MSH2 P43246 D543M 543 D M 0.77 Pathogenic MSH2 P43246 D543N 543 D N 0.124 Neutral MSH2 P43246 D543P 543 D P 0.754 Pathogenic MSH2 P43246 D543Q 543 D Q 0.034 Neutral MSH2 P43246 D543R 543 D R 0.77 Pathogenic MSH2 P43246 D543S 543 D S 0.036 Neutral MSH2 P43246 D543T 543 D T 0.228 Neutral MSH2 P43246 D543V 543 D V 0.886 Pathogenic MSH2 P43246 D543W 543 D W 0.94 Pathogenic MSH2 P43246 D543Y 543 D Y 0.928 Pathogenic MSH2 P43246 I544A 544 I A 0.098 Neutral MSH2 P43246 I544C 544 I C 0.604 Pathogenic MSH2 P43246 I544D 544 I D 0.754 Pathogenic MSH2 P43246 I544E 544 I E 0.758 Pathogenic MSH2 P43246 I544F 544 I F 0.966 Pathogenic MSH2 P43246 I544G 544 I G 0.804 Pathogenic MSH2 P43246 I544H 544 I H 0.838 Pathogenic MSH2 P43246 I544K 544 I K 0.848 Pathogenic MSH2 P43246 I544L 544 I L 0.742 Pathogenic MSH2 P43246 I544M 544 I M 0.406 Neutral MSH2 P43246 I544N 544 I N 0.198 Neutral MSH2 P43246 I544P 544 I P 0.94 Pathogenic MSH2 P43246 I544Q 544 I Q 0.536 Pathogenic MSH2 P43246 I544R 544 I R 0.668 Pathogenic MSH2 P43246 I544S 544 I S 0.168 Neutral MSH2 P43246 I544T 544 I T 0.208 Neutral MSH2 P43246 I544V 544 I V 0.108 Neutral MSH2 P43246 I544W 544 I W 0.988 Pathogenic MSH2 P43246 I544Y 544 I Y 0.984 Pathogenic MSH2 P43246 Q545A 545 Q A 0.372 Neutral MSH2 P43246 Q545C 545 Q C 0.492 Neutral MSH2 P43246 Q545D 545 Q D 0.552 Pathogenic MSH2 P43246 Q545E 545 Q E 0.554 Pathogenic MSH2 P43246 Q545F 545 Q F 0.816 Pathogenic MSH2 P43246 Q545G 545 Q G 0.44 Neutral MSH2 P43246 Q545H 545 Q H 0.782 Pathogenic MSH2 P43246 Q545I 545 Q I 0.344 Neutral MSH2 P43246 Q545K 545 Q K 0.074 Neutral MSH2 P43246 Q545L 545 Q L 0.216 Neutral MSH2 P43246 Q545M 545 Q M 0.668 Pathogenic MSH2 P43246 Q545N 545 Q N 0.078 Neutral MSH2 P43246 Q545P 545 Q P 0.82 Pathogenic MSH2 P43246 Q545R 545 Q R 0.086 Neutral MSH2 P43246 Q545S 545 Q S 0.482 Neutral MSH2 P43246 Q545T 545 Q T 0.032 Neutral MSH2 P43246 Q545V 545 Q V 0.098 Neutral MSH2 P43246 Q545W 545 Q W 0.906 Pathogenic MSH2 P43246 Q545Y 545 Q Y 0.868 Pathogenic MSH2 P43246 K546A 546 K A 0.7 Pathogenic MSH2 P43246 K546C 546 K C 0.602 Pathogenic MSH2 P43246 K546D 546 K D 0.772 Pathogenic MSH2 P43246 K546E 546 K E 0.872 Pathogenic MSH2 P43246 K546F 546 K F 0.958 Pathogenic MSH2 P43246 K546G 546 K G 0.52 Pathogenic MSH2 P43246 K546H 546 K H 0.88 Pathogenic MSH2 P43246 K546I 546 K I 0.992 Pathogenic MSH2 P43246 K546L 546 K L 0.984 Pathogenic MSH2 P43246 K546M 546 K M 0.886 Pathogenic MSH2 P43246 K546N 546 K N 0.378 Neutral MSH2 P43246 K546P 546 K P 0.926 Pathogenic MSH2 P43246 K546Q 546 K Q 0.854 Pathogenic MSH2 P43246 K546R 546 K R 0.476 Neutral MSH2 P43246 K546S 546 K S 0.628 Pathogenic MSH2 P43246 K546T 546 K T 0.334 Neutral MSH2 P43246 K546V 546 K V 0.86 Pathogenic MSH2 P43246 K546W 546 K W 0.984 Pathogenic MSH2 P43246 K546Y 546 K Y 0.974 Pathogenic MSH2 P43246 N547A 547 N A 0.232 Neutral MSH2 P43246 N547C 547 N C 0.614 Pathogenic MSH2 P43246 N547D 547 N D 0.174 Neutral MSH2 P43246 N547E 547 N E 0.564 Pathogenic MSH2 P43246 N547F 547 N F 0.94 Pathogenic MSH2 P43246 N547G 547 N G 0.18 Neutral MSH2 P43246 N547H 547 N H 0.786 Pathogenic MSH2 P43246 N547I 547 N I 0.91 Pathogenic MSH2 P43246 N547K 547 N K 0.824 Pathogenic MSH2 P43246 N547L 547 N L 0.912 Pathogenic MSH2 P43246 N547M 547 N M 0.902 Pathogenic MSH2 P43246 N547P 547 N P 0.776 Pathogenic MSH2 P43246 N547Q 547 N Q 0.776 Pathogenic MSH2 P43246 N547R 547 N R 0.868 Pathogenic MSH2 P43246 N547S 547 N S 0.186 Neutral MSH2 P43246 N547T 547 N T 0.298 Neutral MSH2 P43246 N547V 547 N V 0.944 Pathogenic MSH2 P43246 N547W 547 N W 0.948 Pathogenic MSH2 P43246 N547Y 547 N Y 0.942 Pathogenic MSH2 P43246 G548A 548 G A 0.966 Pathogenic MSH2 P43246 G548C 548 G C 0.948 Pathogenic MSH2 P43246 G548D 548 G D 0.804 Pathogenic MSH2 P43246 G548E 548 G E 0.988 Pathogenic MSH2 P43246 G548F 548 G F 0.984 Pathogenic MSH2 P43246 G548H 548 G H 0.988 Pathogenic MSH2 P43246 G548I 548 G I 0.974 Pathogenic MSH2 P43246 G548K 548 G K 0.988 Pathogenic MSH2 P43246 G548L 548 G L 0.984 Pathogenic MSH2 P43246 G548M 548 G M 0.994 Pathogenic MSH2 P43246 G548N 548 G N 0.986 Pathogenic MSH2 P43246 G548P 548 G P 0.966 Pathogenic MSH2 P43246 G548Q 548 G Q 0.994 Pathogenic MSH2 P43246 G548R 548 G R 1 Pathogenic MSH2 P43246 G548S 548 G S 0.832 Pathogenic MSH2 P43246 G548T 548 G T 0.816 Pathogenic MSH2 P43246 G548V 548 G V 0.986 Pathogenic MSH2 P43246 G548W 548 G W 0.98 Pathogenic MSH2 P43246 G548Y 548 G Y 0.96 Pathogenic MSH2 P43246 V549A 549 V A 0.142 Neutral MSH2 P43246 V549C 549 V C 0.222 Neutral MSH2 P43246 V549D 549 V D 0.858 Pathogenic MSH2 P43246 V549E 549 V E 0.962 Pathogenic MSH2 P43246 V549F 549 V F 0.93 Pathogenic MSH2 P43246 V549G 549 V G 0.912 Pathogenic MSH2 P43246 V549H 549 V H 0.898 Pathogenic MSH2 P43246 V549I 549 V I 0.242 Neutral MSH2 P43246 V549K 549 V K 0.986 Pathogenic MSH2 P43246 V549L 549 V L 0.306 Neutral MSH2 P43246 V549M 549 V M 0.362 Neutral MSH2 P43246 V549N 549 V N 0.92 Pathogenic MSH2 P43246 V549P 549 V P 0.986 Pathogenic MSH2 P43246 V549Q 549 V Q 0.59 Pathogenic MSH2 P43246 V549R 549 V R 0.948 Pathogenic MSH2 P43246 V549S 549 V S 0.804 Pathogenic MSH2 P43246 V549T 549 V T 0.182 Neutral MSH2 P43246 V549W 549 V W 0.954 Pathogenic MSH2 P43246 V549Y 549 V Y 0.974 Pathogenic MSH2 P43246 R55A 55 R A 0.092 Neutral MSH2 P43246 R55C 55 R C 0.622 Pathogenic MSH2 P43246 R55D 55 R D 0.056 Neutral MSH2 P43246 R55E 55 R E 0.044 Neutral MSH2 P43246 R55F 55 R F 0.862 Pathogenic MSH2 P43246 R55G 55 R G 0.194 Neutral MSH2 P43246 R55H 55 R H 0.538 Pathogenic MSH2 P43246 R55I 55 R I 0.88 Pathogenic MSH2 P43246 R55K 55 R K 0.052 Neutral MSH2 P43246 R55L 55 R L 0.238 Neutral MSH2 P43246 R55M 55 R M 0.378 Neutral MSH2 P43246 R55N 55 R N 0.018 Neutral MSH2 P43246 R55P 55 R P 0.798 Pathogenic MSH2 P43246 R55Q 55 R Q 0.02 Neutral MSH2 P43246 R55S 55 R S 0.038 Neutral MSH2 P43246 R55T 55 R T 0.042 Neutral MSH2 P43246 R55V 55 R V 0.786 Pathogenic MSH2 P43246 R55W 55 R W 0.86 Pathogenic MSH2 P43246 R55Y 55 R Y 0.826 Pathogenic MSH2 P43246 K550A 550 K A 0.266 Neutral MSH2 P43246 K550C 550 K C 0.21 Neutral MSH2 P43246 K550D 550 K D 0.34 Neutral MSH2 P43246 K550E 550 K E 0.402 Neutral MSH2 P43246 K550F 550 K F 0.122 Neutral MSH2 P43246 K550G 550 K G 0.354 Neutral MSH2 P43246 K550H 550 K H 0.016 Neutral MSH2 P43246 K550I 550 K I 0.396 Neutral MSH2 P43246 K550L 550 K L 0.15 Neutral MSH2 P43246 K550M 550 K M 0.596 Pathogenic MSH2 P43246 K550N 550 K N 0.39 Neutral MSH2 P43246 K550P 550 K P 0.766 Pathogenic MSH2 P43246 K550Q 550 K Q 0.168 Neutral MSH2 P43246 K550R 550 K R 0.042 Neutral MSH2 P43246 K550S 550 K S 0.338 Neutral MSH2 P43246 K550T 550 K T 0.25 Neutral MSH2 P43246 K550V 550 K V 0.704 Pathogenic MSH2 P43246 K550W 550 K W 0.94 Pathogenic MSH2 P43246 K550Y 550 K Y 0.338 Neutral MSH2 P43246 F551A 551 F A 0.4 Neutral MSH2 P43246 F551C 551 F C 0.734 Pathogenic MSH2 P43246 F551D 551 F D 0.826 Pathogenic MSH2 P43246 F551E 551 F E 0.878 Pathogenic MSH2 P43246 F551G 551 F G 0.508 Pathogenic MSH2 P43246 F551H 551 F H 0.786 Pathogenic MSH2 P43246 F551I 551 F I 0.694 Pathogenic MSH2 P43246 F551K 551 F K 0.858 Pathogenic MSH2 P43246 F551L 551 F L 0.708 Pathogenic MSH2 P43246 F551M 551 F M 0.8 Pathogenic MSH2 P43246 F551N 551 F N 0.774 Pathogenic MSH2 P43246 F551P 551 F P 0.954 Pathogenic MSH2 P43246 F551Q 551 F Q 0.794 Pathogenic MSH2 P43246 F551R 551 F R 0.922 Pathogenic MSH2 P43246 F551S 551 F S 0.882 Pathogenic MSH2 P43246 F551T 551 F T 0.61 Pathogenic MSH2 P43246 F551V 551 F V 0.766 Pathogenic MSH2 P43246 F551W 551 F W 0.874 Pathogenic MSH2 P43246 F551Y 551 F Y 0.588 Pathogenic MSH2 P43246 T552A 552 T A 0.176 Neutral MSH2 P43246 T552C 552 T C 0.886 Pathogenic MSH2 P43246 T552D 552 T D 0.9 Pathogenic MSH2 P43246 T552E 552 T E 0.94 Pathogenic MSH2 P43246 T552F 552 T F 0.936 Pathogenic MSH2 P43246 T552G 552 T G 0.654 Pathogenic MSH2 P43246 T552H 552 T H 0.532 Pathogenic MSH2 P43246 T552I 552 T I 0.622 Pathogenic MSH2 P43246 T552K 552 T K 0.912 Pathogenic MSH2 P43246 T552L 552 T L 0.918 Pathogenic MSH2 P43246 T552M 552 T M 0.738 Pathogenic MSH2 P43246 T552N 552 T N 0.188 Neutral MSH2 P43246 T552P 552 T P 0.944 Pathogenic MSH2 P43246 T552Q 552 T Q 0.218 Neutral MSH2 P43246 T552R 552 T R 0.532 Pathogenic MSH2 P43246 T552S 552 T S 0.132 Neutral MSH2 P43246 T552V 552 T V 0.382 Neutral MSH2 P43246 T552W 552 T W 0.994 Pathogenic MSH2 P43246 T552Y 552 T Y 0.922 Pathogenic MSH2 P43246 N553A 553 N A 0.674 Pathogenic MSH2 P43246 N553C 553 N C 0.762 Pathogenic MSH2 P43246 N553D 553 N D 0.626 Pathogenic MSH2 P43246 N553E 553 N E 0.704 Pathogenic MSH2 P43246 N553F 553 N F 0.96 Pathogenic MSH2 P43246 N553G 553 N G 0.858 Pathogenic MSH2 P43246 N553H 553 N H 0.928 Pathogenic MSH2 P43246 N553I 553 N I 0.842 Pathogenic MSH2 P43246 N553K 553 N K 0.966 Pathogenic MSH2 P43246 N553L 553 N L 0.948 Pathogenic MSH2 P43246 N553M 553 N M 0.952 Pathogenic MSH2 P43246 N553P 553 N P 0.866 Pathogenic MSH2 P43246 N553Q 553 N Q 0.936 Pathogenic MSH2 P43246 N553R 553 N R 0.694 Pathogenic MSH2 P43246 N553S 553 N S 0.194 Neutral MSH2 P43246 N553T 553 N T 0.318 Neutral MSH2 P43246 N553V 553 N V 0.774 Pathogenic MSH2 P43246 N553W 553 N W 0.972 Pathogenic MSH2 P43246 N553Y 553 N Y 0.966 Pathogenic MSH2 P43246 S554A 554 S A 0.062 Neutral MSH2 P43246 S554C 554 S C 0.482 Neutral MSH2 P43246 S554D 554 S D 0.076 Neutral MSH2 P43246 S554E 554 S E 0.456 Neutral MSH2 P43246 S554F 554 S F 0.892 Pathogenic MSH2 P43246 S554G 554 S G 0.042 Neutral MSH2 P43246 S554H 554 S H 0.674 Pathogenic MSH2 P43246 S554I 554 S I 0.466 Neutral MSH2 P43246 S554K 554 S K 0.446 Neutral MSH2 P43246 S554L 554 S L 0.636 Pathogenic MSH2 P43246 S554M 554 S M 0.98 Pathogenic MSH2 P43246 S554N 554 S N 0.05 Neutral MSH2 P43246 S554P 554 S P 0.184 Neutral MSH2 P43246 S554Q 554 S Q 0.498 Neutral MSH2 P43246 S554R 554 S R 0.48 Neutral MSH2 P43246 S554T 554 S T 0.048 Neutral MSH2 P43246 S554V 554 S V 0.426 Neutral MSH2 P43246 S554W 554 S W 0.952 Pathogenic MSH2 P43246 S554Y 554 S Y 0.934 Pathogenic MSH2 P43246 K555A 555 K A 0.068 Neutral MSH2 P43246 K555C 555 K C 0.198 Neutral MSH2 P43246 K555D 555 K D 0.022 Neutral MSH2 P43246 K555E 555 K E 0.02 Neutral MSH2 P43246 K555F 555 K F 0.846 Pathogenic MSH2 P43246 K555G 555 K G 0.148 Neutral MSH2 P43246 K555H 555 K H 0.03 Neutral MSH2 P43246 K555I 555 K I 0.74 Pathogenic MSH2 P43246 K555L 555 K L 0.676 Pathogenic MSH2 P43246 K555M 555 K M 0.656 Pathogenic MSH2 P43246 K555N 555 K N 0.03 Neutral MSH2 P43246 K555P 555 K P 0.086 Neutral MSH2 P43246 K555Q 555 K Q 0.038 Neutral MSH2 P43246 K555R 555 K R 0.036 Neutral MSH2 P43246 K555S 555 K S 0.032 Neutral MSH2 P43246 K555T 555 K T 0.032 Neutral MSH2 P43246 K555V 555 K V 0.372 Neutral MSH2 P43246 K555W 555 K W 0.98 Pathogenic MSH2 P43246 K555Y 555 K Y 0.932 Pathogenic MSH2 P43246 L556A 556 L A 0.716 Pathogenic MSH2 P43246 L556C 556 L C 0.822 Pathogenic MSH2 P43246 L556D 556 L D 0.908 Pathogenic MSH2 P43246 L556E 556 L E 0.892 Pathogenic MSH2 P43246 L556F 556 L F 0.87 Pathogenic MSH2 P43246 L556G 556 L G 0.87 Pathogenic MSH2 P43246 L556H 556 L H 0.91 Pathogenic MSH2 P43246 L556I 556 L I 0.444 Neutral MSH2 P43246 L556K 556 L K 0.722 Pathogenic MSH2 P43246 L556M 556 L M 0.322 Neutral MSH2 P43246 L556N 556 L N 0.818 Pathogenic MSH2 P43246 L556P 556 L P 0.988 Pathogenic MSH2 P43246 L556Q 556 L Q 0.774 Pathogenic MSH2 P43246 L556R 556 L R 0.774 Pathogenic MSH2 P43246 L556S 556 L S 0.706 Pathogenic MSH2 P43246 L556T 556 L T 0.624 Pathogenic MSH2 P43246 L556V 556 L V 0.266 Neutral MSH2 P43246 L556W 556 L W 0.874 Pathogenic MSH2 P43246 L556Y 556 L Y 0.886 Pathogenic MSH2 P43246 T557A 557 T A 0.06 Neutral MSH2 P43246 T557C 557 T C 0.496 Neutral MSH2 P43246 T557D 557 T D 0.296 Neutral MSH2 P43246 T557E 557 T E 0.144 Neutral MSH2 P43246 T557F 557 T F 0.752 Pathogenic MSH2 P43246 T557G 557 T G 0.278 Neutral MSH2 P43246 T557H 557 T H 0.374 Neutral MSH2 P43246 T557I 557 T I 0.548 Pathogenic MSH2 P43246 T557K 557 T K 0.094 Neutral MSH2 P43246 T557L 557 T L 0.28 Neutral MSH2 P43246 T557M 557 T M 0.536 Pathogenic MSH2 P43246 T557N 557 T N 0.014 Neutral MSH2 P43246 T557P 557 T P 0.638 Pathogenic MSH2 P43246 T557Q 557 T Q 0.036 Neutral MSH2 P43246 T557R 557 T R 0.472 Neutral MSH2 P43246 T557S 557 T S 0.008 Neutral MSH2 P43246 T557V 557 T V 0.742 Pathogenic MSH2 P43246 T557W 557 T W 0.922 Pathogenic MSH2 P43246 T557Y 557 T Y 0.942 Pathogenic MSH2 P43246 S558A 558 S A 0.066 Neutral MSH2 P43246 S558C 558 S C 0.456 Neutral MSH2 P43246 S558D 558 S D 0.092 Neutral MSH2 P43246 S558E 558 S E 0.456 Neutral MSH2 P43246 S558F 558 S F 0.88 Pathogenic MSH2 P43246 S558G 558 S G 0.044 Neutral MSH2 P43246 S558H 558 S H 0.796 Pathogenic MSH2 P43246 S558I 558 S I 0.584 Pathogenic MSH2 P43246 S558K 558 S K 0.454 Neutral MSH2 P43246 S558L 558 S L 0.538 Pathogenic MSH2 P43246 S558M 558 S M 0.976 Pathogenic MSH2 P43246 S558N 558 S N 0.08 Neutral MSH2 P43246 S558P 558 S P 0.508 Pathogenic MSH2 P43246 S558Q 558 S Q 0.48 Neutral MSH2 P43246 S558R 558 S R 0.494 Neutral MSH2 P43246 S558T 558 S T 0.086 Neutral MSH2 P43246 S558V 558 S V 0.796 Pathogenic MSH2 P43246 S558W 558 S W 0.952 Pathogenic MSH2 P43246 S558Y 558 S Y 0.932 Pathogenic MSH2 P43246 L559A 559 L A 0.118 Neutral MSH2 P43246 L559C 559 L C 0.282 Neutral MSH2 P43246 L559D 559 L D 0.89 Pathogenic MSH2 P43246 L559E 559 L E 0.51 Pathogenic MSH2 P43246 L559F 559 L F 0.476 Neutral MSH2 P43246 L559G 559 L G 0.792 Pathogenic MSH2 P43246 L559H 559 L H 0.214 Neutral MSH2 P43246 L559I 559 L I 0.182 Neutral MSH2 P43246 L559K 559 L K 0.17 Neutral MSH2 P43246 L559M 559 L M 0.196 Neutral MSH2 P43246 L559N 559 L N 0.756 Pathogenic MSH2 P43246 L559P 559 L P 0.994 Pathogenic MSH2 P43246 L559Q 559 L Q 0.624 Pathogenic MSH2 P43246 L559R 559 L R 0.988 Pathogenic MSH2 P43246 L559S 559 L S 0.602 Pathogenic MSH2 P43246 L559T 559 L T 0.576 Pathogenic MSH2 P43246 L559V 559 L V 0.096 Neutral MSH2 P43246 L559W 559 L W 0.94 Pathogenic MSH2 P43246 L559Y 559 L Y 0.63 Pathogenic MSH2 P43246 E56A 56 E A 0.188 Neutral MSH2 P43246 E56C 56 E C 0.386 Neutral MSH2 P43246 E56D 56 E D 0.034 Neutral MSH2 P43246 E56F 56 E F 0.782 Pathogenic MSH2 P43246 E56G 56 E G 0.218 Neutral MSH2 P43246 E56H 56 E H 0.034 Neutral MSH2 P43246 E56I 56 E I 0.85 Pathogenic MSH2 P43246 E56K 56 E K 0.028 Neutral MSH2 P43246 E56L 56 E L 0.12 Neutral MSH2 P43246 E56M 56 E M 0.158 Neutral MSH2 P43246 E56N 56 E N 0.014 Neutral MSH2 P43246 E56P 56 E P 0.84 Pathogenic MSH2 P43246 E56Q 56 E Q 0.012 Neutral MSH2 P43246 E56R 56 E R 0.086 Neutral MSH2 P43246 E56S 56 E S 0.266 Neutral MSH2 P43246 E56T 56 E T 0.042 Neutral MSH2 P43246 E56V 56 E V 0.088 Neutral MSH2 P43246 E56W 56 E W 0.918 Pathogenic MSH2 P43246 E56Y 56 E Y 0.602 Pathogenic MSH2 P43246 N560A 560 N A 0.238 Neutral MSH2 P43246 N560C 560 N C 0.576 Pathogenic MSH2 P43246 N560D 560 N D 0.596 Pathogenic MSH2 P43246 N560E 560 N E 0.494 Neutral MSH2 P43246 N560F 560 N F 0.904 Pathogenic MSH2 P43246 N560G 560 N G 0.198 Neutral MSH2 P43246 N560H 560 N H 0.752 Pathogenic MSH2 P43246 N560I 560 N I 0.89 Pathogenic MSH2 P43246 N560K 560 N K 0.82 Pathogenic MSH2 P43246 N560L 560 N L 0.786 Pathogenic MSH2 P43246 N560M 560 N M 0.862 Pathogenic MSH2 P43246 N560P 560 N P 0.74 Pathogenic MSH2 P43246 N560Q 560 N Q 0.716 Pathogenic MSH2 P43246 N560R 560 N R 0.532 Pathogenic MSH2 P43246 N560S 560 N S 0.204 Neutral MSH2 P43246 N560T 560 N T 0.518 Pathogenic MSH2 P43246 N560V 560 N V 0.924 Pathogenic MSH2 P43246 N560W 560 N W 0.914 Pathogenic MSH2 P43246 N560Y 560 N Y 0.906 Pathogenic MSH2 P43246 E561A 561 E A 0.45 Neutral MSH2 P43246 E561C 561 E C 0.494 Neutral MSH2 P43246 E561D 561 E D 0.018 Neutral MSH2 P43246 E561F 561 E F 0.888 Pathogenic MSH2 P43246 E561G 561 E G 0.03 Neutral MSH2 P43246 E561H 561 E H 0.608 Pathogenic MSH2 P43246 E561I 561 E I 0.942 Pathogenic MSH2 P43246 E561K 561 E K 0.642 Pathogenic MSH2 P43246 E561L 561 E L 0.772 Pathogenic MSH2 P43246 E561M 561 E M 0.638 Pathogenic MSH2 P43246 E561N 561 E N 0.014 Neutral MSH2 P43246 E561P 561 E P 0.888 Pathogenic MSH2 P43246 E561Q 561 E Q 0.016 Neutral MSH2 P43246 E561R 561 E R 0.134 Neutral MSH2 P43246 E561S 561 E S 0.042 Neutral MSH2 P43246 E561T 561 E T 0.044 Neutral MSH2 P43246 E561V 561 E V 0.412 Neutral MSH2 P43246 E561W 561 E W 0.964 Pathogenic MSH2 P43246 E561Y 561 E Y 0.922 Pathogenic MSH2 P43246 E562A 562 E A 0.254 Neutral MSH2 P43246 E562C 562 E C 0.638 Pathogenic MSH2 P43246 E562D 562 E D 0.094 Neutral MSH2 P43246 E562F 562 E F 0.942 Pathogenic MSH2 P43246 E562G 562 E G 0.092 Neutral MSH2 P43246 E562H 562 E H 0.662 Pathogenic MSH2 P43246 E562I 562 E I 0.974 Pathogenic MSH2 P43246 E562K 562 E K 0.332 Neutral MSH2 P43246 E562L 562 E L 0.488 Neutral MSH2 P43246 E562M 562 E M 0.86 Pathogenic MSH2 P43246 E562N 562 E N 0.098 Neutral MSH2 P43246 E562P 562 E P 0.922 Pathogenic MSH2 P43246 E562Q 562 E Q 0.074 Neutral MSH2 P43246 E562R 562 E R 0.322 Neutral MSH2 P43246 E562S 562 E S 0.156 Neutral MSH2 P43246 E562T 562 E T 0.188 Neutral MSH2 P43246 E562V 562 E V 0.662 Pathogenic MSH2 P43246 E562W 562 E W 0.98 Pathogenic MSH2 P43246 E562Y 562 E Y 0.96 Pathogenic MSH2 P43246 Y563A 563 Y A 0.338 Neutral MSH2 P43246 Y563C 563 Y C 0.284 Neutral MSH2 P43246 Y563D 563 Y D 0.792 Pathogenic MSH2 P43246 Y563E 563 Y E 0.724 Pathogenic MSH2 P43246 Y563F 563 Y F 0.05 Neutral MSH2 P43246 Y563G 563 Y G 0.388 Neutral MSH2 P43246 Y563H 563 Y H 0.09 Neutral MSH2 P43246 Y563I 563 Y I 0.256 Neutral MSH2 P43246 Y563K 563 Y K 0.82 Pathogenic MSH2 P43246 Y563L 563 Y L 0.13 Neutral MSH2 P43246 Y563M 563 Y M 0.602 Pathogenic MSH2 P43246 Y563N 563 Y N 0.624 Pathogenic MSH2 P43246 Y563P 563 Y P 0.698 Pathogenic MSH2 P43246 Y563Q 563 Y Q 0.296 Neutral MSH2 P43246 Y563R 563 Y R 0.174 Neutral MSH2 P43246 Y563S 563 Y S 0.228 Neutral MSH2 P43246 Y563T 563 Y T 0.164 Neutral MSH2 P43246 Y563V 563 Y V 0.38 Neutral MSH2 P43246 Y563W 563 Y W 0.786 Pathogenic MSH2 P43246 T564A 564 T A 0.018 Neutral 1 MSH2 P43246 T564C 564 T C 0.322 Neutral MSH2 P43246 T564D 564 T D 0.072 Neutral MSH2 P43246 T564E 564 T E 0.444 Neutral MSH2 P43246 T564F 564 T F 0.596 Pathogenic MSH2 P43246 T564G 564 T G 0.092 Neutral MSH2 P43246 T564H 564 T H 0.414 Neutral MSH2 P43246 T564I 564 T I 0.074 Neutral MSH2 P43246 T564K 564 T K 0.044 Neutral MSH2 P43246 T564L 564 T L 0.036 Neutral MSH2 P43246 T564M 564 T M 0.104 Neutral MSH2 P43246 T564N 564 T N 0.222 Neutral MSH2 P43246 T564P 564 T P 0.524 Pathogenic MSH2 P43246 T564Q 564 T Q 0.028 Neutral MSH2 P43246 T564R 564 T R 0.4 Neutral MSH2 P43246 T564S 564 T S 0.022 Neutral MSH2 P43246 T564V 564 T V 0.046 Neutral MSH2 P43246 T564W 564 T W 0.886 Pathogenic MSH2 P43246 T564Y 564 T Y 0.874 Pathogenic MSH2 P43246 K565A 565 K A 0.1 Neutral MSH2 P43246 K565C 565 K C 0.18 Neutral MSH2 P43246 K565D 565 K D 0.032 Neutral MSH2 P43246 K565E 565 K E 0.034 Neutral MSH2 P43246 K565F 565 K F 0.804 Pathogenic MSH2 P43246 K565G 565 K G 0.108 Neutral MSH2 P43246 K565H 565 K H 0.332 Neutral MSH2 P43246 K565I 565 K I 0.762 Pathogenic MSH2 P43246 K565L 565 K L 0.448 Neutral MSH2 P43246 K565M 565 K M 0.608 Pathogenic MSH2 P43246 K565N 565 K N 0.16 Neutral MSH2 P43246 K565P 565 K P 0.8 Pathogenic MSH2 P43246 K565Q 565 K Q 0.042 Neutral MSH2 P43246 K565R 565 K R 0.046 Neutral MSH2 P43246 K565S 565 K S 0.04 Neutral MSH2 P43246 K565T 565 K T 0.054 Neutral MSH2 P43246 K565V 565 K V 0.146 Neutral MSH2 P43246 K565W 565 K W 0.976 Pathogenic MSH2 P43246 K565Y 565 K Y 0.92 Pathogenic MSH2 P43246 N566A 566 N A 0.064 Neutral MSH2 P43246 N566C 566 N C 0.06 Neutral MSH2 P43246 N566D 566 N D 0.59 Pathogenic MSH2 P43246 N566E 566 N E 0.534 Pathogenic MSH2 P43246 N566F 566 N F 0.652 Pathogenic MSH2 P43246 N566G 566 N G 0.614 Pathogenic MSH2 P43246 N566H 566 N H 0.758 Pathogenic MSH2 P43246 N566I 566 N I 0.324 Neutral MSH2 P43246 N566K 566 N K 0.81 Pathogenic MSH2 P43246 N566L 566 N L 0.274 Neutral MSH2 P43246 N566M 566 N M 0.43 Neutral MSH2 P43246 N566P 566 N P 0.758 Pathogenic MSH2 P43246 N566Q 566 N Q 0.068 Neutral MSH2 P43246 N566R 566 N R 0.728 Pathogenic MSH2 P43246 N566S 566 N S 0.04 Neutral MSH2 P43246 N566T 566 N T 0.056 Neutral MSH2 P43246 N566V 566 N V 0.106 Neutral MSH2 P43246 N566W 566 N W 0.944 Pathogenic MSH2 P43246 N566Y 566 N Y 0.714 Pathogenic MSH2 P43246 K567A 567 K A 0.166 Neutral MSH2 P43246 K567C 567 K C 0.172 Neutral MSH2 P43246 K567D 567 K D 0.08 Neutral MSH2 P43246 K567E 567 K E 0.182 Neutral MSH2 P43246 K567F 567 K F 0.8 Pathogenic MSH2 P43246 K567G 567 K G 0.33 Neutral MSH2 P43246 K567H 567 K H 0.04 Neutral MSH2 P43246 K567I 567 K I 0.778 Pathogenic MSH2 P43246 K567L 567 K L 0.126 Neutral MSH2 P43246 K567M 567 K M 0.316 Neutral MSH2 P43246 K567N 567 K N 0.09 Neutral MSH2 P43246 K567P 567 K P 0.802 Pathogenic MSH2 P43246 K567Q 567 K Q 0.052 Neutral MSH2 P43246 K567R 567 K R 0.048 Neutral MSH2 P43246 K567S 567 K S 0.05 Neutral MSH2 P43246 K567T 567 K T 0.052 Neutral MSH2 P43246 K567V 567 K V 0.16 Neutral MSH2 P43246 K567W 567 K W 0.972 Pathogenic MSH2 P43246 K567Y 567 K Y 0.456 Neutral MSH2 P43246 T568A 568 T A 0.07 Neutral MSH2 P43246 T568C 568 T C 0.456 Neutral MSH2 P43246 T568D 568 T D 0.106 Neutral MSH2 P43246 T568E 568 T E 0.156 Neutral MSH2 P43246 T568F 568 T F 0.698 Pathogenic MSH2 P43246 T568G 568 T G 0.048 Neutral MSH2 P43246 T568H 568 T H 0.46 Neutral MSH2 P43246 T568I 568 T I 0.462 Neutral MSH2 P43246 T568K 568 T K 0.094 Neutral MSH2 P43246 T568L 568 T L 0.446 Neutral MSH2 P43246 T568M 568 T M 0.532 Pathogenic MSH2 P43246 T568N 568 T N 0.022 Neutral MSH2 P43246 T568P 568 T P 0.604 Pathogenic MSH2 P43246 T568Q 568 T Q 0.028 Neutral MSH2 P43246 T568R 568 T R 0.46 Neutral MSH2 P43246 T568S 568 T S 0.024 Neutral MSH2 P43246 T568V 568 T V 0.736 Pathogenic MSH2 P43246 T568W 568 T W 0.914 Pathogenic MSH2 P43246 T568Y 568 T Y 0.894 Pathogenic MSH2 P43246 E569A 569 E A 0.24 Neutral MSH2 P43246 E569C 569 E C 0.454 Neutral MSH2 P43246 E569D 569 E D 0.034 Neutral MSH2 P43246 E569F 569 E F 0.834 Pathogenic MSH2 P43246 E569G 569 E G 0.174 Neutral MSH2 P43246 E569H 569 E H 0.592 Pathogenic MSH2 P43246 E569I 569 E I 0.86 Pathogenic MSH2 P43246 E569K 569 E K 0.044 Neutral MSH2 P43246 E569L 569 E L 0.166 Neutral MSH2 P43246 E569M 569 E M 0.182 Neutral MSH2 P43246 E569N 569 E N 0.024 Neutral MSH2 P43246 E569P 569 E P 0.862 Pathogenic MSH2 P43246 E569Q 569 E Q 0.024 Neutral MSH2 P43246 E569R 569 E R 0.128 Neutral MSH2 P43246 E569S 569 E S 0.05 Neutral MSH2 P43246 E569T 569 E T 0.058 Neutral MSH2 P43246 E569V 569 E V 0.744 Pathogenic MSH2 P43246 E569W 569 E W 0.968 Pathogenic MSH2 P43246 E569Y 569 E Y 0.906 Pathogenic MSH2 P43246 V57A 57 V A 0.146 Neutral MSH2 P43246 V57C 57 V C 0.34 Neutral MSH2 P43246 V57D 57 V D 0.854 Pathogenic MSH2 P43246 V57E 57 V E 0.958 Pathogenic MSH2 P43246 V57F 57 V F 0.52 Pathogenic MSH2 P43246 V57G 57 V G 0.914 Pathogenic MSH2 P43246 V57H 57 V H 0.278 Neutral MSH2 P43246 V57I 57 V I 0.164 Neutral MSH2 P43246 V57K 57 V K 0.934 Pathogenic MSH2 P43246 V57L 57 V L 0.218 Neutral MSH2 P43246 V57M 57 V M 0.742 Pathogenic MSH2 P43246 V57N 57 V N 0.924 Pathogenic MSH2 P43246 V57P 57 V P 0.942 Pathogenic MSH2 P43246 V57Q 57 V Q 0.264 Neutral MSH2 P43246 V57R 57 V R 0.95 Pathogenic MSH2 P43246 V57S 57 V S 0.71 Pathogenic MSH2 P43246 V57T 57 V T 0.28 Neutral MSH2 P43246 V57W 57 V W 0.876 Pathogenic MSH2 P43246 V57Y 57 V Y 0.53 Pathogenic MSH2 P43246 Y570A 570 Y A 0.446 Neutral MSH2 P43246 Y570C 570 Y C 0.698 Pathogenic MSH2 P43246 Y570D 570 Y D 0.854 Pathogenic MSH2 P43246 Y570E 570 Y E 0.772 Pathogenic MSH2 P43246 Y570F 570 Y F 0.526 Pathogenic MSH2 P43246 Y570G 570 Y G 0.49 Neutral MSH2 P43246 Y570H 570 Y H 0.63 Pathogenic MSH2 P43246 Y570I 570 Y I 0.808 Pathogenic MSH2 P43246 Y570K 570 Y K 0.838 Pathogenic MSH2 P43246 Y570L 570 Y L 0.73 Pathogenic MSH2 P43246 Y570M 570 Y M 0.708 Pathogenic MSH2 P43246 Y570N 570 Y N 0.752 Pathogenic MSH2 P43246 Y570P 570 Y P 0.8 Pathogenic MSH2 P43246 Y570Q 570 Y Q 0.68 Pathogenic MSH2 P43246 Y570R 570 Y R 0.8 Pathogenic MSH2 P43246 Y570S 570 Y S 0.49 Neutral MSH2 P43246 Y570T 570 Y T 0.694 Pathogenic MSH2 P43246 Y570V 570 Y V 0.686 Pathogenic MSH2 P43246 Y570W 570 Y W 0.914 Pathogenic MSH2 P43246 E571A 571 E A 0.246 Neutral MSH2 P43246 E571C 571 E C 0.48 Neutral MSH2 P43246 E571D 571 E D 0.02 Neutral MSH2 P43246 E571F 571 E F 0.882 Pathogenic MSH2 P43246 E571G 571 E G 0.1 Neutral MSH2 P43246 E571H 571 E H 0.622 Pathogenic MSH2 P43246 E571I 571 E I 0.862 Pathogenic MSH2 P43246 E571K 571 E K 0.04 Neutral MSH2 P43246 E571L 571 E L 0.162 Neutral MSH2 P43246 E571M 571 E M 0.18 Neutral MSH2 P43246 E571N 571 E N 0.012 Neutral MSH2 P43246 E571P 571 E P 0.89 Pathogenic MSH2 P43246 E571Q 571 E Q 0.018 Neutral MSH2 P43246 E571R 571 E R 0.41 Neutral MSH2 P43246 E571S 571 E S 0.048 Neutral MSH2 P43246 E571T 571 E T 0.052 Neutral MSH2 P43246 E571V 571 E V 0.442 Neutral MSH2 P43246 E571W 571 E W 0.97 Pathogenic MSH2 P43246 E571Y 571 E Y 0.92 Pathogenic MSH2 P43246 E572A 572 E A 0.21 Neutral MSH2 P43246 E572C 572 E C 0.494 Neutral MSH2 P43246 E572D 572 E D 0.014 Neutral MSH2 P43246 E572F 572 E F 0.876 Pathogenic MSH2 P43246 E572G 572 E G 0.16 Neutral MSH2 P43246 E572H 572 E H 0.608 Pathogenic MSH2 P43246 E572I 572 E I 0.938 Pathogenic MSH2 P43246 E572K 572 E K 0.028 Neutral MSH2 P43246 E572L 572 E L 0.776 Pathogenic MSH2 P43246 E572M 572 E M 0.634 Pathogenic MSH2 P43246 E572N 572 E N 0.014 Neutral MSH2 P43246 E572P 572 E P 0.888 Pathogenic MSH2 P43246 E572Q 572 E Q 0.012 Neutral MSH2 P43246 E572R 572 E R 0.116 Neutral MSH2 P43246 E572S 572 E S 0.042 Neutral MSH2 P43246 E572T 572 E T 0.492 Neutral MSH2 P43246 E572V 572 E V 0.406 Neutral MSH2 P43246 E572W 572 E W 0.964 Pathogenic MSH2 P43246 E572Y 572 E Y 0.884 Pathogenic MSH2 P43246 A573C 573 A C 0.182 Neutral MSH2 P43246 A573D 573 A D 0.856 Pathogenic MSH2 P43246 A573E 573 A E 0.632 Pathogenic MSH2 P43246 A573F 573 A F 0.968 Pathogenic MSH2 P43246 A573G 573 A G 0.48 Neutral MSH2 P43246 A573H 573 A H 0.708 Pathogenic MSH2 P43246 A573I 573 A I 0.618 Pathogenic MSH2 P43246 A573K 573 A K 0.552 Pathogenic MSH2 P43246 A573L 573 A L 0.584 Pathogenic MSH2 P43246 A573M 573 A M 0.604 Pathogenic MSH2 P43246 A573N 573 A N 0.772 Pathogenic MSH2 P43246 A573P 573 A P 0.872 Pathogenic MSH2 P43246 A573Q 573 A Q 0.512 Pathogenic MSH2 P43246 A573R 573 A R 0.636 Pathogenic MSH2 P43246 A573S 573 A S 0.02 Neutral MSH2 P43246 A573T 573 A T 0.06 Neutral MSH2 P43246 A573V 573 A V 0.434 Neutral MSH2 P43246 A573W 573 A W 0.954 Pathogenic MSH2 P43246 A573Y 573 A Y 0.94 Pathogenic MSH2 P43246 Q574A 574 Q A 0.794 Pathogenic MSH2 P43246 Q574C 574 Q C 0.776 Pathogenic MSH2 P43246 Q574D 574 Q D 0.868 Pathogenic MSH2 P43246 Q574E 574 Q E 0.768 Pathogenic MSH2 P43246 Q574F 574 Q F 0.926 Pathogenic MSH2 P43246 Q574G 574 Q G 0.54 Pathogenic MSH2 P43246 Q574H 574 Q H 0.936 Pathogenic MSH2 P43246 Q574I 574 Q I 0.952 Pathogenic MSH2 P43246 Q574K 574 Q K 0.93 Pathogenic MSH2 P43246 Q574L 574 Q L 0.874 Pathogenic MSH2 P43246 Q574M 574 Q M 0.912 Pathogenic MSH2 P43246 Q574N 574 Q N 0.902 Pathogenic MSH2 P43246 Q574P 574 Q P 0.926 Pathogenic MSH2 P43246 Q574R 574 Q R 0.928 Pathogenic MSH2 P43246 Q574S 574 Q S 0.702 Pathogenic MSH2 P43246 Q574T 574 Q T 0.532 Pathogenic MSH2 P43246 Q574V 574 Q V 0.936 Pathogenic MSH2 P43246 Q574W 574 Q W 0.958 Pathogenic MSH2 P43246 Q574Y 574 Q Y 0.944 Pathogenic MSH2 P43246 D575A 575 D A 0.122 Neutral MSH2 P43246 D575C 575 D C 0.726 Pathogenic MSH2 P43246 D575E 575 D E 0.07 Neutral MSH2 P43246 D575F 575 D F 0.926 Pathogenic MSH2 P43246 D575G 575 D G 0.212 Neutral MSH2 P43246 D575H 575 D H 0.544 Pathogenic MSH2 P43246 D575I 575 D I 0.884 Pathogenic MSH2 P43246 D575K 575 D K 0.062 Neutral MSH2 P43246 D575L 575 D L 0.244 Neutral MSH2 P43246 D575M 575 D M 0.79 Pathogenic MSH2 P43246 D575N 575 D N 0.008 Neutral MSH2 P43246 D575P 575 D P 0.8 Pathogenic MSH2 P43246 D575Q 575 D Q 0.032 Neutral MSH2 P43246 D575R 575 D R 0.474 Neutral MSH2 P43246 D575S 575 D S 0.03 Neutral MSH2 P43246 D575T 575 D T 0.048 Neutral MSH2 P43246 D575V 575 D V 0.908 Pathogenic MSH2 P43246 D575W 575 D W 0.97 Pathogenic MSH2 P43246 D575Y 575 D Y 0.964 Pathogenic MSH2 P43246 A576C 576 A C 0.722 Pathogenic MSH2 P43246 A576D 576 A D 0.712 Pathogenic MSH2 P43246 A576E 576 A E 0.598 Pathogenic MSH2 P43246 A576F 576 A F 0.964 Pathogenic MSH2 P43246 A576G 576 A G 0.02 Neutral MSH2 P43246 A576H 576 A H 0.602 Pathogenic MSH2 P43246 A576I 576 A I 0.942 Pathogenic MSH2 P43246 A576K 576 A K 0.552 Pathogenic MSH2 P43246 A576L 576 A L 0.918 Pathogenic MSH2 P43246 A576M 576 A M 0.832 Pathogenic MSH2 P43246 A576N 576 A N 0.656 Pathogenic MSH2 P43246 A576P 576 A P 0.888 Pathogenic MSH2 P43246 A576Q 576 A Q 0.508 Pathogenic MSH2 P43246 A576R 576 A R 0.908 Pathogenic MSH2 P43246 A576S 576 A S 0.016 Neutral MSH2 P43246 A576T 576 A T 0.048 Neutral MSH2 P43246 A576V 576 A V 0.16 Neutral MSH2 P43246 A576W 576 A W 0.95 Pathogenic MSH2 P43246 A576Y 576 A Y 0.94 Pathogenic MSH2 P43246 I577A 577 I A 0.516 Pathogenic MSH2 P43246 I577C 577 I C 0.626 Pathogenic MSH2 P43246 I577D 577 I D 0.716 Pathogenic MSH2 P43246 I577E 577 I E 0.728 Pathogenic MSH2 P43246 I577F 577 I F 0.438 Neutral MSH2 P43246 I577G 577 I G 0.784 Pathogenic MSH2 P43246 I577H 577 I H 0.876 Pathogenic MSH2 P43246 I577K 577 I K 0.824 Pathogenic MSH2 P43246 I577L 577 I L 0.198 Neutral MSH2 P43246 I577M 577 I M 0.414 Neutral MSH2 P43246 I577N 577 I N 0.74 Pathogenic MSH2 P43246 I577P 577 I P 0.908 Pathogenic MSH2 P43246 I577Q 577 I Q 0.756 Pathogenic MSH2 P43246 I577R 577 I R 0.858 Pathogenic MSH2 P43246 I577S 577 I S 0.604 Pathogenic MSH2 P43246 I577T 577 I T 0.288 Neutral 2 MSH2 P43246 I577V 577 I V 0.108 Neutral MSH2 P43246 I577W 577 I W 0.976 Pathogenic MSH2 P43246 I577Y 577 I Y 0.962 Pathogenic MSH2 P43246 V578A 578 V A 0.33 Neutral MSH2 P43246 V578C 578 V C 0.812 Pathogenic MSH2 P43246 V578D 578 V D 0.87 Pathogenic MSH2 P43246 V578E 578 V E 0.964 Pathogenic MSH2 P43246 V578F 578 V F 0.932 Pathogenic MSH2 P43246 V578G 578 V G 0.922 Pathogenic MSH2 P43246 V578H 578 V H 0.914 Pathogenic MSH2 P43246 V578I 578 V I 0.422 Neutral MSH2 P43246 V578K 578 V K 0.984 Pathogenic MSH2 P43246 V578L 578 V L 0.676 Pathogenic MSH2 P43246 V578M 578 V M 0.92 Pathogenic MSH2 P43246 V578N 578 V N 0.926 Pathogenic MSH2 P43246 V578P 578 V P 0.992 Pathogenic MSH2 P43246 V578Q 578 V Q 0.97 Pathogenic MSH2 P43246 V578R 578 V R 0.954 Pathogenic MSH2 P43246 V578S 578 V S 0.568 Pathogenic MSH2 P43246 V578T 578 V T 0.882 Pathogenic MSH2 P43246 V578W 578 V W 0.956 Pathogenic MSH2 P43246 V578Y 578 V Y 0.976 Pathogenic MSH2 P43246 K579A 579 K A 0.07 Neutral MSH2 P43246 K579C 579 K C 0.16 Neutral MSH2 P43246 K579D 579 K D 0.012 Neutral MSH2 P43246 K579E 579 K E 0.016 Neutral MSH2 P43246 K579F 579 K F 0.816 Pathogenic MSH2 P43246 K579G 579 K G 0.242 Neutral MSH2 P43246 K579H 579 K H 0.014 Neutral MSH2 P43246 K579I 579 K I 0.856 Pathogenic MSH2 P43246 K579L 579 K L 0.684 Pathogenic MSH2 P43246 K579M 579 K M 0.274 Neutral MSH2 P43246 K579N 579 K N 0.018 Neutral MSH2 P43246 K579P 579 K P 0.806 Pathogenic MSH2 P43246 K579Q 579 K Q 0.028 Neutral MSH2 P43246 K579R 579 K R 0.028 Neutral MSH2 P43246 K579S 579 K S 0.03 Neutral MSH2 P43246 K579T 579 K T 0.046 Neutral MSH2 P43246 K579V 579 K V 0.112 Neutral MSH2 P43246 K579W 579 K W 0.976 Pathogenic MSH2 P43246 K579Y 579 K Y 0.922 Pathogenic MSH2 P43246 F58A 58 F A 0.472 Neutral MSH2 P43246 F58C 58 F C 0.646 Pathogenic MSH2 P43246 F58D 58 F D 0.754 Pathogenic MSH2 P43246 F58E 58 F E 0.824 Pathogenic MSH2 P43246 F58G 58 F G 0.476 Neutral MSH2 P43246 F58H 58 F H 0.694 Pathogenic MSH2 P43246 F58I 58 F I 0.602 Pathogenic MSH2 P43246 F58K 58 F K 0.806 Pathogenic MSH2 P43246 F58L 58 F L 0.174 Neutral MSH2 P43246 F58M 58 F M 0.72 Pathogenic MSH2 P43246 F58N 58 F N 0.672 Pathogenic MSH2 P43246 F58P 58 F P 0.932 Pathogenic MSH2 P43246 F58Q 58 F Q 0.7 Pathogenic MSH2 P43246 F58R 58 F R 0.892 Pathogenic MSH2 P43246 F58S 58 F S 0.766 Pathogenic MSH2 P43246 F58T 58 F T 0.558 Pathogenic MSH2 P43246 F58V 58 F V 0.822 Pathogenic MSH2 P43246 F58W 58 F W 0.934 Pathogenic MSH2 P43246 F58Y 58 F Y 0.358 Neutral MSH2 P43246 E580A 580 E A 0.474 Neutral MSH2 P43246 E580C 580 E C 0.738 Pathogenic MSH2 P43246 E580D 580 E D 0.24 Neutral MSH2 P43246 E580F 580 E F 0.944 Pathogenic MSH2 P43246 E580G 580 E G 0.144 Neutral MSH2 P43246 E580H 580 E H 0.684 Pathogenic MSH2 P43246 E580I 580 E I 0.972 Pathogenic MSH2 P43246 E580K 580 E K 0.324 Neutral MSH2 P43246 E580L 580 E L 0.956 Pathogenic MSH2 P43246 E580M 580 E M 0.886 Pathogenic MSH2 P43246 E580N 580 E N 0.332 Neutral MSH2 P43246 E580P 580 E P 0.924 Pathogenic MSH2 P43246 E580Q 580 E Q 0.248 Neutral MSH2 P43246 E580R 580 E R 0.352 Neutral MSH2 P43246 E580S 580 E S 0.316 Neutral MSH2 P43246 E580T 580 E T 0.81 Pathogenic MSH2 P43246 E580V 580 E V 0.908 Pathogenic MSH2 P43246 E580W 580 E W 0.974 Pathogenic MSH2 P43246 E580Y 580 E Y 0.95 Pathogenic MSH2 P43246 I581A 581 I A 0.294 Neutral MSH2 P43246 I581C 581 I C 0.688 Pathogenic MSH2 P43246 I581D 581 I D 0.756 Pathogenic MSH2 P43246 I581E 581 I E 0.756 Pathogenic MSH2 P43246 I581F 581 I F 0.916 Pathogenic MSH2 P43246 I581G 581 I G 0.828 Pathogenic MSH2 P43246 I581H 581 I H 0.902 Pathogenic MSH2 P43246 I581K 581 I K 0.848 Pathogenic MSH2 P43246 I581L 581 I L 0.152 Neutral MSH2 P43246 I581M 581 I M 0.362 Neutral MSH2 P43246 I581N 581 I N 0.776 Pathogenic MSH2 P43246 I581P 581 I P 0.934 Pathogenic MSH2 P43246 I581Q 581 I Q 0.786 Pathogenic MSH2 P43246 I581R 581 I R 0.864 Pathogenic MSH2 P43246 I581S 581 I S 0.658 Pathogenic MSH2 P43246 I581T 581 I T 0.146 Neutral MSH2 P43246 I581V 581 I V 0.222 Neutral MSH2 P43246 I581W 581 I W 0.962 Pathogenic MSH2 P43246 I581Y 581 I Y 0.938 Pathogenic MSH2 P43246 V582A 582 V A 0.17 Neutral MSH2 P43246 V582C 582 V C 0.776 Pathogenic MSH2 P43246 V582D 582 V D 0.85 Pathogenic MSH2 P43246 V582E 582 V E 0.964 Pathogenic MSH2 P43246 V582F 582 V F 0.68 Pathogenic MSH2 P43246 V582G 582 V G 0.898 Pathogenic MSH2 P43246 V582H 582 V H 0.866 Pathogenic MSH2 P43246 V582I 582 V I 0.196 Neutral MSH2 P43246 V582K 582 V K 0.988 Pathogenic MSH2 P43246 V582L 582 V L 0.3 Neutral MSH2 P43246 V582M 582 V M 0.274 Neutral MSH2 P43246 V582N 582 V N 0.916 Pathogenic MSH2 P43246 V582P 582 V P 0.984 Pathogenic MSH2 P43246 V582Q 582 V Q 0.972 Pathogenic MSH2 P43246 V582R 582 V R 0.948 Pathogenic MSH2 P43246 V582S 582 V S 0.776 Pathogenic MSH2 P43246 V582T 582 V T 0.236 Neutral MSH2 P43246 V582W 582 V W 0.93 Pathogenic MSH2 P43246 V582Y 582 V Y 0.956 Pathogenic MSH2 P43246 N583A 583 N A 0.08 Neutral MSH2 P43246 N583C 583 N C 0.59 Pathogenic MSH2 P43246 N583D 583 N D 0.048 Neutral MSH2 P43246 N583E 583 N E 0.046 Neutral MSH2 P43246 N583F 583 N F 0.91 Pathogenic MSH2 P43246 N583G 583 N G 0.064 Neutral MSH2 P43246 N583H 583 N H 0.748 Pathogenic MSH2 P43246 N583I 583 N I 0.87 Pathogenic MSH2 P43246 N583K 583 N K 0.098 Neutral MSH2 P43246 N583L 583 N L 0.868 Pathogenic MSH2 P43246 N583M 583 N M 0.836 Pathogenic MSH2 P43246 N583P 583 N P 0.758 Pathogenic MSH2 P43246 N583Q 583 N Q 0.03 Neutral MSH2 P43246 N583R 583 N R 0.47 Neutral MSH2 P43246 N583S 583 N S 0.032 Neutral MSH2 P43246 N583T 583 N T 0.05 Neutral MSH2 P43246 N583V 583 N V 0.906 Pathogenic MSH2 P43246 N583W 583 N W 0.954 Pathogenic MSH2 P43246 N583Y 583 N Y 0.946 Pathogenic MSH2 P43246 I584A 584 I A 0.562 Pathogenic MSH2 P43246 I584C 584 I C 0.368 Neutral MSH2 P43246 I584D 584 I D 0.748 Pathogenic MSH2 P43246 I584E 584 I E 0.75 Pathogenic MSH2 P43246 I584F 584 I F 0.948 Pathogenic MSH2 P43246 I584G 584 I G 0.814 Pathogenic MSH2 P43246 I584H 584 I H 0.898 Pathogenic MSH2 P43246 I584K 584 I K 0.846 Pathogenic MSH2 P43246 I584L 584 I L 0.18 Neutral MSH2 P43246 I584M 584 I M 0.71 Pathogenic MSH2 P43246 I584N 584 I N 0.77 Pathogenic MSH2 P43246 I584P 584 I P 0.924 Pathogenic MSH2 P43246 I584Q 584 I Q 0.782 Pathogenic MSH2 P43246 I584R 584 I R 0.864 Pathogenic MSH2 P43246 I584S 584 I S 0.652 Pathogenic MSH2 P43246 I584T 584 I T 0.076 Neutral MSH2 P43246 I584V 584 I V 0.164 Neutral MSH2 P43246 I584W 584 I W 0.99 Pathogenic MSH2 P43246 I584Y 584 I Y 0.978 Pathogenic MSH2 P43246 S585A 585 S A 0.218 Neutral MSH2 P43246 S585C 585 S C 0.896 Pathogenic MSH2 P43246 S585D 585 S D 0.898 Pathogenic MSH2 P43246 S585E 585 S E 0.954 Pathogenic MSH2 P43246 S585F 585 S F 0.982 Pathogenic MSH2 P43246 S585G 585 S G 0.678 Pathogenic MSH2 P43246 S585H 585 S H 0.972 Pathogenic MSH2 P43246 S585I 585 S I 0.778 Pathogenic MSH2 P43246 S585K 585 S K 0.952 Pathogenic MSH2 P43246 S585L 585 S L 0.736 Pathogenic MSH2 P43246 S585M 585 S M 0.998 Pathogenic MSH2 P43246 S585N 585 S N 0.88 Pathogenic MSH2 P43246 S585P 585 S P 0.968 Pathogenic MSH2 P43246 S585Q 585 S Q 0.942 Pathogenic MSH2 P43246 S585R 585 S R 0.97 Pathogenic MSH2 P43246 S585T 585 S T 0.262 Neutral MSH2 P43246 S585V 585 S V 0.362 Neutral MSH2 P43246 S585W 585 S W 0.97 Pathogenic MSH2 P43246 S585Y 585 S Y 0.974 Pathogenic MSH2 P43246 S586A 586 S A 0.172 Neutral MSH2 P43246 S586C 586 S C 0.262 Neutral MSH2 P43246 S586D 586 S D 0.794 Pathogenic MSH2 P43246 S586E 586 S E 0.906 Pathogenic MSH2 P43246 S586F 586 S F 0.978 Pathogenic MSH2 P43246 S586G 586 S G 0.086 Neutral MSH2 P43246 S586H 586 S H 0.92 Pathogenic MSH2 P43246 S586I 586 S I 0.668 Pathogenic MSH2 P43246 S586K 586 S K 0.894 Pathogenic MSH2 P43246 S586L 586 S L 0.49 Neutral MSH2 P43246 S586M 586 S M 0.87 Pathogenic MSH2 P43246 S586N 586 S N 0.292 Neutral MSH2 P43246 S586P 586 S P 0.908 Pathogenic MSH2 P43246 S586Q 586 S Q 0.588 Pathogenic MSH2 P43246 S586R 586 S R 0.928 Pathogenic MSH2 P43246 S586T 586 S T 0.326 Neutral MSH2 P43246 S586V 586 S V 0.338 Neutral MSH2 P43246 S586W 586 S W 0.968 Pathogenic MSH2 P43246 S586Y 586 S Y 0.966 Pathogenic MSH2 P43246 G587A 587 G A 0.934 Pathogenic MSH2 P43246 G587C 587 G C 0.94 Pathogenic MSH2 P43246 G587D 587 G D 0.974 Pathogenic MSH2 P43246 G587E 587 G E 0.984 Pathogenic MSH2 P43246 G587F 587 G F 0.988 Pathogenic MSH2 P43246 G587H 587 G H 0.992 Pathogenic MSH2 P43246 G587I 587 G I 0.978 Pathogenic MSH2 P43246 G587K 587 G K 0.992 Pathogenic MSH2 P43246 G587L 587 G L 0.988 Pathogenic MSH2 P43246 G587M 587 G M 0.994 Pathogenic MSH2 P43246 G587N 587 G N 0.948 Pathogenic MSH2 P43246 G587P 587 G P 0.982 Pathogenic MSH2 P43246 G587Q 587 G Q 0.988 Pathogenic MSH2 P43246 G587R 587 G R 1 Pathogenic MSH2 P43246 G587S 587 G S 0.342 Neutral MSH2 P43246 G587T 587 G T 0.618 Pathogenic MSH2 P43246 G587V 587 G V 0.99 Pathogenic MSH2 P43246 G587W 587 G W 0.984 Pathogenic MSH2 P43246 G587Y 587 G Y 0.984 Pathogenic MSH2 P43246 Y588A 588 Y A 0.114 Neutral MSH2 P43246 Y588C 588 Y C 0.18 Neutral MSH2 P43246 Y588D 588 Y D 0.272 Neutral MSH2 P43246 Y588E 588 Y E 0.268 Neutral MSH2 P43246 Y588F 588 Y F 0.066 Neutral MSH2 P43246 Y588G 588 Y G 0.156 Neutral MSH2 P43246 Y588H 588 Y H 0.088 Neutral MSH2 P43246 Y588I 588 Y I 0.154 Neutral MSH2 P43246 Y588K 588 Y K 0.25 Neutral MSH2 P43246 Y588L 588 Y L 0.082 Neutral MSH2 P43246 Y588M 588 Y M 0.132 Neutral MSH2 P43246 Y588N 588 Y N 0.18 Neutral MSH2 P43246 Y588P 588 Y P 0.124 Neutral MSH2 P43246 Y588Q 588 Y Q 0.17 Neutral MSH2 P43246 Y588R 588 Y R 0.254 Neutral MSH2 P43246 Y588S 588 Y S 0.158 Neutral MSH2 P43246 Y588T 588 Y T 0.162 Neutral MSH2 P43246 Y588V 588 Y V 0.212 Neutral MSH2 P43246 Y588W 588 Y W 0.112 Neutral MSH2 P43246 V589A 589 V A 0.004 Neutral MSH2 P43246 V589C 589 V C 0.096 Neutral MSH2 P43246 V589D 589 V D 0.208 Neutral MSH2 P43246 V589E 589 V E 0.338 Neutral MSH2 P43246 V589F 589 V F 0.378 Neutral MSH2 P43246 V589G 589 V G 0.29 Neutral MSH2 P43246 V589H 589 V H 0.234 Neutral MSH2 P43246 V589I 589 V I 0.152 Neutral MSH2 P43246 V589K 589 V K 0.164 Neutral MSH2 P43246 V589L 589 V L 0.132 Neutral MSH2 P43246 V589M 589 V M 0.176 Neutral MSH2 P43246 V589N 589 V N 0.226 Neutral MSH2 P43246 V589P 589 V P 0.354 Neutral MSH2 P43246 V589Q 589 V Q 0.362 Neutral MSH2 P43246 V589R 589 V R 0.434 Neutral MSH2 P43246 V589S 589 V S 0.038 Neutral MSH2 P43246 V589T 589 V T 0.078 Neutral MSH2 P43246 V589W 589 V W 0.556 Pathogenic MSH2 P43246 V589Y 589 V Y 0.376 Neutral MSH2 P43246 K59A 59 K A 0.54 Pathogenic MSH2 P43246 K59C 59 K C 0.438 Neutral MSH2 P43246 K59D 59 K D 0.606 Pathogenic MSH2 P43246 K59E 59 K E 0.264 Neutral MSH2 P43246 K59F 59 K F 0.956 Pathogenic MSH2 P43246 K59G 59 K G 0.206 Neutral MSH2 P43246 K59H 59 K H 0.064 Neutral MSH2 P43246 K59I 59 K I 0.984 Pathogenic MSH2 P43246 K59L 59 K L 0.974 Pathogenic MSH2 P43246 K59M 59 K M 0.914 Pathogenic MSH2 P43246 K59N 59 K N 0.256 Neutral MSH2 P43246 K59P 59 K P 0.918 Pathogenic MSH2 P43246 K59Q 59 K Q 0.724 Pathogenic MSH2 P43246 K59R 59 K R 0.126 Neutral MSH2 P43246 K59S 59 K S 0.362 Neutral MSH2 P43246 K59T 59 K T 0.61 Pathogenic MSH2 P43246 K59V 59 K V 0.872 Pathogenic MSH2 P43246 K59W 59 K W 0.992 Pathogenic MSH2 P43246 K59Y 59 K Y 0.982 Pathogenic MSH2 P43246 E590A 590 E A 0.182 Neutral MSH2 P43246 E590C 590 E C 0.126 Neutral MSH2 P43246 E590D 590 E D 0.002 Neutral MSH2 P43246 E590F 590 E F 0.436 Neutral MSH2 P43246 E590G 590 E G 0.114 Neutral MSH2 P43246 E590H 590 E H 0.176 Neutral MSH2 P43246 E590I 590 E I 0.46 Neutral MSH2 P43246 E590K 590 E K 0.29 Neutral MSH2 P43246 E590L 590 E L 0.458 Neutral MSH2 P43246 E590M 590 E M 0.298 Neutral MSH2 P43246 E590N 590 E N 0.092 Neutral MSH2 P43246 E590P 590 E P 0.47 Neutral MSH2 P43246 E590Q 590 E Q 0.09 Neutral MSH2 P43246 E590R 590 E R 0.098 Neutral MSH2 P43246 E590S 590 E S 0.23 Neutral MSH2 P43246 E590T 590 E T 0.256 Neutral MSH2 P43246 E590V 590 E V 0.408 Neutral MSH2 P43246 E590W 590 E W 0.708 Pathogenic MSH2 P43246 E590Y 590 E Y 0.594 Pathogenic MSH2 P43246 P591A 591 P A 0.154 Neutral MSH2 P43246 P591C 591 P C 0.252 Neutral MSH2 P43246 P591D 591 P D 0.794 Pathogenic MSH2 P43246 P591E 591 P E 0.978 Pathogenic MSH2 P43246 P591F 591 P F 0.996 Pathogenic MSH2 P43246 P591G 591 P G 0.526 Pathogenic MSH2 P43246 P591H 591 P H 0.99 Pathogenic MSH2 P43246 P591I 591 P I 0.302 Neutral MSH2 P43246 P591K 591 P K 0.966 Pathogenic MSH2 P43246 P591L 591 P L 0.286 Neutral MSH2 P43246 P591M 591 P M 0.97 Pathogenic MSH2 P43246 P591N 591 P N 0.644 Pathogenic MSH2 P43246 P591Q 591 P Q 0.868 Pathogenic MSH2 P43246 P591R 591 P R 0.994 Pathogenic MSH2 P43246 P591S 591 P S 0.162 Neutral MSH2 P43246 P591T 591 P T 0.12 Neutral MSH2 P43246 P591V 591 P V 0.206 Neutral MSH2 P43246 P591W 591 P W 0.938 Pathogenic MSH2 P43246 P591Y 591 P Y 0.934 Pathogenic MSH2 P43246 M592A 592 M A 0.536 Pathogenic MSH2 P43246 M592C 592 M C 0.454 Neutral MSH2 P43246 M592D 592 M D 0.872 Pathogenic MSH2 P43246 M592E 592 M E 0.7 Pathogenic MSH2 P43246 M592F 592 M F 0.32 Neutral MSH2 P43246 M592G 592 M G 0.53 Pathogenic MSH2 P43246 M592H 592 M H 0.762 Pathogenic MSH2 P43246 M592I 592 M I 0.206 Neutral MSH2 P43246 M592K 592 M K 0.852 Pathogenic MSH2 P43246 M592L 592 M L 0.186 Neutral MSH2 P43246 M592N 592 M N 0.93 Pathogenic MSH2 P43246 M592P 592 M P 0.914 Pathogenic MSH2 P43246 M592Q 592 M Q 0.276 Neutral MSH2 P43246 M592R 592 M R 0.55 Pathogenic MSH2 P43246 M592S 592 M S 0.776 Pathogenic MSH2 P43246 M592T 592 M T 0.652 Pathogenic MSH2 P43246 M592V 592 M V 0.176 Neutral MSH2 P43246 M592W 592 M W 0.662 Pathogenic MSH2 P43246 M592Y 592 M Y 0.916 Pathogenic MSH2 P43246 Q593A 593 Q A 0.534 Pathogenic MSH2 P43246 Q593C 593 Q C 0.114 Neutral MSH2 P43246 Q593D 593 Q D 0.104 Neutral MSH2 P43246 Q593E 593 Q E 0.212 Neutral MSH2 P43246 Q593F 593 Q F 0.808 Pathogenic MSH2 P43246 Q593G 593 Q G 0.264 Neutral MSH2 P43246 Q593H 593 Q H 0.13 Neutral MSH2 P43246 Q593I 593 Q I 0.844 Pathogenic MSH2 P43246 Q593K 593 Q K 0.096 Neutral MSH2 P43246 Q593L 593 Q L 0.236 Neutral MSH2 P43246 Q593M 593 Q M 0.656 Pathogenic MSH2 P43246 Q593N 593 Q N 0.152 Neutral MSH2 P43246 Q593P 593 Q P 0.752 Pathogenic MSH2 P43246 Q593R 593 Q R 0.11 Neutral MSH2 P43246 Q593S 593 Q S 0.108 Neutral MSH2 P43246 Q593T 593 Q T 0.042 Neutral MSH2 P43246 Q593V 593 Q V 0.348 Neutral MSH2 P43246 Q593W 593 Q W 0.896 Pathogenic MSH2 P43246 Q593Y 593 Q Y 0.856 Pathogenic MSH2 P43246 T594A 594 T A 0.002 Neutral MSH2 P43246 T594C 594 T C 0.126 Neutral MSH2 P43246 T594D 594 T D 0.034 Neutral MSH2 P43246 T594E 594 T E 0.046 Neutral MSH2 P43246 T594F 594 T F 0.476 Neutral MSH2 P43246 T594G 594 T G 0.006 Neutral MSH2 P43246 T594H 594 T H 0.24 Neutral MSH2 P43246 T594I 594 T I 0.058 Neutral MSH2 P43246 T594K 594 T K 0.016 Neutral MSH2 P43246 T594L 594 T L 0.022 Neutral MSH2 P43246 T594M 594 T M 0.062 Neutral MSH2 P43246 T594N 594 T N 0.002 Neutral MSH2 P43246 T594P 594 T P 0.158 Neutral MSH2 P43246 T594Q 594 T Q 0.006 Neutral MSH2 P43246 T594R 594 T R 0.316 Neutral MSH2 P43246 T594S 594 T S 0.002 Neutral MSH2 P43246 T594V 594 T V 0.19 Neutral MSH2 P43246 T594W 594 T W 0.792 Pathogenic MSH2 P43246 T594Y 594 T Y 0.764 Pathogenic MSH2 P43246 L595A 595 L A 0.234 Neutral MSH2 P43246 L595C 595 L C 0.816 Pathogenic MSH2 P43246 L595D 595 L D 0.892 Pathogenic MSH2 P43246 L595E 595 L E 0.872 Pathogenic MSH2 P43246 L595F 595 L F 0.476 Neutral MSH2 P43246 L595G 595 L G 0.814 Pathogenic MSH2 P43246 L595H 595 L H 0.904 Pathogenic MSH2 P43246 L595I 595 L I 0.24 Neutral MSH2 P43246 L595K 595 L K 0.738 Pathogenic MSH2 P43246 L595M 595 L M 0.156 Neutral MSH2 P43246 L595N 595 L N 0.762 Pathogenic MSH2 P43246 L595P 595 L P 0.99 Pathogenic MSH2 P43246 L595Q 595 L Q 0.732 Pathogenic MSH2 P43246 L595R 595 L R 0.98 Pathogenic MSH2 P43246 L595S 595 L S 0.638 Pathogenic MSH2 P43246 L595T 595 L T 0.6 Pathogenic MSH2 P43246 L595V 595 L V 0.052 Neutral MSH2 P43246 L595W 595 L W 0.608 Pathogenic MSH2 P43246 L595Y 595 L Y 0.882 Pathogenic MSH2 P43246 N596A 596 N A 0.236 Neutral MSH2 P43246 N596C 596 N C 0.514 Pathogenic MSH2 P43246 N596D 596 N D 0.178 Neutral MSH2 P43246 N596E 596 N E 0.556 Pathogenic MSH2 P43246 N596F 596 N F 0.94 Pathogenic MSH2 P43246 N596G 596 N G 0.18 Neutral MSH2 P43246 N596H 596 N H 0.808 Pathogenic MSH2 P43246 N596I 596 N I 0.816 Pathogenic MSH2 P43246 N596K 596 N K 0.86 Pathogenic MSH2 P43246 N596L 596 N L 0.912 Pathogenic MSH2 P43246 N596M 596 N M 0.902 Pathogenic MSH2 P43246 N596P 596 N P 0.776 Pathogenic MSH2 P43246 N596Q 596 N Q 0.776 Pathogenic MSH2 P43246 N596R 596 N R 0.654 Pathogenic MSH2 P43246 N596S 596 N S 0.19 Neutral MSH2 P43246 N596T 596 N T 0.55 Pathogenic MSH2 P43246 N596V 596 N V 0.944 Pathogenic MSH2 P43246 N596W 596 N W 0.948 Pathogenic MSH2 P43246 N596Y 596 N Y 0.942 Pathogenic MSH2 P43246 D597A 597 D A 0.156 Neutral MSH2 P43246 D597C 597 D C 0.5 Pathogenic MSH2 P43246 D597E 597 D E 0.046 Neutral MSH2 P43246 D597F 597 D F 0.894 Pathogenic MSH2 P43246 D597G 597 D G 0.08 Neutral MSH2 P43246 D597H 597 D H 0.134 Neutral MSH2 P43246 D597I 597 D I 0.384 Neutral MSH2 P43246 D597K 597 D K 0.696 Pathogenic MSH2 P43246 D597L 597 D L 0.164 Neutral MSH2 P43246 D597M 597 D M 0.28 Neutral MSH2 P43246 D597N 597 D N 0.034 Neutral MSH2 P43246 D597P 597 D P 0.788 Pathogenic MSH2 P43246 D597Q 597 D Q 0.096 Neutral MSH2 P43246 D597R 597 D R 0.514 Pathogenic MSH2 P43246 D597S 597 D S 0.038 Neutral MSH2 P43246 D597T 597 D T 0.1 Neutral MSH2 P43246 D597V 597 D V 0.178 Neutral MSH2 P43246 D597W 597 D W 0.94 Pathogenic MSH2 P43246 D597Y 597 D Y 0.946 Pathogenic MSH2 P43246 V598A 598 V A 0.134 Neutral MSH2 P43246 V598C 598 V C 0.714 Pathogenic MSH2 P43246 V598D 598 V D 0.862 Pathogenic MSH2 P43246 V598E 598 V E 0.24 Neutral MSH2 P43246 V598F 598 V F 0.65 Pathogenic MSH2 P43246 V598G 598 V G 0.898 Pathogenic MSH2 P43246 V598H 598 V H 0.44 Neutral MSH2 P43246 V598I 598 V I 0.158 Neutral MSH2 P43246 V598K 598 V K 0.984 Pathogenic MSH2 P43246 V598L 598 V L 0.202 Neutral MSH2 P43246 V598M 598 V M 0.234 Neutral MSH2 P43246 V598N 598 V N 0.546 Pathogenic MSH2 P43246 V598P 598 V P 0.978 Pathogenic MSH2 P43246 V598Q 598 V Q 0.264 Neutral MSH2 P43246 V598R 598 V R 0.96 Pathogenic MSH2 P43246 V598S 598 V S 0.2 Neutral MSH2 P43246 V598T 598 V T 0.306 Neutral MSH2 P43246 V598W 598 V W 0.904 Pathogenic MSH2 P43246 V598Y 598 V Y 0.93 Pathogenic MSH2 P43246 L599A 599 L A 0.212 Neutral MSH2 P43246 L599C 599 L C 0.686 Pathogenic MSH2 P43246 L599D 599 L D 0.872 Pathogenic MSH2 P43246 L599E 599 L E 0.858 Pathogenic MSH2 P43246 L599F 599 L F 0.792 Pathogenic MSH2 P43246 L599G 599 L G 0.466 Neutral MSH2 P43246 L599H 599 L H 0.816 Pathogenic MSH2 P43246 L599I 599 L I 0.158 Neutral MSH2 P43246 L599K 599 L K 0.436 Neutral MSH2 P43246 L599M 599 L M 0.462 Neutral MSH2 P43246 L599N 599 L N 0.738 Pathogenic MSH2 P43246 L599P 599 L P 0.976 Pathogenic MSH2 P43246 L599Q 599 L Q 0.616 Pathogenic MSH2 P43246 L599R 599 L R 0.98 Pathogenic MSH2 P43246 L599S 599 L S 0.334 Neutral MSH2 P43246 L599T 599 L T 0.13 Neutral MSH2 P43246 L599V 599 L V 0.086 Neutral MSH2 P43246 L599W 599 L W 0.938 Pathogenic MSH2 P43246 L599Y 599 L Y 0.902 Pathogenic MSH2 P43246 K6A 6 K A 0.068 Neutral MSH2 P43246 K6C 6 K C 0.06 Neutral MSH2 P43246 K6D 6 K D 0.056 Neutral MSH2 P43246 K6E 6 K E 0.006 Neutral MSH2 P43246 K6F 6 K F 0.368 Neutral MSH2 P43246 K6G 6 K G 0.182 Neutral MSH2 P43246 K6H 6 K H 0.086 Neutral MSH2 P43246 K6I 6 K I 0.4 Neutral MSH2 P43246 K6L 6 K L 0.164 Neutral MSH2 P43246 K6M 6 K M 0.194 Neutral MSH2 P43246 K6N 6 K N 0.01 Neutral MSH2 P43246 K6P 6 K P 0.368 Neutral MSH2 P43246 K6Q 6 K Q 0.07 Neutral MSH2 P43246 K6R 6 K R 0.014 Neutral MSH2 P43246 K6S 6 K S 0.244 Neutral MSH2 P43246 K6T 6 K T 0.112 Neutral MSH2 P43246 K6V 6 K V 0.306 Neutral MSH2 P43246 K6W 6 K W 0.682 Pathogenic MSH2 P43246 K6Y 6 K Y 0.586 Pathogenic MSH2 P43246 T60A 60 T A 0.7 Pathogenic MSH2 P43246 T60C 60 T C 0.928 Pathogenic MSH2 P43246 T60D 60 T D 0.936 Pathogenic MSH2 P43246 T60E 60 T E 0.936 Pathogenic MSH2 P43246 T60F 60 T F 0.95 Pathogenic MSH2 P43246 T60G 60 T G 0.738 Pathogenic MSH2 P43246 T60H 60 T H 0.918 Pathogenic MSH2 P43246 T60I 60 T I 0.948 Pathogenic MSH2 P43246 T60K 60 T K 0.934 Pathogenic MSH2 P43246 T60L 60 T L 0.942 Pathogenic MSH2 P43246 T60M 60 T M 0.974 Pathogenic MSH2 P43246 T60N 60 T N 0.88 Pathogenic MSH2 P43246 T60P 60 T P 0.952 Pathogenic MSH2 P43246 T60Q 60 T Q 0.88 Pathogenic MSH2 P43246 T60R 60 T R 0.992 Pathogenic MSH2 P43246 T60S 60 T S 0.17 Neutral MSH2 P43246 T60V 60 T V 0.798 Pathogenic MSH2 P43246 T60W 60 T W 0.954 Pathogenic MSH2 P43246 T60Y 60 T Y 0.954 Pathogenic MSH2 P43246 A600C 600 A C 0.854 Pathogenic MSH2 P43246 A600D 600 A D 0.924 Pathogenic MSH2 P43246 A600E 600 A E 0.874 Pathogenic MSH2 P43246 A600F 600 A F 0.964 Pathogenic MSH2 P43246 A600G 600 A G 0.32 Neutral MSH2 P43246 A600H 600 A H 0.862 Pathogenic MSH2 P43246 A600I 600 A I 0.958 Pathogenic MSH2 P43246 A600K 600 A K 0.934 Pathogenic MSH2 P43246 A600L 600 A L 0.924 Pathogenic MSH2 P43246 A600M 600 A M 0.848 Pathogenic MSH2 P43246 A600N 600 A N 0.858 Pathogenic MSH2 P43246 A600P 600 A P 0.968 Pathogenic MSH2 P43246 A600Q 600 A Q 0.812 Pathogenic MSH2 P43246 A600R 600 A R 0.958 Pathogenic MSH2 P43246 A600S 600 A S 0.284 Neutral MSH2 P43246 A600T 600 A T 0.724 Pathogenic MSH2 P43246 A600V 600 A V 0.908 Pathogenic MSH2 P43246 A600W 600 A W 0.974 Pathogenic MSH2 P43246 A600Y 600 A Y 0.962 Pathogenic MSH2 P43246 Q601A 601 Q A 0.374 Neutral MSH2 P43246 Q601C 601 Q C 0.054 Neutral MSH2 P43246 Q601D 601 Q D 0.056 Neutral MSH2 P43246 Q601E 601 Q E 0.022 Neutral MSH2 P43246 Q601F 601 Q F 0.824 Pathogenic MSH2 P43246 Q601G 601 Q G 0.444 Neutral MSH2 P43246 Q601H 601 Q H 0.238 Neutral MSH2 P43246 Q601I 601 Q I 0.828 Pathogenic MSH2 P43246 Q601K 601 Q K 0.084 Neutral MSH2 P43246 Q601L 601 Q L 0.73 Pathogenic MSH2 P43246 Q601M 601 Q M 0.716 Pathogenic MSH2 P43246 Q601N 601 Q N 0.096 Neutral MSH2 P43246 Q601P 601 Q P 0.826 Pathogenic MSH2 P43246 Q601R 601 Q R 0.27 Neutral MSH2 P43246 Q601S 601 Q S 0.28 Neutral MSH2 P43246 Q601T 601 Q T 0.028 Neutral MSH2 P43246 Q601V 601 Q V 0.688 Pathogenic MSH2 P43246 Q601W 601 Q W 0.78 Pathogenic MSH2 P43246 Q601Y 601 Q Y 0.892 Pathogenic MSH2 P43246 L602A 602 L A 0.714 Pathogenic MSH2 P43246 L602C 602 L C 0.406 Neutral MSH2 P43246 L602D 602 L D 0.9 Pathogenic MSH2 P43246 L602E 602 L E 0.882 Pathogenic MSH2 P43246 L602F 602 L F 0.676 Pathogenic MSH2 P43246 L602G 602 L G 0.87 Pathogenic MSH2 P43246 L602H 602 L H 0.906 Pathogenic MSH2 P43246 L602I 602 L I 0.286 Neutral MSH2 P43246 L602K 602 L K 0.71 Pathogenic MSH2 P43246 L602M 602 L M 0.19 Neutral MSH2 P43246 L602N 602 L N 0.81 Pathogenic MSH2 P43246 L602P 602 L P 0.978 Pathogenic MSH2 P43246 L602Q 602 L Q 0.764 Pathogenic MSH2 P43246 L602R 602 L R 0.982 Pathogenic MSH2 P43246 L602S 602 L S 0.698 Pathogenic MSH2 P43246 L602T 602 L T 0.614 Pathogenic MSH2 P43246 L602V 602 L V 0.122 Neutral MSH2 P43246 L602W 602 L W 0.862 Pathogenic MSH2 P43246 L602Y 602 L Y 0.744 Pathogenic MSH2 P43246 D603A 603 D A 0.794 Pathogenic MSH2 P43246 D603C 603 D C 0.89 Pathogenic MSH2 P43246 D603E 603 D E 0.82 Pathogenic MSH2 P43246 D603F 603 D F 0.978 Pathogenic MSH2 P43246 D603G 603 D G 0.956 Pathogenic 4 MSH2 P43246 D603H 603 D H 0.638 Pathogenic MSH2 P43246 D603I 603 D I 0.972 Pathogenic MSH2 P43246 D603K 603 D K 0.928 Pathogenic MSH2 P43246 D603L 603 D L 0.978 Pathogenic MSH2 P43246 D603M 603 D M 0.956 Pathogenic MSH2 P43246 D603N 603 D N 0.868 Pathogenic MSH2 P43246 D603P 603 D P 0.91 Pathogenic MSH2 P43246 D603Q 603 D Q 0.64 Pathogenic MSH2 P43246 D603R 603 D R 0.958 Pathogenic MSH2 P43246 D603S 603 D S 0.392 Neutral MSH2 P43246 D603T 603 D T 0.808 Pathogenic MSH2 P43246 D603V 603 D V 0.992 Pathogenic MSH2 P43246 D603W 603 D W 0.982 Pathogenic MSH2 P43246 D603Y 603 D Y 0.976 Pathogenic MSH2 P43246 A604C 604 A C 0.38 Neutral MSH2 P43246 A604D 604 A D 0.954 Pathogenic MSH2 P43246 A604E 604 A E 0.972 Pathogenic MSH2 P43246 A604F 604 A F 0.996 Pathogenic MSH2 P43246 A604G 604 A G 0.78 Pathogenic MSH2 P43246 A604H 604 A H 0.936 Pathogenic MSH2 P43246 A604I 604 A I 0.816 Pathogenic MSH2 P43246 A604K 604 A K 0.974 Pathogenic MSH2 P43246 A604L 604 A L 0.704 Pathogenic MSH2 P43246 A604M 604 A M 0.908 Pathogenic MSH2 P43246 A604N 604 A N 0.87 Pathogenic MSH2 P43246 A604P 604 A P 0.978 Pathogenic MSH2 P43246 A604Q 604 A Q 0.886 Pathogenic MSH2 P43246 A604R 604 A R 0.976 Pathogenic MSH2 P43246 A604S 604 A S 0.57 Pathogenic MSH2 P43246 A604T 604 A T 0.368 Neutral MSH2 P43246 A604V 604 A V 0.504 Pathogenic MSH2 P43246 A604W 604 A W 0.996 Pathogenic MSH2 P43246 A604Y 604 A Y 0.972 Pathogenic MSH2 P43246 V605A 605 V A 0.102 Neutral MSH2 P43246 V605C 605 V C 0.338 Neutral MSH2 P43246 V605D 605 V D 0.862 Pathogenic MSH2 P43246 V605E 605 V E 0.976 Pathogenic MSH2 P43246 V605F 605 V F 0.526 Pathogenic MSH2 P43246 V605G 605 V G 0.906 Pathogenic MSH2 P43246 V605H 605 V H 0.806 Pathogenic MSH2 P43246 V605I 605 V I 0.206 Neutral MSH2 P43246 V605K 605 V K 0.968 Pathogenic MSH2 P43246 V605L 605 V L 0.178 Neutral MSH2 P43246 V605M 605 V M 0.256 Neutral MSH2 P43246 V605N 605 V N 0.93 Pathogenic MSH2 P43246 V605P 605 V P 0.966 Pathogenic MSH2 P43246 V605Q 605 V Q 0.988 Pathogenic MSH2 P43246 V605R 605 V R 0.956 Pathogenic MSH2 P43246 V605S 605 V S 0.738 Pathogenic MSH2 P43246 V605T 605 V T 0.162 Neutral MSH2 P43246 V605W 605 V W 0.898 Pathogenic MSH2 P43246 V605Y 605 V Y 0.6 Pathogenic MSH2 P43246 V606A 606 V A 0.07 Neutral MSH2 P43246 V606C 606 V C 0.13 Neutral MSH2 P43246 V606D 606 V D 0.872 Pathogenic MSH2 P43246 V606E 606 V E 0.982 Pathogenic MSH2 P43246 V606F 606 V F 0.876 Pathogenic MSH2 P43246 V606G 606 V G 0.904 Pathogenic MSH2 P43246 V606H 606 V H 0.82 Pathogenic MSH2 P43246 V606I 606 V I 0.198 Neutral MSH2 P43246 V606K 606 V K 0.984 Pathogenic MSH2 P43246 V606L 606 V L 0.206 Neutral MSH2 P43246 V606M 606 V M 0.292 Neutral MSH2 P43246 V606N 606 V N 0.548 Pathogenic MSH2 P43246 V606P 606 V P 0.978 Pathogenic MSH2 P43246 V606Q 606 V Q 0.278 Neutral MSH2 P43246 V606R 606 V R 0.96 Pathogenic MSH2 P43246 V606S 606 V S 0.366 Neutral MSH2 P43246 V606T 606 V T 0.11 Neutral MSH2 P43246 V606W 606 V W 0.904 Pathogenic MSH2 P43246 V606Y 606 V Y 0.93 Pathogenic MSH2 P43246 S607A 607 S A 0.27 Neutral MSH2 P43246 S607C 607 S C 0.884 Pathogenic MSH2 P43246 S607D 607 S D 0.602 Pathogenic MSH2 P43246 S607E 607 S E 0.95 Pathogenic MSH2 P43246 S607F 607 S F 0.976 Pathogenic MSH2 P43246 S607G 607 S G 0.206 Neutral MSH2 P43246 S607H 607 S H 0.968 Pathogenic MSH2 P43246 S607I 607 S I 0.872 Pathogenic MSH2 P43246 S607K 607 S K 0.946 Pathogenic MSH2 P43246 S607L 607 S L 0.912 Pathogenic MSH2 P43246 S607M 607 S M 0.99 Pathogenic MSH2 P43246 S607N 607 S N 0.504 Pathogenic MSH2 P43246 S607P 607 S P 0.956 Pathogenic MSH2 P43246 S607Q 607 S Q 0.938 Pathogenic MSH2 P43246 S607R 607 S R 0.61 Pathogenic MSH2 P43246 S607T 607 S T 0.47 Neutral MSH2 P43246 S607V 607 S V 0.93 Pathogenic MSH2 P43246 S607W 607 S W 0.926 Pathogenic MSH2 P43246 S607Y 607 S Y 0.934 Pathogenic MSH2 P43246 F608A 608 F A 0.496 Neutral MSH2 P43246 F608C 608 F C 0.714 Pathogenic MSH2 P43246 F608D 608 F D 0.79 Pathogenic MSH2 P43246 F608E 608 F E 0.836 Pathogenic MSH2 P43246 F608G 608 F G 0.5 Pathogenic MSH2 P43246 F608H 608 F H 0.748 Pathogenic MSH2 P43246 F608I 608 F I 0.312 Neutral MSH2 P43246 F608K 608 F K 0.816 Pathogenic MSH2 P43246 F608L 608 F L 0.17 Neutral MSH2 P43246 F608M 608 F M 0.2 Neutral MSH2 P43246 F608N 608 F N 0.736 Pathogenic MSH2 P43246 F608P 608 F P 0.944 Pathogenic MSH2 P43246 F608Q 608 F Q 0.468 Neutral MSH2 P43246 F608R 608 F R 0.884 Pathogenic MSH2 P43246 F608S 608 F S 0.848 Pathogenic MSH2 P43246 F608T 608 F T 0.544 Pathogenic MSH2 P43246 F608V 608 F V 0.694 Pathogenic MSH2 P43246 F608W 608 F W 0.832 Pathogenic MSH2 P43246 F608Y 608 F Y 0.422 Neutral MSH2 P43246 A609C 609 A C 0.856 Pathogenic MSH2 P43246 A609D 609 A D 0.926 Pathogenic MSH2 P43246 A609E 609 A E 0.876 Pathogenic MSH2 P43246 A609F 609 A F 0.966 Pathogenic MSH2 P43246 A609G 609 A G 0.488 Neutral MSH2 P43246 A609H 609 A H 0.866 Pathogenic MSH2 P43246 A609I 609 A I 0.928 Pathogenic MSH2 P43246 A609K 609 A K 0.936 Pathogenic MSH2 P43246 A609L 609 A L 0.98 Pathogenic MSH2 P43246 A609M 609 A M 0.852 Pathogenic MSH2 P43246 A609N 609 A N 0.678 Pathogenic MSH2 P43246 A609P 609 A P 0.968 Pathogenic MSH2 P43246 A609Q 609 A Q 0.816 Pathogenic MSH2 P43246 A609R 609 A R 0.958 Pathogenic MSH2 P43246 A609S 609 A S 0.298 Neutral MSH2 P43246 A609T 609 A T 0.728 Pathogenic MSH2 P43246 A609V 609 A V 0.87 Pathogenic MSH2 P43246 A609W 609 A W 0.976 Pathogenic MSH2 P43246 A609Y 609 A Y 0.964 Pathogenic MSH2 P43246 Q61A 61 Q A 0.408 Neutral MSH2 P43246 Q61C 61 Q C 0.454 Neutral MSH2 P43246 Q61D 61 Q D 0.49 Neutral MSH2 P43246 Q61E 61 Q E 0.56 Pathogenic MSH2 P43246 Q61F 61 Q F 0.81 Pathogenic MSH2 P43246 Q61G 61 Q G 0.458 Neutral MSH2 P43246 Q61H 61 Q H 0.106 Neutral MSH2 P43246 Q61I 61 Q I 0.454 Neutral MSH2 P43246 Q61K 61 Q K 0.086 Neutral MSH2 P43246 Q61L 61 Q L 0.216 Neutral MSH2 P43246 Q61M 61 Q M 0.1 Neutral MSH2 P43246 Q61N 61 Q N 0.104 Neutral MSH2 P43246 Q61P 61 Q P 0.84 Pathogenic MSH2 P43246 Q61R 61 Q R 0.112 Neutral MSH2 P43246 Q61S 61 Q S 0.108 Neutral MSH2 P43246 Q61T 61 Q T 0.248 Neutral MSH2 P43246 Q61V 61 Q V 0.114 Neutral MSH2 P43246 Q61W 61 Q W 0.93 Pathogenic MSH2 P43246 Q61Y 61 Q Y 0.89 Pathogenic MSH2 P43246 H610A 610 H A 0.076 Neutral MSH2 P43246 H610C 610 H C 0.048 Neutral MSH2 P43246 H610D 610 H D 0.028 Neutral MSH2 P43246 H610E 610 H E 0.022 Neutral MSH2 P43246 H610F 610 H F 0.254 Neutral MSH2 P43246 H610G 610 H G 0.112 Neutral MSH2 P43246 H610I 610 H I 0.018 Neutral MSH2 P43246 H610K 610 H K 0.146 Neutral MSH2 P43246 H610L 610 H L 0.016 Neutral MSH2 P43246 H610M 610 H M 0.138 Neutral MSH2 P43246 H610N 610 H N 0.014 Neutral MSH2 P43246 H610P 610 H P 0.29 Neutral MSH2 P43246 H610Q 610 H Q 0.006 Neutral MSH2 P43246 H610R 610 H R 0.046 Neutral MSH2 P43246 H610S 610 H S 0.012 Neutral MSH2 P43246 H610T 610 H T 0.162 Neutral MSH2 P43246 H610V 610 H V 0.018 Neutral MSH2 P43246 H610W 610 H W 0.436 Neutral MSH2 P43246 H610Y 610 H Y 0.078 Neutral MSH2 P43246 V611A 611 V A 0.082 Neutral MSH2 P43246 V611C 611 V C 0.128 Neutral MSH2 P43246 V611D 611 V D 0.868 Pathogenic MSH2 P43246 V611E 611 V E 0.982 Pathogenic MSH2 P43246 V611F 611 V F 0.872 Pathogenic MSH2 P43246 V611G 611 V G 0.908 Pathogenic MSH2 P43246 V611H 611 V H 0.814 Pathogenic MSH2 P43246 V611I 611 V I 0.244 Neutral MSH2 P43246 V611K 611 V K 0.974 Pathogenic MSH2 P43246 V611L 611 V L 0.214 Neutral MSH2 P43246 V611M 611 V M 0.812 Pathogenic MSH2 P43246 V611N 611 V N 0.934 Pathogenic MSH2 P43246 V611P 611 V P 0.974 Pathogenic MSH2 P43246 V611Q 611 V Q 0.992 Pathogenic MSH2 P43246 V611R 611 V R 0.96 Pathogenic MSH2 P43246 V611S 611 V S 0.154 Neutral MSH2 P43246 V611T 611 V T 0.164 Neutral MSH2 P43246 V611W 611 V W 0.902 Pathogenic MSH2 P43246 V611Y 611 V Y 0.69 Pathogenic MSH2 P43246 S612A 612 S A 0.21 Neutral MSH2 P43246 S612C 612 S C 0.9 Pathogenic MSH2 P43246 S612D 612 S D 0.904 Pathogenic MSH2 P43246 S612E 612 S E 0.958 Pathogenic MSH2 P43246 S612F 612 S F 0.982 Pathogenic MSH2 P43246 S612G 612 S G 0.246 Neutral MSH2 P43246 S612H 612 S H 0.974 Pathogenic MSH2 P43246 S612I 612 S I 0.776 Pathogenic MSH2 P43246 S612K 612 S K 0.954 Pathogenic MSH2 P43246 S612L 612 S L 0.924 Pathogenic MSH2 P43246 S612M 612 S M 0.998 Pathogenic MSH2 P43246 S612N 612 S N 0.888 Pathogenic MSH2 P43246 S612P 612 S P 0.97 Pathogenic MSH2 P43246 S612Q 612 S Q 0.948 Pathogenic MSH2 P43246 S612R 612 S R 0.972 Pathogenic MSH2 P43246 S612T 612 S T 0.806 Pathogenic MSH2 P43246 S612V 612 S V 0.958 Pathogenic MSH2 P43246 S612W 612 S W 0.952 Pathogenic MSH2 P43246 S612Y 612 S Y 0.96 Pathogenic MSH2 P43246 N613A 613 N A 0.086 Neutral MSH2 P43246 N613C 613 N C 0.578 Pathogenic MSH2 P43246 N613D 613 N D 0.054 Neutral MSH2 P43246 N613E 613 N E 0.08 Neutral MSH2 P43246 N613F 613 N F 0.906 Pathogenic MSH2 P43246 N613G 613 N G 0.61 Pathogenic MSH2 P43246 N613H 613 N H 0.424 Neutral MSH2 P43246 N613I 613 N I 0.35 Neutral MSH2 P43246 N613K 613 N K 0.788 Pathogenic MSH2 P43246 N613L 613 N L 0.18 Neutral MSH2 P43246 N613M 613 N M 0.138 Neutral MSH2 P43246 N613P 613 N P 0.748 Pathogenic MSH2 P43246 N613Q 613 N Q 0.324 Neutral MSH2 P43246 N613R 613 N R 0.476 Neutral MSH2 P43246 N613S 613 N S 0.042 Neutral MSH2 P43246 N613T 613 N T 0.038 Neutral MSH2 P43246 N613V 613 N V 0.152 Neutral MSH2 P43246 N613W 613 N W 0.954 Pathogenic MSH2 P43246 N613Y 613 N Y 0.946 Pathogenic MSH2 P43246 G614A 614 G A 0.102 Neutral MSH2 P43246 G614C 614 G C 0.524 Pathogenic MSH2 P43246 G614D 614 G D 0.686 Pathogenic MSH2 P43246 G614E 614 G E 0.702 Pathogenic MSH2 P43246 G614F 614 G F 0.802 Pathogenic MSH2 P43246 G614H 614 G H 0.608 Pathogenic MSH2 P43246 G614I 614 G I 0.748 Pathogenic MSH2 P43246 G614K 614 G K 0.774 Pathogenic MSH2 P43246 G614L 614 G L 0.95 Pathogenic MSH2 P43246 G614M 614 G M 0.776 Pathogenic MSH2 P43246 G614N 614 G N 0.478 Neutral MSH2 P43246 G614P 614 G P 0.93 Pathogenic MSH2 P43246 G614Q 614 G Q 0.76 Pathogenic MSH2 P43246 G614R 614 G R 0.924 Pathogenic MSH2 P43246 G614S 614 G S 0.108 Neutral MSH2 P43246 G614T 614 G T 0.638 Pathogenic MSH2 P43246 G614V 614 G V 0.974 Pathogenic MSH2 P43246 G614W 614 G W 0.958 Pathogenic MSH2 P43246 G614Y 614 G Y 0.688 Pathogenic MSH2 P43246 A615C 615 A C 0.362 Neutral MSH2 P43246 A615D 615 A D 0.896 Pathogenic MSH2 P43246 A615E 615 A E 0.842 Pathogenic MSH2 P43246 A615F 615 A F 0.94 Pathogenic MSH2 P43246 A615G 615 A G 0.318 Neutral MSH2 P43246 A615H 615 A H 0.834 Pathogenic MSH2 P43246 A615I 615 A I 0.94 Pathogenic MSH2 P43246 A615K 615 A K 0.908 Pathogenic MSH2 P43246 A615L 615 A L 0.866 Pathogenic MSH2 P43246 A615M 615 A M 0.82 Pathogenic MSH2 P43246 A615N 615 A N 0.828 Pathogenic MSH2 P43246 A615P 615 A P 0.95 Pathogenic MSH2 P43246 A615Q 615 A Q 0.78 Pathogenic MSH2 P43246 A615R 615 A R 0.942 Pathogenic MSH2 P43246 A615S 615 A S 0.1 Neutral MSH2 P43246 A615T 615 A T 0.242 Neutral MSH2 P43246 A615V 615 A V 0.884 Pathogenic MSH2 P43246 A615W 615 A W 0.95 Pathogenic MSH2 P43246 A615Y 615 A Y 0.946 Pathogenic MSH2 P43246 P616A 616 P A 0.244 Neutral MSH2 P43246 P616C 616 P C 0.91 Pathogenic MSH2 P43246 P616D 616 P D 0.862 Pathogenic MSH2 P43246 P616E 616 P E 0.956 Pathogenic MSH2 P43246 P616F 616 P F 0.996 Pathogenic MSH2 P43246 P616G 616 P G 0.694 Pathogenic MSH2 P43246 P616H 616 P H 0.976 Pathogenic MSH2 P43246 P616I 616 P I 0.924 Pathogenic MSH2 P43246 P616K 616 P K 0.946 Pathogenic MSH2 P43246 P616L 616 P L 0.718 Pathogenic MSH2 P43246 P616M 616 P M 0.958 Pathogenic MSH2 P43246 P616N 616 P N 0.28 Neutral MSH2 P43246 P616Q 616 P Q 0.356 Neutral MSH2 P43246 P616R 616 P R 0.708 Pathogenic MSH2 P43246 P616S 616 P S 0.326 Neutral MSH2 P43246 P616T 616 P T 0.734 Pathogenic MSH2 P43246 P616V 616 P V 0.252 Neutral MSH2 P43246 P616W 616 P W 0.928 Pathogenic MSH2 P43246 P616Y 616 P Y 0.922 Pathogenic MSH2 P43246 V617A 617 V A 0.022 Neutral MSH2 P43246 V617C 617 V C 0.372 Neutral MSH2 P43246 V617D 617 V D 0.592 Pathogenic MSH2 P43246 V617E 617 V E 0.112 Neutral MSH2 P43246 V617F 617 V F 0.744 Pathogenic MSH2 P43246 V617G 617 V G 0.5 Pathogenic MSH2 P43246 V617H 617 V H 0.516 Pathogenic MSH2 P43246 V617I 617 V I 0.06 Neutral MSH2 P43246 V617K 617 V K 0.182 Neutral MSH2 P43246 V617L 617 V L 0.076 Neutral MSH2 P43246 V617M 617 V M 0.07 Neutral MSH2 P43246 V617N 617 V N 0.518 Pathogenic MSH2 P43246 V617P 617 V P 0.858 Pathogenic MSH2 P43246 V617Q 617 V Q 0.706 Pathogenic MSH2 P43246 V617R 617 V R 0.836 Pathogenic MSH2 P43246 V617S 617 V S 0.042 Neutral MSH2 P43246 V617T 617 V T 0.018 Neutral MSH2 P43246 V617W 617 V W 0.688 Pathogenic MSH2 P43246 V617Y 617 V Y 0.56 Pathogenic MSH2 P43246 P618A 618 P A 0.158 Neutral MSH2 P43246 P618C 618 P C 0.922 Pathogenic MSH2 P43246 P618D 618 P D 0.402 Neutral MSH2 P43246 P618E 618 P E 0.266 Neutral MSH2 P43246 P618F 618 P F 0.812 Pathogenic MSH2 P43246 P618G 618 P G 0.124 Neutral MSH2 P43246 P618H 618 P H 0.992 Pathogenic MSH2 P43246 P618I 618 P I 0.682 Pathogenic MSH2 P43246 P618K 618 P K 0.588 Pathogenic MSH2 P43246 P618L 618 P L 0.656 Pathogenic MSH2 P43246 P618M 618 P M 0.628 Pathogenic MSH2 P43246 P618N 618 P N 0.314 Neutral MSH2 P43246 P618Q 618 P Q 0.26 Neutral MSH2 P43246 P618R 618 P R 0.704 Pathogenic MSH2 P43246 P618S 618 P S 0.092 Neutral MSH2 P43246 P618T 618 P T 0.12 Neutral MSH2 P43246 P618V 618 P V 0.146 Neutral MSH2 P43246 P618W 618 P W 0.912 Pathogenic MSH2 P43246 P618Y 618 P Y 0.896 Pathogenic MSH2 P43246 Y619A 619 Y A 0.438 Neutral MSH2 P43246 Y619C 619 Y C 0.694 Pathogenic MSH2 P43246 Y619D 619 Y D 0.852 Pathogenic MSH2 P43246 Y619E 619 Y E 0.762 Pathogenic MSH2 P43246 Y619F 619 Y F 0.364 Neutral MSH2 P43246 Y619G 619 Y G 0.486 Neutral MSH2 P43246 Y619H 619 Y H 0.614 Pathogenic MSH2 P43246 Y619I 619 Y I 0.512 Pathogenic MSH2 P43246 Y619K 619 Y K 0.828 Pathogenic MSH2 P43246 Y619L 619 Y L 0.432 Neutral MSH2 P43246 Y619M 619 Y M 0.694 Pathogenic MSH2 P43246 Y619N 619 Y N 0.75 Pathogenic MSH2 P43246 Y619P 619 Y P 0.788 Pathogenic MSH2 P43246 Y619Q 619 Y Q 0.67 Pathogenic MSH2 P43246 Y619R 619 Y R 0.62 Pathogenic MSH2 P43246 Y619S 619 Y S 0.486 Neutral MSH2 P43246 Y619T 619 Y T 0.69 Pathogenic MSH2 P43246 Y619V 619 Y V 0.664 Pathogenic MSH2 P43246 Y619W 619 Y W 0.914 Pathogenic MSH2 P43246 G62A 62 G A 0.056 Neutral MSH2 P43246 G62C 62 G C 0.808 Pathogenic MSH2 P43246 G62D 62 G D 0.672 Pathogenic MSH2 P43246 G62E 62 G E 0.956 Pathogenic MSH2 P43246 G62F 62 G F 0.972 Pathogenic MSH2 P43246 G62H 62 G H 0.966 Pathogenic MSH2 P43246 G62I 62 G I 0.958 Pathogenic MSH2 P43246 G62K 62 G K 0.602 Pathogenic MSH2 P43246 G62L 62 G L 0.968 Pathogenic MSH2 P43246 G62M 62 G M 0.984 Pathogenic MSH2 P43246 G62N 62 G N 0.51 Pathogenic MSH2 P43246 G62P 62 G P 0.932 Pathogenic MSH2 P43246 G62Q 62 G Q 0.634 Pathogenic MSH2 P43246 G62R 62 G R 0.986 Pathogenic MSH2 P43246 G62S 62 G S 0.234 Neutral MSH2 P43246 G62T 62 G T 0.564 Pathogenic MSH2 P43246 G62V 62 G V 0.974 Pathogenic MSH2 P43246 G62W 62 G W 0.958 Pathogenic MSH2 P43246 G62Y 62 G Y 0.95 Pathogenic MSH2 P43246 V620A 620 V A 0.184 Neutral MSH2 P43246 V620C 620 V C 0.222 Neutral MSH2 P43246 V620D 620 V D 0.86 Pathogenic MSH2 P43246 V620E 620 V E 0.964 Pathogenic MSH2 P43246 V620F 620 V F 0.93 Pathogenic MSH2 P43246 V620G 620 V G 0.912 Pathogenic MSH2 P43246 V620H 620 V H 0.898 Pathogenic MSH2 P43246 V620I 620 V I 0.24 Neutral MSH2 P43246 V620K 620 V K 0.986 Pathogenic MSH2 P43246 V620L 620 V L 0.944 Pathogenic MSH2 P43246 V620M 620 V M 0.908 Pathogenic MSH2 P43246 V620N 620 V N 0.556 Pathogenic MSH2 P43246 V620P 620 V P 0.708 Pathogenic MSH2 P43246 V620Q 620 V Q 0.592 Pathogenic MSH2 P43246 V620R 620 V R 0.948 Pathogenic MSH2 P43246 V620S 620 V S 0.42 Neutral MSH2 P43246 V620T 620 V T 0.182 Neutral MSH2 P43246 V620W 620 V W 0.954 Pathogenic MSH2 P43246 V620Y 620 V Y 0.974 Pathogenic MSH2 P43246 R621A 621 R A 0.562 Pathogenic MSH2 P43246 R621C 621 R C 0.294 Neutral MSH2 P43246 R621D 621 R D 0.644 Pathogenic MSH2 P43246 R621E 621 R E 0.75 Pathogenic MSH2 P43246 R621F 621 R F 0.96 Pathogenic MSH2 P43246 R621G 621 R G 0.396 Neutral MSH2 P43246 R621H 621 R H 0.326 Neutral MSH2 P43246 R621I 621 R I 0.966 Pathogenic MSH2 P43246 R621K 621 R K 0.29 Neutral MSH2 P43246 R621L 621 R L 0.978 Pathogenic MSH2 P43246 R621M 621 R M 0.754 Pathogenic MSH2 P43246 R621N 621 R N 0.596 Pathogenic MSH2 P43246 R621P 621 R P 0.978 Pathogenic MSH2 P43246 R621Q 621 R Q 0.236 Neutral MSH2 P43246 R621S 621 R S 0.892 Pathogenic MSH2 P43246 R621T 621 R T 0.914 Pathogenic MSH2 P43246 R621V 621 R V 0.452 Neutral MSH2 P43246 R621W 621 R W 0.94 Pathogenic MSH2 P43246 R621Y 621 R Y 0.944 Pathogenic MSH2 P43246 P622A 622 P A 0.844 Pathogenic MSH2 P43246 P622C 622 P C 0.922 Pathogenic MSH2 P43246 P622D 622 P D 0.874 Pathogenic MSH2 P43246 P622E 622 P E 0.956 Pathogenic MSH2 P43246 P622F 622 P F 1 Pathogenic MSH2 P43246 P622G 622 P G 0.698 Pathogenic MSH2 P43246 P622H 622 P H 0.976 Pathogenic MSH2 P43246 P622I 622 P I 0.938 Pathogenic MSH2 P43246 P622K 622 P K 0.946 Pathogenic MSH2 P43246 P622L 622 P L 0.892 Pathogenic 5 MSH2 P43246 P622M 622 P M 0.956 Pathogenic MSH2 P43246 P622N 622 P N 0.574 Pathogenic MSH2 P43246 P622Q 622 P Q 0.878 Pathogenic MSH2 P43246 P622R 622 P R 0.984 Pathogenic MSH2 P43246 P622S 622 P S 0.372 Neutral MSH2 P43246 P622T 622 P T 0.76 Pathogenic MSH2 P43246 P622V 622 P V 0.852 Pathogenic MSH2 P43246 P622W 622 P W 0.936 Pathogenic MSH2 P43246 P622Y 622 P Y 0.932 Pathogenic MSH2 P43246 A623C 623 A C 0.416 Neutral MSH2 P43246 A623D 623 A D 0.792 Pathogenic MSH2 P43246 A623E 623 A E 0.81 Pathogenic MSH2 P43246 A623F 623 A F 0.534 Pathogenic MSH2 P43246 A623G 623 A G 0.46 Neutral MSH2 P43246 A623H 623 A H 0.496 Neutral MSH2 P43246 A623I 623 A I 0.572 Pathogenic MSH2 P43246 A623K 623 A K 0.528 Pathogenic MSH2 P43246 A623L 623 A L 0.536 Pathogenic MSH2 P43246 A623M 623 A M 0.548 Pathogenic MSH2 P43246 A623N 623 A N 0.642 Pathogenic MSH2 P43246 A623P 623 A P 0.828 Pathogenic MSH2 P43246 A623Q 623 A Q 0.478 Neutral MSH2 P43246 A623R 623 A R 0.598 Pathogenic MSH2 P43246 A623S 623 A S 0.01 Neutral MSH2 P43246 A623T 623 A T 0.034 Neutral MSH2 P43246 A623V 623 A V 0.108 Neutral MSH2 P43246 A623W 623 A W 0.922 Pathogenic MSH2 P43246 A623Y 623 A Y 0.594 Pathogenic MSH2 P43246 I624A 624 I A 0.068 Neutral MSH2 P43246 I624C 624 I C 0.352 Neutral MSH2 P43246 I624D 624 I D 0.096 Neutral MSH2 P43246 I624E 624 I E 0.09 Neutral MSH2 P43246 I624F 624 I F 0.626 Pathogenic MSH2 P43246 I624G 624 I G 0.172 Neutral MSH2 P43246 I624H 624 I H 0.294 Neutral MSH2 P43246 I624K 624 I K 0.148 Neutral MSH2 P43246 I624L 624 I L 0.008 Neutral MSH2 P43246 I624M 624 I M 0.444 Neutral MSH2 P43246 I624N 624 I N 0.394 Neutral MSH2 P43246 I624P 624 I P 0.104 Neutral MSH2 P43246 I624Q 624 I Q 0.35 Neutral MSH2 P43246 I624R 624 I R 0.63 Pathogenic MSH2 P43246 I624S 624 I S 0.112 Neutral MSH2 P43246 I624T 624 I T 0.04 Neutral MSH2 P43246 I624V 624 I V 0.07 Neutral MSH2 P43246 I624W 624 I W 0.844 Pathogenic MSH2 P43246 I624Y 624 I Y 0.838 Pathogenic MSH2 P43246 L625A 625 L A 0.054 Neutral MSH2 P43246 L625C 625 L C 0.252 Neutral MSH2 P43246 L625D 625 L D 0.326 Neutral MSH2 P43246 L625E 625 L E 0.53 Pathogenic MSH2 P43246 L625F 625 L F 0.75 Pathogenic MSH2 P43246 L625G 625 L G 0.572 Pathogenic MSH2 P43246 L625H 625 L H 0.062 Neutral MSH2 P43246 L625I 625 L I 0.39 Neutral MSH2 P43246 L625K 625 L K 0.048 Neutral MSH2 P43246 L625M 625 L M 0.036 Neutral MSH2 P43246 L625N 625 L N 0.578 Pathogenic MSH2 P43246 L625P 625 L P 0.178 Neutral MSH2 P43246 L625Q 625 L Q 0.048 Neutral MSH2 P43246 L625R 625 L R 0.512 Pathogenic MSH2 P43246 L625S 625 L S 0.058 Neutral MSH2 P43246 L625T 625 L T 0.054 Neutral MSH2 P43246 L625V 625 L V 0.55 Pathogenic MSH2 P43246 L625W 625 L W 0.81 Pathogenic MSH2 P43246 L625Y 625 L Y 0.832 Pathogenic MSH2 P43246 E626A 626 E A 0.202 Neutral MSH2 P43246 E626C 626 E C 0.414 Neutral MSH2 P43246 E626D 626 E D 0.01 Neutral MSH2 P43246 E626F 626 E F 0.796 Pathogenic MSH2 P43246 E626G 626 E G 0.022 Neutral MSH2 P43246 E626H 626 E H 0.652 Pathogenic MSH2 P43246 E626I 626 E I 0.86 Pathogenic MSH2 P43246 E626K 626 E K 0.354 Neutral MSH2 P43246 E626L 626 E L 0.826 Pathogenic MSH2 P43246 E626M 626 E M 0.656 Pathogenic MSH2 P43246 E626N 626 E N 0.158 Neutral MSH2 P43246 E626P 626 E P 0.448 Neutral MSH2 P43246 E626Q 626 E Q 0.248 Neutral MSH2 P43246 E626R 626 E R 0.442 Neutral MSH2 P43246 E626S 626 E S 0.04 Neutral MSH2 P43246 E626T 626 E T 0.606 Pathogenic MSH2 P43246 E626V 626 E V 0.786 Pathogenic MSH2 P43246 E626W 626 E W 0.934 Pathogenic MSH2 P43246 E626Y 626 E Y 0.86 Pathogenic MSH2 P43246 K627A 627 K A 0.064 Neutral MSH2 P43246 K627C 627 K C 0.05 Neutral MSH2 P43246 K627D 627 K D 0.052 Neutral MSH2 P43246 K627E 627 K E 0.004 Neutral MSH2 P43246 K627F 627 K F 0.35 Neutral MSH2 P43246 K627G 627 K G 0.048 Neutral MSH2 P43246 K627H 627 K H 0.038 Neutral MSH2 P43246 K627I 627 K I 0.354 Neutral MSH2 P43246 K627L 627 K L 0.368 Neutral MSH2 P43246 K627M 627 K M 0.168 Neutral MSH2 P43246 K627N 627 K N 0.116 Neutral MSH2 P43246 K627P 627 K P 0.382 Neutral MSH2 P43246 K627Q 627 K Q 0.01 Neutral MSH2 P43246 K627R 627 K R 0.06 Neutral MSH2 P43246 K627S 627 K S 0.016 Neutral MSH2 P43246 K627T 627 K T 0.016 Neutral MSH2 P43246 K627V 627 K V 0.282 Neutral MSH2 P43246 K627W 627 K W 0.662 Pathogenic MSH2 P43246 K627Y 627 K Y 0.564 Pathogenic MSH2 P43246 G628A 628 G A 0.458 Neutral MSH2 P43246 G628C 628 G C 0.73 Pathogenic MSH2 P43246 G628D 628 G D 0.462 Neutral MSH2 P43246 G628E 628 G E 0.524 Pathogenic MSH2 P43246 G628F 628 G F 0.956 Pathogenic MSH2 P43246 G628H 628 G H 0.95 Pathogenic MSH2 P43246 G628I 628 G I 0.926 Pathogenic MSH2 P43246 G628K 628 G K 0.922 Pathogenic MSH2 P43246 G628L 628 G L 0.93 Pathogenic MSH2 P43246 G628M 628 G M 0.95 Pathogenic MSH2 P43246 G628N 628 G N 0.728 Pathogenic MSH2 P43246 G628P 628 G P 0.914 Pathogenic MSH2 P43246 G628Q 628 G Q 0.794 Pathogenic MSH2 P43246 G628R 628 G R 0.966 Pathogenic MSH2 P43246 G628S 628 G S 0.074 Neutral MSH2 P43246 G628T 628 G T 0.558 Pathogenic MSH2 P43246 G628V 628 G V 0.934 Pathogenic MSH2 P43246 G628W 628 G W 0.946 Pathogenic MSH2 P43246 G628Y 628 G Y 0.934 Pathogenic MSH2 P43246 Q629A 629 Q A 0.044 Neutral MSH2 P43246 Q629C 629 Q C 0.006 Neutral MSH2 P43246 Q629D 629 Q D 0.002 Neutral MSH2 P43246 Q629E 629 Q E 0.006 Neutral MSH2 P43246 Q629F 629 Q F 0.426 Neutral MSH2 P43246 Q629G 629 Q G 0.136 Neutral MSH2 P43246 Q629H 629 Q H 0.096 Neutral MSH2 P43246 Q629I 629 Q I 0.342 Neutral MSH2 P43246 Q629K 629 Q K 0.024 Neutral MSH2 P43246 Q629L 629 Q L 0.394 Neutral MSH2 P43246 Q629M 629 Q M 0.352 Neutral MSH2 P43246 Q629N 629 Q N 0.022 Neutral MSH2 P43246 Q629P 629 Q P 0.246 Neutral MSH2 P43246 Q629R 629 Q R 0.008 Neutral 1 MSH2 P43246 Q629S 629 Q S 0.042 Neutral MSH2 P43246 Q629T 629 Q T 0.004 Neutral MSH2 P43246 Q629V 629 Q V 0.03 Neutral MSH2 P43246 Q629W 629 Q W 0.684 Pathogenic MSH2 P43246 Q629Y 629 Q Y 0.612 Pathogenic MSH2 P43246 V63A 63 V A 0.058 Neutral MSH2 P43246 V63C 63 V C 0.71 Pathogenic MSH2 P43246 V63D 63 V D 0.862 Pathogenic MSH2 P43246 V63E 63 V E 0.978 Pathogenic MSH2 P43246 V63F 63 V F 0.526 Pathogenic MSH2 P43246 V63G 63 V G 0.894 Pathogenic MSH2 P43246 V63H 63 V H 0.82 Pathogenic MSH2 P43246 V63I 63 V I 0.234 Neutral MSH2 P43246 V63K 63 V K 0.99 Pathogenic MSH2 P43246 V63L 63 V L 0.836 Pathogenic MSH2 P43246 V63M 63 V M 0.82 Pathogenic MSH2 P43246 V63N 63 V N 0.256 Neutral MSH2 P43246 V63P 63 V P 0.984 Pathogenic MSH2 P43246 V63Q 63 V Q 0.984 Pathogenic MSH2 P43246 V63R 63 V R 0.952 Pathogenic MSH2 P43246 V63S 63 V S 0.136 Neutral MSH2 P43246 V63T 63 V T 0.746 Pathogenic MSH2 P43246 V63W 63 V W 0.904 Pathogenic MSH2 P43246 V63Y 63 V Y 0.552 Pathogenic MSH2 P43246 G630A 630 G A 0.346 Neutral MSH2 P43246 G630C 630 G C 0.94 Pathogenic MSH2 P43246 G630D 630 G D 0.578 Pathogenic MSH2 P43246 G630E 630 G E 0.984 Pathogenic MSH2 P43246 G630F 630 G F 0.988 Pathogenic MSH2 P43246 G630H 630 G H 0.992 Pathogenic MSH2 P43246 G630I 630 G I 0.978 Pathogenic MSH2 P43246 G630K 630 G K 0.774 Pathogenic MSH2 P43246 G630L 630 G L 0.988 Pathogenic MSH2 P43246 G630M 630 G M 0.996 Pathogenic MSH2 P43246 G630N 630 G N 0.536 Pathogenic MSH2 P43246 G630P 630 G P 0.982 Pathogenic MSH2 P43246 G630Q 630 G Q 0.738 Pathogenic MSH2 P43246 G630R 630 G R 0.646 Pathogenic MSH2 P43246 G630S 630 G S 0.328 Neutral MSH2 P43246 G630T 630 G T 0.66 Pathogenic MSH2 P43246 G630V 630 G V 0.99 Pathogenic MSH2 P43246 G630W 630 G W 0.984 Pathogenic MSH2 P43246 G630Y 630 G Y 0.986 Pathogenic MSH2 P43246 R631A 631 R A 0.372 Neutral MSH2 P43246 R631C 631 R C 0.618 Pathogenic MSH2 P43246 R631D 631 R D 0.036 Neutral MSH2 P43246 R631E 631 R E 0.04 Neutral MSH2 P43246 R631F 631 R F 0.842 Pathogenic MSH2 P43246 R631G 631 R G 0.022 Neutral MSH2 P43246 R631H 631 R H 0.282 Neutral MSH2 P43246 R631I 631 R I 0.168 Neutral MSH2 P43246 R631K 631 R K 0.026 Neutral MSH2 P43246 R631L 631 R L 0.102 Neutral MSH2 P43246 R631M 631 R M 0.614 Pathogenic MSH2 P43246 R631N 631 R N 0.018 Neutral MSH2 P43246 R631P 631 R P 0.734 Pathogenic MSH2 P43246 R631Q 631 R Q 0.02 Neutral MSH2 P43246 R631S 631 R S 0.036 Neutral MSH2 P43246 R631T 631 R T 0.092 Neutral MSH2 P43246 R631V 631 R V 0.1 Neutral MSH2 P43246 R631W 631 R W 0.844 Pathogenic MSH2 P43246 R631Y 631 R Y 0.804 Pathogenic MSH2 P43246 I632A 632 I A 0.46 Neutral MSH2 P43246 I632C 632 I C 0.6 Pathogenic MSH2 P43246 I632D 632 I D 0.774 Pathogenic MSH2 P43246 I632E 632 I E 0.77 Pathogenic MSH2 P43246 I632F 632 I F 0.328 Neutral MSH2 P43246 I632G 632 I G 0.81 Pathogenic MSH2 P43246 I632H 632 I H 0.77 Pathogenic MSH2 P43246 I632K 632 I K 0.81 Pathogenic MSH2 P43246 I632L 632 I L 0.116 Neutral MSH2 P43246 I632M 632 I M 0.142 Neutral MSH2 P43246 I632N 632 I N 0.802 Pathogenic MSH2 P43246 I632P 632 I P 0.866 Pathogenic MSH2 P43246 I632Q 632 I Q 0.798 Pathogenic MSH2 P43246 I632R 632 I R 0.88 Pathogenic MSH2 P43246 I632S 632 I S 0.56 Pathogenic MSH2 P43246 I632T 632 I T 0.122 Neutral MSH2 P43246 I632V 632 I V 0.114 Neutral MSH2 P43246 I632W 632 I W 0.84 Pathogenic MSH2 P43246 I632Y 632 I Y 0.836 Pathogenic MSH2 P43246 I633A 633 I A 0.08 Neutral MSH2 P43246 I633C 633 I C 0.332 Neutral MSH2 P43246 I633D 633 I D 0.158 Neutral MSH2 P43246 I633E 633 I E 0.096 Neutral MSH2 P43246 I633F 633 I F 0.684 Pathogenic MSH2 P43246 I633G 633 I G 0.558 Pathogenic MSH2 P43246 I633H 633 I H 0.064 Neutral MSH2 P43246 I633K 633 I K 0.086 Neutral MSH2 P43246 I633L 633 I L 0.028 Neutral MSH2 P43246 I633M 633 I M 0.102 Neutral MSH2 P43246 I633N 633 I N 0.16 Neutral MSH2 P43246 I633P 633 I P 0.7 Pathogenic MSH2 P43246 I633Q 633 I Q 0.21 Neutral MSH2 P43246 I633R 633 I R 0.56 Pathogenic MSH2 P43246 I633S 633 I S 0.31 Neutral MSH2 P43246 I633T 633 I T 0.038 Neutral MSH2 P43246 I633V 633 I V 0.012 Neutral MSH2 P43246 I633W 633 I W 0.898 Pathogenic MSH2 P43246 I633Y 633 I Y 0.88 Pathogenic MSH2 P43246 L634A 634 L A 0.712 Pathogenic MSH2 P43246 L634C 634 L C 0.822 Pathogenic MSH2 P43246 L634D 634 L D 0.91 Pathogenic MSH2 P43246 L634E 634 L E 0.894 Pathogenic MSH2 P43246 L634F 634 L F 0.812 Pathogenic MSH2 P43246 L634G 634 L G 0.862 Pathogenic MSH2 P43246 L634H 634 L H 0.908 Pathogenic MSH2 P43246 L634I 634 L I 0.452 Neutral MSH2 P43246 L634K 634 L K 0.718 Pathogenic MSH2 P43246 L634M 634 L M 0.608 Pathogenic MSH2 P43246 L634N 634 L N 0.82 Pathogenic MSH2 P43246 L634P 634 L P 0.994 Pathogenic MSH2 P43246 L634Q 634 L Q 0.774 Pathogenic MSH2 P43246 L634R 634 L R 0.984 Pathogenic MSH2 P43246 L634S 634 L S 0.694 Pathogenic MSH2 P43246 L634T 634 L T 0.618 Pathogenic MSH2 P43246 L634V 634 L V 0.282 Neutral MSH2 P43246 L634W 634 L W 0.882 Pathogenic MSH2 P43246 L634Y 634 L Y 0.89 Pathogenic MSH2 P43246 K635A 635 K A 0.24 Neutral MSH2 P43246 K635C 635 K C 0.194 Neutral MSH2 P43246 K635D 635 K D 0.022 Neutral MSH2 P43246 K635E 635 K E 0.018 Neutral MSH2 P43246 K635F 635 K F 0.24 Neutral MSH2 P43246 K635G 635 K G 0.356 Neutral MSH2 P43246 K635H 635 K H 0.074 Neutral MSH2 P43246 K635I 635 K I 0.108 Neutral MSH2 P43246 K635L 635 K L 0.098 Neutral MSH2 P43246 K635M 635 K M 0.586 Pathogenic MSH2 P43246 K635N 635 K N 0.346 Neutral MSH2 P43246 K635P 635 K P 0.832 Pathogenic MSH2 P43246 K635Q 635 K Q 0.036 Neutral MSH2 P43246 K635R 635 K R 0.028 Neutral MSH2 P43246 K635S 635 K S 0.198 Neutral MSH2 P43246 K635T 635 K T 0.038 Neutral MSH2 P43246 K635V 635 K V 0.106 Neutral MSH2 P43246 K635W 635 K W 0.978 Pathogenic MSH2 P43246 K635Y 635 K Y 0.932 Pathogenic MSH2 P43246 A636C 636 A C 0.734 Pathogenic MSH2 P43246 A636D 636 A D 0.684 Pathogenic MSH2 P43246 A636E 636 A E 0.594 Pathogenic MSH2 P43246 A636F 636 A F 0.96 Pathogenic MSH2 P43246 A636G 636 A G 0.014 Neutral MSH2 P43246 A636H 636 A H 0.854 Pathogenic MSH2 P43246 A636I 636 A I 0.926 Pathogenic MSH2 P43246 A636K 636 A K 0.59 Pathogenic MSH2 P43246 A636L 636 A L 0.944 Pathogenic MSH2 P43246 A636M 636 A M 0.816 Pathogenic MSH2 P43246 A636N 636 A N 0.598 Pathogenic MSH2 P43246 A636P 636 A P 0.93 Pathogenic 5 MSH2 P43246 A636Q 636 A Q 0.508 Pathogenic MSH2 P43246 A636R 636 A R 0.906 Pathogenic MSH2 P43246 A636S 636 A S 0.012 Neutral MSH2 P43246 A636T 636 A T 0.636 Pathogenic MSH2 P43246 A636V 636 A V 0.752 Pathogenic MSH2 P43246 A636W 636 A W 0.95 Pathogenic MSH2 P43246 A636Y 636 A Y 0.934 Pathogenic MSH2 P43246 S637A 637 S A 0.14 Neutral MSH2 P43246 S637C 637 S C 0.224 Neutral MSH2 P43246 S637D 637 S D 0.798 Pathogenic MSH2 P43246 S637E 637 S E 0.908 Pathogenic MSH2 P43246 S637F 637 S F 0.978 Pathogenic MSH2 P43246 S637G 637 S G 0.08 Neutral MSH2 P43246 S637H 637 S H 0.922 Pathogenic MSH2 P43246 S637I 637 S I 0.652 Pathogenic MSH2 P43246 S637K 637 S K 0.896 Pathogenic MSH2 P43246 S637L 637 S L 0.51 Pathogenic MSH2 P43246 S637M 637 S M 0.996 Pathogenic MSH2 P43246 S637N 637 S N 0.754 Pathogenic MSH2 P43246 S637P 637 S P 0.916 Pathogenic MSH2 P43246 S637Q 637 S Q 0.868 Pathogenic MSH2 P43246 S637R 637 S R 0.93 Pathogenic MSH2 P43246 S637T 637 S T 0.848 Pathogenic MSH2 P43246 S637V 637 S V 0.31 Neutral MSH2 P43246 S637W 637 S W 0.978 Pathogenic MSH2 P43246 S637Y 637 S Y 0.976 Pathogenic MSH2 P43246 R638A 638 R A 0.574 Pathogenic MSH2 P43246 R638C 638 R C 0.96 Pathogenic MSH2 P43246 R638D 638 R D 0.714 Pathogenic MSH2 P43246 R638E 638 R E 0.814 Pathogenic MSH2 P43246 R638F 638 R F 0.976 Pathogenic MSH2 P43246 R638G 638 R G 0.404 Neutral MSH2 P43246 R638H 638 R H 0.432 Neutral MSH2 P43246 R638I 638 R I 0.98 Pathogenic MSH2 P43246 R638K 638 R K 0.784 Pathogenic MSH2 P43246 R638L 638 R L 0.994 Pathogenic MSH2 P43246 R638M 638 R M 0.8 Pathogenic MSH2 P43246 R638N 638 R N 0.674 Pathogenic MSH2 P43246 R638P 638 R P 0.992 Pathogenic MSH2 P43246 R638Q 638 R Q 0.542 Pathogenic MSH2 P43246 R638S 638 R S 0.924 Pathogenic MSH2 P43246 R638T 638 R T 0.958 Pathogenic MSH2 P43246 R638V 638 R V 0.98 Pathogenic MSH2 P43246 R638W 638 R W 0.96 Pathogenic MSH2 P43246 R638Y 638 R Y 0.97 Pathogenic MSH2 P43246 H639A 639 H A 0.726 Pathogenic MSH2 P43246 H639C 639 H C 0.708 Pathogenic MSH2 P43246 H639D 639 H D 0.664 Pathogenic MSH2 P43246 H639E 639 H E 0.836 Pathogenic MSH2 P43246 H639F 639 H F 0.908 Pathogenic MSH2 P43246 H639G 639 H G 0.512 Pathogenic MSH2 P43246 H639I 639 H I 0.906 Pathogenic MSH2 P43246 H639K 639 H K 0.696 Pathogenic MSH2 P43246 H639L 639 H L 0.758 Pathogenic MSH2 P43246 H639M 639 H M 0.666 Pathogenic MSH2 P43246 H639N 639 H N 0.65 Pathogenic MSH2 P43246 H639P 639 H P 0.99 Pathogenic MSH2 P43246 H639Q 639 H Q 0.842 Pathogenic MSH2 P43246 H639R 639 H R 0.918 Pathogenic MSH2 P43246 H639S 639 H S 0.672 Pathogenic MSH2 P43246 H639T 639 H T 0.592 Pathogenic MSH2 P43246 H639V 639 H V 0.724 Pathogenic MSH2 P43246 H639W 639 H W 0.966 Pathogenic MSH2 P43246 H639Y 639 H Y 0.916 Pathogenic MSH2 P43246 I64A 64 I A 0.218 Neutral MSH2 P43246 I64C 64 I C 0.138 Neutral MSH2 P43246 I64D 64 I D 0.784 Pathogenic MSH2 P43246 I64E 64 I E 0.78 Pathogenic MSH2 P43246 I64F 64 I F 0.802 Pathogenic MSH2 P43246 I64G 64 I G 0.808 Pathogenic MSH2 P43246 I64H 64 I H 0.766 Pathogenic MSH2 P43246 I64K 64 I K 0.826 Pathogenic MSH2 P43246 I64L 64 I L 0.138 Neutral MSH2 P43246 I64M 64 I M 0.15 Neutral MSH2 P43246 I64N 64 I N 0.814 Pathogenic MSH2 P43246 I64P 64 I P 0.884 Pathogenic MSH2 P43246 I64Q 64 I Q 0.814 Pathogenic MSH2 P43246 I64R 64 I R 0.884 Pathogenic MSH2 P43246 I64S 64 I S 0.558 Pathogenic MSH2 P43246 I64T 64 I T 0.36 Neutral MSH2 P43246 I64V 64 I V 0.13 Neutral MSH2 P43246 I64W 64 I W 0.86 Pathogenic MSH2 P43246 I64Y 64 I Y 0.856 Pathogenic MSH2 P43246 A640C 640 A C 0.856 Pathogenic MSH2 P43246 A640D 640 A D 0.926 Pathogenic MSH2 P43246 A640E 640 A E 0.876 Pathogenic MSH2 P43246 A640F 640 A F 0.966 Pathogenic MSH2 P43246 A640G 640 A G 0.756 Pathogenic MSH2 P43246 A640H 640 A H 0.866 Pathogenic MSH2 P43246 A640I 640 A I 0.96 Pathogenic MSH2 P43246 A640K 640 A K 0.936 Pathogenic MSH2 P43246 A640L 640 A L 0.98 Pathogenic MSH2 P43246 A640M 640 A M 0.852 Pathogenic MSH2 P43246 A640N 640 A N 0.862 Pathogenic MSH2 P43246 A640P 640 A P 0.606 Pathogenic MSH2 P43246 A640Q 640 A Q 0.816 Pathogenic MSH2 P43246 A640R 640 A R 0.958 Pathogenic MSH2 P43246 A640S 640 A S 0.42 Neutral MSH2 P43246 A640T 640 A T 0.728 Pathogenic MSH2 P43246 A640V 640 A V 0.91 Pathogenic MSH2 P43246 A640W 640 A W 0.976 Pathogenic MSH2 P43246 A640Y 640 A Y 0.964 Pathogenic MSH2 P43246 C641A 641 C A 0.734 Pathogenic MSH2 P43246 C641D 641 C D 0.96 Pathogenic MSH2 P43246 C641E 641 C E 0.834 Pathogenic MSH2 P43246 C641F 641 C F 0.966 Pathogenic MSH2 P43246 C641G 641 C G 0.926 Pathogenic MSH2 P43246 C641H 641 C H 0.798 Pathogenic MSH2 P43246 C641I 641 C I 0.946 Pathogenic MSH2 P43246 C641K 641 C K 0.874 Pathogenic MSH2 P43246 C641L 641 C L 0.53 Pathogenic MSH2 P43246 C641M 641 C M 0.696 Pathogenic MSH2 P43246 C641N 641 C N 0.434 Neutral MSH2 P43246 C641P 641 C P 0.968 Pathogenic MSH2 P43246 C641Q 641 C Q 0.58 Pathogenic MSH2 P43246 C641R 641 C R 1 Pathogenic MSH2 P43246 C641S 641 C S 0.352 Neutral MSH2 P43246 C641T 641 C T 0.616 Pathogenic MSH2 P43246 C641V 641 C V 0.486 Neutral MSH2 P43246 C641W 641 C W 0.976 Pathogenic MSH2 P43246 C641Y 641 C Y 0.962 Pathogenic MSH2 P43246 V642A 642 V A 0.338 Neutral MSH2 P43246 V642C 642 V C 0.714 Pathogenic MSH2 P43246 V642D 642 V D 0.864 Pathogenic MSH2 P43246 V642E 642 V E 0.982 Pathogenic MSH2 P43246 V642F 642 V F 0.876 Pathogenic MSH2 P43246 V642G 642 V G 0.9 Pathogenic MSH2 P43246 V642H 642 V H 0.82 Pathogenic MSH2 P43246 V642I 642 V I 0.168 Neutral MSH2 P43246 V642K 642 V K 0.984 Pathogenic MSH2 P43246 V642L 642 V L 0.18 Neutral MSH2 P43246 V642M 642 V M 0.226 Neutral MSH2 P43246 V642N 642 V N 0.926 Pathogenic MSH2 P43246 V642P 642 V P 0.982 Pathogenic MSH2 P43246 V642Q 642 V Q 0.99 Pathogenic MSH2 P43246 V642R 642 V R 0.96 Pathogenic MSH2 P43246 V642S 642 V S 0.732 Pathogenic MSH2 P43246 V642T 642 V T 0.75 Pathogenic MSH2 P43246 V642W 642 V W 0.904 Pathogenic MSH2 P43246 V642Y 642 V Y 0.93 Pathogenic MSH2 P43246 E643A 643 E A 0.812 Pathogenic MSH2 P43246 E643C 643 E C 0.77 Pathogenic MSH2 P43246 E643D 643 E D 0.894 Pathogenic MSH2 P43246 E643F 643 E F 0.962 Pathogenic MSH2 P43246 E643G 643 E G 0.342 Neutral MSH2 P43246 E643H 643 E H 0.76 Pathogenic MSH2 P43246 E643I 643 E I 0.98 Pathogenic MSH2 P43246 E643K 643 E K 0.928 Pathogenic MSH2 P43246 E643L 643 E L 0.976 Pathogenic MSH2 P43246 E643M 643 E M 0.92 Pathogenic MSH2 P43246 E643N 643 E N 0.8 Pathogenic MSH2 P43246 E643P 643 E P 0.944 Pathogenic MSH2 P43246 E643Q 643 E Q 0.87 Pathogenic MSH2 P43246 E643R 643 E R 0.936 Pathogenic MSH2 P43246 E643S 643 E S 0.916 Pathogenic MSH2 P43246 E643T 643 E T 0.86 Pathogenic MSH2 P43246 E643V 643 E V 0.926 Pathogenic MSH2 P43246 E643W 643 E W 0.982 Pathogenic MSH2 P43246 E643Y 643 E Y 0.96 Pathogenic MSH2 P43246 V644A 644 V A 0.014 Neutral MSH2 P43246 V644C 644 V C 0.114 Neutral MSH2 P43246 V644D 644 V D 0.616 Pathogenic MSH2 P43246 V644E 644 V E 0.718 Pathogenic MSH2 P43246 V644F 644 V F 0.766 Pathogenic MSH2 P43246 V644G 644 V G 0.46 Neutral MSH2 P43246 V644H 644 V H 0.552 Pathogenic MSH2 P43246 V644I 644 V I 0.082 Neutral MSH2 P43246 V644K 644 V K 0.622 Pathogenic MSH2 P43246 V644L 644 V L 0.048 Neutral MSH2 P43246 V644M 644 V M 0.074 Neutral MSH2 P43246 V644N 644 V N 0.482 Neutral MSH2 P43246 V644P 644 V P 0.86 Pathogenic MSH2 P43246 V644Q 644 V Q 0.252 Neutral MSH2 P43246 V644R 644 V R 0.518 Pathogenic MSH2 P43246 V644S 644 V S 0.464 Neutral MSH2 P43246 V644T 644 V T 0.028 Neutral MSH2 P43246 V644W 644 V W 0.844 Pathogenic MSH2 P43246 V644Y 644 V Y 0.836 Pathogenic MSH2 P43246 Q645A 645 Q A 0.556 Pathogenic MSH2 P43246 Q645C 645 Q C 0.766 Pathogenic MSH2 P43246 Q645D 645 Q D 0.404 Neutral MSH2 P43246 Q645E 645 Q E 0.732 Pathogenic MSH2 P43246 Q645F 645 Q F 0.922 Pathogenic MSH2 P43246 Q645G 645 Q G 0.532 Pathogenic MSH2 P43246 Q645H 645 Q H 0.916 Pathogenic MSH2 P43246 Q645I 645 Q I 0.952 Pathogenic MSH2 P43246 Q645K 645 Q K 0.908 Pathogenic MSH2 P43246 Q645L 645 Q L 0.582 Pathogenic MSH2 P43246 Q645M 645 Q M 0.482 Neutral MSH2 P43246 Q645N 645 Q N 0.9 Pathogenic MSH2 P43246 Q645P 645 Q P 0.916 Pathogenic MSH2 P43246 Q645R 645 Q R 0.926 Pathogenic MSH2 P43246 Q645S 645 Q S 0.668 Pathogenic MSH2 P43246 Q645T 645 Q T 0.482 Neutral MSH2 P43246 Q645V 645 Q V 0.926 Pathogenic MSH2 P43246 Q645W 645 Q W 0.954 Pathogenic MSH2 P43246 Q645Y 645 Q Y 0.942 Pathogenic MSH2 P43246 D646A 646 D A 0.284 Neutral MSH2 P43246 D646C 646 D C 0.848 Pathogenic MSH2 P43246 D646E 646 D E 0.178 Neutral MSH2 P43246 D646F 646 D F 0.972 Pathogenic MSH2 P43246 D646G 646 D G 0.906 Pathogenic MSH2 P43246 D646H 646 D H 0.576 Pathogenic MSH2 P43246 D646I 646 D I 0.964 Pathogenic MSH2 P43246 D646K 646 D K 0.872 Pathogenic MSH2 P43246 D646L 646 D L 0.96 Pathogenic MSH2 P43246 D646M 646 D M 0.94 Pathogenic MSH2 P43246 D646N 646 D N 0.826 Pathogenic MSH2 P43246 D646P 646 D P 0.632 Pathogenic MSH2 P43246 D646Q 646 D Q 0.124 Neutral MSH2 P43246 D646R 646 D R 0.95 Pathogenic MSH2 P43246 D646S 646 D S 0.492 Neutral MSH2 P43246 D646T 646 D T 0.744 Pathogenic MSH2 P43246 D646V 646 D V 0.984 Pathogenic MSH2 P43246 D646W 646 D W 0.976 Pathogenic MSH2 P43246 D646Y 646 D Y 0.966 Pathogenic MSH2 P43246 E647A 647 E A 0.696 Pathogenic MSH2 P43246 E647C 647 E C 0.632 Pathogenic MSH2 P43246 E647D 647 E D 0.112 Neutral MSH2 P43246 E647F 647 E F 0.932 Pathogenic MSH2 P43246 E647G 647 E G 0.098 Neutral MSH2 P43246 E647H 647 E H 0.254 Neutral MSH2 P43246 E647I 647 E I 0.966 Pathogenic MSH2 P43246 E647K 647 E K 0.908 Pathogenic MSH2 P43246 E647L 647 E L 0.954 Pathogenic MSH2 P43246 E647M 647 E M 0.85 Pathogenic MSH2 P43246 E647N 647 E N 0.082 Neutral MSH2 P43246 E647P 647 E P 0.912 Pathogenic MSH2 P43246 E647Q 647 E Q 0.212 Neutral MSH2 P43246 E647R 647 E R 0.818 Pathogenic MSH2 P43246 E647S 647 E S 0.336 Neutral MSH2 P43246 E647T 647 E T 0.816 Pathogenic MSH2 P43246 E647V 647 E V 0.902 Pathogenic MSH2 P43246 E647W 647 E W 0.726 Pathogenic MSH2 P43246 E647Y 647 E Y 0.742 Pathogenic MSH2 P43246 I648A 648 I A 0.526 Pathogenic MSH2 P43246 I648C 648 I C 0.638 Pathogenic MSH2 P43246 I648D 648 I D 0.73 Pathogenic MSH2 P43246 I648E 648 I E 0.742 Pathogenic MSH2 P43246 I648F 648 I F 0.956 Pathogenic MSH2 P43246 I648G 648 I G 0.794 Pathogenic MSH2 P43246 I648H 648 I H 0.888 Pathogenic MSH2 P43246 I648K 648 I K 0.838 Pathogenic MSH2 P43246 I648L 648 I L 0.116 Neutral MSH2 P43246 I648M 648 I M 0.194 Neutral MSH2 P43246 I648N 648 I N 0.756 Pathogenic MSH2 P43246 I648P 648 I P 0.918 Pathogenic MSH2 P43246 I648Q 648 I Q 0.772 Pathogenic MSH2 P43246 I648R 648 I R 0.868 Pathogenic MSH2 P43246 I648S 648 I S 0.372 Neutral MSH2 P43246 I648T 648 I T 0.094 Neutral MSH2 P43246 I648V 648 I V 0.25 Neutral MSH2 P43246 I648W 648 I W 0.984 Pathogenic MSH2 P43246 I648Y 648 I Y 0.97 Pathogenic MSH2 P43246 A649C 649 A C 0.724 Pathogenic MSH2 P43246 A649D 649 A D 0.692 Pathogenic MSH2 P43246 A649E 649 A E 0.838 Pathogenic MSH2 P43246 A649F 649 A F 0.964 Pathogenic MSH2 P43246 A649G 649 A G 0.078 Neutral MSH2 P43246 A649H 649 A H 0.7 Pathogenic MSH2 P43246 A649I 649 A I 0.942 Pathogenic MSH2 P43246 A649K 649 A K 0.872 Pathogenic MSH2 P43246 A649L 649 A L 0.944 Pathogenic MSH2 P43246 A649M 649 A M 0.816 Pathogenic MSH2 P43246 A649N 649 A N 0.586 Pathogenic MSH2 P43246 A649P 649 A P 0.892 Pathogenic MSH2 P43246 A649Q 649 A Q 0.508 Pathogenic MSH2 P43246 A649R 649 A R 0.776 Pathogenic MSH2 P43246 A649S 649 A S 0.014 Neutral MSH2 P43246 A649T 649 A T 0.046 Neutral MSH2 P43246 A649V 649 A V 0.25 Neutral MSH2 P43246 A649W 649 A W 0.95 Pathogenic MSH2 P43246 A649Y 649 A Y 0.94 Pathogenic MSH2 P43246 K65A 65 K A 0.54 Pathogenic MSH2 P43246 K65C 65 K C 0.436 Neutral MSH2 P43246 K65D 65 K D 0.606 Pathogenic MSH2 P43246 K65E 65 K E 0.714 Pathogenic MSH2 P43246 K65F 65 K F 0.964 Pathogenic MSH2 P43246 K65G 65 K G 0.156 Neutral MSH2 P43246 K65H 65 K H 0.09 Neutral MSH2 P43246 K65I 65 K I 0.73 Pathogenic MSH2 P43246 K65L 65 K L 0.978 Pathogenic MSH2 P43246 K65M 65 K M 0.922 Pathogenic MSH2 P43246 K65N 65 K N 0.652 Pathogenic MSH2 P43246 K65P 65 K P 0.922 Pathogenic MSH2 P43246 K65Q 65 K Q 0.724 Pathogenic MSH2 P43246 K65R 65 K R 0.094 Neutral MSH2 P43246 K65S 65 K S 0.72 Pathogenic MSH2 P43246 K65T 65 K T 0.126 Neutral MSH2 P43246 K65V 65 K V 0.878 Pathogenic MSH2 P43246 K65W 65 K W 0.992 Pathogenic MSH2 P43246 K65Y 65 K Y 0.984 Pathogenic MSH2 P43246 F650A 650 F A 0.498 Neutral MSH2 P43246 F650C 650 F C 0.728 Pathogenic MSH2 P43246 F650D 650 F D 0.816 Pathogenic MSH2 P43246 F650E 650 F E 0.87 Pathogenic MSH2 P43246 F650G 650 F G 0.506 Pathogenic MSH2 P43246 F650H 650 F H 0.772 Pathogenic MSH2 P43246 F650I 650 F I 0.688 Pathogenic MSH2 P43246 F650K 650 F K 0.85 Pathogenic MSH2 P43246 F650L 650 F L 0.422 Neutral MSH2 P43246 F650M 650 F M 0.788 Pathogenic MSH2 P43246 F650N 650 F N 0.766 Pathogenic MSH2 P43246 F650P 650 F P 0.952 Pathogenic MSH2 P43246 F650Q 650 F Q 0.788 Pathogenic MSH2 P43246 F650R 650 F R 0.918 Pathogenic MSH2 P43246 F650S 650 F S 0.868 Pathogenic MSH2 P43246 F650T 650 F T 0.59 Pathogenic MSH2 P43246 F650V 650 F V 0.462 Neutral MSH2 P43246 F650W 650 F W 0.868 Pathogenic MSH2 P43246 F650Y 650 F Y 0.428 Neutral MSH2 P43246 I651A 651 I A 0.652 Pathogenic MSH2 P43246 I651C 651 I C 0.748 Pathogenic MSH2 P43246 I651D 651 I D 0.818 Pathogenic MSH2 P43246 I651E 651 I E 0.816 Pathogenic MSH2 P43246 I651F 651 I F 0.852 Pathogenic MSH2 P43246 I651G 651 I G 0.872 Pathogenic MSH2 P43246 I651H 651 I H 0.91 Pathogenic MSH2 P43246 I651K 651 I K 0.852 Pathogenic MSH2 P43246 I651L 651 I L 0.598 Pathogenic MSH2 P43246 I651M 651 I M 0.53 Pathogenic MSH2 P43246 I651N 651 I N 0.84 Pathogenic MSH2 P43246 I651P 651 I P 0.936 Pathogenic MSH2 P43246 I651Q 651 I Q 0.844 Pathogenic MSH2 P43246 I651R 651 I R 0.9 Pathogenic MSH2 P43246 I651S 651 I S 0.732 Pathogenic MSH2 P43246 I651T 651 I T 0.372 Neutral MSH2 P43246 I651V 651 I V 0.412 Neutral MSH2 P43246 I651W 651 I W 0.904 Pathogenic MSH2 P43246 I651Y 651 I Y 0.88 Pathogenic MSH2 P43246 P652A 652 P A 0.17 Neutral MSH2 P43246 P652C 652 P C 0.904 Pathogenic MSH2 P43246 P652D 652 P D 0.792 Pathogenic MSH2 P43246 P652E 652 P E 0.606 Pathogenic MSH2 P43246 P652F 652 P F 0.998 Pathogenic MSH2 P43246 P652G 652 P G 0.518 Pathogenic MSH2 P43246 P652H 652 P H 0.982 Pathogenic 4 MSH2 P43246 P652I 652 P I 0.93 Pathogenic MSH2 P43246 P652K 652 P K 0.96 Pathogenic MSH2 P43246 P652L 652 P L 0.988 Pathogenic MSH2 P43246 P652M 652 P M 0.964 Pathogenic MSH2 P43246 P652N 652 P N 0.646 Pathogenic MSH2 P43246 P652Q 652 P Q 0.858 Pathogenic MSH2 P43246 P652R 652 P R 0.986 Pathogenic MSH2 P43246 P652S 652 P S 0.094 Neutral MSH2 P43246 P652T 652 P T 0.13 Neutral MSH2 P43246 P652V 652 P V 0.836 Pathogenic MSH2 P43246 P652W 652 P W 0.946 Pathogenic MSH2 P43246 P652Y 652 P Y 0.946 Pathogenic MSH2 P43246 N653A 653 N A 0.802 Pathogenic MSH2 P43246 N653C 653 N C 0.782 Pathogenic MSH2 P43246 N653D 653 N D 0.748 Pathogenic MSH2 P43246 N653E 653 N E 0.63 Pathogenic MSH2 P43246 N653F 653 N F 0.96 Pathogenic MSH2 P43246 N653G 653 N G 0.738 Pathogenic MSH2 P43246 N653H 653 N H 0.876 Pathogenic MSH2 P43246 N653I 653 N I 0.948 Pathogenic MSH2 P43246 N653K 653 N K 0.94 Pathogenic MSH2 P43246 N653L 653 N L 0.964 Pathogenic MSH2 P43246 N653M 653 N M 0.962 Pathogenic MSH2 P43246 N653P 653 N P 0.874 Pathogenic MSH2 P43246 N653Q 653 N Q 0.816 Pathogenic MSH2 P43246 N653R 653 N R 0.95 Pathogenic MSH2 P43246 N653S 653 N S 0.432 Neutral MSH2 P43246 N653T 653 N T 0.552 Pathogenic MSH2 P43246 N653V 653 N V 0.99 Pathogenic MSH2 P43246 N653W 653 N W 0.974 Pathogenic MSH2 P43246 N653Y 653 N Y 0.97 Pathogenic MSH2 P43246 D654A 654 D A 0.784 Pathogenic MSH2 P43246 D654C 654 D C 0.876 Pathogenic MSH2 P43246 D654E 654 D E 0.572 Pathogenic MSH2 P43246 D654F 654 D F 0.98 Pathogenic MSH2 P43246 D654G 654 D G 0.932 Pathogenic MSH2 P43246 D654H 654 D H 0.648 Pathogenic MSH2 P43246 D654I 654 D I 0.972 Pathogenic MSH2 P43246 D654K 654 D K 0.904 Pathogenic MSH2 P43246 D654L 654 D L 0.976 Pathogenic MSH2 P43246 D654M 654 D M 0.952 Pathogenic MSH2 P43246 D654N 654 D N 0.364 Neutral MSH2 P43246 D654P 654 D P 0.894 Pathogenic MSH2 P43246 D654Q 654 D Q 0.594 Pathogenic MSH2 P43246 D654R 654 D R 0.958 Pathogenic MSH2 P43246 D654S 654 D S 0.28 Neutral MSH2 P43246 D654T 654 D T 0.5 Pathogenic MSH2 P43246 D654V 654 D V 0.992 Pathogenic MSH2 P43246 D654W 654 D W 0.982 Pathogenic MSH2 P43246 D654Y 654 D Y 0.974 Pathogenic MSH2 P43246 V655A 655 V A 0.064 Neutral MSH2 P43246 V655C 655 V C 0.11 Neutral MSH2 P43246 V655D 655 V D 0.862 Pathogenic MSH2 P43246 V655E 655 V E 0.978 Pathogenic MSH2 P43246 V655F 655 V F 0.876 Pathogenic MSH2 P43246 V655G 655 V G 0.894 Pathogenic MSH2 P43246 V655H 655 V H 0.278 Neutral MSH2 P43246 V655I 655 V I 0.158 Neutral 2 MSH2 P43246 V655K 655 V K 0.99 Pathogenic MSH2 P43246 V655L 655 V L 0.336 Neutral MSH2 P43246 V655M 655 V M 0.82 Pathogenic MSH2 P43246 V655N 655 V N 0.922 Pathogenic MSH2 P43246 V655P 655 V P 0.984 Pathogenic MSH2 P43246 V655Q 655 V Q 0.984 Pathogenic MSH2 P43246 V655R 655 V R 0.952 Pathogenic MSH2 P43246 V655S 655 V S 0.72 Pathogenic MSH2 P43246 V655T 655 V T 0.104 Neutral MSH2 P43246 V655W 655 V W 0.904 Pathogenic MSH2 P43246 V655Y 655 V Y 0.928 Pathogenic MSH2 P43246 Y656A 656 Y A 0.124 Neutral MSH2 P43246 Y656C 656 Y C 0.31 Neutral MSH2 P43246 Y656D 656 Y D 0.104 Neutral MSH2 P43246 Y656E 656 Y E 0.1 Neutral MSH2 P43246 Y656F 656 Y F 0.276 Neutral MSH2 P43246 Y656G 656 Y G 0.274 Neutral MSH2 P43246 Y656H 656 Y H 0.05 Neutral MSH2 P43246 Y656I 656 Y I 0.076 Neutral MSH2 P43246 Y656K 656 Y K 0.076 Neutral MSH2 P43246 Y656L 656 Y L 0.066 Neutral MSH2 P43246 Y656M 656 Y M 0.108 Neutral MSH2 P43246 Y656N 656 Y N 0.136 Neutral MSH2 P43246 Y656P 656 Y P 0.316 Neutral MSH2 P43246 Y656Q 656 Y Q 0.168 Neutral MSH2 P43246 Y656R 656 Y R 0.104 Neutral MSH2 P43246 Y656S 656 Y S 0.168 Neutral MSH2 P43246 Y656T 656 Y T 0.134 Neutral MSH2 P43246 Y656V 656 Y V 0.072 Neutral MSH2 P43246 Y656W 656 Y W 0.304 Neutral MSH2 P43246 F657A 657 F A 0.426 Neutral MSH2 P43246 F657C 657 F C 0.58 Pathogenic MSH2 P43246 F657D 657 F D 0.764 Pathogenic MSH2 P43246 F657E 657 F E 0.848 Pathogenic MSH2 P43246 F657G 657 F G 0.478 Neutral MSH2 P43246 F657H 657 F H 0.634 Pathogenic MSH2 P43246 F657I 657 F I 0.566 Pathogenic MSH2 P43246 F657K 657 F K 0.832 Pathogenic MSH2 P43246 F657L 657 F L 0.14 Neutral MSH2 P43246 F657M 657 F M 0.102 Neutral MSH2 P43246 F657N 657 F N 0.684 Pathogenic MSH2 P43246 F657P 657 F P 0.936 Pathogenic MSH2 P43246 F657Q 657 F Q 0.716 Pathogenic MSH2 P43246 F657R 657 F R 0.904 Pathogenic MSH2 P43246 F657S 657 F S 0.756 Pathogenic MSH2 P43246 F657T 657 F T 0.572 Pathogenic MSH2 P43246 F657V 657 F V 0.834 Pathogenic MSH2 P43246 F657W 657 F W 0.944 Pathogenic MSH2 P43246 F657Y 657 F Y 0.706 Pathogenic MSH2 P43246 E658A 658 E A 0.286 Neutral MSH2 P43246 E658C 658 E C 0.422 Neutral MSH2 P43246 E658D 658 E D 0.044 Neutral MSH2 P43246 E658F 658 E F 0.822 Pathogenic MSH2 P43246 E658G 658 E G 0.17 Neutral MSH2 P43246 E658H 658 E H 0.666 Pathogenic MSH2 P43246 E658I 658 E I 0.23 Neutral MSH2 P43246 E658K 658 E K 0.064 Neutral MSH2 P43246 E658L 658 E L 0.314 Neutral MSH2 P43246 E658M 658 E M 0.688 Pathogenic MSH2 P43246 E658N 658 E N 0.078 Neutral MSH2 P43246 E658P 658 E P 0.86 Pathogenic MSH2 P43246 E658Q 658 E Q 0.156 Neutral MSH2 P43246 E658R 658 E R 0.16 Neutral MSH2 P43246 E658S 658 E S 0.252 Neutral MSH2 P43246 E658T 658 E T 0.064 Neutral MSH2 P43246 E658V 658 E V 0.122 Neutral MSH2 P43246 E658W 658 E W 0.952 Pathogenic MSH2 P43246 E658Y 658 E Y 0.89 Pathogenic MSH2 P43246 K659A 659 K A 0.16 Neutral MSH2 P43246 K659C 659 K C 0.434 Neutral MSH2 P43246 K659D 659 K D 0.234 Neutral MSH2 P43246 K659E 659 K E 0.272 Neutral MSH2 P43246 K659F 659 K F 0.964 Pathogenic MSH2 P43246 K659G 659 K G 0.534 Pathogenic MSH2 P43246 K659H 659 K H 0.26 Neutral MSH2 P43246 K659I 659 K I 0.738 Pathogenic MSH2 P43246 K659L 659 K L 0.978 Pathogenic MSH2 P43246 K659M 659 K M 0.922 Pathogenic MSH2 P43246 K659N 659 K N 0.162 Neutral MSH2 P43246 K659P 659 K P 0.426 Neutral MSH2 P43246 K659Q 659 K Q 0.11 Neutral MSH2 P43246 K659R 659 K R 0.112 Neutral MSH2 P43246 K659S 659 K S 0.144 Neutral MSH2 P43246 K659T 659 K T 0.62 Pathogenic MSH2 P43246 K659V 659 K V 0.878 Pathogenic MSH2 P43246 K659W 659 K W 0.992 Pathogenic MSH2 P43246 K659Y 659 K Y 0.984 Pathogenic MSH2 P43246 Y66A 66 Y A 0.126 Neutral MSH2 P43246 Y66C 66 Y C 0.326 Neutral MSH2 P43246 Y66D 66 Y D 0.11 Neutral MSH2 P43246 Y66E 66 Y E 0.106 Neutral MSH2 P43246 Y66F 66 Y F 0.04 Neutral MSH2 P43246 Y66G 66 Y G 0.286 Neutral MSH2 P43246 Y66H 66 Y H 0.044 Neutral MSH2 P43246 Y66I 66 Y I 0.08 Neutral MSH2 P43246 Y66K 66 Y K 0.078 Neutral MSH2 P43246 Y66L 66 Y L 0.272 Neutral MSH2 P43246 Y66M 66 Y M 0.058 Neutral MSH2 P43246 Y66N 66 Y N 0.14 Neutral MSH2 P43246 Y66P 66 Y P 0.342 Neutral MSH2 P43246 Y66Q 66 Y Q 0.126 Neutral MSH2 P43246 Y66R 66 Y R 0.336 Neutral MSH2 P43246 Y66S 66 Y S 0.23 Neutral MSH2 P43246 Y66T 66 Y T 0.14 Neutral MSH2 P43246 Y66V 66 Y V 0.558 Pathogenic MSH2 P43246 Y66W 66 Y W 0.292 Neutral MSH2 P43246 D660A 660 D A 0.072 Neutral MSH2 P43246 D660C 660 D C 0.156 Neutral MSH2 P43246 D660E 660 D E 0.014 Neutral MSH2 P43246 D660F 660 D F 0.44 Neutral MSH2 P43246 D660G 660 D G 0.018 Neutral MSH2 P43246 D660H 660 D H 0.098 Neutral MSH2 P43246 D660I 660 D I 0.288 Neutral MSH2 P43246 D660K 660 D K 0.184 Neutral MSH2 P43246 D660L 660 D L 0.284 Neutral MSH2 P43246 D660M 660 D M 0.212 Neutral MSH2 P43246 D660N 660 D N 0 Neutral MSH2 P43246 D660P 660 D P 0.306 Neutral MSH2 P43246 D660Q 660 D Q 0.116 Neutral MSH2 P43246 D660R 660 D R 0.184 Neutral MSH2 P43246 D660S 660 D S 0.15 Neutral MSH2 P43246 D660T 660 D T 0.12 Neutral MSH2 P43246 D660V 660 D V 0.288 Neutral MSH2 P43246 D660W 660 D W 0.514 Pathogenic MSH2 P43246 D660Y 660 D Y 0.48 Neutral MSH2 P43246 K661A 661 K A 0.16 Neutral MSH2 P43246 K661C 661 K C 0.206 Neutral MSH2 P43246 K661D 661 K D 0.008 Neutral MSH2 P43246 K661E 661 K E 0.016 Neutral MSH2 P43246 K661F 661 K F 0.844 Pathogenic MSH2 P43246 K661G 661 K G 0.094 Neutral MSH2 P43246 K661H 661 K H 0.404 Neutral MSH2 P43246 K661I 661 K I 0.894 Pathogenic MSH2 P43246 K661L 661 K L 0.668 Pathogenic MSH2 P43246 K661M 661 K M 0.656 Pathogenic MSH2 P43246 K661N 661 K N 0.024 Neutral MSH2 P43246 K661P 661 K P 0.832 Pathogenic MSH2 P43246 K661Q 661 K Q 0.032 Neutral MSH2 P43246 K661R 661 K R 0.086 Neutral MSH2 P43246 K661S 661 K S 0.028 Neutral MSH2 P43246 K661T 661 K T 0.28 Neutral MSH2 P43246 K661V 661 K V 0.78 Pathogenic MSH2 P43246 K661W 661 K W 0.974 Pathogenic MSH2 P43246 K661Y 661 K Y 0.928 Pathogenic MSH2 P43246 Q662A 662 Q A 0.146 Neutral MSH2 P43246 Q662C 662 Q C 0.438 Neutral MSH2 P43246 Q662D 662 Q D 0.03 Neutral MSH2 P43246 Q662E 662 Q E 0.034 Neutral MSH2 P43246 Q662F 662 Q F 0.82 Pathogenic MSH2 P43246 Q662G 662 Q G 0.138 Neutral MSH2 P43246 Q662H 662 Q H 0.436 Neutral MSH2 P43246 Q662I 662 Q I 0.87 Pathogenic MSH2 P43246 Q662K 662 Q K 0.056 Neutral MSH2 P43246 Q662L 662 Q L 0.75 Pathogenic MSH2 P43246 Q662M 662 Q M 0.722 Pathogenic MSH2 P43246 Q662N 662 Q N 0.526 Pathogenic MSH2 P43246 Q662P 662 Q P 0.844 Pathogenic MSH2 P43246 Q662R 662 Q R 0.148 Neutral MSH2 P43246 Q662S 662 Q S 0.094 Neutral MSH2 P43246 Q662T 662 Q T 0.042 Neutral MSH2 P43246 Q662V 662 Q V 0.096 Neutral MSH2 P43246 Q662W 662 Q W 0.93 Pathogenic MSH2 P43246 Q662Y 662 Q Y 0.918 Pathogenic MSH2 P43246 M663A 663 M A 0.26 Neutral MSH2 P43246 M663C 663 M C 0.172 Neutral MSH2 P43246 M663D 663 M D 0.112 Neutral MSH2 P43246 M663E 663 M E 0.034 Neutral MSH2 P43246 M663F 663 M F 0.722 Pathogenic MSH2 P43246 M663G 663 M G 0.362 Neutral MSH2 P43246 M663H 663 M H 0.054 Neutral MSH2 P43246 M663I 663 M I 0.518 Pathogenic MSH2 P43246 M663K 663 M K 0.504 Pathogenic MSH2 P43246 M663L 663 M L 0.422 Neutral MSH2 P43246 M663N 663 M N 0.102 Neutral MSH2 P43246 M663P 663 M P 0.854 Pathogenic MSH2 P43246 M663Q 663 M Q 0.038 Neutral MSH2 P43246 M663R 663 M R 0.09 Neutral MSH2 P43246 M663S 663 M S 0.03 Neutral MSH2 P43246 M663T 663 M T 0.028 Neutral MSH2 P43246 M663V 663 M V 0.352 Neutral MSH2 P43246 M663W 663 M W 0.534 Pathogenic MSH2 P43246 M663Y 663 M Y 0.838 Pathogenic MSH2 P43246 F664A 664 F A 0.502 Pathogenic MSH2 P43246 F664C 664 F C 0.732 Pathogenic MSH2 P43246 F664D 664 F D 0.822 Pathogenic MSH2 P43246 F664E 664 F E 0.872 Pathogenic MSH2 P43246 F664G 664 F G 0.518 Pathogenic MSH2 P43246 F664H 664 F H 0.77 Pathogenic MSH2 P43246 F664I 664 F I 0.68 Pathogenic MSH2 P43246 F664K 664 F K 0.85 Pathogenic MSH2 P43246 F664L 664 F L 0.352 Neutral MSH2 P43246 F664M 664 F M 0.352 Neutral MSH2 P43246 F664N 664 F N 0.772 Pathogenic MSH2 P43246 F664P 664 F P 0.958 Pathogenic MSH2 P43246 F664Q 664 F Q 0.79 Pathogenic MSH2 P43246 F664R 664 F R 0.92 Pathogenic MSH2 P43246 F664S 664 F S 0.888 Pathogenic MSH2 P43246 F664T 664 F T 0.386 Neutral MSH2 P43246 F664V 664 F V 0.74 Pathogenic MSH2 P43246 F664W 664 F W 0.864 Pathogenic MSH2 P43246 F664Y 664 F Y 0.552 Pathogenic MSH2 P43246 H665A 665 H A 0.216 Neutral MSH2 P43246 H665C 665 H C 0.02 Neutral MSH2 P43246 H665D 665 H D 0.26 Neutral MSH2 P43246 H665E 665 H E 0.374 Neutral MSH2 P43246 H665F 665 H F 0.108 Neutral MSH2 P43246 H665G 665 H G 0.316 Neutral MSH2 P43246 H665I 665 H I 0.106 Neutral MSH2 P43246 H665K 665 H K 0.598 Pathogenic MSH2 P43246 H665L 665 H L 0.082 Neutral MSH2 P43246 H665M 665 H M 0.62 Pathogenic MSH2 P43246 H665N 665 H N 0.216 Neutral MSH2 P43246 H665P 665 H P 0.906 Pathogenic MSH2 P43246 H665Q 665 H Q 0.016 Neutral MSH2 P43246 H665R 665 H R 0.074 Neutral MSH2 P43246 H665S 665 H S 0.372 Neutral MSH2 P43246 H665T 665 H T 0.454 Neutral MSH2 P43246 H665V 665 H V 0.446 Neutral MSH2 P43246 H665W 665 H W 0.948 Pathogenic MSH2 P43246 H665Y 665 H Y 0.104 Neutral MSH2 P43246 I666A 666 I A 0.648 Pathogenic MSH2 P43246 I666C 666 I C 0.538 Pathogenic MSH2 P43246 I666D 666 I D 0.812 Pathogenic MSH2 P43246 I666E 666 I E 0.814 Pathogenic MSH2 P43246 I666F 666 I F 0.594 Pathogenic MSH2 P43246 I666G 666 I G 0.874 Pathogenic MSH2 P43246 I666H 666 I H 0.91 Pathogenic MSH2 P43246 I666K 666 I K 0.854 Pathogenic MSH2 P43246 I666L 666 I L 0.296 Neutral MSH2 P43246 I666M 666 I M 0.67 Pathogenic MSH2 P43246 I666N 666 I N 0.834 Pathogenic MSH2 P43246 I666P 666 I P 0.932 Pathogenic MSH2 P43246 I666Q 666 I Q 0.842 Pathogenic MSH2 P43246 I666R 666 I R 0.904 Pathogenic MSH2 P43246 I666S 666 I S 0.72 Pathogenic MSH2 P43246 I666T 666 I T 0.342 Neutral MSH2 P43246 I666V 666 I V 0.284 Neutral MSH2 P43246 I666W 666 I W 0.896 Pathogenic MSH2 P43246 I666Y 666 I Y 0.872 Pathogenic MSH2 P43246 I667A 667 I A 0.648 Pathogenic MSH2 P43246 I667C 667 I C 0.738 Pathogenic MSH2 P43246 I667D 667 I D 0.812 Pathogenic MSH2 P43246 I667E 667 I E 0.814 Pathogenic MSH2 P43246 I667F 667 I F 0.846 Pathogenic MSH2 P43246 I667G 667 I G 0.874 Pathogenic MSH2 P43246 I667H 667 I H 0.91 Pathogenic MSH2 P43246 I667K 667 I K 0.652 Pathogenic MSH2 P43246 I667L 667 I L 0.312 Neutral MSH2 P43246 I667M 667 I M 0.672 Pathogenic MSH2 P43246 I667N 667 I N 0.834 Pathogenic MSH2 P43246 I667P 667 I P 0.932 Pathogenic MSH2 P43246 I667Q 667 I Q 0.842 Pathogenic MSH2 P43246 I667R 667 I R 0.904 Pathogenic MSH2 P43246 I667S 667 I S 0.72 Pathogenic MSH2 P43246 I667T 667 I T 0.35 Neutral MSH2 P43246 I667V 667 I V 0.272 Neutral MSH2 P43246 I667W 667 I W 0.898 Pathogenic MSH2 P43246 I667Y 667 I Y 0.874 Pathogenic MSH2 P43246 T668A 668 T A 0.718 Pathogenic MSH2 P43246 T668C 668 T C 0.942 Pathogenic MSH2 P43246 T668D 668 T D 0.956 Pathogenic MSH2 P43246 T668E 668 T E 0.952 Pathogenic MSH2 P43246 T668F 668 T F 0.95 Pathogenic MSH2 P43246 T668G 668 T G 0.754 Pathogenic MSH2 P43246 T668H 668 T H 0.926 Pathogenic MSH2 P43246 T668I 668 T I 0.952 Pathogenic MSH2 P43246 T668K 668 T K 0.94 Pathogenic MSH2 P43246 T668L 668 T L 0.722 Pathogenic MSH2 P43246 T668M 668 T M 0.816 Pathogenic MSH2 P43246 T668N 668 T N 0.904 Pathogenic MSH2 P43246 T668P 668 T P 0.968 Pathogenic MSH2 P43246 T668Q 668 T Q 0.894 Pathogenic MSH2 P43246 T668R 668 T R 0.994 Pathogenic MSH2 P43246 T668S 668 T S 0.504 Pathogenic MSH2 P43246 T668V 668 T V 0.762 Pathogenic MSH2 P43246 T668W 668 T W 0.978 Pathogenic MSH2 P43246 T668Y 668 T Y 0.978 Pathogenic MSH2 P43246 G669A 669 G A 0.966 Pathogenic MSH2 P43246 G669C 669 G C 0.948 Pathogenic MSH2 P43246 G669D 669 G D 1 Pathogenic MSH2 P43246 G669E 669 G E 0.988 Pathogenic MSH2 P43246 G669F 669 G F 0.984 Pathogenic MSH2 P43246 G669H 669 G H 0.988 Pathogenic MSH2 P43246 G669I 669 G I 0.974 Pathogenic MSH2 P43246 G669K 669 G K 0.988 Pathogenic MSH2 P43246 G669L 669 G L 0.984 Pathogenic MSH2 P43246 G669M 669 G M 0.994 Pathogenic MSH2 P43246 G669N 669 G N 0.986 Pathogenic MSH2 P43246 G669P 669 G P 0.966 Pathogenic MSH2 P43246 G669Q 669 G Q 0.994 Pathogenic MSH2 P43246 G669R 669 G R 1 Pathogenic 4 MSH2 P43246 G669S 669 G S 0.674 Pathogenic MSH2 P43246 G669T 669 G T 0.846 Pathogenic MSH2 P43246 G669V 669 G V 0.986 Pathogenic MSH2 P43246 G669W 669 G W 0.98 Pathogenic MSH2 P43246 G669Y 669 G Y 0.96 Pathogenic MSH2 P43246 M67A 67 M A 0.194 Neutral MSH2 P43246 M67C 67 M C 0.076 Neutral MSH2 P43246 M67D 67 M D 0.872 Pathogenic MSH2 P43246 M67E 67 M E 0.678 Pathogenic MSH2 P43246 M67F 67 M F 0.502 Pathogenic MSH2 P43246 M67G 67 M G 0.536 Pathogenic MSH2 P43246 M67H 67 M H 0.728 Pathogenic MSH2 P43246 M67I 67 M I 0.21 Neutral MSH2 P43246 M67K 67 M K 0.826 Pathogenic MSH2 P43246 M67L 67 M L 0.198 Neutral MSH2 P43246 M67N 67 M N 0.932 Pathogenic MSH2 P43246 M67P 67 M P 0.896 Pathogenic MSH2 P43246 M67Q 67 M Q 0.636 Pathogenic MSH2 P43246 M67R 67 M R 0.94 Pathogenic MSH2 P43246 M67S 67 M S 0.384 Neutral MSH2 P43246 M67T 67 M T 0.348 Neutral MSH2 P43246 M67V 67 M V 0.494 Neutral MSH2 P43246 M67W 67 M W 0.66 Pathogenic MSH2 P43246 M67Y 67 M Y 0.446 Neutral MSH2 P43246 P670A 670 P A 0.472 Neutral MSH2 P43246 P670C 670 P C 0.922 Pathogenic MSH2 P43246 P670D 670 P D 0.874 Pathogenic MSH2 P43246 P670E 670 P E 0.956 Pathogenic MSH2 P43246 P670F 670 P F 1 Pathogenic MSH2 P43246 P670G 670 P G 0.698 Pathogenic MSH2 P43246 P670H 670 P H 0.976 Pathogenic MSH2 P43246 P670I 670 P I 0.938 Pathogenic MSH2 P43246 P670K 670 P K 0.946 Pathogenic MSH2 P43246 P670L 670 P L 0.998 Pathogenic MSH2 P43246 P670M 670 P M 0.956 Pathogenic MSH2 P43246 P670N 670 P N 0.796 Pathogenic MSH2 P43246 P670Q 670 P Q 0.878 Pathogenic MSH2 P43246 P670R 670 P R 0.984 Pathogenic MSH2 P43246 P670S 670 P S 0.372 Neutral MSH2 P43246 P670T 670 P T 0.76 Pathogenic MSH2 P43246 P670V 670 P V 0.852 Pathogenic MSH2 P43246 P670W 670 P W 0.936 Pathogenic MSH2 P43246 P670Y 670 P Y 0.932 Pathogenic MSH2 P43246 N671A 671 N A 0.802 Pathogenic MSH2 P43246 N671C 671 N C 0.672 Pathogenic MSH2 P43246 N671D 671 N D 0.748 Pathogenic MSH2 P43246 N671E 671 N E 0.63 Pathogenic MSH2 P43246 N671F 671 N F 0.96 Pathogenic MSH2 P43246 N671G 671 N G 0.738 Pathogenic MSH2 P43246 N671H 671 N H 0.876 Pathogenic MSH2 P43246 N671I 671 N I 0.948 Pathogenic MSH2 P43246 N671K 671 N K 0.94 Pathogenic MSH2 P43246 N671L 671 N L 0.964 Pathogenic MSH2 P43246 N671M 671 N M 0.962 Pathogenic MSH2 P43246 N671P 671 N P 0.874 Pathogenic MSH2 P43246 N671Q 671 N Q 0.816 Pathogenic MSH2 P43246 N671R 671 N R 0.95 Pathogenic MSH2 P43246 N671S 671 N S 0.432 Neutral MSH2 P43246 N671T 671 N T 0.552 Pathogenic MSH2 P43246 N671V 671 N V 0.99 Pathogenic MSH2 P43246 N671W 671 N W 0.974 Pathogenic MSH2 P43246 N671Y 671 N Y 0.97 Pathogenic MSH2 P43246 M672A 672 M A 0.438 Neutral MSH2 P43246 M672C 672 M C 0.408 Neutral MSH2 P43246 M672D 672 M D 0.892 Pathogenic MSH2 P43246 M672E 672 M E 0.846 Pathogenic MSH2 P43246 M672F 672 M F 0.82 Pathogenic MSH2 P43246 M672G 672 M G 0.524 Pathogenic MSH2 P43246 M672H 672 M H 0.956 Pathogenic MSH2 P43246 M672I 672 M I 0.856 Pathogenic MSH2 P43246 M672K 672 M K 0.966 Pathogenic MSH2 P43246 M672L 672 M L 0.84 Pathogenic MSH2 P43246 M672N 672 M N 0.914 Pathogenic MSH2 P43246 M672P 672 M P 0.932 Pathogenic MSH2 P43246 M672Q 672 M Q 0.812 Pathogenic MSH2 P43246 M672R 672 M R 0.962 Pathogenic MSH2 P43246 M672S 672 M S 0.908 Pathogenic MSH2 P43246 M672T 672 M T 0.52 Pathogenic MSH2 P43246 M672V 672 M V 0.65 Pathogenic MSH2 P43246 M672W 672 M W 0.97 Pathogenic MSH2 P43246 M672Y 672 M Y 0.964 Pathogenic MSH2 P43246 G673A 673 G A 0.768 Pathogenic MSH2 P43246 G673C 673 G C 0.832 Pathogenic MSH2 P43246 G673D 673 G D 1 Pathogenic MSH2 P43246 G673E 673 G E 0.874 Pathogenic MSH2 P43246 G673F 673 G F 0.984 Pathogenic MSH2 P43246 G673H 673 G H 0.988 Pathogenic MSH2 P43246 G673I 673 G I 0.974 Pathogenic MSH2 P43246 G673K 673 G K 0.988 Pathogenic MSH2 P43246 G673L 673 G L 0.984 Pathogenic MSH2 P43246 G673M 673 G M 0.994 Pathogenic MSH2 P43246 G673N 673 G N 0.986 Pathogenic MSH2 P43246 G673P 673 G P 0.966 Pathogenic MSH2 P43246 G673Q 673 G Q 0.994 Pathogenic MSH2 P43246 G673R 673 G R 1 Pathogenic MSH2 P43246 G673S 673 G S 0.832 Pathogenic MSH2 P43246 G673T 673 G T 0.846 Pathogenic MSH2 P43246 G673V 673 G V 0.986 Pathogenic MSH2 P43246 G673W 673 G W 0.98 Pathogenic MSH2 P43246 G673Y 673 G Y 0.96 Pathogenic MSH2 P43246 G674A 674 G A 0.966 Pathogenic 5 MSH2 P43246 G674C 674 G C 0.948 Pathogenic MSH2 P43246 G674D 674 G D 1 Pathogenic 4 MSH2 P43246 G674E 674 G E 0.988 Pathogenic MSH2 P43246 G674F 674 G F 0.984 Pathogenic MSH2 P43246 G674H 674 G H 0.988 Pathogenic MSH2 P43246 G674I 674 G I 0.974 Pathogenic MSH2 P43246 G674K 674 G K 0.988 Pathogenic MSH2 P43246 G674L 674 G L 0.946 Pathogenic MSH2 P43246 G674M 674 G M 0.994 Pathogenic MSH2 P43246 G674N 674 G N 0.986 Pathogenic MSH2 P43246 G674P 674 G P 0.966 Pathogenic MSH2 P43246 G674Q 674 G Q 0.994 Pathogenic MSH2 P43246 G674R 674 G R 1 Pathogenic 4 MSH2 P43246 G674S 674 G S 0.832 Pathogenic MSH2 P43246 G674T 674 G T 0.846 Pathogenic MSH2 P43246 G674V 674 G V 0.986 Pathogenic MSH2 P43246 G674W 674 G W 0.98 Pathogenic MSH2 P43246 G674Y 674 G Y 0.96 Pathogenic MSH2 P43246 K675A 675 K A 0.714 Pathogenic MSH2 P43246 K675C 675 K C 0.626 Pathogenic MSH2 P43246 K675D 675 K D 0.79 Pathogenic MSH2 P43246 K675E 675 K E 0.888 Pathogenic 5 MSH2 P43246 K675F 675 K F 0.962 Pathogenic MSH2 P43246 K675G 675 K G 0.532 Pathogenic MSH2 P43246 K675H 675 K H 0.892 Pathogenic MSH2 P43246 K675I 675 K I 0.992 Pathogenic MSH2 P43246 K675L 675 K L 0.984 Pathogenic MSH2 P43246 K675M 675 K M 0.9 Pathogenic MSH2 P43246 K675N 675 K N 0.802 Pathogenic MSH2 P43246 K675P 675 K P 0.934 Pathogenic MSH2 P43246 K675Q 675 K Q 0.532 Pathogenic MSH2 P43246 K675R 675 K R 0.866 Pathogenic MSH2 P43246 K675S 675 K S 0.65 Pathogenic MSH2 P43246 K675T 675 K T 0.686 Pathogenic MSH2 P43246 K675V 675 K V 0.872 Pathogenic MSH2 P43246 K675W 675 K W 0.988 Pathogenic MSH2 P43246 K675Y 675 K Y 0.978 Pathogenic MSH2 P43246 S676A 676 S A 0.872 Pathogenic MSH2 P43246 S676C 676 S C 0.906 Pathogenic MSH2 P43246 S676D 676 S D 0.708 Pathogenic MSH2 P43246 S676E 676 S E 0.964 Pathogenic MSH2 P43246 S676F 676 S F 0.982 Pathogenic MSH2 P43246 S676G 676 S G 0.7 Pathogenic MSH2 P43246 S676H 676 S H 0.974 Pathogenic MSH2 P43246 S676I 676 S I 0.886 Pathogenic MSH2 P43246 S676K 676 S K 0.954 Pathogenic MSH2 P43246 S676L 676 S L 0.926 Pathogenic MSH2 P43246 S676M 676 S M 0.998 Pathogenic MSH2 P43246 S676N 676 S N 0.892 Pathogenic MSH2 P43246 S676P 676 S P 0.97 Pathogenic MSH2 P43246 S676Q 676 S Q 0.952 Pathogenic MSH2 P43246 S676R 676 S R 0.974 Pathogenic MSH2 P43246 S676T 676 S T 0.762 Pathogenic MSH2 P43246 S676V 676 S V 0.958 Pathogenic MSH2 P43246 S676W 676 S W 0.956 Pathogenic MSH2 P43246 S676Y 676 S Y 0.964 Pathogenic MSH2 P43246 T677A 677 T A 0.72 Pathogenic MSH2 P43246 T677C 677 T C 0.942 Pathogenic MSH2 P43246 T677D 677 T D 0.71 Pathogenic MSH2 P43246 T677E 677 T E 0.952 Pathogenic MSH2 P43246 T677F 677 T F 0.95 Pathogenic MSH2 P43246 T677G 677 T G 0.758 Pathogenic MSH2 P43246 T677H 677 T H 0.926 Pathogenic MSH2 P43246 T677I 677 T I 0.952 Pathogenic MSH2 P43246 T677K 677 T K 0.94 Pathogenic MSH2 P43246 T677L 677 T L 0.952 Pathogenic MSH2 P43246 T677M 677 T M 0.984 Pathogenic MSH2 P43246 T677N 677 T N 0.908 Pathogenic MSH2 P43246 T677P 677 T P 0.968 Pathogenic MSH2 P43246 T677Q 677 T Q 0.896 Pathogenic MSH2 P43246 T677R 677 T R 0.994 Pathogenic MSH2 P43246 T677S 677 T S 0.84 Pathogenic MSH2 P43246 T677V 677 T V 0.762 Pathogenic MSH2 P43246 T677W 677 T W 0.978 Pathogenic MSH2 P43246 T677Y 677 T Y 0.978 Pathogenic MSH2 P43246 Y678A 678 Y A 0.436 Neutral MSH2 P43246 Y678C 678 Y C 0.688 Pathogenic MSH2 P43246 Y678D 678 Y D 0.846 Pathogenic MSH2 P43246 Y678E 678 Y E 0.746 Pathogenic MSH2 P43246 Y678F 678 Y F 0.194 Neutral MSH2 P43246 Y678G 678 Y G 0.48 Neutral MSH2 P43246 Y678H 678 Y H 0.302 Neutral MSH2 P43246 Y678I 678 Y I 0.79 Pathogenic MSH2 P43246 Y678K 678 Y K 0.808 Pathogenic MSH2 P43246 Y678L 678 Y L 0.698 Pathogenic MSH2 P43246 Y678M 678 Y M 0.672 Pathogenic MSH2 P43246 Y678N 678 Y N 0.74 Pathogenic MSH2 P43246 Y678P 678 Y P 0.776 Pathogenic MSH2 P43246 Y678Q 678 Y Q 0.65 Pathogenic MSH2 P43246 Y678R 678 Y R 0.768 Pathogenic MSH2 P43246 Y678S 678 Y S 0.48 Neutral MSH2 P43246 Y678T 678 Y T 0.684 Pathogenic MSH2 P43246 Y678V 678 Y V 0.332 Neutral MSH2 P43246 Y678W 678 Y W 0.518 Pathogenic MSH2 P43246 I679A 679 I A 0.44 Neutral MSH2 P43246 I679C 679 I C 0.734 Pathogenic MSH2 P43246 I679D 679 I D 0.806 Pathogenic MSH2 P43246 I679E 679 I E 0.806 Pathogenic MSH2 P43246 I679F 679 I F 0.844 Pathogenic MSH2 P43246 I679G 679 I G 0.866 Pathogenic MSH2 P43246 I679H 679 I H 0.904 Pathogenic MSH2 P43246 I679K 679 I K 0.84 Pathogenic MSH2 P43246 I679L 679 I L 0.308 Neutral MSH2 P43246 I679M 679 I M 0.52 Pathogenic MSH2 P43246 I679N 679 I N 0.828 Pathogenic MSH2 P43246 I679P 679 I P 0.928 Pathogenic MSH2 P43246 I679Q 679 I Q 0.706 Pathogenic MSH2 P43246 I679R 679 I R 0.898 Pathogenic MSH2 P43246 I679S 679 I S 0.704 Pathogenic MSH2 P43246 I679T 679 I T 0.344 Neutral MSH2 P43246 I679V 679 I V 0.546 Pathogenic MSH2 P43246 I679W 679 I W 0.896 Pathogenic MSH2 P43246 I679Y 679 I Y 0.872 Pathogenic MSH2 P43246 G68A 68 G A 0.314 Neutral MSH2 P43246 G68C 68 G C 0.92 Pathogenic MSH2 P43246 G68D 68 G D 0.702 Pathogenic MSH2 P43246 G68E 68 G E 0.984 Pathogenic MSH2 P43246 G68F 68 G F 0.924 Pathogenic MSH2 P43246 G68H 68 G H 0.722 Pathogenic MSH2 P43246 G68I 68 G I 0.81 Pathogenic MSH2 P43246 G68K 68 G K 0.992 Pathogenic MSH2 P43246 G68L 68 G L 0.722 Pathogenic MSH2 P43246 G68M 68 G M 0.774 Pathogenic MSH2 P43246 G68N 68 G N 0.494 Neutral MSH2 P43246 G68P 68 G P 0.934 Pathogenic MSH2 P43246 G68Q 68 G Q 0.718 Pathogenic MSH2 P43246 G68R 68 G R 0.874 Pathogenic MSH2 P43246 G68S 68 G S 0.338 Neutral MSH2 P43246 G68T 68 G T 0.822 Pathogenic MSH2 P43246 G68V 68 G V 0.99 Pathogenic MSH2 P43246 G68W 68 G W 0.842 Pathogenic MSH2 P43246 G68Y 68 G Y 0.988 Pathogenic MSH2 P43246 R680A 680 R A 0.566 Pathogenic MSH2 P43246 R680C 680 R C 0.95 Pathogenic MSH2 P43246 R680D 680 R D 0.708 Pathogenic MSH2 P43246 R680E 680 R E 0.806 Pathogenic MSH2 P43246 R680F 680 R F 0.862 Pathogenic MSH2 P43246 R680G 680 R G 0.39 Neutral MSH2 P43246 R680H 680 R H 0.428 Neutral MSH2 P43246 R680I 680 R I 0.97 Pathogenic MSH2 P43246 R680K 680 R K 0.624 Pathogenic MSH2 P43246 R680L 680 R L 0.778 Pathogenic MSH2 P43246 R680M 680 R M 0.792 Pathogenic MSH2 P43246 R680N 680 R N 0.67 Pathogenic MSH2 P43246 R680P 680 R P 0.982 Pathogenic MSH2 P43246 R680Q 680 R Q 0.534 Pathogenic MSH2 P43246 R680S 680 R S 0.916 Pathogenic MSH2 P43246 R680T 680 R T 0.948 Pathogenic MSH2 P43246 R680V 680 R V 0.97 Pathogenic MSH2 P43246 R680W 680 R W 0.956 Pathogenic MSH2 P43246 R680Y 680 R Y 0.966 Pathogenic MSH2 P43246 Q681A 681 Q A 0.78 Pathogenic MSH2 P43246 Q681C 681 Q C 0.752 Pathogenic MSH2 P43246 Q681D 681 Q D 0.846 Pathogenic MSH2 P43246 Q681E 681 Q E 0.684 Pathogenic MSH2 P43246 Q681F 681 Q F 0.9 Pathogenic MSH2 P43246 Q681G 681 Q G 0.538 Pathogenic MSH2 P43246 Q681H 681 Q H 0.73 Pathogenic MSH2 P43246 Q681I 681 Q I 0.788 Pathogenic MSH2 P43246 Q681K 681 Q K 0.866 Pathogenic MSH2 P43246 Q681L 681 Q L 0.828 Pathogenic MSH2 P43246 Q681M 681 Q M 0.452 Neutral MSH2 P43246 Q681N 681 Q N 0.888 Pathogenic MSH2 P43246 Q681P 681 Q P 0.894 Pathogenic MSH2 P43246 Q681R 681 Q R 0.922 Pathogenic MSH2 P43246 Q681S 681 Q S 0.16 Neutral MSH2 P43246 Q681T 681 Q T 0.14 Neutral MSH2 P43246 Q681V 681 Q V 0.902 Pathogenic MSH2 P43246 Q681W 681 Q W 0.936 Pathogenic MSH2 P43246 Q681Y 681 Q Y 0.93 Pathogenic MSH2 P43246 T682A 682 T A 0.038 Neutral MSH2 P43246 T682C 682 T C 0.354 Neutral MSH2 P43246 T682D 682 T D 0.61 Pathogenic MSH2 P43246 T682E 682 T E 0.704 Pathogenic MSH2 P43246 T682F 682 T F 0.788 Pathogenic MSH2 P43246 T682G 682 T G 0.338 Neutral MSH2 P43246 T682H 682 T H 0.654 Pathogenic MSH2 P43246 T682I 682 T I 0.126 Neutral MSH2 P43246 T682K 682 T K 0.632 Pathogenic MSH2 P43246 T682L 682 T L 0.444 Neutral MSH2 P43246 T682M 682 T M 0.544 Pathogenic MSH2 P43246 T682N 682 T N 0.426 Neutral MSH2 P43246 T682P 682 T P 0.704 Pathogenic MSH2 P43246 T682Q 682 T Q 0.446 Neutral MSH2 P43246 T682R 682 T R 0.868 Pathogenic MSH2 P43246 T682S 682 T S 0.41 Neutral MSH2 P43246 T682V 682 T V 0.058 Neutral MSH2 P43246 T682W 682 T W 0.936 Pathogenic MSH2 P43246 T682Y 682 T Y 0.932 Pathogenic MSH2 P43246 G683A 683 G A 0.36 Neutral MSH2 P43246 G683C 683 G C 0.94 Pathogenic MSH2 P43246 G683D 683 G D 0.998 Pathogenic MSH2 P43246 G683E 683 G E 0.982 Pathogenic MSH2 P43246 G683F 683 G F 0.976 Pathogenic MSH2 P43246 G683H 683 G H 0.98 Pathogenic MSH2 P43246 G683I 683 G I 0.832 Pathogenic MSH2 P43246 G683K 683 G K 0.98 Pathogenic MSH2 P43246 G683L 683 G L 0.978 Pathogenic MSH2 P43246 G683M 683 G M 0.994 Pathogenic MSH2 P43246 G683N 683 G N 0.694 Pathogenic MSH2 P43246 G683P 683 G P 0.938 Pathogenic MSH2 P43246 G683Q 683 G Q 0.984 Pathogenic MSH2 P43246 G683R 683 G R 1 Pathogenic 5 MSH2 P43246 G683S 683 G S 0.766 Pathogenic MSH2 P43246 G683T 683 G T 0.802 Pathogenic MSH2 P43246 G683V 683 G V 0.892 Pathogenic MSH2 P43246 G683W 683 G W 0.972 Pathogenic MSH2 P43246 G683Y 683 G Y 0.934 Pathogenic MSH2 P43246 V684A 684 V A 0.2 Neutral MSH2 P43246 V684C 684 V C 0.21 Neutral MSH2 P43246 V684D 684 V D 0.494 Neutral MSH2 P43246 V684E 684 V E 0.954 Pathogenic MSH2 P43246 V684F 684 V F 0.932 Pathogenic MSH2 P43246 V684G 684 V G 0.926 Pathogenic MSH2 P43246 V684H 684 V H 0.896 Pathogenic MSH2 P43246 V684I 684 V I 0.268 Neutral MSH2 P43246 V684K 684 V K 0.97 Pathogenic MSH2 P43246 V684L 684 V L 0.324 Neutral MSH2 P43246 V684M 684 V M 0.328 Neutral MSH2 P43246 V684N 684 V N 0.91 Pathogenic MSH2 P43246 V684P 684 V P 0.984 Pathogenic MSH2 P43246 V684Q 684 V Q 0.962 Pathogenic MSH2 P43246 V684R 684 V R 0.946 Pathogenic MSH2 P43246 V684S 684 V S 0.804 Pathogenic MSH2 P43246 V684T 684 V T 0.21 Neutral MSH2 P43246 V684W 684 V W 0.956 Pathogenic MSH2 P43246 V684Y 684 V Y 0.976 Pathogenic MSH2 P43246 I685A 685 I A 0.096 Neutral MSH2 P43246 I685C 685 I C 0.14 Neutral MSH2 P43246 I685D 685 I D 0.76 Pathogenic MSH2 P43246 I685E 685 I E 0.764 Pathogenic MSH2 P43246 I685F 685 I F 0.966 Pathogenic MSH2 P43246 I685G 685 I G 0.808 Pathogenic MSH2 P43246 I685H 685 I H 0.84 Pathogenic MSH2 P43246 I685K 685 I K 0.852 Pathogenic MSH2 P43246 I685L 685 I L 0.184 Neutral MSH2 P43246 I685M 685 I M 0.41 Neutral MSH2 P43246 I685N 685 I N 0.178 Neutral MSH2 P43246 I685P 685 I P 0.944 Pathogenic MSH2 P43246 I685Q 685 I Q 0.796 Pathogenic MSH2 P43246 I685R 685 I R 0.88 Pathogenic MSH2 P43246 I685S 685 I S 0.22 Neutral MSH2 P43246 I685T 685 I T 0.098 Neutral MSH2 P43246 I685V 685 I V 0.108 Neutral MSH2 P43246 I685W 685 I W 0.988 Pathogenic MSH2 P43246 I685Y 685 I Y 0.984 Pathogenic MSH2 P43246 V686A 686 V A 0.112 Neutral MSH2 P43246 V686C 686 V C 0.348 Neutral MSH2 P43246 V686D 686 V D 0.86 Pathogenic MSH2 P43246 V686E 686 V E 0.578 Pathogenic MSH2 P43246 V686F 686 V F 0.876 Pathogenic MSH2 P43246 V686G 686 V G 0.894 Pathogenic MSH2 P43246 V686H 686 V H 0.82 Pathogenic MSH2 P43246 V686I 686 V I 0.184 Neutral MSH2 P43246 V686K 686 V K 0.99 Pathogenic MSH2 P43246 V686L 686 V L 0.834 Pathogenic MSH2 P43246 V686M 686 V M 0.82 Pathogenic MSH2 P43246 V686N 686 V N 0.92 Pathogenic MSH2 P43246 V686P 686 V P 0.984 Pathogenic MSH2 P43246 V686Q 686 V Q 0.984 Pathogenic MSH2 P43246 V686R 686 V R 0.952 Pathogenic MSH2 P43246 V686S 686 V S 0.134 Neutral MSH2 P43246 V686T 686 V T 0.104 Neutral MSH2 P43246 V686W 686 V W 0.904 Pathogenic MSH2 P43246 V686Y 686 V Y 0.928 Pathogenic MSH2 P43246 L687A 687 L A 0.716 Pathogenic MSH2 P43246 L687C 687 L C 0.83 Pathogenic MSH2 P43246 L687D 687 L D 0.912 Pathogenic MSH2 P43246 L687E 687 L E 0.894 Pathogenic MSH2 P43246 L687F 687 L F 0.884 Pathogenic MSH2 P43246 L687G 687 L G 0.862 Pathogenic MSH2 P43246 L687H 687 L H 0.908 Pathogenic MSH2 P43246 L687I 687 L I 0.94 Pathogenic MSH2 P43246 L687K 687 L K 0.732 Pathogenic MSH2 P43246 L687M 687 L M 0.498 Neutral MSH2 P43246 L687N 687 L N 0.822 Pathogenic MSH2 P43246 L687P 687 L P 0.986 Pathogenic MSH2 P43246 L687Q 687 L Q 0.778 Pathogenic MSH2 P43246 L687R 687 L R 0.982 Pathogenic MSH2 P43246 L687S 687 L S 0.712 Pathogenic MSH2 P43246 L687T 687 L T 0.636 Pathogenic MSH2 P43246 L687V 687 L V 0.302 Neutral MSH2 P43246 L687W 687 L W 0.886 Pathogenic MSH2 P43246 L687Y 687 L Y 0.896 Pathogenic MSH2 P43246 M688A 688 M A 0.696 Pathogenic MSH2 P43246 M688C 688 M C 0.642 Pathogenic MSH2 P43246 M688D 688 M D 0.884 Pathogenic MSH2 P43246 M688E 688 M E 0.832 Pathogenic MSH2 P43246 M688F 688 M F 0.814 Pathogenic MSH2 P43246 M688G 688 M G 0.528 Pathogenic MSH2 P43246 M688H 688 M H 0.956 Pathogenic MSH2 P43246 M688I 688 M I 0.638 Pathogenic MSH2 P43246 M688K 688 M K 0.966 Pathogenic MSH2 P43246 M688L 688 M L 0.398 Neutral MSH2 P43246 M688N 688 M N 0.912 Pathogenic MSH2 P43246 M688P 688 M P 0.936 Pathogenic MSH2 P43246 M688Q 688 M Q 0.804 Pathogenic MSH2 P43246 M688R 688 M R 0.968 Pathogenic 5 MSH2 P43246 M688S 688 M S 0.912 Pathogenic MSH2 P43246 M688T 688 M T 0.496 Neutral MSH2 P43246 M688V 688 M V 0.636 Pathogenic MSH2 P43246 M688W 688 M W 0.968 Pathogenic MSH2 P43246 M688Y 688 M Y 0.964 Pathogenic MSH2 P43246 A689C 689 A C 0.87 Pathogenic MSH2 P43246 A689D 689 A D 0.93 Pathogenic MSH2 P43246 A689E 689 A E 0.884 Pathogenic MSH2 P43246 A689F 689 A F 0.97 Pathogenic MSH2 P43246 A689G 689 A G 0.77 Pathogenic MSH2 P43246 A689H 689 A H 0.872 Pathogenic MSH2 P43246 A689I 689 A I 0.962 Pathogenic MSH2 P43246 A689K 689 A K 0.94 Pathogenic MSH2 P43246 A689L 689 A L 0.984 Pathogenic MSH2 P43246 A689M 689 A M 0.86 Pathogenic MSH2 P43246 A689N 689 A N 0.864 Pathogenic MSH2 P43246 A689P 689 A P 0.966 Pathogenic MSH2 P43246 A689Q 689 A Q 0.824 Pathogenic MSH2 P43246 A689R 689 A R 0.856 Pathogenic MSH2 P43246 A689S 689 A S 0.424 Neutral MSH2 P43246 A689T 689 A T 0.468 Neutral MSH2 P43246 A689V 689 A V 0.914 Pathogenic MSH2 P43246 A689W 689 A W 0.98 Pathogenic MSH2 P43246 A689Y 689 A Y 0.966 Pathogenic MSH2 P43246 P69A 69 P A 0.04 Neutral MSH2 P43246 P69C 69 P C 0.242 Neutral MSH2 P43246 P69D 69 P D 0.134 Neutral MSH2 P43246 P69E 69 P E 0.164 Neutral MSH2 P43246 P69F 69 P F 0.522 Pathogenic MSH2 P43246 P69G 69 P G 0.016 Neutral MSH2 P43246 P69H 69 P H 0.484 Neutral MSH2 P43246 P69I 69 P I 0.218 Neutral MSH2 P43246 P69K 69 P K 0.076 Neutral MSH2 P43246 P69L 69 P L 0.05 Neutral MSH2 P43246 P69M 69 P M 0.386 Neutral MSH2 P43246 P69N 69 P N 0.03 Neutral MSH2 P43246 P69Q 69 P Q 0.372 Neutral MSH2 P43246 P69R 69 P R 0.318 Neutral MSH2 P43246 P69S 69 P S 0.008 Neutral MSH2 P43246 P69T 69 P T 0.258 Neutral MSH2 P43246 P69V 69 P V 0.084 Neutral MSH2 P43246 P69W 69 P W 0.616 Pathogenic MSH2 P43246 P69Y 69 P Y 0.546 Pathogenic MSH2 P43246 Q690A 690 Q A 0.786 Pathogenic MSH2 P43246 Q690C 690 Q C 0.544 Pathogenic MSH2 P43246 Q690D 690 Q D 0.588 Pathogenic MSH2 P43246 Q690E 690 Q E 0.734 Pathogenic MSH2 P43246 Q690F 690 Q F 0.922 Pathogenic MSH2 P43246 Q690G 690 Q G 0.532 Pathogenic MSH2 P43246 Q690H 690 Q H 0.456 Neutral MSH2 P43246 Q690I 690 Q I 0.952 Pathogenic MSH2 P43246 Q690K 690 Q K 0.91 Pathogenic MSH2 P43246 Q690L 690 Q L 0.862 Pathogenic MSH2 P43246 Q690M 690 Q M 0.9 Pathogenic MSH2 P43246 Q690N 690 Q N 0.9 Pathogenic MSH2 P43246 Q690P 690 Q P 0.916 Pathogenic MSH2 P43246 Q690R 690 Q R 0.926 Pathogenic MSH2 P43246 Q690S 690 Q S 0.672 Pathogenic MSH2 P43246 Q690T 690 Q T 0.484 Neutral MSH2 P43246 Q690V 690 Q V 0.926 Pathogenic MSH2 P43246 Q690W 690 Q W 0.956 Pathogenic MSH2 P43246 Q690Y 690 Q Y 0.942 Pathogenic MSH2 P43246 I691A 691 I A 0.11 Neutral MSH2 P43246 I691C 691 I C 0.34 Neutral MSH2 P43246 I691D 691 I D 0.748 Pathogenic MSH2 P43246 I691E 691 I E 0.758 Pathogenic MSH2 P43246 I691F 691 I F 0.96 Pathogenic MSH2 P43246 I691G 691 I G 0.798 Pathogenic MSH2 P43246 I691H 691 I H 0.848 Pathogenic MSH2 P43246 I691K 691 I K 0.508 Pathogenic MSH2 P43246 I691L 691 I L 0.118 Neutral MSH2 P43246 I691M 691 I M 0.238 Neutral MSH2 P43246 I691N 691 I N 0.774 Pathogenic MSH2 P43246 I691P 691 I P 0.934 Pathogenic MSH2 P43246 I691Q 691 I Q 0.788 Pathogenic MSH2 P43246 I691R 691 I R 0.874 Pathogenic MSH2 P43246 I691S 691 I S 0.616 Pathogenic MSH2 P43246 I691T 691 I T 0.082 Neutral MSH2 P43246 I691V 691 I V 0.122 Neutral MSH2 P43246 I691W 691 I W 0.986 Pathogenic MSH2 P43246 I691Y 691 I Y 0.976 Pathogenic MSH2 P43246 G692A 692 G A 0.966 Pathogenic MSH2 P43246 G692C 692 G C 0.948 Pathogenic MSH2 P43246 G692D 692 G D 1 Pathogenic MSH2 P43246 G692E 692 G E 0.988 Pathogenic MSH2 P43246 G692F 692 G F 0.984 Pathogenic MSH2 P43246 G692H 692 G H 0.988 Pathogenic MSH2 P43246 G692I 692 G I 0.974 Pathogenic MSH2 P43246 G692K 692 G K 0.988 Pathogenic MSH2 P43246 G692L 692 G L 0.984 Pathogenic MSH2 P43246 G692M 692 G M 0.994 Pathogenic MSH2 P43246 G692N 692 G N 0.986 Pathogenic MSH2 P43246 G692P 692 G P 0.966 Pathogenic MSH2 P43246 G692Q 692 G Q 0.994 Pathogenic MSH2 P43246 G692R 692 G R 1 Pathogenic 4 MSH2 P43246 G692S 692 G S 0.674 Pathogenic MSH2 P43246 G692T 692 G T 0.846 Pathogenic MSH2 P43246 G692V 692 G V 0.986 Pathogenic MSH2 P43246 G692W 692 G W 0.98 Pathogenic MSH2 P43246 G692Y 692 G Y 0.96 Pathogenic MSH2 P43246 C693A 693 C A 0.184 Neutral MSH2 P43246 C693D 693 C D 0.946 Pathogenic MSH2 P43246 C693E 693 C E 0.844 Pathogenic MSH2 P43246 C693F 693 C F 0.966 Pathogenic MSH2 P43246 C693G 693 C G 0.942 Pathogenic MSH2 P43246 C693H 693 C H 0.804 Pathogenic MSH2 P43246 C693I 693 C I 0.952 Pathogenic MSH2 P43246 C693K 693 C K 0.874 Pathogenic MSH2 P43246 C693L 693 C L 0.956 Pathogenic MSH2 P43246 C693M 693 C M 0.712 Pathogenic MSH2 P43246 C693N 693 C N 0.812 Pathogenic MSH2 P43246 C693P 693 C P 0.97 Pathogenic MSH2 P43246 C693Q 693 C Q 0.608 Pathogenic MSH2 P43246 C693R 693 C R 1 Pathogenic MSH2 P43246 C693S 693 C S 0.078 Neutral MSH2 P43246 C693T 693 C T 0.674 Pathogenic MSH2 P43246 C693V 693 C V 0.954 Pathogenic MSH2 P43246 C693W 693 C W 0.976 Pathogenic MSH2 P43246 C693Y 693 C Y 0.962 Pathogenic MSH2 P43246 F694A 694 F A 0.498 Neutral MSH2 P43246 F694C 694 F C 0.728 Pathogenic MSH2 P43246 F694D 694 F D 0.816 Pathogenic MSH2 P43246 F694E 694 F E 0.87 Pathogenic MSH2 P43246 F694G 694 F G 0.506 Pathogenic MSH2 P43246 F694H 694 F H 0.772 Pathogenic MSH2 P43246 F694I 694 F I 0.692 Pathogenic MSH2 P43246 F694K 694 F K 0.85 Pathogenic MSH2 P43246 F694L 694 F L 0.422 Neutral MSH2 P43246 F694M 694 F M 0.788 Pathogenic MSH2 P43246 F694N 694 F N 0.766 Pathogenic MSH2 P43246 F694P 694 F P 0.676 Pathogenic MSH2 P43246 F694Q 694 F Q 0.788 Pathogenic MSH2 P43246 F694R 694 F R 0.918 Pathogenic MSH2 P43246 F694S 694 F S 0.868 Pathogenic 5 MSH2 P43246 F694T 694 F T 0.59 Pathogenic MSH2 P43246 F694V 694 F V 0.748 Pathogenic MSH2 P43246 F694W 694 F W 0.83 Pathogenic MSH2 P43246 F694Y 694 F Y 0.444 Neutral MSH2 P43246 V695A 695 V A 0.54 Pathogenic MSH2 P43246 V695C 695 V C 0.818 Pathogenic MSH2 P43246 V695D 695 V D 0.868 Pathogenic MSH2 P43246 V695E 695 V E 0.958 Pathogenic MSH2 P43246 V695F 695 V F 0.93 Pathogenic MSH2 P43246 V695G 695 V G 0.92 Pathogenic MSH2 P43246 V695H 695 V H 0.912 Pathogenic MSH2 P43246 V695I 695 V I 0.458 Neutral MSH2 P43246 V695K 695 V K 0.982 Pathogenic MSH2 P43246 V695L 695 V L 0.582 Pathogenic MSH2 P43246 V695M 695 V M 0.92 Pathogenic MSH2 P43246 V695N 695 V N 0.924 Pathogenic MSH2 P43246 V695P 695 V P 0.99 Pathogenic MSH2 P43246 V695Q 695 V Q 0.964 Pathogenic MSH2 P43246 V695R 695 V R 0.95 Pathogenic MSH2 P43246 V695S 695 V S 0.82 Pathogenic MSH2 P43246 V695T 695 V T 0.886 Pathogenic MSH2 P43246 V695W 695 V W 0.954 Pathogenic MSH2 P43246 V695Y 695 V Y 0.974 Pathogenic MSH2 P43246 P696A 696 P A 0.472 Neutral MSH2 P43246 P696C 696 P C 0.918 Pathogenic MSH2 P43246 P696D 696 P D 0.87 Pathogenic MSH2 P43246 P696E 696 P E 0.956 Pathogenic MSH2 P43246 P696F 696 P F 1 Pathogenic MSH2 P43246 P696G 696 P G 0.696 Pathogenic MSH2 P43246 P696H 696 P H 0.976 Pathogenic MSH2 P43246 P696I 696 P I 0.878 Pathogenic MSH2 P43246 P696K 696 P K 0.946 Pathogenic MSH2 P43246 P696L 696 P L 0.998 Pathogenic 5 MSH2 P43246 P696M 696 P M 0.956 Pathogenic MSH2 P43246 P696N 696 P N 0.792 Pathogenic MSH2 P43246 P696Q 696 P Q 0.878 Pathogenic MSH2 P43246 P696R 696 P R 0.984 Pathogenic MSH2 P43246 P696S 696 P S 0.368 Neutral MSH2 P43246 P696T 696 P T 0.756 Pathogenic MSH2 P43246 P696V 696 P V 0.848 Pathogenic MSH2 P43246 P696W 696 P W 0.936 Pathogenic MSH2 P43246 P696Y 696 P Y 0.932 Pathogenic MSH2 P43246 C697A 697 C A 0.36 Neutral MSH2 P43246 C697D 697 C D 0.96 Pathogenic MSH2 P43246 C697E 697 C E 0.836 Pathogenic MSH2 P43246 C697F 697 C F 0.966 Pathogenic 5 MSH2 P43246 C697G 697 C G 0.94 Pathogenic MSH2 P43246 C697H 697 C H 0.794 Pathogenic MSH2 P43246 C697I 697 C I 0.842 Pathogenic MSH2 P43246 C697K 697 C K 0.874 Pathogenic MSH2 P43246 C697L 697 C L 0.92 Pathogenic MSH2 P43246 C697M 697 C M 0.688 Pathogenic MSH2 P43246 C697N 697 C N 0.83 Pathogenic MSH2 P43246 C697P 697 C P 0.97 Pathogenic MSH2 P43246 C697Q 697 C Q 0.576 Pathogenic MSH2 P43246 C697R 697 C R 1 Pathogenic 5 MSH2 P43246 C697S 697 C S 0.452 Neutral MSH2 P43246 C697T 697 C T 0.608 Pathogenic MSH2 P43246 C697V 697 C V 0.952 Pathogenic MSH2 P43246 C697W 697 C W 0.976 Pathogenic MSH2 P43246 C697Y 697 C Y 0.962 Pathogenic MSH2 P43246 E698A 698 E A 0.208 Neutral MSH2 P43246 E698C 698 E C 0.494 Neutral MSH2 P43246 E698D 698 E D 0.018 Neutral MSH2 P43246 E698F 698 E F 0.88 Pathogenic MSH2 P43246 E698G 698 E G 0.038 Neutral MSH2 P43246 E698H 698 E H 0.612 Pathogenic MSH2 P43246 E698I 698 E I 0.938 Pathogenic MSH2 P43246 E698K 698 E K 0.74 Pathogenic MSH2 P43246 E698L 698 E L 0.43 Neutral MSH2 P43246 E698M 698 E M 0.714 Pathogenic MSH2 P43246 E698N 698 E N 0.028 Neutral MSH2 P43246 E698P 698 E P 0.888 Pathogenic MSH2 P43246 E698Q 698 E Q 0.038 Neutral MSH2 P43246 E698R 698 E R 0.598 Pathogenic MSH2 P43246 E698S 698 E S 0.046 Neutral MSH2 P43246 E698T 698 E T 0.044 Neutral MSH2 P43246 E698V 698 E V 0.85 Pathogenic MSH2 P43246 E698W 698 E W 0.97 Pathogenic MSH2 P43246 E698Y 698 E Y 0.92 Pathogenic MSH2 P43246 S699A 699 S A 0.058 Neutral MSH2 P43246 S699C 699 S C 0.504 Pathogenic MSH2 P43246 S699D 699 S D 0.372 Neutral MSH2 P43246 S699E 699 S E 0.472 Neutral MSH2 P43246 S699F 699 S F 0.612 Pathogenic MSH2 P43246 S699G 699 S G 0.206 Neutral MSH2 P43246 S699H 699 S H 0.674 Pathogenic MSH2 P43246 S699I 699 S I 0.632 Pathogenic MSH2 P43246 S699K 699 S K 0.452 Neutral MSH2 P43246 S699L 699 S L 0.18 Neutral MSH2 P43246 S699M 699 S M 0.72 Pathogenic MSH2 P43246 S699N 699 S N 0.066 Neutral MSH2 P43246 S699P 699 S P 0.662 Pathogenic MSH2 P43246 S699Q 699 S Q 0.48 Neutral MSH2 P43246 S699R 699 S R 0.49 Neutral MSH2 P43246 S699T 699 S T 0.078 Neutral MSH2 P43246 S699V 699 S V 0.824 Pathogenic MSH2 P43246 S699W 699 S W 0.954 Pathogenic MSH2 P43246 S699Y 699 S Y 0.778 Pathogenic MSH2 P43246 E7A 7 E A 0.212 Neutral MSH2 P43246 E7C 7 E C 0.07 Neutral MSH2 P43246 E7D 7 E D 0 Neutral MSH2 P43246 E7F 7 E F 0.306 Neutral MSH2 P43246 E7G 7 E G 0.024 Neutral MSH2 P43246 E7H 7 E H 0.096 Neutral MSH2 P43246 E7I 7 E I 0.362 Neutral MSH2 P43246 E7K 7 E K 0.152 Neutral MSH2 P43246 E7L 7 E L 0.048 Neutral MSH2 P43246 E7M 7 E M 0.176 Neutral MSH2 P43246 E7N 7 E N 0.058 Neutral MSH2 P43246 E7P 7 E P 0.056 Neutral MSH2 P43246 E7Q 7 E Q 0 Neutral MSH2 P43246 E7R 7 E R 0.054 Neutral MSH2 P43246 E7S 7 E S 0.158 Neutral MSH2 P43246 E7T 7 E T 0.144 Neutral MSH2 P43246 E7V 7 E V 0.256 Neutral MSH2 P43246 E7W 7 E W 0.524 Pathogenic MSH2 P43246 E7Y 7 E Y 0.424 Neutral MSH2 P43246 A70C 70 A C 0.326 Neutral MSH2 P43246 A70D 70 A D 0.438 Neutral MSH2 P43246 A70E 70 A E 0.362 Neutral MSH2 P43246 A70F 70 A F 0.722 Pathogenic MSH2 P43246 A70G 70 A G 0.004 Neutral MSH2 P43246 A70H 70 A H 0.466 Neutral MSH2 P43246 A70I 70 A I 0.708 Pathogenic MSH2 P43246 A70K 70 A K 0.364 Neutral MSH2 P43246 A70L 70 A L 0.656 Pathogenic MSH2 P43246 A70M 70 A M 0.484 Neutral MSH2 P43246 A70N 70 A N 0.39 Neutral MSH2 P43246 A70P 70 A P 0.12 Neutral MSH2 P43246 A70Q 70 A Q 0.488 Neutral MSH2 P43246 A70R 70 A R 0.458 Neutral MSH2 P43246 A70S 70 A S 0.014 Neutral MSH2 P43246 A70T 70 A T 0.04 Neutral MSH2 P43246 A70V 70 A V 0.422 Neutral MSH2 P43246 A70W 70 A W 0.754 Pathogenic MSH2 P43246 A70Y 70 A Y 0.742 Pathogenic MSH2 P43246 A700C 700 A C 0.74 Pathogenic MSH2 P43246 A700D 700 A D 0.928 Pathogenic MSH2 P43246 A700E 700 A E 0.882 Pathogenic MSH2 P43246 A700F 700 A F 0.968 Pathogenic MSH2 P43246 A700G 700 A G 0.764 Pathogenic MSH2 P43246 A700H 700 A H 0.87 Pathogenic MSH2 P43246 A700I 700 A I 0.96 Pathogenic MSH2 P43246 A700K 700 A K 0.938 Pathogenic MSH2 P43246 A700L 700 A L 0.982 Pathogenic MSH2 P43246 A700M 700 A M 0.858 Pathogenic MSH2 P43246 A700N 700 A N 0.862 Pathogenic MSH2 P43246 A700P 700 A P 0.92 Pathogenic MSH2 P43246 A700Q 700 A Q 0.822 Pathogenic MSH2 P43246 A700R 700 A R 0.96 Pathogenic MSH2 P43246 A700S 700 A S 0.448 Neutral MSH2 P43246 A700T 700 A T 0.742 Pathogenic MSH2 P43246 A700V 700 A V 0.65 Pathogenic MSH2 P43246 A700W 700 A W 0.978 Pathogenic MSH2 P43246 A700Y 700 A Y 0.964 Pathogenic MSH2 P43246 E701A 701 E A 0.65 Pathogenic MSH2 P43246 E701C 701 E C 0.584 Pathogenic MSH2 P43246 E701D 701 E D 0.124 Neutral MSH2 P43246 E701F 701 E F 0.872 Pathogenic MSH2 P43246 E701G 701 E G 0.322 Neutral MSH2 P43246 E701H 701 E H 0.61 Pathogenic MSH2 P43246 E701I 701 E I 0.596 Pathogenic MSH2 P43246 E701K 701 E K 0.318 Neutral MSH2 P43246 E701L 701 E L 0.9 Pathogenic MSH2 P43246 E701M 701 E M 0.732 Pathogenic MSH2 P43246 E701N 701 E N 0.102 Neutral MSH2 P43246 E701P 701 E P 0.88 Pathogenic MSH2 P43246 E701Q 701 E Q 0.09 Neutral MSH2 P43246 E701R 701 E R 0.264 Neutral MSH2 P43246 E701S 701 E S 0.158 Neutral MSH2 P43246 E701T 701 E T 0.18 Neutral MSH2 P43246 E701V 701 E V 0.366 Neutral MSH2 P43246 E701W 701 E W 0.938 Pathogenic MSH2 P43246 E701Y 701 E Y 0.906 Pathogenic MSH2 P43246 V702A 702 V A 0.334 Neutral MSH2 P43246 V702C 702 V C 0.714 Pathogenic MSH2 P43246 V702D 702 V D 0.866 Pathogenic MSH2 P43246 V702E 702 V E 0.984 Pathogenic MSH2 P43246 V702F 702 V F 0.876 Pathogenic MSH2 P43246 V702G 702 V G 0.902 Pathogenic MSH2 P43246 V702H 702 V H 0.82 Pathogenic MSH2 P43246 V702I 702 V I 0.138 Neutral MSH2 P43246 V702K 702 V K 0.99 Pathogenic MSH2 P43246 V702L 702 V L 0.162 Neutral MSH2 P43246 V702M 702 V M 0.23 Neutral MSH2 P43246 V702N 702 V N 0.926 Pathogenic MSH2 P43246 V702P 702 V P 0.984 Pathogenic MSH2 P43246 V702Q 702 V Q 0.99 Pathogenic MSH2 P43246 V702R 702 V R 0.958 Pathogenic MSH2 P43246 V702S 702 V S 0.726 Pathogenic MSH2 P43246 V702T 702 V T 0.748 Pathogenic MSH2 P43246 V702W 702 V W 0.904 Pathogenic MSH2 P43246 V702Y 702 V Y 0.928 Pathogenic MSH2 P43246 S703A 703 S A 0.166 Neutral MSH2 P43246 S703C 703 S C 0.258 Neutral MSH2 P43246 S703D 703 S D 0.506 Pathogenic MSH2 P43246 S703E 703 S E 0.906 Pathogenic MSH2 P43246 S703F 703 S F 0.978 Pathogenic MSH2 P43246 S703G 703 S G 0.14 Neutral MSH2 P43246 S703H 703 S H 0.92 Pathogenic MSH2 P43246 S703I 703 S I 0.85 Pathogenic MSH2 P43246 S703K 703 S K 0.894 Pathogenic MSH2 P43246 S703L 703 S L 0.874 Pathogenic MSH2 P43246 S703M 703 S M 0.994 Pathogenic MSH2 P43246 S703N 703 S N 0.742 Pathogenic MSH2 P43246 S703P 703 S P 0.35 Neutral MSH2 P43246 S703Q 703 S Q 0.86 Pathogenic MSH2 P43246 S703R 703 S R 0.928 Pathogenic MSH2 P43246 S703T 703 S T 0.306 Neutral MSH2 P43246 S703V 703 S V 0.926 Pathogenic MSH2 P43246 S703W 703 S W 0.968 Pathogenic MSH2 P43246 S703Y 703 S Y 0.966 Pathogenic MSH2 P43246 I704A 704 I A 0.526 Pathogenic MSH2 P43246 I704C 704 I C 0.64 Pathogenic MSH2 P43246 I704D 704 I D 0.736 Pathogenic MSH2 P43246 I704E 704 I E 0.748 Pathogenic MSH2 P43246 I704F 704 I F 0.96 Pathogenic MSH2 P43246 I704G 704 I G 0.798 Pathogenic MSH2 P43246 I704H 704 I H 0.89 Pathogenic MSH2 P43246 I704K 704 I K 0.844 Pathogenic MSH2 P43246 I704L 704 I L 0.088 Neutral MSH2 P43246 I704M 704 I M 0.188 Neutral MSH2 P43246 I704N 704 I N 0.762 Pathogenic MSH2 P43246 I704P 704 I P 0.922 Pathogenic MSH2 P43246 I704Q 704 I Q 0.778 Pathogenic MSH2 P43246 I704R 704 I R 0.666 Pathogenic MSH2 P43246 I704S 704 I S 0.616 Pathogenic MSH2 P43246 I704T 704 I T 0.318 Neutral MSH2 P43246 I704V 704 I V 0.136 Neutral MSH2 P43246 I704W 704 I W 0.986 Pathogenic MSH2 P43246 I704Y 704 I Y 0.976 Pathogenic MSH2 P43246 V705A 705 V A 0.31 Neutral MSH2 P43246 V705C 705 V C 0.156 Neutral MSH2 P43246 V705D 705 V D 0.85 Pathogenic MSH2 P43246 V705E 705 V E 0.952 Pathogenic MSH2 P43246 V705F 705 V F 0.498 Neutral MSH2 P43246 V705G 705 V G 0.912 Pathogenic MSH2 P43246 V705H 705 V H 0.762 Pathogenic MSH2 P43246 V705I 705 V I 0.186 Neutral MSH2 P43246 V705K 705 V K 0.676 Pathogenic MSH2 P43246 V705L 705 V L 0.206 Neutral MSH2 P43246 V705M 705 V M 0.274 Neutral MSH2 P43246 V705N 705 V N 0.92 Pathogenic MSH2 P43246 V705P 705 V P 0.942 Pathogenic MSH2 P43246 V705Q 705 V Q 0.97 Pathogenic MSH2 P43246 V705R 705 V R 0.522 Pathogenic MSH2 P43246 V705S 705 V S 0.374 Neutral MSH2 P43246 V705T 705 V T 0.134 Neutral MSH2 P43246 V705W 705 V W 0.876 Pathogenic MSH2 P43246 V705Y 705 V Y 0.546 Pathogenic MSH2 P43246 D706A 706 D A 0.568 Pathogenic MSH2 P43246 D706C 706 D C 0.868 Pathogenic MSH2 P43246 D706E 706 D E 0.806 Pathogenic MSH2 P43246 D706F 706 D F 0.974 Pathogenic MSH2 P43246 D706G 706 D G 0.92 Pathogenic MSH2 P43246 D706H 706 D H 0.674 Pathogenic MSH2 P43246 D706I 706 D I 0.962 Pathogenic MSH2 P43246 D706K 706 D K 0.682 Pathogenic MSH2 P43246 D706L 706 D L 0.964 Pathogenic MSH2 P43246 D706M 706 D M 0.948 Pathogenic MSH2 P43246 D706N 706 D N 0.846 Pathogenic MSH2 P43246 D706P 706 D P 0.892 Pathogenic MSH2 P43246 D706Q 706 D Q 0.612 Pathogenic MSH2 P43246 D706R 706 D R 0.956 Pathogenic MSH2 P43246 D706S 706 D S 0.38 Neutral MSH2 P43246 D706T 706 D T 0.788 Pathogenic MSH2 P43246 D706V 706 D V 0.982 Pathogenic MSH2 P43246 D706W 706 D W 0.978 Pathogenic MSH2 P43246 D706Y 706 D Y 0.972 Pathogenic MSH2 P43246 C707A 707 C A 0.108 Neutral MSH2 P43246 C707D 707 C D 0.882 Pathogenic MSH2 P43246 C707E 707 C E 0.888 Pathogenic MSH2 P43246 C707F 707 C F 0.994 Pathogenic MSH2 P43246 C707G 707 C G 0.19 Neutral MSH2 P43246 C707H 707 C H 0.892 Pathogenic MSH2 P43246 C707I 707 C I 0.95 Pathogenic MSH2 P43246 C707K 707 C K 0.876 Pathogenic MSH2 P43246 C707L 707 C L 0.978 Pathogenic MSH2 P43246 C707M 707 C M 0.798 Pathogenic MSH2 P43246 C707N 707 C N 0.698 Pathogenic MSH2 P43246 C707P 707 C P 0.97 Pathogenic MSH2 P43246 C707Q 707 C Q 0.714 Pathogenic MSH2 P43246 C707R 707 C R 0.668 Pathogenic MSH2 P43246 C707S 707 C S 0.138 Neutral MSH2 P43246 C707T 707 C T 0.358 Neutral MSH2 P43246 C707V 707 C V 0.95 Pathogenic MSH2 P43246 C707W 707 C W 0.996 Pathogenic MSH2 P43246 C707Y 707 C Y 0.99 Pathogenic MSH2 P43246 I708A 708 I A 0.646 Pathogenic MSH2 P43246 I708C 708 I C 0.738 Pathogenic MSH2 P43246 I708D 708 I D 0.812 Pathogenic MSH2 P43246 I708E 708 I E 0.812 Pathogenic MSH2 P43246 I708F 708 I F 0.844 Pathogenic MSH2 P43246 I708G 708 I G 0.872 Pathogenic MSH2 P43246 I708H 708 I H 0.908 Pathogenic MSH2 P43246 I708K 708 I K 0.846 Pathogenic MSH2 P43246 I708L 708 I L 0.38 Neutral MSH2 P43246 I708M 708 I M 0.66 Pathogenic MSH2 P43246 I708N 708 I N 0.834 Pathogenic MSH2 P43246 I708P 708 I P 0.93 Pathogenic MSH2 P43246 I708Q 708 I Q 0.84 Pathogenic MSH2 P43246 I708R 708 I R 0.902 Pathogenic MSH2 P43246 I708S 708 I S 0.708 Pathogenic MSH2 P43246 I708T 708 I T 0.346 Neutral MSH2 P43246 I708V 708 I V 0.27 Neutral MSH2 P43246 I708W 708 I W 0.896 Pathogenic MSH2 P43246 I708Y 708 I Y 0.872 Pathogenic MSH2 P43246 L709A 709 L A 0.318 Neutral MSH2 P43246 L709C 709 L C 0.392 Neutral MSH2 P43246 L709D 709 L D 0.884 Pathogenic MSH2 P43246 L709E 709 L E 0.866 Pathogenic MSH2 P43246 L709F 709 L F 0.452 Neutral MSH2 P43246 L709G 709 L G 0.858 Pathogenic MSH2 P43246 L709H 709 L H 0.46 Neutral MSH2 P43246 L709I 709 L I 0.916 Pathogenic MSH2 P43246 L709K 709 L K 0.69 Pathogenic MSH2 P43246 L709M 709 L M 0.18 Neutral MSH2 P43246 L709N 709 L N 0.796 Pathogenic MSH2 P43246 L709P 709 L P 0.966 Pathogenic MSH2 P43246 L709Q 709 L Q 0.428 Neutral MSH2 P43246 L709R 709 L R 0.974 Pathogenic MSH2 P43246 L709S 709 L S 0.68 Pathogenic MSH2 P43246 L709T 709 L T 0.598 Pathogenic MSH2 P43246 L709V 709 L V 0.356 Neutral MSH2 P43246 L709W 709 L W 0.846 Pathogenic MSH2 P43246 L709Y 709 L Y 0.868 Pathogenic MSH2 P43246 G71A 71 G A 0.006 Neutral MSH2 P43246 G71C 71 G C 0.364 Neutral MSH2 P43246 G71D 71 G D 0.248 Neutral MSH2 P43246 G71E 71 G E 0.302 Neutral MSH2 P43246 G71F 71 G F 0.762 Pathogenic MSH2 P43246 G71H 71 G H 0.4 Neutral MSH2 P43246 G71I 71 G I 0.676 Pathogenic MSH2 P43246 G71K 71 G K 0.394 Neutral MSH2 P43246 G71L 71 G L 0.524 Pathogenic MSH2 P43246 G71M 71 G M 0.694 Pathogenic MSH2 P43246 G71N 71 G N 0.274 Neutral MSH2 P43246 G71P 71 G P 0.444 Neutral MSH2 P43246 G71Q 71 G Q 0.454 Neutral MSH2 P43246 G71R 71 G R 0.404 Neutral MSH2 P43246 G71S 71 G S 0.022 Neutral MSH2 P43246 G71T 71 G T 0.358 Neutral MSH2 P43246 G71V 71 G V 0.428 Neutral MSH2 P43246 G71W 71 G W 0.76 Pathogenic MSH2 P43246 G71Y 71 G Y 0.744 Pathogenic MSH2 P43246 A710C 710 A C 0.34 Neutral MSH2 P43246 A710D 710 A D 0.922 Pathogenic MSH2 P43246 A710E 710 A E 0.902 Pathogenic MSH2 P43246 A710F 710 A F 0.966 Pathogenic MSH2 P43246 A710G 710 A G 0.096 Neutral MSH2 P43246 A710H 710 A H 0.886 Pathogenic MSH2 P43246 A710I 710 A I 0.956 Pathogenic MSH2 P43246 A710K 710 A K 0.94 Pathogenic MSH2 P43246 A710L 710 A L 0.98 Pathogenic MSH2 P43246 A710M 710 A M 0.864 Pathogenic MSH2 P43246 A710N 710 A N 0.846 Pathogenic MSH2 P43246 A710P 710 A P 0.968 Pathogenic MSH2 P43246 A710Q 710 A Q 0.834 Pathogenic MSH2 P43246 A710R 710 A R 0.96 Pathogenic MSH2 P43246 A710S 710 A S 0.12 Neutral MSH2 P43246 A710T 710 A T 0.17 Neutral MSH2 P43246 A710V 710 A V 0.782 Pathogenic MSH2 P43246 A710W 710 A W 0.976 Pathogenic MSH2 P43246 A710Y 710 A Y 0.96 Pathogenic MSH2 P43246 R711A 711 R A 0.574 Pathogenic MSH2 P43246 R711C 711 R C 0.96 Pathogenic MSH2 P43246 R711D 711 R D 0.714 Pathogenic MSH2 P43246 R711E 711 R E 0.814 Pathogenic MSH2 P43246 R711F 711 R F 0.976 Pathogenic MSH2 P43246 R711G 711 R G 0.404 Neutral MSH2 P43246 R711H 711 R H 0.432 Neutral MSH2 P43246 R711I 711 R I 0.98 Pathogenic MSH2 P43246 R711K 711 R K 0.784 Pathogenic MSH2 P43246 R711L 711 R L 0.994 Pathogenic MSH2 P43246 R711M 711 R M 0.8 Pathogenic MSH2 P43246 R711N 711 R N 0.674 Pathogenic MSH2 P43246 R711P 711 R P 0.992 Pathogenic MSH2 P43246 R711Q 711 R Q 0.542 Pathogenic MSH2 P43246 R711S 711 R S 0.924 Pathogenic MSH2 P43246 R711T 711 R T 0.958 Pathogenic MSH2 P43246 R711V 711 R V 0.98 Pathogenic MSH2 P43246 R711W 711 R W 0.96 Pathogenic MSH2 P43246 R711Y 711 R Y 0.97 Pathogenic MSH2 P43246 V712A 712 V A 0.524 Pathogenic MSH2 P43246 V712C 712 V C 0.808 Pathogenic MSH2 P43246 V712D 712 V D 0.864 Pathogenic MSH2 P43246 V712E 712 V E 0.958 Pathogenic MSH2 P43246 V712F 712 V F 0.93 Pathogenic MSH2 P43246 V712G 712 V G 0.916 Pathogenic MSH2 P43246 V712H 712 V H 0.91 Pathogenic MSH2 P43246 V712I 712 V I 0.424 Neutral MSH2 P43246 V712K 712 V K 0.982 Pathogenic MSH2 P43246 V712L 712 V L 0.688 Pathogenic MSH2 P43246 V712M 712 V M 0.918 Pathogenic MSH2 P43246 V712N 712 V N 0.92 Pathogenic MSH2 P43246 V712P 712 V P 0.99 Pathogenic MSH2 P43246 V712Q 712 V Q 0.964 Pathogenic MSH2 P43246 V712R 712 V R 0.95 Pathogenic MSH2 P43246 V712S 712 V S 0.81 Pathogenic MSH2 P43246 V712T 712 V T 0.878 Pathogenic MSH2 P43246 V712W 712 V W 0.954 Pathogenic MSH2 P43246 V712Y 712 V Y 0.974 Pathogenic MSH2 P43246 G713A 713 G A 0.966 Pathogenic MSH2 P43246 G713C 713 G C 0.948 Pathogenic MSH2 P43246 G713D 713 G D 1 Pathogenic MSH2 P43246 G713E 713 G E 0.988 Pathogenic MSH2 P43246 G713F 713 G F 0.984 Pathogenic MSH2 P43246 G713H 713 G H 0.988 Pathogenic MSH2 P43246 G713I 713 G I 0.974 Pathogenic MSH2 P43246 G713K 713 G K 0.988 Pathogenic MSH2 P43246 G713L 713 G L 0.984 Pathogenic MSH2 P43246 G713M 713 G M 0.994 Pathogenic MSH2 P43246 G713N 713 G N 0.986 Pathogenic MSH2 P43246 G713P 713 G P 0.966 Pathogenic MSH2 P43246 G713Q 713 G Q 0.994 Pathogenic MSH2 P43246 G713R 713 G R 1 Pathogenic MSH2 P43246 G713S 713 G S 0.832 Pathogenic MSH2 P43246 G713T 713 G T 0.846 Pathogenic MSH2 P43246 G713V 713 G V 0.986 Pathogenic MSH2 P43246 G713W 713 G W 0.98 Pathogenic MSH2 P43246 G713Y 713 G Y 0.96 Pathogenic MSH2 P43246 A714C 714 A C 0.74 Pathogenic MSH2 P43246 A714D 714 A D 0.93 Pathogenic MSH2 P43246 A714E 714 A E 0.884 Pathogenic MSH2 P43246 A714F 714 A F 0.97 Pathogenic MSH2 P43246 A714G 714 A G 0.766 Pathogenic MSH2 P43246 A714H 714 A H 0.872 Pathogenic MSH2 P43246 A714I 714 A I 0.962 Pathogenic MSH2 P43246 A714K 714 A K 0.94 Pathogenic MSH2 P43246 A714L 714 A L 0.984 Pathogenic MSH2 P43246 A714M 714 A M 0.86 Pathogenic MSH2 P43246 A714N 714 A N 0.864 Pathogenic MSH2 P43246 A714P 714 A P 0.964 Pathogenic MSH2 P43246 A714Q 714 A Q 0.824 Pathogenic MSH2 P43246 A714R 714 A R 0.962 Pathogenic MSH2 P43246 A714S 714 A S 0.344 Neutral MSH2 P43246 A714T 714 A T 0.744 Pathogenic MSH2 P43246 A714V 714 A V 0.914 Pathogenic MSH2 P43246 A714W 714 A W 0.98 Pathogenic MSH2 P43246 A714Y 714 A Y 0.966 Pathogenic MSH2 P43246 G715A 715 G A 0.402 Neutral MSH2 P43246 G715C 715 G C 0.94 Pathogenic MSH2 P43246 G715D 715 G D 0.558 Pathogenic MSH2 P43246 G715E 715 G E 0.694 Pathogenic MSH2 P43246 G715F 715 G F 0.988 Pathogenic MSH2 P43246 G715H 715 G H 0.992 Pathogenic MSH2 P43246 G715I 715 G I 0.978 Pathogenic MSH2 P43246 G715K 715 G K 0.992 Pathogenic MSH2 P43246 G715L 715 G L 0.988 Pathogenic MSH2 P43246 G715M 715 G M 0.994 Pathogenic MSH2 P43246 G715N 715 G N 0.528 Pathogenic MSH2 P43246 G715P 715 G P 0.982 Pathogenic MSH2 P43246 G715Q 715 G Q 0.988 Pathogenic MSH2 P43246 G715R 715 G R 1 Pathogenic MSH2 P43246 G715S 715 G S 0.296 Neutral MSH2 P43246 G715T 715 G T 0.92 Pathogenic MSH2 P43246 G715V 715 G V 0.99 Pathogenic MSH2 P43246 G715W 715 G W 0.984 Pathogenic MSH2 P43246 G715Y 715 G Y 0.986 Pathogenic MSH2 P43246 D716A 716 D A 0.794 Pathogenic MSH2 P43246 D716C 716 D C 0.89 Pathogenic MSH2 P43246 D716E 716 D E 0.82 Pathogenic MSH2 P43246 D716F 716 D F 0.978 Pathogenic MSH2 P43246 D716G 716 D G 0.956 Pathogenic MSH2 P43246 D716H 716 D H 0.638 Pathogenic MSH2 P43246 D716I 716 D I 0.972 Pathogenic MSH2 P43246 D716K 716 D K 0.928 Pathogenic MSH2 P43246 D716L 716 D L 0.978 Pathogenic MSH2 P43246 D716M 716 D M 0.956 Pathogenic MSH2 P43246 D716N 716 D N 0.868 Pathogenic MSH2 P43246 D716P 716 D P 0.91 Pathogenic MSH2 P43246 D716Q 716 D Q 0.64 Pathogenic MSH2 P43246 D716R 716 D R 0.958 Pathogenic MSH2 P43246 D716S 716 D S 0.594 Pathogenic MSH2 P43246 D716T 716 D T 0.808 Pathogenic MSH2 P43246 D716V 716 D V 0.992 Pathogenic MSH2 P43246 D716W 716 D W 0.982 Pathogenic MSH2 P43246 D716Y 716 D Y 0.976 Pathogenic MSH2 P43246 S717A 717 S A 0.862 Pathogenic MSH2 P43246 S717C 717 S C 0.304 Neutral MSH2 P43246 S717D 717 S D 0.904 Pathogenic MSH2 P43246 S717E 717 S E 0.958 Pathogenic MSH2 P43246 S717F 717 S F 0.982 Pathogenic MSH2 P43246 S717G 717 S G 0.688 Pathogenic MSH2 P43246 S717H 717 S H 0.974 Pathogenic MSH2 P43246 S717I 717 S I 0.884 Pathogenic MSH2 P43246 S717K 717 S K 0.954 Pathogenic MSH2 P43246 S717L 717 S L 0.924 Pathogenic MSH2 P43246 S717M 717 S M 0.998 Pathogenic MSH2 P43246 S717N 717 S N 0.27 Neutral MSH2 P43246 S717P 717 S P 0.97 Pathogenic MSH2 P43246 S717Q 717 S Q 0.948 Pathogenic MSH2 P43246 S717R 717 S R 0.736 Pathogenic MSH2 P43246 S717T 717 S T 0.806 Pathogenic MSH2 P43246 S717V 717 S V 0.958 Pathogenic MSH2 P43246 S717W 717 S W 0.952 Pathogenic MSH2 P43246 S717Y 717 S Y 0.876 Pathogenic MSH2 P43246 Q718A 718 Q A 0.784 Pathogenic MSH2 P43246 Q718C 718 Q C 0.76 Pathogenic MSH2 P43246 Q718D 718 Q D 0.852 Pathogenic MSH2 P43246 Q718E 718 Q E 0.57 Pathogenic MSH2 P43246 Q718F 718 Q F 0.876 Pathogenic MSH2 P43246 Q718G 718 Q G 0.536 Pathogenic MSH2 P43246 Q718H 718 Q H 0.804 Pathogenic MSH2 P43246 Q718I 718 Q I 0.604 Pathogenic MSH2 P43246 Q718K 718 Q K 0.9 Pathogenic MSH2 P43246 Q718L 718 Q L 0.552 Pathogenic MSH2 P43246 Q718M 718 Q M 0.89 Pathogenic MSH2 P43246 Q718N 718 Q N 0.892 Pathogenic MSH2 P43246 Q718P 718 Q P 0.726 Pathogenic MSH2 P43246 Q718R 718 Q R 0.924 Pathogenic MSH2 P43246 Q718S 718 Q S 0.418 Neutral MSH2 P43246 Q718T 718 Q T 0.374 Neutral MSH2 P43246 Q718V 718 Q V 0.924 Pathogenic MSH2 P43246 Q718W 718 Q W 0.952 Pathogenic MSH2 P43246 Q718Y 718 Q Y 0.94 Pathogenic MSH2 P43246 L719A 719 L A 0.156 Neutral MSH2 P43246 L719C 719 L C 0.762 Pathogenic MSH2 P43246 L719D 719 L D 0.886 Pathogenic MSH2 P43246 L719E 719 L E 0.866 Pathogenic MSH2 P43246 L719F 719 L F 0.788 Pathogenic MSH2 P43246 L719G 719 L G 0.8 Pathogenic MSH2 P43246 L719H 719 L H 0.876 Pathogenic MSH2 P43246 L719I 719 L I 0.194 Neutral MSH2 P43246 L719K 719 L K 0.754 Pathogenic MSH2 P43246 L719M 719 L M 0.182 Neutral MSH2 P43246 L719N 719 L N 0.264 Neutral MSH2 P43246 L719P 719 L P 0.992 Pathogenic MSH2 P43246 L719Q 719 L Q 0.688 Pathogenic MSH2 P43246 L719R 719 L R 0.708 Pathogenic MSH2 P43246 L719S 719 L S 0.15 Neutral MSH2 P43246 L719T 719 L T 0.126 Neutral MSH2 P43246 L719V 719 L V 0.08 Neutral MSH2 P43246 L719W 719 L W 0.942 Pathogenic MSH2 P43246 L719Y 719 L Y 0.904 Pathogenic MSH2 P43246 A72C 72 A C 0.356 Neutral MSH2 P43246 A72D 72 A D 0.436 Neutral MSH2 P43246 A72E 72 A E 0.374 Neutral MSH2 P43246 A72F 72 A F 0.714 Pathogenic MSH2 P43246 A72G 72 A G 0.004 Neutral MSH2 P43246 A72H 72 A H 0.494 Neutral MSH2 P43246 A72I 72 A I 0.542 Pathogenic MSH2 P43246 A72K 72 A K 0.36 Neutral MSH2 P43246 A72L 72 A L 0.426 Neutral MSH2 P43246 A72M 72 A M 0.46 Neutral MSH2 P43246 A72N 72 A N 0.39 Neutral MSH2 P43246 A72P 72 A P 0.06 Neutral MSH2 P43246 A72Q 72 A Q 0.342 Neutral MSH2 P43246 A72R 72 A R 0.408 Neutral MSH2 P43246 A72S 72 A S 0.004 Neutral MSH2 P43246 A72T 72 A T 0.02 Neutral MSH2 P43246 A72V 72 A V 0.368 Neutral MSH2 P43246 A72W 72 A W 0.748 Pathogenic MSH2 P43246 A72Y 72 A Y 0.752 Pathogenic MSH2 P43246 K720A 720 K A 0.688 Pathogenic MSH2 P43246 K720C 720 K C 0.57 Pathogenic MSH2 P43246 K720D 720 K D 0.758 Pathogenic MSH2 P43246 K720E 720 K E 0.858 Pathogenic MSH2 P43246 K720F 720 K F 0.942 Pathogenic MSH2 P43246 K720G 720 K G 0.53 Pathogenic MSH2 P43246 K720H 720 K H 0.39 Neutral MSH2 P43246 K720I 720 K I 0.728 Pathogenic MSH2 P43246 K720L 720 K L 0.968 Pathogenic MSH2 P43246 K720M 720 K M 0.848 Pathogenic MSH2 P43246 K720N 720 K N 0.772 Pathogenic MSH2 P43246 K720P 720 K P 0.908 Pathogenic MSH2 P43246 K720Q 720 K Q 0.252 Neutral MSH2 P43246 K720R 720 K R 0.256 Neutral MSH2 P43246 K720S 720 K S 0.6 Pathogenic MSH2 P43246 K720T 720 K T 0.634 Pathogenic MSH2 P43246 K720V 720 K V 0.842 Pathogenic MSH2 P43246 K720W 720 K W 0.976 Pathogenic MSH2 P43246 K720Y 720 K Y 0.962 Pathogenic MSH2 P43246 G721A 721 G A 0.966 Pathogenic MSH2 P43246 G721C 721 G C 0.948 Pathogenic MSH2 P43246 G721D 721 G D 1 Pathogenic MSH2 P43246 G721E 721 G E 0.988 Pathogenic MSH2 P43246 G721F 721 G F 0.984 Pathogenic MSH2 P43246 G721H 721 G H 0.988 Pathogenic MSH2 P43246 G721I 721 G I 0.974 Pathogenic MSH2 P43246 G721K 721 G K 0.988 Pathogenic MSH2 P43246 G721L 721 G L 0.984 Pathogenic MSH2 P43246 G721M 721 G M 0.994 Pathogenic MSH2 P43246 G721N 721 G N 0.986 Pathogenic MSH2 P43246 G721P 721 G P 0.966 Pathogenic MSH2 P43246 G721Q 721 G Q 0.994 Pathogenic MSH2 P43246 G721R 721 G R 1 Pathogenic MSH2 P43246 G721S 721 G S 0.832 Pathogenic MSH2 P43246 G721T 721 G T 0.846 Pathogenic MSH2 P43246 G721V 721 G V 0.986 Pathogenic MSH2 P43246 G721W 721 G W 0.98 Pathogenic MSH2 P43246 G721Y 721 G Y 0.96 Pathogenic MSH2 P43246 V722A 722 V A 0.498 Neutral MSH2 P43246 V722C 722 V C 0.792 Pathogenic MSH2 P43246 V722D 722 V D 0.846 Pathogenic MSH2 P43246 V722E 722 V E 0.952 Pathogenic MSH2 P43246 V722F 722 V F 0.932 Pathogenic MSH2 P43246 V722G 722 V G 0.924 Pathogenic MSH2 P43246 V722H 722 V H 0.896 Pathogenic MSH2 P43246 V722I 722 V I 0.244 Neutral 1 MSH2 P43246 V722K 722 V K 0.97 Pathogenic MSH2 P43246 V722L 722 V L 0.276 Neutral MSH2 P43246 V722M 722 V M 0.488 Neutral MSH2 P43246 V722N 722 V N 0.906 Pathogenic MSH2 P43246 V722P 722 V P 0.98 Pathogenic MSH2 P43246 V722Q 722 V Q 0.96 Pathogenic MSH2 P43246 V722R 722 V R 0.944 Pathogenic MSH2 P43246 V722S 722 V S 0.8 Pathogenic MSH2 P43246 V722T 722 V T 0.874 Pathogenic MSH2 P43246 V722W 722 V W 0.956 Pathogenic MSH2 P43246 V722Y 722 V Y 0.976 Pathogenic MSH2 P43246 S723A 723 S A 0.872 Pathogenic MSH2 P43246 S723C 723 S C 0.906 Pathogenic MSH2 P43246 S723D 723 S D 0.914 Pathogenic MSH2 P43246 S723E 723 S E 0.964 Pathogenic MSH2 P43246 S723F 723 S F 0.982 Pathogenic MSH2 P43246 S723G 723 S G 0.7 Pathogenic MSH2 P43246 S723H 723 S H 0.974 Pathogenic MSH2 P43246 S723I 723 S I 0.886 Pathogenic MSH2 P43246 S723K 723 S K 0.954 Pathogenic MSH2 P43246 S723L 723 S L 0.926 Pathogenic MSH2 P43246 S723M 723 S M 0.998 Pathogenic MSH2 P43246 S723N 723 S N 0.892 Pathogenic MSH2 P43246 S723P 723 S P 0.97 Pathogenic MSH2 P43246 S723Q 723 S Q 0.952 Pathogenic MSH2 P43246 S723R 723 S R 0.974 Pathogenic MSH2 P43246 S723T 723 S T 0.762 Pathogenic MSH2 P43246 S723V 723 S V 0.958 Pathogenic MSH2 P43246 S723W 723 S W 0.956 Pathogenic MSH2 P43246 S723Y 723 S Y 0.964 Pathogenic MSH2 P43246 T724A 724 T A 0.72 Pathogenic MSH2 P43246 T724C 724 T C 0.942 Pathogenic MSH2 P43246 T724D 724 T D 0.956 Pathogenic MSH2 P43246 T724E 724 T E 0.952 Pathogenic MSH2 P43246 T724F 724 T F 0.95 Pathogenic MSH2 P43246 T724G 724 T G 0.758 Pathogenic MSH2 P43246 T724H 724 T H 0.926 Pathogenic MSH2 P43246 T724I 724 T I 0.952 Pathogenic MSH2 P43246 T724K 724 T K 0.94 Pathogenic MSH2 P43246 T724L 724 T L 0.952 Pathogenic MSH2 P43246 T724M 724 T M 0.984 Pathogenic MSH2 P43246 T724N 724 T N 0.908 Pathogenic MSH2 P43246 T724P 724 T P 0.968 Pathogenic MSH2 P43246 T724Q 724 T Q 0.896 Pathogenic MSH2 P43246 T724R 724 T R 0.994 Pathogenic MSH2 P43246 T724S 724 T S 0.504 Pathogenic MSH2 P43246 T724V 724 T V 0.85 Pathogenic MSH2 P43246 T724W 724 T W 0.978 Pathogenic MSH2 P43246 T724Y 724 T Y 0.978 Pathogenic MSH2 P43246 F725A 725 F A 0.506 Pathogenic MSH2 P43246 F725C 725 F C 0.734 Pathogenic MSH2 P43246 F725D 725 F D 0.826 Pathogenic MSH2 P43246 F725E 725 F E 0.878 Pathogenic MSH2 P43246 F725G 725 F G 0.508 Pathogenic MSH2 P43246 F725H 725 F H 0.786 Pathogenic MSH2 P43246 F725I 725 F I 0.694 Pathogenic MSH2 P43246 F725K 725 F K 0.858 Pathogenic MSH2 P43246 F725L 725 F L 0.708 Pathogenic MSH2 P43246 F725M 725 F M 0.8 Pathogenic MSH2 P43246 F725N 725 F N 0.774 Pathogenic MSH2 P43246 F725P 725 F P 0.954 Pathogenic MSH2 P43246 F725Q 725 F Q 0.794 Pathogenic MSH2 P43246 F725R 725 F R 0.922 Pathogenic MSH2 P43246 F725S 725 F S 0.882 Pathogenic MSH2 P43246 F725T 725 F T 0.61 Pathogenic MSH2 P43246 F725V 725 F V 0.766 Pathogenic MSH2 P43246 F725W 725 F W 0.874 Pathogenic MSH2 P43246 F725Y 725 F Y 0.588 Pathogenic MSH2 P43246 M726A 726 M A 0.712 Pathogenic MSH2 P43246 M726C 726 M C 0.664 Pathogenic MSH2 P43246 M726D 726 M D 0.896 Pathogenic MSH2 P43246 M726E 726 M E 0.85 Pathogenic MSH2 P43246 M726F 726 M F 0.82 Pathogenic MSH2 P43246 M726G 726 M G 0.528 Pathogenic MSH2 P43246 M726H 726 M H 0.956 Pathogenic MSH2 P43246 M726I 726 M I 0.856 Pathogenic MSH2 P43246 M726K 726 M K 0.966 Pathogenic MSH2 P43246 M726L 726 M L 0.84 Pathogenic MSH2 P43246 M726N 726 M N 0.918 Pathogenic MSH2 P43246 M726P 726 M P 0.94 Pathogenic MSH2 P43246 M726Q 726 M Q 0.816 Pathogenic MSH2 P43246 M726R 726 M R 0.964 Pathogenic MSH2 P43246 M726S 726 M S 0.914 Pathogenic MSH2 P43246 M726T 726 M T 0.794 Pathogenic MSH2 P43246 M726V 726 M V 0.656 Pathogenic MSH2 P43246 M726W 726 M W 0.97 Pathogenic MSH2 P43246 M726Y 726 M Y 0.966 Pathogenic MSH2 P43246 A727C 727 A C 0.974 Pathogenic MSH2 P43246 A727D 727 A D 0.958 Pathogenic MSH2 P43246 A727E 727 A E 0.976 Pathogenic MSH2 P43246 A727F 727 A F 0.994 Pathogenic MSH2 P43246 A727G 727 A G 0.366 Neutral MSH2 P43246 A727H 727 A H 0.942 Pathogenic MSH2 P43246 A727I 727 A I 0.928 Pathogenic MSH2 P43246 A727K 727 A K 0.972 Pathogenic MSH2 P43246 A727L 727 A L 1 Pathogenic MSH2 P43246 A727M 727 A M 0.642 Pathogenic MSH2 P43246 A727N 727 A N 0.652 Pathogenic MSH2 P43246 A727P 727 A P 0.974 Pathogenic MSH2 P43246 A727Q 727 A Q 0.492 Neutral MSH2 P43246 A727R 727 A R 0.982 Pathogenic MSH2 P43246 A727S 727 A S 0.132 Neutral MSH2 P43246 A727T 727 A T 0.286 Neutral MSH2 P43246 A727V 727 A V 0.438 Neutral MSH2 P43246 A727W 727 A W 0.996 Pathogenic MSH2 P43246 A727Y 727 A Y 0.97 Pathogenic MSH2 P43246 E728A 728 E A 0.812 Pathogenic MSH2 P43246 E728C 728 E C 0.77 Pathogenic MSH2 P43246 E728D 728 E D 0.894 Pathogenic MSH2 P43246 E728F 728 E F 0.962 Pathogenic MSH2 P43246 E728G 728 E G 0.342 Neutral MSH2 P43246 E728H 728 E H 0.76 Pathogenic MSH2 P43246 E728I 728 E I 0.98 Pathogenic MSH2 P43246 E728K 728 E K 0.928 Pathogenic MSH2 P43246 E728L 728 E L 0.976 Pathogenic MSH2 P43246 E728M 728 E M 0.92 Pathogenic MSH2 P43246 E728N 728 E N 0.8 Pathogenic MSH2 P43246 E728P 728 E P 0.944 Pathogenic MSH2 P43246 E728Q 728 E Q 0.87 Pathogenic MSH2 P43246 E728R 728 E R 0.936 Pathogenic MSH2 P43246 E728S 728 E S 0.916 Pathogenic MSH2 P43246 E728T 728 E T 0.86 Pathogenic MSH2 P43246 E728V 728 E V 0.926 Pathogenic MSH2 P43246 E728W 728 E W 0.982 Pathogenic MSH2 P43246 E728Y 728 E Y 0.96 Pathogenic MSH2 P43246 M729A 729 M A 0.712 Pathogenic MSH2 P43246 M729C 729 M C 0.664 Pathogenic MSH2 P43246 M729D 729 M D 0.896 Pathogenic MSH2 P43246 M729E 729 M E 0.85 Pathogenic MSH2 P43246 M729F 729 M F 0.82 Pathogenic MSH2 P43246 M729G 729 M G 0.528 Pathogenic MSH2 P43246 M729H 729 M H 0.956 Pathogenic MSH2 P43246 M729I 729 M I 0.652 Pathogenic MSH2 P43246 M729K 729 M K 0.966 Pathogenic MSH2 P43246 M729L 729 M L 0.84 Pathogenic MSH2 P43246 M729N 729 M N 0.918 Pathogenic MSH2 P43246 M729P 729 M P 0.94 Pathogenic MSH2 P43246 M729Q 729 M Q 0.816 Pathogenic MSH2 P43246 M729R 729 M R 0.964 Pathogenic MSH2 P43246 M729S 729 M S 0.914 Pathogenic MSH2 P43246 M729T 729 M T 0.794 Pathogenic MSH2 P43246 M729V 729 M V 0.656 Pathogenic MSH2 P43246 M729W 729 M W 0.97 Pathogenic MSH2 P43246 M729Y 729 M Y 0.966 Pathogenic MSH2 P43246 K73A 73 K A 0.066 Neutral MSH2 P43246 K73C 73 K C 0.168 Neutral MSH2 P43246 K73D 73 K D 0.186 Neutral MSH2 P43246 K73E 73 K E 0.02 Neutral MSH2 P43246 K73F 73 K F 0.768 Pathogenic MSH2 P43246 K73G 73 K G 0.092 Neutral MSH2 P43246 K73H 73 K H 0.268 Neutral MSH2 P43246 K73I 73 K I 0.818 Pathogenic MSH2 P43246 K73L 73 K L 0.704 Pathogenic MSH2 P43246 K73M 73 K M 0.592 Pathogenic MSH2 P43246 K73N 73 K N 0.03 Neutral MSH2 P43246 K73P 73 K P 0.082 Neutral MSH2 P43246 K73Q 73 K Q 0.03 Neutral MSH2 P43246 K73R 73 K R 0.016 Neutral MSH2 P43246 K73S 73 K S 0.03 Neutral MSH2 P43246 K73T 73 K T 0.024 Neutral MSH2 P43246 K73V 73 K V 0.724 Pathogenic MSH2 P43246 K73W 73 K W 0.948 Pathogenic MSH2 P43246 K73Y 73 K Y 0.884 Pathogenic MSH2 P43246 L730A 730 L A 0.714 Pathogenic MSH2 P43246 L730C 730 L C 0.816 Pathogenic MSH2 P43246 L730D 730 L D 0.9 Pathogenic MSH2 P43246 L730E 730 L E 0.882 Pathogenic MSH2 P43246 L730F 730 L F 0.856 Pathogenic MSH2 P43246 L730G 730 L G 0.87 Pathogenic MSH2 P43246 L730H 730 L H 0.906 Pathogenic MSH2 P43246 L730I 730 L I 0.258 Neutral MSH2 P43246 L730K 730 L K 0.71 Pathogenic MSH2 P43246 L730M 730 L M 0.588 Pathogenic MSH2 P43246 L730N 730 L N 0.81 Pathogenic MSH2 P43246 L730P 730 L P 0.978 Pathogenic MSH2 P43246 L730Q 730 L Q 0.442 Neutral MSH2 P43246 L730R 730 L R 0.982 Pathogenic MSH2 P43246 L730S 730 L S 0.698 Pathogenic MSH2 P43246 L730T 730 L T 0.614 Pathogenic MSH2 P43246 L730V 730 L V 0.11 Neutral MSH2 P43246 L730W 730 L W 0.862 Pathogenic MSH2 P43246 L730Y 730 L Y 0.878 Pathogenic MSH2 P43246 E731A 731 E A 0.812 Pathogenic MSH2 P43246 E731C 731 E C 0.77 Pathogenic MSH2 P43246 E731D 731 E D 0.52 Pathogenic MSH2 P43246 E731F 731 E F 0.962 Pathogenic MSH2 P43246 E731G 731 E G 0.336 Neutral MSH2 P43246 E731H 731 E H 0.76 Pathogenic MSH2 P43246 E731I 731 E I 0.98 Pathogenic MSH2 P43246 E731K 731 E K 0.928 Pathogenic MSH2 P43246 E731L 731 E L 0.976 Pathogenic MSH2 P43246 E731M 731 E M 0.92 Pathogenic MSH2 P43246 E731N 731 E N 0.796 Pathogenic MSH2 P43246 E731P 731 E P 0.944 Pathogenic MSH2 P43246 E731Q 731 E Q 0.866 Pathogenic MSH2 P43246 E731R 731 E R 0.936 Pathogenic MSH2 P43246 E731S 731 E S 0.914 Pathogenic MSH2 P43246 E731T 731 E T 0.86 Pathogenic MSH2 P43246 E731V 731 E V 0.926 Pathogenic MSH2 P43246 E731W 731 E W 0.982 Pathogenic MSH2 P43246 E731Y 731 E Y 0.96 Pathogenic MSH2 P43246 T732A 732 T A 0.716 Pathogenic MSH2 P43246 T732C 732 T C 0.67 Pathogenic MSH2 P43246 T732D 732 T D 0.952 Pathogenic MSH2 P43246 T732E 732 T E 0.95 Pathogenic MSH2 P43246 T732F 732 T F 0.948 Pathogenic MSH2 P43246 T732G 732 T G 0.744 Pathogenic MSH2 P43246 T732H 732 T H 0.924 Pathogenic MSH2 P43246 T732I 732 T I 0.55 Pathogenic MSH2 P43246 T732K 732 T K 0.938 Pathogenic MSH2 P43246 T732L 732 T L 0.95 Pathogenic MSH2 P43246 T732M 732 T M 0.708 Pathogenic MSH2 P43246 T732N 732 T N 0.896 Pathogenic MSH2 P43246 T732P 732 T P 0.966 Pathogenic MSH2 P43246 T732Q 732 T Q 0.892 Pathogenic MSH2 P43246 T732R 732 T R 0.992 Pathogenic MSH2 P43246 T732S 732 T S 0.502 Pathogenic MSH2 P43246 T732V 732 T V 0.844 Pathogenic MSH2 P43246 T732W 732 T W 0.974 Pathogenic MSH2 P43246 T732Y 732 T Y 0.974 Pathogenic MSH2 P43246 A733C 733 A C 0.81 Pathogenic MSH2 P43246 A733D 733 A D 0.9 Pathogenic MSH2 P43246 A733E 733 A E 0.846 Pathogenic MSH2 P43246 A733F 733 A F 0.942 Pathogenic MSH2 P43246 A733G 733 A G 0.71 Pathogenic MSH2 P43246 A733H 733 A H 0.836 Pathogenic MSH2 P43246 A733I 733 A I 0.942 Pathogenic MSH2 P43246 A733K 733 A K 0.91 Pathogenic MSH2 P43246 A733L 733 A L 0.954 Pathogenic MSH2 P43246 A733M 733 A M 0.822 Pathogenic MSH2 P43246 A733N 733 A N 0.83 Pathogenic MSH2 P43246 A733P 733 A P 0.95 Pathogenic MSH2 P43246 A733Q 733 A Q 0.784 Pathogenic MSH2 P43246 A733R 733 A R 0.944 Pathogenic MSH2 P43246 A733S 733 A S 0.132 Neutral MSH2 P43246 A733T 733 A T 0.68 Pathogenic MSH2 P43246 A733V 733 A V 0.886 Pathogenic MSH2 P43246 A733W 733 A W 0.952 Pathogenic MSH2 P43246 A733Y 733 A Y 0.948 Pathogenic MSH2 P43246 S734A 734 S A 0.046 Neutral MSH2 P43246 S734C 734 S C 0.54 Pathogenic MSH2 P43246 S734D 734 S D 0.578 Pathogenic MSH2 P43246 S734E 734 S E 0.766 Pathogenic MSH2 P43246 S734F 734 S F 0.678 Pathogenic MSH2 P43246 S734G 734 S G 0.022 Neutral MSH2 P43246 S734H 734 S H 0.826 Pathogenic MSH2 P43246 S734I 734 S I 0.656 Pathogenic MSH2 P43246 S734K 734 S K 0.77 Pathogenic MSH2 P43246 S734L 734 S L 0.674 Pathogenic MSH2 P43246 S734M 734 S M 0.97 Pathogenic MSH2 P43246 S734N 734 S N 0.068 Neutral MSH2 P43246 S734P 734 S P 0.686 Pathogenic MSH2 P43246 S734Q 734 S Q 0.718 Pathogenic MSH2 P43246 S734R 734 S R 0.832 Pathogenic MSH2 P43246 S734T 734 S T 0.048 Neutral MSH2 P43246 S734V 734 S V 0.13 Neutral MSH2 P43246 S734W 734 S W 0.932 Pathogenic MSH2 P43246 S734Y 734 S Y 0.654 Pathogenic MSH2 P43246 I735A 735 I A 0.652 Pathogenic MSH2 P43246 I735C 735 I C 0.748 Pathogenic MSH2 P43246 I735D 735 I D 0.818 Pathogenic MSH2 P43246 I735E 735 I E 0.816 Pathogenic MSH2 P43246 I735F 735 I F 0.852 Pathogenic MSH2 P43246 I735G 735 I G 0.872 Pathogenic MSH2 P43246 I735H 735 I H 0.644 Pathogenic MSH2 P43246 I735K 735 I K 0.852 Pathogenic MSH2 P43246 I735L 735 I L 0.598 Pathogenic MSH2 P43246 I735M 735 I M 0.682 Pathogenic MSH2 P43246 I735N 735 I N 0.84 Pathogenic MSH2 P43246 I735P 735 I P 0.936 Pathogenic MSH2 P43246 I735Q 735 I Q 0.844 Pathogenic MSH2 P43246 I735R 735 I R 0.9 Pathogenic MSH2 P43246 I735S 735 I S 0.732 Pathogenic MSH2 P43246 I735T 735 I T 0.372 Neutral MSH2 P43246 I735V 735 I V 0.572 Pathogenic MSH2 P43246 I735W 735 I W 0.904 Pathogenic MSH2 P43246 I735Y 735 I Y 0.88 Pathogenic MSH2 P43246 L736A 736 L A 0.714 Pathogenic MSH2 P43246 L736C 736 L C 0.822 Pathogenic MSH2 P43246 L736D 736 L D 0.91 Pathogenic MSH2 P43246 L736E 736 L E 0.894 Pathogenic MSH2 P43246 L736F 736 L F 0.87 Pathogenic MSH2 P43246 L736G 736 L G 0.864 Pathogenic MSH2 P43246 L736H 736 L H 0.91 Pathogenic MSH2 P43246 L736I 736 L I 0.42 Neutral MSH2 P43246 L736K 736 L K 0.724 Pathogenic MSH2 P43246 L736M 736 L M 0.468 Neutral MSH2 P43246 L736N 736 L N 0.82 Pathogenic MSH2 P43246 L736P 736 L P 0.99 Pathogenic MSH2 P43246 L736Q 736 L Q 0.776 Pathogenic MSH2 P43246 L736R 736 L R 0.986 Pathogenic MSH2 P43246 L736S 736 L S 0.706 Pathogenic MSH2 P43246 L736T 736 L T 0.448 Neutral MSH2 P43246 L736V 736 L V 0.268 Neutral MSH2 P43246 L736W 736 L W 0.874 Pathogenic MSH2 P43246 L736Y 736 L Y 0.886 Pathogenic MSH2 P43246 R737A 737 R A 0.58 Pathogenic MSH2 P43246 R737C 737 R C 0.956 Pathogenic MSH2 P43246 R737D 737 R D 0.848 Pathogenic MSH2 P43246 R737E 737 R E 0.846 Pathogenic MSH2 P43246 R737F 737 R F 0.974 Pathogenic MSH2 P43246 R737G 737 R G 0.436 Neutral MSH2 P43246 R737H 737 R H 0.542 Pathogenic MSH2 P43246 R737I 737 R I 0.976 Pathogenic MSH2 P43246 R737K 737 R K 0.528 Pathogenic MSH2 P43246 R737L 737 R L 0.988 Pathogenic MSH2 P43246 R737M 737 R M 0.8 Pathogenic MSH2 P43246 R737N 737 R N 0.168 Neutral MSH2 P43246 R737P 737 R P 0.988 Pathogenic MSH2 P43246 R737Q 737 R Q 0.102 Neutral MSH2 P43246 R737S 737 R S 0.206 Neutral MSH2 P43246 R737T 737 R T 0.944 Pathogenic MSH2 P43246 R737V 737 R V 0.976 Pathogenic MSH2 P43246 R737W 737 R W 0.968 Pathogenic MSH2 P43246 R737Y 737 R Y 0.972 Pathogenic MSH2 P43246 S738A 738 S A 0.144 Neutral MSH2 P43246 S738C 738 S C 0.704 Pathogenic MSH2 P43246 S738D 738 S D 0.738 Pathogenic MSH2 P43246 S738E 738 S E 0.872 Pathogenic MSH2 P43246 S738F 738 S F 0.966 Pathogenic MSH2 P43246 S738G 738 S G 0.084 Neutral MSH2 P43246 S738H 738 S H 0.902 Pathogenic MSH2 P43246 S738I 738 S I 0.802 Pathogenic MSH2 P43246 S738K 738 S K 0.862 Pathogenic MSH2 P43246 S738L 738 S L 0.828 Pathogenic MSH2 P43246 S738M 738 S M 0.864 Pathogenic MSH2 P43246 S738N 738 S N 0.18 Neutral MSH2 P43246 S738P 738 S P 0.568 Pathogenic MSH2 P43246 S738Q 738 S Q 0.572 Pathogenic MSH2 P43246 S738R 738 S R 0.616 Pathogenic MSH2 P43246 S738T 738 S T 0.27 Neutral MSH2 P43246 S738V 738 S V 0.486 Neutral MSH2 P43246 S738W 738 S W 0.932 Pathogenic MSH2 P43246 S738Y 738 S Y 0.93 Pathogenic MSH2 P43246 A739C 739 A C 0.862 Pathogenic MSH2 P43246 A739D 739 A D 0.922 Pathogenic MSH2 P43246 A739E 739 A E 0.876 Pathogenic MSH2 P43246 A739F 739 A F 0.966 Pathogenic MSH2 P43246 A739G 739 A G 0.482 Neutral MSH2 P43246 A739H 739 A H 0.866 Pathogenic MSH2 P43246 A739I 739 A I 0.958 Pathogenic MSH2 P43246 A739K 739 A K 0.936 Pathogenic MSH2 P43246 A739L 739 A L 0.98 Pathogenic MSH2 P43246 A739M 739 A M 0.852 Pathogenic MSH2 P43246 A739N 739 A N 0.854 Pathogenic MSH2 P43246 A739P 739 A P 0.966 Pathogenic MSH2 P43246 A739Q 739 A Q 0.648 Pathogenic MSH2 P43246 A739R 739 A R 0.954 Pathogenic MSH2 P43246 A739S 739 A S 0.322 Neutral MSH2 P43246 A739T 739 A T 0.734 Pathogenic MSH2 P43246 A739V 739 A V 0.91 Pathogenic MSH2 P43246 A739W 739 A W 0.976 Pathogenic MSH2 P43246 A739Y 739 A Y 0.962 Pathogenic MSH2 P43246 N74A 74 N A 0.314 Neutral MSH2 P43246 N74C 74 N C 0.518 Pathogenic MSH2 P43246 N74D 74 N D 0.512 Pathogenic MSH2 P43246 N74E 74 N E 0.454 Neutral MSH2 P43246 N74F 74 N F 0.87 Pathogenic MSH2 P43246 N74G 74 N G 0.546 Pathogenic MSH2 P43246 N74H 74 N H 0.698 Pathogenic MSH2 P43246 N74I 74 N I 0.366 Neutral MSH2 P43246 N74K 74 N K 0.128 Neutral MSH2 P43246 N74L 74 N L 0.32 Neutral MSH2 P43246 N74M 74 N M 0.804 Pathogenic MSH2 P43246 N74P 74 N P 0.696 Pathogenic MSH2 P43246 N74Q 74 N Q 0.592 Pathogenic MSH2 P43246 N74R 74 N R 0.49 Neutral MSH2 P43246 N74S 74 N S 0.568 Pathogenic MSH2 P43246 N74T 74 N T 0.038 Neutral MSH2 P43246 N74V 74 N V 0.162 Neutral MSH2 P43246 N74W 74 N W 0.916 Pathogenic MSH2 P43246 N74Y 74 N Y 0.904 Pathogenic MSH2 P43246 T740A 740 T A 0.694 Pathogenic MSH2 P43246 T740C 740 T C 0.922 Pathogenic MSH2 P43246 T740D 740 T D 0.356 Neutral MSH2 P43246 T740E 740 T E 0.934 Pathogenic MSH2 P43246 T740F 740 T F 0.948 Pathogenic MSH2 P43246 T740G 740 T G 0.73 Pathogenic MSH2 P43246 T740H 740 T H 0.916 Pathogenic MSH2 P43246 T740I 740 T I 0.64 Pathogenic MSH2 P43246 T740K 740 T K 0.934 Pathogenic MSH2 P43246 T740L 740 T L 0.94 Pathogenic MSH2 P43246 T740M 740 T M 0.974 Pathogenic MSH2 P43246 T740N 740 T N 0.872 Pathogenic MSH2 P43246 T740P 740 T P 0.956 Pathogenic MSH2 P43246 T740Q 740 T Q 0.876 Pathogenic MSH2 P43246 T740R 740 T R 0.994 Pathogenic MSH2 P43246 T740S 740 T S 0.17 Neutral MSH2 P43246 T740V 740 T V 0.79 Pathogenic MSH2 P43246 T740W 740 T W 0.952 Pathogenic MSH2 P43246 T740Y 740 T Y 0.952 Pathogenic MSH2 P43246 K741A 741 K A 0.086 Neutral MSH2 P43246 K741C 741 K C 0.034 Neutral MSH2 P43246 K741D 741 K D 0.028 Neutral MSH2 P43246 K741E 741 K E 0.03 Neutral MSH2 P43246 K741F 741 K F 0.774 Pathogenic MSH2 P43246 K741G 741 K G 0.322 Neutral MSH2 P43246 K741H 741 K H 0.28 Neutral MSH2 P43246 K741I 741 K I 0.826 Pathogenic MSH2 P43246 K741L 741 K L 0.708 Pathogenic MSH2 P43246 K741M 741 K M 0.56 Pathogenic MSH2 P43246 K741N 741 K N 0.182 Neutral MSH2 P43246 K741P 741 K P 0.104 Neutral MSH2 P43246 K741Q 741 K Q 0.044 Neutral MSH2 P43246 K741R 741 K R 0.03 Neutral MSH2 P43246 K741S 741 K S 0.026 Neutral MSH2 P43246 K741T 741 K T 0.256 Neutral MSH2 P43246 K741V 741 K V 0.248 Neutral MSH2 P43246 K741W 741 K W 0.95 Pathogenic MSH2 P43246 K741Y 741 K Y 0.888 Pathogenic MSH2 P43246 D742A 742 D A 0.528 Pathogenic MSH2 P43246 D742C 742 D C 0.628 Pathogenic MSH2 P43246 D742E 742 D E 0.038 Neutral MSH2 P43246 D742F 742 D F 0.952 Pathogenic MSH2 P43246 D742G 742 D G 0.498 Neutral MSH2 P43246 D742H 742 D H 0.512 Pathogenic MSH2 P43246 D742I 742 D I 0.924 Pathogenic MSH2 P43246 D742K 742 D K 0.05 Neutral MSH2 P43246 D742L 742 D L 0.924 Pathogenic MSH2 P43246 D742M 742 D M 0.834 Pathogenic MSH2 P43246 D742N 742 D N 0.004 Neutral MSH2 P43246 D742P 742 D P 0.818 Pathogenic MSH2 P43246 D742Q 742 D Q 0.494 Neutral MSH2 P43246 D742R 742 D R 0.5 Pathogenic MSH2 P43246 D742S 742 D S 0.012 Neutral MSH2 P43246 D742T 742 D T 0.052 Neutral MSH2 P43246 D742V 742 D V 0.948 Pathogenic MSH2 P43246 D742W 742 D W 0.97 Pathogenic MSH2 P43246 D742Y 742 D Y 0.934 Pathogenic MSH2 P43246 S743A 743 S A 0.472 Neutral MSH2 P43246 S743C 743 S C 0.906 Pathogenic MSH2 P43246 S743D 743 S D 0.914 Pathogenic MSH2 P43246 S743E 743 S E 0.664 Pathogenic MSH2 P43246 S743F 743 S F 0.982 Pathogenic MSH2 P43246 S743G 743 S G 0.424 Neutral MSH2 P43246 S743H 743 S H 0.974 Pathogenic MSH2 P43246 S743I 743 S I 0.886 Pathogenic MSH2 P43246 S743K 743 S K 0.954 Pathogenic MSH2 P43246 S743L 743 S L 0.926 Pathogenic MSH2 P43246 S743M 743 S M 0.998 Pathogenic MSH2 P43246 S743N 743 S N 0.892 Pathogenic MSH2 P43246 S743P 743 S P 0.97 Pathogenic MSH2 P43246 S743Q 743 S Q 0.952 Pathogenic MSH2 P43246 S743R 743 S R 0.974 Pathogenic MSH2 P43246 S743T 743 S T 0.754 Pathogenic MSH2 P43246 S743V 743 S V 0.954 Pathogenic MSH2 P43246 S743W 743 S W 0.954 Pathogenic MSH2 P43246 S743Y 743 S Y 0.962 Pathogenic MSH2 P43246 L744A 744 L A 0.718 Pathogenic MSH2 P43246 L744C 744 L C 0.834 Pathogenic MSH2 P43246 L744D 744 L D 0.916 Pathogenic MSH2 P43246 L744E 744 L E 0.898 Pathogenic MSH2 P43246 L744F 744 L F 0.884 Pathogenic MSH2 P43246 L744G 744 L G 0.864 Pathogenic MSH2 P43246 L744H 744 L H 0.91 Pathogenic MSH2 P43246 L744I 744 L I 0.94 Pathogenic MSH2 P43246 L744K 744 L K 0.738 Pathogenic MSH2 P43246 L744M 744 L M 0.628 Pathogenic MSH2 P43246 L744N 744 L N 0.826 Pathogenic MSH2 P43246 L744P 744 L P 0.99 Pathogenic MSH2 P43246 L744Q 744 L Q 0.782 Pathogenic MSH2 P43246 L744R 744 L R 0.982 Pathogenic MSH2 P43246 L744S 744 L S 0.72 Pathogenic MSH2 P43246 L744T 744 L T 0.642 Pathogenic MSH2 P43246 L744V 744 L V 0.46 Neutral MSH2 P43246 L744W 744 L W 0.886 Pathogenic MSH2 P43246 L744Y 744 L Y 0.896 Pathogenic MSH2 P43246 I745A 745 I A 0.632 Pathogenic MSH2 P43246 I745C 745 I C 0.71 Pathogenic MSH2 P43246 I745D 745 I D 0.778 Pathogenic MSH2 P43246 I745E 745 I E 0.512 Pathogenic MSH2 P43246 I745F 745 I F 0.79 Pathogenic MSH2 P43246 I745G 745 I G 0.856 Pathogenic MSH2 P43246 I745H 745 I H 0.89 Pathogenic MSH2 P43246 I745K 745 I K 0.82 Pathogenic MSH2 P43246 I745L 745 I L 0.494 Neutral MSH2 P43246 I745M 745 I M 0.352 Neutral MSH2 P43246 I745N 745 I N 0.798 Pathogenic MSH2 P43246 I745P 745 I P 0.902 Pathogenic MSH2 P43246 I745Q 745 I Q 0.806 Pathogenic MSH2 P43246 I745R 745 I R 0.884 Pathogenic MSH2 P43246 I745S 745 I S 0.672 Pathogenic MSH2 P43246 I745T 745 I T 0.192 Neutral MSH2 P43246 I745V 745 I V 0.092 Neutral MSH2 P43246 I745W 745 I W 0.864 Pathogenic MSH2 P43246 I745Y 745 I Y 0.84 Pathogenic MSH2 P43246 I746A 746 I A 0.646 Pathogenic MSH2 P43246 I746C 746 I C 0.538 Pathogenic MSH2 P43246 I746D 746 I D 0.812 Pathogenic MSH2 P43246 I746E 746 I E 0.812 Pathogenic MSH2 P43246 I746F 746 I F 0.844 Pathogenic MSH2 P43246 I746G 746 I G 0.872 Pathogenic MSH2 P43246 I746H 746 I H 0.908 Pathogenic MSH2 P43246 I746K 746 I K 0.846 Pathogenic MSH2 P43246 I746L 746 I L 0.292 Neutral MSH2 P43246 I746M 746 I M 0.498 Neutral MSH2 P43246 I746N 746 I N 0.834 Pathogenic MSH2 P43246 I746P 746 I P 0.93 Pathogenic MSH2 P43246 I746Q 746 I Q 0.84 Pathogenic MSH2 P43246 I746R 746 I R 0.746 Pathogenic MSH2 P43246 I746S 746 I S 0.708 Pathogenic MSH2 P43246 I746T 746 I T 0.346 Neutral MSH2 P43246 I746V 746 I V 0.316 Neutral MSH2 P43246 I746W 746 I W 0.896 Pathogenic MSH2 P43246 I746Y 746 I Y 0.872 Pathogenic MSH2 P43246 I747A 747 I A 0.646 Pathogenic MSH2 P43246 I747C 747 I C 0.738 Pathogenic MSH2 P43246 I747D 747 I D 0.812 Pathogenic MSH2 P43246 I747E 747 I E 0.812 Pathogenic MSH2 P43246 I747F 747 I F 0.844 Pathogenic MSH2 P43246 I747G 747 I G 0.872 Pathogenic MSH2 P43246 I747H 747 I H 0.908 Pathogenic MSH2 P43246 I747K 747 I K 0.846 Pathogenic MSH2 P43246 I747L 747 I L 0.572 Pathogenic MSH2 P43246 I747M 747 I M 0.66 Pathogenic MSH2 P43246 I747N 747 I N 0.834 Pathogenic MSH2 P43246 I747P 747 I P 0.93 Pathogenic MSH2 P43246 I747Q 747 I Q 0.84 Pathogenic MSH2 P43246 I747R 747 I R 0.902 Pathogenic MSH2 P43246 I747S 747 I S 0.708 Pathogenic MSH2 P43246 I747T 747 I T 0.346 Neutral MSH2 P43246 I747V 747 I V 0.282 Neutral MSH2 P43246 I747W 747 I W 0.896 Pathogenic MSH2 P43246 I747Y 747 I Y 0.872 Pathogenic MSH2 P43246 D748A 748 D A 0.572 Pathogenic MSH2 P43246 D748C 748 D C 0.89 Pathogenic MSH2 P43246 D748E 748 D E 0.82 Pathogenic MSH2 P43246 D748F 748 D F 0.978 Pathogenic MSH2 P43246 D748G 748 D G 0.956 Pathogenic MSH2 P43246 D748H 748 D H 0.638 Pathogenic MSH2 P43246 D748I 748 D I 0.972 Pathogenic MSH2 P43246 D748K 748 D K 0.928 Pathogenic MSH2 P43246 D748L 748 D L 0.978 Pathogenic MSH2 P43246 D748M 748 D M 0.956 Pathogenic MSH2 P43246 D748N 748 D N 0.868 Pathogenic MSH2 P43246 D748P 748 D P 0.91 Pathogenic MSH2 P43246 D748Q 748 D Q 0.64 Pathogenic MSH2 P43246 D748R 748 D R 0.958 Pathogenic MSH2 P43246 D748S 748 D S 0.594 Pathogenic MSH2 P43246 D748T 748 D T 0.808 Pathogenic MSH2 P43246 D748V 748 D V 0.992 Pathogenic MSH2 P43246 D748W 748 D W 0.982 Pathogenic MSH2 P43246 D748Y 748 D Y 0.976 Pathogenic MSH2 P43246 E749A 749 E A 0.812 Pathogenic MSH2 P43246 E749C 749 E C 0.77 Pathogenic MSH2 P43246 E749D 749 E D 0.894 Pathogenic MSH2 P43246 E749F 749 E F 0.962 Pathogenic MSH2 P43246 E749G 749 E G 0.342 Neutral MSH2 P43246 E749H 749 E H 0.76 Pathogenic MSH2 P43246 E749I 749 E I 0.98 Pathogenic MSH2 P43246 E749K 749 E K 0.928 Pathogenic 4 MSH2 P43246 E749L 749 E L 0.976 Pathogenic MSH2 P43246 E749M 749 E M 0.92 Pathogenic MSH2 P43246 E749N 749 E N 0.8 Pathogenic MSH2 P43246 E749P 749 E P 0.944 Pathogenic MSH2 P43246 E749Q 749 E Q 0.87 Pathogenic MSH2 P43246 E749R 749 E R 0.936 Pathogenic MSH2 P43246 E749S 749 E S 0.508 Pathogenic MSH2 P43246 E749T 749 E T 0.86 Pathogenic MSH2 P43246 E749V 749 E V 0.926 Pathogenic MSH2 P43246 E749W 749 E W 0.982 Pathogenic MSH2 P43246 E749Y 749 E Y 0.96 Pathogenic MSH2 P43246 L75A 75 L A 0.038 Neutral MSH2 P43246 L75C 75 L C 0.326 Neutral MSH2 P43246 L75D 75 L D 0.09 Neutral MSH2 P43246 L75E 75 L E 0.066 Neutral MSH2 P43246 L75F 75 L F 0.79 Pathogenic MSH2 P43246 L75G 75 L G 0.534 Pathogenic MSH2 P43246 L75H 75 L H 0.346 Neutral MSH2 P43246 L75I 75 L I 0.238 Neutral MSH2 P43246 L75K 75 L K 0.042 Neutral MSH2 P43246 L75M 75 L M 0.452 Neutral MSH2 P43246 L75N 75 L N 0.516 Pathogenic MSH2 P43246 L75P 75 L P 0.224 Neutral MSH2 P43246 L75Q 75 L Q 0.036 Neutral MSH2 P43246 L75R 75 L R 0.856 Pathogenic MSH2 P43246 L75S 75 L S 0.044 Neutral MSH2 P43246 L75T 75 L T 0.222 Neutral MSH2 P43246 L75V 75 L V 0.194 Neutral MSH2 P43246 L75W 75 L W 0.866 Pathogenic MSH2 P43246 L75Y 75 L Y 0.862 Pathogenic MSH2 P43246 L750A 750 L A 0.718 Pathogenic MSH2 P43246 L750C 750 L C 0.834 Pathogenic MSH2 P43246 L750D 750 L D 0.916 Pathogenic MSH2 P43246 L750E 750 L E 0.898 Pathogenic MSH2 P43246 L750F 750 L F 0.884 Pathogenic MSH2 P43246 L750G 750 L G 0.864 Pathogenic MSH2 P43246 L750H 750 L H 0.91 Pathogenic MSH2 P43246 L750I 750 L I 0.94 Pathogenic MSH2 P43246 L750K 750 L K 0.738 Pathogenic MSH2 P43246 L750M 750 L M 0.628 Pathogenic MSH2 P43246 L750N 750 L N 0.826 Pathogenic MSH2 P43246 L750P 750 L P 0.862 Pathogenic MSH2 P43246 L750Q 750 L Q 0.782 Pathogenic MSH2 P43246 L750R 750 L R 0.982 Pathogenic MSH2 P43246 L750S 750 L S 0.72 Pathogenic MSH2 P43246 L750T 750 L T 0.642 Pathogenic MSH2 P43246 L750V 750 L V 0.46 Neutral MSH2 P43246 L750W 750 L W 0.886 Pathogenic MSH2 P43246 L750Y 750 L Y 0.896 Pathogenic MSH2 P43246 G751A 751 G A 0.966 Pathogenic MSH2 P43246 G751C 751 G C 0.948 Pathogenic MSH2 P43246 G751D 751 G D 1 Pathogenic MSH2 P43246 G751E 751 G E 0.988 Pathogenic MSH2 P43246 G751F 751 G F 0.984 Pathogenic MSH2 P43246 G751H 751 G H 0.988 Pathogenic MSH2 P43246 G751I 751 G I 0.974 Pathogenic MSH2 P43246 G751K 751 G K 0.988 Pathogenic MSH2 P43246 G751L 751 G L 0.984 Pathogenic MSH2 P43246 G751M 751 G M 0.994 Pathogenic MSH2 P43246 G751N 751 G N 0.986 Pathogenic MSH2 P43246 G751P 751 G P 0.966 Pathogenic MSH2 P43246 G751Q 751 G Q 0.994 Pathogenic MSH2 P43246 G751R 751 G R 1 Pathogenic 5 MSH2 P43246 G751S 751 G S 0.832 Pathogenic MSH2 P43246 G751T 751 G T 0.846 Pathogenic MSH2 P43246 G751V 751 G V 0.986 Pathogenic MSH2 P43246 G751W 751 G W 0.98 Pathogenic MSH2 P43246 G751Y 751 G Y 0.96 Pathogenic MSH2 P43246 R752A 752 R A 0.574 Pathogenic MSH2 P43246 R752C 752 R C 0.96 Pathogenic MSH2 P43246 R752D 752 R D 0.714 Pathogenic MSH2 P43246 R752E 752 R E 0.814 Pathogenic MSH2 P43246 R752F 752 R F 0.976 Pathogenic MSH2 P43246 R752G 752 R G 0.404 Neutral MSH2 P43246 R752H 752 R H 0.432 Neutral MSH2 P43246 R752I 752 R I 0.98 Pathogenic MSH2 P43246 R752K 752 R K 0.784 Pathogenic MSH2 P43246 R752L 752 R L 0.78 Pathogenic MSH2 P43246 R752M 752 R M 0.8 Pathogenic MSH2 P43246 R752N 752 R N 0.674 Pathogenic MSH2 P43246 R752P 752 R P 0.992 Pathogenic MSH2 P43246 R752Q 752 R Q 0.542 Pathogenic MSH2 P43246 R752S 752 R S 0.924 Pathogenic MSH2 P43246 R752T 752 R T 0.958 Pathogenic MSH2 P43246 R752V 752 R V 0.98 Pathogenic MSH2 P43246 R752W 752 R W 0.96 Pathogenic MSH2 P43246 R752Y 752 R Y 0.97 Pathogenic MSH2 P43246 G753A 753 G A 0.966 Pathogenic MSH2 P43246 G753C 753 G C 0.948 Pathogenic MSH2 P43246 G753D 753 G D 1 Pathogenic MSH2 P43246 G753E 753 G E 0.988 Pathogenic MSH2 P43246 G753F 753 G F 0.984 Pathogenic MSH2 P43246 G753H 753 G H 0.988 Pathogenic MSH2 P43246 G753I 753 G I 0.974 Pathogenic MSH2 P43246 G753K 753 G K 0.988 Pathogenic MSH2 P43246 G753L 753 G L 0.984 Pathogenic MSH2 P43246 G753M 753 G M 0.994 Pathogenic MSH2 P43246 G753N 753 G N 0.986 Pathogenic MSH2 P43246 G753P 753 G P 0.966 Pathogenic MSH2 P43246 G753Q 753 G Q 0.994 Pathogenic MSH2 P43246 G753R 753 G R 1 Pathogenic MSH2 P43246 G753S 753 G S 0.832 Pathogenic MSH2 P43246 G753T 753 G T 0.846 Pathogenic MSH2 P43246 G753V 753 G V 0.986 Pathogenic MSH2 P43246 G753W 753 G W 0.98 Pathogenic MSH2 P43246 G753Y 753 G Y 0.96 Pathogenic MSH2 P43246 T754A 754 T A 0.72 Pathogenic MSH2 P43246 T754C 754 T C 0.942 Pathogenic MSH2 P43246 T754D 754 T D 0.956 Pathogenic MSH2 P43246 T754E 754 T E 0.952 Pathogenic MSH2 P43246 T754F 754 T F 0.95 Pathogenic MSH2 P43246 T754G 754 T G 0.758 Pathogenic MSH2 P43246 T754H 754 T H 0.926 Pathogenic MSH2 P43246 T754I 754 T I 0.952 Pathogenic MSH2 P43246 T754K 754 T K 0.94 Pathogenic MSH2 P43246 T754L 754 T L 0.952 Pathogenic MSH2 P43246 T754M 754 T M 0.984 Pathogenic MSH2 P43246 T754N 754 T N 0.908 Pathogenic MSH2 P43246 T754P 754 T P 0.968 Pathogenic MSH2 P43246 T754Q 754 T Q 0.896 Pathogenic MSH2 P43246 T754R 754 T R 0.994 Pathogenic MSH2 P43246 T754S 754 T S 0.504 Pathogenic MSH2 P43246 T754V 754 T V 0.85 Pathogenic MSH2 P43246 T754W 754 T W 0.978 Pathogenic MSH2 P43246 T754Y 754 T Y 0.978 Pathogenic MSH2 P43246 S755A 755 S A 0.872 Pathogenic MSH2 P43246 S755C 755 S C 0.906 Pathogenic MSH2 P43246 S755D 755 S D 0.914 Pathogenic MSH2 P43246 S755E 755 S E 0.964 Pathogenic MSH2 P43246 S755F 755 S F 0.982 Pathogenic MSH2 P43246 S755G 755 S G 0.7 Pathogenic MSH2 P43246 S755H 755 S H 0.974 Pathogenic MSH2 P43246 S755I 755 S I 0.886 Pathogenic MSH2 P43246 S755K 755 S K 0.954 Pathogenic MSH2 P43246 S755L 755 S L 0.812 Pathogenic MSH2 P43246 S755M 755 S M 0.998 Pathogenic MSH2 P43246 S755N 755 S N 0.892 Pathogenic MSH2 P43246 S755P 755 S P 0.97 Pathogenic MSH2 P43246 S755Q 755 S Q 0.952 Pathogenic MSH2 P43246 S755R 755 S R 0.974 Pathogenic MSH2 P43246 S755T 755 S T 0.762 Pathogenic MSH2 P43246 S755V 755 S V 0.958 Pathogenic MSH2 P43246 S755W 755 S W 0.956 Pathogenic MSH2 P43246 S755Y 755 S Y 0.964 Pathogenic MSH2 P43246 T756A 756 T A 0.72 Pathogenic MSH2 P43246 T756C 756 T C 0.942 Pathogenic MSH2 P43246 T756D 756 T D 0.956 Pathogenic MSH2 P43246 T756E 756 T E 0.952 Pathogenic MSH2 P43246 T756F 756 T F 0.95 Pathogenic MSH2 P43246 T756G 756 T G 0.758 Pathogenic MSH2 P43246 T756H 756 T H 0.926 Pathogenic MSH2 P43246 T756I 756 T I 0.712 Pathogenic MSH2 P43246 T756K 756 T K 0.94 Pathogenic MSH2 P43246 T756L 756 T L 0.952 Pathogenic MSH2 P43246 T756M 756 T M 0.984 Pathogenic MSH2 P43246 T756N 756 T N 0.908 Pathogenic MSH2 P43246 T756P 756 T P 0.968 Pathogenic MSH2 P43246 T756Q 756 T Q 0.896 Pathogenic MSH2 P43246 T756R 756 T R 0.994 Pathogenic MSH2 P43246 T756S 756 T S 0.84 Pathogenic MSH2 P43246 T756V 756 T V 0.85 Pathogenic MSH2 P43246 T756W 756 T W 0.978 Pathogenic MSH2 P43246 T756Y 756 T Y 0.978 Pathogenic MSH2 P43246 Y757A 757 Y A 0.382 Neutral MSH2 P43246 Y757C 757 Y C 0.688 Pathogenic MSH2 P43246 Y757D 757 Y D 0.842 Pathogenic MSH2 P43246 Y757E 757 Y E 0.752 Pathogenic MSH2 P43246 Y757F 757 Y F 0.406 Neutral MSH2 P43246 Y757G 757 Y G 0.476 Neutral MSH2 P43246 Y757H 757 Y H 0.612 Pathogenic MSH2 P43246 Y757I 757 Y I 0.798 Pathogenic MSH2 P43246 Y757K 757 Y K 0.816 Pathogenic MSH2 P43246 Y757L 757 Y L 0.71 Pathogenic MSH2 P43246 Y757M 757 Y M 0.688 Pathogenic MSH2 P43246 Y757N 757 Y N 0.744 Pathogenic MSH2 P43246 Y757P 757 Y P 0.78 Pathogenic MSH2 P43246 Y757Q 757 Y Q 0.664 Pathogenic MSH2 P43246 Y757R 757 Y R 0.786 Pathogenic MSH2 P43246 Y757S 757 Y S 0.476 Neutral MSH2 P43246 Y757T 757 Y T 0.474 Neutral MSH2 P43246 Y757V 757 Y V 0.658 Pathogenic MSH2 P43246 Y757W 757 Y W 0.662 Pathogenic MSH2 P43246 D758A 758 D A 0.79 Pathogenic MSH2 P43246 D758C 758 D C 0.882 Pathogenic MSH2 P43246 D758E 758 D E 0.388 Neutral MSH2 P43246 D758F 758 D F 0.98 Pathogenic MSH2 P43246 D758G 758 D G 0.94 Pathogenic MSH2 P43246 D758H 758 D H 0.62 Pathogenic MSH2 P43246 D758I 758 D I 0.974 Pathogenic MSH2 P43246 D758K 758 D K 0.814 Pathogenic MSH2 P43246 D758L 758 D L 0.978 Pathogenic MSH2 P43246 D758M 758 D M 0.956 Pathogenic MSH2 P43246 D758N 758 D N 0.852 Pathogenic MSH2 P43246 D758P 758 D P 0.902 Pathogenic MSH2 P43246 D758Q 758 D Q 0.606 Pathogenic MSH2 P43246 D758R 758 D R 0.958 Pathogenic MSH2 P43246 D758S 758 D S 0.556 Pathogenic MSH2 P43246 D758T 758 D T 0.796 Pathogenic MSH2 P43246 D758V 758 D V 0.996 Pathogenic MSH2 P43246 D758W 758 D W 0.982 Pathogenic MSH2 P43246 D758Y 758 D Y 0.974 Pathogenic MSH2 P43246 G759A 759 G A 0.966 Pathogenic MSH2 P43246 G759C 759 G C 0.948 Pathogenic MSH2 P43246 G759D 759 G D 1 Pathogenic MSH2 P43246 G759E 759 G E 0.988 Pathogenic MSH2 P43246 G759F 759 G F 0.984 Pathogenic MSH2 P43246 G759H 759 G H 0.988 Pathogenic MSH2 P43246 G759I 759 G I 0.974 Pathogenic MSH2 P43246 G759K 759 G K 0.988 Pathogenic MSH2 P43246 G759L 759 G L 0.984 Pathogenic MSH2 P43246 G759M 759 G M 0.994 Pathogenic MSH2 P43246 G759N 759 G N 0.986 Pathogenic MSH2 P43246 G759P 759 G P 0.966 Pathogenic MSH2 P43246 G759Q 759 G Q 0.994 Pathogenic MSH2 P43246 G759R 759 G R 0.924 Pathogenic MSH2 P43246 G759S 759 G S 0.832 Pathogenic MSH2 P43246 G759T 759 G T 0.846 Pathogenic MSH2 P43246 G759V 759 G V 0.986 Pathogenic MSH2 P43246 G759W 759 G W 0.98 Pathogenic MSH2 P43246 G759Y 759 G Y 0.96 Pathogenic MSH2 P43246 Q76A 76 Q A 0.23 Neutral MSH2 P43246 Q76C 76 Q C 0.304 Neutral MSH2 P43246 Q76D 76 Q D 0.33 Neutral MSH2 P43246 Q76E 76 Q E 0.022 Neutral MSH2 P43246 Q76F 76 Q F 0.356 Neutral MSH2 P43246 Q76G 76 Q G 0.11 Neutral MSH2 P43246 Q76H 76 Q H 0.778 Pathogenic MSH2 P43246 Q76I 76 Q I 0.896 Pathogenic MSH2 P43246 Q76K 76 Q K 0.79 Pathogenic MSH2 P43246 Q76L 76 Q L 0.758 Pathogenic MSH2 P43246 Q76M 76 Q M 0.742 Pathogenic MSH2 P43246 Q76N 76 Q N 0.596 Pathogenic MSH2 P43246 Q76P 76 Q P 0.802 Pathogenic MSH2 P43246 Q76R 76 Q R 0.584 Pathogenic MSH2 P43246 Q76S 76 Q S 0.278 Neutral MSH2 P43246 Q76T 76 Q T 0.036 Neutral MSH2 P43246 Q76V 76 Q V 0.712 Pathogenic MSH2 P43246 Q76W 76 Q W 0.93 Pathogenic MSH2 P43246 Q76Y 76 Q Y 0.494 Neutral MSH2 P43246 F760A 760 F A 0.502 Pathogenic MSH2 P43246 F760C 760 F C 0.346 Neutral MSH2 P43246 F760D 760 F D 0.822 Pathogenic MSH2 P43246 F760E 760 F E 0.872 Pathogenic MSH2 P43246 F760G 760 F G 0.518 Pathogenic MSH2 P43246 F760H 760 F H 0.77 Pathogenic MSH2 P43246 F760I 760 F I 0.68 Pathogenic MSH2 P43246 F760K 760 F K 0.85 Pathogenic MSH2 P43246 F760L 760 F L 0.42 Neutral MSH2 P43246 F760M 760 F M 0.788 Pathogenic MSH2 P43246 F760N 760 F N 0.772 Pathogenic MSH2 P43246 F760P 760 F P 0.958 Pathogenic MSH2 P43246 F760Q 760 F Q 0.79 Pathogenic MSH2 P43246 F760R 760 F R 0.694 Pathogenic MSH2 P43246 F760S 760 F S 0.888 Pathogenic MSH2 P43246 F760T 760 F T 0.596 Pathogenic MSH2 P43246 F760V 760 F V 0.74 Pathogenic MSH2 P43246 F760W 760 F W 0.864 Pathogenic MSH2 P43246 F760Y 760 F Y 0.552 Pathogenic MSH2 P43246 G761A 761 G A 0.966 Pathogenic MSH2 P43246 G761C 761 G C 0.948 Pathogenic MSH2 P43246 G761D 761 G D 1 Pathogenic MSH2 P43246 G761E 761 G E 0.988 Pathogenic MSH2 P43246 G761F 761 G F 0.984 Pathogenic MSH2 P43246 G761H 761 G H 0.988 Pathogenic MSH2 P43246 G761I 761 G I 0.974 Pathogenic MSH2 P43246 G761K 761 G K 0.988 Pathogenic MSH2 P43246 G761L 761 G L 0.984 Pathogenic MSH2 P43246 G761M 761 G M 0.994 Pathogenic MSH2 P43246 G761N 761 G N 0.986 Pathogenic MSH2 P43246 G761P 761 G P 0.966 Pathogenic MSH2 P43246 G761Q 761 G Q 0.994 Pathogenic MSH2 P43246 G761R 761 G R 1 Pathogenic MSH2 P43246 G761S 761 G S 0.832 Pathogenic MSH2 P43246 G761T 761 G T 0.846 Pathogenic MSH2 P43246 G761V 761 G V 0.986 Pathogenic MSH2 P43246 G761W 761 G W 0.98 Pathogenic MSH2 P43246 G761Y 761 G Y 0.96 Pathogenic MSH2 P43246 L762A 762 L A 0.714 Pathogenic MSH2 P43246 L762C 762 L C 0.822 Pathogenic MSH2 P43246 L762D 762 L D 0.91 Pathogenic MSH2 P43246 L762E 762 L E 0.896 Pathogenic MSH2 P43246 L762F 762 L F 0.872 Pathogenic MSH2 P43246 L762G 762 L G 0.864 Pathogenic MSH2 P43246 L762H 762 L H 0.91 Pathogenic MSH2 P43246 L762I 762 L I 0.396 Neutral MSH2 P43246 L762K 762 L K 0.728 Pathogenic MSH2 P43246 L762M 762 L M 0.602 Pathogenic MSH2 P43246 L762N 762 L N 0.82 Pathogenic MSH2 P43246 L762P 762 L P 0.992 Pathogenic MSH2 P43246 L762Q 762 L Q 0.776 Pathogenic MSH2 P43246 L762R 762 L R 0.986 Pathogenic MSH2 P43246 L762S 762 L S 0.706 Pathogenic MSH2 P43246 L762T 762 L T 0.626 Pathogenic MSH2 P43246 L762V 762 L V 0.424 Neutral MSH2 P43246 L762W 762 L W 0.878 Pathogenic MSH2 P43246 L762Y 762 L Y 0.89 Pathogenic MSH2 P43246 A763C 763 A C 0.732 Pathogenic MSH2 P43246 A763D 763 A D 0.93 Pathogenic MSH2 P43246 A763E 763 A E 0.884 Pathogenic MSH2 P43246 A763F 763 A F 0.97 Pathogenic MSH2 P43246 A763G 763 A G 0.77 Pathogenic MSH2 P43246 A763H 763 A H 0.872 Pathogenic MSH2 P43246 A763I 763 A I 0.962 Pathogenic MSH2 P43246 A763K 763 A K 0.94 Pathogenic MSH2 P43246 A763L 763 A L 0.984 Pathogenic MSH2 P43246 A763M 763 A M 0.86 Pathogenic MSH2 P43246 A763N 763 A N 0.864 Pathogenic MSH2 P43246 A763P 763 A P 0.966 Pathogenic 4 MSH2 P43246 A763Q 763 A Q 0.824 Pathogenic MSH2 P43246 A763R 763 A R 0.962 Pathogenic MSH2 P43246 A763S 763 A S 0.424 Neutral MSH2 P43246 A763T 763 A T 0.744 Pathogenic MSH2 P43246 A763V 763 A V 0.914 Pathogenic MSH2 P43246 A763W 763 A W 0.98 Pathogenic MSH2 P43246 A763Y 763 A Y 0.966 Pathogenic MSH2 P43246 W764A 764 W A 0.466 Neutral MSH2 P43246 W764C 764 W C 0.47 Neutral MSH2 P43246 W764D 764 W D 0.496 Neutral MSH2 P43246 W764E 764 W E 0.84 Pathogenic MSH2 P43246 W764F 764 W F 0.402 Neutral MSH2 P43246 W764G 764 W G 0.466 Neutral MSH2 P43246 W764H 764 W H 0.722 Pathogenic MSH2 P43246 W764I 764 W I 0.534 Pathogenic MSH2 P43246 W764K 764 W K 0.892 Pathogenic MSH2 P43246 W764L 764 W L 0.388 Neutral MSH2 P43246 W764M 764 W M 0.72 Pathogenic MSH2 P43246 W764N 764 W N 0.476 Neutral MSH2 P43246 W764P 764 W P 0.494 Neutral MSH2 P43246 W764Q 764 W Q 0.656 Pathogenic MSH2 P43246 W764R 764 W R 0.734 Pathogenic MSH2 P43246 W764S 764 W S 0.476 Neutral MSH2 P43246 W764T 764 W T 0.466 Neutral MSH2 P43246 W764V 764 W V 0.406 Neutral MSH2 P43246 W764Y 764 W Y 0.394 Neutral MSH2 P43246 A765C 765 A C 0.838 Pathogenic MSH2 P43246 A765D 765 A D 0.916 Pathogenic MSH2 P43246 A765E 765 A E 0.864 Pathogenic MSH2 P43246 A765F 765 A F 0.956 Pathogenic MSH2 P43246 A765G 765 A G 0.164 Neutral MSH2 P43246 A765H 765 A H 0.722 Pathogenic MSH2 P43246 A765I 765 A I 0.95 Pathogenic MSH2 P43246 A765K 765 A K 0.924 Pathogenic MSH2 P43246 A765L 765 A L 0.968 Pathogenic MSH2 P43246 A765M 765 A M 0.836 Pathogenic MSH2 P43246 A765N 765 A N 0.852 Pathogenic MSH2 P43246 A765P 765 A P 0.96 Pathogenic MSH2 P43246 A765Q 765 A Q 0.804 Pathogenic MSH2 P43246 A765R 765 A R 0.952 Pathogenic MSH2 P43246 A765S 765 A S 0.134 Neutral MSH2 P43246 A765T 765 A T 0.712 Pathogenic MSH2 P43246 A765V 765 A V 0.898 Pathogenic MSH2 P43246 A765W 765 A W 0.964 Pathogenic MSH2 P43246 A765Y 765 A Y 0.954 Pathogenic MSH2 P43246 I766A 766 I A 0.652 Pathogenic MSH2 P43246 I766C 766 I C 0.744 Pathogenic MSH2 P43246 I766D 766 I D 0.814 Pathogenic MSH2 P43246 I766E 766 I E 0.812 Pathogenic MSH2 P43246 I766F 766 I F 0.852 Pathogenic MSH2 P43246 I766G 766 I G 0.872 Pathogenic MSH2 P43246 I766H 766 I H 0.528 Pathogenic MSH2 P43246 I766K 766 I K 0.848 Pathogenic MSH2 P43246 I766L 766 I L 0.412 Neutral MSH2 P43246 I766M 766 I M 0.678 Pathogenic MSH2 P43246 I766N 766 I N 0.836 Pathogenic MSH2 P43246 I766P 766 I P 0.932 Pathogenic MSH2 P43246 I766Q 766 I Q 0.84 Pathogenic MSH2 P43246 I766R 766 I R 0.9 Pathogenic MSH2 P43246 I766S 766 I S 0.728 Pathogenic MSH2 P43246 I766T 766 I T 0.368 Neutral MSH2 P43246 I766V 766 I V 0.568 Pathogenic MSH2 P43246 I766W 766 I W 0.904 Pathogenic MSH2 P43246 I766Y 766 I Y 0.88 Pathogenic MSH2 P43246 S767A 767 S A 0.206 Neutral MSH2 P43246 S767C 767 S C 0.302 Neutral MSH2 P43246 S767D 767 S D 0.904 Pathogenic MSH2 P43246 S767E 767 S E 0.958 Pathogenic MSH2 P43246 S767F 767 S F 0.982 Pathogenic MSH2 P43246 S767G 767 S G 0.686 Pathogenic MSH2 P43246 S767H 767 S H 0.974 Pathogenic MSH2 P43246 S767I 767 S I 0.884 Pathogenic MSH2 P43246 S767K 767 S K 0.954 Pathogenic MSH2 P43246 S767L 767 S L 0.924 Pathogenic MSH2 P43246 S767M 767 S M 0.998 Pathogenic MSH2 P43246 S767N 767 S N 0.888 Pathogenic MSH2 P43246 S767P 767 S P 0.97 Pathogenic MSH2 P43246 S767Q 767 S Q 0.948 Pathogenic MSH2 P43246 S767R 767 S R 0.972 Pathogenic MSH2 P43246 S767T 767 S T 0.782 Pathogenic MSH2 P43246 S767V 767 S V 0.958 Pathogenic MSH2 P43246 S767W 767 S W 0.948 Pathogenic MSH2 P43246 S767Y 767 S Y 0.956 Pathogenic MSH2 P43246 E768A 768 E A 0.808 Pathogenic MSH2 P43246 E768C 768 E C 0.758 Pathogenic MSH2 P43246 E768D 768 E D 0.402 Neutral MSH2 P43246 E768F 768 E F 0.962 Pathogenic MSH2 P43246 E768G 768 E G 0.27 Neutral MSH2 P43246 E768H 768 E H 0.726 Pathogenic MSH2 P43246 E768I 768 E I 0.98 Pathogenic MSH2 P43246 E768K 768 E K 0.752 Pathogenic MSH2 P43246 E768L 768 E L 0.972 Pathogenic MSH2 P43246 E768M 768 E M 0.904 Pathogenic MSH2 P43246 E768N 768 E N 0.778 Pathogenic MSH2 P43246 E768P 768 E P 0.938 Pathogenic MSH2 P43246 E768Q 768 E Q 0.366 Neutral MSH2 P43246 E768R 768 E R 0.566 Pathogenic MSH2 P43246 E768S 768 E S 0.894 Pathogenic MSH2 P43246 E768T 768 E T 0.848 Pathogenic MSH2 P43246 E768V 768 E V 0.92 Pathogenic MSH2 P43246 E768W 768 E W 0.98 Pathogenic MSH2 P43246 E768Y 768 E Y 0.96 Pathogenic MSH2 P43246 Y769A 769 Y A 0.378 Neutral MSH2 P43246 Y769C 769 Y C 0.604 Pathogenic MSH2 P43246 Y769D 769 Y D 0.448 Neutral MSH2 P43246 Y769E 769 Y E 0.164 Neutral MSH2 P43246 Y769F 769 Y F 0.156 Neutral MSH2 P43246 Y769G 769 Y G 0.436 Neutral MSH2 P43246 Y769H 769 Y H 0.166 Neutral MSH2 P43246 Y769I 769 Y I 0.724 Pathogenic MSH2 P43246 Y769K 769 Y K 0.784 Pathogenic MSH2 P43246 Y769L 769 Y L 0.612 Pathogenic MSH2 P43246 Y769M 769 Y M 0.614 Pathogenic MSH2 P43246 Y769N 769 Y N 0.358 Neutral MSH2 P43246 Y769P 769 Y P 0.734 Pathogenic MSH2 P43246 Y769Q 769 Y Q 0.308 Neutral MSH2 P43246 Y769R 769 Y R 0.71 Pathogenic MSH2 P43246 Y769S 769 Y S 0.258 Neutral MSH2 P43246 Y769T 769 Y T 0.596 Pathogenic MSH2 P43246 Y769V 769 Y V 0.734 Pathogenic MSH2 P43246 Y769W 769 Y W 0.258 Neutral MSH2 P43246 S77A 77 S A 0.374 Neutral MSH2 P43246 S77C 77 S C 0.212 Neutral MSH2 P43246 S77D 77 S D 0.772 Pathogenic MSH2 P43246 S77E 77 S E 0.892 Pathogenic MSH2 P43246 S77F 77 S F 0.972 Pathogenic MSH2 P43246 S77G 77 S G 0.154 Neutral MSH2 P43246 S77H 77 S H 0.916 Pathogenic MSH2 P43246 S77I 77 S I 0.604 Pathogenic MSH2 P43246 S77K 77 S K 0.88 Pathogenic MSH2 P43246 S77L 77 S L 0.436 Neutral MSH2 P43246 S77M 77 S M 0.992 Pathogenic MSH2 P43246 S77N 77 S N 0.726 Pathogenic MSH2 P43246 S77P 77 S P 0.884 Pathogenic MSH2 P43246 S77Q 77 S Q 0.582 Pathogenic MSH2 P43246 S77R 77 S R 0.924 Pathogenic MSH2 P43246 S77T 77 S T 0.346 Neutral MSH2 P43246 S77V 77 S V 0.422 Neutral MSH2 P43246 S77W 77 S W 0.95 Pathogenic MSH2 P43246 S77Y 77 S Y 0.83 Pathogenic MSH2 P43246 I770A 770 I A 0.622 Pathogenic MSH2 P43246 I770C 770 I C 0.698 Pathogenic MSH2 P43246 I770D 770 I D 0.762 Pathogenic MSH2 P43246 I770E 770 I E 0.762 Pathogenic MSH2 P43246 I770F 770 I F 0.782 Pathogenic MSH2 P43246 I770G 770 I G 0.844 Pathogenic MSH2 P43246 I770H 770 I H 0.882 Pathogenic MSH2 P43246 I770K 770 I K 0.812 Pathogenic MSH2 P43246 I770L 770 I L 0.056 Neutral MSH2 P43246 I770M 770 I M 0.344 Neutral MSH2 P43246 I770N 770 I N 0.784 Pathogenic MSH2 P43246 I770P 770 I P 0.892 Pathogenic MSH2 P43246 I770Q 770 I Q 0.792 Pathogenic MSH2 P43246 I770R 770 I R 0.874 Pathogenic MSH2 P43246 I770S 770 I S 0.66 Pathogenic MSH2 P43246 I770T 770 I T 0.26 Neutral MSH2 P43246 I770V 770 I V 0.092 Neutral MSH2 P43246 I770W 770 I W 0.858 Pathogenic MSH2 P43246 I770Y 770 I Y 0.834 Pathogenic MSH2 P43246 A771C 771 A C 0.444 Neutral MSH2 P43246 A771D 771 A D 0.956 Pathogenic MSH2 P43246 A771E 771 A E 0.984 Pathogenic MSH2 P43246 A771F 771 A F 0.998 Pathogenic MSH2 P43246 A771G 771 A G 0.168 Neutral MSH2 P43246 A771H 771 A H 0.942 Pathogenic MSH2 P43246 A771I 771 A I 0.73 Pathogenic MSH2 P43246 A771K 771 A K 0.976 Pathogenic MSH2 P43246 A771L 771 A L 1 Pathogenic MSH2 P43246 A771M 771 A M 0.73 Pathogenic MSH2 P43246 A771N 771 A N 0.878 Pathogenic MSH2 P43246 A771P 771 A P 0.976 Pathogenic MSH2 P43246 A771Q 771 A Q 0.904 Pathogenic MSH2 P43246 A771R 771 A R 0.982 Pathogenic MSH2 P43246 A771S 771 A S 0.132 Neutral MSH2 P43246 A771T 771 A T 0.288 Neutral MSH2 P43246 A771V 771 A V 0.44 Neutral MSH2 P43246 A771W 771 A W 0.996 Pathogenic MSH2 P43246 A771Y 771 A Y 0.966 Pathogenic MSH2 P43246 T772A 772 T A 0.052 Neutral MSH2 P43246 T772C 772 T C 0.504 Pathogenic MSH2 P43246 T772D 772 T D 0.388 Neutral MSH2 P43246 T772E 772 T E 0.142 Neutral MSH2 P43246 T772F 772 T F 0.754 Pathogenic MSH2 P43246 T772G 772 T G 0.148 Neutral MSH2 P43246 T772H 772 T H 0.466 Neutral MSH2 P43246 T772I 772 T I 0.45 Neutral MSH2 P43246 T772K 772 T K 0.088 Neutral MSH2 P43246 T772L 772 T L 0.092 Neutral MSH2 P43246 T772M 772 T M 0.702 Pathogenic MSH2 P43246 T772N 772 T N 0.014 Neutral MSH2 P43246 T772P 772 T P 0.642 Pathogenic MSH2 P43246 T772Q 772 T Q 0.026 Neutral MSH2 P43246 T772R 772 T R 0.482 Neutral MSH2 P43246 T772S 772 T S 0.004 Neutral MSH2 P43246 T772V 772 T V 0.066 Neutral MSH2 P43246 T772W 772 T W 0.942 Pathogenic MSH2 P43246 T772Y 772 T Y 0.938 Pathogenic MSH2 P43246 K773A 773 K A 0.158 Neutral MSH2 P43246 K773C 773 K C 0.21 Neutral MSH2 P43246 K773D 773 K D 0.02 Neutral MSH2 P43246 K773E 773 K E 0.02 Neutral MSH2 P43246 K773F 773 K F 0.86 Pathogenic MSH2 P43246 K773G 773 K G 0.288 Neutral MSH2 P43246 K773H 773 K H 0.02 Neutral MSH2 P43246 K773I 773 K I 0.902 Pathogenic MSH2 P43246 K773L 773 K L 0.866 Pathogenic MSH2 P43246 K773M 773 K M 0.658 Pathogenic MSH2 P43246 K773N 773 K N 0.028 Neutral MSH2 P43246 K773P 773 K P 0.834 Pathogenic MSH2 P43246 K773Q 773 K Q 0.03 Neutral MSH2 P43246 K773R 773 K R 0.038 Neutral MSH2 P43246 K773S 773 K S 0.39 Neutral MSH2 P43246 K773T 773 K T 0.03 Neutral MSH2 P43246 K773V 773 K V 0.098 Neutral MSH2 P43246 K773W 773 K W 0.972 Pathogenic MSH2 P43246 K773Y 773 K Y 0.932 Pathogenic MSH2 P43246 I774A 774 I A 0.298 Neutral MSH2 P43246 I774C 774 I C 0.386 Neutral MSH2 P43246 I774D 774 I D 0.754 Pathogenic MSH2 P43246 I774E 774 I E 0.754 Pathogenic MSH2 P43246 I774F 774 I F 0.87 Pathogenic MSH2 P43246 I774G 774 I G 0.836 Pathogenic MSH2 P43246 I774H 774 I H 0.898 Pathogenic MSH2 P43246 I774K 774 I K 0.498 Neutral MSH2 P43246 I774L 774 I L 0.068 Neutral MSH2 P43246 I774M 774 I M 0.346 Neutral MSH2 P43246 I774N 774 I N 0.776 Pathogenic MSH2 P43246 I774P 774 I P 0.93 Pathogenic MSH2 P43246 I774Q 774 I Q 0.784 Pathogenic MSH2 P43246 I774R 774 I R 0.862 Pathogenic MSH2 P43246 I774S 774 I S 0.224 Neutral MSH2 P43246 I774T 774 I T 0.058 Neutral MSH2 P43246 I774V 774 I V 0.114 Neutral MSH2 P43246 I774W 774 I W 0.928 Pathogenic MSH2 P43246 I774Y 774 I Y 0.902 Pathogenic MSH2 P43246 G775A 775 G A 0.468 Neutral MSH2 P43246 G775C 775 G C 0.538 Pathogenic MSH2 P43246 G775D 775 G D 0.564 Pathogenic MSH2 P43246 G775E 775 G E 0.82 Pathogenic MSH2 P43246 G775F 775 G F 0.972 Pathogenic MSH2 P43246 G775H 775 G H 0.608 Pathogenic MSH2 P43246 G775I 775 G I 0.958 Pathogenic MSH2 P43246 G775K 775 G K 0.604 Pathogenic MSH2 P43246 G775L 775 G L 0.968 Pathogenic MSH2 P43246 G775M 775 G M 0.984 Pathogenic MSH2 P43246 G775N 775 G N 0.494 Neutral MSH2 P43246 G775P 775 G P 0.928 Pathogenic MSH2 P43246 G775Q 775 G Q 0.568 Pathogenic MSH2 P43246 G775R 775 G R 0.616 Pathogenic MSH2 P43246 G775S 775 G S 0.584 Pathogenic MSH2 P43246 G775T 775 G T 0.842 Pathogenic MSH2 P43246 G775V 775 G V 0.974 Pathogenic MSH2 P43246 G775W 775 G W 0.956 Pathogenic MSH2 P43246 G775Y 775 G Y 0.944 Pathogenic MSH2 P43246 A776C 776 A C 0.406 Neutral MSH2 P43246 A776D 776 A D 0.954 Pathogenic MSH2 P43246 A776E 776 A E 0.976 Pathogenic MSH2 P43246 A776F 776 A F 0.994 Pathogenic MSH2 P43246 A776G 776 A G 0.12 Neutral MSH2 P43246 A776H 776 A H 0.942 Pathogenic MSH2 P43246 A776I 776 A I 0.96 Pathogenic MSH2 P43246 A776K 776 A K 0.972 Pathogenic MSH2 P43246 A776L 776 A L 1 Pathogenic MSH2 P43246 A776M 776 A M 0.908 Pathogenic MSH2 P43246 A776N 776 A N 0.876 Pathogenic MSH2 P43246 A776P 776 A P 0.602 Pathogenic MSH2 P43246 A776Q 776 A Q 0.9 Pathogenic MSH2 P43246 A776R 776 A R 0.982 Pathogenic MSH2 P43246 A776S 776 A S 0.124 Neutral MSH2 P43246 A776T 776 A T 0.286 Neutral MSH2 P43246 A776V 776 A V 0.926 Pathogenic MSH2 P43246 A776W 776 A W 0.996 Pathogenic MSH2 P43246 A776Y 776 A Y 0.966 Pathogenic MSH2 P43246 F777A 777 F A 0.166 Neutral MSH2 P43246 F777C 777 F C 0.256 Neutral MSH2 P43246 F777D 777 F D 0.774 Pathogenic MSH2 P43246 F777E 777 F E 0.84 Pathogenic MSH2 P43246 F777G 777 F G 0.47 Neutral MSH2 P43246 F777H 777 F H 0.698 Pathogenic MSH2 P43246 F777I 777 F I 0.608 Pathogenic MSH2 P43246 F777K 777 F K 0.178 Neutral MSH2 P43246 F777L 777 F L 0.17 Neutral MSH2 P43246 F777M 777 F M 0.722 Pathogenic MSH2 P43246 F777N 777 F N 0.69 Pathogenic MSH2 P43246 F777P 777 F P 0.214 Neutral MSH2 P43246 F777Q 777 F Q 0.71 Pathogenic MSH2 P43246 F777R 777 F R 0.904 Pathogenic MSH2 P43246 F777S 777 F S 0.182 Neutral MSH2 P43246 F777T 777 F T 0.592 Pathogenic MSH2 P43246 F777V 777 F V 0.858 Pathogenic MSH2 P43246 F777W 777 F W 0.944 Pathogenic MSH2 P43246 F777Y 777 F Y 0.274 Neutral MSH2 P43246 C778A 778 C A 0.098 Neutral MSH2 P43246 C778D 778 C D 0.856 Pathogenic MSH2 P43246 C778E 778 C E 0.838 Pathogenic MSH2 P43246 C778F 778 C F 0.982 Pathogenic MSH2 P43246 C778G 778 C G 0.146 Neutral MSH2 P43246 C778H 778 C H 0.864 Pathogenic MSH2 P43246 C778I 778 C I 0.926 Pathogenic MSH2 P43246 C778K 778 C K 0.816 Pathogenic MSH2 P43246 C778L 778 C L 0.942 Pathogenic MSH2 P43246 C778M 778 C M 0.752 Pathogenic MSH2 P43246 C778N 778 C N 0.678 Pathogenic MSH2 P43246 C778P 778 C P 0.96 Pathogenic MSH2 P43246 C778Q 778 C Q 0.718 Pathogenic MSH2 P43246 C778R 778 C R 0.98 Pathogenic MSH2 P43246 C778S 778 C S 0.106 Neutral MSH2 P43246 C778T 778 C T 0.126 Neutral MSH2 P43246 C778V 778 C V 0.456 Neutral MSH2 P43246 C778W 778 C W 0.982 Pathogenic MSH2 P43246 C778Y 778 C Y 0.978 Pathogenic MSH2 P43246 M779A 779 M A 0.226 Neutral MSH2 P43246 M779C 779 M C 0.106 Neutral MSH2 P43246 M779D 779 M D 0.862 Pathogenic MSH2 P43246 M779E 779 M E 0.784 Pathogenic MSH2 P43246 M779F 779 M F 0.402 Neutral MSH2 P43246 M779G 779 M G 0.522 Pathogenic MSH2 P43246 M779H 779 M H 0.888 Pathogenic MSH2 P43246 M779I 779 M I 0.502 Pathogenic MSH2 P43246 M779K 779 M K 0.944 Pathogenic MSH2 P43246 M779L 779 M L 0.208 Neutral MSH2 P43246 M779N 779 M N 0.896 Pathogenic MSH2 P43246 M779P 779 M P 0.93 Pathogenic MSH2 P43246 M779Q 779 M Q 0.74 Pathogenic MSH2 P43246 M779R 779 M R 0.958 Pathogenic MSH2 P43246 M779S 779 M S 0.884 Pathogenic MSH2 P43246 M779T 779 M T 0.76 Pathogenic MSH2 P43246 M779V 779 M V 0.176 Neutral MSH2 P43246 M779W 779 M W 0.996 Pathogenic MSH2 P43246 M779Y 779 M Y 0.978 Pathogenic MSH2 P43246 V78A 78 V A 0.038 Neutral MSH2 P43246 V78C 78 V C 0.25 Neutral MSH2 P43246 V78D 78 V D 0.452 Neutral MSH2 P43246 V78E 78 V E 0.53 Pathogenic MSH2 P43246 V78F 78 V F 0.484 Neutral MSH2 P43246 V78G 78 V G 0.63 Pathogenic MSH2 P43246 V78H 78 V H 0.246 Neutral MSH2 P43246 V78I 78 V I 0.084 Neutral MSH2 P43246 V78K 78 V K 0.36 Neutral MSH2 P43246 V78L 78 V L 0.358 Neutral MSH2 P43246 V78M 78 V M 0.5 Pathogenic MSH2 P43246 V78N 78 V N 0.13 Neutral MSH2 P43246 V78P 78 V P 0.862 Pathogenic MSH2 P43246 V78Q 78 V Q 0.724 Pathogenic MSH2 P43246 V78R 78 V R 0.756 Pathogenic MSH2 P43246 V78S 78 V S 0.058 Neutral MSH2 P43246 V78T 78 V T 0.088 Neutral MSH2 P43246 V78W 78 V W 0.842 Pathogenic MSH2 P43246 V78Y 78 V Y 0.566 Pathogenic MSH2 P43246 F780A 780 F A 0.506 Pathogenic MSH2 P43246 F780C 780 F C 0.734 Pathogenic MSH2 P43246 F780D 780 F D 0.826 Pathogenic MSH2 P43246 F780E 780 F E 0.878 Pathogenic MSH2 P43246 F780G 780 F G 0.508 Pathogenic MSH2 P43246 F780H 780 F H 0.786 Pathogenic MSH2 P43246 F780I 780 F I 0.694 Pathogenic MSH2 P43246 F780K 780 F K 0.858 Pathogenic MSH2 P43246 F780L 780 F L 0.708 Pathogenic MSH2 P43246 F780M 780 F M 0.8 Pathogenic MSH2 P43246 F780N 780 F N 0.774 Pathogenic MSH2 P43246 F780P 780 F P 0.954 Pathogenic MSH2 P43246 F780Q 780 F Q 0.794 Pathogenic MSH2 P43246 F780R 780 F R 0.922 Pathogenic MSH2 P43246 F780S 780 F S 0.882 Pathogenic MSH2 P43246 F780T 780 F T 0.61 Pathogenic MSH2 P43246 F780V 780 F V 0.766 Pathogenic MSH2 P43246 F780W 780 F W 0.874 Pathogenic MSH2 P43246 F780Y 780 F Y 0.588 Pathogenic MSH2 P43246 A781C 781 A C 0.87 Pathogenic MSH2 P43246 A781D 781 A D 0.93 Pathogenic MSH2 P43246 A781E 781 A E 0.884 Pathogenic MSH2 P43246 A781F 781 A F 0.97 Pathogenic MSH2 P43246 A781G 781 A G 0.774 Pathogenic MSH2 P43246 A781H 781 A H 0.872 Pathogenic MSH2 P43246 A781I 781 A I 0.962 Pathogenic MSH2 P43246 A781K 781 A K 0.94 Pathogenic MSH2 P43246 A781L 781 A L 0.984 Pathogenic MSH2 P43246 A781M 781 A M 0.86 Pathogenic MSH2 P43246 A781N 781 A N 0.864 Pathogenic MSH2 P43246 A781P 781 A P 0.966 Pathogenic MSH2 P43246 A781Q 781 A Q 0.824 Pathogenic MSH2 P43246 A781R 781 A R 0.962 Pathogenic MSH2 P43246 A781S 781 A S 0.454 Neutral MSH2 P43246 A781T 781 A T 0.744 Pathogenic MSH2 P43246 A781V 781 A V 0.914 Pathogenic MSH2 P43246 A781W 781 A W 0.98 Pathogenic MSH2 P43246 A781Y 781 A Y 0.966 Pathogenic MSH2 P43246 T782A 782 T A 0.71 Pathogenic MSH2 P43246 T782C 782 T C 0.936 Pathogenic MSH2 P43246 T782D 782 T D 0.95 Pathogenic MSH2 P43246 T782E 782 T E 0.948 Pathogenic MSH2 P43246 T782F 782 T F 0.948 Pathogenic MSH2 P43246 T782G 782 T G 0.738 Pathogenic MSH2 P43246 T782H 782 T H 0.924 Pathogenic MSH2 P43246 T782I 782 T I 0.946 Pathogenic MSH2 P43246 T782K 782 T K 0.936 Pathogenic MSH2 P43246 T782L 782 T L 0.946 Pathogenic MSH2 P43246 T782M 782 T M 0.982 Pathogenic MSH2 P43246 T782N 782 T N 0.892 Pathogenic MSH2 P43246 T782P 782 T P 0.962 Pathogenic MSH2 P43246 T782Q 782 T Q 0.89 Pathogenic MSH2 P43246 T782R 782 T R 0.992 Pathogenic MSH2 P43246 T782S 782 T S 0.374 Neutral MSH2 P43246 T782V 782 T V 0.842 Pathogenic MSH2 P43246 T782W 782 T W 0.974 Pathogenic MSH2 P43246 T782Y 782 T Y 0.974 Pathogenic MSH2 P43246 H783A 783 H A 0.726 Pathogenic MSH2 P43246 H783C 783 H C 0.708 Pathogenic MSH2 P43246 H783D 783 H D 0.664 Pathogenic MSH2 P43246 H783E 783 H E 0.836 Pathogenic MSH2 P43246 H783F 783 H F 0.908 Pathogenic MSH2 P43246 H783G 783 H G 0.512 Pathogenic MSH2 P43246 H783I 783 H I 0.906 Pathogenic MSH2 P43246 H783K 783 H K 0.696 Pathogenic MSH2 P43246 H783L 783 H L 0.758 Pathogenic MSH2 P43246 H783M 783 H M 0.666 Pathogenic MSH2 P43246 H783N 783 H N 0.65 Pathogenic MSH2 P43246 H783P 783 H P 0.99 Pathogenic MSH2 P43246 H783Q 783 H Q 0.842 Pathogenic MSH2 P43246 H783R 783 H R 0.918 Pathogenic MSH2 P43246 H783S 783 H S 0.672 Pathogenic MSH2 P43246 H783T 783 H T 0.592 Pathogenic MSH2 P43246 H783V 783 H V 0.724 Pathogenic MSH2 P43246 H783W 783 H W 0.966 Pathogenic MSH2 P43246 H783Y 783 H Y 0.916 Pathogenic MSH2 P43246 F784A 784 F A 0.506 Pathogenic MSH2 P43246 F784C 784 F C 0.734 Pathogenic MSH2 P43246 F784D 784 F D 0.826 Pathogenic MSH2 P43246 F784E 784 F E 0.878 Pathogenic MSH2 P43246 F784G 784 F G 0.508 Pathogenic MSH2 P43246 F784H 784 F H 0.786 Pathogenic MSH2 P43246 F784I 784 F I 0.694 Pathogenic MSH2 P43246 F784K 784 F K 0.858 Pathogenic MSH2 P43246 F784L 784 F L 0.708 Pathogenic MSH2 P43246 F784M 784 F M 0.8 Pathogenic MSH2 P43246 F784N 784 F N 0.774 Pathogenic MSH2 P43246 F784P 784 F P 0.954 Pathogenic MSH2 P43246 F784Q 784 F Q 0.794 Pathogenic MSH2 P43246 F784R 784 F R 0.922 Pathogenic MSH2 P43246 F784S 784 F S 0.882 Pathogenic MSH2 P43246 F784T 784 F T 0.61 Pathogenic MSH2 P43246 F784V 784 F V 0.766 Pathogenic MSH2 P43246 F784W 784 F W 0.874 Pathogenic MSH2 P43246 F784Y 784 F Y 0.58 Pathogenic MSH2 P43246 H785A 785 H A 0.722 Pathogenic MSH2 P43246 H785C 785 H C 0.702 Pathogenic MSH2 P43246 H785D 785 H D 0.66 Pathogenic MSH2 P43246 H785E 785 H E 0.832 Pathogenic MSH2 P43246 H785F 785 H F 0.908 Pathogenic MSH2 P43246 H785G 785 H G 0.508 Pathogenic MSH2 P43246 H785I 785 H I 0.9 Pathogenic MSH2 P43246 H785K 785 H K 0.696 Pathogenic MSH2 P43246 H785L 785 H L 0.756 Pathogenic MSH2 P43246 H785M 785 H M 0.666 Pathogenic MSH2 P43246 H785N 785 H N 0.646 Pathogenic MSH2 P43246 H785P 785 H P 0.982 Pathogenic MSH2 P43246 H785Q 785 H Q 0.398 Neutral MSH2 P43246 H785R 785 H R 0.914 Pathogenic MSH2 P43246 H785S 785 H S 0.67 Pathogenic MSH2 P43246 H785T 785 H T 0.588 Pathogenic MSH2 P43246 H785V 785 H V 0.718 Pathogenic MSH2 P43246 H785W 785 H W 0.966 Pathogenic MSH2 P43246 H785Y 785 H Y 0.88 Pathogenic MSH2 P43246 E786A 786 E A 0.812 Pathogenic MSH2 P43246 E786C 786 E C 0.77 Pathogenic MSH2 P43246 E786D 786 E D 0.894 Pathogenic MSH2 P43246 E786F 786 E F 0.962 Pathogenic MSH2 P43246 E786G 786 E G 0.342 Neutral MSH2 P43246 E786H 786 E H 0.76 Pathogenic MSH2 P43246 E786I 786 E I 0.98 Pathogenic MSH2 P43246 E786K 786 E K 0.928 Pathogenic MSH2 P43246 E786L 786 E L 0.976 Pathogenic MSH2 P43246 E786M 786 E M 0.92 Pathogenic MSH2 P43246 E786N 786 E N 0.8 Pathogenic MSH2 P43246 E786P 786 E P 0.944 Pathogenic MSH2 P43246 E786Q 786 E Q 0.87 Pathogenic MSH2 P43246 E786R 786 E R 0.936 Pathogenic MSH2 P43246 E786S 786 E S 0.916 Pathogenic MSH2 P43246 E786T 786 E T 0.86 Pathogenic MSH2 P43246 E786V 786 E V 0.926 Pathogenic MSH2 P43246 E786W 786 E W 0.982 Pathogenic MSH2 P43246 E786Y 786 E Y 0.96 Pathogenic MSH2 P43246 L787A 787 L A 0.714 Pathogenic MSH2 P43246 L787C 787 L C 0.816 Pathogenic MSH2 P43246 L787D 787 L D 0.9 Pathogenic MSH2 P43246 L787E 787 L E 0.882 Pathogenic MSH2 P43246 L787F 787 L F 0.862 Pathogenic MSH2 P43246 L787G 787 L G 0.87 Pathogenic MSH2 P43246 L787H 787 L H 0.906 Pathogenic MSH2 P43246 L787I 787 L I 0.27 Neutral MSH2 P43246 L787K 787 L K 0.712 Pathogenic MSH2 P43246 L787M 787 L M 0.216 Neutral MSH2 P43246 L787N 787 L N 0.81 Pathogenic MSH2 P43246 L787P 787 L P 0.978 Pathogenic MSH2 P43246 L787Q 787 L Q 0.764 Pathogenic MSH2 P43246 L787R 787 L R 0.982 Pathogenic MSH2 P43246 L787S 787 L S 0.7 Pathogenic MSH2 P43246 L787T 787 L T 0.616 Pathogenic MSH2 P43246 L787V 787 L V 0.398 Neutral MSH2 P43246 L787W 787 L W 0.868 Pathogenic MSH2 P43246 L787Y 787 L Y 0.882 Pathogenic MSH2 P43246 T788A 788 T A 0.72 Pathogenic MSH2 P43246 T788C 788 T C 0.942 Pathogenic MSH2 P43246 T788D 788 T D 0.956 Pathogenic MSH2 P43246 T788E 788 T E 0.952 Pathogenic MSH2 P43246 T788F 788 T F 0.95 Pathogenic MSH2 P43246 T788G 788 T G 0.758 Pathogenic MSH2 P43246 T788H 788 T H 0.926 Pathogenic MSH2 P43246 T788I 788 T I 0.952 Pathogenic MSH2 P43246 T788K 788 T K 0.94 Pathogenic MSH2 P43246 T788L 788 T L 0.952 Pathogenic MSH2 P43246 T788M 788 T M 0.984 Pathogenic MSH2 P43246 T788N 788 T N 0.908 Pathogenic MSH2 P43246 T788P 788 T P 0.968 Pathogenic MSH2 P43246 T788Q 788 T Q 0.896 Pathogenic MSH2 P43246 T788R 788 T R 0.994 Pathogenic MSH2 P43246 T788S 788 T S 0.504 Pathogenic MSH2 P43246 T788V 788 T V 0.762 Pathogenic MSH2 P43246 T788W 788 T W 0.978 Pathogenic MSH2 P43246 T788Y 788 T Y 0.978 Pathogenic MSH2 P43246 A789C 789 A C 0.95 Pathogenic MSH2 P43246 A789D 789 A D 0.714 Pathogenic MSH2 P43246 A789E 789 A E 0.6 Pathogenic MSH2 P43246 A789F 789 A F 0.99 Pathogenic MSH2 P43246 A789G 789 A G 0.35 Neutral MSH2 P43246 A789H 789 A H 0.924 Pathogenic MSH2 P43246 A789I 789 A I 0.756 Pathogenic MSH2 P43246 A789K 789 A K 0.65 Pathogenic MSH2 P43246 A789L 789 A L 0.994 Pathogenic MSH2 P43246 A789M 789 A M 0.89 Pathogenic MSH2 P43246 A789N 789 A N 0.528 Pathogenic MSH2 P43246 A789P 789 A P 0.966 Pathogenic MSH2 P43246 A789Q 789 A Q 0.896 Pathogenic MSH2 P43246 A789R 789 A R 0.616 Pathogenic MSH2 P43246 A789S 789 A S 0.11 Neutral MSH2 P43246 A789T 789 A T 0.188 Neutral MSH2 P43246 A789V 789 A V 0.594 Pathogenic MSH2 P43246 A789W 789 A W 0.99 Pathogenic MSH2 P43246 A789Y 789 A Y 0.956 Pathogenic MSH2 P43246 V79A 79 V A 0.044 Neutral MSH2 P43246 V79C 79 V C 0.412 Neutral MSH2 P43246 V79D 79 V D 0.6 Pathogenic MSH2 P43246 V79E 79 V E 0.702 Pathogenic MSH2 P43246 V79F 79 V F 0.608 Pathogenic MSH2 P43246 V79G 79 V G 0.614 Pathogenic MSH2 P43246 V79H 79 V H 0.56 Pathogenic MSH2 P43246 V79I 79 V I 0.08 Neutral MSH2 P43246 V79K 79 V K 0.768 Pathogenic MSH2 P43246 V79L 79 V L 0.07 Neutral MSH2 P43246 V79M 79 V M 0.082 Neutral MSH2 P43246 V79N 79 V N 0.47 Neutral MSH2 P43246 V79P 79 V P 0.822 Pathogenic MSH2 P43246 V79Q 79 V Q 0.722 Pathogenic MSH2 P43246 V79R 79 V R 0.824 Pathogenic MSH2 P43246 V79S 79 V S 0.26 Neutral MSH2 P43246 V79T 79 V T 0.174 Neutral MSH2 P43246 V79W 79 V W 0.84 Pathogenic MSH2 P43246 V79Y 79 V Y 0.832 Pathogenic MSH2 P43246 L790A 790 L A 0.706 Pathogenic MSH2 P43246 L790C 790 L C 0.818 Pathogenic MSH2 P43246 L790D 790 L D 0.902 Pathogenic MSH2 P43246 L790E 790 L E 0.888 Pathogenic MSH2 P43246 L790F 790 L F 0.876 Pathogenic MSH2 P43246 L790G 790 L G 0.852 Pathogenic MSH2 P43246 L790H 790 L H 0.904 Pathogenic MSH2 P43246 L790I 790 L I 0.662 Pathogenic MSH2 P43246 L790K 790 L K 0.708 Pathogenic MSH2 P43246 L790M 790 L M 0.362 Neutral MSH2 P43246 L790N 790 L N 0.814 Pathogenic MSH2 P43246 L790P 790 L P 0.98 Pathogenic MSH2 P43246 L790Q 790 L Q 0.772 Pathogenic MSH2 P43246 L790R 790 L R 0.98 Pathogenic MSH2 P43246 L790S 790 L S 0.684 Pathogenic MSH2 P43246 L790T 790 L T 0.61 Pathogenic MSH2 P43246 L790V 790 L V 0.426 Neutral MSH2 P43246 L790W 790 L W 0.88 Pathogenic MSH2 P43246 L790Y 790 L Y 0.888 Pathogenic MSH2 P43246 A791C 791 A C 0.688 Pathogenic MSH2 P43246 A791D 791 A D 0.64 Pathogenic MSH2 P43246 A791E 791 A E 0.598 Pathogenic MSH2 P43246 A791F 791 A F 0.994 Pathogenic MSH2 P43246 A791G 791 A G 0.358 Neutral MSH2 P43246 A791H 791 A H 0.8 Pathogenic MSH2 P43246 A791I 791 A I 0.956 Pathogenic MSH2 P43246 A791K 791 A K 0.746 Pathogenic MSH2 P43246 A791L 791 A L 0.998 Pathogenic MSH2 P43246 A791M 791 A M 0.896 Pathogenic MSH2 P43246 A791N 791 A N 0.562 Pathogenic MSH2 P43246 A791P 791 A P 0.974 Pathogenic MSH2 P43246 A791Q 791 A Q 0.52 Pathogenic MSH2 P43246 A791R 791 A R 0.97 Pathogenic MSH2 P43246 A791S 791 A S 0.122 Neutral MSH2 P43246 A791T 791 A T 0.218 Neutral MSH2 P43246 A791V 791 A V 0.448 Neutral MSH2 P43246 A791W 791 A W 0.994 Pathogenic MSH2 P43246 A791Y 791 A Y 0.962 Pathogenic MSH2 P43246 N792A 792 N A 0.088 Neutral MSH2 P43246 N792C 792 N C 0.608 Pathogenic MSH2 P43246 N792D 792 N D 0.21 Neutral MSH2 P43246 N792E 792 N E 0.038 Neutral MSH2 P43246 N792F 792 N F 0.922 Pathogenic MSH2 P43246 N792G 792 N G 0.086 Neutral MSH2 P43246 N792H 792 N H 0.064 Neutral MSH2 P43246 N792I 792 N I 0.894 Pathogenic MSH2 P43246 N792K 792 N K 0.122 Neutral MSH2 P43246 N792L 792 N L 0.826 Pathogenic MSH2 P43246 N792M 792 N M 0.862 Pathogenic MSH2 P43246 N792P 792 N P 0.774 Pathogenic MSH2 P43246 N792Q 792 N Q 0.03 Neutral MSH2 P43246 N792R 792 N R 0.626 Pathogenic MSH2 P43246 N792S 792 N S 0.038 Neutral MSH2 P43246 N792T 792 N T 0.568 Pathogenic MSH2 P43246 N792V 792 N V 0.934 Pathogenic MSH2 P43246 N792W 792 N W 0.956 Pathogenic MSH2 P43246 N792Y 792 N Y 0.948 Pathogenic MSH2 P43246 Q793A 793 Q A 0.154 Neutral MSH2 P43246 Q793C 793 Q C 0.442 Neutral MSH2 P43246 Q793D 793 Q D 0.054 Neutral MSH2 P43246 Q793E 793 Q E 0.034 Neutral MSH2 P43246 Q793F 793 Q F 0.818 Pathogenic MSH2 P43246 Q793G 793 Q G 0.34 Neutral MSH2 P43246 Q793H 793 Q H 0.24 Neutral MSH2 P43246 Q793I 793 Q I 0.442 Neutral MSH2 P43246 Q793K 793 Q K 0.066 Neutral MSH2 P43246 Q793L 793 Q L 0.486 Neutral MSH2 P43246 Q793M 793 Q M 0.722 Pathogenic MSH2 P43246 Q793N 793 Q N 0.334 Neutral MSH2 P43246 Q793P 793 Q P 0.838 Pathogenic MSH2 P43246 Q793R 793 Q R 0.074 Neutral MSH2 P43246 Q793S 793 Q S 0.364 Neutral MSH2 P43246 Q793T 793 Q T 0.03 Neutral MSH2 P43246 Q793V 793 Q V 0.1 Neutral MSH2 P43246 Q793W 793 Q W 0.93 Pathogenic MSH2 P43246 Q793Y 793 Q Y 0.684 Pathogenic MSH2 P43246 I794A 794 I A 0.218 Neutral MSH2 P43246 I794C 794 I C 0.124 Neutral MSH2 P43246 I794D 794 I D 0.544 Pathogenic MSH2 P43246 I794E 794 I E 0.526 Pathogenic MSH2 P43246 I794F 794 I F 0.162 Neutral MSH2 P43246 I794G 794 I G 0.552 Pathogenic MSH2 P43246 I794H 794 I H 0.052 Neutral MSH2 P43246 I794K 794 I K 0.3 Neutral MSH2 P43246 I794L 794 I L 0.014 Neutral MSH2 P43246 I794M 794 I M 0.368 Neutral MSH2 P43246 I794N 794 I N 0.16 Neutral MSH2 P43246 I794P 794 I P 0.648 Pathogenic MSH2 P43246 I794Q 794 I Q 0.156 Neutral MSH2 P43246 I794R 794 I R 0.64 Pathogenic MSH2 P43246 I794S 794 I S 0.532 Pathogenic MSH2 P43246 I794T 794 I T 0.45 Neutral MSH2 P43246 I794V 794 I V 0.012 Neutral MSH2 P43246 I794W 794 I W 0.858 Pathogenic MSH2 P43246 I794Y 794 I Y 0.594 Pathogenic MSH2 P43246 P795A 795 P A 0.168 Neutral MSH2 P43246 P795C 795 P C 0.916 Pathogenic MSH2 P43246 P795D 795 P D 0.406 Neutral MSH2 P43246 P795E 795 P E 0.268 Neutral MSH2 P43246 P795F 795 P F 0.998 Pathogenic MSH2 P43246 P795G 795 P G 0.106 Neutral MSH2 P43246 P795H 795 P H 0.99 Pathogenic MSH2 P43246 P795I 795 P I 0.7 Pathogenic MSH2 P43246 P795K 795 P K 0.262 Neutral MSH2 P43246 P795L 795 P L 0.986 Pathogenic MSH2 P43246 P795M 795 P M 0.972 Pathogenic MSH2 P43246 P795N 795 P N 0.18 Neutral MSH2 P43246 P795Q 795 P Q 0.87 Pathogenic MSH2 P43246 P795R 795 P R 0.69 Pathogenic MSH2 P43246 P795S 795 P S 0.082 Neutral MSH2 P43246 P795T 795 P T 0.13 Neutral MSH2 P43246 P795V 795 P V 0.236 Neutral MSH2 P43246 P795W 795 P W 0.946 Pathogenic MSH2 P43246 P795Y 795 P Y 0.944 Pathogenic MSH2 P43246 T796A 796 T A 0.058 Neutral MSH2 P43246 T796C 796 T C 0.376 Neutral MSH2 P43246 T796D 796 T D 0.52 Pathogenic MSH2 P43246 T796E 796 T E 0.522 Pathogenic MSH2 P43246 T796F 796 T F 0.654 Pathogenic MSH2 P43246 T796G 796 T G 0.052 Neutral MSH2 P43246 T796H 796 T H 0.21 Neutral MSH2 P43246 T796I 796 T I 0.464 Neutral MSH2 P43246 T796K 796 T K 0.444 Neutral MSH2 P43246 T796L 796 T L 0.448 Neutral MSH2 P43246 T796M 796 T M 0.544 Pathogenic MSH2 P43246 T796N 796 T N 0.036 Neutral MSH2 P43246 T796P 796 T P 0.638 Pathogenic MSH2 P43246 T796Q 796 T Q 0.044 Neutral MSH2 P43246 T796R 796 T R 0.702 Pathogenic MSH2 P43246 T796S 796 T S 0.028 Neutral MSH2 P43246 T796V 796 T V 0.218 Neutral MSH2 P43246 T796W 796 T W 0.946 Pathogenic MSH2 P43246 T796Y 796 T Y 0.918 Pathogenic MSH2 P43246 V797A 797 V A 0.332 Neutral MSH2 P43246 V797C 797 V C 0.812 Pathogenic MSH2 P43246 V797D 797 V D 0.872 Pathogenic MSH2 P43246 V797E 797 V E 0.966 Pathogenic MSH2 P43246 V797F 797 V F 0.932 Pathogenic MSH2 P43246 V797G 797 V G 0.924 Pathogenic MSH2 P43246 V797H 797 V H 0.916 Pathogenic MSH2 P43246 V797I 797 V I 0.418 Neutral MSH2 P43246 V797K 797 V K 0.984 Pathogenic MSH2 P43246 V797L 797 V L 0.676 Pathogenic MSH2 P43246 V797M 797 V M 0.92 Pathogenic MSH2 P43246 V797N 797 V N 0.928 Pathogenic MSH2 P43246 V797P 797 V P 0.992 Pathogenic MSH2 P43246 V797Q 797 V Q 0.972 Pathogenic MSH2 P43246 V797R 797 V R 0.956 Pathogenic MSH2 P43246 V797S 797 V S 0.814 Pathogenic MSH2 P43246 V797T 797 V T 0.882 Pathogenic MSH2 P43246 V797W 797 V W 0.956 Pathogenic MSH2 P43246 V797Y 797 V Y 0.976 Pathogenic MSH2 P43246 N798A 798 N A 0.084 Neutral MSH2 P43246 N798C 798 N C 0.598 Pathogenic MSH2 P43246 N798D 798 N D 0.33 Neutral MSH2 P43246 N798E 798 N E 0.34 Neutral MSH2 P43246 N798F 798 N F 0.918 Pathogenic MSH2 P43246 N798G 798 N G 0.178 Neutral MSH2 P43246 N798H 798 N H 0.088 Neutral MSH2 P43246 N798I 798 N I 0.868 Pathogenic MSH2 P43246 N798K 798 N K 0.148 Neutral MSH2 P43246 N798L 798 N L 0.858 Pathogenic MSH2 P43246 N798M 798 N M 0.818 Pathogenic MSH2 P43246 N798P 798 N P 0.748 Pathogenic MSH2 P43246 N798Q 798 N Q 0.046 Neutral MSH2 P43246 N798R 798 N R 0.46 Neutral MSH2 P43246 N798S 798 N S 0.05 Neutral MSH2 P43246 N798T 798 N T 0.046 Neutral MSH2 P43246 N798V 798 N V 0.122 Neutral MSH2 P43246 N798W 798 N W 0.954 Pathogenic MSH2 P43246 N798Y 798 N Y 0.822 Pathogenic MSH2 P43246 N799A 799 N A 0.802 Pathogenic MSH2 P43246 N799C 799 N C 0.782 Pathogenic MSH2 P43246 N799D 799 N D 0.748 Pathogenic MSH2 P43246 N799E 799 N E 0.63 Pathogenic MSH2 P43246 N799F 799 N F 0.96 Pathogenic MSH2 P43246 N799G 799 N G 0.738 Pathogenic MSH2 P43246 N799H 799 N H 0.876 Pathogenic MSH2 P43246 N799I 799 N I 0.948 Pathogenic MSH2 P43246 N799K 799 N K 0.94 Pathogenic MSH2 P43246 N799L 799 N L 0.964 Pathogenic MSH2 P43246 N799M 799 N M 0.962 Pathogenic MSH2 P43246 N799P 799 N P 0.874 Pathogenic MSH2 P43246 N799Q 799 N Q 0.816 Pathogenic MSH2 P43246 N799R 799 N R 0.95 Pathogenic MSH2 P43246 N799S 799 N S 0.432 Neutral MSH2 P43246 N799T 799 N T 0.552 Pathogenic MSH2 P43246 N799V 799 N V 0.99 Pathogenic MSH2 P43246 N799W 799 N W 0.974 Pathogenic MSH2 P43246 N799Y 799 N Y 0.97 Pathogenic MSH2 P43246 T8A 8 T A 0.08 Neutral MSH2 P43246 T8C 8 T C 0.008 Neutral MSH2 P43246 T8D 8 T D 0.022 Neutral MSH2 P43246 T8E 8 T E 0.024 Neutral MSH2 P43246 T8F 8 T F 0.214 Neutral MSH2 P43246 T8G 8 T G 0.058 Neutral MSH2 P43246 T8H 8 T H 0.084 Neutral MSH2 P43246 T8I 8 T I 0.096 Neutral MSH2 P43246 T8K 8 T K 0.004 Neutral MSH2 P43246 T8L 8 T L 0.016 Neutral MSH2 P43246 T8M 8 T M 0.044 Neutral 1 MSH2 P43246 T8N 8 T N 0 Neutral MSH2 P43246 T8P 8 T P 0.084 Neutral MSH2 P43246 T8Q 8 T Q 0 Neutral MSH2 P43246 T8R 8 T R 0.156 Neutral MSH2 P43246 T8S 8 T S 0.032 Neutral MSH2 P43246 T8V 8 T V 0.096 Neutral MSH2 P43246 T8W 8 T W 0.466 Neutral MSH2 P43246 T8Y 8 T Y 0.424 Neutral MSH2 P43246 L80A 80 L A 0.258 Neutral MSH2 P43246 L80C 80 L C 0.324 Neutral MSH2 P43246 L80D 80 L D 0.608 Pathogenic MSH2 P43246 L80E 80 L E 0.562 Pathogenic MSH2 P43246 L80F 80 L F 0.77 Pathogenic MSH2 P43246 L80G 80 L G 0.32 Neutral MSH2 P43246 L80H 80 L H 0.346 Neutral MSH2 P43246 L80I 80 L I 0.496 Neutral MSH2 P43246 L80K 80 L K 0.042 Neutral MSH2 P43246 L80M 80 L M 0.44 Neutral MSH2 P43246 L80N 80 L N 0.082 Neutral MSH2 P43246 L80P 80 L P 0.914 Pathogenic MSH2 P43246 L80Q 80 L Q 0.3 Neutral MSH2 P43246 L80R 80 L R 0.534 Pathogenic MSH2 P43246 L80S 80 L S 0.088 Neutral MSH2 P43246 L80T 80 L T 0.034 Neutral MSH2 P43246 L80V 80 L V 0.446 Neutral MSH2 P43246 L80W 80 L W 0.866 Pathogenic MSH2 P43246 L80Y 80 L Y 0.862 Pathogenic MSH2 P43246 L800A 800 L A 0.188 Neutral MSH2 P43246 L800C 800 L C 0.102 Neutral MSH2 P43246 L800D 800 L D 0.91 Pathogenic MSH2 P43246 L800E 800 L E 0.5 Pathogenic MSH2 P43246 L800F 800 L F 0.464 Neutral MSH2 P43246 L800G 800 L G 0.806 Pathogenic MSH2 P43246 L800H 800 L H 0.348 Neutral MSH2 P43246 L800I 800 L I 0.82 Pathogenic MSH2 P43246 L800K 800 L K 0.182 Neutral MSH2 P43246 L800M 800 L M 0.17 Neutral MSH2 P43246 L800N 800 L N 0.78 Pathogenic MSH2 P43246 L800P 800 L P 0.994 Pathogenic MSH2 P43246 L800Q 800 L Q 0.13 Neutral MSH2 P43246 L800R 800 L R 0.562 Pathogenic MSH2 P43246 L800S 800 L S 0.126 Neutral MSH2 P43246 L800T 800 L T 0.594 Pathogenic MSH2 P43246 L800V 800 L V 0.316 Neutral MSH2 P43246 L800W 800 L W 0.928 Pathogenic MSH2 P43246 L800Y 800 L Y 0.63 Pathogenic MSH2 P43246 H801A 801 H A 0.724 Pathogenic MSH2 P43246 H801C 801 H C 0.704 Pathogenic MSH2 P43246 H801D 801 H D 0.66 Pathogenic MSH2 P43246 H801E 801 H E 0.832 Pathogenic MSH2 P43246 H801F 801 H F 0.908 Pathogenic MSH2 P43246 H801G 801 H G 0.51 Pathogenic MSH2 P43246 H801I 801 H I 0.906 Pathogenic MSH2 P43246 H801K 801 H K 0.696 Pathogenic MSH2 P43246 H801L 801 H L 0.758 Pathogenic MSH2 P43246 H801M 801 H M 0.666 Pathogenic MSH2 P43246 H801N 801 H N 0.406 Neutral MSH2 P43246 H801P 801 H P 0.99 Pathogenic MSH2 P43246 H801Q 801 H Q 0.522 Pathogenic MSH2 P43246 H801R 801 H R 0.914 Pathogenic MSH2 P43246 H801S 801 H S 0.672 Pathogenic MSH2 P43246 H801T 801 H T 0.59 Pathogenic MSH2 P43246 H801V 801 H V 0.724 Pathogenic MSH2 P43246 H801W 801 H W 0.966 Pathogenic MSH2 P43246 H801Y 801 H Y 0.916 Pathogenic MSH2 P43246 V802A 802 V A 0.4 Neutral MSH2 P43246 V802C 802 V C 0.812 Pathogenic MSH2 P43246 V802D 802 V D 0.87 Pathogenic MSH2 P43246 V802E 802 V E 0.964 Pathogenic MSH2 P43246 V802F 802 V F 0.932 Pathogenic MSH2 P43246 V802G 802 V G 0.922 Pathogenic MSH2 P43246 V802H 802 V H 0.914 Pathogenic MSH2 P43246 V802I 802 V I 0.63 Pathogenic MSH2 P43246 V802K 802 V K 0.984 Pathogenic MSH2 P43246 V802L 802 V L 0.952 Pathogenic MSH2 P43246 V802M 802 V M 0.468 Neutral MSH2 P43246 V802N 802 V N 0.926 Pathogenic MSH2 P43246 V802P 802 V P 0.992 Pathogenic MSH2 P43246 V802Q 802 V Q 0.97 Pathogenic MSH2 P43246 V802R 802 V R 0.954 Pathogenic MSH2 P43246 V802S 802 V S 0.814 Pathogenic MSH2 P43246 V802T 802 V T 0.882 Pathogenic MSH2 P43246 V802W 802 V W 0.956 Pathogenic MSH2 P43246 V802Y 802 V Y 0.976 Pathogenic MSH2 P43246 T803A 803 T A 0.052 Neutral MSH2 P43246 T803C 803 T C 0.588 Pathogenic MSH2 P43246 T803D 803 T D 0.166 Neutral MSH2 P43246 T803E 803 T E 0.184 Neutral MSH2 P43246 T803F 803 T F 0.782 Pathogenic MSH2 P43246 T803G 803 T G 0.062 Neutral MSH2 P43246 T803H 803 T H 0.648 Pathogenic MSH2 P43246 T803I 803 T I 0.214 Neutral MSH2 P43246 T803K 803 T K 0.428 Neutral MSH2 P43246 T803L 803 T L 0.424 Neutral MSH2 P43246 T803M 803 T M 0.732 Pathogenic MSH2 P43246 T803N 803 T N 0.152 Neutral MSH2 P43246 T803P 803 T P 0.686 Pathogenic MSH2 P43246 T803Q 803 T Q 0.1 Neutral MSH2 P43246 T803R 803 T R 0.86 Pathogenic MSH2 P43246 T803S 803 T S 0.014 Neutral MSH2 P43246 T803V 803 T V 0.118 Neutral MSH2 P43246 T803W 803 T W 0.912 Pathogenic MSH2 P43246 T803Y 803 T Y 0.876 Pathogenic MSH2 P43246 A804C 804 A C 0.862 Pathogenic MSH2 P43246 A804D 804 A D 0.922 Pathogenic MSH2 P43246 A804E 804 A E 0.876 Pathogenic MSH2 P43246 A804F 804 A F 0.966 Pathogenic MSH2 P43246 A804G 804 A G 0.734 Pathogenic MSH2 P43246 A804H 804 A H 0.866 Pathogenic MSH2 P43246 A804I 804 A I 0.93 Pathogenic MSH2 P43246 A804K 804 A K 0.936 Pathogenic MSH2 P43246 A804L 804 A L 0.98 Pathogenic MSH2 P43246 A804M 804 A M 0.854 Pathogenic MSH2 P43246 A804N 804 A N 0.854 Pathogenic MSH2 P43246 A804P 804 A P 0.958 Pathogenic MSH2 P43246 A804Q 804 A Q 0.814 Pathogenic MSH2 P43246 A804R 804 A R 0.954 Pathogenic MSH2 P43246 A804S 804 A S 0.424 Neutral MSH2 P43246 A804T 804 A T 0.464 Neutral MSH2 P43246 A804V 804 A V 0.748 Pathogenic MSH2 P43246 A804W 804 A W 0.976 Pathogenic MSH2 P43246 A804Y 804 A Y 0.926 Pathogenic MSH2 P43246 L805A 805 L A 0.202 Neutral MSH2 P43246 L805C 805 L C 0.65 Pathogenic MSH2 P43246 L805D 805 L D 0.922 Pathogenic MSH2 P43246 L805E 805 L E 0.516 Pathogenic MSH2 P43246 L805F 805 L F 0.418 Neutral MSH2 P43246 L805G 805 L G 0.816 Pathogenic MSH2 P43246 L805H 805 L H 0.182 Neutral MSH2 P43246 L805I 805 L I 0.164 Neutral MSH2 P43246 L805K 805 L K 0.656 Pathogenic MSH2 P43246 L805M 805 L M 0.168 Neutral MSH2 P43246 L805N 805 L N 0.516 Pathogenic MSH2 P43246 L805P 805 L P 0.944 Pathogenic MSH2 P43246 L805Q 805 L Q 0.138 Neutral MSH2 P43246 L805R 805 L R 0.986 Pathogenic MSH2 P43246 L805S 805 L S 0.158 Neutral MSH2 P43246 L805T 805 L T 0.346 Neutral MSH2 P43246 L805V 805 L V 0.104 Neutral MSH2 P43246 L805W 805 L W 0.81 Pathogenic MSH2 P43246 L805Y 805 L Y 0.79 Pathogenic MSH2 P43246 T806A 806 T A 0.136 Neutral MSH2 P43246 T806C 806 T C 0.806 Pathogenic MSH2 P43246 T806D 806 T D 0.82 Pathogenic MSH2 P43246 T806E 806 T E 0.888 Pathogenic MSH2 P43246 T806F 806 T F 0.906 Pathogenic MSH2 P43246 T806G 806 T G 0.57 Pathogenic MSH2 P43246 T806H 806 T H 0.832 Pathogenic MSH2 P43246 T806I 806 T I 0.286 Neutral MSH2 P43246 T806K 806 T K 0.846 Pathogenic MSH2 P43246 T806L 806 T L 0.562 Pathogenic MSH2 P43246 T806M 806 T M 0.492 Neutral MSH2 P43246 T806N 806 T N 0.268 Neutral MSH2 P43246 T806P 806 T P 0.898 Pathogenic MSH2 P43246 T806Q 806 T Q 0.744 Pathogenic MSH2 P43246 T806R 806 T R 0.952 Pathogenic MSH2 P43246 T806S 806 T S 0.658 Pathogenic MSH2 P43246 T806V 806 T V 0.286 Neutral MSH2 P43246 T806W 806 T W 0.98 Pathogenic MSH2 P43246 T806Y 806 T Y 0.98 Pathogenic MSH2 P43246 T807A 807 T A 0.058 Neutral MSH2 P43246 T807C 807 T C 0.356 Neutral MSH2 P43246 T807D 807 T D 0.108 Neutral MSH2 P43246 T807E 807 T E 0.144 Neutral MSH2 P43246 T807F 807 T F 0.76 Pathogenic MSH2 P43246 T807G 807 T G 0.028 Neutral MSH2 P43246 T807H 807 T H 0.606 Pathogenic MSH2 P43246 T807I 807 T I 0.59 Pathogenic MSH2 P43246 T807K 807 T K 0.116 Neutral MSH2 P43246 T807L 807 T L 0.59 Pathogenic MSH2 P43246 T807M 807 T M 0.716 Pathogenic MSH2 P43246 T807N 807 T N 0.02 Neutral MSH2 P43246 T807P 807 T P 0.672 Pathogenic MSH2 P43246 T807Q 807 T Q 0.052 Neutral MSH2 P43246 T807R 807 T R 0.848 Pathogenic MSH2 P43246 T807S 807 T S 0.008 Neutral MSH2 P43246 T807V 807 T V 0.724 Pathogenic MSH2 P43246 T807W 807 T W 0.95 Pathogenic MSH2 P43246 T807Y 807 T Y 0.946 Pathogenic MSH2 P43246 E808A 808 E A 0.224 Neutral MSH2 P43246 E808C 808 E C 0.124 Neutral MSH2 P43246 E808D 808 E D 0.002 Neutral MSH2 P43246 E808F 808 E F 0.436 Neutral MSH2 P43246 E808G 808 E G 0.004 Neutral MSH2 P43246 E808H 808 E H 0.02 Neutral MSH2 P43246 E808I 808 E I 0.52 Pathogenic MSH2 P43246 E808K 808 E K 0.004 Neutral MSH2 P43246 E808L 808 E L 0.464 Neutral MSH2 P43246 E808M 808 E M 0.298 Neutral MSH2 P43246 E808N 808 E N 0.002 Neutral MSH2 P43246 E808P 808 E P 0.474 Neutral MSH2 P43246 E808Q 808 E Q 0 Neutral MSH2 P43246 E808R 808 E R 0.022 Neutral MSH2 P43246 E808S 808 E S 0.018 Neutral MSH2 P43246 E808T 808 E T 0.13 Neutral MSH2 P43246 E808V 808 E V 0.416 Neutral MSH2 P43246 E808W 808 E W 0.712 Pathogenic MSH2 P43246 E808Y 808 E Y 0.588 Pathogenic MSH2 P43246 E809A 809 E A 0.312 Neutral MSH2 P43246 E809C 809 E C 0.208 Neutral MSH2 P43246 E809D 809 E D 0.004 Neutral MSH2 P43246 E809F 809 E F 0.638 Pathogenic MSH2 P43246 E809G 809 E G 0.016 Neutral MSH2 P43246 E809H 809 E H 0.234 Neutral MSH2 P43246 E809I 809 E I 0.638 Pathogenic MSH2 P43246 E809K 809 E K 0.018 Neutral MSH2 P43246 E809L 809 E L 0.63 Pathogenic MSH2 P43246 E809M 809 E M 0.446 Neutral MSH2 P43246 E809N 809 E N 0.004 Neutral MSH2 P43246 E809P 809 E P 0.652 Pathogenic MSH2 P43246 E809Q 809 E Q 0.004 Neutral MSH2 P43246 E809R 809 E R 0.04 Neutral MSH2 P43246 E809S 809 E S 0.036 Neutral MSH2 P43246 E809T 809 E T 0.08 Neutral MSH2 P43246 E809V 809 E V 0.596 Pathogenic MSH2 P43246 E809W 809 E W 0.822 Pathogenic MSH2 P43246 E809Y 809 E Y 0.708 Pathogenic MSH2 P43246 S81A 81 S A 0.22 Neutral MSH2 P43246 S81C 81 S C 0.148 Neutral MSH2 P43246 S81D 81 S D 0.13 Neutral MSH2 P43246 S81E 81 S E 0.302 Neutral MSH2 P43246 S81F 81 S F 0.64 Pathogenic MSH2 P43246 S81G 81 S G 0.184 Neutral MSH2 P43246 S81H 81 S H 0.348 Neutral MSH2 P43246 S81I 81 S I 0.226 Neutral MSH2 P43246 S81K 81 S K 0.316 Neutral MSH2 P43246 S81L 81 S L 0.062 Neutral MSH2 P43246 S81M 81 S M 0.458 Neutral MSH2 P43246 S81N 81 S N 0.008 Neutral MSH2 P43246 S81P 81 S P 0.082 Neutral MSH2 P43246 S81Q 81 S Q 0.336 Neutral MSH2 P43246 S81R 81 S R 0.32 Neutral MSH2 P43246 S81T 81 S T 0.024 Neutral MSH2 P43246 S81V 81 S V 0.052 Neutral MSH2 P43246 S81W 81 S W 0.84 Pathogenic MSH2 P43246 S81Y 81 S Y 0.652 Pathogenic MSH2 P43246 T810A 810 T A 0.07 Neutral MSH2 P43246 T810C 810 T C 0.442 Neutral MSH2 P43246 T810D 810 T D 0.094 Neutral MSH2 P43246 T810E 810 T E 0.144 Neutral MSH2 P43246 T810F 810 T F 0.688 Pathogenic MSH2 P43246 T810G 810 T G 0.272 Neutral MSH2 P43246 T810H 810 T H 0.228 Neutral MSH2 P43246 T810I 810 T I 0.494 Neutral MSH2 P43246 T810K 810 T K 0.074 Neutral MSH2 P43246 T810L 810 T L 0.496 Neutral MSH2 P43246 T810M 810 T M 0.374 Neutral MSH2 P43246 T810N 810 T N 0.182 Neutral MSH2 P43246 T810P 810 T P 0.59 Pathogenic MSH2 P43246 T810Q 810 T Q 0.016 Neutral MSH2 P43246 T810R 810 T R 0.558 Pathogenic MSH2 P43246 T810S 810 T S 0.016 Neutral MSH2 P43246 T810V 810 T V 0.71 Pathogenic MSH2 P43246 T810W 810 T W 0.914 Pathogenic MSH2 P43246 T810Y 810 T Y 0.908 Pathogenic MSH2 P43246 L811A 811 L A 0.564 Pathogenic MSH2 P43246 L811C 811 L C 0.684 Pathogenic MSH2 P43246 L811D 811 L D 0.898 Pathogenic MSH2 P43246 L811E 811 L E 0.878 Pathogenic MSH2 P43246 L811F 811 L F 0.468 Neutral MSH2 P43246 L811G 811 L G 0.8 Pathogenic MSH2 P43246 L811H 811 L H 0.8 Pathogenic MSH2 P43246 L811I 811 L I 0.14 Neutral MSH2 P43246 L811K 811 L K 0.742 Pathogenic MSH2 P43246 L811M 811 L M 0.454 Neutral MSH2 P43246 L811N 811 L N 0.768 Pathogenic MSH2 P43246 L811P 811 L P 0.684 Pathogenic MSH2 P43246 L811Q 811 L Q 0.616 Pathogenic MSH2 P43246 L811R 811 L R 0.996 Pathogenic MSH2 P43246 L811S 811 L S 0.608 Pathogenic MSH2 P43246 L811T 811 L T 0.586 Pathogenic MSH2 P43246 L811V 811 L V 0.084 Neutral MSH2 P43246 L811W 811 L W 0.934 Pathogenic MSH2 P43246 L811Y 811 L Y 0.894 Pathogenic MSH2 P43246 T812A 812 T A 0.502 Pathogenic MSH2 P43246 T812C 812 T C 0.67 Pathogenic MSH2 P43246 T812D 812 T D 0.954 Pathogenic MSH2 P43246 T812E 812 T E 0.952 Pathogenic MSH2 P43246 T812F 812 T F 0.95 Pathogenic MSH2 P43246 T812G 812 T G 0.746 Pathogenic MSH2 P43246 T812H 812 T H 0.926 Pathogenic MSH2 P43246 T812I 812 T I 0.712 Pathogenic MSH2 P43246 T812K 812 T K 0.94 Pathogenic MSH2 P43246 T812L 812 T L 0.952 Pathogenic MSH2 P43246 T812M 812 T M 0.984 Pathogenic MSH2 P43246 T812N 812 T N 0.898 Pathogenic MSH2 P43246 T812P 812 T P 0.754 Pathogenic MSH2 P43246 T812Q 812 T Q 0.894 Pathogenic MSH2 P43246 T812R 812 T R 0.994 Pathogenic MSH2 P43246 T812S 812 T S 0.388 Neutral MSH2 P43246 T812V 812 T V 0.49 Neutral MSH2 P43246 T812W 812 T W 0.976 Pathogenic MSH2 P43246 T812Y 812 T Y 0.976 Pathogenic MSH2 P43246 M813A 813 M A 0.684 Pathogenic MSH2 P43246 M813C 813 M C 0.618 Pathogenic MSH2 P43246 M813D 813 M D 0.876 Pathogenic MSH2 P43246 M813E 813 M E 0.814 Pathogenic MSH2 P43246 M813F 813 M F 0.374 Neutral MSH2 P43246 M813G 813 M G 0.536 Pathogenic MSH2 P43246 M813H 813 M H 0.934 Pathogenic MSH2 P43246 M813I 813 M I 0.836 Pathogenic MSH2 P43246 M813K 813 M K 0.956 Pathogenic MSH2 P43246 M813L 813 M L 0.236 Neutral MSH2 P43246 M813N 813 M N 0.904 Pathogenic MSH2 P43246 M813P 813 M P 0.632 Pathogenic MSH2 P43246 M813Q 813 M Q 0.788 Pathogenic MSH2 P43246 M813R 813 M R 0.954 Pathogenic MSH2 P43246 M813S 813 M S 0.398 Neutral MSH2 P43246 M813T 813 M T 0.76 Pathogenic MSH2 P43246 M813V 813 M V 0.218 Neutral 2 MSH2 P43246 M813W 813 M W 0.984 Pathogenic MSH2 P43246 M813Y 813 M Y 0.976 Pathogenic MSH2 P43246 L814A 814 L A 0.718 Pathogenic MSH2 P43246 L814C 814 L C 0.83 Pathogenic MSH2 P43246 L814D 814 L D 0.912 Pathogenic MSH2 P43246 L814E 814 L E 0.894 Pathogenic MSH2 P43246 L814F 814 L F 0.806 Pathogenic MSH2 P43246 L814G 814 L G 0.864 Pathogenic MSH2 P43246 L814H 814 L H 0.908 Pathogenic MSH2 P43246 L814I 814 L I 0.94 Pathogenic MSH2 P43246 L814K 814 L K 0.734 Pathogenic MSH2 P43246 L814M 814 L M 0.498 Neutral MSH2 P43246 L814N 814 L N 0.822 Pathogenic MSH2 P43246 L814P 814 L P 0.862 Pathogenic MSH2 P43246 L814Q 814 L Q 0.778 Pathogenic MSH2 P43246 L814R 814 L R 0.982 Pathogenic MSH2 P43246 L814S 814 L S 0.716 Pathogenic MSH2 P43246 L814T 814 L T 0.638 Pathogenic MSH2 P43246 L814V 814 L V 0.456 Neutral MSH2 P43246 L814W 814 L W 0.886 Pathogenic MSH2 P43246 L814Y 814 L Y 0.896 Pathogenic MSH2 P43246 Y815A 815 Y A 0.442 Neutral MSH2 P43246 Y815C 815 Y C 0.696 Pathogenic MSH2 P43246 Y815D 815 Y D 0.852 Pathogenic MSH2 P43246 Y815E 815 Y E 0.766 Pathogenic MSH2 P43246 Y815F 815 Y F 0.526 Pathogenic MSH2 P43246 Y815G 815 Y G 0.486 Neutral MSH2 P43246 Y815H 815 Y H 0.438 Neutral MSH2 P43246 Y815I 815 Y I 0.806 Pathogenic MSH2 P43246 Y815K 815 Y K 0.832 Pathogenic MSH2 P43246 Y815L 815 Y L 0.46 Neutral MSH2 P43246 Y815M 815 Y M 0.702 Pathogenic MSH2 P43246 Y815N 815 Y N 0.75 Pathogenic MSH2 P43246 Y815P 815 Y P 0.794 Pathogenic MSH2 P43246 Y815Q 815 Y Q 0.674 Pathogenic MSH2 P43246 Y815R 815 Y R 0.796 Pathogenic MSH2 P43246 Y815S 815 Y S 0.486 Neutral MSH2 P43246 Y815T 815 Y T 0.692 Pathogenic MSH2 P43246 Y815V 815 Y V 0.472 Neutral MSH2 P43246 Y815W 815 Y W 0.914 Pathogenic MSH2 P43246 Q816A 816 Q A 0.39 Neutral MSH2 P43246 Q816C 816 Q C 0.664 Pathogenic MSH2 P43246 Q816D 816 Q D 0.384 Neutral MSH2 P43246 Q816E 816 Q E 0.636 Pathogenic MSH2 P43246 Q816F 816 Q F 0.924 Pathogenic MSH2 P43246 Q816G 816 Q G 0.572 Pathogenic MSH2 P43246 Q816H 816 Q H 0.844 Pathogenic MSH2 P43246 Q816I 816 Q I 0.952 Pathogenic MSH2 P43246 Q816K 816 Q K 0.43 Neutral MSH2 P43246 Q816L 816 Q L 0.878 Pathogenic MSH2 P43246 Q816M 816 Q M 0.91 Pathogenic MSH2 P43246 Q816N 816 Q N 0.378 Neutral MSH2 P43246 Q816P 816 Q P 0.918 Pathogenic MSH2 P43246 Q816R 816 Q R 0.318 Neutral MSH2 P43246 Q816S 816 Q S 0.85 Pathogenic MSH2 P43246 Q816T 816 Q T 0.424 Neutral MSH2 P43246 Q816V 816 Q V 0.92 Pathogenic MSH2 P43246 Q816W 816 Q W 0.96 Pathogenic MSH2 P43246 Q816Y 816 Q Y 0.95 Pathogenic MSH2 P43246 V817A 817 V A 0.4 Neutral MSH2 P43246 V817C 817 V C 0.808 Pathogenic MSH2 P43246 V817D 817 V D 0.864 Pathogenic MSH2 P43246 V817E 817 V E 0.958 Pathogenic MSH2 P43246 V817F 817 V F 0.93 Pathogenic MSH2 P43246 V817G 817 V G 0.916 Pathogenic MSH2 P43246 V817H 817 V H 0.91 Pathogenic MSH2 P43246 V817I 817 V I 0.424 Neutral MSH2 P43246 V817K 817 V K 0.982 Pathogenic MSH2 P43246 V817L 817 V L 0.688 Pathogenic MSH2 P43246 V817M 817 V M 0.918 Pathogenic MSH2 P43246 V817N 817 V N 0.92 Pathogenic MSH2 P43246 V817P 817 V P 0.99 Pathogenic MSH2 P43246 V817Q 817 V Q 0.964 Pathogenic MSH2 P43246 V817R 817 V R 0.95 Pathogenic MSH2 P43246 V817S 817 V S 0.81 Pathogenic MSH2 P43246 V817T 817 V T 0.878 Pathogenic MSH2 P43246 V817W 817 V W 0.954 Pathogenic MSH2 P43246 V817Y 817 V Y 0.974 Pathogenic MSH2 P43246 K818A 818 K A 0.072 Neutral MSH2 P43246 K818C 818 K C 0.074 Neutral MSH2 P43246 K818D 818 K D 0.02 Neutral MSH2 P43246 K818E 818 K E 0.062 Neutral MSH2 P43246 K818F 818 K F 0.794 Pathogenic MSH2 P43246 K818G 818 K G 0.354 Neutral MSH2 P43246 K818H 818 K H 0.144 Neutral MSH2 P43246 K818I 818 K I 0.696 Pathogenic MSH2 P43246 K818L 818 K L 0.632 Pathogenic MSH2 P43246 K818M 818 K M 0.116 Neutral MSH2 P43246 K818N 818 K N 0.03 Neutral MSH2 P43246 K818P 818 K P 0.644 Pathogenic MSH2 P43246 K818Q 818 K Q 0.034 Neutral MSH2 P43246 K818R 818 K R 0.042 Neutral MSH2 P43246 K818S 818 K S 0.386 Neutral MSH2 P43246 K818T 818 K T 0.116 Neutral MSH2 P43246 K818V 818 K V 0.126 Neutral MSH2 P43246 K818W 818 K W 0.94 Pathogenic MSH2 P43246 K818Y 818 K Y 0.888 Pathogenic MSH2 P43246 K819A 819 K A 0.124 Neutral MSH2 P43246 K819C 819 K C 0.432 Neutral MSH2 P43246 K819D 819 K D 0.08 Neutral MSH2 P43246 K819E 819 K E 0.078 Neutral MSH2 P43246 K819F 819 K F 0.964 Pathogenic MSH2 P43246 K819G 819 K G 0.536 Pathogenic MSH2 P43246 K819H 819 K H 0.736 Pathogenic MSH2 P43246 K819I 819 K I 0.988 Pathogenic MSH2 P43246 K819L 819 K L 0.448 Neutral MSH2 P43246 K819M 819 K M 0.922 Pathogenic MSH2 P43246 K819N 819 K N 0.248 Neutral MSH2 P43246 K819P 819 K P 0.456 Neutral MSH2 P43246 K819Q 819 K Q 0.104 Neutral MSH2 P43246 K819R 819 K R 0.732 Pathogenic MSH2 P43246 K819S 819 K S 0.146 Neutral MSH2 P43246 K819T 819 K T 0.3 Neutral MSH2 P43246 K819V 819 K V 0.878 Pathogenic MSH2 P43246 K819W 819 K W 0.992 Pathogenic MSH2 P43246 K819Y 819 K Y 0.984 Pathogenic MSH2 P43246 K82A 82 K A 0.084 Neutral MSH2 P43246 K82C 82 K C 0.172 Neutral MSH2 P43246 K82D 82 K D 0.27 Neutral MSH2 P43246 K82E 82 K E 0.176 Neutral MSH2 P43246 K82F 82 K F 0.802 Pathogenic MSH2 P43246 K82G 82 K G 0.112 Neutral MSH2 P43246 K82H 82 K H 0.334 Neutral MSH2 P43246 K82I 82 K I 0.454 Neutral MSH2 P43246 K82L 82 K L 0.108 Neutral MSH2 P43246 K82M 82 K M 0.098 Neutral MSH2 P43246 K82N 82 K N 0.034 Neutral MSH2 P43246 K82P 82 K P 0.796 Pathogenic MSH2 P43246 K82Q 82 K Q 0.04 Neutral MSH2 P43246 K82R 82 K R 0.06 Neutral MSH2 P43246 K82S 82 K S 0.034 Neutral MSH2 P43246 K82T 82 K T 0.04 Neutral MSH2 P43246 K82V 82 K V 0.678 Pathogenic MSH2 P43246 K82W 82 K W 0.976 Pathogenic MSH2 P43246 K82Y 82 K Y 0.92 Pathogenic MSH2 P43246 G820A 820 G A 0.966 Pathogenic MSH2 P43246 G820C 820 G C 0.948 Pathogenic MSH2 P43246 G820D 820 G D 1 Pathogenic MSH2 P43246 G820E 820 G E 0.988 Pathogenic MSH2 P43246 G820F 820 G F 0.984 Pathogenic MSH2 P43246 G820H 820 G H 0.988 Pathogenic MSH2 P43246 G820I 820 G I 0.974 Pathogenic MSH2 P43246 G820K 820 G K 0.988 Pathogenic MSH2 P43246 G820L 820 G L 0.984 Pathogenic MSH2 P43246 G820M 820 G M 0.994 Pathogenic MSH2 P43246 G820N 820 G N 0.986 Pathogenic MSH2 P43246 G820P 820 G P 0.966 Pathogenic MSH2 P43246 G820Q 820 G Q 0.994 Pathogenic MSH2 P43246 G820R 820 G R 1 Pathogenic MSH2 P43246 G820S 820 G S 0.832 Pathogenic MSH2 P43246 G820T 820 G T 0.846 Pathogenic MSH2 P43246 G820V 820 G V 0.986 Pathogenic MSH2 P43246 G820W 820 G W 0.98 Pathogenic MSH2 P43246 G820Y 820 G Y 0.96 Pathogenic MSH2 P43246 V821A 821 V A 0.08 Neutral MSH2 P43246 V821C 821 V C 0.344 Neutral MSH2 P43246 V821D 821 V D 0.87 Pathogenic MSH2 P43246 V821E 821 V E 0.584 Pathogenic MSH2 P43246 V821F 821 V F 0.532 Pathogenic MSH2 P43246 V821G 821 V G 0.908 Pathogenic MSH2 P43246 V821H 821 V H 0.808 Pathogenic MSH2 P43246 V821I 821 V I 0.158 Neutral MSH2 P43246 V821K 821 V K 0.974 Pathogenic MSH2 P43246 V821L 821 V L 0.824 Pathogenic MSH2 P43246 V821M 821 V M 0.806 Pathogenic MSH2 P43246 V821N 821 V N 0.934 Pathogenic MSH2 P43246 V821P 821 V P 0.292 Neutral MSH2 P43246 V821Q 821 V Q 0.992 Pathogenic MSH2 P43246 V821R 821 V R 0.96 Pathogenic MSH2 P43246 V821S 821 V S 0.144 Neutral MSH2 P43246 V821T 821 V T 0.74 Pathogenic MSH2 P43246 V821W 821 V W 0.9 Pathogenic MSH2 P43246 V821Y 821 V Y 0.926 Pathogenic MSH2 P43246 C822A 822 C A 0.274 Neutral MSH2 P43246 C822D 822 C D 0.95 Pathogenic MSH2 P43246 C822E 822 C E 0.886 Pathogenic MSH2 P43246 C822F 822 C F 0.992 Pathogenic MSH2 P43246 C822G 822 C G 0.192 Neutral MSH2 P43246 C822H 822 C H 0.868 Pathogenic MSH2 P43246 C822I 822 C I 0.794 Pathogenic MSH2 P43246 C822K 822 C K 0.892 Pathogenic MSH2 P43246 C822L 822 C L 0.986 Pathogenic MSH2 P43246 C822M 822 C M 0.32 Neutral MSH2 P43246 C822N 822 C N 0.812 Pathogenic MSH2 P43246 C822P 822 C P 0.974 Pathogenic MSH2 P43246 C822Q 822 C Q 0.692 Pathogenic MSH2 P43246 C822R 822 C R 0.744 Pathogenic MSH2 P43246 C822S 822 C S 0.088 Neutral MSH2 P43246 C822T 822 C T 0.758 Pathogenic MSH2 P43246 C822V 822 C V 0.958 Pathogenic MSH2 P43246 C822W 822 C W 0.992 Pathogenic MSH2 P43246 C822Y 822 C Y 0.988 Pathogenic MSH2 P43246 D823A 823 D A 0.558 Pathogenic MSH2 P43246 D823C 823 D C 0.878 Pathogenic MSH2 P43246 D823E 823 D E 0.416 Neutral MSH2 P43246 D823F 823 D F 0.98 Pathogenic MSH2 P43246 D823G 823 D G 0.932 Pathogenic MSH2 P43246 D823H 823 D H 0.62 Pathogenic MSH2 P43246 D823I 823 D I 0.974 Pathogenic MSH2 P43246 D823K 823 D K 0.918 Pathogenic MSH2 P43246 D823L 823 D L 0.976 Pathogenic MSH2 P43246 D823M 823 D M 0.956 Pathogenic MSH2 P43246 D823N 823 D N 0.852 Pathogenic MSH2 P43246 D823P 823 D P 0.752 Pathogenic MSH2 P43246 D823Q 823 D Q 0.444 Neutral MSH2 P43246 D823R 823 D R 0.958 Pathogenic MSH2 P43246 D823S 823 D S 0.562 Pathogenic MSH2 P43246 D823T 823 D T 0.794 Pathogenic MSH2 P43246 D823V 823 D V 0.996 Pathogenic MSH2 P43246 D823W 823 D W 0.98 Pathogenic MSH2 P43246 D823Y 823 D Y 0.972 Pathogenic MSH2 P43246 Q824A 824 Q A 0.776 Pathogenic MSH2 P43246 Q824C 824 Q C 0.75 Pathogenic MSH2 P43246 Q824D 824 Q D 0.842 Pathogenic MSH2 P43246 Q824E 824 Q E 0.48 Neutral MSH2 P43246 Q824F 824 Q F 0.902 Pathogenic MSH2 P43246 Q824G 824 Q G 0.526 Pathogenic MSH2 P43246 Q824H 824 Q H 0.878 Pathogenic MSH2 P43246 Q824I 824 Q I 0.932 Pathogenic MSH2 P43246 Q824K 824 Q K 0.282 Neutral MSH2 P43246 Q824L 824 Q L 0.834 Pathogenic MSH2 P43246 Q824M 824 Q M 0.87 Pathogenic MSH2 P43246 Q824N 824 Q N 0.484 Neutral MSH2 P43246 Q824P 824 Q P 0.898 Pathogenic MSH2 P43246 Q824R 824 Q R 0.418 Neutral MSH2 P43246 Q824S 824 Q S 0.3 Neutral MSH2 P43246 Q824T 824 Q T 0.438 Neutral MSH2 P43246 Q824V 824 Q V 0.908 Pathogenic MSH2 P43246 Q824W 824 Q W 0.938 Pathogenic MSH2 P43246 Q824Y 824 Q Y 0.928 Pathogenic MSH2 P43246 S825A 825 S A 0.872 Pathogenic MSH2 P43246 S825C 825 S C 0.906 Pathogenic MSH2 P43246 S825D 825 S D 0.914 Pathogenic MSH2 P43246 S825E 825 S E 0.964 Pathogenic MSH2 P43246 S825F 825 S F 0.982 Pathogenic MSH2 P43246 S825G 825 S G 0.7 Pathogenic MSH2 P43246 S825H 825 S H 0.974 Pathogenic MSH2 P43246 S825I 825 S I 0.886 Pathogenic MSH2 P43246 S825K 825 S K 0.954 Pathogenic MSH2 P43246 S825L 825 S L 0.926 Pathogenic MSH2 P43246 S825M 825 S M 0.998 Pathogenic MSH2 P43246 S825N 825 S N 0.892 Pathogenic MSH2 P43246 S825P 825 S P 0.97 Pathogenic MSH2 P43246 S825Q 825 S Q 0.952 Pathogenic MSH2 P43246 S825R 825 S R 0.974 Pathogenic MSH2 P43246 S825T 825 S T 0.762 Pathogenic MSH2 P43246 S825V 825 S V 0.958 Pathogenic MSH2 P43246 S825W 825 S W 0.956 Pathogenic MSH2 P43246 S825Y 825 S Y 0.964 Pathogenic MSH2 P43246 F826A 826 F A 0.492 Neutral MSH2 P43246 F826C 826 F C 0.724 Pathogenic MSH2 P43246 F826D 826 F D 0.81 Pathogenic MSH2 P43246 F826E 826 F E 0.864 Pathogenic MSH2 P43246 F826G 826 F G 0.498 Neutral MSH2 P43246 F826H 826 F H 0.768 Pathogenic MSH2 P43246 F826I 826 F I 0.69 Pathogenic MSH2 P43246 F826K 826 F K 0.844 Pathogenic MSH2 P43246 F826L 826 F L 0.368 Neutral MSH2 P43246 F826M 826 F M 0.784 Pathogenic MSH2 P43246 F826N 826 F N 0.76 Pathogenic MSH2 P43246 F826P 826 F P 0.95 Pathogenic MSH2 P43246 F826Q 826 F Q 0.782 Pathogenic MSH2 P43246 F826R 826 F R 0.912 Pathogenic MSH2 P43246 F826S 826 F S 0.864 Pathogenic MSH2 P43246 F826T 826 F T 0.588 Pathogenic MSH2 P43246 F826V 826 F V 0.746 Pathogenic MSH2 P43246 F826W 826 F W 0.868 Pathogenic MSH2 P43246 F826Y 826 F Y 0.576 Pathogenic MSH2 P43246 G827A 827 G A 0.966 Pathogenic MSH2 P43246 G827C 827 G C 0.948 Pathogenic MSH2 P43246 G827D 827 G D 1 Pathogenic MSH2 P43246 G827E 827 G E 0.988 Pathogenic MSH2 P43246 G827F 827 G F 0.984 Pathogenic MSH2 P43246 G827H 827 G H 0.988 Pathogenic MSH2 P43246 G827I 827 G I 0.974 Pathogenic MSH2 P43246 G827K 827 G K 0.988 Pathogenic MSH2 P43246 G827L 827 G L 0.984 Pathogenic MSH2 P43246 G827M 827 G M 0.994 Pathogenic MSH2 P43246 G827N 827 G N 0.986 Pathogenic MSH2 P43246 G827P 827 G P 0.966 Pathogenic MSH2 P43246 G827Q 827 G Q 0.994 Pathogenic MSH2 P43246 G827R 827 G R 1 Pathogenic MSH2 P43246 G827S 827 G S 0.832 Pathogenic MSH2 P43246 G827T 827 G T 0.846 Pathogenic MSH2 P43246 G827V 827 G V 0.986 Pathogenic MSH2 P43246 G827W 827 G W 0.936 Pathogenic MSH2 P43246 G827Y 827 G Y 0.96 Pathogenic MSH2 P43246 I828A 828 I A 0.642 Pathogenic MSH2 P43246 I828C 828 I C 0.734 Pathogenic MSH2 P43246 I828D 828 I D 0.806 Pathogenic MSH2 P43246 I828E 828 I E 0.676 Pathogenic MSH2 P43246 I828F 828 I F 0.844 Pathogenic MSH2 P43246 I828G 828 I G 0.866 Pathogenic MSH2 P43246 I828H 828 I H 0.904 Pathogenic MSH2 P43246 I828K 828 I K 0.84 Pathogenic MSH2 P43246 I828L 828 I L 0.294 Neutral MSH2 P43246 I828M 828 I M 0.658 Pathogenic MSH2 P43246 I828N 828 I N 0.828 Pathogenic MSH2 P43246 I828P 828 I P 0.928 Pathogenic MSH2 P43246 I828Q 828 I Q 0.834 Pathogenic MSH2 P43246 I828R 828 I R 0.898 Pathogenic MSH2 P43246 I828S 828 I S 0.704 Pathogenic MSH2 P43246 I828T 828 I T 0.344 Neutral MSH2 P43246 I828V 828 I V 0.546 Pathogenic MSH2 P43246 I828W 828 I W 0.896 Pathogenic MSH2 P43246 I828Y 828 I Y 0.872 Pathogenic MSH2 P43246 H829A 829 H A 0.71 Pathogenic MSH2 P43246 H829C 829 H C 0.684 Pathogenic MSH2 P43246 H829D 829 H D 0.616 Pathogenic MSH2 P43246 H829E 829 H E 0.356 Neutral MSH2 P43246 H829F 829 H F 0.874 Pathogenic MSH2 P43246 H829G 829 H G 0.51 Pathogenic MSH2 P43246 H829I 829 H I 0.876 Pathogenic MSH2 P43246 H829K 829 H K 0.354 Neutral MSH2 P43246 H829L 829 H L 0.694 Pathogenic MSH2 P43246 H829M 829 H M 0.596 Pathogenic MSH2 P43246 H829N 829 H N 0.204 Neutral MSH2 P43246 H829P 829 H P 0.976 Pathogenic MSH2 P43246 H829Q 829 H Q 0.224 Neutral MSH2 P43246 H829R 829 H R 0.898 Pathogenic MSH2 P43246 H829S 829 H S 0.636 Pathogenic MSH2 P43246 H829T 829 H T 0.516 Pathogenic MSH2 P43246 H829V 829 H V 0.668 Pathogenic MSH2 P43246 H829W 829 H W 0.94 Pathogenic MSH2 P43246 H829Y 829 H Y 0.89 Pathogenic MSH2 P43246 M83A 83 M A 0.142 Neutral MSH2 P43246 M83C 83 M C 0.208 Neutral MSH2 P43246 M83D 83 M D 0.61 Pathogenic MSH2 P43246 M83E 83 M E 0.368 Neutral MSH2 P43246 M83F 83 M F 0.782 Pathogenic MSH2 P43246 M83G 83 M G 0.096 Neutral MSH2 P43246 M83H 83 M H 0.418 Neutral MSH2 P43246 M83I 83 M I 0.102 Neutral MSH2 P43246 M83K 83 M K 0.224 Neutral MSH2 P43246 M83L 83 M L 0.07 Neutral MSH2 P43246 M83N 83 M N 0.106 Neutral MSH2 P43246 M83P 83 M P 0.252 Neutral MSH2 P43246 M83Q 83 M Q 0.134 Neutral MSH2 P43246 M83R 83 M R 0.64 Pathogenic MSH2 P43246 M83S 83 M S 0.05 Neutral MSH2 P43246 M83T 83 M T 0.246 Neutral MSH2 P43246 M83V 83 M V 0.08 Neutral MSH2 P43246 M83W 83 M W 0.96 Pathogenic MSH2 P43246 M83Y 83 M Y 0.864 Pathogenic MSH2 P43246 V830A 830 V A 0.526 Pathogenic MSH2 P43246 V830C 830 V C 0.422 Neutral MSH2 P43246 V830D 830 V D 0.864 Pathogenic MSH2 P43246 V830E 830 V E 0.958 Pathogenic MSH2 P43246 V830F 830 V F 0.93 Pathogenic MSH2 P43246 V830G 830 V G 0.91 Pathogenic MSH2 P43246 V830H 830 V H 0.912 Pathogenic MSH2 P43246 V830I 830 V I 0.458 Neutral MSH2 P43246 V830K 830 V K 0.982 Pathogenic MSH2 P43246 V830L 830 V L 0.946 Pathogenic MSH2 P43246 V830M 830 V M 0.92 Pathogenic MSH2 P43246 V830N 830 V N 0.918 Pathogenic MSH2 P43246 V830P 830 V P 0.986 Pathogenic MSH2 P43246 V830Q 830 V Q 0.964 Pathogenic MSH2 P43246 V830R 830 V R 0.95 Pathogenic MSH2 P43246 V830S 830 V S 0.81 Pathogenic MSH2 P43246 V830T 830 V T 0.878 Pathogenic MSH2 P43246 V830W 830 V W 0.954 Pathogenic MSH2 P43246 V830Y 830 V Y 0.974 Pathogenic MSH2 P43246 A831C 831 A C 0.87 Pathogenic MSH2 P43246 A831D 831 A D 0.93 Pathogenic MSH2 P43246 A831E 831 A E 0.884 Pathogenic MSH2 P43246 A831F 831 A F 0.97 Pathogenic MSH2 P43246 A831G 831 A G 0.512 Pathogenic MSH2 P43246 A831H 831 A H 0.872 Pathogenic MSH2 P43246 A831I 831 A I 0.962 Pathogenic MSH2 P43246 A831K 831 A K 0.94 Pathogenic MSH2 P43246 A831L 831 A L 0.928 Pathogenic MSH2 P43246 A831M 831 A M 0.86 Pathogenic MSH2 P43246 A831N 831 A N 0.864 Pathogenic MSH2 P43246 A831P 831 A P 0.966 Pathogenic MSH2 P43246 A831Q 831 A Q 0.824 Pathogenic MSH2 P43246 A831R 831 A R 0.962 Pathogenic MSH2 P43246 A831S 831 A S 0.454 Neutral MSH2 P43246 A831T 831 A T 0.744 Pathogenic MSH2 P43246 A831V 831 A V 0.914 Pathogenic MSH2 P43246 A831W 831 A W 0.98 Pathogenic MSH2 P43246 A831Y 831 A Y 0.966 Pathogenic MSH2 P43246 E832A 832 E A 0.812 Pathogenic MSH2 P43246 E832C 832 E C 0.758 Pathogenic MSH2 P43246 E832D 832 E D 0.41 Neutral MSH2 P43246 E832F 832 E F 0.964 Pathogenic MSH2 P43246 E832G 832 E G 0.382 Neutral MSH2 P43246 E832H 832 E H 0.796 Pathogenic MSH2 P43246 E832I 832 E I 0.58 Pathogenic MSH2 P43246 E832K 832 E K 0.276 Neutral MSH2 P43246 E832L 832 E L 0.972 Pathogenic MSH2 P43246 E832M 832 E M 0.91 Pathogenic MSH2 P43246 E832N 832 E N 0.77 Pathogenic MSH2 P43246 E832P 832 E P 0.934 Pathogenic MSH2 P43246 E832Q 832 E Q 0.188 Neutral MSH2 P43246 E832R 832 E R 0.354 Neutral MSH2 P43246 E832S 832 E S 0.304 Neutral MSH2 P43246 E832T 832 E T 0.86 Pathogenic MSH2 P43246 E832V 832 E V 0.446 Neutral MSH2 P43246 E832W 832 E W 0.978 Pathogenic MSH2 P43246 E832Y 832 E Y 0.958 Pathogenic MSH2 P43246 L833A 833 L A 0.566 Pathogenic MSH2 P43246 L833C 833 L C 0.132 Neutral MSH2 P43246 L833D 833 L D 0.886 Pathogenic MSH2 P43246 L833E 833 L E 0.872 Pathogenic MSH2 P43246 L833F 833 L F 0.454 Neutral MSH2 P43246 L833G 833 L G 0.788 Pathogenic MSH2 P43246 L833H 833 L H 0.822 Pathogenic MSH2 P43246 L833I 833 L I 0.22 Neutral MSH2 P43246 L833K 833 L K 0.742 Pathogenic MSH2 P43246 L833M 833 L M 0.178 Neutral MSH2 P43246 L833N 833 L N 0.752 Pathogenic MSH2 P43246 L833P 833 L P 0.986 Pathogenic MSH2 P43246 L833Q 833 L Q 0.624 Pathogenic MSH2 P43246 L833R 833 L R 0.99 Pathogenic MSH2 P43246 L833S 833 L S 0.596 Pathogenic MSH2 P43246 L833T 833 L T 0.578 Pathogenic MSH2 P43246 L833V 833 L V 0.084 Neutral MSH2 P43246 L833W 833 L W 0.83 Pathogenic MSH2 P43246 L833Y 833 L Y 0.906 Pathogenic MSH2 P43246 A834C 834 A C 0.584 Pathogenic MSH2 P43246 A834D 834 A D 0.922 Pathogenic MSH2 P43246 A834E 834 A E 0.902 Pathogenic MSH2 P43246 A834F 834 A F 0.966 Pathogenic MSH2 P43246 A834G 834 A G 0.752 Pathogenic MSH2 P43246 A834H 834 A H 0.886 Pathogenic MSH2 P43246 A834I 834 A I 0.956 Pathogenic MSH2 P43246 A834K 834 A K 0.94 Pathogenic MSH2 P43246 A834L 834 A L 0.98 Pathogenic MSH2 P43246 A834M 834 A M 0.864 Pathogenic MSH2 P43246 A834N 834 A N 0.846 Pathogenic MSH2 P43246 A834P 834 A P 0.968 Pathogenic MSH2 P43246 A834Q 834 A Q 0.566 Pathogenic MSH2 P43246 A834R 834 A R 0.96 Pathogenic MSH2 P43246 A834S 834 A S 0.226 Neutral MSH2 P43246 A834T 834 A T 0.264 Neutral 2 MSH2 P43246 A834V 834 A V 0.42 Neutral MSH2 P43246 A834W 834 A W 0.976 Pathogenic MSH2 P43246 A834Y 834 A Y 0.96 Pathogenic MSH2 P43246 N835A 835 N A 0.07 Neutral MSH2 P43246 N835C 835 N C 0.08 Neutral MSH2 P43246 N835D 835 N D 0.028 Neutral MSH2 P43246 N835E 835 N E 0.308 Neutral MSH2 P43246 N835F 835 N F 0.922 Pathogenic MSH2 P43246 N835G 835 N G 0.084 Neutral MSH2 P43246 N835H 835 N H 0.066 Neutral MSH2 P43246 N835I 835 N I 0.864 Pathogenic MSH2 P43246 N835K 835 N K 0.098 Neutral MSH2 P43246 N835L 835 N L 0.826 Pathogenic MSH2 P43246 N835M 835 N M 0.794 Pathogenic MSH2 P43246 N835P 835 N P 0.774 Pathogenic MSH2 P43246 N835Q 835 N Q 0.04 Neutral MSH2 P43246 N835R 835 N R 0.452 Neutral MSH2 P43246 N835S 835 N S 0.05 Neutral MSH2 P43246 N835T 835 N T 0.578 Pathogenic MSH2 P43246 N835V 835 N V 0.934 Pathogenic MSH2 P43246 N835W 835 N W 0.956 Pathogenic MSH2 P43246 N835Y 835 N Y 0.948 Pathogenic MSH2 P43246 F836A 836 F A 0.502 Pathogenic MSH2 P43246 F836C 836 F C 0.732 Pathogenic MSH2 P43246 F836D 836 F D 0.82 Pathogenic MSH2 P43246 F836E 836 F E 0.874 Pathogenic MSH2 P43246 F836G 836 F G 0.504 Pathogenic MSH2 P43246 F836H 836 F H 0.782 Pathogenic MSH2 P43246 F836I 836 F I 0.692 Pathogenic MSH2 P43246 F836K 836 F K 0.854 Pathogenic MSH2 P43246 F836L 836 F L 0.44 Neutral MSH2 P43246 F836M 836 F M 0.516 Pathogenic MSH2 P43246 F836N 836 F N 0.768 Pathogenic MSH2 P43246 F836P 836 F P 0.946 Pathogenic MSH2 P43246 F836Q 836 F Q 0.79 Pathogenic MSH2 P43246 F836R 836 F R 0.918 Pathogenic MSH2 P43246 F836S 836 F S 0.876 Pathogenic MSH2 P43246 F836T 836 F T 0.608 Pathogenic MSH2 P43246 F836V 836 F V 0.764 Pathogenic MSH2 P43246 F836W 836 F W 0.874 Pathogenic MSH2 P43246 F836Y 836 F Y 0.588 Pathogenic MSH2 P43246 P837A 837 P A 0.626 Pathogenic MSH2 P43246 P837C 837 P C 0.91 Pathogenic MSH2 P43246 P837D 837 P D 0.864 Pathogenic MSH2 P43246 P837E 837 P E 0.954 Pathogenic MSH2 P43246 P837F 837 P F 0.998 Pathogenic MSH2 P43246 P837G 837 P G 0.688 Pathogenic MSH2 P43246 P837H 837 P H 0.974 Pathogenic MSH2 P43246 P837I 837 P I 0.934 Pathogenic MSH2 P43246 P837K 837 P K 0.944 Pathogenic MSH2 P43246 P837L 837 P L 0.994 Pathogenic MSH2 P43246 P837M 837 P M 0.954 Pathogenic MSH2 P43246 P837N 837 P N 0.786 Pathogenic MSH2 P43246 P837Q 837 P Q 0.696 Pathogenic MSH2 P43246 P837R 837 P R 0.982 Pathogenic MSH2 P43246 P837S 837 P S 0.366 Neutral MSH2 P43246 P837T 837 P T 0.73 Pathogenic MSH2 P43246 P837V 837 P V 0.828 Pathogenic MSH2 P43246 P837W 837 P W 0.93 Pathogenic MSH2 P43246 P837Y 837 P Y 0.926 Pathogenic MSH2 P43246 K838A 838 K A 0.072 Neutral MSH2 P43246 K838C 838 K C 0.158 Neutral MSH2 P43246 K838D 838 K D 0.008 Neutral MSH2 P43246 K838E 838 K E 0.012 Neutral MSH2 P43246 K838F 838 K F 0.822 Pathogenic MSH2 P43246 K838G 838 K G 0.32 Neutral MSH2 P43246 K838H 838 K H 0.328 Neutral MSH2 P43246 K838I 838 K I 0.86 Pathogenic MSH2 P43246 K838L 838 K L 0.42 Neutral MSH2 P43246 K838M 838 K M 0.626 Pathogenic MSH2 P43246 K838N 838 K N 0.302 Neutral MSH2 P43246 K838P 838 K P 0.082 Neutral MSH2 P43246 K838Q 838 K Q 0.024 Neutral MSH2 P43246 K838R 838 K R 0.026 Neutral MSH2 P43246 K838S 838 K S 0.034 Neutral MSH2 P43246 K838T 838 K T 0.202 Neutral MSH2 P43246 K838V 838 K V 0.758 Pathogenic MSH2 P43246 K838W 838 K W 0.976 Pathogenic MSH2 P43246 K838Y 838 K Y 0.924 Pathogenic MSH2 P43246 H839A 839 H A 0.114 Neutral MSH2 P43246 H839C 839 H C 0.116 Neutral MSH2 P43246 H839D 839 H D 0.012 Neutral MSH2 P43246 H839E 839 H E 0.008 Neutral MSH2 P43246 H839F 839 H F 0.736 Pathogenic MSH2 P43246 H839G 839 H G 0.308 Neutral MSH2 P43246 H839I 839 H I 0.714 Pathogenic MSH2 P43246 H839K 839 H K 0.034 Neutral MSH2 P43246 H839L 839 H L 0.718 Pathogenic MSH2 P43246 H839M 839 H M 0.614 Pathogenic MSH2 P43246 H839N 839 H N 0.014 Neutral MSH2 P43246 H839P 839 H P 0.892 Pathogenic MSH2 P43246 H839Q 839 H Q 0.02 Neutral MSH2 P43246 H839R 839 H R 0.172 Neutral MSH2 P43246 H839S 839 H S 0.04 Neutral MSH2 P43246 H839T 839 H T 0.184 Neutral MSH2 P43246 H839V 839 H V 0.136 Neutral MSH2 P43246 H839W 839 H W 0.954 Pathogenic MSH2 P43246 H839Y 839 H Y 0.766 Pathogenic MSH2 P43246 N84A 84 N A 0.188 Neutral MSH2 P43246 N84C 84 N C 0.244 Neutral MSH2 P43246 N84D 84 N D 0.226 Neutral MSH2 P43246 N84E 84 N E 0.058 Neutral MSH2 P43246 N84F 84 N F 0.59 Pathogenic MSH2 P43246 N84G 84 N G 0.238 Neutral MSH2 P43246 N84H 84 N H 0.028 Neutral MSH2 P43246 N84I 84 N I 0.45 Neutral MSH2 P43246 N84K 84 N K 0.206 Neutral MSH2 P43246 N84L 84 N L 0.506 Pathogenic MSH2 P43246 N84M 84 N M 0.374 Neutral MSH2 P43246 N84P 84 N P 0.406 Neutral MSH2 P43246 N84Q 84 N Q 0.05 Neutral MSH2 P43246 N84R 84 N R 0.36 Neutral MSH2 P43246 N84S 84 N S 0.11 Neutral MSH2 P43246 N84T 84 N T 0.19 Neutral MSH2 P43246 N84V 84 N V 0.464 Neutral MSH2 P43246 N84W 84 N W 0.726 Pathogenic MSH2 P43246 N84Y 84 N Y 0.68 Pathogenic MSH2 P43246 V840A 840 V A 0.524 Pathogenic MSH2 P43246 V840C 840 V C 0.812 Pathogenic MSH2 P43246 V840D 840 V D 0.872 Pathogenic MSH2 P43246 V840E 840 V E 0.966 Pathogenic MSH2 P43246 V840F 840 V F 0.744 Pathogenic MSH2 P43246 V840G 840 V G 0.924 Pathogenic MSH2 P43246 V840H 840 V H 0.916 Pathogenic MSH2 P43246 V840I 840 V I 0.388 Neutral MSH2 P43246 V840K 840 V K 0.984 Pathogenic MSH2 P43246 V840L 840 V L 0.672 Pathogenic MSH2 P43246 V840M 840 V M 0.634 Pathogenic MSH2 P43246 V840N 840 V N 0.928 Pathogenic MSH2 P43246 V840P 840 V P 0.992 Pathogenic MSH2 P43246 V840Q 840 V Q 0.972 Pathogenic MSH2 P43246 V840R 840 V R 0.956 Pathogenic MSH2 P43246 V840S 840 V S 0.814 Pathogenic MSH2 P43246 V840T 840 V T 0.882 Pathogenic MSH2 P43246 V840W 840 V W 0.956 Pathogenic MSH2 P43246 V840Y 840 V Y 0.976 Pathogenic MSH2 P43246 I841A 841 I A 0.57 Pathogenic MSH2 P43246 I841C 841 I C 0.67 Pathogenic MSH2 P43246 I841D 841 I D 0.756 Pathogenic MSH2 P43246 I841E 841 I E 0.756 Pathogenic MSH2 P43246 I841F 841 I F 0.944 Pathogenic MSH2 P43246 I841G 841 I G 0.82 Pathogenic MSH2 P43246 I841H 841 I H 0.898 Pathogenic MSH2 P43246 I841K 841 I K 0.848 Pathogenic MSH2 P43246 I841L 841 I L 0.09 Neutral MSH2 P43246 I841M 841 I M 0.708 Pathogenic MSH2 P43246 I841N 841 I N 0.778 Pathogenic MSH2 P43246 I841P 841 I P 0.93 Pathogenic MSH2 P43246 I841Q 841 I Q 0.788 Pathogenic MSH2 P43246 I841R 841 I R 0.864 Pathogenic MSH2 P43246 I841S 841 I S 0.66 Pathogenic MSH2 P43246 I841T 841 I T 0.35 Neutral MSH2 P43246 I841V 841 I V 0.234 Neutral MSH2 P43246 I841W 841 I W 0.984 Pathogenic MSH2 P43246 I841Y 841 I Y 0.972 Pathogenic MSH2 P43246 E842A 842 E A 0.232 Neutral MSH2 P43246 E842C 842 E C 0.38 Neutral MSH2 P43246 E842D 842 E D 0.056 Neutral MSH2 P43246 E842F 842 E F 0.836 Pathogenic MSH2 P43246 E842G 842 E G 0.178 Neutral MSH2 P43246 E842H 842 E H 0.366 Neutral MSH2 P43246 E842I 842 E I 0.904 Pathogenic MSH2 P43246 E842K 842 E K 0.046 Neutral MSH2 P43246 E842L 842 E L 0.878 Pathogenic MSH2 P43246 E842M 842 E M 0.68 Pathogenic MSH2 P43246 E842N 842 E N 0.03 Neutral MSH2 P43246 E842P 842 E P 0.776 Pathogenic MSH2 P43246 E842Q 842 E Q 0.03 Neutral MSH2 P43246 E842R 842 E R 0.13 Neutral MSH2 P43246 E842S 842 E S 0.056 Neutral MSH2 P43246 E842T 842 E T 0.074 Neutral MSH2 P43246 E842V 842 E V 0.75 Pathogenic MSH2 P43246 E842W 842 E W 0.968 Pathogenic MSH2 P43246 E842Y 842 E Y 0.906 Pathogenic MSH2 P43246 C843A 843 C A 0.09 Neutral MSH2 P43246 C843D 843 C D 0.152 Neutral MSH2 P43246 C843E 843 C E 0.582 Pathogenic MSH2 P43246 C843F 843 C F 0.592 Pathogenic MSH2 P43246 C843G 843 C G 0.514 Pathogenic MSH2 P43246 C843H 843 C H 0.362 Neutral MSH2 P43246 C843I 843 C I 0.288 Neutral MSH2 P43246 C843K 843 C K 0.65 Pathogenic MSH2 P43246 C843L 843 C L 0.092 Neutral MSH2 P43246 C843M 843 C M 0.108 Neutral MSH2 P43246 C843N 843 C N 0.032 Neutral MSH2 P43246 C843P 843 C P 0.858 Pathogenic MSH2 P43246 C843Q 843 C Q 0.502 Pathogenic MSH2 P43246 C843R 843 C R 0.912 Pathogenic MSH2 P43246 C843S 843 C S 0.04 Neutral MSH2 P43246 C843T 843 C T 0.028 Neutral MSH2 P43246 C843V 843 C V 0.094 Neutral MSH2 P43246 C843W 843 C W 0.952 Pathogenic MSH2 P43246 C843Y 843 C Y 0.578 Pathogenic MSH2 P43246 A844C 844 A C 0.862 Pathogenic MSH2 P43246 A844D 844 A D 0.842 Pathogenic MSH2 P43246 A844E 844 A E 0.876 Pathogenic MSH2 P43246 A844F 844 A F 0.966 Pathogenic MSH2 P43246 A844G 844 A G 0.734 Pathogenic MSH2 P43246 A844H 844 A H 0.866 Pathogenic MSH2 P43246 A844I 844 A I 0.958 Pathogenic MSH2 P43246 A844K 844 A K 0.936 Pathogenic MSH2 P43246 A844L 844 A L 0.98 Pathogenic MSH2 P43246 A844M 844 A M 0.824 Pathogenic MSH2 P43246 A844N 844 A N 0.854 Pathogenic MSH2 P43246 A844P 844 A P 0.958 Pathogenic MSH2 P43246 A844Q 844 A Q 0.814 Pathogenic MSH2 P43246 A844R 844 A R 0.954 Pathogenic MSH2 P43246 A844S 844 A S 0.336 Neutral MSH2 P43246 A844T 844 A T 0.734 Pathogenic MSH2 P43246 A844V 844 A V 0.908 Pathogenic MSH2 P43246 A844W 844 A W 0.976 Pathogenic MSH2 P43246 A844Y 844 A Y 0.962 Pathogenic MSH2 P43246 K845A 845 K A 0.6 Pathogenic MSH2 P43246 K845C 845 K C 0.478 Neutral MSH2 P43246 K845D 845 K D 0.67 Pathogenic MSH2 P43246 K845E 845 K E 0.176 Neutral MSH2 P43246 K845F 845 K F 0.95 Pathogenic MSH2 P43246 K845G 845 K G 0.52 Pathogenic MSH2 P43246 K845H 845 K H 0.8 Pathogenic MSH2 P43246 K845I 845 K I 0.966 Pathogenic MSH2 P43246 K845L 845 K L 0.96 Pathogenic MSH2 P43246 K845M 845 K M 0.898 Pathogenic MSH2 P43246 K845N 845 K N 0.71 Pathogenic MSH2 P43246 K845P 845 K P 0.66 Pathogenic MSH2 P43246 K845Q 845 K Q 0.148 Neutral MSH2 P43246 K845R 845 K R 0.142 Neutral MSH2 P43246 K845S 845 K S 0.36 Neutral MSH2 P43246 K845T 845 K T 0.302 Neutral MSH2 P43246 K845V 845 K V 0.518 Pathogenic MSH2 P43246 K845W 845 K W 0.984 Pathogenic MSH2 P43246 K845Y 845 K Y 0.976 Pathogenic MSH2 P43246 Q846A 846 Q A 0.248 Neutral MSH2 P43246 Q846C 846 Q C 0.338 Neutral MSH2 P43246 Q846D 846 Q D 0.17 Neutral MSH2 P43246 Q846E 846 Q E 0.204 Neutral MSH2 P43246 Q846F 846 Q F 0.822 Pathogenic MSH2 P43246 Q846G 846 Q G 0.454 Neutral MSH2 P43246 Q846H 846 Q H 0.814 Pathogenic MSH2 P43246 Q846I 846 Q I 0.878 Pathogenic MSH2 P43246 Q846K 846 Q K 0.304 Neutral MSH2 P43246 Q846L 846 Q L 0.536 Pathogenic MSH2 P43246 Q846M 846 Q M 0.692 Pathogenic MSH2 P43246 Q846N 846 Q N 0.688 Pathogenic MSH2 P43246 Q846P 846 Q P 0.84 Pathogenic MSH2 P43246 Q846R 846 Q R 0.292 Neutral MSH2 P43246 Q846S 846 Q S 0.26 Neutral MSH2 P43246 Q846T 846 Q T 0.504 Pathogenic MSH2 P43246 Q846V 846 Q V 0.846 Pathogenic MSH2 P43246 Q846W 846 Q W 0.882 Pathogenic MSH2 P43246 Q846Y 846 Q Y 0.864 Pathogenic MSH2 P43246 K847A 847 K A 0.688 Pathogenic MSH2 P43246 K847C 847 K C 0.57 Pathogenic MSH2 P43246 K847D 847 K D 0.758 Pathogenic MSH2 P43246 K847E 847 K E 0.418 Neutral MSH2 P43246 K847F 847 K F 0.602 Pathogenic MSH2 P43246 K847G 847 K G 0.53 Pathogenic MSH2 P43246 K847H 847 K H 0.396 Neutral MSH2 P43246 K847I 847 K I 0.492 Neutral MSH2 P43246 K847L 847 K L 0.48 Neutral MSH2 P43246 K847M 847 K M 0.432 Neutral MSH2 P43246 K847N 847 K N 0.38 Neutral MSH2 P43246 K847P 847 K P 0.908 Pathogenic MSH2 P43246 K847Q 847 K Q 0.842 Pathogenic MSH2 P43246 K847R 847 K R 0.422 Neutral MSH2 P43246 K847S 847 K S 0.602 Pathogenic MSH2 P43246 K847T 847 K T 0.168 Neutral MSH2 P43246 K847V 847 K V 0.258 Neutral MSH2 P43246 K847W 847 K W 0.976 Pathogenic MSH2 P43246 K847Y 847 K Y 0.962 Pathogenic MSH2 P43246 A848C 848 A C 0.798 Pathogenic MSH2 P43246 A848D 848 A D 0.892 Pathogenic MSH2 P43246 A848E 848 A E 0.65 Pathogenic MSH2 P43246 A848F 848 A F 0.94 Pathogenic MSH2 P43246 A848G 848 A G 0.686 Pathogenic MSH2 P43246 A848H 848 A H 0.832 Pathogenic MSH2 P43246 A848I 848 A I 0.874 Pathogenic MSH2 P43246 A848K 848 A K 0.908 Pathogenic MSH2 P43246 A848L 848 A L 0.722 Pathogenic MSH2 P43246 A848M 848 A M 0.728 Pathogenic MSH2 P43246 A848N 848 A N 0.812 Pathogenic MSH2 P43246 A848P 848 A P 0.948 Pathogenic MSH2 P43246 A848Q 848 A Q 0.476 Neutral MSH2 P43246 A848R 848 A R 0.754 Pathogenic MSH2 P43246 A848S 848 A S 0.32 Neutral 1 MSH2 P43246 A848T 848 A T 0.658 Pathogenic MSH2 P43246 A848V 848 A V 0.49 Neutral MSH2 P43246 A848W 848 A W 0.95 Pathogenic MSH2 P43246 A848Y 848 A Y 0.698 Pathogenic MSH2 P43246 L849A 849 L A 0.058 Neutral MSH2 P43246 L849C 849 L C 0.338 Neutral MSH2 P43246 L849D 849 L D 0.088 Neutral MSH2 P43246 L849E 849 L E 0.082 Neutral MSH2 P43246 L849F 849 L F 0.784 Pathogenic MSH2 P43246 L849G 849 L G 0.54 Pathogenic MSH2 P43246 L849H 849 L H 0.186 Neutral MSH2 P43246 L849I 849 L I 0.5 Pathogenic MSH2 P43246 L849K 849 L K 0.06 Neutral MSH2 P43246 L849M 849 L M 0.444 Neutral MSH2 P43246 L849N 849 L N 0.092 Neutral MSH2 P43246 L849P 849 L P 0.9 Pathogenic MSH2 P43246 L849Q 849 L Q 0.058 Neutral MSH2 P43246 L849R 849 L R 0.63 Pathogenic MSH2 P43246 L849S 849 L S 0.056 Neutral MSH2 P43246 L849T 849 L T 0.102 Neutral MSH2 P43246 L849V 849 L V 0.472 Neutral MSH2 P43246 L849W 849 L W 0.868 Pathogenic MSH2 P43246 L849Y 849 L Y 0.866 Pathogenic MSH2 P43246 F85A 85 F A 0.132 Neutral MSH2 P43246 F85C 85 F C 0.218 Neutral MSH2 P43246 F85D 85 F D 0.772 Pathogenic MSH2 P43246 F85E 85 F E 0.856 Pathogenic MSH2 P43246 F85G 85 F G 0.298 Neutral MSH2 P43246 F85H 85 F H 0.634 Pathogenic MSH2 P43246 F85I 85 F I 0.218 Neutral MSH2 P43246 F85K 85 F K 0.838 Pathogenic MSH2 P43246 F85L 85 F L 0.104 Neutral MSH2 P43246 F85M 85 F M 0.274 Neutral MSH2 P43246 F85N 85 F N 0.692 Pathogenic MSH2 P43246 F85P 85 F P 0.94 Pathogenic MSH2 P43246 F85Q 85 F Q 0.724 Pathogenic MSH2 P43246 F85R 85 F R 0.908 Pathogenic MSH2 P43246 F85S 85 F S 0.758 Pathogenic MSH2 P43246 F85T 85 F T 0.158 Neutral MSH2 P43246 F85V 85 F V 0.182 Neutral MSH2 P43246 F85W 85 F W 0.944 Pathogenic MSH2 P43246 F85Y 85 F Y 0.266 Neutral MSH2 P43246 E850A 850 E A 0.802 Pathogenic MSH2 P43246 E850C 850 E C 0.746 Pathogenic MSH2 P43246 E850D 850 E D 0.272 Neutral MSH2 P43246 E850F 850 E F 0.834 Pathogenic MSH2 P43246 E850G 850 E G 0.344 Neutral MSH2 P43246 E850H 850 E H 0.706 Pathogenic MSH2 P43246 E850I 850 E I 0.608 Pathogenic MSH2 P43246 E850K 850 E K 0.496 Neutral MSH2 P43246 E850L 850 E L 0.962 Pathogenic MSH2 P43246 E850M 850 E M 0.894 Pathogenic MSH2 P43246 E850N 850 E N 0.358 Neutral MSH2 P43246 E850P 850 E P 0.932 Pathogenic MSH2 P43246 E850Q 850 E Q 0.254 Neutral MSH2 P43246 E850R 850 E R 0.926 Pathogenic MSH2 P43246 E850S 850 E S 0.89 Pathogenic MSH2 P43246 E850T 850 E T 0.37 Neutral MSH2 P43246 E850V 850 E V 0.914 Pathogenic MSH2 P43246 E850W 850 E W 0.974 Pathogenic MSH2 P43246 E850Y 850 E Y 0.954 Pathogenic MSH2 P43246 L851A 851 L A 0.714 Pathogenic MSH2 P43246 L851C 851 L C 0.246 Neutral MSH2 P43246 L851D 851 L D 0.9 Pathogenic MSH2 P43246 L851E 851 L E 0.882 Pathogenic MSH2 P43246 L851F 851 L F 0.49 Neutral MSH2 P43246 L851G 851 L G 0.87 Pathogenic MSH2 P43246 L851H 851 L H 0.906 Pathogenic MSH2 P43246 L851I 851 L I 0.534 Pathogenic MSH2 P43246 L851K 851 L K 0.71 Pathogenic MSH2 P43246 L851M 851 L M 0.356 Neutral MSH2 P43246 L851N 851 L N 0.81 Pathogenic MSH2 P43246 L851P 851 L P 0.978 Pathogenic MSH2 P43246 L851Q 851 L Q 0.764 Pathogenic MSH2 P43246 L851R 851 L R 0.982 Pathogenic MSH2 P43246 L851S 851 L S 0.698 Pathogenic MSH2 P43246 L851T 851 L T 0.614 Pathogenic MSH2 P43246 L851V 851 L V 0.196 Neutral MSH2 P43246 L851W 851 L W 0.862 Pathogenic MSH2 P43246 L851Y 851 L Y 0.878 Pathogenic MSH2 P43246 E852A 852 E A 0.81 Pathogenic MSH2 P43246 E852C 852 E C 0.764 Pathogenic MSH2 P43246 E852D 852 E D 0.398 Neutral MSH2 P43246 E852F 852 E F 0.962 Pathogenic MSH2 P43246 E852G 852 E G 0.332 Neutral MSH2 P43246 E852H 852 E H 0.744 Pathogenic MSH2 P43246 E852I 852 E I 0.984 Pathogenic MSH2 P43246 E852K 852 E K 0.916 Pathogenic MSH2 P43246 E852L 852 E L 0.976 Pathogenic MSH2 P43246 E852M 852 E M 0.912 Pathogenic MSH2 P43246 E852N 852 E N 0.782 Pathogenic MSH2 P43246 E852P 852 E P 0.94 Pathogenic MSH2 P43246 E852Q 852 E Q 0.854 Pathogenic MSH2 P43246 E852R 852 E R 0.734 Pathogenic MSH2 P43246 E852S 852 E S 0.9 Pathogenic MSH2 P43246 E852T 852 E T 0.848 Pathogenic MSH2 P43246 E852V 852 E V 0.922 Pathogenic MSH2 P43246 E852W 852 E W 0.93 Pathogenic MSH2 P43246 E852Y 852 E Y 0.96 Pathogenic MSH2 P43246 E853A 853 E A 0.394 Neutral MSH2 P43246 E853C 853 E C 0.308 Neutral MSH2 P43246 E853D 853 E D 0.09 Neutral MSH2 P43246 E853F 853 E F 0.962 Pathogenic MSH2 P43246 E853G 853 E G 0.144 Neutral MSH2 P43246 E853H 853 E H 0.858 Pathogenic MSH2 P43246 E853I 853 E I 0.982 Pathogenic MSH2 P43246 E853K 853 E K 0.494 Neutral MSH2 P43246 E853L 853 E L 0.74 Pathogenic MSH2 P43246 E853M 853 E M 0.69 Pathogenic MSH2 P43246 E853N 853 E N 0.122 Neutral MSH2 P43246 E853P 853 E P 0.93 Pathogenic MSH2 P43246 E853Q 853 E Q 0.096 Neutral MSH2 P43246 E853R 853 E R 0.518 Pathogenic MSH2 P43246 E853S 853 E S 0.154 Neutral MSH2 P43246 E853T 853 E T 0.416 Neutral MSH2 P43246 E853V 853 E V 0.92 Pathogenic MSH2 P43246 E853W 853 E W 0.986 Pathogenic MSH2 P43246 E853Y 853 E Y 0.966 Pathogenic MSH2 P43246 F854A 854 F A 0.208 Neutral MSH2 P43246 F854C 854 F C 0.162 Neutral MSH2 P43246 F854D 854 F D 0.436 Neutral MSH2 P43246 F854E 854 F E 0.87 Pathogenic MSH2 P43246 F854G 854 F G 0.484 Neutral MSH2 P43246 F854H 854 F H 0.116 Neutral MSH2 P43246 F854I 854 F I 0.122 Neutral MSH2 P43246 F854K 854 F K 0.482 Neutral MSH2 P43246 F854L 854 F L 0.082 Neutral MSH2 P43246 F854M 854 F M 0.66 Pathogenic MSH2 P43246 F854N 854 F N 0.232 Neutral MSH2 P43246 F854P 854 F P 0.942 Pathogenic MSH2 P43246 F854Q 854 F Q 0.45 Neutral MSH2 P43246 F854R 854 F R 0.92 Pathogenic MSH2 P43246 F854S 854 F S 0.236 Neutral MSH2 P43246 F854T 854 F T 0.162 Neutral MSH2 P43246 F854V 854 F V 0.832 Pathogenic MSH2 P43246 F854W 854 F W 0.938 Pathogenic MSH2 P43246 F854Y 854 F Y 0.262 Neutral MSH2 P43246 Q855A 855 Q A 0.06 Neutral MSH2 P43246 Q855C 855 Q C 0.146 Neutral MSH2 P43246 Q855D 855 Q D 0.126 Neutral MSH2 P43246 Q855E 855 Q E 0.01 Neutral MSH2 P43246 Q855F 855 Q F 0.452 Neutral MSH2 P43246 Q855G 855 Q G 0.054 Neutral MSH2 P43246 Q855H 855 Q H 0.228 Neutral MSH2 P43246 Q855I 855 Q I 0.578 Pathogenic MSH2 P43246 Q855K 855 Q K 0.03 Neutral MSH2 P43246 Q855L 855 Q L 0.302 Neutral MSH2 P43246 Q855M 855 Q M 0.358 Neutral MSH2 P43246 Q855N 855 Q N 0.03 Neutral MSH2 P43246 Q855P 855 Q P 0.502 Pathogenic MSH2 P43246 Q855R 855 Q R 0.14 Neutral MSH2 P43246 Q855S 855 Q S 0.052 Neutral MSH2 P43246 Q855T 855 Q T 0.006 Neutral MSH2 P43246 Q855V 855 Q V 0.458 Neutral MSH2 P43246 Q855W 855 Q W 0.776 Pathogenic MSH2 P43246 Q855Y 855 Q Y 0.542 Pathogenic MSH2 P43246 Y856A 856 Y A 0.046 Neutral MSH2 P43246 Y856C 856 Y C 0.132 Neutral MSH2 P43246 Y856D 856 Y D 0.032 Neutral MSH2 P43246 Y856E 856 Y E 0.032 Neutral MSH2 P43246 Y856F 856 Y F 0.036 Neutral MSH2 P43246 Y856G 856 Y G 0.098 Neutral MSH2 P43246 Y856H 856 Y H 0.002 Neutral MSH2 P43246 Y856I 856 Y I 0.094 Neutral MSH2 P43246 Y856K 856 Y K 0.024 Neutral MSH2 P43246 Y856L 856 Y L 0.04 Neutral MSH2 P43246 Y856M 856 Y M 0.076 Neutral MSH2 P43246 Y856N 856 Y N 0.07 Neutral MSH2 P43246 Y856P 856 Y P 0.064 Neutral MSH2 P43246 Y856Q 856 Y Q 0.122 Neutral MSH2 P43246 Y856R 856 Y R 0.142 Neutral MSH2 P43246 Y856S 856 Y S 0.096 Neutral MSH2 P43246 Y856T 856 Y T 0.052 Neutral MSH2 P43246 Y856V 856 Y V 0.03 Neutral MSH2 P43246 Y856W 856 Y W 0.048 Neutral MSH2 P43246 I857A 857 I A 0.006 Neutral MSH2 P43246 I857C 857 I C 0.09 Neutral MSH2 P43246 I857D 857 I D 0.166 Neutral MSH2 P43246 I857E 857 I E 0.028 Neutral MSH2 P43246 I857F 857 I F 0.088 Neutral MSH2 P43246 I857G 857 I G 0.206 Neutral MSH2 P43246 I857H 857 I H 0.08 Neutral MSH2 P43246 I857K 857 I K 0.068 Neutral MSH2 P43246 I857L 857 I L 0.058 Neutral MSH2 P43246 I857M 857 I M 0.112 Neutral MSH2 P43246 I857N 857 I N 0.234 Neutral MSH2 P43246 I857P 857 I P 0.064 Neutral MSH2 P43246 I857Q 857 I Q 0.138 Neutral MSH2 P43246 I857R 857 I R 0.232 Neutral MSH2 P43246 I857S 857 I S 0.072 Neutral MSH2 P43246 I857T 857 I T 0.092 Neutral MSH2 P43246 I857V 857 I V 0 Neutral MSH2 P43246 I857W 857 I W 0.344 Neutral MSH2 P43246 I857Y 857 I Y 0.32 Neutral MSH2 P43246 G858A 858 G A 0.004 Neutral MSH2 P43246 G858C 858 G C 0.21 Neutral MSH2 P43246 G858D 858 G D 0.306 Neutral MSH2 P43246 G858E 858 G E 0.252 Neutral MSH2 P43246 G858F 858 G F 0.59 Pathogenic MSH2 P43246 G858H 858 G H 0.464 Neutral MSH2 P43246 G858I 858 G I 0.508 Pathogenic MSH2 P43246 G858K 858 G K 0.452 Neutral MSH2 P43246 G858L 858 G L 0.508 Pathogenic MSH2 P43246 G858M 858 G M 0.438 Neutral MSH2 P43246 G858N 858 G N 0.236 Neutral MSH2 P43246 G858P 858 G P 0.476 Neutral MSH2 P43246 G858Q 858 G Q 0.334 Neutral MSH2 P43246 G858R 858 G R 0.384 Neutral MSH2 P43246 G858S 858 G S 0.022 Neutral MSH2 P43246 G858T 858 G T 0.282 Neutral MSH2 P43246 G858V 858 G V 0.4 Neutral MSH2 P43246 G858W 858 G W 0.588 Pathogenic MSH2 P43246 G858Y 858 G Y 0.568 Pathogenic MSH2 P43246 E859A 859 E A 0.066 Neutral MSH2 P43246 E859C 859 E C 0.068 Neutral MSH2 P43246 E859D 859 E D 0.004 Neutral MSH2 P43246 E859F 859 E F 0.272 Neutral MSH2 P43246 E859G 859 E G 0 Neutral MSH2 P43246 E859H 859 E H 0.104 Neutral MSH2 P43246 E859I 859 E I 0.254 Neutral MSH2 P43246 E859K 859 E K 0.002 Neutral MSH2 P43246 E859L 859 E L 0.286 Neutral MSH2 P43246 E859M 859 E M 0.164 Neutral MSH2 P43246 E859N 859 E N 0.002 Neutral MSH2 P43246 E859P 859 E P 0.3 Neutral MSH2 P43246 E859Q 859 E Q 0.056 Neutral MSH2 P43246 E859R 859 E R 0.016 Neutral MSH2 P43246 E859S 859 E S 0.014 Neutral MSH2 P43246 E859T 859 E T 0.006 Neutral MSH2 P43246 E859V 859 E V 0.142 Neutral MSH2 P43246 E859W 859 E W 0.43 Neutral MSH2 P43246 E859Y 859 E Y 0.398 Neutral MSH2 P43246 E86A 86 E A 0.328 Neutral MSH2 P43246 E86C 86 E C 0.502 Pathogenic MSH2 P43246 E86D 86 E D 0.268 Neutral MSH2 P43246 E86F 86 E F 0.886 Pathogenic MSH2 P43246 E86G 86 E G 0.15 Neutral MSH2 P43246 E86H 86 E H 0.308 Neutral MSH2 P43246 E86I 86 E I 0.354 Neutral MSH2 P43246 E86K 86 E K 0.038 Neutral MSH2 P43246 E86L 86 E L 0.904 Pathogenic MSH2 P43246 E86M 86 E M 0.636 Pathogenic MSH2 P43246 E86N 86 E N 0.036 Neutral MSH2 P43246 E86P 86 E P 0.734 Pathogenic MSH2 P43246 E86Q 86 E Q 0.018 Neutral MSH2 P43246 E86R 86 E R 0.14 Neutral MSH2 P43246 E86S 86 E S 0.04 Neutral MSH2 P43246 E86T 86 E T 0.232 Neutral MSH2 P43246 E86V 86 E V 0.218 Neutral MSH2 P43246 E86W 86 E W 0.964 Pathogenic MSH2 P43246 E86Y 86 E Y 0.922 Pathogenic MSH2 P43246 S860A 860 S A 0.01 Neutral MSH2 P43246 S860C 860 S C 0.032 Neutral MSH2 P43246 S860D 860 S D 0.002 Neutral MSH2 P43246 S860E 860 S E 0.138 Neutral MSH2 P43246 S860F 860 S F 0.266 Neutral MSH2 P43246 S860G 860 S G 0.002 Neutral MSH2 P43246 S860H 860 S H 0.238 Neutral MSH2 P43246 S860I 860 S I 0.124 Neutral MSH2 P43246 S860K 860 S K 0.14 Neutral MSH2 P43246 S860L 860 S L 0.032 Neutral 2 MSH2 P43246 S860M 860 S M 0.332 Neutral MSH2 P43246 S860N 860 S N 0.018 Neutral MSH2 P43246 S860P 860 S P 0.056 Neutral MSH2 P43246 S860Q 860 S Q 0.158 Neutral MSH2 P43246 S860R 860 S R 0.17 Neutral MSH2 P43246 S860T 860 S T 0.176 Neutral MSH2 P43246 S860V 860 S V 0.032 Neutral MSH2 P43246 S860W 860 S W 0.49 Neutral MSH2 P43246 S860Y 860 S Y 0.448 Neutral MSH2 P43246 Q861A 861 Q A 0.138 Neutral MSH2 P43246 Q861C 861 Q C 0.082 Neutral MSH2 P43246 Q861D 861 Q D 0 Neutral MSH2 P43246 Q861E 861 Q E 0.008 Neutral MSH2 P43246 Q861F 861 Q F 0.26 Neutral MSH2 P43246 Q861G 861 Q G 0.03 Neutral MSH2 P43246 Q861H 861 Q H 0.214 Neutral MSH2 P43246 Q861I 861 Q I 0.278 Neutral MSH2 P43246 Q861K 861 Q K 0.022 Neutral MSH2 P43246 Q861L 861 Q L 0.146 Neutral MSH2 P43246 Q861M 861 Q M 0.21 Neutral MSH2 P43246 Q861N 861 Q N 0.094 Neutral MSH2 P43246 Q861P 861 Q P 0.238 Neutral MSH2 P43246 Q861R 861 Q R 0.002 Neutral MSH2 P43246 Q861S 861 Q S 0.036 Neutral MSH2 P43246 Q861T 861 Q T 0.064 Neutral MSH2 P43246 Q861V 861 Q V 0.036 Neutral MSH2 P43246 Q861W 861 Q W 0.432 Neutral MSH2 P43246 Q861Y 861 Q Y 0.452 Neutral MSH2 P43246 G862A 862 G A 0.002 Neutral MSH2 P43246 G862C 862 G C 0.14 Neutral MSH2 P43246 G862D 862 G D 0.134 Neutral MSH2 P43246 G862E 862 G E 0.19 Neutral MSH2 P43246 G862F 862 G F 0.478 Neutral MSH2 P43246 G862H 862 G H 0.37 Neutral MSH2 P43246 G862I 862 G I 0.412 Neutral MSH2 P43246 G862K 862 G K 0.284 Neutral MSH2 P43246 G862L 862 G L 0.37 Neutral MSH2 P43246 G862M 862 G M 0.422 Neutral MSH2 P43246 G862N 862 G N 0.162 Neutral MSH2 P43246 G862P 862 G P 0.442 Neutral MSH2 P43246 G862Q 862 G Q 0.194 Neutral MSH2 P43246 G862R 862 G R 0.468 Neutral MSH2 P43246 G862S 862 G S 0.016 Neutral MSH2 P43246 G862T 862 G T 0.252 Neutral MSH2 P43246 G862V 862 G V 0.304 Neutral MSH2 P43246 G862W 862 G W 0.488 Neutral MSH2 P43246 G862Y 862 G Y 0.5 Pathogenic MSH2 P43246 Y863A 863 Y A 0.046 Neutral MSH2 P43246 Y863C 863 Y C 0.052 Neutral MSH2 P43246 Y863D 863 Y D 0.032 Neutral MSH2 P43246 Y863E 863 Y E 0.032 Neutral MSH2 P43246 Y863F 863 Y F 0.01 Neutral MSH2 P43246 Y863G 863 Y G 0.098 Neutral MSH2 P43246 Y863H 863 Y H 0.002 Neutral MSH2 P43246 Y863I 863 Y I 0.1 Neutral MSH2 P43246 Y863K 863 Y K 0.024 Neutral MSH2 P43246 Y863L 863 Y L 0.012 Neutral MSH2 P43246 Y863M 863 Y M 0.07 Neutral MSH2 P43246 Y863N 863 Y N 0.144 Neutral MSH2 P43246 Y863P 863 Y P 0.092 Neutral MSH2 P43246 Y863Q 863 Y Q 0.066 Neutral MSH2 P43246 Y863R 863 Y R 0.046 Neutral MSH2 P43246 Y863S 863 Y S 0.096 Neutral MSH2 P43246 Y863T 863 Y T 0.052 Neutral MSH2 P43246 Y863V 863 Y V 0.03 Neutral MSH2 P43246 Y863W 863 Y W 0.048 Neutral MSH2 P43246 D864A 864 D A 0.028 Neutral MSH2 P43246 D864C 864 D C 0.25 Neutral MSH2 P43246 D864E 864 D E 0.018 Neutral MSH2 P43246 D864F 864 D F 0.612 Pathogenic MSH2 P43246 D864G 864 D G 0.026 Neutral MSH2 P43246 D864H 864 D H 0.238 Neutral MSH2 P43246 D864I 864 D I 0.42 Neutral MSH2 P43246 D864K 864 D K 0.026 Neutral MSH2 P43246 D864L 864 D L 0.414 Neutral MSH2 P43246 D864M 864 D M 0.322 Neutral MSH2 P43246 D864N 864 D N 0.004 Neutral MSH2 P43246 D864P 864 D P 0.062 Neutral MSH2 P43246 D864Q 864 D Q 0.022 Neutral MSH2 P43246 D864R 864 D R 0.24 Neutral MSH2 P43246 D864S 864 D S 0.008 Neutral MSH2 P43246 D864T 864 D T 0.13 Neutral MSH2 P43246 D864V 864 D V 0.384 Neutral MSH2 P43246 D864W 864 D W 0.694 Pathogenic MSH2 P43246 D864Y 864 D Y 0.668 Pathogenic MSH2 P43246 I865A 865 I A 0.006 Neutral MSH2 P43246 I865C 865 I C 0.09 Neutral MSH2 P43246 I865D 865 I D 0.028 Neutral MSH2 P43246 I865E 865 I E 0.03 Neutral MSH2 P43246 I865F 865 I F 0.144 Neutral MSH2 P43246 I865G 865 I G 0.106 Neutral MSH2 P43246 I865H 865 I H 0.008 Neutral MSH2 P43246 I865K 865 I K 0.042 Neutral MSH2 P43246 I865L 865 I L 0 Neutral MSH2 P43246 I865M 865 I M 0.036 Neutral MSH2 P43246 I865N 865 I N 0.098 Neutral MSH2 P43246 I865P 865 I P 0.186 Neutral MSH2 P43246 I865Q 865 I Q 0.108 Neutral MSH2 P43246 I865R 865 I R 0.244 Neutral MSH2 P43246 I865S 865 I S 0.072 Neutral MSH2 P43246 I865T 865 I T 0.002 Neutral MSH2 P43246 I865V 865 I V 0.122 Neutral MSH2 P43246 I865W 865 I W 0.344 Neutral MSH2 P43246 I865Y 865 I Y 0.29 Neutral MSH2 P43246 M866A 866 M A 0.046 Neutral MSH2 P43246 M866C 866 M C 0.042 Neutral MSH2 P43246 M866D 866 M D 0.058 Neutral MSH2 P43246 M866E 866 M E 0.008 Neutral MSH2 P43246 M866F 866 M F 0.034 Neutral MSH2 P43246 M866G 866 M G 0.038 Neutral MSH2 P43246 M866H 866 M H 0.026 Neutral MSH2 P43246 M866I 866 M I 0.016 Neutral MSH2 P43246 M866K 866 M K 0.046 Neutral MSH2 P43246 M866L 866 M L 0.004 Neutral MSH2 P43246 M866N 866 M N 0.186 Neutral MSH2 P43246 M866P 866 M P 0.062 Neutral MSH2 P43246 M866Q 866 M Q 0.024 Neutral MSH2 P43246 M866R 866 M R 0.122 Neutral MSH2 P43246 M866S 866 M S 0.012 Neutral MSH2 P43246 M866T 866 M T 0.008 Neutral MSH2 P43246 M866V 866 M V 0.068 Neutral MSH2 P43246 M866W 866 M W 0.422 Neutral MSH2 P43246 M866Y 866 M Y 0.348 Neutral MSH2 P43246 E867A 867 E A 0.066 Neutral MSH2 P43246 E867C 867 E C 0.068 Neutral MSH2 P43246 E867D 867 E D 0 Neutral MSH2 P43246 E867F 867 E F 0.07 Neutral MSH2 P43246 E867G 867 E G 0 Neutral MSH2 P43246 E867H 867 E H 0.096 Neutral MSH2 P43246 E867I 867 E I 0.144 Neutral MSH2 P43246 E867K 867 E K 0.002 Neutral MSH2 P43246 E867L 867 E L 0.308 Neutral MSH2 P43246 E867M 867 E M 0.172 Neutral MSH2 P43246 E867N 867 E N 0.002 Neutral MSH2 P43246 E867P 867 E P 0.302 Neutral MSH2 P43246 E867Q 867 E Q 0.018 Neutral MSH2 P43246 E867R 867 E R 0.038 Neutral MSH2 P43246 E867S 867 E S 0.17 Neutral MSH2 P43246 E867T 867 E T 0.022 Neutral MSH2 P43246 E867V 867 E V 0.148 Neutral MSH2 P43246 E867W 867 E W 0.478 Neutral MSH2 P43246 E867Y 867 E Y 0.38 Neutral MSH2 P43246 P868A 868 P A 0.048 Neutral MSH2 P43246 P868C 868 P C 0.24 Neutral MSH2 P43246 P868D 868 P D 0.044 Neutral MSH2 P43246 P868E 868 P E 0.086 Neutral MSH2 P43246 P868F 868 P F 0.518 Pathogenic MSH2 P43246 P868G 868 P G 0.02 Neutral MSH2 P43246 P868H 868 P H 0.44 Neutral MSH2 P43246 P868I 868 P I 0.216 Neutral MSH2 P43246 P868K 868 P K 0.084 Neutral MSH2 P43246 P868L 868 P L 0.056 Neutral MSH2 P43246 P868M 868 P M 0.342 Neutral MSH2 P43246 P868N 868 P N 0.036 Neutral MSH2 P43246 P868Q 868 P Q 0.306 Neutral MSH2 P43246 P868R 868 P R 0.534 Pathogenic MSH2 P43246 P868S 868 P S 0.034 Neutral MSH2 P43246 P868T 868 P T 0.026 Neutral MSH2 P43246 P868V 868 P V 0.26 Neutral MSH2 P43246 P868W 868 P W 0.612 Pathogenic MSH2 P43246 P868Y 868 P Y 0.506 Pathogenic MSH2 P43246 A869C 869 A C 0.22 Neutral MSH2 P43246 A869D 869 A D 0.36 Neutral MSH2 P43246 A869E 869 A E 0.326 Neutral MSH2 P43246 A869F 869 A F 0.54 Pathogenic MSH2 P43246 A869G 869 A G 0.004 Neutral MSH2 P43246 A869H 869 A H 0.366 Neutral MSH2 P43246 A869I 869 A I 0.442 Neutral MSH2 P43246 A869K 869 A K 0.298 Neutral MSH2 P43246 A869L 869 A L 0.348 Neutral MSH2 P43246 A869M 869 A M 0.308 Neutral MSH2 P43246 A869N 869 A N 0.362 Neutral MSH2 P43246 A869P 869 A P 0.048 Neutral MSH2 P43246 A869Q 869 A Q 0.292 Neutral MSH2 P43246 A869R 869 A R 0.432 Neutral MSH2 P43246 A869S 869 A S 0.01 Neutral MSH2 P43246 A869T 869 A T 0.018 Neutral MSH2 P43246 A869V 869 A V 0.046 Neutral MSH2 P43246 A869W 869 A W 0.572 Pathogenic MSH2 P43246 A869Y 869 A Y 0.57 Pathogenic MSH2 P43246 S87A 87 S A 0.09 Neutral MSH2 P43246 S87C 87 S C 0.368 Neutral MSH2 P43246 S87D 87 S D 0.332 Neutral MSH2 P43246 S87E 87 S E 0.56 Pathogenic MSH2 P43246 S87F 87 S F 0.83 Pathogenic MSH2 P43246 S87G 87 S G 0.064 Neutral MSH2 P43246 S87H 87 S H 0.744 Pathogenic MSH2 P43246 S87I 87 S I 0.362 Neutral MSH2 P43246 S87K 87 S K 0.556 Pathogenic MSH2 P43246 S87L 87 S L 0.188 Neutral MSH2 P43246 S87M 87 S M 0.586 Pathogenic MSH2 P43246 S87N 87 S N 0.052 Neutral MSH2 P43246 S87P 87 S P 0.568 Pathogenic MSH2 P43246 S87Q 87 S Q 0.444 Neutral MSH2 P43246 S87R 87 S R 0.666 Pathogenic MSH2 P43246 S87T 87 S T 0.078 Neutral MSH2 P43246 S87V 87 S V 0.478 Neutral MSH2 P43246 S87W 87 S W 0.93 Pathogenic MSH2 P43246 S87Y 87 S Y 0.904 Pathogenic MSH2 P43246 A870C 870 A C 0.272 Neutral MSH2 P43246 A870D 870 A D 0.378 Neutral MSH2 P43246 A870E 870 A E 0.322 Neutral MSH2 P43246 A870F 870 A F 0.572 Pathogenic MSH2 P43246 A870G 870 A G 0.024 Neutral MSH2 P43246 A870H 870 A H 0.384 Neutral MSH2 P43246 A870I 870 A I 0.458 Neutral MSH2 P43246 A870K 870 A K 0.3 Neutral MSH2 P43246 A870L 870 A L 0.356 Neutral MSH2 P43246 A870M 870 A M 0.318 Neutral MSH2 P43246 A870N 870 A N 0.362 Neutral MSH2 P43246 A870P 870 A P 0.09 Neutral MSH2 P43246 A870Q 870 A Q 0.366 Neutral MSH2 P43246 A870R 870 A R 0.322 Neutral MSH2 P43246 A870S 870 A S 0.006 Neutral MSH2 P43246 A870T 870 A T 0.018 Neutral MSH2 P43246 A870V 870 A V 0.048 Neutral MSH2 P43246 A870W 870 A W 0.588 Pathogenic MSH2 P43246 A870Y 870 A Y 0.592 Pathogenic MSH2 P43246 K871A 871 K A 0.114 Neutral MSH2 P43246 K871C 871 K C 0.18 Neutral MSH2 P43246 K871D 871 K D 0.016 Neutral MSH2 P43246 K871E 871 K E 0.014 Neutral MSH2 P43246 K871F 871 K F 0.692 Pathogenic MSH2 P43246 K871G 871 K G 0.09 Neutral MSH2 P43246 K871H 871 K H 0.254 Neutral MSH2 P43246 K871I 871 K I 0.74 Pathogenic MSH2 P43246 K871L 871 K L 0.636 Pathogenic MSH2 P43246 K871M 871 K M 0.518 Pathogenic MSH2 P43246 K871N 871 K N 0.22 Neutral MSH2 P43246 K871P 871 K P 0.352 Neutral MSH2 P43246 K871Q 871 K Q 0.024 Neutral MSH2 P43246 K871R 871 K R 0.016 Neutral MSH2 P43246 K871S 871 K S 0.038 Neutral MSH2 P43246 K871T 871 K T 0.086 Neutral MSH2 P43246 K871V 871 K V 0.684 Pathogenic MSH2 P43246 K871W 871 K W 0.904 Pathogenic MSH2 P43246 K871Y 871 K Y 0.836 Pathogenic MSH2 P43246 K872A 872 K A 0.034 Neutral MSH2 P43246 K872C 872 K C 0.078 Neutral MSH2 P43246 K872D 872 K D 0.016 Neutral MSH2 P43246 K872E 872 K E 0.016 Neutral MSH2 P43246 K872F 872 K F 0.106 Neutral MSH2 P43246 K872G 872 K G 0.204 Neutral MSH2 P43246 K872H 872 K H 0.054 Neutral MSH2 P43246 K872I 872 K I 0.228 Neutral MSH2 P43246 K872L 872 K L 0.048 Neutral MSH2 P43246 K872M 872 K M 0.28 Neutral MSH2 P43246 K872N 872 K N 0.13 Neutral MSH2 P43246 K872P 872 K P 0.406 Neutral MSH2 P43246 K872Q 872 K Q 0.138 Neutral MSH2 P43246 K872R 872 K R 0.014 Neutral MSH2 P43246 K872S 872 K S 0.126 Neutral MSH2 P43246 K872T 872 K T 0.286 Neutral MSH2 P43246 K872V 872 K V 0.342 Neutral MSH2 P43246 K872W 872 K W 0.706 Pathogenic MSH2 P43246 K872Y 872 K Y 0.202 Neutral MSH2 P43246 C873A 873 C A 0.028 Neutral MSH2 P43246 C873D 873 C D 0.074 Neutral MSH2 P43246 C873E 873 C E 0.068 Neutral MSH2 P43246 C873F 873 C F 0.428 Neutral MSH2 P43246 C873G 873 C G 0.016 Neutral MSH2 P43246 C873H 873 C H 0.372 Neutral MSH2 P43246 C873I 873 C I 0.094 Neutral MSH2 P43246 C873K 873 C K 0.034 Neutral MSH2 P43246 C873L 873 C L 0.2 Neutral MSH2 P43246 C873M 873 C M 0.296 Neutral MSH2 P43246 C873N 873 C N 0.04 Neutral MSH2 P43246 C873P 873 C P 0.046 Neutral MSH2 P43246 C873Q 873 C Q 0.224 Neutral MSH2 P43246 C873R 873 C R 0.308 Neutral MSH2 P43246 C873S 873 C S 0.014 Neutral MSH2 P43246 C873T 873 C T 0.072 Neutral MSH2 P43246 C873V 873 C V 0.132 Neutral MSH2 P43246 C873W 873 C W 0.74 Pathogenic MSH2 P43246 C873Y 873 C Y 0.708 Pathogenic MSH2 P43246 Y874A 874 Y A 0.058 Neutral MSH2 P43246 Y874C 874 Y C 0.064 Neutral MSH2 P43246 Y874D 874 Y D 0.046 Neutral MSH2 P43246 Y874E 874 Y E 0.044 Neutral MSH2 P43246 Y874F 874 Y F 0.012 Neutral MSH2 P43246 Y874G 874 Y G 0.178 Neutral MSH2 P43246 Y874H 874 Y H 0.064 Neutral MSH2 P43246 Y874I 874 Y I 0.026 Neutral MSH2 P43246 Y874K 874 Y K 0.034 Neutral MSH2 P43246 Y874L 874 Y L 0.076 Neutral MSH2 P43246 Y874M 874 Y M 0.126 Neutral MSH2 P43246 Y874N 874 Y N 0.17 Neutral MSH2 P43246 Y874P 874 Y P 0.038 Neutral MSH2 P43246 Y874Q 874 Y Q 0.074 Neutral MSH2 P43246 Y874R 874 Y R 0.046 Neutral MSH2 P43246 Y874S 874 Y S 0.146 Neutral MSH2 P43246 Y874T 874 Y T 0.092 Neutral MSH2 P43246 Y874V 874 Y V 0.262 Neutral MSH2 P43246 Y874W 874 Y W 0.102 Neutral MSH2 P43246 L875A 875 L A 0.008 Neutral MSH2 P43246 L875C 875 L C 0.056 Neutral MSH2 P43246 L875D 875 L D 0.042 Neutral MSH2 P43246 L875E 875 L E 0.032 Neutral MSH2 P43246 L875F 875 L F 0.232 Neutral MSH2 P43246 L875G 875 L G 0.144 Neutral MSH2 P43246 L875H 875 L H 0.01 Neutral MSH2 P43246 L875I 875 L I 0.004 Neutral MSH2 P43246 L875K 875 L K 0.022 Neutral MSH2 P43246 L875M 875 L M 0.012 Neutral MSH2 P43246 L875N 875 L N 0.078 Neutral MSH2 P43246 L875P 875 L P 0.234 Neutral MSH2 P43246 L875Q 875 L Q 0.004 Neutral MSH2 P43246 L875R 875 L R 0.282 Neutral MSH2 P43246 L875S 875 L S 0.026 Neutral MSH2 P43246 L875T 875 L T 0.012 Neutral MSH2 P43246 L875V 875 L V 0 Neutral MSH2 P43246 L875W 875 L W 0.384 Neutral MSH2 P43246 L875Y 875 L Y 0.336 Neutral MSH2 P43246 E876A 876 E A 0.076 Neutral MSH2 P43246 E876C 876 E C 0.126 Neutral MSH2 P43246 E876D 876 E D 0.002 Neutral MSH2 P43246 E876F 876 E F 0.48 Neutral MSH2 P43246 E876G 876 E G 0.082 Neutral MSH2 P43246 E876H 876 E H 0.246 Neutral MSH2 P43246 E876I 876 E I 0.33 Neutral MSH2 P43246 E876K 876 E K 0.002 Neutral MSH2 P43246 E876L 876 E L 0.458 Neutral MSH2 P43246 E876M 876 E M 0.298 Neutral MSH2 P43246 E876N 876 E N 0.048 Neutral MSH2 P43246 E876P 876 E P 0.47 Neutral MSH2 P43246 E876Q 876 E Q 0.02 Neutral MSH2 P43246 E876R 876 E R 0.034 Neutral MSH2 P43246 E876S 876 E S 0.024 Neutral MSH2 P43246 E876T 876 E T 0.1 Neutral MSH2 P43246 E876V 876 E V 0.042 Neutral MSH2 P43246 E876W 876 E W 0.708 Pathogenic MSH2 P43246 E876Y 876 E Y 0.594 Pathogenic MSH2 P43246 R877A 877 R A 0.078 Neutral MSH2 P43246 R877C 877 R C 0.236 Neutral MSH2 P43246 R877D 877 R D 0.256 Neutral MSH2 P43246 R877E 877 R E 0.232 Neutral MSH2 P43246 R877F 877 R F 0.44 Neutral MSH2 P43246 R877G 877 R G 0.124 Neutral MSH2 P43246 R877H 877 R H 0.208 Neutral MSH2 P43246 R877I 877 R I 0.124 Neutral MSH2 P43246 R877K 877 R K 0.01 Neutral MSH2 P43246 R877L 877 R L 0.036 Neutral MSH2 P43246 R877M 877 R M 0.24 Neutral MSH2 P43246 R877N 877 R N 0.244 Neutral MSH2 P43246 R877P 877 R P 0.37 Neutral MSH2 P43246 R877Q 877 R Q 0.134 Neutral MSH2 P43246 R877S 877 R S 0.08 Neutral MSH2 P43246 R877T 877 R T 0.024 Neutral MSH2 P43246 R877V 877 R V 0.046 Neutral MSH2 P43246 R877W 877 R W 0.614 Pathogenic MSH2 P43246 R877Y 877 R Y 0.44 Neutral MSH2 P43246 E878A 878 E A 0.206 Neutral MSH2 P43246 E878C 878 E C 0.43 Neutral MSH2 P43246 E878D 878 E D 0.034 Neutral 4 MSH2 P43246 E878F 878 E F 0.802 Pathogenic MSH2 P43246 E878G 878 E G 0.128 Neutral MSH2 P43246 E878H 878 E H 0.56 Pathogenic MSH2 P43246 E878I 878 E I 0.868 Pathogenic MSH2 P43246 E878K 878 E K 0.046 Neutral MSH2 P43246 E878L 878 E L 0.83 Pathogenic MSH2 P43246 E878M 878 E M 0.662 Pathogenic MSH2 P43246 E878N 878 E N 0.02 Neutral MSH2 P43246 E878P 878 E P 0.86 Pathogenic MSH2 P43246 E878Q 878 E Q 0.012 Neutral MSH2 P43246 E878R 878 E R 0.122 Neutral MSH2 P43246 E878S 878 E S 0.246 Neutral MSH2 P43246 E878T 878 E T 0.6 Pathogenic MSH2 P43246 E878V 878 E V 0.488 Neutral MSH2 P43246 E878W 878 E W 0.94 Pathogenic MSH2 P43246 E878Y 878 E Y 0.888 Pathogenic MSH2 P43246 Q879A 879 Q A 0.128 Neutral MSH2 P43246 Q879C 879 Q C 0.414 Neutral MSH2 P43246 Q879D 879 Q D 0.028 Neutral MSH2 P43246 Q879E 879 Q E 0.086 Neutral MSH2 P43246 Q879F 879 Q F 0.776 Pathogenic MSH2 P43246 Q879G 879 Q G 0.442 Neutral MSH2 P43246 Q879H 879 Q H 0.74 Pathogenic MSH2 P43246 Q879I 879 Q I 0.82 Pathogenic MSH2 P43246 Q879K 879 Q K 0.39 Neutral MSH2 P43246 Q879L 879 Q L 0.198 Neutral MSH2 P43246 Q879M 879 Q M 0.678 Pathogenic MSH2 P43246 Q879N 879 Q N 0.094 Neutral MSH2 P43246 Q879P 879 Q P 0.836 Pathogenic MSH2 P43246 Q879R 879 Q R 0.048 Neutral MSH2 P43246 Q879S 879 Q S 0.112 Neutral MSH2 P43246 Q879T 879 Q T 0.314 Neutral MSH2 P43246 Q879V 879 Q V 0.1 Neutral MSH2 P43246 Q879W 879 Q W 0.908 Pathogenic MSH2 P43246 Q879Y 879 Q Y 0.85 Pathogenic MSH2 P43246 F88A 88 F A 0.148 Neutral MSH2 P43246 F88C 88 F C 0.576 Pathogenic MSH2 P43246 F88D 88 F D 0.814 Pathogenic MSH2 P43246 F88E 88 F E 0.894 Pathogenic MSH2 P43246 F88G 88 F G 0.492 Neutral MSH2 P43246 F88H 88 F H 0.64 Pathogenic MSH2 P43246 F88I 88 F I 0.116 Neutral MSH2 P43246 F88K 88 F K 0.864 Pathogenic MSH2 P43246 F88L 88 F L 0.078 Neutral MSH2 P43246 F88M 88 F M 0.656 Pathogenic MSH2 P43246 F88N 88 F N 0.732 Pathogenic MSH2 P43246 F88P 88 F P 0.924 Pathogenic MSH2 P43246 F88Q 88 F Q 0.764 Pathogenic MSH2 P43246 F88R 88 F R 0.932 Pathogenic MSH2 P43246 F88S 88 F S 0.742 Pathogenic MSH2 P43246 F88T 88 F T 0.16 Neutral MSH2 P43246 F88V 88 F V 0.166 Neutral MSH2 P43246 F88W 88 F W 0.822 Pathogenic MSH2 P43246 F88Y 88 F Y 0.566 Pathogenic MSH2 P43246 G880A 880 G A 0.246 Neutral MSH2 P43246 G880C 880 G C 0.892 Pathogenic MSH2 P43246 G880D 880 G D 0.6 Pathogenic MSH2 P43246 G880E 880 G E 0.962 Pathogenic MSH2 P43246 G880F 880 G F 0.964 Pathogenic MSH2 P43246 G880H 880 G H 0.956 Pathogenic MSH2 P43246 G880I 880 G I 0.918 Pathogenic MSH2 P43246 G880K 880 G K 0.772 Pathogenic MSH2 P43246 G880L 880 G L 0.964 Pathogenic MSH2 P43246 G880M 880 G M 0.974 Pathogenic MSH2 P43246 G880N 880 G N 0.902 Pathogenic MSH2 P43246 G880P 880 G P 0.928 Pathogenic MSH2 P43246 G880Q 880 G Q 0.948 Pathogenic MSH2 P43246 G880R 880 G R 0.986 Pathogenic MSH2 P43246 G880S 880 G S 0.322 Neutral MSH2 P43246 G880T 880 G T 0.784 Pathogenic MSH2 P43246 G880V 880 G V 0.734 Pathogenic MSH2 P43246 G880W 880 G W 0.948 Pathogenic MSH2 P43246 G880Y 880 G Y 0.936 Pathogenic MSH2 P43246 E881A 881 E A 0.112 Neutral MSH2 P43246 E881C 881 E C 0.202 Neutral MSH2 P43246 E881D 881 E D 0.01 Neutral MSH2 P43246 E881F 881 E F 0.58 Pathogenic MSH2 P43246 E881G 881 E G 0.14 Neutral MSH2 P43246 E881H 881 E H 0.024 Neutral MSH2 P43246 E881I 881 E I 0.18 Neutral MSH2 P43246 E881K 881 E K 0.204 Neutral MSH2 P43246 E881L 881 E L 0.088 Neutral MSH2 P43246 E881M 881 E M 0.468 Neutral MSH2 P43246 E881N 881 E N 0.006 Neutral MSH2 P43246 E881P 881 E P 0.634 Pathogenic MSH2 P43246 E881Q 881 E Q 0.018 Neutral MSH2 P43246 E881R 881 E R 0.024 Neutral MSH2 P43246 E881S 881 E S 0.026 Neutral MSH2 P43246 E881T 881 E T 0.022 Neutral MSH2 P43246 E881V 881 E V 0.056 Neutral MSH2 P43246 E881W 881 E W 0.814 Pathogenic MSH2 P43246 E881Y 881 E Y 0.7 Pathogenic MSH2 P43246 K882A 882 K A 0.052 Neutral MSH2 P43246 K882C 882 K C 0.142 Neutral MSH2 P43246 K882D 882 K D 0.128 Neutral MSH2 P43246 K882E 882 K E 0.01 Neutral MSH2 P43246 K882F 882 K F 0.602 Pathogenic MSH2 P43246 K882G 882 K G 0.35 Neutral MSH2 P43246 K882H 882 K H 0.198 Neutral MSH2 P43246 K882I 882 K I 0.158 Neutral MSH2 P43246 K882L 882 K L 0.318 Neutral MSH2 P43246 K882M 882 K M 0.428 Neutral MSH2 P43246 K882N 882 K N 0.042 Neutral MSH2 P43246 K882P 882 K P 0.646 Pathogenic MSH2 P43246 K882Q 882 K Q 0.018 Neutral MSH2 P43246 K882R 882 K R 0.01 Neutral MSH2 P43246 K882S 882 K S 0.042 Neutral MSH2 P43246 K882T 882 K T 0.04 Neutral MSH2 P43246 K882V 882 K V 0.076 Neutral MSH2 P43246 K882W 882 K W 0.84 Pathogenic MSH2 P43246 K882Y 882 K Y 0.756 Pathogenic MSH2 P43246 I883A 883 I A 0.214 Neutral MSH2 P43246 I883C 883 I C 0.384 Neutral MSH2 P43246 I883D 883 I D 0.57 Pathogenic MSH2 P43246 I883E 883 I E 0.144 Neutral MSH2 P43246 I883F 883 I F 0.158 Neutral MSH2 P43246 I883G 883 I G 0.558 Pathogenic MSH2 P43246 I883H 883 I H 0.18 Neutral MSH2 P43246 I883K 883 I K 0.526 Pathogenic MSH2 P43246 I883L 883 I L 0.02 Neutral MSH2 P43246 I883M 883 I M 0.056 Neutral MSH2 P43246 I883N 883 I N 0.614 Pathogenic MSH2 P43246 I883P 883 I P 0.702 Pathogenic MSH2 P43246 I883Q 883 I Q 0.588 Pathogenic MSH2 P43246 I883R 883 I R 0.568 Pathogenic MSH2 P43246 I883S 883 I S 0.424 Neutral MSH2 P43246 I883T 883 I T 0.338 Neutral MSH2 P43246 I883V 883 I V 0.216 Neutral MSH2 P43246 I883W 883 I W 0.898 Pathogenic MSH2 P43246 I883Y 883 I Y 0.904 Pathogenic MSH2 P43246 I884A 884 I A 0.074 Neutral MSH2 P43246 I884C 884 I C 0.406 Neutral MSH2 P43246 I884D 884 I D 0.608 Pathogenic MSH2 P43246 I884E 884 I E 0.59 Pathogenic MSH2 P43246 I884F 884 I F 0.332 Neutral MSH2 P43246 I884G 884 I G 0.528 Pathogenic MSH2 P43246 I884H 884 I H 0.468 Neutral MSH2 P43246 I884K 884 I K 0.606 Pathogenic MSH2 P43246 I884L 884 I L 0.012 Neutral MSH2 P43246 I884M 884 I M 0.058 Neutral MSH2 P43246 I884N 884 I N 0.634 Pathogenic MSH2 P43246 I884P 884 I P 0.752 Pathogenic MSH2 P43246 I884Q 884 I Q 0.566 Pathogenic MSH2 P43246 I884R 884 I R 0.778 Pathogenic MSH2 P43246 I884S 884 I S 0.438 Neutral MSH2 P43246 I884T 884 I T 0.338 Neutral MSH2 P43246 I884V 884 I V 0.008 Neutral MSH2 P43246 I884W 884 I W 0.902 Pathogenic MSH2 P43246 I884Y 884 I Y 0.906 Pathogenic MSH2 P43246 Q885A 885 Q A 0.118 Neutral MSH2 P43246 Q885C 885 Q C 0.394 Neutral MSH2 P43246 Q885D 885 Q D 0.026 Neutral MSH2 P43246 Q885E 885 Q E 0.02 Neutral MSH2 P43246 Q885F 885 Q F 0.756 Pathogenic MSH2 P43246 Q885G 885 Q G 0.442 Neutral MSH2 P43246 Q885H 885 Q H 0.42 Neutral MSH2 P43246 Q885I 885 Q I 0.8 Pathogenic MSH2 P43246 Q885K 885 Q K 0.04 Neutral MSH2 P43246 Q885L 885 Q L 0.192 Neutral MSH2 P43246 Q885M 885 Q M 0.666 Pathogenic MSH2 P43246 Q885N 885 Q N 0.146 Neutral MSH2 P43246 Q885P 885 Q P 0.814 Pathogenic MSH2 P43246 Q885R 885 Q R 0.048 Neutral MSH2 P43246 Q885S 885 Q S 0.08 Neutral MSH2 P43246 Q885T 885 Q T 0.562 Pathogenic MSH2 P43246 Q885V 885 Q V 0.778 Pathogenic MSH2 P43246 Q885W 885 Q W 0.886 Pathogenic MSH2 P43246 Q885Y 885 Q Y 0.9 Pathogenic MSH2 P43246 E886A 886 E A 0.206 Neutral MSH2 P43246 E886C 886 E C 0.43 Neutral MSH2 P43246 E886D 886 E D 0.018 Neutral MSH2 P43246 E886F 886 E F 0.802 Pathogenic MSH2 P43246 E886G 886 E G 0.046 Neutral MSH2 P43246 E886H 886 E H 0.658 Pathogenic MSH2 P43246 E886I 886 E I 0.87 Pathogenic MSH2 P43246 E886K 886 E K 0.062 Neutral MSH2 P43246 E886L 886 E L 0.85 Pathogenic MSH2 P43246 E886M 886 E M 0.662 Pathogenic MSH2 P43246 E886N 886 E N 0.018 Neutral MSH2 P43246 E886P 886 E P 0.86 Pathogenic MSH2 P43246 E886Q 886 E Q 0.014 Neutral MSH2 P43246 E886R 886 E R 0.184 Neutral MSH2 P43246 E886S 886 E S 0.036 Neutral MSH2 P43246 E886T 886 E T 0.048 Neutral MSH2 P43246 E886V 886 E V 0.788 Pathogenic MSH2 P43246 E886W 886 E W 0.94 Pathogenic MSH2 P43246 E886Y 886 E Y 0.89 Pathogenic MSH2 P43246 F887A 887 F A 0.234 Neutral MSH2 P43246 F887C 887 F C 0.274 Neutral MSH2 P43246 F887D 887 F D 0.52 Pathogenic MSH2 P43246 F887E 887 F E 0.586 Pathogenic MSH2 P43246 F887G 887 F G 0.338 Neutral MSH2 P43246 F887H 887 F H 0.268 Neutral MSH2 P43246 F887I 887 F I 0.118 Neutral MSH2 P43246 F887K 887 F K 0.544 Pathogenic MSH2 P43246 F887L 887 F L 0.046 Neutral MSH2 P43246 F887M 887 F M 0.07 Neutral MSH2 P43246 F887N 887 F N 0.522 Pathogenic MSH2 P43246 F887P 887 F P 0.684 Pathogenic MSH2 P43246 F887Q 887 F Q 0.546 Pathogenic MSH2 P43246 F887R 887 F R 0.548 Pathogenic MSH2 P43246 F887S 887 F S 0.296 Neutral MSH2 P43246 F887T 887 F T 0.294 Neutral MSH2 P43246 F887V 887 F V 0.104 Neutral MSH2 P43246 F887W 887 F W 0.812 Pathogenic MSH2 P43246 F887Y 887 F Y 0.366 Neutral MSH2 P43246 L888A 888 L A 0.044 Neutral MSH2 P43246 L888C 888 L C 0.294 Neutral MSH2 P43246 L888D 888 L D 0.568 Pathogenic MSH2 P43246 L888E 888 L E 0.482 Neutral MSH2 P43246 L888F 888 L F 0.344 Neutral MSH2 P43246 L888G 888 L G 0.532 Pathogenic MSH2 P43246 L888H 888 L H 0.29 Neutral MSH2 P43246 L888I 888 L I 0.064 Neutral MSH2 P43246 L888K 888 L K 0.498 Neutral MSH2 P43246 L888M 888 L M 0.068 Neutral MSH2 P43246 L888N 888 L N 0.55 Pathogenic MSH2 P43246 L888P 888 L P 0.834 Pathogenic MSH2 P43246 L888Q 888 L Q 0.276 Neutral MSH2 P43246 L888R 888 L R 0.806 Pathogenic MSH2 P43246 L888S 888 L S 0.046 Neutral MSH2 P43246 L888T 888 L T 0.088 Neutral MSH2 P43246 L888V 888 L V 0.012 Neutral MSH2 P43246 L888W 888 L W 0.824 Pathogenic MSH2 P43246 L888Y 888 L Y 0.846 Pathogenic MSH2 P43246 S889A 889 S A 0.01 Neutral MSH2 P43246 S889C 889 S C 0.002 Neutral MSH2 P43246 S889D 889 S D 0.002 Neutral MSH2 P43246 S889E 889 S E 0.142 Neutral MSH2 P43246 S889F 889 S F 0.276 Neutral MSH2 P43246 S889G 889 S G 0.036 Neutral MSH2 P43246 S889H 889 S H 0.176 Neutral MSH2 P43246 S889I 889 S I 0.026 Neutral MSH2 P43246 S889K 889 S K 0.162 Neutral MSH2 P43246 S889L 889 S L 0.068 Neutral MSH2 P43246 S889M 889 S M 0.27 Neutral MSH2 P43246 S889N 889 S N 0 Neutral MSH2 P43246 S889P 889 S P 0.116 Neutral MSH2 P43246 S889Q 889 S Q 0.186 Neutral MSH2 P43246 S889R 889 S R 0.154 Neutral MSH2 P43246 S889T 889 S T 0.02 Neutral MSH2 P43246 S889V 889 S V 0.288 Neutral MSH2 P43246 S889W 889 S W 0.49 Neutral MSH2 P43246 S889Y 889 S Y 0.404 Neutral MSH2 P43246 V89A 89 V A 0.08 Neutral MSH2 P43246 V89C 89 V C 0.706 Pathogenic MSH2 P43246 V89D 89 V D 0.87 Pathogenic MSH2 P43246 V89E 89 V E 0.982 Pathogenic MSH2 P43246 V89F 89 V F 0.87 Pathogenic MSH2 P43246 V89G 89 V G 0.482 Neutral MSH2 P43246 V89H 89 V H 0.808 Pathogenic MSH2 P43246 V89I 89 V I 0.196 Neutral MSH2 P43246 V89K 89 V K 0.974 Pathogenic MSH2 P43246 V89L 89 V L 0.216 Neutral MSH2 P43246 V89M 89 V M 0.294 Neutral MSH2 P43246 V89N 89 V N 0.934 Pathogenic MSH2 P43246 V89P 89 V P 0.974 Pathogenic MSH2 P43246 V89Q 89 V Q 0.992 Pathogenic MSH2 P43246 V89R 89 V R 0.96 Pathogenic MSH2 P43246 V89S 89 V S 0.37 Neutral MSH2 P43246 V89T 89 V T 0.298 Neutral MSH2 P43246 V89W 89 V W 0.9 Pathogenic MSH2 P43246 V89Y 89 V Y 0.926 Pathogenic MSH2 P43246 K890A 890 K A 0.102 Neutral MSH2 P43246 K890C 890 K C 0.056 Neutral MSH2 P43246 K890D 890 K D 0.002 Neutral MSH2 P43246 K890E 890 K E 0.004 Neutral MSH2 P43246 K890F 890 K F 0.358 Neutral MSH2 P43246 K890G 890 K G 0.182 Neutral MSH2 P43246 K890H 890 K H 0.036 Neutral MSH2 P43246 K890I 890 K I 0.352 Neutral MSH2 P43246 K890L 890 K L 0.046 Neutral MSH2 P43246 K890M 890 K M 0.232 Neutral MSH2 P43246 K890N 890 K N 0.068 Neutral MSH2 P43246 K890P 890 K P 0.384 Neutral MSH2 P43246 K890Q 890 K Q 0.01 Neutral MSH2 P43246 K890R 890 K R 0.006 Neutral MSH2 P43246 K890S 890 K S 0.016 Neutral MSH2 P43246 K890T 890 K T 0.016 Neutral MSH2 P43246 K890V 890 K V 0.166 Neutral MSH2 P43246 K890W 890 K W 0.672 Pathogenic MSH2 P43246 K890Y 890 K Y 0.576 Pathogenic MSH2 P43246 V891A 891 V A 0 Neutral MSH2 P43246 V891C 891 V C 0.01 Neutral MSH2 P43246 V891D 891 V D 0.196 Neutral MSH2 P43246 V891E 891 V E 0.284 Neutral MSH2 P43246 V891F 891 V F 0.322 Neutral MSH2 P43246 V891G 891 V G 0.252 Neutral MSH2 P43246 V891H 891 V H 0.228 Neutral MSH2 P43246 V891I 891 V I 0.006 Neutral MSH2 P43246 V891K 891 V K 0.296 Neutral MSH2 P43246 V891L 891 V L 0.004 Neutral MSH2 P43246 V891M 891 V M 0.17 Neutral MSH2 P43246 V891N 891 V N 0.216 Neutral MSH2 P43246 V891P 891 V P 0.048 Neutral MSH2 P43246 V891Q 891 V Q 0.352 Neutral MSH2 P43246 V891R 891 V R 0.49 Neutral MSH2 P43246 V891S 891 V S 0.076 Neutral MSH2 P43246 V891T 891 V T 0.128 Neutral MSH2 P43246 V891W 891 V W 0.306 Neutral MSH2 P43246 V891Y 891 V Y 0.474 Neutral MSH2 P43246 K892A 892 K A 0.04 Neutral MSH2 P43246 K892C 892 K C 0.098 Neutral MSH2 P43246 K892D 892 K D 0.104 Neutral MSH2 P43246 K892E 892 K E 0.138 Neutral MSH2 P43246 K892F 892 K F 0.528 Pathogenic MSH2 P43246 K892G 892 K G 0.242 Neutral MSH2 P43246 K892H 892 K H 0.102 Neutral MSH2 P43246 K892I 892 K I 0.07 Neutral MSH2 P43246 K892L 892 K L 0.058 Neutral MSH2 P43246 K892M 892 K M 0.034 Neutral MSH2 P43246 K892N 892 K N 0.138 Neutral MSH2 P43246 K892P 892 K P 0.512 Pathogenic MSH2 P43246 K892Q 892 K Q 0.176 Neutral MSH2 P43246 K892R 892 K R 0.008 Neutral MSH2 P43246 K892S 892 K S 0.048 Neutral MSH2 P43246 K892T 892 K T 0.172 Neutral MSH2 P43246 K892V 892 K V 0.052 Neutral MSH2 P43246 K892W 892 K W 0.764 Pathogenic MSH2 P43246 K892Y 892 K Y 0.654 Pathogenic MSH2 P43246 Q893A 893 Q A 0.044 Neutral MSH2 P43246 Q893C 893 Q C 0.156 Neutral MSH2 P43246 Q893D 893 Q D 0 Neutral MSH2 P43246 Q893E 893 Q E 0.008 Neutral MSH2 P43246 Q893F 893 Q F 0.414 Neutral MSH2 P43246 Q893G 893 Q G 0.076 Neutral MSH2 P43246 Q893H 893 Q H 0.402 Neutral MSH2 P43246 Q893I 893 Q I 0.438 Neutral MSH2 P43246 Q893K 893 Q K 0.028 Neutral MSH2 P43246 Q893L 893 Q L 0.132 Neutral MSH2 P43246 Q893M 893 Q M 0.32 Neutral MSH2 P43246 Q893N 893 Q N 0.024 Neutral MSH2 P43246 Q893P 893 Q P 0.452 Neutral MSH2 P43246 Q893R 893 Q R 0.01 Neutral MSH2 P43246 Q893S 893 Q S 0.042 Neutral MSH2 P43246 Q893T 893 Q T 0.212 Neutral MSH2 P43246 Q893V 893 Q V 0.42 Neutral MSH2 P43246 Q893W 893 Q W 0.674 Pathogenic MSH2 P43246 Q893Y 893 Q Y 0.6 Pathogenic MSH2 P43246 M894A 894 M A 0.128 Neutral MSH2 P43246 M894C 894 M C 0.07 Neutral MSH2 P43246 M894D 894 M D 0.22 Neutral MSH2 P43246 M894E 894 M E 0.01 Neutral MSH2 P43246 M894F 894 M F 0.18 Neutral MSH2 P43246 M894G 894 M G 0.064 Neutral MSH2 P43246 M894H 894 M H 0.094 Neutral MSH2 P43246 M894I 894 M I 0.012 Neutral MSH2 P43246 M894K 894 M K 0.024 Neutral MSH2 P43246 M894L 894 M L 0.016 Neutral MSH2 P43246 M894N 894 M N 0.26 Neutral MSH2 P43246 M894P 894 M P 0.416 Neutral MSH2 P43246 M894Q 894 M Q 0.012 Neutral MSH2 P43246 M894R 894 M R 0.056 Neutral MSH2 P43246 M894S 894 M S 0.012 Neutral MSH2 P43246 M894T 894 M T 0.008 Neutral MSH2 P43246 M894V 894 M V 0.022 Neutral MSH2 P43246 M894W 894 M W 0.668 Pathogenic MSH2 P43246 M894Y 894 M Y 0.62 Pathogenic MSH2 P43246 P895A 895 P A 0.042 Neutral MSH2 P43246 P895C 895 P C 0.234 Neutral MSH2 P43246 P895D 895 P D 0.014 Neutral MSH2 P43246 P895E 895 P E 0.082 Neutral MSH2 P43246 P895F 895 P F 0.516 Pathogenic MSH2 P43246 P895G 895 P G 0.134 Neutral MSH2 P43246 P895H 895 P H 0.444 Neutral MSH2 P43246 P895I 895 P I 0.08 Neutral MSH2 P43246 P895K 895 P K 0.074 Neutral MSH2 P43246 P895L 895 P L 0.05 Neutral MSH2 P43246 P895M 895 P M 0.13 Neutral MSH2 P43246 P895N 895 P N 0.078 Neutral MSH2 P43246 P895Q 895 P Q 0.082 Neutral MSH2 P43246 P895R 895 P R 0.304 Neutral MSH2 P43246 P895S 895 P S 0.008 Neutral MSH2 P43246 P895T 895 P T 0.254 Neutral MSH2 P43246 P895V 895 P V 0.052 Neutral MSH2 P43246 P895W 895 P W 0.61 Pathogenic MSH2 P43246 P895Y 895 P Y 0.54 Pathogenic MSH2 P43246 F896A 896 F A 0.048 Neutral MSH2 P43246 F896C 896 F C 0.114 Neutral MSH2 P43246 F896D 896 F D 0.028 Neutral MSH2 P43246 F896E 896 F E 0.134 Neutral MSH2 P43246 F896G 896 F G 0.16 Neutral MSH2 P43246 F896H 896 F H 0.064 Neutral MSH2 P43246 F896I 896 F I 0.004 Neutral MSH2 P43246 F896K 896 F K 0.05 Neutral MSH2 P43246 F896L 896 F L 0.004 Neutral MSH2 P43246 F896M 896 F M 0.078 Neutral MSH2 P43246 F896N 896 F N 0.04 Neutral MSH2 P43246 F896P 896 F P 0.142 Neutral MSH2 P43246 F896Q 896 F Q 0.19 Neutral MSH2 P43246 F896R 896 F R 0.102 Neutral MSH2 P43246 F896S 896 F S 0.018 Neutral MSH2 P43246 F896T 896 F T 0.018 Neutral MSH2 P43246 F896V 896 F V 0.012 Neutral MSH2 P43246 F896W 896 F W 0.354 Neutral MSH2 P43246 F896Y 896 F Y 0.18 Neutral MSH2 P43246 T897A 897 T A 0.002 Neutral MSH2 P43246 T897C 897 T C 0.11 Neutral MSH2 P43246 T897D 897 T D 0.03 Neutral MSH2 P43246 T897E 897 T E 0.04 Neutral MSH2 P43246 T897F 897 T F 0.312 Neutral MSH2 P43246 T897G 897 T G 0.018 Neutral MSH2 P43246 T897H 897 T H 0.174 Neutral MSH2 P43246 T897I 897 T I 0.17 Neutral MSH2 P43246 T897K 897 T K 0.022 Neutral MSH2 P43246 T897L 897 T L 0.024 Neutral MSH2 P43246 T897M 897 T M 0.268 Neutral MSH2 P43246 T897N 897 T N 0.002 Neutral MSH2 P43246 T897P 897 T P 0.028 Neutral MSH2 P43246 T897Q 897 T Q 0.006 Neutral MSH2 P43246 T897R 897 T R 0.248 Neutral MSH2 P43246 T897S 897 T S 0.002 Neutral MSH2 P43246 T897V 897 T V 0.33 Neutral MSH2 P43246 T897W 897 T W 0.706 Pathogenic MSH2 P43246 T897Y 897 T Y 0.664 Pathogenic MSH2 P43246 E898A 898 E A 0.076 Neutral MSH2 P43246 E898C 898 E C 0.108 Neutral MSH2 P43246 E898D 898 E D 0.002 Neutral MSH2 P43246 E898F 898 E F 0.474 Neutral MSH2 P43246 E898G 898 E G 0.024 Neutral MSH2 P43246 E898H 898 E H 0.158 Neutral MSH2 P43246 E898I 898 E I 0.45 Neutral MSH2 P43246 E898K 898 E K 0.002 Neutral MSH2 P43246 E898L 898 E L 0.208 Neutral MSH2 P43246 E898M 898 E M 0.12 Neutral MSH2 P43246 E898N 898 E N 0.046 Neutral MSH2 P43246 E898P 898 E P 0.462 Neutral MSH2 P43246 E898Q 898 E Q 0.004 Neutral MSH2 P43246 E898R 898 E R 0.118 Neutral MSH2 P43246 E898S 898 E S 0.016 Neutral MSH2 P43246 E898T 898 E T 0.01 Neutral MSH2 P43246 E898V 898 E V 0.374 Neutral MSH2 P43246 E898W 898 E W 0.694 Pathogenic MSH2 P43246 E898Y 898 E Y 0.58 Pathogenic MSH2 P43246 M899A 899 M A 0.05 Neutral MSH2 P43246 M899C 899 M C 0.076 Neutral MSH2 P43246 M899D 899 M D 0.244 Neutral MSH2 P43246 M899E 899 M E 0.01 Neutral MSH2 P43246 M899F 899 M F 0.404 Neutral MSH2 P43246 M899G 899 M G 0.046 Neutral MSH2 P43246 M899H 899 M H 0.05 Neutral MSH2 P43246 M899I 899 M I 0.09 Neutral MSH2 P43246 M899K 899 M K 0.024 Neutral MSH2 P43246 M899L 899 M L 0.008 Neutral MSH2 P43246 M899N 899 M N 0.164 Neutral MSH2 P43246 M899P 899 M P 0.36 Neutral MSH2 P43246 M899Q 899 M Q 0.004 Neutral MSH2 P43246 M899R 899 M R 0.056 Neutral MSH2 P43246 M899S 899 M S 0.25 Neutral MSH2 P43246 M899T 899 M T 0.284 Neutral MSH2 P43246 M899V 899 M V 0.202 Neutral MSH2 P43246 M899W 899 M W 0.682 Pathogenic MSH2 P43246 M899Y 899 M Y 0.588 Pathogenic MSH2 P43246 L9A 9 L A 0.14 Neutral MSH2 P43246 L9C 9 L C 0.102 Neutral MSH2 P43246 L9D 9 L D 0.288 Neutral MSH2 P43246 L9E 9 L E 0.056 Neutral MSH2 P43246 L9F 9 L F 0.178 Neutral MSH2 P43246 L9G 9 L G 0.27 Neutral MSH2 P43246 L9H 9 L H 0.132 Neutral MSH2 P43246 L9I 9 L I 0.084 Neutral MSH2 P43246 L9K 9 L K 0.122 Neutral MSH2 P43246 L9M 9 L M 0.04 Neutral MSH2 P43246 L9N 9 L N 0.272 Neutral MSH2 P43246 L9P 9 L P 0.354 Neutral MSH2 P43246 L9Q 9 L Q 0.11 Neutral MSH2 P43246 L9R 9 L R 0.54 Pathogenic MSH2 P43246 L9S 9 L S 0.312 Neutral MSH2 P43246 L9T 9 L T 0.138 Neutral MSH2 P43246 L9V 9 L V 0.002 Neutral MSH2 P43246 L9W 9 L W 0.386 Neutral MSH2 P43246 L9Y 9 L Y 0.572 Pathogenic MSH2 P43246 K90A 90 K A 0.7 Pathogenic MSH2 P43246 K90C 90 K C 0.58 Pathogenic MSH2 P43246 K90D 90 K D 0.768 Pathogenic MSH2 P43246 K90E 90 K E 0.874 Pathogenic MSH2 P43246 K90F 90 K F 0.964 Pathogenic MSH2 P43246 K90G 90 K G 0.31 Neutral MSH2 P43246 K90H 90 K H 0.876 Pathogenic MSH2 P43246 K90I 90 K I 0.992 Pathogenic MSH2 P43246 K90L 90 K L 0.984 Pathogenic MSH2 P43246 K90M 90 K M 0.892 Pathogenic MSH2 P43246 K90N 90 K N 0.786 Pathogenic MSH2 P43246 K90P 90 K P 0.92 Pathogenic MSH2 P43246 K90Q 90 K Q 0.39 Neutral MSH2 P43246 K90R 90 K R 0.196 Neutral MSH2 P43246 K90S 90 K S 0.292 Neutral MSH2 P43246 K90T 90 K T 0.658 Pathogenic MSH2 P43246 K90V 90 K V 0.49 Neutral MSH2 P43246 K90W 90 K W 0.984 Pathogenic MSH2 P43246 K90Y 90 K Y 0.974 Pathogenic MSH2 P43246 S900A 900 S A 0.01 Neutral MSH2 P43246 S900C 900 S C 0.07 Neutral MSH2 P43246 S900D 900 S D 0.006 Neutral MSH2 P43246 S900E 900 S E 0.28 Neutral MSH2 P43246 S900F 900 S F 0.514 Pathogenic MSH2 P43246 S900G 900 S G 0.074 Neutral MSH2 P43246 S900H 900 S H 0.442 Neutral MSH2 P43246 S900I 900 S I 0.218 Neutral MSH2 P43246 S900K 900 S K 0.372 Neutral MSH2 P43246 S900L 900 S L 0.058 Neutral MSH2 P43246 S900M 900 S M 0.564 Pathogenic MSH2 P43246 S900N 900 S N 0.012 Neutral MSH2 P43246 S900P 900 S P 0.09 Neutral MSH2 P43246 S900Q 900 S Q 0.256 Neutral MSH2 P43246 S900R 900 S R 0.438 Neutral MSH2 P43246 S900T 900 S T 0.022 Neutral MSH2 P43246 S900V 900 S V 0.044 Neutral MSH2 P43246 S900W 900 S W 0.734 Pathogenic MSH2 P43246 S900Y 900 S Y 0.69 Pathogenic MSH2 P43246 E901A 901 E A 0.082 Neutral MSH2 P43246 E901C 901 E C 0.106 Neutral MSH2 P43246 E901D 901 E D 0.004 Neutral MSH2 P43246 E901F 901 E F 0.428 Neutral MSH2 P43246 E901G 901 E G 0.03 Neutral MSH2 P43246 E901H 901 E H 0.244 Neutral MSH2 P43246 E901I 901 E I 0.33 Neutral MSH2 P43246 E901K 901 E K 0.006 Neutral MSH2 P43246 E901L 901 E L 0.062 Neutral MSH2 P43246 E901M 901 E M 0.122 Neutral MSH2 P43246 E901N 901 E N 0.05 Neutral MSH2 P43246 E901P 901 E P 0.104 Neutral MSH2 P43246 E901Q 901 E Q 0.002 Neutral MSH2 P43246 E901R 901 E R 0.07 Neutral MSH2 P43246 E901S 901 E S 0.02 Neutral MSH2 P43246 E901T 901 E T 0.016 Neutral MSH2 P43246 E901V 901 E V 0.062 Neutral MSH2 P43246 E901W 901 E W 0.7 Pathogenic MSH2 P43246 E901Y 901 E Y 0.65 Pathogenic MSH2 P43246 E902A 902 E A 0.076 Neutral MSH2 P43246 E902C 902 E C 0.124 Neutral MSH2 P43246 E902D 902 E D 0.002 Neutral MSH2 P43246 E902F 902 E F 0.43 Neutral MSH2 P43246 E902G 902 E G 0 Neutral MSH2 P43246 E902H 902 E H 0.17 Neutral MSH2 P43246 E902I 902 E I 0.328 Neutral MSH2 P43246 E902K 902 E K 0.002 Neutral MSH2 P43246 E902L 902 E L 0.112 Neutral MSH2 P43246 E902M 902 E M 0.292 Neutral MSH2 P43246 E902N 902 E N 0.002 Neutral MSH2 P43246 E902P 902 E P 0.466 Neutral MSH2 P43246 E902Q 902 E Q 0 Neutral MSH2 P43246 E902R 902 E R 0.124 Neutral MSH2 P43246 E902S 902 E S 0.016 Neutral MSH2 P43246 E902T 902 E T 0.012 Neutral MSH2 P43246 E902V 902 E V 0.044 Neutral MSH2 P43246 E902W 902 E W 0.702 Pathogenic MSH2 P43246 E902Y 902 E Y 0.588 Pathogenic MSH2 P43246 N903A 903 N A 0.014 Neutral MSH2 P43246 N903C 903 N C 0.254 Neutral MSH2 P43246 N903D 903 N D 0.012 Neutral MSH2 P43246 N903E 903 N E 0.018 Neutral MSH2 P43246 N903F 903 N F 0.58 Pathogenic MSH2 P43246 N903G 903 N G 0.026 Neutral MSH2 P43246 N903H 903 N H 0.358 Neutral MSH2 P43246 N903I 903 N I 0.424 Neutral MSH2 P43246 N903K 903 N K 0.052 Neutral MSH2 P43246 N903L 903 N L 0.428 Neutral MSH2 P43246 N903M 903 N M 0.36 Neutral MSH2 P43246 N903P 903 N P 0.386 Neutral MSH2 P43246 N903Q 903 N Q 0.12 Neutral MSH2 P43246 N903R 903 N R 0.304 Neutral MSH2 P43246 N903S 903 N S 0.01 Neutral MSH2 P43246 N903T 903 N T 0.22 Neutral MSH2 P43246 N903V 903 N V 0.438 Neutral MSH2 P43246 N903W 903 N W 0.706 Pathogenic MSH2 P43246 N903Y 903 N Y 0.664 Pathogenic MSH2 P43246 I904A 904 I A 0.012 Neutral MSH2 P43246 I904C 904 I C 0.116 Neutral MSH2 P43246 I904D 904 I D 0.108 Neutral MSH2 P43246 I904E 904 I E 0.206 Neutral MSH2 P43246 I904F 904 I F 0.334 Neutral MSH2 P43246 I904G 904 I G 0.28 Neutral MSH2 P43246 I904H 904 I H 0.142 Neutral MSH2 P43246 I904K 904 I K 0.234 Neutral MSH2 P43246 I904L 904 I L 0.002 Neutral MSH2 P43246 I904M 904 I M 0.044 Neutral MSH2 P43246 I904N 904 I N 0.25 Neutral MSH2 P43246 I904P 904 I P 0.08 Neutral MSH2 P43246 I904Q 904 I Q 0.25 Neutral MSH2 P43246 I904R 904 I R 0.452 Neutral MSH2 P43246 I904S 904 I S 0.212 Neutral MSH2 P43246 I904T 904 I T 0.104 Neutral MSH2 P43246 I904V 904 I V 0.002 Neutral MSH2 P43246 I904W 904 I W 0.518 Pathogenic MSH2 P43246 I904Y 904 I Y 0.476 Neutral MSH2 P43246 T905A 905 T A 0 Neutral MSH2 P43246 T905C 905 T C 0.034 Neutral MSH2 P43246 T905D 905 T D 0.038 Neutral MSH2 P43246 T905E 905 T E 0.024 Neutral MSH2 P43246 T905F 905 T F 0.204 Neutral MSH2 P43246 T905G 905 T G 0.002 Neutral MSH2 P43246 T905H 905 T H 0.084 Neutral MSH2 P43246 T905I 905 T I 0.042 Neutral MSH2 P43246 T905K 905 T K 0.002 Neutral MSH2 P43246 T905L 905 T L 0.016 Neutral MSH2 P43246 T905M 905 T M 0.028 Neutral MSH2 P43246 T905N 905 T N 0.002 Neutral MSH2 P43246 T905P 905 T P 0.008 Neutral MSH2 P43246 T905Q 905 T Q 0 Neutral MSH2 P43246 T905R 905 T R 0.16 Neutral MSH2 P43246 T905S 905 T S 0.032 Neutral MSH2 P43246 T905V 905 T V 0.016 Neutral MSH2 P43246 T905W 905 T W 0.442 Neutral MSH2 P43246 T905Y 905 T Y 0.308 Neutral MSH2 P43246 I906A 906 I A 0.006 Neutral MSH2 P43246 I906C 906 I C 0.082 Neutral MSH2 P43246 I906D 906 I D 0.03 Neutral MSH2 P43246 I906E 906 I E 0.032 Neutral MSH2 P43246 I906F 906 I F 0.206 Neutral MSH2 P43246 I906G 906 I G 0.108 Neutral MSH2 P43246 I906H 906 I H 0.08 Neutral MSH2 P43246 I906K 906 I K 0.042 Neutral MSH2 P43246 I906L 906 I L 0.058 Neutral MSH2 P43246 I906M 906 I M 0.02 Neutral MSH2 P43246 I906N 906 I N 0.096 Neutral MSH2 P43246 I906P 906 I P 0.174 Neutral MSH2 P43246 I906Q 906 I Q 0.108 Neutral MSH2 P43246 I906R 906 I R 0.23 Neutral MSH2 P43246 I906S 906 I S 0.072 Neutral MSH2 P43246 I906T 906 I T 0.002 Neutral MSH2 P43246 I906V 906 I V 0 Neutral MSH2 P43246 I906W 906 I W 0.344 Neutral MSH2 P43246 I906Y 906 I Y 0.298 Neutral MSH2 P43246 K907A 907 K A 0.032 Neutral MSH2 P43246 K907C 907 K C 0.05 Neutral MSH2 P43246 K907D 907 K D 0.064 Neutral MSH2 P43246 K907E 907 K E 0.004 Neutral MSH2 P43246 K907F 907 K F 0.38 Neutral MSH2 P43246 K907G 907 K G 0.176 Neutral MSH2 P43246 K907H 907 K H 0.078 Neutral MSH2 P43246 K907I 907 K I 0.386 Neutral MSH2 P43246 K907L 907 K L 0.366 Neutral MSH2 P43246 K907M 907 K M 0.168 Neutral MSH2 P43246 K907N 907 K N 0.068 Neutral MSH2 P43246 K907P 907 K P 0.36 Neutral MSH2 P43246 K907Q 907 K Q 0.124 Neutral MSH2 P43246 K907R 907 K R 0.058 Neutral MSH2 P43246 K907S 907 K S 0.28 Neutral MSH2 P43246 K907T 907 K T 0.132 Neutral MSH2 P43246 K907V 907 K V 0.296 Neutral MSH2 P43246 K907W 907 K W 0.662 Pathogenic MSH2 P43246 K907Y 907 K Y 0.566 Pathogenic MSH2 P43246 L908A 908 L A 0.074 Neutral MSH2 P43246 L908C 908 L C 0.13 Neutral MSH2 P43246 L908D 908 L D 0.072 Neutral MSH2 P43246 L908E 908 L E 0.048 Neutral MSH2 P43246 L908F 908 L F 0.294 Neutral MSH2 P43246 L908G 908 L G 0.066 Neutral MSH2 P43246 L908H 908 L H 0.122 Neutral MSH2 P43246 L908I 908 L I 0.006 Neutral MSH2 P43246 L908K 908 L K 0.028 Neutral MSH2 P43246 L908M 908 L M 0.016 Neutral MSH2 P43246 L908N 908 L N 0.044 Neutral MSH2 P43246 L908P 908 L P 0.334 Neutral MSH2 P43246 L908Q 908 L Q 0.014 Neutral MSH2 P43246 L908R 908 L R 0.356 Neutral MSH2 P43246 L908S 908 L S 0.256 Neutral MSH2 P43246 L908T 908 L T 0.17 Neutral MSH2 P43246 L908V 908 L V 0.004 Neutral MSH2 P43246 L908W 908 L W 0.526 Pathogenic MSH2 P43246 L908Y 908 L Y 0.488 Neutral MSH2 P43246 K909A 909 K A 0.028 Neutral MSH2 P43246 K909C 909 K C 0.028 Neutral MSH2 P43246 K909D 909 K D 0.002 Neutral MSH2 P43246 K909E 909 K E 0.004 Neutral MSH2 P43246 K909F 909 K F 0.228 Neutral MSH2 P43246 K909G 909 K G 0.116 Neutral MSH2 P43246 K909H 909 K H 0.01 Neutral MSH2 P43246 K909I 909 K I 0.048 Neutral MSH2 P43246 K909L 909 K L 0.042 Neutral MSH2 P43246 K909M 909 K M 0.03 Neutral MSH2 P43246 K909N 909 K N 0.082 Neutral MSH2 P43246 K909P 909 K P 0.25 Neutral MSH2 P43246 K909Q 909 K Q 0.006 Neutral MSH2 P43246 K909R 909 K R 0.002 Neutral MSH2 P43246 K909S 909 K S 0.012 Neutral MSH2 P43246 K909T 909 K T 0.092 Neutral MSH2 P43246 K909V 909 K V 0.026 Neutral MSH2 P43246 K909W 909 K W 0.444 Neutral MSH2 P43246 K909Y 909 K Y 0.366 Neutral MSH2 P43246 D91A 91 D A 0.67 Pathogenic MSH2 P43246 D91C 91 D C 0.896 Pathogenic MSH2 P43246 D91E 91 D E 0.354 Neutral MSH2 P43246 D91F 91 D F 0.982 Pathogenic MSH2 P43246 D91G 91 D G 0.224 Neutral MSH2 P43246 D91H 91 D H 0.588 Pathogenic MSH2 P43246 D91I 91 D I 0.972 Pathogenic MSH2 P43246 D91K 91 D K 0.438 Neutral MSH2 P43246 D91L 91 D L 0.474 Neutral MSH2 P43246 D91M 91 D M 0.458 Neutral MSH2 P43246 D91N 91 D N 0.086 Neutral MSH2 P43246 D91P 91 D P 0.91 Pathogenic MSH2 P43246 D91Q 91 D Q 0.232 Neutral MSH2 P43246 D91R 91 D R 0.892 Pathogenic MSH2 P43246 D91S 91 D S 0.712 Pathogenic MSH2 P43246 D91T 91 D T 0.182 Neutral MSH2 P43246 D91V 91 D V 0.99 Pathogenic MSH2 P43246 D91W 91 D W 0.986 Pathogenic MSH2 P43246 D91Y 91 D Y 0.98 Pathogenic MSH2 P43246 Q910A 910 Q A 0.036 Neutral MSH2 P43246 Q910C 910 Q C 0.088 Neutral MSH2 P43246 Q910D 910 Q D 0 Neutral MSH2 P43246 Q910E 910 Q E 0.008 Neutral MSH2 P43246 Q910F 910 Q F 0.296 Neutral MSH2 P43246 Q910G 910 Q G 0.108 Neutral MSH2 P43246 Q910H 910 Q H 0.236 Neutral MSH2 P43246 Q910I 910 Q I 0.296 Neutral MSH2 P43246 Q910K 910 Q K 0.02 Neutral MSH2 P43246 Q910L 910 Q L 0.124 Neutral MSH2 P43246 Q910M 910 Q M 0.026 Neutral MSH2 P43246 Q910N 910 Q N 0.066 Neutral MSH2 P43246 Q910P 910 Q P 0.406 Neutral MSH2 P43246 Q910R 910 Q R 0.002 Neutral MSH2 P43246 Q910S 910 Q S 0.034 Neutral MSH2 P43246 Q910T 910 Q T 0.002 Neutral MSH2 P43246 Q910V 910 Q V 0.298 Neutral MSH2 P43246 Q910W 910 Q W 0.508 Pathogenic MSH2 P43246 Q910Y 910 Q Y 0.446 Neutral MSH2 P43246 L911A 911 L A 0.03 Neutral MSH2 P43246 L911C 911 L C 0.13 Neutral MSH2 P43246 L911D 911 L D 0.054 Neutral MSH2 P43246 L911E 911 L E 0.044 Neutral MSH2 P43246 L911F 911 L F 0.204 Neutral MSH2 P43246 L911G 911 L G 0.096 Neutral MSH2 P43246 L911H 911 L H 0.122 Neutral MSH2 P43246 L911I 911 L I 0.008 Neutral MSH2 P43246 L911K 911 L K 0.028 Neutral MSH2 P43246 L911M 911 L M 0.018 Neutral MSH2 P43246 L911N 911 L N 0.234 Neutral MSH2 P43246 L911P 911 L P 0.334 Neutral MSH2 P43246 L911Q 911 L Q 0.014 Neutral MSH2 P43246 L911R 911 L R 0.496 Neutral MSH2 P43246 L911S 911 L S 0.02 Neutral MSH2 P43246 L911T 911 L T 0.022 Neutral MSH2 P43246 L911V 911 L V 0.006 Neutral MSH2 P43246 L911W 911 L W 0.526 Pathogenic MSH2 P43246 L911Y 911 L Y 0.496 Neutral MSH2 P43246 K912A 912 K A 0.126 Neutral MSH2 P43246 K912C 912 K C 0.064 Neutral MSH2 P43246 K912D 912 K D 0.016 Neutral MSH2 P43246 K912E 912 K E 0.004 Neutral MSH2 P43246 K912F 912 K F 0.056 Neutral MSH2 P43246 K912G 912 K G 0.182 Neutral MSH2 P43246 K912H 912 K H 0.084 Neutral MSH2 P43246 K912I 912 K I 0.106 Neutral MSH2 P43246 K912L 912 K L 0.048 Neutral MSH2 P43246 K912M 912 K M 0.034 Neutral MSH2 P43246 K912N 912 K N 0.13 Neutral MSH2 P43246 K912P 912 K P 0.402 Neutral MSH2 P43246 K912Q 912 K Q 0.088 Neutral MSH2 P43246 K912R 912 K R 0.006 Neutral MSH2 P43246 K912S 912 K S 0.242 Neutral MSH2 P43246 K912T 912 K T 0.282 Neutral MSH2 P43246 K912V 912 K V 0.3 Neutral MSH2 P43246 K912W 912 K W 0.706 Pathogenic MSH2 P43246 K912Y 912 K Y 0.372 Neutral MSH2 P43246 A913C 913 A C 0.134 Neutral MSH2 P43246 A913D 913 A D 0.422 Neutral MSH2 P43246 A913E 913 A E 0.372 Neutral MSH2 P43246 A913F 913 A F 0.722 Pathogenic MSH2 P43246 A913G 913 A G 0.19 Neutral MSH2 P43246 A913H 913 A H 0.504 Pathogenic MSH2 P43246 A913I 913 A I 0.666 Pathogenic MSH2 P43246 A913K 913 A K 0.358 Neutral MSH2 P43246 A913L 913 A L 0.65 Pathogenic MSH2 P43246 A913M 913 A M 0.484 Neutral MSH2 P43246 A913N 913 A N 0.392 Neutral MSH2 P43246 A913P 913 A P 0.46 Neutral MSH2 P43246 A913Q 913 A Q 0.334 Neutral MSH2 P43246 A913R 913 A R 0.394 Neutral MSH2 P43246 A913S 913 A S 0.008 Neutral MSH2 P43246 A913T 913 A T 0.104 Neutral MSH2 P43246 A913V 913 A V 0.376 Neutral MSH2 P43246 A913W 913 A W 0.754 Pathogenic MSH2 P43246 A913Y 913 A Y 0.742 Pathogenic MSH2 P43246 E914A 914 E A 0.08 Neutral MSH2 P43246 E914C 914 E C 0.108 Neutral MSH2 P43246 E914D 914 E D 0.002 Neutral MSH2 P43246 E914F 914 E F 0.422 Neutral MSH2 P43246 E914G 914 E G 0.002 Neutral MSH2 P43246 E914H 914 E H 0.05 Neutral MSH2 P43246 E914I 914 E I 0.45 Neutral MSH2 P43246 E914K 914 E K 0.002 Neutral MSH2 P43246 E914L 914 E L 0.208 Neutral MSH2 P43246 E914M 914 E M 0.278 Neutral MSH2 P43246 E914N 914 E N 0.052 Neutral MSH2 P43246 E914P 914 E P 0.462 Neutral MSH2 P43246 E914Q 914 E Q 0 Neutral MSH2 P43246 E914R 914 E R 0.098 Neutral MSH2 P43246 E914S 914 E S 0.016 Neutral MSH2 P43246 E914T 914 E T 0.012 Neutral MSH2 P43246 E914V 914 E V 0.4 Neutral MSH2 P43246 E914W 914 E W 0.694 Pathogenic MSH2 P43246 E914Y 914 E Y 0.42 Neutral MSH2 P43246 V915A 915 V A 0.004 Neutral MSH2 P43246 V915C 915 V C 0.114 Neutral MSH2 P43246 V915D 915 V D 0.038 Neutral MSH2 P43246 V915E 915 V E 0.066 Neutral MSH2 P43246 V915F 915 V F 0.378 Neutral MSH2 P43246 V915G 915 V G 0.29 Neutral MSH2 P43246 V915H 915 V H 0.234 Neutral MSH2 P43246 V915I 915 V I 0.012 Neutral MSH2 P43246 V915K 915 V K 0.086 Neutral MSH2 P43246 V915L 915 V L 0.004 Neutral MSH2 P43246 V915M 915 V M 0.03 Neutral MSH2 P43246 V915N 915 V N 0.226 Neutral MSH2 P43246 V915P 915 V P 0.354 Neutral MSH2 P43246 V915Q 915 V Q 0.076 Neutral MSH2 P43246 V915R 915 V R 0.33 Neutral MSH2 P43246 V915S 915 V S 0.082 Neutral MSH2 P43246 V915T 915 V T 0.132 Neutral MSH2 P43246 V915W 915 V W 0.556 Pathogenic MSH2 P43246 V915Y 915 V Y 0.474 Neutral MSH2 P43246 I916A 916 I A 0.026 Neutral MSH2 P43246 I916C 916 I C 0.146 Neutral MSH2 P43246 I916D 916 I D 0.226 Neutral MSH2 P43246 I916E 916 I E 0.214 Neutral MSH2 P43246 I916F 916 I F 0.126 Neutral MSH2 P43246 I916G 916 I G 0.284 Neutral MSH2 P43246 I916H 916 I H 0.152 Neutral MSH2 P43246 I916K 916 I K 0.054 Neutral MSH2 P43246 I916L 916 I L 0 Neutral MSH2 P43246 I916M 916 I M 0.034 Neutral MSH2 P43246 I916N 916 I N 0.266 Neutral MSH2 P43246 I916P 916 I P 0.266 Neutral MSH2 P43246 I916Q 916 I Q 0.108 Neutral MSH2 P43246 I916R 916 I R 0.372 Neutral MSH2 P43246 I916S 916 I S 0.158 Neutral MSH2 P43246 I916T 916 I T 0.108 Neutral MSH2 P43246 I916V 916 I V 0 Neutral MSH2 P43246 I916W 916 I W 0.548 Pathogenic MSH2 P43246 I916Y 916 I Y 0.506 Pathogenic MSH2 P43246 A917C 917 A C 0.332 Neutral MSH2 P43246 A917D 917 A D 0.424 Neutral MSH2 P43246 A917E 917 A E 0.374 Neutral MSH2 P43246 A917F 917 A F 0.728 Pathogenic MSH2 P43246 A917G 917 A G 0.228 Neutral MSH2 P43246 A917H 917 A H 0.51 Pathogenic MSH2 P43246 A917I 917 A I 0.45 Neutral MSH2 P43246 A917K 917 A K 0.346 Neutral MSH2 P43246 A917L 917 A L 0.404 Neutral MSH2 P43246 A917M 917 A M 0.462 Neutral MSH2 P43246 A917N 917 A N 0.464 Neutral MSH2 P43246 A917P 917 A P 0.466 Neutral MSH2 P43246 A917Q 917 A Q 0.322 Neutral MSH2 P43246 A917R 917 A R 0.46 Neutral MSH2 P43246 A917S 917 A S 0.006 Neutral MSH2 P43246 A917T 917 A T 0.024 Neutral MSH2 P43246 A917V 917 A V 0.426 Neutral MSH2 P43246 A917W 917 A W 0.758 Pathogenic MSH2 P43246 A917Y 917 A Y 0.762 Pathogenic MSH2 P43246 K918A 918 K A 0.032 Neutral MSH2 P43246 K918C 918 K C 0.056 Neutral MSH2 P43246 K918D 918 K D 0.1 Neutral MSH2 P43246 K918E 918 K E 0.036 Neutral MSH2 P43246 K918F 918 K F 0.386 Neutral MSH2 P43246 K918G 918 K G 0.178 Neutral MSH2 P43246 K918H 918 K H 0.016 Neutral MSH2 P43246 K918I 918 K I 0.396 Neutral MSH2 P43246 K918L 918 K L 0.082 Neutral MSH2 P43246 K918M 918 K M 0.046 Neutral MSH2 P43246 K918N 918 K N 0.122 Neutral MSH2 P43246 K918P 918 K P 0.388 Neutral MSH2 P43246 K918Q 918 K Q 0.01 Neutral MSH2 P43246 K918R 918 K R 0.006 Neutral MSH2 P43246 K918S 918 K S 0.014 Neutral MSH2 P43246 K918T 918 K T 0.034 Neutral MSH2 P43246 K918V 918 K V 0.298 Neutral MSH2 P43246 K918W 918 K W 0.678 Pathogenic MSH2 P43246 K918Y 918 K Y 0.582 Pathogenic MSH2 P43246 N919A 919 N A 0.006 Neutral MSH2 P43246 N919C 919 N C 0.25 Neutral MSH2 P43246 N919D 919 N D 0.008 Neutral MSH2 P43246 N919E 919 N E 0.052 Neutral MSH2 P43246 N919F 919 N F 0.594 Pathogenic MSH2 P43246 N919G 919 N G 0.022 Neutral MSH2 P43246 N919H 919 N H 0.374 Neutral MSH2 P43246 N919I 919 N I 0.44 Neutral MSH2 P43246 N919K 919 N K 0.036 Neutral MSH2 P43246 N919L 919 N L 0.116 Neutral MSH2 P43246 N919M 919 N M 0.376 Neutral MSH2 P43246 N919P 919 N P 0.4 Neutral MSH2 P43246 N919Q 919 N Q 0.192 Neutral MSH2 P43246 N919R 919 N R 0.25 Neutral MSH2 P43246 N919S 919 N S 0.094 Neutral MSH2 P43246 N919T 919 N T 0.228 Neutral MSH2 P43246 N919V 919 N V 0.454 Neutral MSH2 P43246 N919W 919 N W 0.724 Pathogenic MSH2 P43246 N919Y 919 N Y 0.678 Pathogenic MSH2 P43246 L92A 92 L A 0.094 Neutral MSH2 P43246 L92C 92 L C 0.096 Neutral MSH2 P43246 L92D 92 L D 0.9 Pathogenic MSH2 P43246 L92E 92 L E 0.88 Pathogenic MSH2 P43246 L92F 92 L F 0.976 Pathogenic MSH2 P43246 L92G 92 L G 0.804 Pathogenic MSH2 P43246 L92H 92 L H 0.798 Pathogenic MSH2 P43246 L92I 92 L I 0.206 Neutral MSH2 P43246 L92K 92 L K 0.748 Pathogenic MSH2 P43246 L92M 92 L M 0.754 Pathogenic MSH2 P43246 L92N 92 L N 0.77 Pathogenic MSH2 P43246 L92P 92 L P 0.998 Pathogenic MSH2 P43246 L92Q 92 L Q 0.614 Pathogenic MSH2 P43246 L92R 92 L R 0.708 Pathogenic MSH2 P43246 L92S 92 L S 0.34 Neutral MSH2 P43246 L92T 92 L T 0.59 Pathogenic MSH2 P43246 L92V 92 L V 0.094 Neutral MSH2 P43246 L92W 92 L W 0.94 Pathogenic MSH2 P43246 L92Y 92 L Y 0.902 Pathogenic MSH2 P43246 N920A 920 N A 0.01 Neutral MSH2 P43246 N920C 920 N C 0.29 Neutral MSH2 P43246 N920D 920 N D 0.012 Neutral MSH2 P43246 N920E 920 N E 0.014 Neutral MSH2 P43246 N920F 920 N F 0.59 Pathogenic MSH2 P43246 N920G 920 N G 0.248 Neutral MSH2 P43246 N920H 920 N H 0.418 Neutral MSH2 P43246 N920I 920 N I 0.45 Neutral MSH2 P43246 N920K 920 N K 0.11 Neutral MSH2 P43246 N920L 920 N L 0.11 Neutral MSH2 P43246 N920M 920 N M 0.406 Neutral MSH2 P43246 N920P 920 N P 0.406 Neutral MSH2 P43246 N920Q 920 N Q 0.188 Neutral MSH2 P43246 N920R 920 N R 0.36 Neutral MSH2 P43246 N920S 920 N S 0.034 Neutral MSH2 P43246 N920T 920 N T 0.254 Neutral MSH2 P43246 N920V 920 N V 0.448 Neutral MSH2 P43246 N920W 920 N W 0.726 Pathogenic MSH2 P43246 N920Y 920 N Y 0.68 Pathogenic MSH2 P43246 S921A 921 S A 0.01 Neutral MSH2 P43246 S921C 921 S C 0.022 Neutral MSH2 P43246 S921D 921 S D 0.024 Neutral MSH2 P43246 S921E 921 S E 0.124 Neutral MSH2 P43246 S921F 921 S F 0.264 Neutral MSH2 P43246 S921G 921 S G 0.002 Neutral MSH2 P43246 S921H 921 S H 0.17 Neutral MSH2 P43246 S921I 921 S I 0.124 Neutral MSH2 P43246 S921K 921 S K 0.146 Neutral MSH2 P43246 S921L 921 S L 0.026 Neutral MSH2 P43246 S921M 921 S M 0.28 Neutral MSH2 P43246 S921N 921 S N 0.004 Neutral MSH2 P43246 S921P 921 S P 0.056 Neutral MSH2 P43246 S921Q 921 S Q 0.132 Neutral MSH2 P43246 S921R 921 S R 0.152 Neutral MSH2 P43246 S921T 921 S T 0.02 Neutral MSH2 P43246 S921V 921 S V 0.034 Neutral MSH2 P43246 S921W 921 S W 0.49 Neutral MSH2 P43246 S921Y 921 S Y 0.386 Neutral MSH2 P43246 F922A 922 F A 0.128 Neutral MSH2 P43246 F922C 922 F C 0.13 Neutral MSH2 P43246 F922D 922 F D 0.242 Neutral MSH2 P43246 F922E 922 F E 0.28 Neutral MSH2 P43246 F922G 922 F G 0.192 Neutral MSH2 P43246 F922H 922 F H 0.108 Neutral MSH2 P43246 F922I 922 F I 0.134 Neutral MSH2 P43246 F922K 922 F K 0.146 Neutral MSH2 P43246 F922L 922 F L 0.108 Neutral MSH2 P43246 F922M 922 F M 0.088 Neutral MSH2 P43246 F922N 922 F N 0.042 Neutral MSH2 P43246 F922P 922 F P 0.278 Neutral MSH2 P43246 F922Q 922 F Q 0.244 Neutral MSH2 P43246 F922R 922 F R 0.228 Neutral MSH2 P43246 F922S 922 F S 0.098 Neutral MSH2 P43246 F922T 922 F T 0.29 Neutral MSH2 P43246 F922V 922 F V 0.012 Neutral MSH2 P43246 F922W 922 F W 0.468 Neutral MSH2 P43246 F922Y 922 F Y 0.014 Neutral MSH2 P43246 V923A 923 V A 0.002 Neutral MSH2 P43246 V923C 923 V C 0.104 Neutral MSH2 P43246 V923D 923 V D 0.084 Neutral MSH2 P43246 V923E 923 V E 0.27 Neutral MSH2 P43246 V923F 923 V F 0.226 Neutral MSH2 P43246 V923G 923 V G 0.234 Neutral MSH2 P43246 V923H 923 V H 0.22 Neutral MSH2 P43246 V923I 923 V I 0.006 Neutral MSH2 P43246 V923K 923 V K 0.09 Neutral MSH2 P43246 V923L 923 V L 0.056 Neutral MSH2 P43246 V923M 923 V M 0.168 Neutral MSH2 P43246 V923N 923 V N 0.21 Neutral MSH2 P43246 V923P 923 V P 0.048 Neutral MSH2 P43246 V923Q 923 V Q 0.136 Neutral MSH2 P43246 V923R 923 V R 0.402 Neutral MSH2 P43246 V923S 923 V S 0.076 Neutral MSH2 P43246 V923T 923 V T 0.126 Neutral MSH2 P43246 V923W 923 V W 0.518 Pathogenic MSH2 P43246 V923Y 923 V Y 0.438 Neutral MSH2 P43246 N924A 924 N A 0.092 Neutral MSH2 P43246 N924C 924 N C 0.148 Neutral MSH2 P43246 N924D 924 N D 0.008 Neutral MSH2 P43246 N924E 924 N E 0.016 Neutral MSH2 P43246 N924F 924 N F 0.318 Neutral MSH2 P43246 N924G 924 N G 0.02 Neutral MSH2 P43246 N924H 924 N H 0.132 Neutral MSH2 P43246 N924I 924 N I 0.264 Neutral MSH2 P43246 N924K 924 N K 0.038 Neutral MSH2 P43246 N924L 924 N L 0.314 Neutral MSH2 P43246 N924M 924 N M 0.22 Neutral MSH2 P43246 N924P 924 N P 0.248 Neutral MSH2 P43246 N924Q 924 N Q 0.014 Neutral MSH2 P43246 N924R 924 N R 0.15 Neutral MSH2 P43246 N924S 924 N S 0 Neutral MSH2 P43246 N924T 924 N T 0.142 Neutral MSH2 P43246 N924V 924 N V 0.262 Neutral MSH2 P43246 N924W 924 N W 0.404 Neutral MSH2 P43246 N924Y 924 N Y 0.402 Neutral MSH2 P43246 E925A 925 E A 0.066 Neutral MSH2 P43246 E925C 925 E C 0.068 Neutral MSH2 P43246 E925D 925 E D 0 Neutral MSH2 P43246 E925F 925 E F 0.312 Neutral MSH2 P43246 E925G 925 E G 0 Neutral MSH2 P43246 E925H 925 E H 0.104 Neutral MSH2 P43246 E925I 925 E I 0.158 Neutral MSH2 P43246 E925K 925 E K 0.026 Neutral MSH2 P43246 E925L 925 E L 0.038 Neutral MSH2 P43246 E925M 925 E M 0.166 Neutral MSH2 P43246 E925N 925 E N 0.002 Neutral MSH2 P43246 E925P 925 E P 0.3 Neutral MSH2 P43246 E925Q 925 E Q 0.012 Neutral MSH2 P43246 E925R 925 E R 0.03 Neutral MSH2 P43246 E925S 925 E S 0.058 Neutral MSH2 P43246 E925T 925 E T 0.02 Neutral MSH2 P43246 E925V 925 E V 0.034 Neutral MSH2 P43246 E925W 925 E W 0.43 Neutral MSH2 P43246 E925Y 925 E Y 0.338 Neutral MSH2 P43246 I926A 926 I A 0.094 Neutral MSH2 P43246 I926C 926 I C 0.082 Neutral MSH2 P43246 I926D 926 I D 0.218 Neutral MSH2 P43246 I926E 926 I E 0.058 Neutral MSH2 P43246 I926F 926 I F 0.344 Neutral MSH2 P43246 I926G 926 I G 0.278 Neutral MSH2 P43246 I926H 926 I H 0.146 Neutral MSH2 P43246 I926K 926 I K 0.144 Neutral MSH2 P43246 I926L 926 I L 0.004 Neutral MSH2 P43246 I926M 926 I M 0.224 Neutral MSH2 P43246 I926N 926 I N 0.312 Neutral MSH2 P43246 I926P 926 I P 0.252 Neutral MSH2 P43246 I926Q 926 I Q 0.112 Neutral MSH2 P43246 I926R 926 I R 0.47 Neutral MSH2 P43246 I926S 926 I S 0.216 Neutral MSH2 P43246 I926T 926 I T 0.032 Neutral MSH2 P43246 I926V 926 I V 0.004 Neutral MSH2 P43246 I926W 926 I W 0.538 Pathogenic MSH2 P43246 I926Y 926 I Y 0.496 Neutral MSH2 P43246 I927A 927 I A 0.01 Neutral MSH2 P43246 I927C 927 I C 0.122 Neutral MSH2 P43246 I927D 927 I D 0.1 Neutral MSH2 P43246 I927E 927 I E 0.174 Neutral MSH2 P43246 I927F 927 I F 0.122 Neutral MSH2 P43246 I927G 927 I G 0.246 Neutral MSH2 P43246 I927H 927 I H 0.12 Neutral MSH2 P43246 I927K 927 I K 0.19 Neutral MSH2 P43246 I927L 927 I L 0.002 Neutral MSH2 P43246 I927M 927 I M 0.136 Neutral MSH2 P43246 I927N 927 I N 0.22 Neutral MSH2 P43246 I927P 927 I P 0.216 Neutral MSH2 P43246 I927Q 927 I Q 0.104 Neutral MSH2 P43246 I927R 927 I R 0.348 Neutral MSH2 P43246 I927S 927 I S 0.148 Neutral MSH2 P43246 I927T 927 I T 0.204 Neutral MSH2 P43246 I927V 927 I V 0.004 Neutral MSH2 P43246 I927W 927 I W 0.48 Neutral MSH2 P43246 I927Y 927 I Y 0.426 Neutral MSH2 P43246 S928A 928 S A 0.01 Neutral MSH2 P43246 S928C 928 S C 0.032 Neutral MSH2 P43246 S928D 928 S D 0.008 Neutral MSH2 P43246 S928E 928 S E 0.12 Neutral MSH2 P43246 S928F 928 S F 0.268 Neutral MSH2 P43246 S928G 928 S G 0.066 Neutral MSH2 P43246 S928H 928 S H 0.242 Neutral MSH2 P43246 S928I 928 S I 0.126 Neutral MSH2 P43246 S928K 928 S K 0.152 Neutral MSH2 P43246 S928L 928 S L 0.032 Neutral MSH2 P43246 S928M 928 S M 0.304 Neutral MSH2 P43246 S928N 928 S N 0.004 Neutral MSH2 P43246 S928P 928 S P 0.098 Neutral MSH2 P43246 S928Q 928 S Q 0.17 Neutral MSH2 P43246 S928R 928 S R 0.252 Neutral MSH2 P43246 S928T 928 S T 0.104 Neutral MSH2 P43246 S928V 928 S V 0.298 Neutral MSH2 P43246 S928W 928 S W 0.502 Pathogenic MSH2 P43246 S928Y 928 S Y 0.458 Neutral MSH2 P43246 R929A 929 R A 0.064 Neutral MSH2 P43246 R929C 929 R C 0.154 Neutral MSH2 P43246 R929D 929 R D 0.182 Neutral MSH2 P43246 R929E 929 R E 0.022 Neutral MSH2 P43246 R929F 929 R F 0.294 Neutral MSH2 P43246 R929G 929 R G 0.072 Neutral MSH2 P43246 R929H 929 R H 0.016 Neutral MSH2 P43246 R929I 929 R I 0.208 Neutral MSH2 P43246 R929K 929 R K 0.022 Neutral MSH2 P43246 R929L 929 R L 0.018 Neutral MSH2 P43246 R929M 929 R M 0.164 Neutral MSH2 P43246 R929N 929 R N 0.178 Neutral MSH2 P43246 R929P 929 R P 0.282 Neutral MSH2 P43246 R929Q 929 R Q 0.116 Neutral MSH2 P43246 R929S 929 R S 0.062 Neutral MSH2 P43246 R929T 929 R T 0.144 Neutral MSH2 P43246 R929V 929 R V 0.062 Neutral MSH2 P43246 R929W 929 R W 0.444 Neutral MSH2 P43246 R929Y 929 R Y 0.308 Neutral MSH2 P43246 L93A 93 L A 0.714 Pathogenic MSH2 P43246 L93C 93 L C 0.822 Pathogenic MSH2 P43246 L93D 93 L D 0.91 Pathogenic MSH2 P43246 L93E 93 L E 0.894 Pathogenic MSH2 P43246 L93F 93 L F 0.81 Pathogenic 4 MSH2 P43246 L93G 93 L G 0.618 Pathogenic MSH2 P43246 L93H 93 L H 0.91 Pathogenic MSH2 P43246 L93I 93 L I 0.442 Neutral MSH2 P43246 L93K 93 L K 0.724 Pathogenic MSH2 P43246 L93M 93 L M 0.602 Pathogenic MSH2 P43246 L93N 93 L N 0.82 Pathogenic MSH2 P43246 L93P 93 L P 0.992 Pathogenic MSH2 P43246 L93Q 93 L Q 0.776 Pathogenic MSH2 P43246 L93R 93 L R 0.986 Pathogenic MSH2 P43246 L93S 93 L S 0.706 Pathogenic MSH2 P43246 L93T 93 L T 0.626 Pathogenic MSH2 P43246 L93V 93 L V 0.334 Neutral MSH2 P43246 L93W 93 L W 0.874 Pathogenic MSH2 P43246 L93Y 93 L Y 0.886 Pathogenic MSH2 P43246 I930A 930 I A 0.072 Neutral MSH2 P43246 I930C 930 I C 0.09 Neutral MSH2 P43246 I930D 930 I D 0.14 Neutral MSH2 P43246 I930E 930 I E 0.14 Neutral MSH2 P43246 I930F 930 I F 0.206 Neutral MSH2 P43246 I930G 930 I G 0.206 Neutral MSH2 P43246 I930H 930 I H 0.08 Neutral MSH2 P43246 I930K 930 I K 0.068 Neutral MSH2 P43246 I930L 930 I L 0.012 Neutral MSH2 P43246 I930M 930 I M 0.112 Neutral MSH2 P43246 I930N 930 I N 0.096 Neutral MSH2 P43246 I930P 930 I P 0.174 Neutral MSH2 P43246 I930Q 930 I Q 0.198 Neutral MSH2 P43246 I930R 930 I R 0.26 Neutral MSH2 P43246 I930S 930 I S 0.072 Neutral MSH2 P43246 I930T 930 I T 0.002 Neutral MSH2 P43246 I930V 930 I V 0 Neutral MSH2 P43246 I930W 930 I W 0.344 Neutral MSH2 P43246 I930Y 930 I Y 0.298 Neutral MSH2 P43246 K931A 931 K A 0.056 Neutral MSH2 P43246 K931C 931 K C 0.028 Neutral MSH2 P43246 K931D 931 K D 0.066 Neutral MSH2 P43246 K931E 931 K E 0.072 Neutral MSH2 P43246 K931F 931 K F 0.234 Neutral MSH2 P43246 K931G 931 K G 0.134 Neutral MSH2 P43246 K931H 931 K H 0.02 Neutral MSH2 P43246 K931I 931 K I 0.248 Neutral MSH2 P43246 K931L 931 K L 0.114 Neutral MSH2 P43246 K931M 931 K M 0.112 Neutral MSH2 P43246 K931N 931 K N 0.014 Neutral MSH2 P43246 K931P 931 K P 0.232 Neutral MSH2 P43246 K931Q 931 K Q 0.09 Neutral MSH2 P43246 K931R 931 K R 0.026 Neutral MSH2 P43246 K931S 931 K S 0.176 Neutral MSH2 P43246 K931T 931 K T 0.09 Neutral MSH2 P43246 K931V 931 K V 0.192 Neutral MSH2 P43246 K931W 931 K W 0.474 Neutral MSH2 P43246 K931Y 931 K Y 0.39 Neutral MSH2 P43246 V932A 932 V A 0.052 Neutral MSH2 P43246 V932C 932 V C 0.058 Neutral MSH2 P43246 V932D 932 V D 0.126 Neutral MSH2 P43246 V932E 932 V E 0.2 Neutral MSH2 P43246 V932F 932 V F 0.142 Neutral MSH2 P43246 V932G 932 V G 0.118 Neutral MSH2 P43246 V932H 932 V H 0.112 Neutral MSH2 P43246 V932I 932 V I 0.038 Neutral MSH2 P43246 V932K 932 V K 0.158 Neutral MSH2 P43246 V932L 932 V L 0.018 Neutral MSH2 P43246 V932M 932 V M 0.03 Neutral MSH2 P43246 V932N 932 V N 0.144 Neutral MSH2 P43246 V932P 932 V P 0.142 Neutral MSH2 P43246 V932Q 932 V Q 0.1 Neutral MSH2 P43246 V932R 932 V R 0.274 Neutral MSH2 P43246 V932S 932 V S 0.07 Neutral MSH2 P43246 V932T 932 V T 0.094 Neutral MSH2 P43246 V932W 932 V W 0.344 Neutral MSH2 P43246 V932Y 932 V Y 0.256 Neutral MSH2 P43246 T933A 933 T A 0.08 Neutral MSH2 P43246 T933C 933 T C 0.064 Neutral MSH2 P43246 T933D 933 T D 0.058 Neutral MSH2 P43246 T933E 933 T E 0.04 Neutral MSH2 P43246 T933F 933 T F 0.182 Neutral MSH2 P43246 T933G 933 T G 0.058 Neutral MSH2 P43246 T933H 933 T H 0.084 Neutral MSH2 P43246 T933I 933 T I 0.066 Neutral MSH2 P43246 T933K 933 T K 0.042 Neutral MSH2 P43246 T933L 933 T L 0.07 Neutral MSH2 P43246 T933M 933 T M 0.098 Neutral MSH2 P43246 T933N 933 T N 0.052 Neutral MSH2 P43246 T933P 933 T P 0.084 Neutral MSH2 P43246 T933Q 933 T Q 0.052 Neutral MSH2 P43246 T933R 933 T R 0.26 Neutral MSH2 P43246 T933S 933 T S 0 Neutral MSH2 P43246 T933V 933 T V 0.212 Neutral MSH2 P43246 T933W 933 T W 0.442 Neutral MSH2 P43246 T933Y 933 T Y 0.424 Neutral MSH2 P43246 T934A 934 T A 0.078 Neutral MSH2 P43246 T934C 934 T C 0.064 Neutral MSH2 P43246 T934D 934 T D 0.058 Neutral MSH2 P43246 T934E 934 T E 0.062 Neutral MSH2 P43246 T934F 934 T F 0.204 Neutral MSH2 P43246 T934G 934 T G 0.058 Neutral MSH2 P43246 T934H 934 T H 0.084 Neutral MSH2 P43246 T934I 934 T I 0.096 Neutral MSH2 P43246 T934K 934 T K 0.042 Neutral MSH2 P43246 T934L 934 T L 0.074 Neutral MSH2 P43246 T934M 934 T M 0.098 Neutral MSH2 P43246 T934N 934 T N 0.012 Neutral MSH2 P43246 T934P 934 T P 0.1 Neutral MSH2 P43246 T934Q 934 T Q 0.002 Neutral MSH2 P43246 T934R 934 T R 0.26 Neutral MSH2 P43246 T934S 934 T S 0 Neutral MSH2 P43246 T934V 934 T V 0.206 Neutral MSH2 P43246 T934W 934 T W 0.442 Neutral MSH2 P43246 T934Y 934 T Y 0.422 Neutral MSH2 P43246 L94A 94 L A 0.564 Pathogenic MSH2 P43246 L94C 94 L C 0.686 Pathogenic MSH2 P43246 L94D 94 L D 0.526 Pathogenic MSH2 P43246 L94E 94 L E 0.246 Neutral MSH2 P43246 L94F 94 L F 0.452 Neutral MSH2 P43246 L94G 94 L G 0.812 Pathogenic MSH2 P43246 L94H 94 L H 0.334 Neutral MSH2 P43246 L94I 94 L I 0.272 Neutral MSH2 P43246 L94K 94 L K 0.722 Pathogenic MSH2 P43246 L94M 94 L M 0.72 Pathogenic MSH2 P43246 L94N 94 L N 0.782 Pathogenic MSH2 P43246 L94P 94 L P 0.978 Pathogenic MSH2 P43246 L94Q 94 L Q 0.612 Pathogenic MSH2 P43246 L94R 94 L R 0.996 Pathogenic MSH2 P43246 L94S 94 L S 0.34 Neutral MSH2 P43246 L94T 94 L T 0.114 Neutral MSH2 P43246 L94V 94 L V 0.104 Neutral MSH2 P43246 L94W 94 L W 0.908 Pathogenic MSH2 P43246 L94Y 94 L Y 0.666 Pathogenic MSH2 P43246 V95A 95 V A 0.036 Neutral MSH2 P43246 V95C 95 V C 0.31 Neutral MSH2 P43246 V95D 95 V D 0.062 Neutral MSH2 P43246 V95E 95 V E 0.1 Neutral MSH2 P43246 V95F 95 V F 0.68 Pathogenic MSH2 P43246 V95G 95 V G 0.566 Pathogenic MSH2 P43246 V95H 95 V H 0.432 Neutral MSH2 P43246 V95I 95 V I 0.074 Neutral MSH2 P43246 V95K 95 V K 0.138 Neutral MSH2 P43246 V95L 95 V L 0.298 Neutral MSH2 P43246 V95M 95 V M 0.374 Neutral MSH2 P43246 V95N 95 V N 0.098 Neutral MSH2 P43246 V95P 95 V P 0.776 Pathogenic MSH2 P43246 V95Q 95 V Q 0.122 Neutral MSH2 P43246 V95R 95 V R 0.494 Neutral MSH2 P43246 V95S 95 V S 0.052 Neutral MSH2 P43246 V95T 95 V T 0.036 Neutral MSH2 P43246 V95W 95 V W 0.686 Pathogenic MSH2 P43246 V95Y 95 V Y 0.758 Pathogenic MSH2 P43246 R96A 96 R A 0.43 Neutral MSH2 P43246 R96C 96 R C 0.406 Neutral MSH2 P43246 R96D 96 R D 0.586 Pathogenic MSH2 P43246 R96E 96 R E 0.506 Pathogenic MSH2 P43246 R96F 96 R F 0.888 Pathogenic MSH2 P43246 R96G 96 R G 0.08 Neutral MSH2 P43246 R96H 96 R H 0.134 Neutral 2 MSH2 P43246 R96I 96 R I 0.73 Pathogenic MSH2 P43246 R96K 96 R K 0.21 Neutral MSH2 P43246 R96L 96 R L 0.226 Neutral MSH2 P43246 R96M 96 R M 0.134 Neutral MSH2 P43246 R96N 96 R N 0.356 Neutral MSH2 P43246 R96P 96 R P 0.818 Pathogenic MSH2 P43246 R96Q 96 R Q 0.062 Neutral MSH2 P43246 R96S 96 R S 0.292 Neutral MSH2 P43246 R96T 96 R T 0.532 Pathogenic MSH2 P43246 R96V 96 R V 0.614 Pathogenic MSH2 P43246 R96W 96 R W 0.868 Pathogenic MSH2 P43246 R96Y 96 R Y 0.84 Pathogenic MSH2 P43246 Q97A 97 Q A 0.374 Neutral MSH2 P43246 Q97C 97 Q C 0.492 Neutral MSH2 P43246 Q97D 97 Q D 0.022 Neutral MSH2 P43246 Q97E 97 Q E 0.274 Neutral MSH2 P43246 Q97F 97 Q F 0.838 Pathogenic MSH2 P43246 Q97G 97 Q G 0.106 Neutral MSH2 P43246 Q97H 97 Q H 0.078 Neutral MSH2 P43246 Q97I 97 Q I 0.894 Pathogenic MSH2 P43246 Q97K 97 Q K 0.174 Neutral MSH2 P43246 Q97L 97 Q L 0.752 Pathogenic MSH2 P43246 Q97M 97 Q M 0.738 Pathogenic MSH2 P43246 Q97N 97 Q N 0.07 Neutral MSH2 P43246 Q97P 97 Q P 0.854 Pathogenic MSH2 P43246 Q97R 97 Q R 0.084 Neutral MSH2 P43246 Q97S 97 Q S 0.094 Neutral MSH2 P43246 Q97T 97 Q T 0.514 Pathogenic MSH2 P43246 Q97V 97 Q V 0.844 Pathogenic MSH2 P43246 Q97W 97 Q W 0.924 Pathogenic MSH2 P43246 Q97Y 97 Q Y 0.886 Pathogenic MSH2 P43246 Y98A 98 Y A 0.232 Neutral MSH2 P43246 Y98C 98 Y C 0.28 Neutral MSH2 P43246 Y98D 98 Y D 0.572 Pathogenic MSH2 P43246 Y98E 98 Y E 0.564 Pathogenic MSH2 P43246 Y98F 98 Y F 0.034 Neutral MSH2 P43246 Y98G 98 Y G 0.258 Neutral MSH2 P43246 Y98H 98 Y H 0.024 Neutral MSH2 P43246 Y98I 98 Y I 0.474 Neutral MSH2 P43246 Y98K 98 Y K 0.062 Neutral MSH2 P43246 Y98L 98 Y L 0.048 Neutral MSH2 P43246 Y98M 98 Y M 0.036 Neutral MSH2 P43246 Y98N 98 Y N 0.17 Neutral MSH2 P43246 Y98P 98 Y P 0.412 Neutral MSH2 P43246 Y98Q 98 Y Q 0.356 Neutral MSH2 P43246 Y98R 98 Y R 0.088 Neutral MSH2 P43246 Y98S 98 Y S 0.256 Neutral MSH2 P43246 Y98T 98 Y T 0.324 Neutral MSH2 P43246 Y98V 98 Y V 0.406 Neutral MSH2 P43246 Y98W 98 Y W 0.524 Pathogenic MSH2 P43246 R99A 99 R A 0.564 Pathogenic MSH2 P43246 R99C 99 R C 0.434 Neutral MSH2 P43246 R99D 99 R D 0.872 Pathogenic MSH2 P43246 R99E 99 R E 0.864 Pathogenic MSH2 P43246 R99F 99 R F 0.974 Pathogenic MSH2 P43246 R99G 99 R G 0.43 Neutral MSH2 P43246 R99H 99 R H 0.568 Pathogenic MSH2 P43246 R99I 99 R I 0.72 Pathogenic MSH2 P43246 R99K 99 R K 0.332 Neutral MSH2 P43246 R99L 99 R L 0.99 Pathogenic MSH2 P43246 R99M 99 R M 0.806 Pathogenic MSH2 P43246 R99N 99 R N 0.348 Neutral MSH2 P43246 R99P 99 R P 0.99 Pathogenic MSH2 P43246 R99Q 99 R Q 0.632 Pathogenic MSH2 P43246 R99S 99 R S 0.374 Neutral MSH2 P43246 R99T 99 R T 0.16 Neutral MSH2 P43246 R99V 99 R V 0.664 Pathogenic MSH2 P43246 R99W 99 R W 0.97 Pathogenic MSH2 P43246 R99Y 99 R Y 0.976 Pathogenic MSH6 P52701 M1A 1 M A 0.076 Neutral MSH6 P52701 M1C 1 M C 0.042 Neutral MSH6 P52701 M1D 1 M D 0.162 Neutral MSH6 P52701 M1E 1 M E 0.062 Neutral MSH6 P52701 M1F 1 M F 0.22 Neutral MSH6 P52701 M1G 1 M G 0.12 Neutral MSH6 P52701 M1H 1 M H 0.058 Neutral MSH6 P52701 M1I 1 M I 0.09 Neutral MSH6 P52701 M1K 1 M K 0.082 Neutral MSH6 P52701 M1L 1 M L 0.09 Neutral MSH6 P52701 M1N 1 M N 0.194 Neutral MSH6 P52701 M1P 1 M P 0.272 Neutral MSH6 P52701 M1Q 1 M Q 0.068 Neutral MSH6 P52701 M1R 1 M R 0.178 Neutral MSH6 P52701 M1S 1 M S 0.162 Neutral MSH6 P52701 M1T 1 M T 0.146 Neutral MSH6 P52701 M1V 1 M V 0.126 Neutral MSH6 P52701 M1W 1 M W 0.454 Neutral MSH6 P52701 M1Y 1 M Y 0.37 Neutral MSH6 P52701 F10A 10 F A 0.1 Neutral MSH6 P52701 F10C 10 F C 0.088 Neutral MSH6 P52701 F10D 10 F D 0.162 Neutral MSH6 P52701 F10E 10 F E 0.192 Neutral MSH6 P52701 F10G 10 F G 0.136 Neutral MSH6 P52701 F10H 10 F H 0.052 Neutral MSH6 P52701 F10I 10 F I 0.076 Neutral MSH6 P52701 F10K 10 F K 0.184 Neutral MSH6 P52701 F10L 10 F L 0.06 Neutral MSH6 P52701 F10M 10 F M 0.086 Neutral MSH6 P52701 F10N 10 F N 0.174 Neutral MSH6 P52701 F10P 10 F P 0.178 Neutral MSH6 P52701 F10Q 10 F Q 0.172 Neutral MSH6 P52701 F10R 10 F R 0.142 Neutral MSH6 P52701 F10S 10 F S 0.086 Neutral MSH6 P52701 F10T 10 F T 0.026 Neutral MSH6 P52701 F10V 10 F V 0.166 Neutral MSH6 P52701 F10W 10 F W 0.268 Neutral MSH6 P52701 F10Y 10 F Y 0.156 Neutral MSH6 P52701 M100A 100 M A 0.11 Neutral MSH6 P52701 M100C 100 M C 0.07 Neutral MSH6 P52701 M100D 100 M D 0.222 Neutral MSH6 P52701 M100E 100 M E 0.104 Neutral MSH6 P52701 M100F 100 M F 0.332 Neutral MSH6 P52701 M100G 100 M G 0.158 Neutral MSH6 P52701 M100H 100 M H 0.096 Neutral MSH6 P52701 M100I 100 M I 0.174 Neutral MSH6 P52701 M100K 100 M K 0.15 Neutral MSH6 P52701 M100L 100 M L 0.008 Neutral MSH6 P52701 M100N 100 M N 0.26 Neutral MSH6 P52701 M100P 100 M P 0.392 Neutral MSH6 P52701 M100Q 100 M Q 0.1 Neutral MSH6 P52701 M100R 100 M R 0.258 Neutral MSH6 P52701 M100S 100 M S 0.22 Neutral MSH6 P52701 M100T 100 M T 0.2 Neutral MSH6 P52701 M100V 100 M V 0.034 Neutral MSH6 P52701 M100W 100 M W 0.646 Pathogenic MSH6 P52701 M100Y 100 M Y 0.55 Pathogenic MSH6 P52701 K1000A 1000 K A 0.498 Neutral MSH6 P52701 K1000C 1000 K C 0.41 Neutral MSH6 P52701 K1000D 1000 K D 0.582 Pathogenic MSH6 P52701 K1000E 1000 K E 0.672 Pathogenic MSH6 P52701 K1000F 1000 K F 0.896 Pathogenic MSH6 P52701 K1000G 1000 K G 0.544 Pathogenic MSH6 P52701 K1000H 1000 K H 0.69 Pathogenic MSH6 P52701 K1000I 1000 K I 0.966 Pathogenic MSH6 P52701 K1000L 1000 K L 0.674 Pathogenic MSH6 P52701 K1000M 1000 K M 0.784 Pathogenic MSH6 P52701 K1000N 1000 K N 0.646 Pathogenic MSH6 P52701 K1000P 1000 K P 0.862 Pathogenic MSH6 P52701 K1000Q 1000 K Q 0.706 Pathogenic MSH6 P52701 K1000R 1000 K R 0.096 Neutral MSH6 P52701 K1000S 1000 K S 0.186 Neutral MSH6 P52701 K1000T 1000 K T 0.148 Neutral MSH6 P52701 K1000V 1000 K V 0.264 Neutral MSH6 P52701 K1000W 1000 K W 0.972 Pathogenic MSH6 P52701 K1000Y 1000 K Y 0.954 Pathogenic MSH6 P52701 K1001A 1001 K A 0.174 Neutral MSH6 P52701 K1001C 1001 K C 0.576 Pathogenic MSH6 P52701 K1001D 1001 K D 0.76 Pathogenic MSH6 P52701 K1001E 1001 K E 0.87 Pathogenic MSH6 P52701 K1001F 1001 K F 0.97 Pathogenic MSH6 P52701 K1001G 1001 K G 0.54 Pathogenic MSH6 P52701 K1001H 1001 K H 0.87 Pathogenic MSH6 P52701 K1001I 1001 K I 0.99 Pathogenic MSH6 P52701 K1001L 1001 K L 0.982 Pathogenic MSH6 P52701 K1001M 1001 K M 0.918 Pathogenic MSH6 P52701 K1001N 1001 K N 0.248 Neutral MSH6 P52701 K1001P 1001 K P 0.922 Pathogenic MSH6 P52701 K1001Q 1001 K Q 0.386 Neutral MSH6 P52701 K1001R 1001 K R 0.244 Neutral MSH6 P52701 K1001S 1001 K S 0.126 Neutral MSH6 P52701 K1001T 1001 K T 0.266 Neutral MSH6 P52701 K1001V 1001 K V 0.886 Pathogenic MSH6 P52701 K1001W 1001 K W 0.99 Pathogenic MSH6 P52701 K1001Y 1001 K Y 0.982 Pathogenic MSH6 P52701 G1002A 1002 G A 0.29 Neutral MSH6 P52701 G1002C 1002 G C 0.918 Pathogenic MSH6 P52701 G1002D 1002 G D 0.538 Pathogenic MSH6 P52701 G1002E 1002 G E 0.98 Pathogenic MSH6 P52701 G1002F 1002 G F 0.988 Pathogenic MSH6 P52701 G1002H 1002 G H 0.988 Pathogenic MSH6 P52701 G1002I 1002 G I 0.978 Pathogenic MSH6 P52701 G1002K 1002 G K 0.672 Pathogenic MSH6 P52701 G1002L 1002 G L 0.988 Pathogenic MSH6 P52701 G1002M 1002 G M 0.992 Pathogenic MSH6 P52701 G1002N 1002 G N 0.92 Pathogenic MSH6 P52701 G1002P 1002 G P 0.978 Pathogenic MSH6 P52701 G1002Q 1002 G Q 0.56 Pathogenic MSH6 P52701 G1002R 1002 G R 0.998 Pathogenic MSH6 P52701 G1002S 1002 G S 0.318 Neutral MSH6 P52701 G1002T 1002 G T 0.664 Pathogenic MSH6 P52701 G1002V 1002 G V 0.99 Pathogenic MSH6 P52701 G1002W 1002 G W 0.978 Pathogenic MSH6 P52701 G1002Y 1002 G Y 0.982 Pathogenic MSH6 P52701 C1003A 1003 C A 0.068 Neutral MSH6 P52701 C1003D 1003 C D 0.52 Pathogenic MSH6 P52701 C1003E 1003 C E 0.582 Pathogenic MSH6 P52701 C1003F 1003 C F 0.588 Pathogenic MSH6 P52701 C1003G 1003 C G 0.47 Neutral MSH6 P52701 C1003H 1003 C H 0.516 Pathogenic MSH6 P52701 C1003I 1003 C I 0.838 Pathogenic MSH6 P52701 C1003K 1003 C K 0.094 Neutral MSH6 P52701 C1003L 1003 C L 0.804 Pathogenic MSH6 P52701 C1003M 1003 C M 0.622 Pathogenic MSH6 P52701 C1003N 1003 C N 0.166 Neutral MSH6 P52701 C1003P 1003 C P 0.858 Pathogenic MSH6 P52701 C1003Q 1003 C Q 0.502 Pathogenic MSH6 P52701 C1003R 1003 C R 0.914 Pathogenic MSH6 P52701 C1003S 1003 C S 0.444 Neutral MSH6 P52701 C1003T 1003 C T 0.476 Neutral MSH6 P52701 C1003V 1003 C V 0.058 Neutral MSH6 P52701 C1003W 1003 C W 0.602 Pathogenic MSH6 P52701 C1003Y 1003 C Y 0.572 Pathogenic MSH6 P52701 K1004A 1004 K A 0.394 Neutral MSH6 P52701 K1004C 1004 K C 0.074 Neutral MSH6 P52701 K1004D 1004 K D 0.176 Neutral MSH6 P52701 K1004E 1004 K E 0.554 Pathogenic MSH6 P52701 K1004F 1004 K F 0.316 Neutral MSH6 P52701 K1004G 1004 K G 0.166 Neutral MSH6 P52701 K1004H 1004 K H 0.574 Pathogenic MSH6 P52701 K1004I 1004 K I 0.308 Neutral MSH6 P52701 K1004L 1004 K L 0.446 Neutral MSH6 P52701 K1004M 1004 K M 0.688 Pathogenic MSH6 P52701 K1004N 1004 K N 0.088 Neutral MSH6 P52701 K1004P 1004 K P 0.82 Pathogenic MSH6 P52701 K1004Q 1004 K Q 0.138 Neutral MSH6 P52701 K1004R 1004 K R 0.114 Neutral MSH6 P52701 K1004S 1004 K S 0.132 Neutral MSH6 P52701 K1004T 1004 K T 0.114 Neutral MSH6 P52701 K1004V 1004 K V 0.532 Pathogenic MSH6 P52701 K1004W 1004 K W 0.944 Pathogenic MSH6 P52701 K1004Y 1004 K Y 0.488 Neutral MSH6 P52701 R1005A 1005 R A 0.284 Neutral MSH6 P52701 R1005C 1005 R C 0.964 Pathogenic MSH6 P52701 R1005D 1005 R D 0.772 Pathogenic MSH6 P52701 R1005E 1005 R E 0.804 Pathogenic MSH6 P52701 R1005F 1005 R F 0.752 Pathogenic MSH6 P52701 R1005G 1005 R G 0.084 Neutral MSH6 P52701 R1005H 1005 R H 0.442 Neutral MSH6 P52701 R1005I 1005 R I 0.978 Pathogenic MSH6 P52701 R1005K 1005 R K 0.33 Neutral MSH6 P52701 R1005L 1005 R L 0.988 Pathogenic MSH6 P52701 R1005M 1005 R M 0.78 Pathogenic MSH6 P52701 R1005N 1005 R N 0.7 Pathogenic MSH6 P52701 R1005P 1005 R P 0.358 Neutral MSH6 P52701 R1005Q 1005 R Q 0.252 Neutral MSH6 P52701 R1005S 1005 R S 0.162 Neutral MSH6 P52701 R1005T 1005 R T 0.944 Pathogenic MSH6 P52701 R1005V 1005 R V 0.98 Pathogenic MSH6 P52701 R1005W 1005 R W 0.958 Pathogenic MSH6 P52701 R1005Y 1005 R Y 0.966 Pathogenic MSH6 P52701 Y1006A 1006 Y A 0.144 Neutral MSH6 P52701 Y1006C 1006 Y C 0.28 Neutral MSH6 P52701 Y1006D 1006 Y D 0.79 Pathogenic MSH6 P52701 Y1006E 1006 Y E 0.708 Pathogenic MSH6 P52701 Y1006F 1006 Y F 0.062 Neutral MSH6 P52701 Y1006G 1006 Y G 0.378 Neutral MSH6 P52701 Y1006H 1006 Y H 0.462 Neutral MSH6 P52701 Y1006I 1006 Y I 0.258 Neutral MSH6 P52701 Y1006K 1006 Y K 0.418 Neutral MSH6 P52701 Y1006L 1006 Y L 0.192 Neutral MSH6 P52701 Y1006M 1006 Y M 0.116 Neutral MSH6 P52701 Y1006N 1006 Y N 0.614 Pathogenic MSH6 P52701 Y1006P 1006 Y P 0.702 Pathogenic MSH6 P52701 Y1006Q 1006 Y Q 0.526 Pathogenic MSH6 P52701 Y1006R 1006 Y R 0.74 Pathogenic MSH6 P52701 Y1006S 1006 Y S 0.162 Neutral MSH6 P52701 Y1006T 1006 Y T 0.266 Neutral MSH6 P52701 Y1006V 1006 Y V 0.158 Neutral MSH6 P52701 Y1006W 1006 Y W 0.214 Neutral MSH6 P52701 W1007A 1007 W A 0.228 Neutral MSH6 P52701 W1007C 1007 W C 0.228 Neutral MSH6 P52701 W1007D 1007 W D 0.352 Neutral MSH6 P52701 W1007E 1007 W E 0.504 Pathogenic MSH6 P52701 W1007F 1007 W F 0.282 Neutral MSH6 P52701 W1007G 1007 W G 0.258 Neutral MSH6 P52701 W1007H 1007 W H 0.07 Neutral MSH6 P52701 W1007I 1007 W I 0.352 Neutral MSH6 P52701 W1007K 1007 W K 0.126 Neutral MSH6 P52701 W1007L 1007 W L 0.23 Neutral MSH6 P52701 W1007M 1007 W M 0.256 Neutral MSH6 P52701 W1007N 1007 W N 0.306 Neutral MSH6 P52701 W1007P 1007 W P 0.35 Neutral MSH6 P52701 W1007Q 1007 W Q 0.33 Neutral MSH6 P52701 W1007R 1007 W R 0.076 Neutral MSH6 P52701 W1007S 1007 W S 0.18 Neutral MSH6 P52701 W1007T 1007 W T 0.136 Neutral MSH6 P52701 W1007V 1007 W V 0.036 Neutral MSH6 P52701 W1007Y 1007 W Y 0.03 Neutral MSH6 P52701 T1008A 1008 T A 0.238 Neutral MSH6 P52701 T1008C 1008 T C 0.374 Neutral MSH6 P52701 T1008D 1008 T D 0.42 Neutral MSH6 P52701 T1008E 1008 T E 0.844 Pathogenic MSH6 P52701 T1008F 1008 T F 0.55 Pathogenic MSH6 P52701 T1008G 1008 T G 0.532 Pathogenic MSH6 P52701 T1008H 1008 T H 0.788 Pathogenic MSH6 P52701 T1008I 1008 T I 0.808 Pathogenic MSH6 P52701 T1008K 1008 T K 0.798 Pathogenic MSH6 P52701 T1008L 1008 T L 0.798 Pathogenic MSH6 P52701 T1008M 1008 T M 0.896 Pathogenic MSH6 P52701 T1008N 1008 T N 0.098 Neutral MSH6 P52701 T1008P 1008 T P 0.324 Neutral MSH6 P52701 T1008Q 1008 T Q 0.696 Pathogenic MSH6 P52701 T1008R 1008 T R 0.522 Pathogenic MSH6 P52701 T1008S 1008 T S 0.072 Neutral MSH6 P52701 T1008V 1008 T V 0.77 Pathogenic MSH6 P52701 T1008W 1008 T W 0.944 Pathogenic MSH6 P52701 T1008Y 1008 T Y 0.944 Pathogenic MSH6 P52701 K1009A 1009 K A 0.078 Neutral MSH6 P52701 K1009C 1009 K C 0.188 Neutral MSH6 P52701 K1009D 1009 K D 0.03 Neutral MSH6 P52701 K1009E 1009 K E 0.032 Neutral MSH6 P52701 K1009F 1009 K F 0.66 Pathogenic MSH6 P52701 K1009G 1009 K G 0.098 Neutral MSH6 P52701 K1009H 1009 K H 0.21 Neutral MSH6 P52701 K1009I 1009 K I 0.122 Neutral MSH6 P52701 K1009L 1009 K L 0.666 Pathogenic MSH6 P52701 K1009M 1009 K M 0.498 Neutral MSH6 P52701 K1009N 1009 K N 0.04 Neutral MSH6 P52701 K1009P 1009 K P 0.078 Neutral MSH6 P52701 K1009Q 1009 K Q 0.042 Neutral MSH6 P52701 K1009R 1009 K R 0.034 Neutral MSH6 P52701 K1009S 1009 K S 0.064 Neutral MSH6 P52701 K1009T 1009 K T 0.07 Neutral MSH6 P52701 K1009V 1009 K V 0.204 Neutral MSH6 P52701 K1009W 1009 K W 0.884 Pathogenic MSH6 P52701 K1009Y 1009 K Y 0.808 Pathogenic MSH6 P52701 E101A 101 E A 0.178 Neutral MSH6 P52701 E101C 101 E C 0.118 Neutral MSH6 P52701 E101D 101 E D 0.07 Neutral MSH6 P52701 E101F 101 E F 0.422 Neutral MSH6 P52701 E101G 101 E G 0.078 Neutral MSH6 P52701 E101H 101 E H 0.17 Neutral MSH6 P52701 E101I 101 E I 0.444 Neutral MSH6 P52701 E101K 101 E K 0.276 Neutral MSH6 P52701 E101L 101 E L 0.444 Neutral MSH6 P52701 E101M 101 E M 0.282 Neutral MSH6 P52701 E101N 101 E N 0.086 Neutral MSH6 P52701 E101P 101 E P 0.184 Neutral MSH6 P52701 E101Q 101 E Q 0.024 Neutral MSH6 P52701 E101R 101 E R 0.118 Neutral MSH6 P52701 E101S 101 E S 0.224 Neutral MSH6 P52701 E101T 101 E T 0.216 Neutral MSH6 P52701 E101V 101 E V 0.392 Neutral MSH6 P52701 E101W 101 E W 0.696 Pathogenic MSH6 P52701 E101Y 101 E Y 0.58 Pathogenic MSH6 P52701 T1010A 1010 T A 0.29 Neutral MSH6 P52701 T1010C 1010 T C 0.354 Neutral MSH6 P52701 T1010D 1010 T D 0.122 Neutral MSH6 P52701 T1010E 1010 T E 0.156 Neutral MSH6 P52701 T1010F 1010 T F 0.476 Neutral MSH6 P52701 T1010G 1010 T G 0.278 Neutral MSH6 P52701 T1010H 1010 T H 0.466 Neutral MSH6 P52701 T1010I 1010 T I 0.45 Neutral MSH6 P52701 T1010K 1010 T K 0.102 Neutral MSH6 P52701 T1010L 1010 T L 0.11 Neutral MSH6 P52701 T1010M 1010 T M 0.7 Pathogenic MSH6 P52701 T1010N 1010 T N 0.076 Neutral MSH6 P52701 T1010P 1010 T P 0.64 Pathogenic MSH6 P52701 T1010Q 1010 T Q 0.176 Neutral MSH6 P52701 T1010R 1010 T R 0.496 Neutral MSH6 P52701 T1010S 1010 T S 0.106 Neutral MSH6 P52701 T1010V 1010 T V 0.382 Neutral MSH6 P52701 T1010W 1010 T W 0.92 Pathogenic MSH6 P52701 T1010Y 1010 T Y 0.752 Pathogenic MSH6 P52701 I1011A 1011 I A 0.05 Neutral MSH6 P52701 I1011C 1011 I C 0.416 Neutral MSH6 P52701 I1011D 1011 I D 0.616 Pathogenic MSH6 P52701 I1011E 1011 I E 0.598 Pathogenic MSH6 P52701 I1011F 1011 I F 0.136 Neutral MSH6 P52701 I1011G 1011 I G 0.5 Pathogenic MSH6 P52701 I1011H 1011 I H 0.486 Neutral MSH6 P52701 I1011K 1011 I K 0.612 Pathogenic MSH6 P52701 I1011L 1011 I L 0.002 Neutral MSH6 P52701 I1011M 1011 I M 0.4 Neutral MSH6 P52701 I1011N 1011 I N 0.66 Pathogenic MSH6 P52701 I1011P 1011 I P 0.764 Pathogenic MSH6 P52701 I1011Q 1011 I Q 0.634 Pathogenic MSH6 P52701 I1011R 1011 I R 0.83 Pathogenic MSH6 P52701 I1011S 1011 I S 0.1 Neutral MSH6 P52701 I1011T 1011 I T 0.02 Neutral MSH6 P52701 I1011V 1011 I V 0 Neutral MSH6 P52701 I1011W 1011 I W 0.894 Pathogenic MSH6 P52701 I1011Y 1011 I Y 0.892 Pathogenic MSH6 P52701 E1012A 1012 E A 0.23 Neutral MSH6 P52701 E1012C 1012 E C 0.454 Neutral MSH6 P52701 E1012D 1012 E D 0.106 Neutral MSH6 P52701 E1012F 1012 E F 0.834 Pathogenic MSH6 P52701 E1012G 1012 E G 0.036 Neutral MSH6 P52701 E1012H 1012 E H 0.592 Pathogenic MSH6 P52701 E1012I 1012 E I 0.902 Pathogenic MSH6 P52701 E1012K 1012 E K 0.046 Neutral MSH6 P52701 E1012L 1012 E L 0.814 Pathogenic MSH6 P52701 E1012M 1012 E M 0.68 Pathogenic MSH6 P52701 E1012N 1012 E N 0.05 Neutral MSH6 P52701 E1012P 1012 E P 0.77 Pathogenic MSH6 P52701 E1012Q 1012 E Q 0.026 Neutral MSH6 P52701 E1012R 1012 E R 0.126 Neutral MSH6 P52701 E1012S 1012 E S 0.054 Neutral MSH6 P52701 E1012T 1012 E T 0.066 Neutral MSH6 P52701 E1012V 1012 E V 0.818 Pathogenic MSH6 P52701 E1012W 1012 E W 0.968 Pathogenic MSH6 P52701 E1012Y 1012 E Y 0.906 Pathogenic MSH6 P52701 K1013A 1013 K A 0.096 Neutral MSH6 P52701 K1013C 1013 K C 0.136 Neutral MSH6 P52701 K1013D 1013 K D 0.03 Neutral MSH6 P52701 K1013E 1013 K E 0.028 Neutral MSH6 P52701 K1013F 1013 K F 0.788 Pathogenic MSH6 P52701 K1013G 1013 K G 0.128 Neutral MSH6 P52701 K1013H 1013 K H 0.28 Neutral MSH6 P52701 K1013I 1013 K I 0.83 Pathogenic MSH6 P52701 K1013L 1013 K L 0.7 Pathogenic MSH6 P52701 K1013M 1013 K M 0.568 Pathogenic MSH6 P52701 K1013N 1013 K N 0.046 Neutral MSH6 P52701 K1013P 1013 K P 0.758 Pathogenic MSH6 P52701 K1013Q 1013 K Q 0.042 Neutral MSH6 P52701 K1013R 1013 K R 0.036 Neutral MSH6 P52701 K1013S 1013 K S 0.052 Neutral MSH6 P52701 K1013T 1013 K T 0.058 Neutral MSH6 P52701 K1013V 1013 K V 0.7 Pathogenic MSH6 P52701 K1013W 1013 K W 0.96 Pathogenic MSH6 P52701 K1013Y 1013 K Y 0.902 Pathogenic MSH6 P52701 K1014A 1014 K A 0.54 Pathogenic MSH6 P52701 K1014C 1014 K C 0.432 Neutral MSH6 P52701 K1014D 1014 K D 0.604 Pathogenic MSH6 P52701 K1014E 1014 K E 0.264 Neutral MSH6 P52701 K1014F 1014 K F 0.398 Neutral MSH6 P52701 K1014G 1014 K G 0.534 Pathogenic MSH6 P52701 K1014H 1014 K H 0.736 Pathogenic MSH6 P52701 K1014I 1014 K I 0.988 Pathogenic MSH6 P52701 K1014L 1014 K L 0.318 Neutral MSH6 P52701 K1014M 1014 K M 0.148 Neutral MSH6 P52701 K1014N 1014 K N 0.648 Pathogenic MSH6 P52701 K1014P 1014 K P 0.922 Pathogenic MSH6 P52701 K1014Q 1014 K Q 0.278 Neutral MSH6 P52701 K1014R 1014 K R 0.732 Pathogenic MSH6 P52701 K1014S 1014 K S 0.708 Pathogenic MSH6 P52701 K1014T 1014 K T 0.62 Pathogenic MSH6 P52701 K1014V 1014 K V 0.236 Neutral MSH6 P52701 K1014W 1014 K W 0.898 Pathogenic MSH6 P52701 K1014Y 1014 K Y 0.886 Pathogenic MSH6 P52701 L1015A 1015 L A 0.072 Neutral MSH6 P52701 L1015C 1015 L C 0.202 Neutral MSH6 P52701 L1015D 1015 L D 0.114 Neutral MSH6 P52701 L1015E 1015 L E 0.094 Neutral MSH6 P52701 L1015F 1015 L F 0.296 Neutral MSH6 P52701 L1015G 1015 L G 0.396 Neutral MSH6 P52701 L1015H 1015 L H 0.174 Neutral MSH6 P52701 L1015I 1015 L I 0.104 Neutral MSH6 P52701 L1015K 1015 L K 0.074 Neutral MSH6 P52701 L1015M 1015 L M 0.094 Neutral MSH6 P52701 L1015N 1015 L N 0.546 Pathogenic MSH6 P52701 L1015P 1015 L P 0.856 Pathogenic MSH6 P52701 L1015Q 1015 L Q 0.058 Neutral MSH6 P52701 L1015R 1015 L R 0.816 Pathogenic MSH6 P52701 L1015S 1015 L S 0.068 Neutral MSH6 P52701 L1015T 1015 L T 0.288 Neutral MSH6 P52701 L1015V 1015 L V 0.03 Neutral MSH6 P52701 L1015W 1015 L W 0.838 Pathogenic MSH6 P52701 L1015Y 1015 L Y 0.832 Pathogenic MSH6 P52701 A1016C 1016 A C 0.22 Neutral MSH6 P52701 A1016D 1016 A D 0.386 Neutral MSH6 P52701 A1016E 1016 A E 0.304 Neutral MSH6 P52701 A1016F 1016 A F 0.54 Pathogenic MSH6 P52701 A1016G 1016 A G 0.024 Neutral MSH6 P52701 A1016H 1016 A H 0.324 Neutral MSH6 P52701 A1016I 1016 A I 0.474 Neutral MSH6 P52701 A1016K 1016 A K 0.298 Neutral MSH6 P52701 A1016L 1016 A L 0.466 Neutral MSH6 P52701 A1016M 1016 A M 0.352 Neutral MSH6 P52701 A1016N 1016 A N 0.356 Neutral MSH6 P52701 A1016P 1016 A P 0.304 Neutral MSH6 P52701 A1016Q 1016 A Q 0.32 Neutral MSH6 P52701 A1016R 1016 A R 0.376 Neutral MSH6 P52701 A1016S 1016 A S 0.004 Neutral MSH6 P52701 A1016T 1016 A T 0.018 Neutral MSH6 P52701 A1016V 1016 A V 0.274 Neutral MSH6 P52701 A1016W 1016 A W 0.572 Pathogenic MSH6 P52701 A1016Y 1016 A Y 0.57 Pathogenic MSH6 P52701 N1017A 1017 N A 0.004 Neutral MSH6 P52701 N1017C 1017 N C 0.148 Neutral MSH6 P52701 N1017D 1017 N D 0.008 Neutral MSH6 P52701 N1017E 1017 N E 0.012 Neutral MSH6 P52701 N1017F 1017 N F 0.34 Neutral MSH6 P52701 N1017G 1017 N G 0.162 Neutral MSH6 P52701 N1017H 1017 N H 0.262 Neutral MSH6 P52701 N1017I 1017 N I 0.266 Neutral MSH6 P52701 N1017K 1017 N K 0.038 Neutral MSH6 P52701 N1017L 1017 N L 0.314 Neutral MSH6 P52701 N1017M 1017 N M 0.22 Neutral MSH6 P52701 N1017P 1017 N P 0.248 Neutral MSH6 P52701 N1017Q 1017 N Q 0.014 Neutral MSH6 P52701 N1017R 1017 N R 0.164 Neutral MSH6 P52701 N1017S 1017 N S 0 Neutral MSH6 P52701 N1017T 1017 N T 0.142 Neutral MSH6 P52701 N1017V 1017 N V 0.28 Neutral MSH6 P52701 N1017W 1017 N W 0.446 Neutral MSH6 P52701 N1017Y 1017 N Y 0.402 Neutral MSH6 P52701 L1018A 1018 L A 0.13 Neutral MSH6 P52701 L1018C 1018 L C 0.132 Neutral MSH6 P52701 L1018D 1018 L D 0.236 Neutral MSH6 P52701 L1018E 1018 L E 0.218 Neutral MSH6 P52701 L1018F 1018 L F 0.356 Neutral MSH6 P52701 L1018G 1018 L G 0.256 Neutral MSH6 P52701 L1018H 1018 L H 0.124 Neutral MSH6 P52701 L1018I 1018 L I 0.042 Neutral MSH6 P52701 L1018K 1018 L K 0.164 Neutral MSH6 P52701 L1018M 1018 L M 0.008 Neutral MSH6 P52701 L1018N 1018 L N 0.232 Neutral MSH6 P52701 L1018P 1018 L P 0.33 Neutral MSH6 P52701 L1018Q 1018 L Q 0.01 Neutral MSH6 P52701 L1018R 1018 L R 0.492 Neutral MSH6 P52701 L1018S 1018 L S 0.186 Neutral MSH6 P52701 L1018T 1018 L T 0.112 Neutral MSH6 P52701 L1018V 1018 L V 0.17 Neutral MSH6 P52701 L1018W 1018 L W 0.52 Pathogenic MSH6 P52701 L1018Y 1018 L Y 0.506 Pathogenic MSH6 P52701 I1019A 1019 I A 0.032 Neutral MSH6 P52701 I1019C 1019 I C 0.182 Neutral MSH6 P52701 I1019D 1019 I D 0.364 Neutral MSH6 P52701 I1019E 1019 I E 0.048 Neutral MSH6 P52701 I1019F 1019 I F 0.42 Neutral MSH6 P52701 I1019G 1019 I G 0.344 Neutral MSH6 P52701 I1019H 1019 I H 0.184 Neutral MSH6 P52701 I1019K 1019 I K 0.348 Neutral MSH6 P52701 I1019L 1019 I L 0.006 Neutral MSH6 P52701 I1019M 1019 I M 0.03 Neutral MSH6 P52701 I1019N 1019 I N 0.34 Neutral MSH6 P52701 I1019P 1019 I P 0.328 Neutral MSH6 P52701 I1019Q 1019 I Q 0.108 Neutral MSH6 P52701 I1019R 1019 I R 0.568 Pathogenic MSH6 P52701 I1019S 1019 I S 0.434 Neutral MSH6 P52701 I1019T 1019 I T 0.014 Neutral MSH6 P52701 I1019V 1019 I V 0.004 Neutral MSH6 P52701 I1019W 1019 I W 0.638 Pathogenic MSH6 P52701 I1019Y 1019 I Y 0.6 Pathogenic MSH6 P52701 G102A 102 G A 0.16 Neutral MSH6 P52701 G102C 102 G C 0.36 Neutral MSH6 P52701 G102D 102 G D 0.426 Neutral MSH6 P52701 G102E 102 G E 0.56 Pathogenic MSH6 P52701 G102F 102 G F 0.758 Pathogenic MSH6 P52701 G102H 102 G H 0.7 Pathogenic MSH6 P52701 G102I 102 G I 0.676 Pathogenic MSH6 P52701 G102K 102 G K 0.682 Pathogenic MSH6 P52701 G102L 102 G L 0.674 Pathogenic MSH6 P52701 G102M 102 G M 0.69 Pathogenic MSH6 P52701 G102N 102 G N 0.422 Neutral MSH6 P52701 G102P 102 G P 0.634 Pathogenic MSH6 P52701 G102Q 102 G Q 0.45 Neutral MSH6 P52701 G102R 102 G R 0.75 Pathogenic MSH6 P52701 G102S 102 G S 0.278 Neutral MSH6 P52701 G102T 102 G T 0.48 Neutral MSH6 P52701 G102V 102 G V 0.652 Pathogenic MSH6 P52701 G102W 102 G W 0.758 Pathogenic MSH6 P52701 G102Y 102 G Y 0.744 Pathogenic MSH6 P52701 N1020A 1020 N A 0.056 Neutral MSH6 P52701 N1020C 1020 N C 0.542 Pathogenic MSH6 P52701 N1020D 1020 N D 0.024 Neutral MSH6 P52701 N1020E 1020 N E 0.034 Neutral MSH6 P52701 N1020F 1020 N F 0.842 Pathogenic MSH6 P52701 N1020G 1020 N G 0.062 Neutral MSH6 P52701 N1020H 1020 N H 0.048 Neutral MSH6 P52701 N1020I 1020 N I 0.4 Neutral MSH6 P52701 N1020K 1020 N K 0.062 Neutral MSH6 P52701 N1020L 1020 N L 0.176 Neutral MSH6 P52701 N1020M 1020 N M 0.76 Pathogenic MSH6 P52701 N1020P 1020 N P 0.7 Pathogenic MSH6 P52701 N1020Q 1020 N Q 0.02 Neutral MSH6 P52701 N1020R 1020 N R 0.412 Neutral MSH6 P52701 N1020S 1020 N S 0.038 Neutral MSH6 P52701 N1020T 1020 N T 0.024 Neutral MSH6 P52701 N1020V 1020 N V 0.216 Neutral MSH6 P52701 N1020W 1020 N W 0.914 Pathogenic MSH6 P52701 N1020Y 1020 N Y 0.892 Pathogenic MSH6 P52701 A1021C 1021 A C 0.396 Neutral MSH6 P52701 A1021D 1021 A D 0.84 Pathogenic MSH6 P52701 A1021E 1021 A E 0.582 Pathogenic MSH6 P52701 A1021F 1021 A F 0.568 Pathogenic MSH6 P52701 A1021G 1021 A G 0.146 Neutral MSH6 P52701 A1021H 1021 A H 0.852 Pathogenic MSH6 P52701 A1021I 1021 A I 0.92 Pathogenic MSH6 P52701 A1021K 1021 A K 0.898 Pathogenic MSH6 P52701 A1021L 1021 A L 0.582 Pathogenic MSH6 P52701 A1021M 1021 A M 0.814 Pathogenic MSH6 P52701 A1021N 1021 A N 0.762 Pathogenic MSH6 P52701 A1021P 1021 A P 0.928 Pathogenic MSH6 P52701 A1021Q 1021 A Q 0.506 Pathogenic MSH6 P52701 A1021R 1021 A R 0.658 Pathogenic MSH6 P52701 A1021S 1021 A S 0.362 Neutral MSH6 P52701 A1021T 1021 A T 0.046 Neutral MSH6 P52701 A1021V 1021 A V 0.16 Neutral MSH6 P52701 A1021W 1021 A W 0.644 Pathogenic MSH6 P52701 A1021Y 1021 A Y 0.918 Pathogenic MSH6 P52701 E1022A 1022 E A 0.358 Neutral MSH6 P52701 E1022C 1022 E C 0.738 Pathogenic MSH6 P52701 E1022D 1022 E D 0.234 Neutral MSH6 P52701 E1022F 1022 E F 0.944 Pathogenic MSH6 P52701 E1022G 1022 E G 0.334 Neutral MSH6 P52701 E1022H 1022 E H 0.684 Pathogenic MSH6 P52701 E1022I 1022 E I 0.79 Pathogenic MSH6 P52701 E1022K 1022 E K 0.368 Neutral MSH6 P52701 E1022L 1022 E L 0.698 Pathogenic MSH6 P52701 E1022M 1022 E M 0.886 Pathogenic MSH6 P52701 E1022N 1022 E N 0.752 Pathogenic MSH6 P52701 E1022P 1022 E P 0.924 Pathogenic MSH6 P52701 E1022Q 1022 E Q 0.826 Pathogenic MSH6 P52701 E1022R 1022 E R 0.594 Pathogenic MSH6 P52701 E1022S 1022 E S 0.312 Neutral MSH6 P52701 E1022T 1022 E T 0.81 Pathogenic MSH6 P52701 E1022V 1022 E V 0.908 Pathogenic MSH6 P52701 E1022W 1022 E W 0.974 Pathogenic MSH6 P52701 E1022Y 1022 E Y 0.886 Pathogenic MSH6 P52701 E1023A 1023 E A 0.224 Neutral MSH6 P52701 E1023C 1023 E C 0.454 Neutral MSH6 P52701 E1023D 1023 E D 0.028 Neutral MSH6 P52701 E1023F 1023 E F 0.834 Pathogenic MSH6 P52701 E1023G 1023 E G 0.206 Neutral MSH6 P52701 E1023H 1023 E H 0.592 Pathogenic MSH6 P52701 E1023I 1023 E I 0.222 Neutral MSH6 P52701 E1023K 1023 E K 0.174 Neutral MSH6 P52701 E1023L 1023 E L 0.146 Neutral MSH6 P52701 E1023M 1023 E M 0.182 Neutral MSH6 P52701 E1023N 1023 E N 0.03 Neutral MSH6 P52701 E1023P 1023 E P 0.862 Pathogenic MSH6 P52701 E1023Q 1023 E Q 0.084 Neutral MSH6 P52701 E1023R 1023 E R 0.532 Pathogenic MSH6 P52701 E1023S 1023 E S 0.05 Neutral MSH6 P52701 E1023T 1023 E T 0.054 Neutral MSH6 P52701 E1023V 1023 E V 0.744 Pathogenic MSH6 P52701 E1023W 1023 E W 0.968 Pathogenic MSH6 P52701 E1023Y 1023 E Y 0.9 Pathogenic MSH6 P52701 R1024A 1024 R A 0.13 Neutral MSH6 P52701 R1024C 1024 R C 0.614 Pathogenic MSH6 P52701 R1024D 1024 R D 0.052 Neutral MSH6 P52701 R1024E 1024 R E 0.046 Neutral MSH6 P52701 R1024F 1024 R F 0.866 Pathogenic MSH6 P52701 R1024G 1024 R G 0.144 Neutral MSH6 P52701 R1024H 1024 R H 0.04 Neutral MSH6 P52701 R1024I 1024 R I 0.88 Pathogenic MSH6 P52701 R1024K 1024 R K 0.056 Neutral MSH6 P52701 R1024L 1024 R L 0.242 Neutral MSH6 P52701 R1024M 1024 R M 0.38 Neutral MSH6 P52701 R1024N 1024 R N 0.534 Pathogenic MSH6 P52701 R1024P 1024 R P 0.794 Pathogenic MSH6 P52701 R1024Q 1024 R Q 0.026 Neutral MSH6 P52701 R1024S 1024 R S 0.208 Neutral MSH6 P52701 R1024T 1024 R T 0.052 Neutral MSH6 P52701 R1024V 1024 R V 0.152 Neutral MSH6 P52701 R1024W 1024 R W 0.86 Pathogenic MSH6 P52701 R1024Y 1024 R Y 0.194 Neutral MSH6 P52701 R1025A 1025 R A 0.428 Neutral MSH6 P52701 R1025C 1025 R C 0.676 Pathogenic MSH6 P52701 R1025D 1025 R D 0.644 Pathogenic MSH6 P52701 R1025E 1025 R E 0.564 Pathogenic MSH6 P52701 R1025F 1025 R F 0.936 Pathogenic MSH6 P52701 R1025G 1025 R G 0.212 Neutral MSH6 P52701 R1025H 1025 R H 0.51 Pathogenic MSH6 P52701 R1025I 1025 R I 0.908 Pathogenic MSH6 P52701 R1025K 1025 R K 0.036 Neutral MSH6 P52701 R1025L 1025 R L 0.118 Neutral MSH6 P52701 R1025M 1025 R M 0.688 Pathogenic MSH6 P52701 R1025N 1025 R N 0.504 Pathogenic MSH6 P52701 R1025P 1025 R P 0.846 Pathogenic MSH6 P52701 R1025Q 1025 R Q 0.068 Neutral MSH6 P52701 R1025S 1025 R S 0.448 Neutral MSH6 P52701 R1025T 1025 R T 0.554 Pathogenic MSH6 P52701 R1025V 1025 R V 0.826 Pathogenic MSH6 P52701 R1025W 1025 R W 0.912 Pathogenic MSH6 P52701 R1025Y 1025 R Y 0.9 Pathogenic MSH6 P52701 D1026A 1026 D A 0.13 Neutral MSH6 P52701 D1026C 1026 D C 0.716 Pathogenic MSH6 P52701 D1026E 1026 D E 0.052 Neutral MSH6 P52701 D1026F 1026 D F 0.888 Pathogenic MSH6 P52701 D1026G 1026 D G 0.074 Neutral MSH6 P52701 D1026H 1026 D H 0.434 Neutral MSH6 P52701 D1026I 1026 D I 0.838 Pathogenic MSH6 P52701 D1026K 1026 D K 0.086 Neutral MSH6 P52701 D1026L 1026 D L 0.148 Neutral MSH6 P52701 D1026M 1026 D M 0.778 Pathogenic MSH6 P52701 D1026N 1026 D N 0.024 Neutral MSH6 P52701 D1026P 1026 D P 0.794 Pathogenic MSH6 P52701 D1026Q 1026 D Q 0.034 Neutral MSH6 P52701 D1026R 1026 D R 0.588 Pathogenic MSH6 P52701 D1026S 1026 D S 0.026 Neutral MSH6 P52701 D1026T 1026 D T 0.084 Neutral MSH6 P52701 D1026V 1026 D V 0.9 Pathogenic MSH6 P52701 D1026W 1026 D W 0.968 Pathogenic MSH6 P52701 D1026Y 1026 D Y 0.964 Pathogenic MSH6 P52701 V1027A 1027 V A 0.02 Neutral MSH6 P52701 V1027C 1027 V C 0.306 Neutral MSH6 P52701 V1027D 1027 V D 0.076 Neutral MSH6 P52701 V1027E 1027 V E 0.088 Neutral MSH6 P52701 V1027F 1027 V F 0.6 Pathogenic MSH6 P52701 V1027G 1027 V G 0.594 Pathogenic MSH6 P52701 V1027H 1027 V H 0.242 Neutral MSH6 P52701 V1027I 1027 V I 0.028 Neutral MSH6 P52701 V1027K 1027 V K 0.12 Neutral MSH6 P52701 V1027L 1027 V L 0.072 Neutral MSH6 P52701 V1027M 1027 V M 0.04 Neutral MSH6 P52701 V1027N 1027 V N 0.086 Neutral MSH6 P52701 V1027P 1027 V P 0.69 Pathogenic MSH6 P52701 V1027Q 1027 V Q 0.106 Neutral MSH6 P52701 V1027R 1027 V R 0.734 Pathogenic MSH6 P52701 V1027S 1027 V S 0.036 Neutral MSH6 P52701 V1027T 1027 V T 0.02 Neutral MSH6 P52701 V1027W 1027 V W 0.716 Pathogenic MSH6 P52701 V1027Y 1027 V Y 0.688 Pathogenic MSH6 P52701 S1028A 1028 S A 0.05 Neutral MSH6 P52701 S1028C 1028 S C 0.258 Neutral MSH6 P52701 S1028D 1028 S D 0.382 Neutral MSH6 P52701 S1028E 1028 S E 0.74 Pathogenic MSH6 P52701 S1028F 1028 S F 0.8 Pathogenic MSH6 P52701 S1028G 1028 S G 0.232 Neutral MSH6 P52701 S1028H 1028 S H 0.806 Pathogenic MSH6 P52701 S1028I 1028 S I 0.376 Neutral MSH6 P52701 S1028K 1028 S K 0.462 Neutral MSH6 P52701 S1028L 1028 S L 0.154 Neutral MSH6 P52701 S1028M 1028 S M 0.902 Pathogenic MSH6 P52701 S1028N 1028 S N 0.438 Neutral MSH6 P52701 S1028P 1028 S P 0.604 Pathogenic MSH6 P52701 S1028Q 1028 S Q 0.502 Pathogenic MSH6 P52701 S1028R 1028 S R 0.594 Pathogenic MSH6 P52701 S1028T 1028 S T 0.674 Pathogenic MSH6 P52701 S1028V 1028 S V 0.086 Neutral MSH6 P52701 S1028W 1028 S W 0.952 Pathogenic MSH6 P52701 S1028Y 1028 S Y 0.932 Pathogenic MSH6 P52701 L1029A 1029 L A 0.118 Neutral MSH6 P52701 L1029C 1029 L C 0.414 Neutral MSH6 P52701 L1029D 1029 L D 0.662 Pathogenic MSH6 P52701 L1029E 1029 L E 0.414 Neutral MSH6 P52701 L1029F 1029 L F 0.758 Pathogenic MSH6 P52701 L1029G 1029 L G 0.128 Neutral MSH6 P52701 L1029H 1029 L H 0.444 Neutral MSH6 P52701 L1029I 1029 L I 0.054 Neutral MSH6 P52701 L1029K 1029 L K 0.07 Neutral MSH6 P52701 L1029M 1029 L M 0.018 Neutral MSH6 P52701 L1029N 1029 L N 0.608 Pathogenic MSH6 P52701 L1029P 1029 L P 0.896 Pathogenic MSH6 P52701 L1029Q 1029 L Q 0.042 Neutral MSH6 P52701 L1029R 1029 L R 0.558 Pathogenic MSH6 P52701 L1029S 1029 L S 0.068 Neutral MSH6 P52701 L1029T 1029 L T 0.03 Neutral MSH6 P52701 L1029V 1029 L V 0.004 Neutral MSH6 P52701 L1029W 1029 L W 0.82 Pathogenic MSH6 P52701 L1029Y 1029 L Y 0.806 Pathogenic MSH6 P52701 Y103A 103 Y A 0.11 Neutral MSH6 P52701 Y103C 103 Y C 0.152 Neutral MSH6 P52701 Y103D 103 Y D 0.26 Neutral MSH6 P52701 Y103E 103 Y E 0.254 Neutral MSH6 P52701 Y103F 103 Y F 0.062 Neutral MSH6 P52701 Y103G 103 Y G 0.15 Neutral MSH6 P52701 Y103H 103 Y H 0.012 Neutral MSH6 P52701 Y103I 103 Y I 0.144 Neutral MSH6 P52701 Y103K 103 Y K 0.244 Neutral MSH6 P52701 Y103L 103 Y L 0.082 Neutral MSH6 P52701 Y103M 103 Y M 0.13 Neutral MSH6 P52701 Y103N 103 Y N 0.174 Neutral MSH6 P52701 Y103P 103 Y P 0.122 Neutral MSH6 P52701 Y103Q 103 Y Q 0.164 Neutral MSH6 P52701 Y103R 103 Y R 0.234 Neutral MSH6 P52701 Y103S 103 Y S 0.152 Neutral MSH6 P52701 Y103T 103 Y T 0.154 Neutral MSH6 P52701 Y103V 103 Y V 0.216 Neutral MSH6 P52701 Y103W 103 Y W 0.066 Neutral MSH6 P52701 K1030A 1030 K A 0.108 Neutral MSH6 P52701 K1030C 1030 K C 0.436 Neutral MSH6 P52701 K1030D 1030 K D 0.08 Neutral MSH6 P52701 K1030E 1030 K E 0.144 Neutral MSH6 P52701 K1030F 1030 K F 0.962 Pathogenic MSH6 P52701 K1030G 1030 K G 0.54 Pathogenic MSH6 P52701 K1030H 1030 K H 0.13 Neutral MSH6 P52701 K1030I 1030 K I 0.988 Pathogenic MSH6 P52701 K1030L 1030 K L 0.36 Neutral MSH6 P52701 K1030M 1030 K M 0.918 Pathogenic MSH6 P52701 K1030N 1030 K N 0.656 Pathogenic MSH6 P52701 K1030P 1030 K P 0.922 Pathogenic MSH6 P52701 K1030Q 1030 K Q 0.102 Neutral MSH6 P52701 K1030R 1030 K R 0.126 Neutral MSH6 P52701 K1030S 1030 K S 0.148 Neutral MSH6 P52701 K1030T 1030 K T 0.172 Neutral MSH6 P52701 K1030V 1030 K V 0.874 Pathogenic MSH6 P52701 K1030W 1030 K W 0.992 Pathogenic MSH6 P52701 K1030Y 1030 K Y 0.984 Pathogenic MSH6 P52701 D1031A 1031 D A 0.132 Neutral MSH6 P52701 D1031C 1031 D C 0.19 Neutral MSH6 P52701 D1031E 1031 D E 0.036 Neutral MSH6 P52701 D1031F 1031 D F 0.95 Pathogenic MSH6 P52701 D1031G 1031 D G 0.06 Neutral MSH6 P52701 D1031H 1031 D H 0.434 Neutral MSH6 P52701 D1031I 1031 D I 0.92 Pathogenic MSH6 P52701 D1031K 1031 D K 0.714 Pathogenic MSH6 P52701 D1031L 1031 D L 0.918 Pathogenic MSH6 P52701 D1031M 1031 D M 0.83 Pathogenic MSH6 P52701 D1031N 1031 D N 0.014 Neutral MSH6 P52701 D1031P 1031 D P 0.706 Pathogenic MSH6 P52701 D1031Q 1031 D Q 0.15 Neutral MSH6 P52701 D1031R 1031 D R 0.48 Neutral MSH6 P52701 D1031S 1031 D S 0.01 Neutral MSH6 P52701 D1031T 1031 D T 0.122 Neutral MSH6 P52701 D1031V 1031 D V 0.942 Pathogenic MSH6 P52701 D1031W 1031 D W 0.968 Pathogenic MSH6 P52701 D1031Y 1031 D Y 0.96 Pathogenic MSH6 P52701 C1032A 1032 C A 0.072 Neutral MSH6 P52701 C1032D 1032 C D 0.456 Neutral MSH6 P52701 C1032E 1032 C E 0.574 Pathogenic MSH6 P52701 C1032F 1032 C F 0.746 Pathogenic MSH6 P52701 C1032G 1032 C G 0.032 Neutral MSH6 P52701 C1032H 1032 C H 0.7 Pathogenic MSH6 P52701 C1032I 1032 C I 0.13 Neutral MSH6 P52701 C1032K 1032 C K 0.626 Pathogenic MSH6 P52701 C1032L 1032 C L 0.086 Neutral MSH6 P52701 C1032M 1032 C M 0.108 Neutral MSH6 P52701 C1032N 1032 C N 0.176 Neutral MSH6 P52701 C1032P 1032 C P 0.828 Pathogenic MSH6 P52701 C1032Q 1032 C Q 0.026 Neutral MSH6 P52701 C1032R 1032 C R 0.836 Pathogenic MSH6 P52701 C1032S 1032 C S 0.086 Neutral MSH6 P52701 C1032T 1032 C T 0.008 Neutral MSH6 P52701 C1032V 1032 C V 0.066 Neutral MSH6 P52701 C1032W 1032 C W 0.918 Pathogenic MSH6 P52701 C1032Y 1032 C Y 0.924 Pathogenic MSH6 P52701 M1033A 1033 M A 0.116 Neutral MSH6 P52701 M1033C 1033 M C 0.19 Neutral MSH6 P52701 M1033D 1033 M D 0.61 Pathogenic MSH6 P52701 M1033E 1033 M E 0.362 Neutral MSH6 P52701 M1033F 1033 M F 0.218 Neutral MSH6 P52701 M1033G 1033 M G 0.326 Neutral MSH6 P52701 M1033H 1033 M H 0.422 Neutral MSH6 P52701 M1033I 1033 M I 0.532 Pathogenic MSH6 P52701 M1033K 1033 M K 0.62 Pathogenic MSH6 P52701 M1033L 1033 M L 0.04 Neutral MSH6 P52701 M1033N 1033 M N 0.104 Neutral MSH6 P52701 M1033P 1033 M P 0.872 Pathogenic MSH6 P52701 M1033Q 1033 M Q 0.024 Neutral MSH6 P52701 M1033R 1033 M R 0.114 Neutral MSH6 P52701 M1033S 1033 M S 0.042 Neutral MSH6 P52701 M1033T 1033 M T 0.03 Neutral MSH6 P52701 M1033V 1033 M V 0.286 Neutral MSH6 P52701 M1033W 1033 M W 0.958 Pathogenic MSH6 P52701 M1033Y 1033 M Y 0.872 Pathogenic MSH6 P52701 R1034A 1034 R A 0.126 Neutral MSH6 P52701 R1034C 1034 R C 0.484 Neutral MSH6 P52701 R1034D 1034 R D 0.056 Neutral MSH6 P52701 R1034E 1034 R E 0.108 Neutral MSH6 P52701 R1034F 1034 R F 0.934 Pathogenic MSH6 P52701 R1034G 1034 R G 0.026 Neutral MSH6 P52701 R1034H 1034 R H 0.424 Neutral MSH6 P52701 R1034I 1034 R I 0.902 Pathogenic MSH6 P52701 R1034K 1034 R K 0.034 Neutral MSH6 P52701 R1034L 1034 R L 0.356 Neutral MSH6 P52701 R1034M 1034 R M 0.68 Pathogenic MSH6 P52701 R1034N 1034 R N 0.5 Pathogenic MSH6 P52701 R1034P 1034 R P 0.844 Pathogenic MSH6 P52701 R1034Q 1034 R Q 0.014 Neutral MSH6 P52701 R1034S 1034 R S 0.054 Neutral MSH6 P52701 R1034T 1034 R T 0.084 Neutral MSH6 P52701 R1034V 1034 R V 0.358 Neutral MSH6 P52701 R1034W 1034 R W 0.912 Pathogenic MSH6 P52701 R1034Y 1034 R Y 0.894 Pathogenic MSH6 P52701 R1035A 1035 R A 0.276 Neutral MSH6 P52701 R1035C 1035 R C 0.242 Neutral MSH6 P52701 R1035D 1035 R D 0.394 Neutral MSH6 P52701 R1035E 1035 R E 0.236 Neutral MSH6 P52701 R1035F 1035 R F 0.954 Pathogenic MSH6 P52701 R1035G 1035 R G 0.146 Neutral MSH6 P52701 R1035H 1035 R H 0.364 Neutral MSH6 P52701 R1035I 1035 R I 0.446 Neutral MSH6 P52701 R1035K 1035 R K 0.348 Neutral MSH6 P52701 R1035L 1035 R L 0.406 Neutral MSH6 P52701 R1035M 1035 R M 0.786 Pathogenic MSH6 P52701 R1035N 1035 R N 0.142 Neutral MSH6 P52701 R1035P 1035 R P 0.972 Pathogenic MSH6 P52701 R1035Q 1035 R Q 0.35 Neutral MSH6 P52701 R1035S 1035 R S 0.372 Neutral MSH6 P52701 R1035T 1035 R T 0.188 Neutral MSH6 P52701 R1035V 1035 R V 0.668 Pathogenic MSH6 P52701 R1035W 1035 R W 0.964 Pathogenic MSH6 P52701 R1035Y 1035 R Y 0.958 Pathogenic MSH6 P52701 L1036A 1036 L A 0.116 Neutral MSH6 P52701 L1036C 1036 L C 0.414 Neutral MSH6 P52701 L1036D 1036 L D 0.66 Pathogenic MSH6 P52701 L1036E 1036 L E 0.62 Pathogenic MSH6 P52701 L1036F 1036 L F 0.286 Neutral MSH6 P52701 L1036G 1036 L G 0.57 Pathogenic MSH6 P52701 L1036H 1036 L H 0.446 Neutral MSH6 P52701 L1036I 1036 L I 0.052 Neutral MSH6 P52701 L1036K 1036 L K 0.442 Neutral MSH6 P52701 L1036M 1036 L M 0.028 Neutral MSH6 P52701 L1036N 1036 L N 0.46 Neutral MSH6 P52701 L1036P 1036 L P 0.882 Pathogenic MSH6 P52701 L1036Q 1036 L Q 0.382 Neutral MSH6 P52701 L1036R 1036 L R 0.856 Pathogenic MSH6 P52701 L1036S 1036 L S 0.35 Neutral MSH6 P52701 L1036T 1036 L T 0.334 Neutral MSH6 P52701 L1036V 1036 L V 0.01 Neutral MSH6 P52701 L1036W 1036 L W 0.81 Pathogenic MSH6 P52701 L1036Y 1036 L Y 0.796 Pathogenic MSH6 P52701 F1037A 1037 F A 0.422 Neutral MSH6 P52701 F1037C 1037 F C 0.114 Neutral MSH6 P52701 F1037D 1037 F D 0.45 Neutral MSH6 P52701 F1037E 1037 F E 0.894 Pathogenic MSH6 P52701 F1037G 1037 F G 0.492 Neutral MSH6 P52701 F1037H 1037 F H 0.126 Neutral MSH6 P52701 F1037I 1037 F I 0.118 Neutral MSH6 P52701 F1037K 1037 F K 0.862 Pathogenic MSH6 P52701 F1037L 1037 F L 0.146 Neutral MSH6 P52701 F1037M 1037 F M 0.664 Pathogenic MSH6 P52701 F1037N 1037 F N 0.732 Pathogenic MSH6 P52701 F1037P 1037 F P 0.924 Pathogenic MSH6 P52701 F1037Q 1037 F Q 0.17 Neutral MSH6 P52701 F1037R 1037 F R 0.932 Pathogenic MSH6 P52701 F1037S 1037 F S 0.408 Neutral MSH6 P52701 F1037T 1037 F T 0.21 Neutral MSH6 P52701 F1037V 1037 F V 0.792 Pathogenic MSH6 P52701 F1037W 1037 F W 0.914 Pathogenic MSH6 P52701 F1037Y 1037 F Y 0.236 Neutral MSH6 P52701 Y1038A 1038 Y A 0.104 Neutral MSH6 P52701 Y1038C 1038 Y C 0.338 Neutral MSH6 P52701 Y1038D 1038 Y D 0.57 Pathogenic MSH6 P52701 Y1038E 1038 Y E 0.078 Neutral MSH6 P52701 Y1038F 1038 Y F 0.026 Neutral MSH6 P52701 Y1038G 1038 Y G 0.158 Neutral MSH6 P52701 Y1038H 1038 Y H 0.026 Neutral MSH6 P52701 Y1038I 1038 Y I 0.31 Neutral MSH6 P52701 Y1038K 1038 Y K 0.054 Neutral MSH6 P52701 Y1038L 1038 Y L 0.208 Neutral MSH6 P52701 Y1038M 1038 Y M 0.306 Neutral MSH6 P52701 Y1038N 1038 Y N 0.378 Neutral MSH6 P52701 Y1038P 1038 Y P 0.324 Neutral MSH6 P52701 Y1038Q 1038 Y Q 0.104 Neutral MSH6 P52701 Y1038R 1038 Y R 0.082 Neutral MSH6 P52701 Y1038S 1038 Y S 0.156 Neutral MSH6 P52701 Y1038T 1038 Y T 0.164 Neutral MSH6 P52701 Y1038V 1038 Y V 0.038 Neutral MSH6 P52701 Y1038W 1038 Y W 0.328 Neutral MSH6 P52701 N1039A 1039 N A 0.36 Neutral MSH6 P52701 N1039C 1039 N C 0.584 Pathogenic MSH6 P52701 N1039D 1039 N D 0.036 Neutral MSH6 P52701 N1039E 1039 N E 0.082 Neutral MSH6 P52701 N1039F 1039 N F 0.91 Pathogenic MSH6 P52701 N1039G 1039 N G 0.612 Pathogenic MSH6 P52701 N1039H 1039 N H 0.754 Pathogenic MSH6 P52701 N1039I 1039 N I 0.87 Pathogenic MSH6 P52701 N1039K 1039 N K 0.096 Neutral MSH6 P52701 N1039L 1039 N L 0.178 Neutral MSH6 P52701 N1039M 1039 N M 0.832 Pathogenic MSH6 P52701 N1039P 1039 N P 0.754 Pathogenic MSH6 P52701 N1039Q 1039 N Q 0.034 Neutral MSH6 P52701 N1039R 1039 N R 0.44 Neutral MSH6 P52701 N1039S 1039 N S 0.044 Neutral MSH6 P52701 N1039T 1039 N T 0.134 Neutral MSH6 P52701 N1039V 1039 N V 0.902 Pathogenic MSH6 P52701 N1039W 1039 N W 0.954 Pathogenic MSH6 P52701 N1039Y 1039 N Y 0.946 Pathogenic MSH6 P52701 P104A 104 P A 0.242 Neutral MSH6 P52701 P104C 104 P C 0.226 Neutral MSH6 P52701 P104D 104 P D 0.126 Neutral MSH6 P52701 P104E 104 P E 0.352 Neutral MSH6 P52701 P104F 104 P F 0.508 Pathogenic MSH6 P52701 P104G 104 P G 0.132 Neutral MSH6 P52701 P104H 104 P H 0.47 Neutral MSH6 P52701 P104I 104 P I 0.204 Neutral MSH6 P52701 P104K 104 P K 0.346 Neutral MSH6 P52701 P104L 104 P L 0.162 Neutral MSH6 P52701 P104M 104 P M 0.37 Neutral MSH6 P52701 P104N 104 P N 0.1 Neutral MSH6 P52701 P104Q 104 P Q 0.358 Neutral MSH6 P52701 P104R 104 P R 0.524 Pathogenic MSH6 P52701 P104S 104 P S 0.16 Neutral MSH6 P52701 P104T 104 P T 0.178 Neutral MSH6 P52701 P104V 104 P V 0.206 Neutral MSH6 P52701 P104W 104 P W 0.602 Pathogenic MSH6 P52701 P104Y 104 P Y 0.532 Pathogenic MSH6 P52701 F1040A 1040 F A 0.492 Neutral MSH6 P52701 F1040C 1040 F C 0.724 Pathogenic MSH6 P52701 F1040D 1040 F D 0.81 Pathogenic MSH6 P52701 F1040E 1040 F E 0.864 Pathogenic MSH6 P52701 F1040G 1040 F G 0.498 Neutral MSH6 P52701 F1040H 1040 F H 0.768 Pathogenic MSH6 P52701 F1040I 1040 F I 0.69 Pathogenic MSH6 P52701 F1040K 1040 F K 0.844 Pathogenic MSH6 P52701 F1040L 1040 F L 0.704 Pathogenic MSH6 P52701 F1040M 1040 F M 0.784 Pathogenic MSH6 P52701 F1040N 1040 F N 0.76 Pathogenic MSH6 P52701 F1040P 1040 F P 0.95 Pathogenic MSH6 P52701 F1040Q 1040 F Q 0.782 Pathogenic MSH6 P52701 F1040R 1040 F R 0.912 Pathogenic MSH6 P52701 F1040S 1040 F S 0.864 Pathogenic MSH6 P52701 F1040T 1040 F T 0.588 Pathogenic MSH6 P52701 F1040V 1040 F V 0.746 Pathogenic MSH6 P52701 F1040W 1040 F W 0.868 Pathogenic MSH6 P52701 F1040Y 1040 F Y 0.574 Pathogenic MSH6 P52701 D1041A 1041 D A 0.316 Neutral MSH6 P52701 D1041C 1041 D C 0.196 Neutral MSH6 P52701 D1041E 1041 D E 0.904 Pathogenic MSH6 P52701 D1041F 1041 D F 0.976 Pathogenic MSH6 P52701 D1041G 1041 D G 0.178 Neutral MSH6 P52701 D1041H 1041 D H 0.568 Pathogenic MSH6 P52701 D1041I 1041 D I 0.556 Pathogenic MSH6 P52701 D1041K 1041 D K 0.922 Pathogenic MSH6 P52701 D1041L 1041 D L 0.964 Pathogenic MSH6 P52701 D1041M 1041 D M 0.918 Pathogenic MSH6 P52701 D1041N 1041 D N 0.22 Neutral MSH6 P52701 D1041P 1041 D P 0.886 Pathogenic MSH6 P52701 D1041Q 1041 D Q 0.742 Pathogenic MSH6 P52701 D1041R 1041 D R 0.886 Pathogenic MSH6 P52701 D1041S 1041 D S 0.116 Neutral MSH6 P52701 D1041T 1041 D T 0.792 Pathogenic MSH6 P52701 D1041V 1041 D V 0.35 Neutral MSH6 P52701 D1041W 1041 D W 0.98 Pathogenic MSH6 P52701 D1041Y 1041 D Y 0.816 Pathogenic MSH6 P52701 K1042A 1042 K A 0.1 Neutral MSH6 P52701 K1042C 1042 K C 0.18 Neutral MSH6 P52701 K1042D 1042 K D 0.038 Neutral MSH6 P52701 K1042E 1042 K E 0.086 Neutral MSH6 P52701 K1042F 1042 K F 0.804 Pathogenic MSH6 P52701 K1042G 1042 K G 0.278 Neutral MSH6 P52701 K1042H 1042 K H 0.034 Neutral MSH6 P52701 K1042I 1042 K I 0.762 Pathogenic MSH6 P52701 K1042L 1042 K L 0.242 Neutral MSH6 P52701 K1042M 1042 K M 0.156 Neutral MSH6 P52701 K1042N 1042 K N 0.048 Neutral MSH6 P52701 K1042P 1042 K P 0.8 Pathogenic MSH6 P52701 K1042Q 1042 K Q 0.052 Neutral MSH6 P52701 K1042R 1042 K R 0.048 Neutral MSH6 P52701 K1042S 1042 K S 0.04 Neutral MSH6 P52701 K1042T 1042 K T 0.046 Neutral MSH6 P52701 K1042V 1042 K V 0.112 Neutral MSH6 P52701 K1042W 1042 K W 0.976 Pathogenic MSH6 P52701 K1042Y 1042 K Y 0.92 Pathogenic MSH6 P52701 N1043A 1043 N A 0.362 Neutral MSH6 P52701 N1043C 1043 N C 0.584 Pathogenic MSH6 P52701 N1043D 1043 N D 0.03 Neutral MSH6 P52701 N1043E 1043 N E 0.592 Pathogenic MSH6 P52701 N1043F 1043 N F 0.912 Pathogenic MSH6 P52701 N1043G 1043 N G 0.514 Pathogenic MSH6 P52701 N1043H 1043 N H 0.078 Neutral MSH6 P52701 N1043I 1043 N I 0.87 Pathogenic MSH6 P52701 N1043K 1043 N K 0.098 Neutral MSH6 P52701 N1043L 1043 N L 0.866 Pathogenic MSH6 P52701 N1043M 1043 N M 0.244 Neutral MSH6 P52701 N1043P 1043 N P 0.754 Pathogenic MSH6 P52701 N1043Q 1043 N Q 0.61 Pathogenic MSH6 P52701 N1043R 1043 N R 0.454 Neutral MSH6 P52701 N1043S 1043 N S 0.05 Neutral MSH6 P52701 N1043T 1043 N T 0.308 Neutral MSH6 P52701 N1043V 1043 N V 0.902 Pathogenic MSH6 P52701 N1043W 1043 N W 0.954 Pathogenic MSH6 P52701 N1043Y 1043 N Y 0.716 Pathogenic MSH6 P52701 Y1044A 1044 Y A 0.164 Neutral MSH6 P52701 Y1044C 1044 Y C 0.52 Pathogenic MSH6 P52701 Y1044D 1044 Y D 0.804 Pathogenic MSH6 P52701 Y1044E 1044 Y E 0.756 Pathogenic MSH6 P52701 Y1044F 1044 Y F 0.098 Neutral MSH6 P52701 Y1044G 1044 Y G 0.374 Neutral MSH6 P52701 Y1044H 1044 Y H 0.108 Neutral MSH6 P52701 Y1044I 1044 Y I 0.606 Pathogenic MSH6 P52701 Y1044K 1044 Y K 0.268 Neutral MSH6 P52701 Y1044L 1044 Y L 0.502 Pathogenic MSH6 P52701 Y1044M 1044 Y M 0.58 Pathogenic MSH6 P52701 Y1044N 1044 Y N 0.204 Neutral MSH6 P52701 Y1044P 1044 Y P 0.636 Pathogenic MSH6 P52701 Y1044Q 1044 Y Q 0.188 Neutral MSH6 P52701 Y1044R 1044 Y R 0.182 Neutral MSH6 P52701 Y1044S 1044 Y S 0.19 Neutral MSH6 P52701 Y1044T 1044 Y T 0.52 Pathogenic MSH6 P52701 Y1044V 1044 Y V 0.388 Neutral MSH6 P52701 Y1044W 1044 Y W 0.686 Pathogenic MSH6 P52701 K1045A 1045 K A 0.042 Neutral MSH6 P52701 K1045C 1045 K C 0.11 Neutral MSH6 P52701 K1045D 1045 K D 0.004 Neutral MSH6 P52701 K1045E 1045 K E 0.006 Neutral MSH6 P52701 K1045F 1045 K F 0.278 Neutral MSH6 P52701 K1045G 1045 K G 0.198 Neutral MSH6 P52701 K1045H 1045 K H 0.154 Neutral MSH6 P52701 K1045I 1045 K I 0.094 Neutral MSH6 P52701 K1045L 1045 K L 0.084 Neutral MSH6 P52701 K1045M 1045 K M 0.358 Neutral MSH6 P52701 K1045N 1045 K N 0.012 Neutral MSH6 P52701 K1045P 1045 K P 0.05 Neutral MSH6 P52701 K1045Q 1045 K Q 0.016 Neutral MSH6 P52701 K1045R 1045 K R 0.008 Neutral MSH6 P52701 K1045S 1045 K S 0.03 Neutral MSH6 P52701 K1045T 1045 K T 0.036 Neutral MSH6 P52701 K1045V 1045 K V 0.306 Neutral MSH6 P52701 K1045W 1045 K W 0.804 Pathogenic MSH6 P52701 K1045Y 1045 K Y 0.7 Pathogenic MSH6 P52701 D1046A 1046 D A 0.202 Neutral MSH6 P52701 D1046C 1046 D C 0.382 Neutral MSH6 P52701 D1046E 1046 D E 0.022 Neutral MSH6 P52701 D1046F 1046 D F 0.68 Pathogenic MSH6 P52701 D1046G 1046 D G 0.306 Neutral MSH6 P52701 D1046H 1046 D H 0.046 Neutral MSH6 P52701 D1046I 1046 D I 0.142 Neutral MSH6 P52701 D1046K 1046 D K 0.026 Neutral MSH6 P52701 D1046L 1046 D L 0.056 Neutral MSH6 P52701 D1046M 1046 D M 0.056 Neutral MSH6 P52701 D1046N 1046 D N 0.004 Neutral MSH6 P52701 D1046P 1046 D P 0.538 Pathogenic MSH6 P52701 D1046Q 1046 D Q 0.02 Neutral MSH6 P52701 D1046R 1046 D R 0.398 Neutral MSH6 P52701 D1046S 1046 D S 0.012 Neutral MSH6 P52701 D1046T 1046 D T 0.028 Neutral MSH6 P52701 D1046V 1046 D V 0.086 Neutral MSH6 P52701 D1046W 1046 D W 0.802 Pathogenic MSH6 P52701 D1046Y 1046 D Y 0.526 Pathogenic MSH6 P52701 W1047A 1047 W A 0.476 Neutral MSH6 P52701 W1047C 1047 W C 0.48 Neutral MSH6 P52701 W1047D 1047 W D 0.51 Pathogenic MSH6 P52701 W1047E 1047 W E 0.85 Pathogenic MSH6 P52701 W1047F 1047 W F 0.39 Neutral MSH6 P52701 W1047G 1047 W G 0.476 Neutral MSH6 P52701 W1047H 1047 W H 0.728 Pathogenic MSH6 P52701 W1047I 1047 W I 0.546 Pathogenic MSH6 P52701 W1047K 1047 W K 0.904 Pathogenic MSH6 P52701 W1047L 1047 W L 0.488 Neutral MSH6 P52701 W1047M 1047 W M 0.726 Pathogenic MSH6 P52701 W1047N 1047 W N 0.486 Neutral MSH6 P52701 W1047P 1047 W P 0.508 Pathogenic MSH6 P52701 W1047Q 1047 W Q 0.66 Pathogenic MSH6 P52701 W1047R 1047 W R 0.744 Pathogenic MSH6 P52701 W1047S 1047 W S 0.486 Neutral MSH6 P52701 W1047T 1047 W T 0.378 Neutral MSH6 P52701 W1047V 1047 W V 0.416 Neutral MSH6 P52701 W1047Y 1047 W Y 0.716 Pathogenic MSH6 P52701 Q1048A 1048 Q A 0.106 Neutral MSH6 P52701 Q1048C 1048 Q C 0.372 Neutral MSH6 P52701 Q1048D 1048 Q D 0.028 Neutral MSH6 P52701 Q1048E 1048 Q E 0.04 Neutral MSH6 P52701 Q1048F 1048 Q F 0.73 Pathogenic MSH6 P52701 Q1048G 1048 Q G 0.424 Neutral MSH6 P52701 Q1048H 1048 Q H 0.074 Neutral MSH6 P52701 Q1048I 1048 Q I 0.31 Neutral MSH6 P52701 Q1048K 1048 Q K 0.05 Neutral MSH6 P52701 Q1048L 1048 Q L 0.178 Neutral MSH6 P52701 Q1048M 1048 Q M 0.06 Neutral MSH6 P52701 Q1048N 1048 Q N 0.062 Neutral MSH6 P52701 Q1048P 1048 Q P 0.79 Pathogenic MSH6 P52701 Q1048R 1048 Q R 0.036 Neutral MSH6 P52701 Q1048S 1048 Q S 0.086 Neutral MSH6 P52701 Q1048T 1048 Q T 0.04 Neutral MSH6 P52701 Q1048V 1048 Q V 0.392 Neutral MSH6 P52701 Q1048W 1048 Q W 0.874 Pathogenic MSH6 P52701 Q1048Y 1048 Q Y 0.898 Pathogenic MSH6 P52701 S1049A 1049 S A 0.054 Neutral MSH6 P52701 S1049C 1049 S C 0.27 Neutral MSH6 P52701 S1049D 1049 S D 0.36 Neutral MSH6 P52701 S1049E 1049 S E 0.41 Neutral MSH6 P52701 S1049F 1049 S F 0.804 Pathogenic MSH6 P52701 S1049G 1049 S G 0.038 Neutral MSH6 P52701 S1049H 1049 S H 0.732 Pathogenic MSH6 P52701 S1049I 1049 S I 0.554 Pathogenic MSH6 P52701 S1049K 1049 S K 0.404 Neutral MSH6 P52701 S1049L 1049 S L 0.142 Neutral MSH6 P52701 S1049M 1049 S M 0.556 Pathogenic MSH6 P52701 S1049N 1049 S N 0.088 Neutral MSH6 P52701 S1049P 1049 S P 0.528 Pathogenic MSH6 P52701 S1049Q 1049 S Q 0.418 Neutral MSH6 P52701 S1049R 1049 S R 0.43 Neutral MSH6 P52701 S1049T 1049 S T 0.04 Neutral MSH6 P52701 S1049V 1049 S V 0.432 Neutral MSH6 P52701 S1049W 1049 S W 0.924 Pathogenic MSH6 P52701 S1049Y 1049 S Y 0.898 Pathogenic MSH6 P52701 W105A 105 W A 0.128 Neutral MSH6 P52701 W105C 105 W C 0.128 Neutral MSH6 P52701 W105D 105 W D 0.19 Neutral MSH6 P52701 W105E 105 W E 0.24 Neutral MSH6 P52701 W105F 105 W F 0.044 Neutral MSH6 P52701 W105G 105 W G 0.138 Neutral MSH6 P52701 W105H 105 W H 0.128 Neutral MSH6 P52701 W105I 105 W I 0.13 Neutral MSH6 P52701 W105K 105 W K 0.234 Neutral MSH6 P52701 W105L 105 W L 0.094 Neutral MSH6 P52701 W105M 105 W M 0.122 Neutral MSH6 P52701 W105N 105 W N 0.138 Neutral MSH6 P52701 W105P 105 W P 0.146 Neutral MSH6 P52701 W105Q 105 W Q 0.138 Neutral MSH6 P52701 W105R 105 W R 0.228 Neutral MSH6 P52701 W105S 105 W S 0.144 Neutral MSH6 P52701 W105T 105 W T 0.128 Neutral MSH6 P52701 W105V 105 W V 0.15 Neutral MSH6 P52701 W105Y 105 W Y 0.194 Neutral MSH6 P52701 A1050C 1050 A C 0.37 Neutral MSH6 P52701 A1050D 1050 A D 0.928 Pathogenic MSH6 P52701 A1050E 1050 A E 0.956 Pathogenic MSH6 P52701 A1050F 1050 A F 0.982 Pathogenic MSH6 P52701 A1050G 1050 A G 0.734 Pathogenic MSH6 P52701 A1050H 1050 A H 0.912 Pathogenic MSH6 P52701 A1050I 1050 A I 0.918 Pathogenic MSH6 P52701 A1050K 1050 A K 0.95 Pathogenic MSH6 P52701 A1050L 1050 A L 0.698 Pathogenic MSH6 P52701 A1050M 1050 A M 0.622 Pathogenic MSH6 P52701 A1050N 1050 A N 0.868 Pathogenic MSH6 P52701 A1050P 1050 A P 0.956 Pathogenic MSH6 P52701 A1050Q 1050 A Q 0.892 Pathogenic MSH6 P52701 A1050R 1050 A R 0.958 Pathogenic MSH6 P52701 A1050S 1050 A S 0.134 Neutral MSH6 P52701 A1050T 1050 A T 0.212 Neutral MSH6 P52701 A1050V 1050 A V 0.444 Neutral MSH6 P52701 A1050W 1050 A W 0.982 Pathogenic MSH6 P52701 A1050Y 1050 A Y 0.948 Pathogenic MSH6 P52701 V1051A 1051 V A 0.098 Neutral MSH6 P52701 V1051C 1051 V C 0.352 Neutral MSH6 P52701 V1051D 1051 V D 0.862 Pathogenic MSH6 P52701 V1051E 1051 V E 0.978 Pathogenic MSH6 P52701 V1051F 1051 V F 0.876 Pathogenic MSH6 P52701 V1051G 1051 V G 0.892 Pathogenic MSH6 P52701 V1051H 1051 V H 0.82 Pathogenic MSH6 P52701 V1051I 1051 V I 0.16 Neutral MSH6 P52701 V1051K 1051 V K 0.99 Pathogenic MSH6 P52701 V1051L 1051 V L 0.242 Neutral MSH6 P52701 V1051M 1051 V M 0.232 Neutral MSH6 P52701 V1051N 1051 V N 0.552 Pathogenic MSH6 P52701 V1051P 1051 V P 0.984 Pathogenic MSH6 P52701 V1051Q 1051 V Q 0.984 Pathogenic MSH6 P52701 V1051R 1051 V R 0.952 Pathogenic MSH6 P52701 V1051S 1051 V S 0.72 Pathogenic MSH6 P52701 V1051T 1051 V T 0.108 Neutral MSH6 P52701 V1051W 1051 V W 0.904 Pathogenic MSH6 P52701 V1051Y 1051 V Y 0.928 Pathogenic MSH6 P52701 E1052A 1052 E A 0.59 Pathogenic MSH6 P52701 E1052C 1052 E C 0.424 Neutral MSH6 P52701 E1052D 1052 E D 0.016 Neutral MSH6 P52701 E1052F 1052 E F 0.798 Pathogenic MSH6 P52701 E1052G 1052 E G 0.044 Neutral MSH6 P52701 E1052H 1052 E H 0.052 Neutral MSH6 P52701 E1052I 1052 E I 0.864 Pathogenic MSH6 P52701 E1052K 1052 E K 0.036 Neutral MSH6 P52701 E1052L 1052 E L 0.846 Pathogenic MSH6 P52701 E1052M 1052 E M 0.658 Pathogenic MSH6 P52701 E1052N 1052 E N 0.018 Neutral MSH6 P52701 E1052P 1052 E P 0.86 Pathogenic MSH6 P52701 E1052Q 1052 E Q 0.012 Neutral MSH6 P52701 E1052R 1052 E R 0.1 Neutral MSH6 P52701 E1052S 1052 E S 0.03 Neutral MSH6 P52701 E1052T 1052 E T 0.602 Pathogenic MSH6 P52701 E1052V 1052 E V 0.818 Pathogenic MSH6 P52701 E1052W 1052 E W 0.934 Pathogenic MSH6 P52701 E1052Y 1052 E Y 0.344 Neutral MSH6 P52701 C1053A 1053 C A 0.044 Neutral MSH6 P52701 C1053D 1053 C D 0.526 Pathogenic MSH6 P52701 C1053E 1053 C E 0.598 Pathogenic MSH6 P52701 C1053F 1053 C F 0.926 Pathogenic MSH6 P52701 C1053G 1053 C G 0.51 Pathogenic MSH6 P52701 C1053H 1053 C H 0.756 Pathogenic MSH6 P52701 C1053I 1053 C I 0.132 Neutral MSH6 P52701 C1053K 1053 C K 0.114 Neutral MSH6 P52701 C1053L 1053 C L 0.106 Neutral MSH6 P52701 C1053M 1053 C M 0.354 Neutral MSH6 P52701 C1053N 1053 C N 0.058 Neutral MSH6 P52701 C1053P 1053 C P 0.87 Pathogenic MSH6 P52701 C1053Q 1053 C Q 0.458 Neutral MSH6 P52701 C1053R 1053 C R 0.56 Pathogenic MSH6 P52701 C1053S 1053 C S 0.03 Neutral MSH6 P52701 C1053T 1053 C T 0.014 Neutral MSH6 P52701 C1053V 1053 C V 0.06 Neutral MSH6 P52701 C1053W 1053 C W 0.948 Pathogenic MSH6 P52701 C1053Y 1053 C Y 0.918 Pathogenic MSH6 P52701 I1054A 1054 I A 0.164 Neutral MSH6 P52701 I1054C 1054 I C 0.282 Neutral MSH6 P52701 I1054D 1054 I D 0.616 Pathogenic MSH6 P52701 I1054E 1054 I E 0.598 Pathogenic MSH6 P52701 I1054F 1054 I F 0.148 Neutral 2 MSH6 P52701 I1054G 1054 I G 0.594 Pathogenic MSH6 P52701 I1054H 1054 I H 0.486 Neutral MSH6 P52701 I1054K 1054 I K 0.612 Pathogenic MSH6 P52701 I1054L 1054 I L 0.008 Neutral MSH6 P52701 I1054M 1054 I M 0.05 Neutral MSH6 P52701 I1054N 1054 I N 0.66 Pathogenic MSH6 P52701 I1054P 1054 I P 0.764 Pathogenic MSH6 P52701 I1054Q 1054 I Q 0.634 Pathogenic MSH6 P52701 I1054R 1054 I R 0.83 Pathogenic MSH6 P52701 I1054S 1054 I S 0.458 Neutral MSH6 P52701 I1054T 1054 I T 0.026 Neutral MSH6 P52701 I1054V 1054 I V 0.006 Neutral MSH6 P52701 I1054W 1054 I W 0.9 Pathogenic MSH6 P52701 I1054Y 1054 I Y 0.898 Pathogenic MSH6 P52701 A1055C 1055 A C 0.952 Pathogenic MSH6 P52701 A1055D 1055 A D 0.754 Pathogenic MSH6 P52701 A1055E 1055 A E 0.952 Pathogenic MSH6 P52701 A1055F 1055 A F 0.988 Pathogenic MSH6 P52701 A1055G 1055 A G 0.126 Neutral MSH6 P52701 A1055H 1055 A H 0.924 Pathogenic MSH6 P52701 A1055I 1055 A I 0.966 Pathogenic MSH6 P52701 A1055K 1055 A K 0.966 Pathogenic MSH6 P52701 A1055L 1055 A L 0.994 Pathogenic MSH6 P52701 A1055M 1055 A M 0.898 Pathogenic MSH6 P52701 A1055N 1055 A N 0.862 Pathogenic MSH6 P52701 A1055P 1055 A P 0.974 Pathogenic MSH6 P52701 A1055Q 1055 A Q 0.87 Pathogenic MSH6 P52701 A1055R 1055 A R 0.968 Pathogenic MSH6 P52701 A1055S 1055 A S 0.112 Neutral MSH6 P52701 A1055T 1055 A T 0.198 Neutral MSH6 P52701 A1055V 1055 A V 0.934 Pathogenic MSH6 P52701 A1055W 1055 A W 0.99 Pathogenic MSH6 P52701 A1055Y 1055 A Y 0.97 Pathogenic MSH6 P52701 V1056A 1056 V A 0.116 Neutral MSH6 P52701 V1056C 1056 V C 0.272 Neutral MSH6 P52701 V1056D 1056 V D 0.548 Pathogenic MSH6 P52701 V1056E 1056 V E 0.116 Neutral MSH6 P52701 V1056F 1056 V F 0.744 Pathogenic MSH6 P52701 V1056G 1056 V G 0.516 Pathogenic MSH6 P52701 V1056H 1056 V H 0.196 Neutral MSH6 P52701 V1056I 1056 V I 0.086 Neutral MSH6 P52701 V1056K 1056 V K 0.658 Pathogenic MSH6 P52701 V1056L 1056 V L 0.066 Neutral MSH6 P52701 V1056M 1056 V M 0.074 Neutral MSH6 P52701 V1056N 1056 V N 0.088 Neutral MSH6 P52701 V1056P 1056 V P 0.812 Pathogenic MSH6 P52701 V1056Q 1056 V Q 0.132 Neutral MSH6 P52701 V1056R 1056 V R 0.834 Pathogenic MSH6 P52701 V1056S 1056 V S 0.052 Neutral MSH6 P52701 V1056T 1056 V T 0.036 Neutral MSH6 P52701 V1056W 1056 V W 0.822 Pathogenic MSH6 P52701 V1056Y 1056 V Y 0.674 Pathogenic MSH6 P52701 L1057A 1057 L A 0.564 Pathogenic MSH6 P52701 L1057C 1057 L C 0.684 Pathogenic MSH6 P52701 L1057D 1057 L D 0.898 Pathogenic MSH6 P52701 L1057E 1057 L E 0.878 Pathogenic MSH6 P52701 L1057F 1057 L F 0.468 Neutral MSH6 P52701 L1057G 1057 L G 0.8 Pathogenic MSH6 P52701 L1057H 1057 L H 0.8 Pathogenic MSH6 P52701 L1057I 1057 L I 0.166 Neutral MSH6 P52701 L1057K 1057 L K 0.742 Pathogenic MSH6 P52701 L1057M 1057 L M 0.454 Neutral MSH6 P52701 L1057N 1057 L N 0.768 Pathogenic MSH6 P52701 L1057P 1057 L P 0.994 Pathogenic MSH6 P52701 L1057Q 1057 L Q 0.616 Pathogenic MSH6 P52701 L1057R 1057 L R 0.996 Pathogenic MSH6 P52701 L1057S 1057 L S 0.334 Neutral MSH6 P52701 L1057T 1057 L T 0.326 Neutral MSH6 P52701 L1057V 1057 L V 0.096 Neutral MSH6 P52701 L1057W 1057 L W 0.934 Pathogenic MSH6 P52701 L1057Y 1057 L Y 0.894 Pathogenic MSH6 P52701 D1058A 1058 D A 0.412 Neutral MSH6 P52701 D1058C 1058 D C 0.652 Pathogenic MSH6 P52701 D1058E 1058 D E 0.57 Pathogenic MSH6 P52701 D1058F 1058 D F 0.86 Pathogenic MSH6 P52701 D1058G 1058 D G 0.482 Neutral MSH6 P52701 D1058H 1058 D H 0.412 Neutral MSH6 P52701 D1058I 1058 D I 0.804 Pathogenic MSH6 P52701 D1058K 1058 D K 0.664 Pathogenic MSH6 P52701 D1058L 1058 D L 0.782 Pathogenic MSH6 P52701 D1058M 1058 D M 0.728 Pathogenic MSH6 P52701 D1058N 1058 D N 0.21 Neutral MSH6 P52701 D1058P 1058 D P 0.762 Pathogenic MSH6 P52701 D1058Q 1058 D Q 0.466 Neutral MSH6 P52701 D1058R 1058 D R 0.61 Pathogenic MSH6 P52701 D1058S 1058 D S 0.514 Pathogenic MSH6 P52701 D1058T 1058 D T 0.514 Pathogenic MSH6 P52701 D1058V 1058 D V 0.838 Pathogenic MSH6 P52701 D1058W 1058 D W 0.92 Pathogenic MSH6 P52701 D1058Y 1058 D Y 0.908 Pathogenic MSH6 P52701 V1059A 1059 V A 0.06 Neutral MSH6 P52701 V1059C 1059 V C 0.106 Neutral MSH6 P52701 V1059D 1059 V D 0.49 Neutral MSH6 P52701 V1059E 1059 V E 0.982 Pathogenic MSH6 P52701 V1059F 1059 V F 0.876 Pathogenic MSH6 P52701 V1059G 1059 V G 0.9 Pathogenic MSH6 P52701 V1059H 1059 V H 0.82 Pathogenic MSH6 P52701 V1059I 1059 V I 0.234 Neutral MSH6 P52701 V1059K 1059 V K 0.99 Pathogenic MSH6 P52701 V1059L 1059 V L 0.336 Neutral MSH6 P52701 V1059M 1059 V M 0.82 Pathogenic MSH6 P52701 V1059N 1059 V N 0.924 Pathogenic MSH6 P52701 V1059P 1059 V P 0.984 Pathogenic MSH6 P52701 V1059Q 1059 V Q 0.988 Pathogenic MSH6 P52701 V1059R 1059 V R 0.956 Pathogenic MSH6 P52701 V1059S 1059 V S 0.724 Pathogenic MSH6 P52701 V1059T 1059 V T 0.746 Pathogenic MSH6 P52701 V1059W 1059 V W 0.904 Pathogenic MSH6 P52701 V1059Y 1059 V Y 0.928 Pathogenic MSH6 P52701 W106A 106 W A 0.128 Neutral MSH6 P52701 W106C 106 W C 0.128 Neutral MSH6 P52701 W106D 106 W D 0.19 Neutral MSH6 P52701 W106E 106 W E 0.24 Neutral MSH6 P52701 W106F 106 W F 0.092 Neutral MSH6 P52701 W106G 106 W G 0.138 Neutral MSH6 P52701 W106H 106 W H 0.128 Neutral MSH6 P52701 W106I 106 W I 0.13 Neutral MSH6 P52701 W106K 106 W K 0.234 Neutral MSH6 P52701 W106L 106 W L 0.094 Neutral MSH6 P52701 W106M 106 W M 0.122 Neutral MSH6 P52701 W106N 106 W N 0.138 Neutral MSH6 P52701 W106P 106 W P 0.146 Neutral MSH6 P52701 W106Q 106 W Q 0.138 Neutral MSH6 P52701 W106R 106 W R 0.228 Neutral MSH6 P52701 W106S 106 W S 0.144 Neutral MSH6 P52701 W106T 106 W T 0.128 Neutral MSH6 P52701 W106V 106 W V 0.15 Neutral MSH6 P52701 W106Y 106 W Y 0.194 Neutral MSH6 P52701 L1060A 1060 L A 0.702 Pathogenic MSH6 P52701 L1060C 1060 L C 0.806 Pathogenic MSH6 P52701 L1060D 1060 L D 0.884 Pathogenic MSH6 P52701 L1060E 1060 L E 0.866 Pathogenic MSH6 P52701 L1060F 1060 L F 0.502 Pathogenic MSH6 P52701 L1060G 1060 L G 0.858 Pathogenic MSH6 P52701 L1060H 1060 L H 0.898 Pathogenic MSH6 P52701 L1060I 1060 L I 0.392 Neutral MSH6 P52701 L1060K 1060 L K 0.69 Pathogenic MSH6 P52701 L1060M 1060 L M 0.562 Pathogenic MSH6 P52701 L1060N 1060 L N 0.796 Pathogenic MSH6 P52701 L1060P 1060 L P 0.69 Pathogenic MSH6 P52701 L1060Q 1060 L Q 0.756 Pathogenic MSH6 P52701 L1060R 1060 L R 0.974 Pathogenic MSH6 P52701 L1060S 1060 L S 0.68 Pathogenic MSH6 P52701 L1060T 1060 L T 0.598 Pathogenic MSH6 P52701 L1060V 1060 L V 0.086 Neutral MSH6 P52701 L1060W 1060 L W 0.846 Pathogenic MSH6 P52701 L1060Y 1060 L Y 0.764 Pathogenic MSH6 P52701 L1061A 1061 L A 0.04 Neutral MSH6 P52701 L1061C 1061 L C 0.026 Neutral MSH6 P52701 L1061D 1061 L D 0.61 Pathogenic MSH6 P52701 L1061E 1061 L E 0.564 Pathogenic MSH6 P52701 L1061F 1061 L F 0.378 Neutral MSH6 P52701 L1061G 1061 L G 0.118 Neutral MSH6 P52701 L1061H 1061 L H 0.162 Neutral MSH6 P52701 L1061I 1061 L I 0.042 Neutral MSH6 P52701 L1061K 1061 L K 0.44 Neutral MSH6 P52701 L1061M 1061 L M 0.016 Neutral MSH6 P52701 L1061N 1061 L N 0.564 Pathogenic MSH6 P52701 L1061P 1061 L P 0.908 Pathogenic MSH6 P52701 L1061Q 1061 L Q 0.056 Neutral MSH6 P52701 L1061R 1061 L R 0.856 Pathogenic MSH6 P52701 L1061S 1061 L S 0.084 Neutral MSH6 P52701 L1061T 1061 L T 0.038 Neutral MSH6 P52701 L1061V 1061 L V 0.004 Neutral MSH6 P52701 L1061W 1061 L W 0.866 Pathogenic MSH6 P52701 L1061Y 1061 L Y 0.876 Pathogenic MSH6 P52701 C1062A 1062 C A 0.094 Neutral MSH6 P52701 C1062D 1062 C D 0.872 Pathogenic MSH6 P52701 C1062E 1062 C E 0.892 Pathogenic MSH6 P52701 C1062F 1062 C F 0.998 Pathogenic MSH6 P52701 C1062G 1062 C G 0.158 Neutral MSH6 P52701 C1062H 1062 C H 0.9 Pathogenic MSH6 P52701 C1062I 1062 C I 0.556 Pathogenic MSH6 P52701 C1062K 1062 C K 0.876 Pathogenic MSH6 P52701 C1062L 1062 C L 0.834 Pathogenic MSH6 P52701 C1062M 1062 C M 0.81 Pathogenic MSH6 P52701 C1062N 1062 C N 0.132 Neutral MSH6 P52701 C1062P 1062 C P 0.976 Pathogenic MSH6 P52701 C1062Q 1062 C Q 0.744 Pathogenic MSH6 P52701 C1062R 1062 C R 0.982 Pathogenic MSH6 P52701 C1062S 1062 C S 0.224 Neutral MSH6 P52701 C1062T 1062 C T 0.798 Pathogenic MSH6 P52701 C1062V 1062 C V 0.956 Pathogenic MSH6 P52701 C1062W 1062 C W 0.996 Pathogenic MSH6 P52701 C1062Y 1062 C Y 0.994 Pathogenic MSH6 P52701 L1063A 1063 L A 0.702 Pathogenic MSH6 P52701 L1063C 1063 L C 0.806 Pathogenic MSH6 P52701 L1063D 1063 L D 0.878 Pathogenic MSH6 P52701 L1063E 1063 L E 0.86 Pathogenic MSH6 P52701 L1063F 1063 L F 0.464 Neutral MSH6 P52701 L1063G 1063 L G 0.848 Pathogenic MSH6 P52701 L1063H 1063 L H 0.898 Pathogenic MSH6 P52701 L1063I 1063 L I 0.38 Neutral MSH6 P52701 L1063K 1063 L K 0.676 Pathogenic MSH6 P52701 L1063M 1063 L M 0.156 Neutral MSH6 P52701 L1063N 1063 L N 0.786 Pathogenic MSH6 P52701 L1063P 1063 L P 0.97 Pathogenic MSH6 P52701 L1063Q 1063 L Q 0.75 Pathogenic MSH6 P52701 L1063R 1063 L R 0.97 Pathogenic 4 MSH6 P52701 L1063S 1063 L S 0.208 Neutral MSH6 P52701 L1063T 1063 L T 0.582 Pathogenic MSH6 P52701 L1063V 1063 L V 0.338 Neutral MSH6 P52701 L1063W 1063 L W 0.848 Pathogenic MSH6 P52701 L1063Y 1063 L Y 0.87 Pathogenic MSH6 P52701 A1064C 1064 A C 0.554 Pathogenic MSH6 P52701 A1064D 1064 A D 0.946 Pathogenic MSH6 P52701 A1064E 1064 A E 0.962 Pathogenic MSH6 P52701 A1064F 1064 A F 0.886 Pathogenic MSH6 P52701 A1064G 1064 A G 0.14 Neutral MSH6 P52701 A1064H 1064 A H 0.93 Pathogenic MSH6 P52701 A1064I 1064 A I 0.958 Pathogenic MSH6 P52701 A1064K 1064 A K 0.964 Pathogenic MSH6 P52701 A1064L 1064 A L 0.814 Pathogenic MSH6 P52701 A1064M 1064 A M 0.812 Pathogenic MSH6 P52701 A1064N 1064 A N 0.864 Pathogenic MSH6 P52701 A1064P 1064 A P 0.958 Pathogenic MSH6 P52701 A1064Q 1064 A Q 0.88 Pathogenic MSH6 P52701 A1064R 1064 A R 0.968 Pathogenic MSH6 P52701 A1064S 1064 A S 0.124 Neutral MSH6 P52701 A1064T 1064 A T 0.192 Neutral MSH6 P52701 A1064V 1064 A V 0.912 Pathogenic MSH6 P52701 A1064W 1064 A W 0.988 Pathogenic MSH6 P52701 A1064Y 1064 A Y 0.826 Pathogenic MSH6 P52701 N1065A 1065 N A 0.29 Neutral MSH6 P52701 N1065C 1065 N C 0.552 Pathogenic MSH6 P52701 N1065D 1065 N D 0.056 Neutral MSH6 P52701 N1065E 1065 N E 0.044 Neutral MSH6 P52701 N1065F 1065 N F 0.43 Neutral MSH6 P52701 N1065G 1065 N G 0.538 Pathogenic MSH6 P52701 N1065H 1065 N H 0.062 Neutral MSH6 P52701 N1065I 1065 N I 0.302 Neutral MSH6 P52701 N1065K 1065 N K 0.07 Neutral MSH6 P52701 N1065L 1065 N L 0.132 Neutral MSH6 P52701 N1065M 1065 N M 0.672 Pathogenic MSH6 P52701 N1065P 1065 N P 0.634 Pathogenic MSH6 P52701 N1065Q 1065 N Q 0.048 Neutral MSH6 P52701 N1065R 1065 N R 0.36 Neutral MSH6 P52701 N1065S 1065 N S 0.054 Neutral MSH6 P52701 N1065T 1065 N T 0.118 Neutral MSH6 P52701 N1065V 1065 N V 0.092 Neutral MSH6 P52701 N1065W 1065 N W 0.882 Pathogenic MSH6 P52701 N1065Y 1065 N Y 0.848 Pathogenic MSH6 P52701 Y1066A 1066 Y A 0.122 Neutral MSH6 P52701 Y1066C 1066 Y C 0.238 Neutral MSH6 P52701 Y1066D 1066 Y D 0.564 Pathogenic MSH6 P52701 Y1066E 1066 Y E 0.55 Pathogenic MSH6 P52701 Y1066F 1066 Y F 0.038 Neutral MSH6 P52701 Y1066G 1066 Y G 0.242 Neutral MSH6 P52701 Y1066H 1066 Y H 0.098 Neutral MSH6 P52701 Y1066I 1066 Y I 0.234 Neutral MSH6 P52701 Y1066K 1066 Y K 0.548 Pathogenic MSH6 P52701 Y1066L 1066 Y L 0.056 Neutral MSH6 P52701 Y1066M 1066 Y M 0.342 Neutral MSH6 P52701 Y1066N 1066 Y N 0.404 Neutral MSH6 P52701 Y1066P 1066 Y P 0.414 Neutral MSH6 P52701 Y1066Q 1066 Y Q 0.204 Neutral MSH6 P52701 Y1066R 1066 Y R 0.594 Pathogenic MSH6 P52701 Y1066S 1066 Y S 0.174 Neutral MSH6 P52701 Y1066T 1066 Y T 0.264 Neutral MSH6 P52701 Y1066V 1066 Y V 0.042 Neutral MSH6 P52701 Y1066W 1066 Y W 0.552 Pathogenic MSH6 P52701 S1067A 1067 S A 0.138 Neutral MSH6 P52701 S1067C 1067 S C 0.254 Neutral MSH6 P52701 S1067D 1067 S D 0.804 Pathogenic MSH6 P52701 S1067E 1067 S E 0.91 Pathogenic MSH6 P52701 S1067F 1067 S F 0.976 Pathogenic MSH6 P52701 S1067G 1067 S G 0.078 Neutral MSH6 P52701 S1067H 1067 S H 0.924 Pathogenic MSH6 P52701 S1067I 1067 S I 0.856 Pathogenic MSH6 P52701 S1067K 1067 S K 0.898 Pathogenic MSH6 P52701 S1067L 1067 S L 0.882 Pathogenic MSH6 P52701 S1067M 1067 S M 0.998 Pathogenic MSH6 P52701 S1067N 1067 S N 0.294 Neutral MSH6 P52701 S1067P 1067 S P 0.918 Pathogenic MSH6 P52701 S1067Q 1067 S Q 0.87 Pathogenic MSH6 P52701 S1067R 1067 S R 0.618 Pathogenic MSH6 P52701 S1067T 1067 S T 0.51 Pathogenic MSH6 P52701 S1067V 1067 S V 0.422 Neutral MSH6 P52701 S1067W 1067 S W 0.984 Pathogenic MSH6 P52701 S1067Y 1067 S Y 0.836 Pathogenic MSH6 P52701 R1068A 1068 R A 0.05 Neutral MSH6 P52701 R1068C 1068 R C 0.134 Neutral MSH6 P52701 R1068D 1068 R D 0.022 Neutral MSH6 P52701 R1068E 1068 R E 0.05 Neutral MSH6 P52701 R1068F 1068 R F 0.24 Neutral MSH6 P52701 R1068G 1068 R G 0.004 Neutral MSH6 P52701 R1068H 1068 R H 0.036 Neutral MSH6 P52701 R1068I 1068 R I 0.178 Neutral MSH6 P52701 R1068K 1068 R K 0.012 Neutral MSH6 P52701 R1068L 1068 R L 0.044 Neutral MSH6 P52701 R1068M 1068 R M 0.06 Neutral MSH6 P52701 R1068N 1068 R N 0.012 Neutral MSH6 P52701 R1068P 1068 R P 0.434 Neutral MSH6 P52701 R1068Q 1068 R Q 0.012 Neutral MSH6 P52701 R1068S 1068 R S 0.02 Neutral MSH6 P52701 R1068T 1068 R T 0.03 Neutral MSH6 P52701 R1068V 1068 R V 0.402 Neutral MSH6 P52701 R1068W 1068 R W 0.624 Pathogenic MSH6 P52701 R1068Y 1068 R Y 0.468 Neutral MSH6 P52701 G1069A 1069 G A 0.042 Neutral MSH6 P52701 G1069C 1069 G C 0.402 Neutral MSH6 P52701 G1069D 1069 G D 0.34 Neutral MSH6 P52701 G1069E 1069 G E 0.596 Pathogenic MSH6 P52701 G1069F 1069 G F 0.598 Pathogenic MSH6 P52701 G1069H 1069 G H 0.566 Pathogenic MSH6 P52701 G1069I 1069 G I 0.878 Pathogenic MSH6 P52701 G1069K 1069 G K 0.914 Pathogenic MSH6 P52701 G1069L 1069 G L 0.886 Pathogenic MSH6 P52701 G1069M 1069 G M 0.864 Pathogenic MSH6 P52701 G1069N 1069 G N 0.384 Neutral MSH6 P52701 G1069P 1069 G P 0.844 Pathogenic MSH6 P52701 G1069Q 1069 G Q 0.442 Neutral MSH6 P52701 G1069R 1069 G R 0.922 Pathogenic MSH6 P52701 G1069S 1069 G S 0.076 Neutral MSH6 P52701 G1069T 1069 G T 0.508 Pathogenic MSH6 P52701 G1069V 1069 G V 0.698 Pathogenic MSH6 P52701 G1069W 1069 G W 0.914 Pathogenic MSH6 P52701 G1069Y 1069 G Y 0.616 Pathogenic MSH6 P52701 P107A 107 P A 0.244 Neutral MSH6 P52701 P107C 107 P C 0.226 Neutral MSH6 P52701 P107D 107 P D 0.126 Neutral MSH6 P52701 P107E 107 P E 0.354 Neutral MSH6 P52701 P107F 107 P F 0.508 Pathogenic MSH6 P52701 P107G 107 P G 0.132 Neutral MSH6 P52701 P107H 107 P H 0.47 Neutral MSH6 P52701 P107I 107 P I 0.204 Neutral MSH6 P52701 P107K 107 P K 0.348 Neutral MSH6 P52701 P107L 107 P L 0.162 Neutral MSH6 P52701 P107M 107 P M 0.372 Neutral MSH6 P52701 P107N 107 P N 0.1 Neutral MSH6 P52701 P107Q 107 P Q 0.36 Neutral MSH6 P52701 P107R 107 P R 0.524 Pathogenic MSH6 P52701 P107S 107 P S 0.16 Neutral MSH6 P52701 P107T 107 P T 0.178 Neutral MSH6 P52701 P107V 107 P V 0.206 Neutral MSH6 P52701 P107W 107 P W 0.602 Pathogenic MSH6 P52701 P107Y 107 P Y 0.532 Pathogenic MSH6 P52701 G1070A 1070 G A 0.032 Neutral MSH6 P52701 G1070C 1070 G C 0.424 Neutral MSH6 P52701 G1070D 1070 G D 0.378 Neutral MSH6 P52701 G1070E 1070 G E 0.606 Pathogenic MSH6 P52701 G1070F 1070 G F 0.596 Pathogenic MSH6 P52701 G1070H 1070 G H 0.912 Pathogenic MSH6 P52701 G1070I 1070 G I 0.632 Pathogenic MSH6 P52701 G1070K 1070 G K 0.912 Pathogenic MSH6 P52701 G1070L 1070 G L 0.554 Pathogenic MSH6 P52701 G1070M 1070 G M 0.536 Pathogenic MSH6 P52701 G1070N 1070 G N 0.664 Pathogenic MSH6 P52701 G1070P 1070 G P 0.842 Pathogenic MSH6 P52701 G1070Q 1070 G Q 0.722 Pathogenic MSH6 P52701 G1070R 1070 G R 0.922 Pathogenic MSH6 P52701 G1070S 1070 G S 0.056 Neutral MSH6 P52701 G1070T 1070 G T 0.79 Pathogenic MSH6 P52701 G1070V 1070 G V 0.708 Pathogenic MSH6 P52701 G1070W 1070 G W 0.914 Pathogenic MSH6 P52701 G1070Y 1070 G Y 0.628 Pathogenic MSH6 P52701 D1071A 1071 D A 0.044 Neutral MSH6 P52701 D1071C 1071 D C 0.262 Neutral MSH6 P52701 D1071E 1071 D E 0.016 Neutral MSH6 P52701 D1071F 1071 D F 0.626 Pathogenic MSH6 P52701 D1071G 1071 D G 0.02 Neutral MSH6 P52701 D1071H 1071 D H 0.16 Neutral MSH6 P52701 D1071I 1071 D I 0.438 Neutral MSH6 P52701 D1071K 1071 D K 0.026 Neutral MSH6 P52701 D1071L 1071 D L 0.43 Neutral MSH6 P52701 D1071M 1071 D M 0.338 Neutral MSH6 P52701 D1071N 1071 D N 0.02 Neutral MSH6 P52701 D1071P 1071 D P 0.466 Neutral MSH6 P52701 D1071Q 1071 D Q 0.092 Neutral MSH6 P52701 D1071R 1071 D R 0.342 Neutral MSH6 P52701 D1071S 1071 D S 0.264 Neutral MSH6 P52701 D1071T 1071 D T 0.196 Neutral MSH6 P52701 D1071V 1071 D V 0.402 Neutral MSH6 P52701 D1071W 1071 D W 0.712 Pathogenic MSH6 P52701 D1071Y 1071 D Y 0.684 Pathogenic MSH6 P52701 G1072A 1072 G A 0.042 Neutral MSH6 P52701 G1072C 1072 G C 0.638 Pathogenic MSH6 P52701 G1072D 1072 G D 0.364 Neutral MSH6 P52701 G1072E 1072 G E 0.458 Neutral MSH6 P52701 G1072F 1072 G F 0.592 Pathogenic MSH6 P52701 G1072H 1072 G H 0.554 Pathogenic MSH6 P52701 G1072I 1072 G I 0.746 Pathogenic MSH6 P52701 G1072K 1072 G K 0.912 Pathogenic MSH6 P52701 G1072L 1072 G L 0.55 Pathogenic MSH6 P52701 G1072M 1072 G M 0.528 Pathogenic MSH6 P52701 G1072N 1072 G N 0.576 Pathogenic MSH6 P52701 G1072P 1072 G P 0.842 Pathogenic MSH6 P52701 G1072Q 1072 G Q 0.454 Neutral MSH6 P52701 G1072R 1072 G R 0.866 Pathogenic MSH6 P52701 G1072S 1072 G S 0.076 Neutral MSH6 P52701 G1072T 1072 G T 0.548 Pathogenic MSH6 P52701 G1072V 1072 G V 0.708 Pathogenic MSH6 P52701 G1072W 1072 G W 0.914 Pathogenic MSH6 P52701 G1072Y 1072 G Y 0.628 Pathogenic MSH6 P52701 P1073A 1073 P A 0.074 Neutral MSH6 P52701 P1073C 1073 P C 0.124 Neutral MSH6 P52701 P1073D 1073 P D 0.04 Neutral MSH6 P52701 P1073E 1073 P E 0.138 Neutral MSH6 P52701 P1073F 1073 P F 0.974 Pathogenic MSH6 P52701 P1073G 1073 P G 0.17 Neutral MSH6 P52701 P1073H 1073 P H 0.85 Pathogenic MSH6 P52701 P1073I 1073 P I 0.224 Neutral MSH6 P52701 P1073K 1073 P K 0.278 Neutral MSH6 P52701 P1073L 1073 P L 0.626 Pathogenic MSH6 P52701 P1073M 1073 P M 0.37 Neutral MSH6 P52701 P1073N 1073 P N 0.034 Neutral MSH6 P52701 P1073Q 1073 P Q 0.182 Neutral MSH6 P52701 P1073R 1073 P R 0.752 Pathogenic MSH6 P52701 P1073S 1073 P S 0.038 Neutral MSH6 P52701 P1073T 1073 P T 0.094 Neutral MSH6 P52701 P1073V 1073 P V 0.07 Neutral MSH6 P52701 P1073W 1073 P W 0.924 Pathogenic MSH6 P52701 P1073Y 1073 P Y 0.882 Pathogenic MSH6 P52701 M1074A 1074 M A 0.154 Neutral MSH6 P52701 M1074C 1074 M C 0.048 Neutral MSH6 P52701 M1074D 1074 M D 0.566 Pathogenic MSH6 P52701 M1074E 1074 M E 0.33 Neutral MSH6 P52701 M1074F 1074 M F 0.11 Neutral MSH6 P52701 M1074G 1074 M G 0.302 Neutral MSH6 P52701 M1074H 1074 M H 0.366 Neutral MSH6 P52701 M1074I 1074 M I 0.1 Neutral MSH6 P52701 M1074K 1074 M K 0.506 Pathogenic MSH6 P52701 M1074L 1074 M L 0.106 Neutral MSH6 P52701 M1074N 1074 M N 0.586 Pathogenic MSH6 P52701 M1074P 1074 M P 0.516 Pathogenic MSH6 P52701 M1074Q 1074 M Q 0.262 Neutral MSH6 P52701 M1074R 1074 M R 0.11 Neutral MSH6 P52701 M1074S 1074 M S 0.04 Neutral MSH6 P52701 M1074T 1074 M T 0.036 Neutral MSH6 P52701 M1074V 1074 M V 0.09 Neutral MSH6 P52701 M1074W 1074 M W 0.928 Pathogenic MSH6 P52701 M1074Y 1074 M Y 0.208 Neutral MSH6 P52701 C1075A 1075 C A 0.174 Neutral MSH6 P52701 C1075D 1075 C D 0.95 Pathogenic MSH6 P52701 C1075E 1075 C E 0.886 Pathogenic MSH6 P52701 C1075F 1075 C F 0.992 Pathogenic MSH6 P52701 C1075G 1075 C G 0.932 Pathogenic MSH6 P52701 C1075H 1075 C H 0.868 Pathogenic MSH6 P52701 C1075I 1075 C I 0.794 Pathogenic MSH6 P52701 C1075K 1075 C K 0.892 Pathogenic MSH6 P52701 C1075L 1075 C L 0.986 Pathogenic MSH6 P52701 C1075M 1075 C M 0.788 Pathogenic MSH6 P52701 C1075N 1075 C N 0.812 Pathogenic MSH6 P52701 C1075P 1075 C P 0.974 Pathogenic MSH6 P52701 C1075Q 1075 C Q 0.692 Pathogenic MSH6 P52701 C1075R 1075 C R 0.998 Pathogenic MSH6 P52701 C1075S 1075 C S 0.086 Neutral MSH6 P52701 C1075T 1075 C T 0.094 Neutral MSH6 P52701 C1075V 1075 C V 0.322 Neutral MSH6 P52701 C1075W 1075 C W 0.992 Pathogenic MSH6 P52701 C1075Y 1075 C Y 0.988 Pathogenic MSH6 P52701 R1076A 1076 R A 0.516 Pathogenic MSH6 P52701 R1076C 1076 R C 0.2 Neutral MSH6 P52701 R1076D 1076 R D 0.852 Pathogenic MSH6 P52701 R1076E 1076 R E 0.364 Neutral MSH6 P52701 R1076F 1076 R F 0.486 Neutral MSH6 P52701 R1076G 1076 R G 0.4 Neutral MSH6 P52701 R1076H 1076 R H 0.568 Pathogenic MSH6 P52701 R1076I 1076 R I 0.394 Neutral MSH6 P52701 R1076K 1076 R K 0.354 Neutral MSH6 P52701 R1076L 1076 R L 0.344 Neutral MSH6 P52701 R1076M 1076 R M 0.228 Neutral MSH6 P52701 R1076N 1076 R N 0.746 Pathogenic MSH6 P52701 R1076P 1076 R P 0.98 Pathogenic MSH6 P52701 R1076Q 1076 R Q 0.176 Neutral MSH6 P52701 R1076S 1076 R S 0.84 Pathogenic MSH6 P52701 R1076T 1076 R T 0.188 Neutral MSH6 P52701 R1076V 1076 R V 0.334 Neutral MSH6 P52701 R1076W 1076 R W 0.968 Pathogenic MSH6 P52701 R1076Y 1076 R Y 0.968 Pathogenic MSH6 P52701 P1077A 1077 P A 0.608 Pathogenic MSH6 P52701 P1077C 1077 P C 0.92 Pathogenic MSH6 P52701 P1077D 1077 P D 0.87 Pathogenic MSH6 P52701 P1077E 1077 P E 0.72 Pathogenic MSH6 P52701 P1077F 1077 P F 1 Pathogenic MSH6 P52701 P1077G 1077 P G 0.696 Pathogenic MSH6 P52701 P1077H 1077 P H 0.98 Pathogenic MSH6 P52701 P1077I 1077 P I 0.934 Pathogenic MSH6 P52701 P1077K 1077 P K 0.952 Pathogenic MSH6 P52701 P1077L 1077 P L 0.998 Pathogenic MSH6 P52701 P1077M 1077 P M 0.962 Pathogenic MSH6 P52701 P1077N 1077 P N 0.79 Pathogenic MSH6 P52701 P1077Q 1077 P Q 0.884 Pathogenic MSH6 P52701 P1077R 1077 P R 0.662 Pathogenic MSH6 P52701 P1077S 1077 P S 0.342 Neutral MSH6 P52701 P1077T 1077 P T 0.746 Pathogenic MSH6 P52701 P1077V 1077 P V 0.85 Pathogenic MSH6 P52701 P1077W 1077 P W 0.936 Pathogenic MSH6 P52701 P1077Y 1077 P Y 0.93 Pathogenic MSH6 P52701 V1078A 1078 V A 0.078 Neutral MSH6 P52701 V1078C 1078 V C 0.312 Neutral MSH6 P52701 V1078D 1078 V D 0.066 Neutral MSH6 P52701 V1078E 1078 V E 0.11 Neutral MSH6 P52701 V1078F 1078 V F 0.686 Pathogenic MSH6 P52701 V1078G 1078 V G 0.568 Pathogenic MSH6 P52701 V1078H 1078 V H 0.336 Neutral MSH6 P52701 V1078I 1078 V I 0.076 Neutral MSH6 P52701 V1078K 1078 V K 0.156 Neutral MSH6 P52701 V1078L 1078 V L 0.068 Neutral MSH6 P52701 V1078M 1078 V M 0.382 Neutral MSH6 P52701 V1078N 1078 V N 0.098 Neutral MSH6 P52701 V1078P 1078 V P 0.454 Neutral MSH6 P52701 V1078Q 1078 V Q 0.112 Neutral MSH6 P52701 V1078R 1078 V R 0.516 Pathogenic MSH6 P52701 V1078S 1078 V S 0.068 Neutral MSH6 P52701 V1078T 1078 V T 0.036 Neutral MSH6 P52701 V1078W 1078 V W 0.782 Pathogenic MSH6 P52701 V1078Y 1078 V Y 0.762 Pathogenic MSH6 P52701 I1079A 1079 I A 0.214 Neutral MSH6 P52701 I1079C 1079 I C 0.384 Neutral MSH6 P52701 I1079D 1079 I D 0.57 Pathogenic MSH6 P52701 I1079E 1079 I E 0.53 Pathogenic MSH6 P52701 I1079F 1079 I F 0.166 Neutral MSH6 P52701 I1079G 1079 I G 0.558 Pathogenic MSH6 P52701 I1079H 1079 I H 0.298 Neutral MSH6 P52701 I1079K 1079 I K 0.564 Pathogenic MSH6 P52701 I1079L 1079 I L 0.018 Neutral MSH6 P52701 I1079M 1079 I M 0.438 Neutral MSH6 P52701 I1079N 1079 I N 0.614 Pathogenic MSH6 P52701 I1079P 1079 I P 0.7 Pathogenic MSH6 P52701 I1079Q 1079 I Q 0.59 Pathogenic MSH6 P52701 I1079R 1079 I R 0.824 Pathogenic MSH6 P52701 I1079S 1079 I S 0.424 Neutral MSH6 P52701 I1079T 1079 I T 0.338 Neutral MSH6 P52701 I1079V 1079 I V 0.014 Neutral MSH6 P52701 I1079W 1079 I W 0.898 Pathogenic MSH6 P52701 I1079Y 1079 I Y 0.904 Pathogenic MSH6 P52701 C108A 108 C A 0.008 Neutral MSH6 P52701 C108D 108 C D 0.11 Neutral MSH6 P52701 C108E 108 C E 0.204 Neutral MSH6 P52701 C108F 108 C F 0.63 Pathogenic MSH6 P52701 C108G 108 C G 0.222 Neutral MSH6 P52701 C108H 108 C H 0.346 Neutral MSH6 P52701 C108I 108 C I 0.408 Neutral MSH6 P52701 C108K 108 C K 0.304 Neutral MSH6 P52701 C108L 108 C L 0.378 Neutral MSH6 P52701 C108M 108 C M 0.24 Neutral MSH6 P52701 C108N 108 C N 0.07 Neutral MSH6 P52701 C108P 108 C P 0.408 Neutral MSH6 P52701 C108Q 108 C Q 0.21 Neutral MSH6 P52701 C108R 108 C R 0.45 Neutral MSH6 P52701 C108S 108 C S 0.016 Neutral MSH6 P52701 C108T 108 C T 0.166 Neutral MSH6 P52701 C108V 108 C V 0.314 Neutral MSH6 P52701 C108W 108 C W 0.702 Pathogenic MSH6 P52701 C108Y 108 C Y 0.67 Pathogenic MSH6 P52701 L1080A 1080 L A 0.062 Neutral MSH6 P52701 L1080C 1080 L C 0.214 Neutral MSH6 P52701 L1080D 1080 L D 0.112 Neutral MSH6 P52701 L1080E 1080 L E 0.09 Neutral MSH6 P52701 L1080F 1080 L F 0.26 Neutral MSH6 P52701 L1080G 1080 L G 0.522 Pathogenic MSH6 P52701 L1080H 1080 L H 0.034 Neutral MSH6 P52701 L1080I 1080 L I 0.066 Neutral MSH6 P52701 L1080K 1080 L K 0.418 Neutral MSH6 P52701 L1080M 1080 L M 0.07 Neutral MSH6 P52701 L1080N 1080 L N 0.308 Neutral MSH6 P52701 L1080P 1080 L P 0.832 Pathogenic MSH6 P52701 L1080Q 1080 L Q 0.282 Neutral MSH6 P52701 L1080R 1080 L R 0.616 Pathogenic MSH6 P52701 L1080S 1080 L S 0.398 Neutral MSH6 P52701 L1080T 1080 L T 0.266 Neutral MSH6 P52701 L1080V 1080 L V 0.046 Neutral MSH6 P52701 L1080W 1080 L W 0.824 Pathogenic MSH6 P52701 L1080Y 1080 L Y 0.628 Pathogenic MSH6 P52701 L1081A 1081 L A 0.008 Neutral MSH6 P52701 L1081C 1081 L C 0.056 Neutral MSH6 P52701 L1081D 1081 L D 0.042 Neutral MSH6 P52701 L1081E 1081 L E 0.044 Neutral MSH6 P52701 L1081F 1081 L F 0.134 Neutral MSH6 P52701 L1081G 1081 L G 0.188 Neutral MSH6 P52701 L1081H 1081 L H 0.044 Neutral MSH6 P52701 L1081I 1081 L I 0.002 Neutral MSH6 P52701 L1081K 1081 L K 0.022 Neutral MSH6 P52701 L1081M 1081 L M 0.012 Neutral MSH6 P52701 L1081N 1081 L N 0.078 Neutral MSH6 P52701 L1081P 1081 L P 0.096 Neutral MSH6 P52701 L1081Q 1081 L Q 0.018 Neutral MSH6 P52701 L1081R 1081 L R 0.278 Neutral MSH6 P52701 L1081S 1081 L S 0.01 Neutral MSH6 P52701 L1081T 1081 L T 0.012 Neutral MSH6 P52701 L1081V 1081 L V 0 Neutral MSH6 P52701 L1081W 1081 L W 0.404 Neutral MSH6 P52701 L1081Y 1081 L Y 0.306 Neutral MSH6 P52701 P1082A 1082 P A 0.134 Neutral MSH6 P52701 P1082C 1082 P C 0.242 Neutral MSH6 P52701 P1082D 1082 P D 0.014 Neutral MSH6 P52701 P1082E 1082 P E 0.082 Neutral MSH6 P52701 P1082F 1082 P F 0.522 Pathogenic MSH6 P52701 P1082G 1082 P G 0.016 Neutral MSH6 P52701 P1082H 1082 P H 0.446 Neutral MSH6 P52701 P1082I 1082 P I 0.218 Neutral MSH6 P52701 P1082K 1082 P K 0.302 Neutral MSH6 P52701 P1082L 1082 P L 0.05 Neutral MSH6 P52701 P1082M 1082 P M 0.386 Neutral MSH6 P52701 P1082N 1082 P N 0.078 Neutral MSH6 P52701 P1082Q 1082 P Q 0.372 Neutral MSH6 P52701 P1082R 1082 P R 0.432 Neutral MSH6 P52701 P1082S 1082 P S 0.008 Neutral MSH6 P52701 P1082T 1082 P T 0.192 Neutral MSH6 P52701 P1082V 1082 P V 0.152 Neutral MSH6 P52701 P1082W 1082 P W 0.616 Pathogenic MSH6 P52701 P1082Y 1082 P Y 0.34 Neutral MSH6 P52701 E1083A 1083 E A 0.066 Neutral MSH6 P52701 E1083C 1083 E C 0.026 Neutral MSH6 P52701 E1083D 1083 E D 0 Neutral MSH6 P52701 E1083F 1083 E F 0.312 Neutral MSH6 P52701 E1083G 1083 E G 0.004 Neutral MSH6 P52701 E1083H 1083 E H 0.162 Neutral MSH6 P52701 E1083I 1083 E I 0.254 Neutral MSH6 P52701 E1083K 1083 E K 0.068 Neutral MSH6 P52701 E1083L 1083 E L 0.044 Neutral MSH6 P52701 E1083M 1083 E M 0.164 Neutral MSH6 P52701 E1083N 1083 E N 0.002 Neutral MSH6 P52701 E1083P 1083 E P 0.282 Neutral MSH6 P52701 E1083Q 1083 E Q 0 Neutral MSH6 P52701 E1083R 1083 E R 0.036 Neutral MSH6 P52701 E1083S 1083 E S 0.014 Neutral MSH6 P52701 E1083T 1083 E T 0.006 Neutral MSH6 P52701 E1083V 1083 E V 0.25 Neutral MSH6 P52701 E1083W 1083 E W 0.43 Neutral MSH6 P52701 E1083Y 1083 E Y 0.194 Neutral MSH6 P52701 D1084A 1084 D A 0.014 Neutral MSH6 P52701 D1084C 1084 D C 0.148 Neutral MSH6 P52701 D1084E 1084 D E 0.038 Neutral MSH6 P52701 D1084F 1084 D F 0.37 Neutral MSH6 P52701 D1084G 1084 D G 0.018 Neutral MSH6 P52701 D1084H 1084 D H 0.106 Neutral MSH6 P52701 D1084I 1084 D I 0.214 Neutral MSH6 P52701 D1084K 1084 D K 0.052 Neutral MSH6 P52701 D1084L 1084 D L 0.262 Neutral MSH6 P52701 D1084M 1084 D M 0.19 Neutral MSH6 P52701 D1084N 1084 D N 0 Neutral MSH6 P52701 D1084P 1084 D P 0.288 Neutral MSH6 P52701 D1084Q 1084 D Q 0.078 Neutral MSH6 P52701 D1084R 1084 D R 0.166 Neutral MSH6 P52701 D1084S 1084 D S 0.002 Neutral MSH6 P52701 D1084T 1084 D T 0.1 Neutral MSH6 P52701 D1084V 1084 D V 0.242 Neutral MSH6 P52701 D1084W 1084 D W 0.434 Neutral MSH6 P52701 D1084Y 1084 D Y 0.432 Neutral MSH6 P52701 T1085A 1085 T A 0 Neutral MSH6 P52701 T1085C 1085 T C 0.064 Neutral MSH6 P52701 T1085D 1085 T D 0.022 Neutral MSH6 P52701 T1085E 1085 T E 0.024 Neutral MSH6 P52701 T1085F 1085 T F 0.214 Neutral MSH6 P52701 T1085G 1085 T G 0.002 Neutral MSH6 P52701 T1085H 1085 T H 0.064 Neutral MSH6 P52701 T1085I 1085 T I 0.066 Neutral MSH6 P52701 T1085K 1085 T K 0.002 Neutral MSH6 P52701 T1085L 1085 T L 0.074 Neutral MSH6 P52701 T1085M 1085 T M 0.044 Neutral MSH6 P52701 T1085N 1085 T N 0.002 Neutral MSH6 P52701 T1085P 1085 T P 0.056 Neutral MSH6 P52701 T1085Q 1085 T Q 0 Neutral MSH6 P52701 T1085R 1085 T R 0.142 Neutral MSH6 P52701 T1085S 1085 T S 0 Neutral MSH6 P52701 T1085V 1085 T V 0.212 Neutral MSH6 P52701 T1085W 1085 T W 0.466 Neutral MSH6 P52701 T1085Y 1085 T Y 0.424 Neutral MSH6 P52701 P1086A 1086 P A 0.034 Neutral MSH6 P52701 P1086C 1086 P C 0.136 Neutral MSH6 P52701 P1086D 1086 P D 0.086 Neutral MSH6 P52701 P1086E 1086 P E 0.068 Neutral MSH6 P52701 P1086F 1086 P F 0.312 Neutral MSH6 P52701 P1086G 1086 P G 0.01 Neutral MSH6 P52701 P1086H 1086 P H 0.288 Neutral MSH6 P52701 P1086I 1086 P I 0.05 Neutral MSH6 P52701 P1086K 1086 P K 0.066 Neutral MSH6 P52701 P1086L 1086 P L 0.056 Neutral MSH6 P52701 P1086M 1086 P M 0.234 Neutral MSH6 P52701 P1086N 1086 P N 0.068 Neutral MSH6 P52701 P1086Q 1086 P Q 0.07 Neutral MSH6 P52701 P1086R 1086 P R 0.266 Neutral MSH6 P52701 P1086S 1086 P S 0.002 Neutral MSH6 P52701 P1086T 1086 P T 0.086 Neutral MSH6 P52701 P1086V 1086 P V 0.044 Neutral MSH6 P52701 P1086W 1086 P W 0.462 Neutral MSH6 P52701 P1086Y 1086 P Y 0.39 Neutral MSH6 P52701 P1087A 1087 P A 0.074 Neutral MSH6 P52701 P1087C 1087 P C 0.552 Pathogenic MSH6 P52701 P1087D 1087 P D 0.04 Neutral MSH6 P52701 P1087E 1087 P E 0.14 Neutral MSH6 P52701 P1087F 1087 P F 0.866 Pathogenic MSH6 P52701 P1087G 1087 P G 0.278 Neutral MSH6 P52701 P1087H 1087 P H 0.516 Pathogenic MSH6 P52701 P1087I 1087 P I 0.118 Neutral MSH6 P52701 P1087K 1087 P K 0.622 Pathogenic MSH6 P52701 P1087L 1087 P L 0.384 Neutral MSH6 P52701 P1087M 1087 P M 0.668 Pathogenic MSH6 P52701 P1087N 1087 P N 0.232 Neutral MSH6 P52701 P1087Q 1087 P Q 0.182 Neutral MSH6 P52701 P1087R 1087 P R 0.588 Pathogenic MSH6 P52701 P1087S 1087 P S 0.032 Neutral MSH6 P52701 P1087T 1087 P T 0.052 Neutral MSH6 P52701 P1087V 1087 P V 0.086 Neutral MSH6 P52701 P1087W 1087 P W 0.882 Pathogenic MSH6 P52701 P1087Y 1087 P Y 0.582 Pathogenic MSH6 P52701 F1088A 1088 F A 0.148 Neutral MSH6 P52701 F1088C 1088 F C 0.214 Neutral MSH6 P52701 F1088D 1088 F D 0.81 Pathogenic MSH6 P52701 F1088E 1088 F E 0.898 Pathogenic MSH6 P52701 F1088G 1088 F G 0.25 Neutral MSH6 P52701 F1088H 1088 F H 0.598 Pathogenic MSH6 P52701 F1088I 1088 F I 0.112 Neutral MSH6 P52701 F1088K 1088 F K 0.51 Pathogenic MSH6 P52701 F1088L 1088 F L 0.08 Neutral MSH6 P52701 F1088M 1088 F M 0.244 Neutral MSH6 P52701 F1088N 1088 F N 0.74 Pathogenic MSH6 P52701 F1088P 1088 F P 0.846 Pathogenic MSH6 P52701 F1088Q 1088 F Q 0.77 Pathogenic MSH6 P52701 F1088R 1088 F R 0.55 Pathogenic MSH6 P52701 F1088S 1088 F S 0.66 Pathogenic MSH6 P52701 F1088T 1088 F T 0.372 Neutral MSH6 P52701 F1088V 1088 F V 0.166 Neutral MSH6 P52701 F1088W 1088 F W 0.786 Pathogenic MSH6 P52701 F1088Y 1088 F Y 0.202 Neutral MSH6 P52701 L1089A 1089 L A 0.272 Neutral MSH6 P52701 L1089C 1089 L C 0.338 Neutral MSH6 P52701 L1089D 1089 L D 0.146 Neutral MSH6 P52701 L1089E 1089 L E 0.076 Neutral MSH6 P52701 L1089F 1089 L F 0.552 Pathogenic MSH6 P52701 L1089G 1089 L G 0.538 Pathogenic MSH6 P52701 L1089H 1089 L H 0.176 Neutral MSH6 P52701 L1089I 1089 L I 0.048 Neutral MSH6 P52701 L1089K 1089 L K 0.042 Neutral MSH6 P52701 L1089M 1089 L M 0.448 Neutral MSH6 P52701 L1089N 1089 L N 0.526 Pathogenic MSH6 P52701 L1089P 1089 L P 0.898 Pathogenic MSH6 P52701 L1089Q 1089 L Q 0.05 Neutral MSH6 P52701 L1089R 1089 L R 0.554 Pathogenic MSH6 P52701 L1089S 1089 L S 0.39 Neutral MSH6 P52701 L1089T 1089 L T 0.054 Neutral MSH6 P52701 L1089V 1089 L V 0.014 Neutral MSH6 P52701 L1089W 1089 L W 0.868 Pathogenic MSH6 P52701 L1089Y 1089 L Y 0.866 Pathogenic MSH6 P52701 L109A 109 L A 0.128 Neutral MSH6 P52701 L109C 109 L C 0.134 Neutral MSH6 P52701 L109D 109 L D 0.246 Neutral MSH6 P52701 L109E 109 L E 0.23 Neutral MSH6 P52701 L109F 109 L F 0.37 Neutral MSH6 P52701 L109G 109 L G 0.262 Neutral MSH6 P52701 L109H 109 L H 0.126 Neutral MSH6 P52701 L109I 109 L I 0.06 Neutral MSH6 P52701 L109K 109 L K 0.18 Neutral MSH6 P52701 L109M 109 L M 0.014 Neutral MSH6 P52701 L109N 109 L N 0.238 Neutral MSH6 P52701 L109P 109 L P 0.338 Neutral MSH6 P52701 L109Q 109 L Q 0.104 Neutral MSH6 P52701 L109R 109 L R 0.5 Pathogenic MSH6 P52701 L109S 109 L S 0.194 Neutral MSH6 P52701 L109T 109 L T 0.174 Neutral MSH6 P52701 L109V 109 L V 0.022 Neutral MSH6 P52701 L109W 109 L W 0.53 Pathogenic MSH6 P52701 L109Y 109 L Y 0.492 Neutral MSH6 P52701 E1090A 1090 E A 0.242 Neutral MSH6 P52701 E1090C 1090 E C 0.446 Neutral MSH6 P52701 E1090D 1090 E D 0.014 Neutral MSH6 P52701 E1090F 1090 E F 0.848 Pathogenic MSH6 P52701 E1090G 1090 E G 0.028 Neutral MSH6 P52701 E1090H 1090 E H 0.596 Pathogenic MSH6 P52701 E1090I 1090 E I 0.25 Neutral MSH6 P52701 E1090K 1090 E K 0.05 Neutral MSH6 P52701 E1090L 1090 E L 0.81 Pathogenic MSH6 P52701 E1090M 1090 E M 0.69 Pathogenic MSH6 P52701 E1090N 1090 E N 0.012 Neutral MSH6 P52701 E1090P 1090 E P 0.868 Pathogenic MSH6 P52701 E1090Q 1090 E Q 0.014 Neutral MSH6 P52701 E1090R 1090 E R 0.132 Neutral MSH6 P52701 E1090S 1090 E S 0.042 Neutral MSH6 P52701 E1090T 1090 E T 0.294 Neutral MSH6 P52701 E1090V 1090 E V 0.094 Neutral MSH6 P52701 E1090W 1090 E W 0.968 Pathogenic MSH6 P52701 E1090Y 1090 E Y 0.372 Neutral MSH6 P52701 L1091A 1091 L A 0.558 Pathogenic MSH6 P52701 L1091C 1091 L C 0.27 Neutral MSH6 P52701 L1091D 1091 L D 0.894 Pathogenic MSH6 P52701 L1091E 1091 L E 0.876 Pathogenic MSH6 P52701 L1091F 1091 L F 0.546 Pathogenic MSH6 P52701 L1091G 1091 L G 0.796 Pathogenic MSH6 P52701 L1091H 1091 L H 0.796 Pathogenic MSH6 P52701 L1091I 1091 L I 0.124 Neutral MSH6 P52701 L1091K 1091 L K 0.744 Pathogenic MSH6 P52701 L1091M 1091 L M 0.192 Neutral MSH6 P52701 L1091N 1091 L N 0.762 Pathogenic MSH6 P52701 L1091P 1091 L P 0.998 Pathogenic MSH6 P52701 L1091Q 1091 L Q 0.612 Pathogenic MSH6 P52701 L1091R 1091 L R 0.988 Pathogenic MSH6 P52701 L1091S 1091 L S 0.608 Pathogenic MSH6 P52701 L1091T 1091 L T 0.58 Pathogenic MSH6 P52701 L1091V 1091 L V 0.088 Neutral MSH6 P52701 L1091W 1091 L W 0.94 Pathogenic MSH6 P52701 L1091Y 1091 L Y 0.902 Pathogenic MSH6 P52701 K1092A 1092 K A 0.062 Neutral MSH6 P52701 K1092C 1092 K C 0.056 Neutral MSH6 P52701 K1092D 1092 K D 0.002 Neutral MSH6 P52701 K1092E 1092 K E 0.004 Neutral MSH6 P52701 K1092F 1092 K F 0.358 Neutral MSH6 P52701 K1092G 1092 K G 0.044 Neutral MSH6 P52701 K1092H 1092 K H 0.082 Neutral MSH6 P52701 K1092I 1092 K I 0.098 Neutral MSH6 P52701 K1092L 1092 K L 0.38 Neutral MSH6 P52701 K1092M 1092 K M 0.184 Neutral MSH6 P52701 K1092N 1092 K N 0.12 Neutral MSH6 P52701 K1092P 1092 K P 0.392 Neutral MSH6 P52701 K1092Q 1092 K Q 0.01 Neutral MSH6 P52701 K1092R 1092 K R 0.006 Neutral MSH6 P52701 K1092S 1092 K S 0.11 Neutral MSH6 P52701 K1092T 1092 K T 0.014 Neutral MSH6 P52701 K1092V 1092 K V 0.042 Neutral MSH6 P52701 K1092W 1092 K W 0.664 Pathogenic MSH6 P52701 K1092Y 1092 K Y 0.568 Pathogenic MSH6 P52701 G1093A 1093 G A 0.024 Neutral MSH6 P52701 G1093C 1093 G C 0.344 Neutral MSH6 P52701 G1093D 1093 G D 0.224 Neutral MSH6 P52701 G1093E 1093 G E 0.304 Neutral MSH6 P52701 G1093F 1093 G F 0.758 Pathogenic MSH6 P52701 G1093H 1093 G H 0.7 Pathogenic MSH6 P52701 G1093I 1093 G I 0.676 Pathogenic MSH6 P52701 G1093K 1093 G K 0.384 Neutral MSH6 P52701 G1093L 1093 G L 0.674 Pathogenic MSH6 P52701 G1093M 1093 G M 0.69 Pathogenic MSH6 P52701 G1093N 1093 G N 0.26 Neutral MSH6 P52701 G1093P 1093 G P 0.634 Pathogenic MSH6 P52701 G1093Q 1093 G Q 0.28 Neutral MSH6 P52701 G1093R 1093 G R 0.75 Pathogenic MSH6 P52701 G1093S 1093 G S 0.034 Neutral MSH6 P52701 G1093T 1093 G T 0.46 Neutral MSH6 P52701 G1093V 1093 G V 0.666 Pathogenic MSH6 P52701 G1093W 1093 G W 0.758 Pathogenic MSH6 P52701 G1093Y 1093 G Y 0.744 Pathogenic MSH6 P52701 S1094A 1094 S A 0.066 Neutral MSH6 P52701 S1094C 1094 S C 0.39 Neutral MSH6 P52701 S1094D 1094 S D 0.416 Neutral MSH6 P52701 S1094E 1094 S E 0.648 Pathogenic MSH6 P52701 S1094F 1094 S F 0.804 Pathogenic MSH6 P52701 S1094G 1094 S G 0.026 Neutral MSH6 P52701 S1094H 1094 S H 0.732 Pathogenic MSH6 P52701 S1094I 1094 S I 0.51 Pathogenic MSH6 P52701 S1094K 1094 S K 0.666 Pathogenic MSH6 P52701 S1094L 1094 S L 0.148 Neutral MSH6 P52701 S1094M 1094 S M 0.934 Pathogenic MSH6 P52701 S1094N 1094 S N 0.356 Neutral MSH6 P52701 S1094P 1094 S P 0.528 Pathogenic MSH6 P52701 S1094Q 1094 S Q 0.6 Pathogenic MSH6 P52701 S1094R 1094 S R 0.734 Pathogenic MSH6 P52701 S1094T 1094 S T 0.568 Pathogenic MSH6 P52701 S1094V 1094 S V 0.758 Pathogenic MSH6 P52701 S1094W 1094 S W 0.922 Pathogenic MSH6 P52701 S1094Y 1094 S Y 0.896 Pathogenic MSH6 P52701 R1095A 1095 R A 0.426 Neutral MSH6 P52701 R1095C 1095 R C 0.42 Neutral MSH6 P52701 R1095D 1095 R D 0.564 Pathogenic MSH6 P52701 R1095E 1095 R E 0.482 Neutral MSH6 P52701 R1095F 1095 R F 0.758 Pathogenic MSH6 P52701 R1095G 1095 R G 0.182 Neutral MSH6 P52701 R1095H 1095 R H 0.416 Neutral MSH6 P52701 R1095I 1095 R I 0.214 Neutral MSH6 P52701 R1095K 1095 R K 0.098 Neutral MSH6 P52701 R1095L 1095 R L 0.348 Neutral MSH6 P52701 R1095M 1095 R M 0.61 Pathogenic MSH6 P52701 R1095N 1095 R N 0.442 Neutral MSH6 P52701 R1095P 1095 R P 0.642 Pathogenic MSH6 P52701 R1095Q 1095 R Q 0.156 Neutral MSH6 P52701 R1095S 1095 R S 0.41 Neutral MSH6 P52701 R1095T 1095 R T 0.492 Neutral MSH6 P52701 R1095V 1095 R V 0.158 Neutral MSH6 P52701 R1095W 1095 R W 0.838 Pathogenic MSH6 P52701 R1095Y 1095 R Y 0.158 Neutral MSH6 P52701 H1096A 1096 H A 0.716 Pathogenic MSH6 P52701 H1096C 1096 H C 0.696 Pathogenic MSH6 P52701 H1096D 1096 H D 0.642 Pathogenic MSH6 P52701 H1096E 1096 H E 0.818 Pathogenic MSH6 P52701 H1096F 1096 H F 0.808 Pathogenic MSH6 P52701 H1096G 1096 H G 0.512 Pathogenic MSH6 P52701 H1096I 1096 H I 0.898 Pathogenic MSH6 P52701 H1096K 1096 H K 0.68 Pathogenic MSH6 P52701 H1096L 1096 H L 0.744 Pathogenic MSH6 P52701 H1096M 1096 H M 0.646 Pathogenic MSH6 P52701 H1096N 1096 H N 0.636 Pathogenic MSH6 P52701 H1096P 1096 H P 0.986 Pathogenic MSH6 P52701 H1096Q 1096 H Q 0.83 Pathogenic MSH6 P52701 H1096R 1096 H R 0.91 Pathogenic MSH6 P52701 H1096S 1096 H S 0.66 Pathogenic MSH6 P52701 H1096T 1096 H T 0.564 Pathogenic MSH6 P52701 H1096V 1096 H V 0.704 Pathogenic MSH6 P52701 H1096W 1096 H W 0.964 Pathogenic MSH6 P52701 H1096Y 1096 H Y 0.634 Pathogenic MSH6 P52701 P1097A 1097 P A 0.628 Pathogenic MSH6 P52701 P1097C 1097 P C 0.918 Pathogenic MSH6 P52701 P1097D 1097 P D 0.868 Pathogenic MSH6 P52701 P1097E 1097 P E 0.96 Pathogenic MSH6 P52701 P1097F 1097 P F 1 Pathogenic MSH6 P52701 P1097G 1097 P G 0.694 Pathogenic MSH6 P52701 P1097H 1097 P H 0.978 Pathogenic MSH6 P52701 P1097I 1097 P I 0.938 Pathogenic MSH6 P52701 P1097K 1097 P K 0.95 Pathogenic MSH6 P52701 P1097L 1097 P L 0.998 Pathogenic MSH6 P52701 P1097M 1097 P M 0.96 Pathogenic MSH6 P52701 P1097N 1097 P N 0.788 Pathogenic MSH6 P52701 P1097Q 1097 P Q 0.882 Pathogenic MSH6 P52701 P1097R 1097 P R 0.986 Pathogenic MSH6 P52701 P1097S 1097 P S 0.346 Neutral MSH6 P52701 P1097T 1097 P T 0.738 Pathogenic MSH6 P52701 P1097V 1097 P V 0.844 Pathogenic MSH6 P52701 P1097W 1097 P W 0.932 Pathogenic MSH6 P52701 P1097Y 1097 P Y 0.928 Pathogenic MSH6 P52701 C1098A 1098 C A 0.156 Neutral MSH6 P52701 C1098D 1098 C D 0.93 Pathogenic MSH6 P52701 C1098E 1098 C E 0.904 Pathogenic MSH6 P52701 C1098F 1098 C F 0.996 Pathogenic MSH6 P52701 C1098G 1098 C G 0.91 Pathogenic MSH6 P52701 C1098H 1098 C H 0.888 Pathogenic MSH6 P52701 C1098I 1098 C I 0.396 Neutral MSH6 P52701 C1098K 1098 C K 0.898 Pathogenic MSH6 P52701 C1098L 1098 C L 0.842 Pathogenic MSH6 P52701 C1098M 1098 C M 0.688 Pathogenic MSH6 P52701 C1098N 1098 C N 0.756 Pathogenic MSH6 P52701 C1098P 1098 C P 0.976 Pathogenic MSH6 P52701 C1098Q 1098 C Q 0.714 Pathogenic MSH6 P52701 C1098R 1098 C R 0.996 Pathogenic MSH6 P52701 C1098S 1098 C S 0.11 Neutral MSH6 P52701 C1098T 1098 C T 0.13 Neutral MSH6 P52701 C1098V 1098 C V 0.28 Neutral MSH6 P52701 C1098W 1098 C W 0.996 Pathogenic MSH6 P52701 C1098Y 1098 C Y 0.992 Pathogenic MSH6 P52701 I1099A 1099 I A 0.05 Neutral MSH6 P52701 I1099C 1099 I C 0.278 Neutral MSH6 P52701 I1099D 1099 I D 0.634 Pathogenic MSH6 P52701 I1099E 1099 I E 0.618 Pathogenic MSH6 P52701 I1099F 1099 I F 0.704 Pathogenic MSH6 P52701 I1099G 1099 I G 0.494 Neutral MSH6 P52701 I1099H 1099 I H 0.268 Neutral MSH6 P52701 I1099K 1099 I K 0.47 Neutral MSH6 P52701 I1099L 1099 I L 0.008 Neutral MSH6 P52701 I1099M 1099 I M 0.04 Neutral MSH6 P52701 I1099N 1099 I N 0.676 Pathogenic MSH6 P52701 I1099P 1099 I P 0.766 Pathogenic MSH6 P52701 I1099Q 1099 I Q 0.65 Pathogenic MSH6 P52701 I1099R 1099 I R 0.834 Pathogenic MSH6 P52701 I1099S 1099 I S 0.43 Neutral MSH6 P52701 I1099T 1099 I T 0.332 Neutral MSH6 P52701 I1099V 1099 I V 0 Neutral MSH6 P52701 I1099W 1099 I W 0.886 Pathogenic MSH6 P52701 I1099Y 1099 I Y 0.884 Pathogenic MSH6 P52701 F11A 11 F A 0.1 Neutral MSH6 P52701 F11C 11 F C 0.088 Neutral MSH6 P52701 F11D 11 F D 0.164 Neutral MSH6 P52701 F11E 11 F E 0.196 Neutral MSH6 P52701 F11G 11 F G 0.136 Neutral MSH6 P52701 F11H 11 F H 0.072 Neutral MSH6 P52701 F11I 11 F I 0.076 Neutral MSH6 P52701 F11K 11 F K 0.188 Neutral MSH6 P52701 F11L 11 F L 0.002 Neutral MSH6 P52701 F11M 11 F M 0.086 Neutral MSH6 P52701 F11N 11 F N 0.176 Neutral MSH6 P52701 F11P 11 F P 0.184 Neutral MSH6 P52701 F11Q 11 F Q 0.168 Neutral MSH6 P52701 F11R 11 F R 0.146 Neutral MSH6 P52701 F11S 11 F S 0.158 Neutral MSH6 P52701 F11T 11 F T 0.172 Neutral MSH6 P52701 F11V 11 F V 0.166 Neutral MSH6 P52701 F11W 11 F W 0.278 Neutral MSH6 P52701 F11Y 11 F Y 0.102 Neutral MSH6 P52701 V110A 110 V A 0.05 Neutral MSH6 P52701 V110C 110 V C 0.108 Neutral MSH6 P52701 V110D 110 V D 0.202 Neutral MSH6 P52701 V110E 110 V E 0.332 Neutral MSH6 P52701 V110F 110 V F 0.374 Neutral MSH6 P52701 V110G 110 V G 0.286 Neutral MSH6 P52701 V110H 110 V H 0.228 Neutral MSH6 P52701 V110I 110 V I 0.006 Neutral MSH6 P52701 V110K 110 V K 0.302 Neutral MSH6 P52701 V110L 110 V L 0.128 Neutral MSH6 P52701 V110M 110 V M 0.17 Neutral MSH6 P52701 V110N 110 V N 0.222 Neutral MSH6 P52701 V110P 110 V P 0.348 Neutral MSH6 P52701 V110Q 110 V Q 0.358 Neutral MSH6 P52701 V110R 110 V R 0.494 Neutral MSH6 P52701 V110S 110 V S 0.146 Neutral MSH6 P52701 V110T 110 V T 0.128 Neutral MSH6 P52701 V110W 110 V W 0.552 Pathogenic MSH6 P52701 V110Y 110 V Y 0.47 Neutral MSH6 P52701 T1100A 1100 T A 0.01 Neutral MSH6 P52701 T1100C 1100 T C 0.144 Neutral MSH6 P52701 T1100D 1100 T D 0.162 Neutral MSH6 P52701 T1100E 1100 T E 0.06 Neutral MSH6 P52701 T1100F 1100 T F 0.534 Pathogenic MSH6 P52701 T1100G 1100 T G 0.014 Neutral MSH6 P52701 T1100H 1100 T H 0.312 Neutral MSH6 P52701 T1100I 1100 T I 0.056 Neutral MSH6 P52701 T1100K 1100 T K 0.054 Neutral MSH6 P52701 T1100L 1100 T L 0.026 Neutral MSH6 P52701 T1100M 1100 T M 0.07 Neutral MSH6 P52701 T1100N 1100 T N 0.002 Neutral MSH6 P52701 T1100P 1100 T P 0.346 Neutral MSH6 P52701 T1100Q 1100 T Q 0.186 Neutral MSH6 P52701 T1100R 1100 T R 0.324 Neutral MSH6 P52701 T1100S 1100 T S 0.002 Neutral MSH6 P52701 T1100V 1100 T V 0.036 Neutral MSH6 P52701 T1100W 1100 T W 0.838 Pathogenic MSH6 P52701 T1100Y 1100 T Y 0.624 Pathogenic MSH6 P52701 K1101A 1101 K A 0.082 Neutral MSH6 P52701 K1101C 1101 K C 0.188 Neutral MSH6 P52701 K1101D 1101 K D 0.03 Neutral MSH6 P52701 K1101E 1101 K E 0.036 Neutral MSH6 P52701 K1101F 1101 K F 0.66 Pathogenic MSH6 P52701 K1101G 1101 K G 0.414 Neutral MSH6 P52701 K1101H 1101 K H 0.028 Neutral MSH6 P52701 K1101I 1101 K I 0.108 Neutral MSH6 P52701 K1101L 1101 K L 0.624 Pathogenic MSH6 P52701 K1101M 1101 K M 0.296 Neutral MSH6 P52701 K1101N 1101 K N 0.04 Neutral MSH6 P52701 K1101P 1101 K P 0.714 Pathogenic MSH6 P52701 K1101Q 1101 K Q 0.046 Neutral MSH6 P52701 K1101R 1101 K R 0.034 Neutral MSH6 P52701 K1101S 1101 K S 0.062 Neutral MSH6 P52701 K1101T 1101 K T 0.064 Neutral MSH6 P52701 K1101V 1101 K V 0.642 Pathogenic MSH6 P52701 K1101W 1101 K W 0.884 Pathogenic MSH6 P52701 K1101Y 1101 K Y 0.808 Pathogenic MSH6 P52701 T1102A 1102 T A 0.022 Neutral MSH6 P52701 T1102C 1102 T C 0.356 Neutral MSH6 P52701 T1102D 1102 T D 0.372 Neutral MSH6 P52701 T1102E 1102 T E 0.458 Neutral MSH6 P52701 T1102F 1102 T F 0.398 Neutral MSH6 P52701 T1102G 1102 T G 0.242 Neutral MSH6 P52701 T1102H 1102 T H 0.322 Neutral MSH6 P52701 T1102I 1102 T I 0.096 Neutral MSH6 P52701 T1102K 1102 T K 0.364 Neutral MSH6 P52701 T1102L 1102 T L 0.052 Neutral MSH6 P52701 T1102M 1102 T M 0.468 Neutral MSH6 P52701 T1102N 1102 T N 0.144 Neutral MSH6 P52701 T1102P 1102 T P 0.512 Pathogenic MSH6 P52701 T1102Q 1102 T Q 0.15 Neutral MSH6 P52701 T1102R 1102 T R 0.692 Pathogenic MSH6 P52701 T1102S 1102 T S 0.026 Neutral MSH6 P52701 T1102V 1102 T V 0.054 Neutral MSH6 P52701 T1102W 1102 T W 0.886 Pathogenic MSH6 P52701 T1102Y 1102 T Y 0.54 Pathogenic MSH6 P52701 F1103A 1103 F A 0.054 Neutral MSH6 P52701 F1103C 1103 F C 0.128 Neutral MSH6 P52701 F1103D 1103 F D 0.124 Neutral MSH6 P52701 F1103E 1103 F E 0.266 Neutral MSH6 P52701 F1103G 1103 F G 0.056 Neutral MSH6 P52701 F1103H 1103 F H 0.102 Neutral MSH6 P52701 F1103I 1103 F I 0.134 Neutral MSH6 P52701 F1103K 1103 F K 0.252 Neutral MSH6 P52701 F1103L 1103 F L 0.004 Neutral MSH6 P52701 F1103M 1103 F M 0.12 Neutral MSH6 P52701 F1103N 1103 F N 0.248 Neutral MSH6 P52701 F1103P 1103 F P 0.046 Neutral MSH6 P52701 F1103Q 1103 F Q 0.248 Neutral MSH6 P52701 F1103R 1103 F R 0.05 Neutral MSH6 P52701 F1103S 1103 F S 0.02 Neutral MSH6 P52701 F1103T 1103 F T 0.108 Neutral MSH6 P52701 F1103V 1103 F V 0.28 Neutral MSH6 P52701 F1103W 1103 F W 0.452 Neutral MSH6 P52701 F1103Y 1103 F Y 0.116 Neutral MSH6 P52701 F1104A 1104 F A 0.054 Neutral MSH6 P52701 F1104C 1104 F C 0.13 Neutral MSH6 P52701 F1104D 1104 F D 0.124 Neutral MSH6 P52701 F1104E 1104 F E 0.15 Neutral MSH6 P52701 F1104G 1104 F G 0.052 Neutral MSH6 P52701 F1104H 1104 F H 0.108 Neutral MSH6 P52701 F1104I 1104 F I 0.004 Neutral MSH6 P52701 F1104K 1104 F K 0.266 Neutral MSH6 P52701 F1104L 1104 F L 0.006 Neutral MSH6 P52701 F1104M 1104 F M 0.088 Neutral MSH6 P52701 F1104N 1104 F N 0.042 Neutral MSH6 P52701 F1104P 1104 F P 0.278 Neutral MSH6 P52701 F1104Q 1104 F Q 0.244 Neutral MSH6 P52701 F1104R 1104 F R 0.118 Neutral MSH6 P52701 F1104S 1104 F S 0.02 Neutral MSH6 P52701 F1104T 1104 F T 0.02 Neutral MSH6 P52701 F1104V 1104 F V 0.108 Neutral MSH6 P52701 F1104W 1104 F W 0.468 Neutral MSH6 P52701 F1104Y 1104 F Y 0.236 Neutral MSH6 P52701 G1105A 1105 G A 0.01 Neutral MSH6 P52701 G1105C 1105 G C 0.444 Neutral MSH6 P52701 G1105D 1105 G D 0.298 Neutral MSH6 P52701 G1105E 1105 G E 0.394 Neutral MSH6 P52701 G1105F 1105 G F 0.83 Pathogenic MSH6 P52701 G1105H 1105 G H 0.738 Pathogenic MSH6 P52701 G1105I 1105 G I 0.75 Pathogenic MSH6 P52701 G1105K 1105 G K 0.464 Neutral MSH6 P52701 G1105L 1105 G L 0.744 Pathogenic MSH6 P52701 G1105M 1105 G M 0.708 Pathogenic MSH6 P52701 G1105N 1105 G N 0.316 Neutral MSH6 P52701 G1105P 1105 G P 0.77 Pathogenic MSH6 P52701 G1105Q 1105 G Q 0.54 Pathogenic MSH6 P52701 G1105R 1105 G R 0.498 Neutral MSH6 P52701 G1105S 1105 G S 0.036 Neutral MSH6 P52701 G1105T 1105 G T 0.508 Pathogenic MSH6 P52701 G1105V 1105 G V 0.758 Pathogenic MSH6 P52701 G1105W 1105 G W 0.828 Pathogenic MSH6 P52701 G1105Y 1105 G Y 0.818 Pathogenic MSH6 P52701 D1106A 1106 D A 0.126 Neutral MSH6 P52701 D1106C 1106 D C 0.73 Pathogenic MSH6 P52701 D1106E 1106 D E 0.044 Neutral MSH6 P52701 D1106F 1106 D F 0.928 Pathogenic MSH6 P52701 D1106G 1106 D G 0.066 Neutral MSH6 P52701 D1106H 1106 D H 0.548 Pathogenic MSH6 P52701 D1106I 1106 D I 0.886 Pathogenic MSH6 P52701 D1106K 1106 D K 0.74 Pathogenic MSH6 P52701 D1106L 1106 D L 0.884 Pathogenic MSH6 P52701 D1106M 1106 D M 0.796 Pathogenic MSH6 P52701 D1106N 1106 D N 0.028 Neutral MSH6 P52701 D1106P 1106 D P 0.804 Pathogenic MSH6 P52701 D1106Q 1106 D Q 0.468 Neutral MSH6 P52701 D1106R 1106 D R 0.74 Pathogenic MSH6 P52701 D1106S 1106 D S 0.028 Neutral MSH6 P52701 D1106T 1106 D T 0.054 Neutral MSH6 P52701 D1106V 1106 D V 0.912 Pathogenic MSH6 P52701 D1106W 1106 D W 0.97 Pathogenic MSH6 P52701 D1106Y 1106 D Y 0.964 Pathogenic MSH6 P52701 D1107A 1107 D A 0.126 Neutral MSH6 P52701 D1107C 1107 D C 0.756 Pathogenic MSH6 P52701 D1107E 1107 D E 0.068 Neutral MSH6 P52701 D1107F 1107 D F 0.938 Pathogenic MSH6 P52701 D1107G 1107 D G 0.178 Neutral MSH6 P52701 D1107H 1107 D H 0.448 Neutral MSH6 P52701 D1107I 1107 D I 0.908 Pathogenic MSH6 P52701 D1107K 1107 D K 0.728 Pathogenic MSH6 P52701 D1107L 1107 D L 0.914 Pathogenic MSH6 P52701 D1107M 1107 D M 0.746 Pathogenic MSH6 P52701 D1107N 1107 D N 0.014 Neutral MSH6 P52701 D1107P 1107 D P 0.374 Neutral MSH6 P52701 D1107Q 1107 D Q 0.492 Neutral MSH6 P52701 D1107R 1107 D R 0.764 Pathogenic MSH6 P52701 D1107S 1107 D S 0.012 Neutral MSH6 P52701 D1107T 1107 D T 0.054 Neutral MSH6 P52701 D1107V 1107 D V 0.936 Pathogenic MSH6 P52701 D1107W 1107 D W 0.974 Pathogenic MSH6 P52701 D1107Y 1107 D Y 0.968 Pathogenic MSH6 P52701 F1108A 1108 F A 0.51 Pathogenic MSH6 P52701 F1108C 1108 F C 0.72 Pathogenic MSH6 P52701 F1108D 1108 F D 0.802 Pathogenic MSH6 P52701 F1108E 1108 F E 0.848 Pathogenic MSH6 P52701 F1108G 1108 F G 0.51 Pathogenic MSH6 P52701 F1108H 1108 F H 0.756 Pathogenic MSH6 P52701 F1108I 1108 F I 0.194 Neutral MSH6 P52701 F1108K 1108 F K 0.834 Pathogenic MSH6 P52701 F1108L 1108 F L 0.184 Neutral MSH6 P52701 F1108M 1108 F M 0.778 Pathogenic MSH6 P52701 F1108N 1108 F N 0.74 Pathogenic MSH6 P52701 F1108P 1108 F P 0.964 Pathogenic MSH6 P52701 F1108Q 1108 F Q 0.75 Pathogenic MSH6 P52701 F1108R 1108 F R 0.9 Pathogenic MSH6 P52701 F1108S 1108 F S 0.862 Pathogenic MSH6 P52701 F1108T 1108 F T 0.578 Pathogenic MSH6 P52701 F1108V 1108 F V 0.768 Pathogenic MSH6 P52701 F1108W 1108 F W 0.85 Pathogenic MSH6 P52701 F1108Y 1108 F Y 0.192 Neutral MSH6 P52701 I1109A 1109 I A 0.626 Pathogenic MSH6 P52701 I1109C 1109 I C 0.706 Pathogenic MSH6 P52701 I1109D 1109 I D 0.774 Pathogenic MSH6 P52701 I1109E 1109 I E 0.774 Pathogenic MSH6 P52701 I1109F 1109 I F 0.87 Pathogenic MSH6 P52701 I1109G 1109 I G 0.858 Pathogenic MSH6 P52701 I1109H 1109 I H 0.9 Pathogenic MSH6 P52701 I1109K 1109 I K 0.844 Pathogenic MSH6 P52701 I1109L 1109 I L 0.618 Pathogenic MSH6 P52701 I1109M 1109 I M 0.676 Pathogenic MSH6 P52701 I1109N 1109 I N 0.796 Pathogenic MSH6 P52701 I1109P 1109 I P 0.93 Pathogenic MSH6 P52701 I1109Q 1109 I Q 0.804 Pathogenic MSH6 P52701 I1109R 1109 I R 0.88 Pathogenic MSH6 P52701 I1109S 1109 I S 0.688 Pathogenic MSH6 P52701 I1109T 1109 I T 0.092 Neutral MSH6 P52701 I1109V 1109 I V 0.082 Neutral MSH6 P52701 I1109W 1109 I W 0.928 Pathogenic MSH6 P52701 I1109Y 1109 I Y 0.902 Pathogenic MSH6 P52701 Y111A 111 Y A 0.082 Neutral MSH6 P52701 Y111C 111 Y C 0.052 Neutral MSH6 P52701 Y111D 111 Y D 0.186 Neutral MSH6 P52701 Y111E 111 Y E 0.186 Neutral MSH6 P52701 Y111F 111 Y F 0.058 Neutral MSH6 P52701 Y111G 111 Y G 0.122 Neutral MSH6 P52701 Y111H 111 Y H 0.054 Neutral MSH6 P52701 Y111I 111 Y I 0.094 Neutral MSH6 P52701 Y111K 111 Y K 0.176 Neutral MSH6 P52701 Y111L 111 Y L 0.04 Neutral MSH6 P52701 Y111M 111 Y M 0.08 Neutral MSH6 P52701 Y111N 111 Y N 0.118 Neutral MSH6 P52701 Y111P 111 Y P 0.074 Neutral MSH6 P52701 Y111Q 111 Y Q 0.112 Neutral MSH6 P52701 Y111R 111 Y R 0.166 Neutral MSH6 P52701 Y111S 111 Y S 0.122 Neutral MSH6 P52701 Y111T 111 Y T 0.126 Neutral MSH6 P52701 Y111V 111 Y V 0.014 Neutral MSH6 P52701 Y111W 111 Y W 0.05 Neutral MSH6 P52701 P1110A 1110 P A 0.192 Neutral MSH6 P52701 P1110C 1110 P C 0.892 Pathogenic MSH6 P52701 P1110D 1110 P D 0.854 Pathogenic MSH6 P52701 P1110E 1110 P E 0.942 Pathogenic MSH6 P52701 P1110F 1110 P F 0.99 Pathogenic MSH6 P52701 P1110G 1110 P G 0.684 Pathogenic MSH6 P52701 P1110H 1110 P H 0.966 Pathogenic MSH6 P52701 P1110I 1110 P I 0.91 Pathogenic MSH6 P52701 P1110K 1110 P K 0.928 Pathogenic MSH6 P52701 P1110L 1110 P L 0.972 Pathogenic MSH6 P52701 P1110M 1110 P M 0.946 Pathogenic MSH6 P52701 P1110N 1110 P N 0.776 Pathogenic MSH6 P52701 P1110Q 1110 P Q 0.864 Pathogenic MSH6 P52701 P1110R 1110 P R 0.976 Pathogenic MSH6 P52701 P1110S 1110 P S 0.076 Neutral MSH6 P52701 P1110T 1110 P T 0.382 Neutral MSH6 P52701 P1110V 1110 P V 0.814 Pathogenic MSH6 P52701 P1110W 1110 P W 0.922 Pathogenic MSH6 P52701 P1110Y 1110 P Y 0.916 Pathogenic MSH6 P52701 N1111A 1111 N A 0.8 Pathogenic MSH6 P52701 N1111C 1111 N C 0.776 Pathogenic MSH6 P52701 N1111D 1111 N D 0.74 Pathogenic MSH6 P52701 N1111E 1111 N E 0.618 Pathogenic MSH6 P52701 N1111F 1111 N F 0.958 Pathogenic MSH6 P52701 N1111G 1111 N G 0.722 Pathogenic MSH6 P52701 N1111H 1111 N H 0.874 Pathogenic MSH6 P52701 N1111I 1111 N I 0.948 Pathogenic MSH6 P52701 N1111K 1111 N K 0.936 Pathogenic MSH6 P52701 N1111L 1111 N L 0.96 Pathogenic MSH6 P52701 N1111M 1111 N M 0.96 Pathogenic MSH6 P52701 N1111P 1111 N P 0.872 Pathogenic MSH6 P52701 N1111Q 1111 N Q 0.806 Pathogenic MSH6 P52701 N1111R 1111 N R 0.95 Pathogenic MSH6 P52701 N1111S 1111 N S 0.724 Pathogenic MSH6 P52701 N1111T 1111 N T 0.544 Pathogenic MSH6 P52701 N1111V 1111 N V 0.992 Pathogenic MSH6 P52701 N1111W 1111 N W 0.972 Pathogenic MSH6 P52701 N1111Y 1111 N Y 0.968 Pathogenic MSH6 P52701 D1112A 1112 D A 0.764 Pathogenic MSH6 P52701 D1112C 1112 D C 0.922 Pathogenic MSH6 P52701 D1112E 1112 D E 0.968 Pathogenic MSH6 P52701 D1112F 1112 D F 0.986 Pathogenic MSH6 P52701 D1112G 1112 D G 0.162 Neutral MSH6 P52701 D1112H 1112 D H 0.652 Pathogenic MSH6 P52701 D1112I 1112 D I 0.972 Pathogenic MSH6 P52701 D1112K 1112 D K 0.986 Pathogenic MSH6 P52701 D1112L 1112 D L 0.982 Pathogenic MSH6 P52701 D1112M 1112 D M 0.962 Pathogenic MSH6 P52701 D1112N 1112 D N 0.162 Neutral MSH6 P52701 D1112P 1112 D P 0.912 Pathogenic MSH6 P52701 D1112Q 1112 D Q 0.762 Pathogenic MSH6 P52701 D1112R 1112 D R 0.942 Pathogenic MSH6 P52701 D1112S 1112 D S 0.108 Neutral MSH6 P52701 D1112T 1112 D T 0.288 Neutral MSH6 P52701 D1112V 1112 D V 0.992 Pathogenic MSH6 P52701 D1112W 1112 D W 0.986 Pathogenic MSH6 P52701 D1112Y 1112 D Y 0.98 Pathogenic MSH6 P52701 I1113A 1113 I A 0.048 Neutral MSH6 P52701 I1113C 1113 I C 0.434 Neutral MSH6 P52701 I1113D 1113 I D 0.612 Pathogenic MSH6 P52701 I1113E 1113 I E 0.6 Pathogenic MSH6 P52701 I1113F 1113 I F 0.516 Pathogenic MSH6 P52701 I1113G 1113 I G 0.588 Pathogenic MSH6 P52701 I1113H 1113 I H 0.512 Pathogenic MSH6 P52701 I1113K 1113 I K 0.598 Pathogenic MSH6 P52701 I1113L 1113 I L 0.002 Neutral MSH6 P52701 I1113M 1113 I M 0.366 Neutral MSH6 P52701 I1113N 1113 I N 0.656 Pathogenic MSH6 P52701 I1113P 1113 I P 0.716 Pathogenic MSH6 P52701 I1113Q 1113 I Q 0.636 Pathogenic MSH6 P52701 I1113R 1113 I R 0.814 Pathogenic MSH6 P52701 I1113S 1113 I S 0.092 Neutral MSH6 P52701 I1113T 1113 I T 0.016 Neutral MSH6 P52701 I1113V 1113 I V 0.002 Neutral MSH6 P52701 I1113W 1113 I W 0.858 Pathogenic MSH6 P52701 I1113Y 1113 I Y 0.85 Pathogenic MSH6 P52701 L1114A 1114 L A 0.064 Neutral MSH6 P52701 L1114C 1114 L C 0.048 Neutral MSH6 P52701 L1114D 1114 L D 0.158 Neutral MSH6 P52701 L1114E 1114 L E 0.028 Neutral MSH6 P52701 L1114F 1114 L F 0.12 Neutral MSH6 P52701 L1114G 1114 L G 0.144 Neutral MSH6 P52701 L1114H 1114 L H 0.022 Neutral MSH6 P52701 L1114I 1114 L I 0.002 Neutral MSH6 P52701 L1114K 1114 L K 0.084 Neutral MSH6 P52701 L1114M 1114 L M 0.012 Neutral MSH6 P52701 L1114N 1114 L N 0.074 Neutral MSH6 P52701 L1114P 1114 L P 0.24 Neutral MSH6 P52701 L1114Q 1114 L Q 0.004 Neutral MSH6 P52701 L1114R 1114 L R 0.218 Neutral MSH6 P52701 L1114S 1114 L S 0.01 Neutral MSH6 P52701 L1114T 1114 L T 0.03 Neutral MSH6 P52701 L1114V 1114 L V 0 Neutral MSH6 P52701 L1114W 1114 L W 0.334 Neutral MSH6 P52701 L1114Y 1114 L Y 0.282 Neutral MSH6 P52701 I1115A 1115 I A 0.114 Neutral MSH6 P52701 I1115C 1115 I C 0.142 Neutral MSH6 P52701 I1115D 1115 I D 0.222 Neutral MSH6 P52701 I1115E 1115 I E 0.04 Neutral MSH6 P52701 I1115F 1115 I F 0.336 Neutral MSH6 P52701 I1115G 1115 I G 0.284 Neutral MSH6 P52701 I1115H 1115 I H 0.146 Neutral MSH6 P52701 I1115K 1115 I K 0.212 Neutral MSH6 P52701 I1115L 1115 I L 0 Neutral MSH6 P52701 I1115M 1115 I M 0.046 Neutral MSH6 P52701 I1115N 1115 I N 0.266 Neutral MSH6 P52701 I1115P 1115 I P 0.254 Neutral MSH6 P52701 I1115Q 1115 I Q 0.262 Neutral MSH6 P52701 I1115R 1115 I R 0.468 Neutral MSH6 P52701 I1115S 1115 I S 0.216 Neutral MSH6 P52701 I1115T 1115 I T 0.266 Neutral MSH6 P52701 I1115V 1115 I V 0 Neutral MSH6 P52701 I1115W 1115 I W 0.536 Pathogenic MSH6 P52701 I1115Y 1115 I Y 0.494 Neutral MSH6 P52701 G1116A 1116 G A 0.048 Neutral MSH6 P52701 G1116C 1116 G C 0.64 Pathogenic MSH6 P52701 G1116D 1116 G D 0.576 Pathogenic MSH6 P52701 G1116E 1116 G E 0.596 Pathogenic MSH6 P52701 G1116F 1116 G F 0.918 Pathogenic MSH6 P52701 G1116H 1116 G H 0.914 Pathogenic MSH6 P52701 G1116I 1116 G I 0.878 Pathogenic MSH6 P52701 G1116K 1116 G K 0.914 Pathogenic MSH6 P52701 G1116L 1116 G L 0.876 Pathogenic MSH6 P52701 G1116M 1116 G M 0.91 Pathogenic MSH6 P52701 G1116N 1116 G N 0.572 Pathogenic MSH6 P52701 G1116P 1116 G P 0.844 Pathogenic MSH6 P52701 G1116Q 1116 G Q 0.724 Pathogenic MSH6 P52701 G1116R 1116 G R 0.922 Pathogenic MSH6 P52701 G1116S 1116 G S 0.592 Pathogenic MSH6 P52701 G1116T 1116 G T 0.758 Pathogenic MSH6 P52701 G1116V 1116 G V 0.878 Pathogenic MSH6 P52701 G1116W 1116 G W 0.914 Pathogenic MSH6 P52701 G1116Y 1116 G Y 0.904 Pathogenic MSH6 P52701 C1117A 1117 C A 0.078 Neutral MSH6 P52701 C1117D 1117 C D 0.056 Neutral MSH6 P52701 C1117E 1117 C E 0.116 Neutral MSH6 P52701 C1117F 1117 C F 0.436 Neutral MSH6 P52701 C1117G 1117 C G 0.004 Neutral MSH6 P52701 C1117H 1117 C H 0.244 Neutral MSH6 P52701 C1117I 1117 C I 0.074 Neutral MSH6 P52701 C1117K 1117 C K 0.22 Neutral MSH6 P52701 C1117L 1117 C L 0.082 Neutral MSH6 P52701 C1117M 1117 C M 0.148 Neutral MSH6 P52701 C1117N 1117 C N 0.04 Neutral MSH6 P52701 C1117P 1117 C P 0.278 Neutral MSH6 P52701 C1117Q 1117 C Q 0.186 Neutral MSH6 P52701 C1117R 1117 C R 0.218 Neutral MSH6 P52701 C1117S 1117 C S 0.014 Neutral MSH6 P52701 C1117T 1117 C T 0 Neutral MSH6 P52701 C1117V 1117 C V 0.086 Neutral MSH6 P52701 C1117W 1117 C W 0.514 Pathogenic MSH6 P52701 C1117Y 1117 C Y 0.468 Neutral MSH6 P52701 E1118A 1118 E A 0.066 Neutral MSH6 P52701 E1118C 1118 E C 0.068 Neutral MSH6 P52701 E1118D 1118 E D 0.002 Neutral MSH6 P52701 E1118F 1118 E F 0.272 Neutral MSH6 P52701 E1118G 1118 E G 0.002 Neutral MSH6 P52701 E1118H 1118 E H 0.104 Neutral MSH6 P52701 E1118I 1118 E I 0.284 Neutral MSH6 P52701 E1118K 1118 E K 0.002 Neutral MSH6 P52701 E1118L 1118 E L 0.138 Neutral MSH6 P52701 E1118M 1118 E M 0.164 Neutral MSH6 P52701 E1118N 1118 E N 0.056 Neutral MSH6 P52701 E1118P 1118 E P 0.042 Neutral MSH6 P52701 E1118Q 1118 E Q 0.012 Neutral MSH6 P52701 E1118R 1118 E R 0.036 Neutral MSH6 P52701 E1118S 1118 E S 0.018 Neutral MSH6 P52701 E1118T 1118 E T 0.168 Neutral MSH6 P52701 E1118V 1118 E V 0.142 Neutral MSH6 P52701 E1118W 1118 E W 0.43 Neutral MSH6 P52701 E1118Y 1118 E Y 0.338 Neutral MSH6 P52701 E1119A 1119 E A 0.212 Neutral MSH6 P52701 E1119C 1119 E C 0.068 Neutral MSH6 P52701 E1119D 1119 E D 0 Neutral MSH6 P52701 E1119F 1119 E F 0.282 Neutral MSH6 P52701 E1119G 1119 E G 0 Neutral MSH6 P52701 E1119H 1119 E H 0.106 Neutral MSH6 P52701 E1119I 1119 E I 0.294 Neutral MSH6 P52701 E1119K 1119 E K 0.068 Neutral MSH6 P52701 E1119L 1119 E L 0.146 Neutral MSH6 P52701 E1119M 1119 E M 0.172 Neutral MSH6 P52701 E1119N 1119 E N 0.002 Neutral MSH6 P52701 E1119P 1119 E P 0.308 Neutral MSH6 P52701 E1119Q 1119 E Q 0.056 Neutral MSH6 P52701 E1119R 1119 E R 0.046 Neutral MSH6 P52701 E1119S 1119 E S 0.158 Neutral MSH6 P52701 E1119T 1119 E T 0.144 Neutral MSH6 P52701 E1119V 1119 E V 0.242 Neutral MSH6 P52701 E1119W 1119 E W 0.448 Neutral MSH6 P52701 E1119Y 1119 E Y 0.426 Neutral MSH6 P52701 N112A 112 N A 0.052 Neutral MSH6 P52701 N112C 112 N C 0.152 Neutral MSH6 P52701 N112D 112 N D 0.008 Neutral MSH6 P52701 N112E 112 N E 0.098 Neutral MSH6 P52701 N112F 112 N F 0.358 Neutral MSH6 P52701 N112G 112 N G 0.164 Neutral MSH6 P52701 N112H 112 N H 0.236 Neutral MSH6 P52701 N112I 112 N I 0.274 Neutral MSH6 P52701 N112K 112 N K 0.038 Neutral MSH6 P52701 N112L 112 N L 0.176 Neutral MSH6 P52701 N112M 112 N M 0.228 Neutral MSH6 P52701 N112P 112 N P 0.128 Neutral MSH6 P52701 N112Q 112 N Q 0.116 Neutral MSH6 P52701 N112R 112 N R 0.142 Neutral MSH6 P52701 N112S 112 N S 0.148 Neutral MSH6 P52701 N112T 112 N T 0.118 Neutral MSH6 P52701 N112V 112 N V 0.288 Neutral MSH6 P52701 N112W 112 N W 0.464 Neutral MSH6 P52701 N112Y 112 N Y 0.42 Neutral MSH6 P52701 E1120A 1120 E A 0.212 Neutral MSH6 P52701 E1120C 1120 E C 0.068 Neutral MSH6 P52701 E1120D 1120 E D 0 Neutral MSH6 P52701 E1120F 1120 E F 0.312 Neutral MSH6 P52701 E1120G 1120 E G 0 Neutral MSH6 P52701 E1120H 1120 E H 0.104 Neutral MSH6 P52701 E1120I 1120 E I 0.284 Neutral MSH6 P52701 E1120K 1120 E K 0.144 Neutral MSH6 P52701 E1120L 1120 E L 0.286 Neutral MSH6 P52701 E1120M 1120 E M 0.164 Neutral MSH6 P52701 E1120N 1120 E N 0.04 Neutral MSH6 P52701 E1120P 1120 E P 0.282 Neutral MSH6 P52701 E1120Q 1120 E Q 0 Neutral MSH6 P52701 E1120R 1120 E R 0.046 Neutral MSH6 P52701 E1120S 1120 E S 0.014 Neutral MSH6 P52701 E1120T 1120 E T 0.02 Neutral MSH6 P52701 E1120V 1120 E V 0.142 Neutral MSH6 P52701 E1120W 1120 E W 0.43 Neutral MSH6 P52701 E1120Y 1120 E Y 0.338 Neutral MSH6 P52701 E1121A 1121 E A 0.066 Neutral MSH6 P52701 E1121C 1121 E C 0.068 Neutral MSH6 P52701 E1121D 1121 E D 0 Neutral MSH6 P52701 E1121F 1121 E F 0.272 Neutral MSH6 P52701 E1121G 1121 E G 0 Neutral MSH6 P52701 E1121H 1121 E H 0.162 Neutral MSH6 P52701 E1121I 1121 E I 0.284 Neutral MSH6 P52701 E1121K 1121 E K 0.068 Neutral MSH6 P52701 E1121L 1121 E L 0.286 Neutral MSH6 P52701 E1121M 1121 E M 0.164 Neutral MSH6 P52701 E1121N 1121 E N 0.002 Neutral MSH6 P52701 E1121P 1121 E P 0.124 Neutral MSH6 P52701 E1121Q 1121 E Q 0.056 Neutral MSH6 P52701 E1121R 1121 E R 0.036 Neutral MSH6 P52701 E1121S 1121 E S 0.014 Neutral MSH6 P52701 E1121T 1121 E T 0.006 Neutral MSH6 P52701 E1121V 1121 E V 0.142 Neutral MSH6 P52701 E1121W 1121 E W 0.43 Neutral MSH6 P52701 E1121Y 1121 E Y 0.338 Neutral MSH6 P52701 Q1122A 1122 Q A 0.046 Neutral MSH6 P52701 Q1122C 1122 Q C 0.16 Neutral MSH6 P52701 Q1122D 1122 Q D 0 Neutral MSH6 P52701 Q1122E 1122 Q E 0.006 Neutral MSH6 P52701 Q1122F 1122 Q F 0.426 Neutral MSH6 P52701 Q1122G 1122 Q G 0.042 Neutral MSH6 P52701 Q1122H 1122 Q H 0.096 Neutral MSH6 P52701 Q1122I 1122 Q I 0.526 Pathogenic MSH6 P52701 Q1122K 1122 Q K 0.028 Neutral MSH6 P52701 Q1122L 1122 Q L 0.394 Neutral MSH6 P52701 Q1122M 1122 Q M 0.332 Neutral MSH6 P52701 Q1122N 1122 Q N 0.022 Neutral MSH6 P52701 Q1122P 1122 Q P 0.536 Pathogenic MSH6 P52701 Q1122R 1122 Q R 0.006 Neutral MSH6 P52701 Q1122S 1122 Q S 0.042 Neutral MSH6 P52701 Q1122T 1122 Q T 0.004 Neutral MSH6 P52701 Q1122V 1122 Q V 0.416 Neutral MSH6 P52701 Q1122W 1122 Q W 0.684 Pathogenic MSH6 P52701 Q1122Y 1122 Q Y 0.612 Pathogenic MSH6 P52701 E1123A 1123 E A 0.066 Neutral MSH6 P52701 E1123C 1123 E C 0.068 Neutral MSH6 P52701 E1123D 1123 E D 0 Neutral MSH6 P52701 E1123F 1123 E F 0.282 Neutral MSH6 P52701 E1123G 1123 E G 0.004 Neutral MSH6 P52701 E1123H 1123 E H 0.018 Neutral MSH6 P52701 E1123I 1123 E I 0.294 Neutral MSH6 P52701 E1123K 1123 E K 0.002 Neutral MSH6 P52701 E1123L 1123 E L 0.296 Neutral MSH6 P52701 E1123M 1123 E M 0.02 Neutral MSH6 P52701 E1123N 1123 E N 0.002 Neutral MSH6 P52701 E1123P 1123 E P 0.044 Neutral MSH6 P52701 E1123Q 1123 E Q 0.012 Neutral MSH6 P52701 E1123R 1123 E R 0.032 Neutral MSH6 P52701 E1123S 1123 E S 0.014 Neutral MSH6 P52701 E1123T 1123 E T 0.008 Neutral MSH6 P52701 E1123V 1123 E V 0.146 Neutral MSH6 P52701 E1123W 1123 E W 0.448 Neutral MSH6 P52701 E1123Y 1123 E Y 0.358 Neutral MSH6 P52701 N1124A 1124 N A 0.052 Neutral MSH6 P52701 N1124C 1124 N C 0.148 Neutral MSH6 P52701 N1124D 1124 N D 0.008 Neutral MSH6 P52701 N1124E 1124 N E 0.086 Neutral MSH6 P52701 N1124F 1124 N F 0.418 Neutral MSH6 P52701 N1124G 1124 N G 0.02 Neutral MSH6 P52701 N1124H 1124 N H 0.024 Neutral MSH6 P52701 N1124I 1124 N I 0.266 Neutral MSH6 P52701 N1124K 1124 N K 0.038 Neutral MSH6 P52701 N1124L 1124 N L 0.272 Neutral MSH6 P52701 N1124M 1124 N M 0.22 Neutral MSH6 P52701 N1124P 1124 N P 0.228 Neutral MSH6 P52701 N1124Q 1124 N Q 0.114 Neutral MSH6 P52701 N1124R 1124 N R 0.136 Neutral MSH6 P52701 N1124S 1124 N S 0 Neutral MSH6 P52701 N1124T 1124 N T 0.08 Neutral MSH6 P52701 N1124V 1124 N V 0.262 Neutral MSH6 P52701 N1124W 1124 N W 0.42 Neutral MSH6 P52701 N1124Y 1124 N Y 0.45 Neutral MSH6 P52701 G1125A 1125 G A 0.004 Neutral MSH6 P52701 G1125C 1125 G C 0.14 Neutral MSH6 P52701 G1125D 1125 G D 0.136 Neutral MSH6 P52701 G1125E 1125 G E 0.19 Neutral MSH6 P52701 G1125F 1125 G F 0.422 Neutral MSH6 P52701 G1125H 1125 G H 0.37 Neutral MSH6 P52701 G1125I 1125 G I 0.412 Neutral MSH6 P52701 G1125K 1125 G K 0.312 Neutral MSH6 P52701 G1125L 1125 G L 0.37 Neutral MSH6 P52701 G1125M 1125 G M 0.422 Neutral MSH6 P52701 G1125N 1125 G N 0.168 Neutral MSH6 P52701 G1125P 1125 G P 0.402 Neutral MSH6 P52701 G1125Q 1125 G Q 0.192 Neutral MSH6 P52701 G1125R 1125 G R 0.362 Neutral MSH6 P52701 G1125S 1125 G S 0.016 Neutral MSH6 P52701 G1125T 1125 G T 0.26 Neutral MSH6 P52701 G1125V 1125 G V 0.318 Neutral MSH6 P52701 G1125W 1125 G W 0.458 Neutral MSH6 P52701 G1125Y 1125 G Y 0.5 Pathogenic MSH6 P52701 K1126A 1126 K A 0.028 Neutral MSH6 P52701 K1126C 1126 K C 0.036 Neutral MSH6 P52701 K1126D 1126 K D 0.002 Neutral MSH6 P52701 K1126E 1126 K E 0.004 Neutral MSH6 P52701 K1126F 1126 K F 0.23 Neutral MSH6 P52701 K1126G 1126 K G 0.042 Neutral MSH6 P52701 K1126H 1126 K H 0.018 Neutral MSH6 P52701 K1126I 1126 K I 0.222 Neutral MSH6 P52701 K1126L 1126 K L 0.052 Neutral MSH6 P52701 K1126M 1126 K M 0.106 Neutral MSH6 P52701 K1126N 1126 K N 0.006 Neutral MSH6 P52701 K1126P 1126 K P 0.03 Neutral MSH6 P52701 K1126Q 1126 K Q 0.006 Neutral MSH6 P52701 K1126R 1126 K R 0.002 Neutral MSH6 P52701 K1126S 1126 K S 0.014 Neutral MSH6 P52701 K1126T 1126 K T 0.092 Neutral MSH6 P52701 K1126V 1126 K V 0.18 Neutral MSH6 P52701 K1126W 1126 K W 0.396 Neutral MSH6 P52701 K1126Y 1126 K Y 0.326 Neutral MSH6 P52701 A1127C 1127 A C 0.426 Neutral MSH6 P52701 A1127D 1127 A D 0.584 Pathogenic MSH6 P52701 A1127E 1127 A E 0.624 Pathogenic MSH6 P52701 A1127F 1127 A F 0.81 Pathogenic MSH6 P52701 A1127G 1127 A G 0.012 Neutral MSH6 P52701 A1127H 1127 A H 0.636 Pathogenic MSH6 P52701 A1127I 1127 A I 0.756 Pathogenic MSH6 P52701 A1127K 1127 A K 0.698 Pathogenic MSH6 P52701 A1127L 1127 A L 0.748 Pathogenic MSH6 P52701 A1127M 1127 A M 0.604 Pathogenic MSH6 P52701 A1127N 1127 A N 0.472 Neutral MSH6 P52701 A1127P 1127 A P 0.068 Neutral MSH6 P52701 A1127Q 1127 A Q 0.632 Pathogenic MSH6 P52701 A1127R 1127 A R 0.714 Pathogenic MSH6 P52701 A1127S 1127 A S 0.01 Neutral MSH6 P52701 A1127T 1127 A T 0.156 Neutral MSH6 P52701 A1127V 1127 A V 0.132 Neutral MSH6 P52701 A1127W 1127 A W 0.834 Pathogenic MSH6 P52701 A1127Y 1127 A Y 0.832 Pathogenic MSH6 P52701 Y1128A 1128 Y A 0.046 Neutral MSH6 P52701 Y1128C 1128 Y C 0.138 Neutral MSH6 P52701 Y1128D 1128 Y D 0.166 Neutral MSH6 P52701 Y1128E 1128 Y E 0.184 Neutral MSH6 P52701 Y1128F 1128 Y F 0.01 Neutral MSH6 P52701 Y1128G 1128 Y G 0.122 Neutral MSH6 P52701 Y1128H 1128 Y H 0.052 Neutral MSH6 P52701 Y1128I 1128 Y I 0.038 Neutral MSH6 P52701 Y1128K 1128 Y K 0.098 Neutral MSH6 P52701 Y1128L 1128 Y L 0.012 Neutral MSH6 P52701 Y1128M 1128 Y M 0.012 Neutral MSH6 P52701 Y1128N 1128 Y N 0.07 Neutral MSH6 P52701 Y1128P 1128 Y P 0.032 Neutral MSH6 P52701 Y1128Q 1128 Y Q 0.064 Neutral MSH6 P52701 Y1128R 1128 Y R 0.038 Neutral MSH6 P52701 Y1128S 1128 Y S 0.096 Neutral MSH6 P52701 Y1128T 1128 Y T 0.052 Neutral MSH6 P52701 Y1128V 1128 Y V 0.22 Neutral MSH6 P52701 Y1128W 1128 Y W 0.048 Neutral MSH6 P52701 C1129A 1129 C A 0.106 Neutral MSH6 P52701 C1129D 1129 C D 0.114 Neutral MSH6 P52701 C1129E 1129 C E 0.216 Neutral MSH6 P52701 C1129F 1129 C F 0.422 Neutral MSH6 P52701 C1129G 1129 C G 0.238 Neutral MSH6 P52701 C1129H 1129 C H 0.364 Neutral MSH6 P52701 C1129I 1129 C I 0.096 Neutral MSH6 P52701 C1129K 1129 C K 0.326 Neutral MSH6 P52701 C1129L 1129 C L 0.044 Neutral MSH6 P52701 C1129M 1129 C M 0.028 Neutral MSH6 P52701 C1129N 1129 C N 0.074 Neutral MSH6 P52701 C1129P 1129 C P 0.442 Neutral MSH6 P52701 C1129Q 1129 C Q 0.222 Neutral MSH6 P52701 C1129R 1129 C R 0.482 Neutral MSH6 P52701 C1129S 1129 C S 0.014 Neutral MSH6 P52701 C1129T 1129 C T 0.024 Neutral MSH6 P52701 C1129V 1129 C V 0.02 Neutral MSH6 P52701 C1129W 1129 C W 0.748 Pathogenic MSH6 P52701 C1129Y 1129 C Y 0.714 Pathogenic MSH6 P52701 H113A 113 H A 0.116 Neutral MSH6 P52701 H113C 113 H C 0.078 Neutral MSH6 P52701 H113D 113 H D 0.058 Neutral MSH6 P52701 H113E 113 H E 0.098 Neutral MSH6 P52701 H113F 113 H F 0.362 Neutral MSH6 P52701 H113G 113 H G 0.166 Neutral MSH6 P52701 H113I 113 H I 0.418 Neutral MSH6 P52701 H113K 113 H K 0.194 Neutral MSH6 P52701 H113L 113 H L 0.372 Neutral MSH6 P52701 H113M 113 H M 0.2 Neutral MSH6 P52701 H113N 113 H N 0.09 Neutral MSH6 P52701 H113P 113 H P 0.452 Neutral MSH6 P52701 H113Q 113 H Q 0.008 Neutral MSH6 P52701 H113R 113 H R 0.082 Neutral MSH6 P52701 H113S 113 H S 0.222 Neutral MSH6 P52701 H113T 113 H T 0.242 Neutral MSH6 P52701 H113V 113 H V 0.232 Neutral MSH6 P52701 H113W 113 H W 0.662 Pathogenic MSH6 P52701 H113Y 113 H Y 0.428 Neutral MSH6 P52701 V1130A 1130 V A 0.04 Neutral MSH6 P52701 V1130C 1130 V C 0.188 Neutral MSH6 P52701 V1130D 1130 V D 0.5 Pathogenic MSH6 P52701 V1130E 1130 V E 0.614 Pathogenic MSH6 P52701 V1130F 1130 V F 0.68 Pathogenic MSH6 P52701 V1130G 1130 V G 0.566 Pathogenic MSH6 P52701 V1130H 1130 V H 0.432 Neutral MSH6 P52701 V1130I 1130 V I 0.074 Neutral MSH6 P52701 V1130K 1130 V K 0.64 Pathogenic MSH6 P52701 V1130L 1130 V L 0.07 Neutral MSH6 P52701 V1130M 1130 V M 0.056 Neutral MSH6 P52701 V1130N 1130 V N 0.538 Pathogenic MSH6 P52701 V1130P 1130 V P 0.77 Pathogenic MSH6 P52701 V1130Q 1130 V Q 0.632 Pathogenic MSH6 P52701 V1130R 1130 V R 0.786 Pathogenic MSH6 P52701 V1130S 1130 V S 0.366 Neutral MSH6 P52701 V1130T 1130 V T 0.15 Neutral MSH6 P52701 V1130W 1130 V W 0.778 Pathogenic MSH6 P52701 V1130Y 1130 V Y 0.758 Pathogenic MSH6 P52701 L1131A 1131 L A 0.702 Pathogenic MSH6 P52701 L1131C 1131 L C 0.806 Pathogenic MSH6 P52701 L1131D 1131 L D 0.878 Pathogenic MSH6 P52701 L1131E 1131 L E 0.86 Pathogenic MSH6 P52701 L1131F 1131 L F 0.828 Pathogenic MSH6 P52701 L1131G 1131 L G 0.848 Pathogenic MSH6 P52701 L1131H 1131 L H 0.898 Pathogenic MSH6 P52701 L1131I 1131 L I 0.278 Neutral MSH6 P52701 L1131K 1131 L K 0.676 Pathogenic MSH6 P52701 L1131M 1131 L M 0.552 Pathogenic MSH6 P52701 L1131N 1131 L N 0.786 Pathogenic MSH6 P52701 L1131P 1131 L P 0.97 Pathogenic MSH6 P52701 L1131Q 1131 L Q 0.75 Pathogenic MSH6 P52701 L1131R 1131 L R 0.97 Pathogenic MSH6 P52701 L1131S 1131 L S 0.66 Pathogenic MSH6 P52701 L1131T 1131 L T 0.58 Pathogenic MSH6 P52701 L1131V 1131 L V 0.036 Neutral MSH6 P52701 L1131W 1131 L W 0.848 Pathogenic MSH6 P52701 L1131Y 1131 L Y 0.87 Pathogenic MSH6 P52701 V1132A 1132 V A 0.346 Neutral MSH6 P52701 V1132C 1132 V C 0.712 Pathogenic MSH6 P52701 V1132D 1132 V D 0.868 Pathogenic MSH6 P52701 V1132E 1132 V E 0.982 Pathogenic MSH6 P52701 V1132F 1132 V F 0.872 Pathogenic MSH6 P52701 V1132G 1132 V G 0.908 Pathogenic MSH6 P52701 V1132H 1132 V H 0.814 Pathogenic MSH6 P52701 V1132I 1132 V I 0.188 Neutral MSH6 P52701 V1132K 1132 V K 0.976 Pathogenic MSH6 P52701 V1132L 1132 V L 0.174 Neutral MSH6 P52701 V1132M 1132 V M 0.812 Pathogenic MSH6 P52701 V1132N 1132 V N 0.934 Pathogenic MSH6 P52701 V1132P 1132 V P 0.976 Pathogenic MSH6 P52701 V1132Q 1132 V Q 0.992 Pathogenic MSH6 P52701 V1132R 1132 V R 0.96 Pathogenic MSH6 P52701 V1132S 1132 V S 0.746 Pathogenic MSH6 P52701 V1132T 1132 V T 0.748 Pathogenic MSH6 P52701 V1132W 1132 V W 0.902 Pathogenic MSH6 P52701 V1132Y 1132 V Y 0.928 Pathogenic MSH6 P52701 T1133A 1133 T A 0.7 Pathogenic MSH6 P52701 T1133C 1133 T C 0.926 Pathogenic MSH6 P52701 T1133D 1133 T D 0.936 Pathogenic MSH6 P52701 T1133E 1133 T E 0.944 Pathogenic MSH6 P52701 T1133F 1133 T F 0.946 Pathogenic MSH6 P52701 T1133G 1133 T G 0.744 Pathogenic MSH6 P52701 T1133H 1133 T H 0.918 Pathogenic MSH6 P52701 T1133I 1133 T I 0.944 Pathogenic MSH6 P52701 T1133K 1133 T K 0.934 Pathogenic MSH6 P52701 T1133L 1133 T L 0.63 Pathogenic MSH6 P52701 T1133M 1133 T M 0.976 Pathogenic MSH6 P52701 T1133N 1133 T N 0.886 Pathogenic MSH6 P52701 T1133P 1133 T P 0.956 Pathogenic MSH6 P52701 T1133Q 1133 T Q 0.89 Pathogenic MSH6 P52701 T1133R 1133 T R 0.99 Pathogenic MSH6 P52701 T1133S 1133 T S 0.23 Neutral MSH6 P52701 T1133V 1133 T V 0.814 Pathogenic MSH6 P52701 T1133W 1133 T W 0.962 Pathogenic MSH6 P52701 T1133Y 1133 T Y 0.962 Pathogenic MSH6 P52701 G1134A 1134 G A 0.966 Pathogenic MSH6 P52701 G1134C 1134 G C 0.948 Pathogenic MSH6 P52701 G1134D 1134 G D 0.804 Pathogenic MSH6 P52701 G1134E 1134 G E 0.988 Pathogenic MSH6 P52701 G1134F 1134 G F 0.982 Pathogenic MSH6 P52701 G1134H 1134 G H 0.986 Pathogenic MSH6 P52701 G1134I 1134 G I 0.972 Pathogenic MSH6 P52701 G1134K 1134 G K 0.986 Pathogenic MSH6 P52701 G1134L 1134 G L 0.982 Pathogenic MSH6 P52701 G1134M 1134 G M 0.994 Pathogenic MSH6 P52701 G1134N 1134 G N 0.986 Pathogenic MSH6 P52701 G1134P 1134 G P 0.964 Pathogenic MSH6 P52701 G1134Q 1134 G Q 0.994 Pathogenic MSH6 P52701 G1134R 1134 G R 1 Pathogenic MSH6 P52701 G1134S 1134 G S 0.826 Pathogenic MSH6 P52701 G1134T 1134 G T 0.84 Pathogenic MSH6 P52701 G1134V 1134 G V 0.984 Pathogenic MSH6 P52701 G1134W 1134 G W 0.978 Pathogenic MSH6 P52701 G1134Y 1134 G Y 0.958 Pathogenic MSH6 P52701 P1135A 1135 P A 0.178 Neutral MSH6 P52701 P1135C 1135 P C 0.908 Pathogenic MSH6 P52701 P1135D 1135 P D 0.858 Pathogenic MSH6 P52701 P1135E 1135 P E 0.952 Pathogenic MSH6 P52701 P1135F 1135 P F 0.998 Pathogenic MSH6 P52701 P1135G 1135 P G 0.658 Pathogenic MSH6 P52701 P1135H 1135 P H 0.974 Pathogenic MSH6 P52701 P1135I 1135 P I 0.934 Pathogenic MSH6 P52701 P1135K 1135 P K 0.944 Pathogenic MSH6 P52701 P1135L 1135 P L 0.992 Pathogenic MSH6 P52701 P1135M 1135 P M 0.954 Pathogenic MSH6 P52701 P1135N 1135 P N 0.752 Pathogenic MSH6 P52701 P1135Q 1135 P Q 0.546 Pathogenic MSH6 P52701 P1135R 1135 P R 0.978 Pathogenic MSH6 P52701 P1135S 1135 P S 0.316 Neutral MSH6 P52701 P1135T 1135 P T 0.702 Pathogenic MSH6 P52701 P1135V 1135 P V 0.846 Pathogenic MSH6 P52701 P1135W 1135 P W 0.932 Pathogenic MSH6 P52701 P1135Y 1135 P Y 0.928 Pathogenic MSH6 P52701 N1136A 1136 N A 0.8 Pathogenic MSH6 P52701 N1136C 1136 N C 0.772 Pathogenic MSH6 P52701 N1136D 1136 N D 0.728 Pathogenic MSH6 P52701 N1136E 1136 N E 0.612 Pathogenic MSH6 P52701 N1136F 1136 N F 0.958 Pathogenic MSH6 P52701 N1136G 1136 N G 0.72 Pathogenic MSH6 P52701 N1136H 1136 N H 0.87 Pathogenic MSH6 P52701 N1136I 1136 N I 0.876 Pathogenic MSH6 P52701 N1136K 1136 N K 0.846 Pathogenic MSH6 P52701 N1136L 1136 N L 0.958 Pathogenic MSH6 P52701 N1136M 1136 N M 0.96 Pathogenic MSH6 P52701 N1136P 1136 N P 0.868 Pathogenic MSH6 P52701 N1136Q 1136 N Q 0.8 Pathogenic MSH6 P52701 N1136R 1136 N R 0.95 Pathogenic MSH6 P52701 N1136S 1136 N S 0.718 Pathogenic MSH6 P52701 N1136T 1136 N T 0.532 Pathogenic MSH6 P52701 N1136V 1136 N V 0.992 Pathogenic MSH6 P52701 N1136W 1136 N W 0.97 Pathogenic MSH6 P52701 N1136Y 1136 N Y 0.966 Pathogenic MSH6 P52701 M1137A 1137 M A 0.188 Neutral MSH6 P52701 M1137C 1137 M C 0.618 Pathogenic MSH6 P52701 M1137D 1137 M D 0.876 Pathogenic MSH6 P52701 M1137E 1137 M E 0.814 Pathogenic MSH6 P52701 M1137F 1137 M F 0.864 Pathogenic MSH6 P52701 M1137G 1137 M G 0.534 Pathogenic MSH6 P52701 M1137H 1137 M H 0.934 Pathogenic MSH6 P52701 M1137I 1137 M I 0.514 Pathogenic MSH6 P52701 M1137K 1137 M K 0.956 Pathogenic MSH6 P52701 M1137L 1137 M L 0.824 Pathogenic MSH6 P52701 M1137N 1137 M N 0.904 Pathogenic MSH6 P52701 M1137P 1137 M P 0.928 Pathogenic MSH6 P52701 M1137Q 1137 M Q 0.788 Pathogenic MSH6 P52701 M1137R 1137 M R 0.954 Pathogenic MSH6 P52701 M1137S 1137 M S 0.898 Pathogenic MSH6 P52701 M1137T 1137 M T 0.76 Pathogenic MSH6 P52701 M1137V 1137 M V 0.634 Pathogenic MSH6 P52701 M1137W 1137 M W 0.846 Pathogenic MSH6 P52701 M1137Y 1137 M Y 0.976 Pathogenic MSH6 P52701 G1138A 1138 G A 0.324 Neutral MSH6 P52701 G1138C 1138 G C 0.942 Pathogenic MSH6 P52701 G1138D 1138 G D 0.998 Pathogenic MSH6 P52701 G1138E 1138 G E 0.982 Pathogenic MSH6 P52701 G1138F 1138 G F 0.98 Pathogenic MSH6 P52701 G1138H 1138 G H 0.984 Pathogenic MSH6 P52701 G1138I 1138 G I 0.972 Pathogenic MSH6 P52701 G1138K 1138 G K 0.984 Pathogenic MSH6 P52701 G1138L 1138 G L 0.982 Pathogenic MSH6 P52701 G1138M 1138 G M 0.994 Pathogenic MSH6 P52701 G1138N 1138 G N 0.986 Pathogenic MSH6 P52701 G1138P 1138 G P 0.962 Pathogenic MSH6 P52701 G1138Q 1138 G Q 0.99 Pathogenic MSH6 P52701 G1138R 1138 G R 1 Pathogenic MSH6 P52701 G1138S 1138 G S 0.866 Pathogenic MSH6 P52701 G1138T 1138 G T 0.848 Pathogenic MSH6 P52701 G1138V 1138 G V 0.984 Pathogenic MSH6 P52701 G1138W 1138 G W 0.976 Pathogenic MSH6 P52701 G1138Y 1138 G Y 0.956 Pathogenic MSH6 P52701 G1139A 1139 G A 0.768 Pathogenic MSH6 P52701 G1139C 1139 G C 0.948 Pathogenic MSH6 P52701 G1139D 1139 G D 1 Pathogenic MSH6 P52701 G1139E 1139 G E 0.988 Pathogenic MSH6 P52701 G1139F 1139 G F 0.982 Pathogenic MSH6 P52701 G1139H 1139 G H 0.986 Pathogenic MSH6 P52701 G1139I 1139 G I 0.972 Pathogenic MSH6 P52701 G1139K 1139 G K 0.986 Pathogenic MSH6 P52701 G1139L 1139 G L 0.982 Pathogenic MSH6 P52701 G1139M 1139 G M 0.994 Pathogenic MSH6 P52701 G1139N 1139 G N 0.986 Pathogenic MSH6 P52701 G1139P 1139 G P 0.964 Pathogenic MSH6 P52701 G1139Q 1139 G Q 0.994 Pathogenic MSH6 P52701 G1139R 1139 G R 1 Pathogenic MSH6 P52701 G1139S 1139 G S 0.826 Pathogenic MSH6 P52701 G1139T 1139 G T 0.84 Pathogenic MSH6 P52701 G1139V 1139 G V 0.984 Pathogenic MSH6 P52701 G1139W 1139 G W 0.978 Pathogenic MSH6 P52701 G1139Y 1139 G Y 0.958 Pathogenic MSH6 P52701 P114A 114 P A 0.252 Neutral MSH6 P52701 P114C 114 P C 0.21 Neutral MSH6 P52701 P114D 114 P D 0.132 Neutral MSH6 P52701 P114E 114 P E 0.364 Neutral MSH6 P52701 P114F 114 P F 0.518 Pathogenic MSH6 P52701 P114G 114 P G 0.136 Neutral MSH6 P52701 P114H 114 P H 0.48 Neutral MSH6 P52701 P114I 114 P I 0.212 Neutral MSH6 P52701 P114K 114 P K 0.358 Neutral MSH6 P52701 P114L 114 P L 0.172 Neutral MSH6 P52701 P114M 114 P M 0.382 Neutral MSH6 P52701 P114N 114 P N 0.104 Neutral MSH6 P52701 P114Q 114 P Q 0.368 Neutral MSH6 P52701 P114R 114 P R 0.534 Pathogenic MSH6 P52701 P114S 114 P S 0.164 Neutral MSH6 P52701 P114T 114 P T 0.186 Neutral MSH6 P52701 P114V 114 P V 0.214 Neutral MSH6 P52701 P114W 114 P W 0.61 Pathogenic MSH6 P52701 P114Y 114 P Y 0.54 Pathogenic MSH6 P52701 K1140A 1140 K A 0.702 Pathogenic MSH6 P52701 K1140C 1140 K C 0.604 Pathogenic MSH6 P52701 K1140D 1140 K D 0.774 Pathogenic MSH6 P52701 K1140E 1140 K E 0.876 Pathogenic MSH6 P52701 K1140F 1140 K F 0.96 Pathogenic MSH6 P52701 K1140G 1140 K G 0.528 Pathogenic MSH6 P52701 K1140H 1140 K H 0.882 Pathogenic MSH6 P52701 K1140I 1140 K I 0.994 Pathogenic MSH6 P52701 K1140L 1140 K L 0.986 Pathogenic MSH6 P52701 K1140M 1140 K M 0.888 Pathogenic MSH6 P52701 K1140N 1140 K N 0.79 Pathogenic MSH6 P52701 K1140P 1140 K P 0.928 Pathogenic MSH6 P52701 K1140Q 1140 K Q 0.858 Pathogenic MSH6 P52701 K1140R 1140 K R 0.866 Pathogenic MSH6 P52701 K1140S 1140 K S 0.434 Neutral MSH6 P52701 K1140T 1140 K T 0.658 Pathogenic MSH6 P52701 K1140V 1140 K V 0.862 Pathogenic MSH6 P52701 K1140W 1140 K W 0.986 Pathogenic MSH6 P52701 K1140Y 1140 K Y 0.976 Pathogenic MSH6 P52701 S1141A 1141 S A 0.872 Pathogenic MSH6 P52701 S1141C 1141 S C 0.906 Pathogenic MSH6 P52701 S1141D 1141 S D 0.914 Pathogenic MSH6 P52701 S1141E 1141 S E 0.964 Pathogenic MSH6 P52701 S1141F 1141 S F 0.982 Pathogenic MSH6 P52701 S1141G 1141 S G 0.698 Pathogenic MSH6 P52701 S1141H 1141 S H 0.974 Pathogenic MSH6 P52701 S1141I 1141 S I 0.886 Pathogenic MSH6 P52701 S1141K 1141 S K 0.954 Pathogenic MSH6 P52701 S1141L 1141 S L 0.812 Pathogenic MSH6 P52701 S1141M 1141 S M 0.998 Pathogenic MSH6 P52701 S1141N 1141 S N 0.892 Pathogenic MSH6 P52701 S1141P 1141 S P 0.97 Pathogenic MSH6 P52701 S1141Q 1141 S Q 0.952 Pathogenic MSH6 P52701 S1141R 1141 S R 0.974 Pathogenic MSH6 P52701 S1141T 1141 S T 0.754 Pathogenic MSH6 P52701 S1141V 1141 S V 0.954 Pathogenic MSH6 P52701 S1141W 1141 S W 0.954 Pathogenic MSH6 P52701 S1141Y 1141 S Y 0.962 Pathogenic MSH6 P52701 T1142A 1142 T A 0.718 Pathogenic MSH6 P52701 T1142C 1142 T C 0.942 Pathogenic MSH6 P52701 T1142D 1142 T D 0.954 Pathogenic MSH6 P52701 T1142E 1142 T E 0.952 Pathogenic MSH6 P52701 T1142F 1142 T F 0.95 Pathogenic MSH6 P52701 T1142G 1142 T G 0.746 Pathogenic MSH6 P52701 T1142H 1142 T H 0.926 Pathogenic MSH6 P52701 T1142I 1142 T I 0.952 Pathogenic MSH6 P52701 T1142K 1142 T K 0.94 Pathogenic MSH6 P52701 T1142L 1142 T L 0.952 Pathogenic MSH6 P52701 T1142M 1142 T M 0.984 Pathogenic MSH6 P52701 T1142N 1142 T N 0.898 Pathogenic MSH6 P52701 T1142P 1142 T P 0.968 Pathogenic MSH6 P52701 T1142Q 1142 T Q 0.894 Pathogenic MSH6 P52701 T1142R 1142 T R 0.806 Pathogenic MSH6 P52701 T1142S 1142 T S 0.83 Pathogenic MSH6 P52701 T1142V 1142 T V 0.846 Pathogenic MSH6 P52701 T1142W 1142 T W 0.976 Pathogenic MSH6 P52701 T1142Y 1142 T Y 0.976 Pathogenic MSH6 P52701 L1143A 1143 L A 0.63 Pathogenic MSH6 P52701 L1143C 1143 L C 0.756 Pathogenic MSH6 P52701 L1143D 1143 L D 0.884 Pathogenic MSH6 P52701 L1143E 1143 L E 0.864 Pathogenic MSH6 P52701 L1143F 1143 L F 0.556 Pathogenic MSH6 P52701 L1143G 1143 L G 0.796 Pathogenic MSH6 P52701 L1143H 1143 L H 0.874 Pathogenic MSH6 P52701 L1143I 1143 L I 0.192 Neutral MSH6 P52701 L1143K 1143 L K 0.75 Pathogenic MSH6 P52701 L1143M 1143 L M 0.468 Neutral MSH6 P52701 L1143N 1143 L N 0.748 Pathogenic MSH6 P52701 L1143P 1143 L P 0.99 Pathogenic MSH6 P52701 L1143Q 1143 L Q 0.682 Pathogenic MSH6 P52701 L1143R 1143 L R 0.984 Pathogenic MSH6 P52701 L1143S 1143 L S 0.628 Pathogenic MSH6 P52701 L1143T 1143 L T 0.602 Pathogenic MSH6 P52701 L1143V 1143 L V 0.074 Neutral MSH6 P52701 L1143W 1143 L W 0.944 Pathogenic MSH6 P52701 L1143Y 1143 L Y 0.904 Pathogenic MSH6 P52701 M1144A 1144 M A 0.604 Pathogenic MSH6 P52701 M1144C 1144 M C 0.522 Pathogenic MSH6 P52701 M1144D 1144 M D 0.838 Pathogenic MSH6 P52701 M1144E 1144 M E 0.762 Pathogenic MSH6 P52701 M1144F 1144 M F 0.85 Pathogenic MSH6 P52701 M1144G 1144 M G 0.514 Pathogenic MSH6 P52701 M1144H 1144 M H 0.874 Pathogenic MSH6 P52701 M1144I 1144 M I 0.292 Neutral MSH6 P52701 M1144K 1144 M K 0.92 Pathogenic MSH6 P52701 M1144L 1144 M L 0.202 Neutral MSH6 P52701 M1144N 1144 M N 0.87 Pathogenic MSH6 P52701 M1144P 1144 M P 0.916 Pathogenic MSH6 P52701 M1144Q 1144 M Q 0.722 Pathogenic MSH6 P52701 M1144R 1144 M R 0.94 Pathogenic MSH6 P52701 M1144S 1144 M S 0.85 Pathogenic MSH6 P52701 M1144T 1144 M T 0.718 Pathogenic MSH6 P52701 M1144V 1144 M V 0.64 Pathogenic MSH6 P52701 M1144W 1144 M W 0.986 Pathogenic MSH6 P52701 M1144Y 1144 M Y 0.962 Pathogenic MSH6 P52701 R1145A 1145 R A 0.57 Pathogenic MSH6 P52701 R1145C 1145 R C 0.946 Pathogenic MSH6 P52701 R1145D 1145 R D 0.698 Pathogenic MSH6 P52701 R1145E 1145 R E 0.796 Pathogenic MSH6 P52701 R1145F 1145 R F 0.976 Pathogenic MSH6 P52701 R1145G 1145 R G 0.378 Neutral MSH6 P52701 R1145H 1145 R H 0.414 Neutral MSH6 P52701 R1145I 1145 R I 0.978 Pathogenic MSH6 P52701 R1145K 1145 R K 0.772 Pathogenic MSH6 P52701 R1145L 1145 R L 0.988 Pathogenic MSH6 P52701 R1145M 1145 R M 0.788 Pathogenic MSH6 P52701 R1145N 1145 R N 0.648 Pathogenic MSH6 P52701 R1145P 1145 R P 0.986 Pathogenic MSH6 P52701 R1145Q 1145 R Q 0.508 Pathogenic MSH6 P52701 R1145S 1145 R S 0.9 Pathogenic MSH6 P52701 R1145T 1145 R T 0.936 Pathogenic MSH6 P52701 R1145V 1145 R V 0.976 Pathogenic MSH6 P52701 R1145W 1145 R W 0.958 Pathogenic MSH6 P52701 R1145Y 1145 R Y 0.966 Pathogenic MSH6 P52701 Q1146A 1146 Q A 0.78 Pathogenic MSH6 P52701 Q1146C 1146 Q C 0.76 Pathogenic MSH6 P52701 Q1146D 1146 Q D 0.858 Pathogenic MSH6 P52701 Q1146E 1146 Q E 0.246 Neutral MSH6 P52701 Q1146F 1146 Q F 0.93 Pathogenic MSH6 P52701 Q1146G 1146 Q G 0.57 Pathogenic MSH6 P52701 Q1146H 1146 Q H 0.988 Pathogenic MSH6 P52701 Q1146I 1146 Q I 0.95 Pathogenic MSH6 P52701 Q1146K 1146 Q K 0.972 Pathogenic MSH6 P52701 Q1146L 1146 Q L 0.888 Pathogenic MSH6 P52701 Q1146M 1146 Q M 0.28 Neutral MSH6 P52701 Q1146N 1146 Q N 0.89 Pathogenic MSH6 P52701 Q1146P 1146 Q P 0.916 Pathogenic MSH6 P52701 Q1146R 1146 Q R 0.924 Pathogenic MSH6 P52701 Q1146S 1146 Q S 0.838 Pathogenic MSH6 P52701 Q1146T 1146 Q T 0.654 Pathogenic MSH6 P52701 Q1146V 1146 Q V 0.92 Pathogenic MSH6 P52701 Q1146W 1146 Q W 0.962 Pathogenic MSH6 P52701 Q1146Y 1146 Q Y 0.95 Pathogenic MSH6 P52701 A1147C 1147 A C 0.19 Neutral MSH6 P52701 A1147D 1147 A D 0.86 Pathogenic MSH6 P52701 A1147E 1147 A E 0.882 Pathogenic MSH6 P52701 A1147F 1147 A F 0.97 Pathogenic MSH6 P52701 A1147G 1147 A G 0.51 Pathogenic MSH6 P52701 A1147H 1147 A H 0.872 Pathogenic MSH6 P52701 A1147I 1147 A I 0.684 Pathogenic MSH6 P52701 A1147K 1147 A K 0.914 Pathogenic MSH6 P52701 A1147L 1147 A L 0.586 Pathogenic MSH6 P52701 A1147M 1147 A M 0.6 Pathogenic MSH6 P52701 A1147N 1147 A N 0.646 Pathogenic MSH6 P52701 A1147P 1147 A P 0.918 Pathogenic MSH6 P52701 A1147Q 1147 A Q 0.792 Pathogenic MSH6 P52701 A1147R 1147 A R 0.926 Pathogenic MSH6 P52701 A1147S 1147 A S 0.014 Neutral MSH6 P52701 A1147T 1147 A T 0.056 Neutral MSH6 P52701 A1147V 1147 A V 0.138 Neutral MSH6 P52701 A1147W 1147 A W 0.958 Pathogenic MSH6 P52701 A1147Y 1147 A Y 0.944 Pathogenic MSH6 P52701 G1148A 1148 G A 0.062 Neutral MSH6 P52701 G1148C 1148 G C 0.656 Pathogenic MSH6 P52701 G1148D 1148 G D 0.684 Pathogenic MSH6 P52701 G1148E 1148 G E 0.854 Pathogenic MSH6 P52701 G1148F 1148 G F 0.924 Pathogenic MSH6 P52701 G1148H 1148 G H 0.92 Pathogenic MSH6 P52701 G1148I 1148 G I 0.89 Pathogenic MSH6 P52701 G1148K 1148 G K 0.922 Pathogenic MSH6 P52701 G1148L 1148 G L 0.888 Pathogenic MSH6 P52701 G1148M 1148 G M 0.922 Pathogenic MSH6 P52701 G1148N 1148 G N 0.586 Pathogenic MSH6 P52701 G1148P 1148 G P 0.856 Pathogenic MSH6 P52701 G1148Q 1148 G Q 0.738 Pathogenic MSH6 P52701 G1148R 1148 G R 0.882 Pathogenic MSH6 P52701 G1148S 1148 G S 0.342 Neutral MSH6 P52701 G1148T 1148 G T 0.768 Pathogenic MSH6 P52701 G1148V 1148 G V 0.892 Pathogenic MSH6 P52701 G1148W 1148 G W 0.92 Pathogenic MSH6 P52701 G1148Y 1148 G Y 0.912 Pathogenic MSH6 P52701 L1149A 1149 L A 0.562 Pathogenic MSH6 P52701 L1149C 1149 L C 0.272 Neutral MSH6 P52701 L1149D 1149 L D 0.912 Pathogenic MSH6 P52701 L1149E 1149 L E 0.89 Pathogenic MSH6 P52701 L1149F 1149 L F 0.938 Pathogenic MSH6 P52701 L1149G 1149 L G 0.81 Pathogenic MSH6 P52701 L1149H 1149 L H 0.784 Pathogenic MSH6 P52701 L1149I 1149 L I 0.138 Neutral MSH6 P52701 L1149K 1149 L K 0.726 Pathogenic MSH6 P52701 L1149M 1149 L M 0.246 Neutral MSH6 P52701 L1149N 1149 L N 0.782 Pathogenic MSH6 P52701 L1149P 1149 L P 0.98 Pathogenic MSH6 P52701 L1149Q 1149 L Q 0.612 Pathogenic MSH6 P52701 L1149R 1149 L R 0.996 Pathogenic MSH6 P52701 L1149S 1149 L S 0.602 Pathogenic MSH6 P52701 L1149T 1149 L T 0.12 Neutral MSH6 P52701 L1149V 1149 L V 0.094 Neutral MSH6 P52701 L1149W 1149 L W 0.908 Pathogenic MSH6 P52701 L1149Y 1149 L Y 0.868 Pathogenic MSH6 P52701 F115A 115 F A 0.122 Neutral MSH6 P52701 F115C 115 F C 0.088 Neutral MSH6 P52701 F115D 115 F D 0.162 Neutral MSH6 P52701 F115E 115 F E 0.184 Neutral MSH6 P52701 F115G 115 F G 0.136 Neutral MSH6 P52701 F115H 115 F H 0.072 Neutral MSH6 P52701 F115I 115 F I 0.054 Neutral MSH6 P52701 F115K 115 F K 0.042 Neutral MSH6 P52701 F115L 115 F L 0.004 Neutral MSH6 P52701 F115M 115 F M 0.086 Neutral MSH6 P52701 F115N 115 F N 0.174 Neutral MSH6 P52701 F115P 115 F P 0.178 Neutral MSH6 P52701 F115Q 115 F Q 0.164 Neutral MSH6 P52701 F115R 115 F R 0.142 Neutral MSH6 P52701 F115S 115 F S 0.156 Neutral MSH6 P52701 F115T 115 F T 0.012 Neutral MSH6 P52701 F115V 115 F V 0.012 Neutral MSH6 P52701 F115W 115 F W 0.268 Neutral MSH6 P52701 F115Y 115 F Y 0.1 Neutral MSH6 P52701 L1150A 1150 L A 0.038 Neutral MSH6 P52701 L1150C 1150 L C 0.166 Neutral MSH6 P52701 L1150D 1150 L D 0.676 Pathogenic MSH6 P52701 L1150E 1150 L E 0.63 Pathogenic MSH6 P52701 L1150F 1150 L F 0.734 Pathogenic MSH6 P52701 L1150G 1150 L G 0.168 Neutral MSH6 P52701 L1150H 1150 L H 0.424 Neutral MSH6 P52701 L1150I 1150 L I 0.034 Neutral MSH6 P52701 L1150K 1150 L K 0.484 Neutral MSH6 P52701 L1150M 1150 L M 0.468 Neutral MSH6 P52701 L1150N 1150 L N 0.622 Pathogenic MSH6 P52701 L1150P 1150 L P 0.954 Pathogenic MSH6 P52701 L1150Q 1150 L Q 0.088 Neutral MSH6 P52701 L1150R 1150 L R 0.872 Pathogenic MSH6 P52701 L1150S 1150 L S 0.072 Neutral MSH6 P52701 L1150T 1150 L T 0.04 Neutral MSH6 P52701 L1150V 1150 L V 0.002 Neutral MSH6 P52701 L1150W 1150 L W 0.848 Pathogenic MSH6 P52701 L1150Y 1150 L Y 0.84 Pathogenic MSH6 P52701 A1151C 1151 A C 0.398 Neutral MSH6 P52701 A1151D 1151 A D 0.824 Pathogenic MSH6 P52701 A1151E 1151 A E 0.864 Pathogenic MSH6 P52701 A1151F 1151 A F 0.928 Pathogenic MSH6 P52701 A1151G 1151 A G 0.642 Pathogenic MSH6 P52701 A1151H 1151 A H 0.822 Pathogenic MSH6 P52701 A1151I 1151 A I 0.718 Pathogenic MSH6 P52701 A1151K 1151 A K 0.884 Pathogenic MSH6 P52701 A1151L 1151 A L 0.9 Pathogenic MSH6 P52701 A1151M 1151 A M 0.704 Pathogenic MSH6 P52701 A1151N 1151 A N 0.804 Pathogenic MSH6 P52701 A1151P 1151 A P 0.906 Pathogenic MSH6 P52701 A1151Q 1151 A Q 0.84 Pathogenic MSH6 P52701 A1151R 1151 A R 0.88 Pathogenic MSH6 P52701 A1151S 1151 A S 0.19 Neutral MSH6 P52701 A1151T 1151 A T 0.18 Neutral MSH6 P52701 A1151V 1151 A V 0.534 Pathogenic MSH6 P52701 A1151W 1151 A W 0.928 Pathogenic MSH6 P52701 A1151Y 1151 A Y 0.892 Pathogenic MSH6 P52701 V1152A 1152 V A 0.394 Neutral MSH6 P52701 V1152C 1152 V C 0.772 Pathogenic MSH6 P52701 V1152D 1152 V D 0.848 Pathogenic MSH6 P52701 V1152E 1152 V E 0.964 Pathogenic MSH6 P52701 V1152F 1152 V F 0.906 Pathogenic MSH6 P52701 V1152G 1152 V G 0.894 Pathogenic MSH6 P52701 V1152H 1152 V H 0.866 Pathogenic MSH6 P52701 V1152I 1152 V I 0.184 Neutral MSH6 P52701 V1152K 1152 V K 0.988 Pathogenic MSH6 P52701 V1152L 1152 V L 0.282 Neutral MSH6 P52701 V1152M 1152 V M 0.872 Pathogenic MSH6 P52701 V1152N 1152 V N 0.914 Pathogenic MSH6 P52701 V1152P 1152 V P 0.982 Pathogenic MSH6 P52701 V1152Q 1152 V Q 0.972 Pathogenic MSH6 P52701 V1152R 1152 V R 0.948 Pathogenic MSH6 P52701 V1152S 1152 V S 0.774 Pathogenic MSH6 P52701 V1152T 1152 V T 0.832 Pathogenic MSH6 P52701 V1152W 1152 V W 0.93 Pathogenic MSH6 P52701 V1152Y 1152 V Y 0.956 Pathogenic MSH6 P52701 M1153A 1153 M A 0.606 Pathogenic MSH6 P52701 M1153C 1153 M C 0.522 Pathogenic MSH6 P52701 M1153D 1153 M D 0.852 Pathogenic MSH6 P52701 M1153E 1153 M E 0.768 Pathogenic MSH6 P52701 M1153F 1153 M F 0.864 Pathogenic MSH6 P52701 M1153G 1153 M G 0.52 Pathogenic MSH6 P52701 M1153H 1153 M H 0.88 Pathogenic MSH6 P52701 M1153I 1153 M I 0.296 Neutral MSH6 P52701 M1153K 1153 M K 0.928 Pathogenic MSH6 P52701 M1153L 1153 M L 0.202 Neutral MSH6 P52701 M1153N 1153 M N 0.89 Pathogenic MSH6 P52701 M1153P 1153 M P 0.922 Pathogenic MSH6 P52701 M1153Q 1153 M Q 0.732 Pathogenic MSH6 P52701 M1153R 1153 M R 0.954 Pathogenic MSH6 P52701 M1153S 1153 M S 0.86 Pathogenic MSH6 P52701 M1153T 1153 M T 0.728 Pathogenic MSH6 P52701 M1153V 1153 M V 0.65 Pathogenic MSH6 P52701 M1153W 1153 M W 0.994 Pathogenic MSH6 P52701 M1153Y 1153 M Y 0.976 Pathogenic MSH6 P52701 A1154C 1154 A C 0.852 Pathogenic MSH6 P52701 A1154D 1154 A D 0.924 Pathogenic MSH6 P52701 A1154E 1154 A E 0.874 Pathogenic MSH6 P52701 A1154F 1154 A F 0.964 Pathogenic MSH6 P52701 A1154G 1154 A G 0.742 Pathogenic MSH6 P52701 A1154H 1154 A H 0.862 Pathogenic MSH6 P52701 A1154I 1154 A I 0.958 Pathogenic MSH6 P52701 A1154K 1154 A K 0.934 Pathogenic MSH6 P52701 A1154L 1154 A L 0.978 Pathogenic MSH6 P52701 A1154M 1154 A M 0.848 Pathogenic MSH6 P52701 A1154N 1154 A N 0.858 Pathogenic MSH6 P52701 A1154P 1154 A P 0.966 Pathogenic MSH6 P52701 A1154Q 1154 A Q 0.812 Pathogenic MSH6 P52701 A1154R 1154 A R 0.958 Pathogenic MSH6 P52701 A1154S 1154 A S 0.296 Neutral MSH6 P52701 A1154T 1154 A T 0.414 Neutral MSH6 P52701 A1154V 1154 A V 0.906 Pathogenic MSH6 P52701 A1154W 1154 A W 0.974 Pathogenic MSH6 P52701 A1154Y 1154 A Y 0.962 Pathogenic MSH6 P52701 Q1155A 1155 Q A 0.776 Pathogenic MSH6 P52701 Q1155C 1155 Q C 0.75 Pathogenic MSH6 P52701 Q1155D 1155 Q D 0.842 Pathogenic MSH6 P52701 Q1155E 1155 Q E 0.686 Pathogenic MSH6 P52701 Q1155F 1155 Q F 0.902 Pathogenic MSH6 P52701 Q1155G 1155 Q G 0.526 Pathogenic MSH6 P52701 Q1155H 1155 Q H 0.292 Neutral MSH6 P52701 Q1155I 1155 Q I 0.932 Pathogenic MSH6 P52701 Q1155K 1155 Q K 0.87 Pathogenic MSH6 P52701 Q1155L 1155 Q L 0.834 Pathogenic MSH6 P52701 Q1155M 1155 Q M 0.87 Pathogenic MSH6 P52701 Q1155N 1155 Q N 0.878 Pathogenic MSH6 P52701 Q1155P 1155 Q P 0.898 Pathogenic MSH6 P52701 Q1155R 1155 Q R 0.916 Pathogenic MSH6 P52701 Q1155S 1155 Q S 0.63 Pathogenic MSH6 P52701 Q1155T 1155 Q T 0.438 Neutral MSH6 P52701 Q1155V 1155 Q V 0.908 Pathogenic MSH6 P52701 Q1155W 1155 Q W 0.938 Pathogenic MSH6 P52701 Q1155Y 1155 Q Y 0.928 Pathogenic MSH6 P52701 M1156A 1156 M A 0.266 Neutral MSH6 P52701 M1156C 1156 M C 0.194 Neutral MSH6 P52701 M1156D 1156 M D 0.572 Pathogenic MSH6 P52701 M1156E 1156 M E 0.324 Neutral MSH6 P52701 M1156F 1156 M F 0.718 Pathogenic MSH6 P52701 M1156G 1156 M G 0.314 Neutral MSH6 P52701 M1156H 1156 M H 0.35 Neutral MSH6 P52701 M1156I 1156 M I 0.06 Neutral MSH6 P52701 M1156K 1156 M K 0.546 Pathogenic MSH6 P52701 M1156L 1156 M L 0.058 Neutral MSH6 P52701 M1156N 1156 M N 0.592 Pathogenic MSH6 P52701 M1156P 1156 M P 0.852 Pathogenic MSH6 P52701 M1156Q 1156 M Q 0.26 Neutral MSH6 P52701 M1156R 1156 M R 0.588 Pathogenic MSH6 P52701 M1156S 1156 M S 0.484 Neutral MSH6 P52701 M1156T 1156 M T 0.446 Neutral MSH6 P52701 M1156V 1156 M V 0.052 Neutral MSH6 P52701 M1156W 1156 M W 0.926 Pathogenic MSH6 P52701 M1156Y 1156 M Y 0.848 Pathogenic MSH6 P52701 G1157A 1157 G A 0.65 Pathogenic MSH6 P52701 G1157C 1157 G C 0.798 Pathogenic MSH6 P52701 G1157D 1157 G D 0.846 Pathogenic MSH6 P52701 G1157E 1157 G E 0.924 Pathogenic MSH6 P52701 G1157F 1157 G F 0.944 Pathogenic MSH6 P52701 G1157H 1157 G H 0.934 Pathogenic MSH6 P52701 G1157I 1157 G I 0.926 Pathogenic MSH6 P52701 G1157K 1157 G K 0.938 Pathogenic MSH6 P52701 G1157L 1157 G L 0.904 Pathogenic MSH6 P52701 G1157M 1157 G M 0.95 Pathogenic MSH6 P52701 G1157N 1157 G N 0.82 Pathogenic MSH6 P52701 G1157P 1157 G P 0.894 Pathogenic MSH6 P52701 G1157Q 1157 G Q 0.86 Pathogenic MSH6 P52701 G1157R 1157 G R 0.958 Pathogenic MSH6 P52701 G1157S 1157 G S 0.654 Pathogenic MSH6 P52701 G1157T 1157 G T 0.798 Pathogenic MSH6 P52701 G1157V 1157 G V 0.9 Pathogenic MSH6 P52701 G1157W 1157 G W 0.93 Pathogenic MSH6 P52701 G1157Y 1157 G Y 0.914 Pathogenic MSH6 P52701 C1158A 1158 C A 0.09 Neutral MSH6 P52701 C1158D 1158 C D 0.87 Pathogenic MSH6 P52701 C1158E 1158 C E 0.872 Pathogenic MSH6 P52701 C1158F 1158 C F 0.994 Pathogenic MSH6 P52701 C1158G 1158 C G 0.18 Neutral MSH6 P52701 C1158H 1158 C H 0.884 Pathogenic MSH6 P52701 C1158I 1158 C I 0.95 Pathogenic MSH6 P52701 C1158K 1158 C K 0.862 Pathogenic MSH6 P52701 C1158L 1158 C L 0.826 Pathogenic MSH6 P52701 C1158M 1158 C M 0.79 Pathogenic MSH6 P52701 C1158N 1158 C N 0.69 Pathogenic MSH6 P52701 C1158P 1158 C P 0.974 Pathogenic MSH6 P52701 C1158Q 1158 C Q 0.74 Pathogenic MSH6 P52701 C1158R 1158 C R 0.984 Pathogenic MSH6 P52701 C1158S 1158 C S 0.09 Neutral MSH6 P52701 C1158T 1158 C T 0.788 Pathogenic MSH6 P52701 C1158V 1158 C V 0.46 Neutral MSH6 P52701 C1158W 1158 C W 0.994 Pathogenic MSH6 P52701 C1158Y 1158 C Y 0.99 Pathogenic MSH6 P52701 Y1159A 1159 Y A 0.222 Neutral MSH6 P52701 Y1159C 1159 Y C 0.26 Neutral MSH6 P52701 Y1159D 1159 Y D 0.1 Neutral MSH6 P52701 Y1159E 1159 Y E 0.286 Neutral MSH6 P52701 Y1159F 1159 Y F 0.024 Neutral MSH6 P52701 Y1159G 1159 Y G 0.254 Neutral MSH6 P52701 Y1159H 1159 Y H 0.026 Neutral MSH6 P52701 Y1159I 1159 Y I 0.468 Neutral MSH6 P52701 Y1159K 1159 Y K 0.124 Neutral MSH6 P52701 Y1159L 1159 Y L 0.06 Neutral MSH6 P52701 Y1159M 1159 Y M 0.084 Neutral MSH6 P52701 Y1159N 1159 Y N 0.13 Neutral MSH6 P52701 Y1159P 1159 Y P 0.262 Neutral MSH6 P52701 Y1159Q 1159 Y Q 0.244 Neutral MSH6 P52701 Y1159R 1159 Y R 0.092 Neutral MSH6 P52701 Y1159S 1159 Y S 0.258 Neutral MSH6 P52701 Y1159T 1159 Y T 0.318 Neutral MSH6 P52701 Y1159V 1159 Y V 0.41 Neutral MSH6 P52701 Y1159W 1159 Y W 0.072 Neutral MSH6 P52701 D116A 116 D A 0.082 Neutral MSH6 P52701 D116C 116 D C 0.148 Neutral MSH6 P52701 D116E 116 D E 0.014 Neutral MSH6 P52701 D116F 116 D F 0.37 Neutral MSH6 P52701 D116G 116 D G 0.14 Neutral MSH6 P52701 D116H 116 D H 0.106 Neutral MSH6 P52701 D116I 116 D I 0.262 Neutral MSH6 P52701 D116K 116 D K 0.176 Neutral MSH6 P52701 D116L 116 D L 0.026 Neutral MSH6 P52701 D116M 116 D M 0.19 Neutral MSH6 P52701 D116N 116 D N 0.02 Neutral MSH6 P52701 D116P 116 D P 0.288 Neutral MSH6 P52701 D116Q 116 D Q 0.112 Neutral MSH6 P52701 D116R 116 D R 0.166 Neutral MSH6 P52701 D116S 116 D S 0.004 Neutral MSH6 P52701 D116T 116 D T 0.02 Neutral MSH6 P52701 D116V 116 D V 0.262 Neutral MSH6 P52701 D116W 116 D W 0.434 Neutral MSH6 P52701 D116Y 116 D Y 0.404 Neutral MSH6 P52701 V1160A 1160 V A 0.484 Neutral MSH6 P52701 V1160C 1160 V C 0.804 Pathogenic MSH6 P52701 V1160D 1160 V D 0.86 Pathogenic MSH6 P52701 V1160E 1160 V E 0.964 Pathogenic MSH6 P52701 V1160F 1160 V F 0.93 Pathogenic MSH6 P52701 V1160G 1160 V G 0.912 Pathogenic MSH6 P52701 V1160H 1160 V H 0.898 Pathogenic MSH6 P52701 V1160I 1160 V I 0.24 Neutral MSH6 P52701 V1160K 1160 V K 0.986 Pathogenic MSH6 P52701 V1160L 1160 V L 0.272 Neutral MSH6 P52701 V1160M 1160 V M 0.908 Pathogenic MSH6 P52701 V1160N 1160 V N 0.922 Pathogenic MSH6 P52701 V1160P 1160 V P 0.986 Pathogenic MSH6 P52701 V1160Q 1160 V Q 0.972 Pathogenic MSH6 P52701 V1160R 1160 V R 0.948 Pathogenic MSH6 P52701 V1160S 1160 V S 0.806 Pathogenic MSH6 P52701 V1160T 1160 V T 0.878 Pathogenic MSH6 P52701 V1160W 1160 V W 0.954 Pathogenic MSH6 P52701 V1160Y 1160 V Y 0.974 Pathogenic MSH6 P52701 P1161A 1161 P A 0.834 Pathogenic MSH6 P52701 P1161C 1161 P C 0.92 Pathogenic MSH6 P52701 P1161D 1161 P D 0.87 Pathogenic MSH6 P52701 P1161E 1161 P E 0.962 Pathogenic MSH6 P52701 P1161F 1161 P F 1 Pathogenic MSH6 P52701 P1161G 1161 P G 0.696 Pathogenic MSH6 P52701 P1161H 1161 P H 0.98 Pathogenic MSH6 P52701 P1161I 1161 P I 0.938 Pathogenic MSH6 P52701 P1161K 1161 P K 0.952 Pathogenic MSH6 P52701 P1161L 1161 P L 0.998 Pathogenic MSH6 P52701 P1161M 1161 P M 0.962 Pathogenic MSH6 P52701 P1161N 1161 P N 0.79 Pathogenic MSH6 P52701 P1161Q 1161 P Q 0.884 Pathogenic MSH6 P52701 P1161R 1161 P R 0.988 Pathogenic MSH6 P52701 P1161S 1161 P S 0.342 Neutral MSH6 P52701 P1161T 1161 P T 0.746 Pathogenic MSH6 P52701 P1161V 1161 P V 0.85 Pathogenic MSH6 P52701 P1161W 1161 P W 0.936 Pathogenic MSH6 P52701 P1161Y 1161 P Y 0.93 Pathogenic MSH6 P52701 A1162C 1162 A C 0.336 Neutral MSH6 P52701 A1162D 1162 A D 0.918 Pathogenic MSH6 P52701 A1162E 1162 A E 0.888 Pathogenic MSH6 P52701 A1162F 1162 A F 0.962 Pathogenic MSH6 P52701 A1162G 1162 A G 0.752 Pathogenic MSH6 P52701 A1162H 1162 A H 0.87 Pathogenic MSH6 P52701 A1162I 1162 A I 0.954 Pathogenic MSH6 P52701 A1162K 1162 A K 0.934 Pathogenic MSH6 P52701 A1162L 1162 A L 0.976 Pathogenic MSH6 P52701 A1162M 1162 A M 0.852 Pathogenic MSH6 P52701 A1162N 1162 A N 0.846 Pathogenic MSH6 P52701 A1162P 1162 A P 0.968 Pathogenic MSH6 P52701 A1162Q 1162 A Q 0.824 Pathogenic MSH6 P52701 A1162R 1162 A R 0.96 Pathogenic MSH6 P52701 A1162S 1162 A S 0.218 Neutral MSH6 P52701 A1162T 1162 A T 0.74 Pathogenic MSH6 P52701 A1162V 1162 A V 0.912 Pathogenic MSH6 P52701 A1162W 1162 A W 0.972 Pathogenic MSH6 P52701 A1162Y 1162 A Y 0.958 Pathogenic MSH6 P52701 E1163A 1163 E A 0.236 Neutral MSH6 P52701 E1163C 1163 E C 0.462 Neutral MSH6 P52701 E1163D 1163 E D 0.056 Neutral MSH6 P52701 E1163F 1163 E F 0.274 Neutral MSH6 P52701 E1163G 1163 E G 0.218 Neutral MSH6 P52701 E1163H 1163 E H 0.59 Pathogenic MSH6 P52701 E1163I 1163 E I 0.904 Pathogenic MSH6 P52701 E1163K 1163 E K 0.052 Neutral MSH6 P52701 E1163L 1163 E L 0.282 Neutral MSH6 P52701 E1163M 1163 E M 0.68 Pathogenic MSH6 P52701 E1163N 1163 E N 0.172 Neutral MSH6 P52701 E1163P 1163 E P 0.866 Pathogenic MSH6 P52701 E1163Q 1163 E Q 0.032 Neutral MSH6 P52701 E1163R 1163 E R 0.156 Neutral MSH6 P52701 E1163S 1163 E S 0.054 Neutral MSH6 P52701 E1163T 1163 E T 0.056 Neutral MSH6 P52701 E1163V 1163 E V 0.098 Neutral 2 MSH6 P52701 E1163W 1163 E W 0.968 Pathogenic MSH6 P52701 E1163Y 1163 E Y 0.906 Pathogenic MSH6 P52701 V1164A 1164 V A 0.018 Neutral MSH6 P52701 V1164C 1164 V C 0.126 Neutral MSH6 P52701 V1164D 1164 V D 0.19 Neutral MSH6 P52701 V1164E 1164 V E 0.114 Neutral MSH6 P52701 V1164F 1164 V F 0.48 Neutral MSH6 P52701 V1164G 1164 V G 0.084 Neutral MSH6 P52701 V1164H 1164 V H 0.188 Neutral MSH6 P52701 V1164I 1164 V I 0.388 Neutral MSH6 P52701 V1164K 1164 V K 0.17 Neutral MSH6 P52701 V1164L 1164 V L 0.248 Neutral MSH6 P52701 V1164M 1164 V M 0.446 Neutral MSH6 P52701 V1164N 1164 V N 0.08 Neutral MSH6 P52701 V1164P 1164 V P 0.826 Pathogenic MSH6 P52701 V1164Q 1164 V Q 0.262 Neutral MSH6 P52701 V1164R 1164 V R 0.518 Pathogenic MSH6 P52701 V1164S 1164 V S 0.094 Neutral MSH6 P52701 V1164T 1164 V T 0.028 Neutral MSH6 P52701 V1164W 1164 V W 0.816 Pathogenic MSH6 P52701 V1164Y 1164 V Y 0.48 Neutral MSH6 P52701 C1165A 1165 C A 0.05 Neutral MSH6 P52701 C1165D 1165 C D 0.602 Pathogenic MSH6 P52701 C1165E 1165 C E 0.582 Pathogenic MSH6 P52701 C1165F 1165 C F 0.578 Pathogenic MSH6 P52701 C1165G 1165 C G 0.502 Pathogenic MSH6 P52701 C1165H 1165 C H 0.714 Pathogenic MSH6 P52701 C1165I 1165 C I 0.784 Pathogenic MSH6 P52701 C1165K 1165 C K 0.642 Pathogenic MSH6 P52701 C1165L 1165 C L 0.1 Neutral MSH6 P52701 C1165M 1165 C M 0.09 Neutral MSH6 P52701 C1165N 1165 C N 0.38 Neutral MSH6 P52701 C1165P 1165 C P 0.858 Pathogenic MSH6 P52701 C1165Q 1165 C Q 0.492 Neutral MSH6 P52701 C1165R 1165 C R 0.914 Pathogenic MSH6 P52701 C1165S 1165 C S 0.416 Neutral MSH6 P52701 C1165T 1165 C T 0.512 Pathogenic MSH6 P52701 C1165V 1165 C V 0.67 Pathogenic MSH6 P52701 C1165W 1165 C W 0.934 Pathogenic MSH6 P52701 C1165Y 1165 C Y 0.932 Pathogenic MSH6 P52701 R1166A 1166 R A 0.14 Neutral MSH6 P52701 R1166C 1166 R C 0.072 Neutral MSH6 P52701 R1166D 1166 R D 0.058 Neutral MSH6 P52701 R1166E 1166 R E 0.062 Neutral MSH6 P52701 R1166F 1166 R F 0.938 Pathogenic MSH6 P52701 R1166G 1166 R G 0.142 Neutral MSH6 P52701 R1166H 1166 R H 0.174 Neutral MSH6 P52701 R1166I 1166 R I 0.768 Pathogenic MSH6 P52701 R1166K 1166 R K 0.036 Neutral MSH6 P52701 R1166L 1166 R L 0.362 Neutral MSH6 P52701 R1166M 1166 R M 0.672 Pathogenic MSH6 P52701 R1166N 1166 R N 0.14 Neutral MSH6 P52701 R1166P 1166 R P 0.848 Pathogenic MSH6 P52701 R1166Q 1166 R Q 0.178 Neutral MSH6 P52701 R1166S 1166 R S 0.048 Neutral MSH6 P52701 R1166T 1166 R T 0.062 Neutral MSH6 P52701 R1166V 1166 R V 0.226 Neutral MSH6 P52701 R1166W 1166 R W 0.914 Pathogenic MSH6 P52701 R1166Y 1166 R Y 0.894 Pathogenic MSH6 P52701 L1167A 1167 L A 0.698 Pathogenic MSH6 P52701 L1167C 1167 L C 0.816 Pathogenic MSH6 P52701 L1167D 1167 L D 0.898 Pathogenic MSH6 P52701 L1167E 1167 L E 0.878 Pathogenic MSH6 P52701 L1167F 1167 L F 0.456 Neutral MSH6 P52701 L1167G 1167 L G 0.814 Pathogenic MSH6 P52701 L1167H 1167 L H 0.906 Pathogenic MSH6 P52701 L1167I 1167 L I 0.266 Neutral MSH6 P52701 L1167K 1167 L K 0.754 Pathogenic MSH6 P52701 L1167M 1167 L M 0.156 Neutral MSH6 P52701 L1167N 1167 L N 0.768 Pathogenic MSH6 P52701 L1167P 1167 L P 0.992 Pathogenic MSH6 P52701 L1167Q 1167 L Q 0.734 Pathogenic MSH6 P52701 L1167R 1167 L R 0.984 Pathogenic MSH6 P52701 L1167S 1167 L S 0.644 Pathogenic MSH6 P52701 L1167T 1167 L T 0.61 Pathogenic MSH6 P52701 L1167V 1167 L V 0.14 Neutral MSH6 P52701 L1167W 1167 L W 0.93 Pathogenic MSH6 P52701 L1167Y 1167 L Y 0.896 Pathogenic MSH6 P52701 T1168A 1168 T A 0.274 Neutral MSH6 P52701 T1168C 1168 T C 0.842 Pathogenic MSH6 P52701 T1168D 1168 T D 0.848 Pathogenic MSH6 P52701 T1168E 1168 T E 0.912 Pathogenic MSH6 P52701 T1168F 1168 T F 0.926 Pathogenic MSH6 P52701 T1168G 1168 T G 0.588 Pathogenic MSH6 P52701 T1168H 1168 T H 0.862 Pathogenic MSH6 P52701 T1168I 1168 T I 0.608 Pathogenic MSH6 P52701 T1168K 1168 T K 0.874 Pathogenic MSH6 P52701 T1168L 1168 T L 0.6 Pathogenic MSH6 P52701 T1168M 1168 T M 0.742 Pathogenic MSH6 P52701 T1168N 1168 T N 0.19 Neutral MSH6 P52701 T1168P 1168 T P 0.914 Pathogenic MSH6 P52701 T1168Q 1168 T Q 0.784 Pathogenic MSH6 P52701 T1168R 1168 T R 0.714 Pathogenic MSH6 P52701 T1168S 1168 T S 0.064 Neutral MSH6 P52701 T1168V 1168 T V 0.886 Pathogenic MSH6 P52701 T1168W 1168 T W 0.994 Pathogenic MSH6 P52701 T1168Y 1168 T Y 0.994 Pathogenic MSH6 P52701 P1169A 1169 P A 0.824 Pathogenic MSH6 P52701 P1169C 1169 P C 0.914 Pathogenic MSH6 P52701 P1169D 1169 P D 0.86 Pathogenic MSH6 P52701 P1169E 1169 P E 0.958 Pathogenic MSH6 P52701 P1169F 1169 P F 0.996 Pathogenic MSH6 P52701 P1169G 1169 P G 0.65 Pathogenic MSH6 P52701 P1169H 1169 P H 0.978 Pathogenic MSH6 P52701 P1169I 1169 P I 0.368 Neutral MSH6 P52701 P1169K 1169 P K 0.952 Pathogenic MSH6 P52701 P1169L 1169 P L 0.274 Neutral MSH6 P52701 P1169M 1169 P M 0.956 Pathogenic MSH6 P52701 P1169N 1169 P N 0.752 Pathogenic MSH6 P52701 P1169Q 1169 P Q 0.848 Pathogenic MSH6 P52701 P1169R 1169 P R 0.98 Pathogenic MSH6 P52701 P1169S 1169 P S 0.35 Neutral MSH6 P52701 P1169T 1169 P T 0.718 Pathogenic MSH6 P52701 P1169V 1169 P V 0.176 Neutral MSH6 P52701 P1169W 1169 P W 0.94 Pathogenic MSH6 P52701 P1169Y 1169 P Y 0.938 Pathogenic MSH6 P52701 G117A 117 G A 0.07 Neutral MSH6 P52701 G117C 117 G C 0.2 Neutral MSH6 P52701 G117D 117 G D 0.142 Neutral MSH6 P52701 G117E 117 G E 0.214 Neutral MSH6 P52701 G117F 117 G F 0.576 Pathogenic MSH6 P52701 G117H 117 G H 0.522 Pathogenic MSH6 P52701 G117I 117 G I 0.49 Neutral MSH6 P52701 G117K 117 G K 0.44 Neutral MSH6 P52701 G117L 117 G L 0.496 Neutral MSH6 P52701 G117M 117 G M 0.51 Pathogenic MSH6 P52701 G117N 117 G N 0.202 Neutral MSH6 P52701 G117P 117 G P 0.446 Neutral MSH6 P52701 G117Q 117 G Q 0.326 Neutral MSH6 P52701 G117R 117 G R 0.378 Neutral MSH6 P52701 G117S 117 G S 0.198 Neutral MSH6 P52701 G117T 117 G T 0.334 Neutral MSH6 P52701 G117V 117 G V 0.466 Neutral MSH6 P52701 G117W 117 G W 0.574 Pathogenic MSH6 P52701 G117Y 117 G Y 0.57 Pathogenic MSH6 P52701 I1170A 1170 I A 0.202 Neutral MSH6 P52701 I1170C 1170 I C 0.126 Neutral MSH6 P52701 I1170D 1170 I D 0.76 Pathogenic MSH6 P52701 I1170E 1170 I E 0.764 Pathogenic MSH6 P52701 I1170F 1170 I F 0.324 Neutral MSH6 P52701 I1170G 1170 I G 0.808 Pathogenic MSH6 P52701 I1170H 1170 I H 0.84 Pathogenic MSH6 P52701 I1170K 1170 I K 0.852 Pathogenic MSH6 P52701 I1170L 1170 I L 0.184 Neutral MSH6 P52701 I1170M 1170 I M 0.168 Neutral MSH6 P52701 I1170N 1170 I N 0.786 Pathogenic MSH6 P52701 I1170P 1170 I P 0.944 Pathogenic MSH6 P52701 I1170Q 1170 I Q 0.796 Pathogenic MSH6 P52701 I1170R 1170 I R 0.88 Pathogenic MSH6 P52701 I1170S 1170 I S 0.626 Pathogenic MSH6 P52701 I1170T 1170 I T 0.108 Neutral MSH6 P52701 I1170V 1170 I V 0.246 Neutral MSH6 P52701 I1170W 1170 I W 0.988 Pathogenic MSH6 P52701 I1170Y 1170 I Y 0.984 Pathogenic MSH6 P52701 D1171A 1171 D A 0.79 Pathogenic MSH6 P52701 D1171C 1171 D C 0.882 Pathogenic MSH6 P52701 D1171E 1171 D E 0.804 Pathogenic MSH6 P52701 D1171F 1171 D F 0.98 Pathogenic MSH6 P52701 D1171G 1171 D G 0.94 Pathogenic MSH6 P52701 D1171H 1171 D H 0.622 Pathogenic MSH6 P52701 D1171I 1171 D I 0.974 Pathogenic MSH6 P52701 D1171K 1171 D K 0.92 Pathogenic MSH6 P52701 D1171L 1171 D L 0.978 Pathogenic MSH6 P52701 D1171M 1171 D M 0.956 Pathogenic MSH6 P52701 D1171N 1171 D N 0.852 Pathogenic MSH6 P52701 D1171P 1171 D P 0.902 Pathogenic MSH6 P52701 D1171Q 1171 D Q 0.614 Pathogenic MSH6 P52701 D1171R 1171 D R 0.958 Pathogenic MSH6 P52701 D1171S 1171 D S 0.564 Pathogenic MSH6 P52701 D1171T 1171 D T 0.554 Pathogenic MSH6 P52701 D1171V 1171 D V 0.996 Pathogenic MSH6 P52701 D1171W 1171 D W 0.982 Pathogenic MSH6 P52701 D1171Y 1171 D Y 0.974 Pathogenic MSH6 P52701 R1172A 1172 R A 0.324 Neutral MSH6 P52701 R1172C 1172 R C 0.424 Neutral MSH6 P52701 R1172D 1172 R D 0.676 Pathogenic MSH6 P52701 R1172E 1172 R E 0.776 Pathogenic MSH6 P52701 R1172F 1172 R F 0.966 Pathogenic MSH6 P52701 R1172G 1172 R G 0.406 Neutral MSH6 P52701 R1172H 1172 R H 0.354 Neutral MSH6 P52701 R1172I 1172 R I 0.974 Pathogenic MSH6 P52701 R1172K 1172 R K 0.49 Neutral MSH6 P52701 R1172L 1172 R L 0.988 Pathogenic MSH6 P52701 R1172M 1172 R M 0.77 Pathogenic MSH6 P52701 R1172N 1172 R N 0.634 Pathogenic MSH6 P52701 R1172P 1172 R P 0.986 Pathogenic MSH6 P52701 R1172Q 1172 R Q 0.486 Neutral MSH6 P52701 R1172S 1172 R S 0.214 Neutral MSH6 P52701 R1172T 1172 R T 0.934 Pathogenic MSH6 P52701 R1172V 1172 R V 0.974 Pathogenic MSH6 P52701 R1172W 1172 R W 0.95 Pathogenic MSH6 P52701 R1172Y 1172 R Y 0.954 Pathogenic MSH6 P52701 V1173A 1173 V A 0.392 Neutral MSH6 P52701 V1173C 1173 V C 0.772 Pathogenic MSH6 P52701 V1173D 1173 V D 0.848 Pathogenic MSH6 P52701 V1173E 1173 V E 0.964 Pathogenic MSH6 P52701 V1173F 1173 V F 0.9 Pathogenic MSH6 P52701 V1173G 1173 V G 0.894 Pathogenic MSH6 P52701 V1173H 1173 V H 0.864 Pathogenic MSH6 P52701 V1173I 1173 V I 0.176 Neutral MSH6 P52701 V1173K 1173 V K 0.988 Pathogenic MSH6 P52701 V1173L 1173 V L 0.298 Neutral MSH6 P52701 V1173M 1173 V M 0.29 Neutral MSH6 P52701 V1173N 1173 V N 0.914 Pathogenic MSH6 P52701 V1173P 1173 V P 0.982 Pathogenic MSH6 P52701 V1173Q 1173 V Q 0.972 Pathogenic MSH6 P52701 V1173R 1173 V R 0.948 Pathogenic MSH6 P52701 V1173S 1173 V S 0.774 Pathogenic MSH6 P52701 V1173T 1173 V T 0.83 Pathogenic MSH6 P52701 V1173W 1173 V W 0.924 Pathogenic MSH6 P52701 V1173Y 1173 V Y 0.952 Pathogenic MSH6 P52701 F1174A 1174 F A 0.458 Neutral MSH6 P52701 F1174C 1174 F C 0.256 Neutral MSH6 P52701 F1174D 1174 F D 0.75 Pathogenic MSH6 P52701 F1174E 1174 F E 0.816 Pathogenic MSH6 P52701 F1174G 1174 F G 0.464 Neutral MSH6 P52701 F1174H 1174 F H 0.17 Neutral MSH6 P52701 F1174I 1174 F I 0.602 Pathogenic MSH6 P52701 F1174K 1174 F K 0.8 Pathogenic MSH6 P52701 F1174L 1174 F L 0.594 Pathogenic MSH6 P52701 F1174M 1174 F M 0.12 Neutral MSH6 P52701 F1174N 1174 F N 0.666 Pathogenic MSH6 P52701 F1174P 1174 F P 0.93 Pathogenic MSH6 P52701 F1174Q 1174 F Q 0.69 Pathogenic MSH6 P52701 F1174R 1174 F R 0.538 Pathogenic MSH6 P52701 F1174S 1174 F S 0.76 Pathogenic MSH6 P52701 F1174T 1174 F T 0.552 Pathogenic MSH6 P52701 F1174V 1174 F V 0.82 Pathogenic MSH6 P52701 F1174W 1174 F W 0.93 Pathogenic MSH6 P52701 F1174Y 1174 F Y 0.294 Neutral MSH6 P52701 T1175A 1175 T A 0.596 Pathogenic MSH6 P52701 T1175C 1175 T C 0.82 Pathogenic MSH6 P52701 T1175D 1175 T D 0.832 Pathogenic MSH6 P52701 T1175E 1175 T E 0.9 Pathogenic MSH6 P52701 T1175F 1175 T F 0.91 Pathogenic MSH6 P52701 T1175G 1175 T G 0.586 Pathogenic MSH6 P52701 T1175H 1175 T H 0.838 Pathogenic MSH6 P52701 T1175I 1175 T I 0.878 Pathogenic MSH6 P52701 T1175K 1175 T K 0.856 Pathogenic MSH6 P52701 T1175L 1175 T L 0.864 Pathogenic MSH6 P52701 T1175M 1175 T M 0.95 Pathogenic MSH6 P52701 T1175N 1175 T N 0.754 Pathogenic MSH6 P52701 T1175P 1175 T P 0.906 Pathogenic MSH6 P52701 T1175Q 1175 T Q 0.764 Pathogenic MSH6 P52701 T1175R 1175 T R 0.954 Pathogenic MSH6 P52701 T1175S 1175 T S 0.048 Neutral MSH6 P52701 T1175V 1175 T V 0.266 Neutral MSH6 P52701 T1175W 1175 T W 0.994 Pathogenic MSH6 P52701 T1175Y 1175 T Y 0.994 Pathogenic MSH6 P52701 R1176A 1176 R A 0.57 Pathogenic MSH6 P52701 R1176C 1176 R C 0.946 Pathogenic MSH6 P52701 R1176D 1176 R D 0.696 Pathogenic MSH6 P52701 R1176E 1176 R E 0.792 Pathogenic MSH6 P52701 R1176F 1176 R F 0.976 Pathogenic MSH6 P52701 R1176G 1176 R G 0.378 Neutral MSH6 P52701 R1176H 1176 R H 0.404 Neutral MSH6 P52701 R1176I 1176 R I 0.978 Pathogenic MSH6 P52701 R1176K 1176 R K 0.764 Pathogenic MSH6 P52701 R1176L 1176 R L 0.988 Pathogenic MSH6 P52701 R1176M 1176 R M 0.784 Pathogenic MSH6 P52701 R1176N 1176 R N 0.648 Pathogenic MSH6 P52701 R1176P 1176 R P 0.986 Pathogenic MSH6 P52701 R1176Q 1176 R Q 0.508 Pathogenic MSH6 P52701 R1176S 1176 R S 0.9 Pathogenic MSH6 P52701 R1176T 1176 R T 0.936 Pathogenic MSH6 P52701 R1176V 1176 R V 0.976 Pathogenic MSH6 P52701 R1176W 1176 R W 0.956 Pathogenic MSH6 P52701 R1176Y 1176 R Y 0.964 Pathogenic MSH6 P52701 L1177A 1177 L A 0.564 Pathogenic MSH6 P52701 L1177C 1177 L C 0.688 Pathogenic MSH6 P52701 L1177D 1177 L D 0.894 Pathogenic MSH6 P52701 L1177E 1177 L E 0.878 Pathogenic MSH6 P52701 L1177F 1177 L F 0.976 Pathogenic MSH6 P52701 L1177G 1177 L G 0.798 Pathogenic MSH6 P52701 L1177H 1177 L H 0.81 Pathogenic MSH6 P52701 L1177I 1177 L I 0.16 Neutral MSH6 P52701 L1177K 1177 L K 0.746 Pathogenic MSH6 P52701 L1177M 1177 L M 0.174 Neutral MSH6 P52701 L1177N 1177 L N 0.762 Pathogenic MSH6 P52701 L1177P 1177 L P 0.998 Pathogenic MSH6 P52701 L1177Q 1177 L Q 0.33 Neutral MSH6 P52701 L1177R 1177 L R 0.988 Pathogenic MSH6 P52701 L1177S 1177 L S 0.608 Pathogenic MSH6 P52701 L1177T 1177 L T 0.58 Pathogenic MSH6 P52701 L1177V 1177 L V 0.148 Neutral MSH6 P52701 L1177W 1177 L W 0.94 Pathogenic MSH6 P52701 L1177Y 1177 L Y 0.902 Pathogenic MSH6 P52701 G1178A 1178 G A 0.966 Pathogenic MSH6 P52701 G1178C 1178 G C 0.946 Pathogenic MSH6 P52701 G1178D 1178 G D 0.998 Pathogenic MSH6 P52701 G1178E 1178 G E 0.986 Pathogenic MSH6 P52701 G1178F 1178 G F 0.98 Pathogenic MSH6 P52701 G1178H 1178 G H 0.984 Pathogenic MSH6 P52701 G1178I 1178 G I 0.972 Pathogenic MSH6 P52701 G1178K 1178 G K 0.984 Pathogenic MSH6 P52701 G1178L 1178 G L 0.982 Pathogenic MSH6 P52701 G1178M 1178 G M 0.994 Pathogenic MSH6 P52701 G1178N 1178 G N 0.986 Pathogenic MSH6 P52701 G1178P 1178 G P 0.962 Pathogenic MSH6 P52701 G1178Q 1178 G Q 0.994 Pathogenic MSH6 P52701 G1178R 1178 G R 1 Pathogenic MSH6 P52701 G1178S 1178 G S 0.824 Pathogenic MSH6 P52701 G1178T 1178 G T 0.838 Pathogenic MSH6 P52701 G1178V 1178 G V 0.984 Pathogenic MSH6 P52701 G1178W 1178 G W 0.976 Pathogenic MSH6 P52701 G1178Y 1178 G Y 0.956 Pathogenic MSH6 P52701 A1179C 1179 A C 0.716 Pathogenic MSH6 P52701 A1179D 1179 A D 0.926 Pathogenic MSH6 P52701 A1179E 1179 A E 0.876 Pathogenic MSH6 P52701 A1179F 1179 A F 0.966 Pathogenic MSH6 P52701 A1179G 1179 A G 0.756 Pathogenic MSH6 P52701 A1179H 1179 A H 0.864 Pathogenic MSH6 P52701 A1179I 1179 A I 0.96 Pathogenic MSH6 P52701 A1179K 1179 A K 0.936 Pathogenic MSH6 P52701 A1179L 1179 A L 0.98 Pathogenic MSH6 P52701 A1179M 1179 A M 0.85 Pathogenic MSH6 P52701 A1179N 1179 A N 0.862 Pathogenic MSH6 P52701 A1179P 1179 A P 0.968 Pathogenic MSH6 P52701 A1179Q 1179 A Q 0.816 Pathogenic MSH6 P52701 A1179R 1179 A R 0.958 Pathogenic MSH6 P52701 A1179S 1179 A S 0.42 Neutral MSH6 P52701 A1179T 1179 A T 0.728 Pathogenic MSH6 P52701 A1179V 1179 A V 0.91 Pathogenic MSH6 P52701 A1179W 1179 A W 0.976 Pathogenic MSH6 P52701 A1179Y 1179 A Y 0.964 Pathogenic MSH6 P52701 T118A 118 T A 0.06 Neutral MSH6 P52701 T118C 118 T C 0.034 Neutral MSH6 P52701 T118D 118 T D 0.058 Neutral MSH6 P52701 T118E 118 T E 0.05 Neutral MSH6 P52701 T118F 118 T F 0.214 Neutral MSH6 P52701 T118G 118 T G 0.058 Neutral MSH6 P52701 T118H 118 T H 0.084 Neutral MSH6 P52701 T118I 118 T I 0.096 Neutral MSH6 P52701 T118K 118 T K 0.004 Neutral MSH6 P52701 T118L 118 T L 0.07 Neutral MSH6 P52701 T118M 118 T M 0.098 Neutral MSH6 P52701 T118N 118 T N 0.02 Neutral MSH6 P52701 T118P 118 T P 0.1 Neutral MSH6 P52701 T118Q 118 T Q 0 Neutral MSH6 P52701 T118R 118 T R 0.26 Neutral MSH6 P52701 T118S 118 T S 0.004 Neutral MSH6 P52701 T118V 118 T V 0.212 Neutral MSH6 P52701 T118W 118 T W 0.466 Neutral MSH6 P52701 T118Y 118 T Y 0.424 Neutral MSH6 P52701 S1180A 1180 S A 0.28 Neutral MSH6 P52701 S1180C 1180 S C 0.52 Pathogenic MSH6 P52701 S1180D 1180 S D 0.56 Pathogenic MSH6 P52701 S1180E 1180 S E 0.764 Pathogenic MSH6 P52701 S1180F 1180 S F 0.894 Pathogenic MSH6 P52701 S1180G 1180 S G 0.088 Neutral MSH6 P52701 S1180H 1180 S H 0.528 Pathogenic MSH6 P52701 S1180I 1180 S I 0.636 Pathogenic MSH6 P52701 S1180K 1180 S K 0.466 Neutral MSH6 P52701 S1180L 1180 S L 0.654 Pathogenic MSH6 P52701 S1180M 1180 S M 0.978 Pathogenic MSH6 P52701 S1180N 1180 S N 0.058 Neutral MSH6 P52701 S1180P 1180 S P 0.668 Pathogenic MSH6 P52701 S1180Q 1180 S Q 0.494 Neutral MSH6 P52701 S1180R 1180 S R 0.49 Neutral MSH6 P52701 S1180T 1180 S T 0.32 Neutral MSH6 P52701 S1180V 1180 S V 0.82 Pathogenic MSH6 P52701 S1180W 1180 S W 0.952 Pathogenic MSH6 P52701 S1180Y 1180 S Y 0.91 Pathogenic MSH6 P52701 D1181A 1181 D A 0.79 Pathogenic MSH6 P52701 D1181C 1181 D C 0.882 Pathogenic MSH6 P52701 D1181E 1181 D E 0.796 Pathogenic MSH6 P52701 D1181F 1181 D F 0.98 Pathogenic MSH6 P52701 D1181G 1181 D G 0.94 Pathogenic MSH6 P52701 D1181H 1181 D H 0.62 Pathogenic MSH6 P52701 D1181I 1181 D I 0.974 Pathogenic MSH6 P52701 D1181K 1181 D K 0.912 Pathogenic MSH6 P52701 D1181L 1181 D L 0.978 Pathogenic MSH6 P52701 D1181M 1181 D M 0.956 Pathogenic MSH6 P52701 D1181N 1181 D N 0.852 Pathogenic MSH6 P52701 D1181P 1181 D P 0.902 Pathogenic MSH6 P52701 D1181Q 1181 D Q 0.606 Pathogenic MSH6 P52701 D1181R 1181 D R 0.958 Pathogenic MSH6 P52701 D1181S 1181 D S 0.35 Neutral MSH6 P52701 D1181T 1181 D T 0.796 Pathogenic MSH6 P52701 D1181V 1181 D V 0.996 Pathogenic MSH6 P52701 D1181W 1181 D W 0.982 Pathogenic MSH6 P52701 D1181Y 1181 D Y 0.974 Pathogenic MSH6 P52701 R1182A 1182 R A 0.438 Neutral MSH6 P52701 R1182C 1182 R C 0.656 Pathogenic MSH6 P52701 R1182D 1182 R D 0.042 Neutral MSH6 P52701 R1182E 1182 R E 0.54 Pathogenic MSH6 P52701 R1182F 1182 R F 0.936 Pathogenic MSH6 P52701 R1182G 1182 R G 0.21 Neutral MSH6 P52701 R1182H 1182 R H 0.01 Neutral MSH6 P52701 R1182I 1182 R I 0.902 Pathogenic MSH6 P52701 R1182K 1182 R K 0.26 Neutral MSH6 P52701 R1182L 1182 R L 0.88 Pathogenic MSH6 P52701 R1182M 1182 R M 0.668 Pathogenic MSH6 P52701 R1182N 1182 R N 0.026 Neutral MSH6 P52701 R1182P 1182 R P 0.846 Pathogenic MSH6 P52701 R1182Q 1182 R Q 0.016 Neutral MSH6 P52701 R1182S 1182 R S 0.124 Neutral MSH6 P52701 R1182T 1182 R T 0.536 Pathogenic MSH6 P52701 R1182V 1182 R V 0.822 Pathogenic MSH6 P52701 R1182W 1182 R W 0.914 Pathogenic MSH6 P52701 R1182Y 1182 R Y 0.892 Pathogenic MSH6 P52701 I1183A 1183 I A 0.108 Neutral MSH6 P52701 I1183C 1183 I C 0.138 Neutral MSH6 P52701 I1183D 1183 I D 0.212 Neutral MSH6 P52701 I1183E 1183 I E 0.202 Neutral MSH6 P52701 I1183F 1183 I F 0.332 Neutral MSH6 P52701 I1183G 1183 I G 0.27 Neutral MSH6 P52701 I1183H 1183 I H 0.142 Neutral MSH6 P52701 I1183K 1183 I K 0.218 Neutral MSH6 P52701 I1183L 1183 I L 0.164 Neutral MSH6 P52701 I1183M 1183 I M 0.026 Neutral MSH6 P52701 I1183N 1183 I N 0.25 Neutral MSH6 P52701 I1183P 1183 I P 0.246 Neutral MSH6 P52701 I1183Q 1183 I Q 0.25 Neutral MSH6 P52701 I1183R 1183 I R 0.452 Neutral MSH6 P52701 I1183S 1183 I S 0.212 Neutral MSH6 P52701 I1183T 1183 I T 0.16 Neutral MSH6 P52701 I1183V 1183 I V 0.17 Neutral MSH6 P52701 I1183W 1183 I W 0.518 Pathogenic MSH6 P52701 I1183Y 1183 I Y 0.476 Neutral MSH6 P52701 M1184A 1184 M A 0.228 Neutral MSH6 P52701 M1184C 1184 M C 0.248 Neutral MSH6 P52701 M1184D 1184 M D 0.674 Pathogenic MSH6 P52701 M1184E 1184 M E 0.442 Neutral MSH6 P52701 M1184F 1184 M F 0.078 Neutral MSH6 P52701 M1184G 1184 M G 0.288 Neutral MSH6 P52701 M1184H 1184 M H 0.514 Pathogenic MSH6 P52701 M1184I 1184 M I 0.082 Neutral MSH6 P52701 M1184K 1184 M K 0.69 Pathogenic MSH6 P52701 M1184L 1184 M L 0.042 Neutral MSH6 P52701 M1184N 1184 M N 0.694 Pathogenic MSH6 P52701 M1184P 1184 M P 0.872 Pathogenic MSH6 P52701 M1184Q 1184 M Q 0.37 Neutral MSH6 P52701 M1184R 1184 M R 0.482 Neutral MSH6 P52701 M1184S 1184 M S 0.036 Neutral MSH6 P52701 M1184T 1184 M T 0.034 Neutral MSH6 P52701 M1184V 1184 M V 0.216 Neutral MSH6 P52701 M1184W 1184 M W 0.948 Pathogenic MSH6 P52701 M1184Y 1184 M Y 0.884 Pathogenic MSH6 P52701 S1185A 1185 S A 0.168 Neutral MSH6 P52701 S1185C 1185 S C 0.198 Neutral MSH6 P52701 S1185D 1185 S D 0.694 Pathogenic MSH6 P52701 S1185E 1185 S E 0.572 Pathogenic MSH6 P52701 S1185F 1185 S F 0.936 Pathogenic MSH6 P52701 S1185G 1185 S G 0.092 Neutral MSH6 P52701 S1185H 1185 S H 0.876 Pathogenic MSH6 P52701 S1185I 1185 S I 0.756 Pathogenic MSH6 P52701 S1185K 1185 S K 0.832 Pathogenic MSH6 P52701 S1185L 1185 S L 0.5 Pathogenic MSH6 P52701 S1185M 1185 S M 0.952 Pathogenic MSH6 P52701 S1185N 1185 S N 0.662 Pathogenic MSH6 P52701 S1185P 1185 S P 0.816 Pathogenic MSH6 P52701 S1185Q 1185 S Q 0.536 Pathogenic MSH6 P52701 S1185R 1185 S R 0.68 Pathogenic MSH6 P52701 S1185T 1185 S T 0.26 Neutral MSH6 P52701 S1185V 1185 S V 0.48 Neutral MSH6 P52701 S1185W 1185 S W 0.888 Pathogenic MSH6 P52701 S1185Y 1185 S Y 0.888 Pathogenic MSH6 P52701 G1186A 1186 G A 0.344 Neutral MSH6 P52701 G1186C 1186 G C 0.94 Pathogenic MSH6 P52701 G1186D 1186 G D 0.974 Pathogenic MSH6 P52701 G1186E 1186 G E 0.638 Pathogenic MSH6 P52701 G1186F 1186 G F 0.988 Pathogenic MSH6 P52701 G1186H 1186 G H 0.992 Pathogenic MSH6 P52701 G1186I 1186 G I 0.978 Pathogenic MSH6 P52701 G1186K 1186 G K 0.992 Pathogenic MSH6 P52701 G1186L 1186 G L 0.988 Pathogenic MSH6 P52701 G1186M 1186 G M 0.994 Pathogenic MSH6 P52701 G1186N 1186 G N 0.592 Pathogenic MSH6 P52701 G1186P 1186 G P 0.982 Pathogenic MSH6 P52701 G1186Q 1186 G Q 0.988 Pathogenic MSH6 P52701 G1186R 1186 G R 0.76 Pathogenic MSH6 P52701 G1186S 1186 G S 0.346 Neutral MSH6 P52701 G1186T 1186 G T 0.914 Pathogenic MSH6 P52701 G1186V 1186 G V 0.99 Pathogenic MSH6 P52701 G1186W 1186 G W 0.984 Pathogenic MSH6 P52701 G1186Y 1186 G Y 0.984 Pathogenic MSH6 P52701 E1187A 1187 E A 0.708 Pathogenic MSH6 P52701 E1187C 1187 E C 0.648 Pathogenic MSH6 P52701 E1187D 1187 E D 0.746 Pathogenic MSH6 P52701 E1187F 1187 E F 0.956 Pathogenic MSH6 P52701 E1187G 1187 E G 0.376 Neutral MSH6 P52701 E1187H 1187 E H 0.258 Neutral MSH6 P52701 E1187I 1187 E I 0.98 Pathogenic MSH6 P52701 E1187K 1187 E K 0.4 Neutral MSH6 P52701 E1187L 1187 E L 0.976 Pathogenic MSH6 P52701 E1187M 1187 E M 0.894 Pathogenic MSH6 P52701 E1187N 1187 E N 0.214 Neutral MSH6 P52701 E1187P 1187 E P 0.93 Pathogenic MSH6 P52701 E1187Q 1187 E Q 0.058 Neutral MSH6 P52701 E1187R 1187 E R 0.32 Neutral MSH6 P52701 E1187S 1187 E S 0.158 Neutral MSH6 P52701 E1187T 1187 E T 0.854 Pathogenic MSH6 P52701 E1187V 1187 E V 0.916 Pathogenic MSH6 P52701 E1187W 1187 E W 0.986 Pathogenic MSH6 P52701 E1187Y 1187 E Y 0.966 Pathogenic MSH6 P52701 S1188A 1188 S A 0.87 Pathogenic MSH6 P52701 S1188C 1188 S C 0.904 Pathogenic MSH6 P52701 S1188D 1188 S D 0.698 Pathogenic MSH6 P52701 S1188E 1188 S E 0.962 Pathogenic MSH6 P52701 S1188F 1188 S F 0.982 Pathogenic MSH6 P52701 S1188G 1188 S G 0.696 Pathogenic MSH6 P52701 S1188H 1188 S H 0.974 Pathogenic MSH6 P52701 S1188I 1188 S I 0.886 Pathogenic MSH6 P52701 S1188K 1188 S K 0.954 Pathogenic MSH6 P52701 S1188L 1188 S L 0.926 Pathogenic MSH6 P52701 S1188M 1188 S M 0.998 Pathogenic MSH6 P52701 S1188N 1188 S N 0.892 Pathogenic MSH6 P52701 S1188P 1188 S P 0.97 Pathogenic MSH6 P52701 S1188Q 1188 S Q 0.952 Pathogenic MSH6 P52701 S1188R 1188 S R 0.972 Pathogenic MSH6 P52701 S1188T 1188 S T 0.712 Pathogenic MSH6 P52701 S1188V 1188 S V 0.954 Pathogenic MSH6 P52701 S1188W 1188 S W 0.954 Pathogenic MSH6 P52701 S1188Y 1188 S Y 0.962 Pathogenic MSH6 P52701 T1189A 1189 T A 0.714 Pathogenic MSH6 P52701 T1189C 1189 T C 0.942 Pathogenic MSH6 P52701 T1189D 1189 T D 0.954 Pathogenic MSH6 P52701 T1189E 1189 T E 0.952 Pathogenic MSH6 P52701 T1189F 1189 T F 0.95 Pathogenic MSH6 P52701 T1189G 1189 T G 0.746 Pathogenic MSH6 P52701 T1189H 1189 T H 0.924 Pathogenic MSH6 P52701 T1189I 1189 T I 0.952 Pathogenic MSH6 P52701 T1189K 1189 T K 0.94 Pathogenic MSH6 P52701 T1189L 1189 T L 0.952 Pathogenic MSH6 P52701 T1189M 1189 T M 0.984 Pathogenic MSH6 P52701 T1189N 1189 T N 0.898 Pathogenic MSH6 P52701 T1189P 1189 T P 0.968 Pathogenic MSH6 P52701 T1189Q 1189 T Q 0.894 Pathogenic MSH6 P52701 T1189R 1189 T R 0.994 Pathogenic MSH6 P52701 T1189S 1189 T S 0.83 Pathogenic MSH6 P52701 T1189V 1189 T V 0.84 Pathogenic MSH6 P52701 T1189W 1189 T W 0.974 Pathogenic MSH6 P52701 T1189Y 1189 T Y 0.974 Pathogenic MSH6 P52701 F119A 119 F A 0.1 Neutral MSH6 P52701 F119C 119 F C 0.008 Neutral MSH6 P52701 F119D 119 F D 0.162 Neutral MSH6 P52701 F119E 119 F E 0.192 Neutral MSH6 P52701 F119G 119 F G 0.136 Neutral MSH6 P52701 F119H 119 F H 0.002 Neutral MSH6 P52701 F119I 119 F I 0 Neutral MSH6 P52701 F119K 119 F K 0.174 Neutral MSH6 P52701 F119L 119 F L 0.002 Neutral MSH6 P52701 F119M 119 F M 0.086 Neutral MSH6 P52701 F119N 119 F N 0.174 Neutral MSH6 P52701 F119P 119 F P 0.178 Neutral MSH6 P52701 F119Q 119 F Q 0.038 Neutral MSH6 P52701 F119R 119 F R 0.142 Neutral MSH6 P52701 F119S 119 F S 0.156 Neutral MSH6 P52701 F119T 119 F T 0.224 Neutral MSH6 P52701 F119V 119 F V 0.166 Neutral MSH6 P52701 F119W 119 F W 0.268 Neutral MSH6 P52701 F119Y 119 F Y 0.1 Neutral MSH6 P52701 F1190A 1190 F A 0.502 Pathogenic MSH6 P52701 F1190C 1190 F C 0.732 Pathogenic MSH6 P52701 F1190D 1190 F D 0.82 Pathogenic MSH6 P52701 F1190E 1190 F E 0.87 Pathogenic MSH6 P52701 F1190G 1190 F G 0.518 Pathogenic MSH6 P52701 F1190H 1190 F H 0.768 Pathogenic MSH6 P52701 F1190I 1190 F I 0.68 Pathogenic MSH6 P52701 F1190K 1190 F K 0.848 Pathogenic MSH6 P52701 F1190L 1190 F L 0.348 Neutral MSH6 P52701 F1190M 1190 F M 0.788 Pathogenic MSH6 P52701 F1190N 1190 F N 0.77 Pathogenic MSH6 P52701 F1190P 1190 F P 0.958 Pathogenic MSH6 P52701 F1190Q 1190 F Q 0.788 Pathogenic MSH6 P52701 F1190R 1190 F R 0.918 Pathogenic MSH6 P52701 F1190S 1190 F S 0.888 Pathogenic MSH6 P52701 F1190T 1190 F T 0.596 Pathogenic MSH6 P52701 F1190V 1190 F V 0.74 Pathogenic MSH6 P52701 F1190W 1190 F W 0.864 Pathogenic MSH6 P52701 F1190Y 1190 F Y 0.55 Pathogenic MSH6 P52701 F1191A 1191 F A 0.422 Neutral MSH6 P52701 F1191C 1191 F C 0.582 Pathogenic MSH6 P52701 F1191D 1191 F D 0.81 Pathogenic MSH6 P52701 F1191E 1191 F E 0.89 Pathogenic MSH6 P52701 F1191G 1191 F G 0.49 Neutral MSH6 P52701 F1191H 1191 F H 0.646 Pathogenic MSH6 P52701 F1191I 1191 F I 0.562 Pathogenic MSH6 P52701 F1191K 1191 F K 0.86 Pathogenic MSH6 P52701 F1191L 1191 F L 0.07 Neutral MSH6 P52701 F1191M 1191 F M 0.078 Neutral MSH6 P52701 F1191N 1191 F N 0.728 Pathogenic MSH6 P52701 F1191P 1191 F P 0.928 Pathogenic MSH6 P52701 F1191Q 1191 F Q 0.454 Neutral MSH6 P52701 F1191R 1191 F R 0.928 Pathogenic MSH6 P52701 F1191S 1191 F S 0.742 Pathogenic MSH6 P52701 F1191T 1191 F T 0.572 Pathogenic MSH6 P52701 F1191V 1191 F V 0.8 Pathogenic MSH6 P52701 F1191W 1191 F W 0.926 Pathogenic MSH6 P52701 F1191Y 1191 F Y 0.22 Neutral MSH6 P52701 V1192A 1192 V A 0.486 Neutral MSH6 P52701 V1192C 1192 V C 0.802 Pathogenic MSH6 P52701 V1192D 1192 V D 0.858 Pathogenic MSH6 P52701 V1192E 1192 V E 0.962 Pathogenic MSH6 P52701 V1192F 1192 V F 0.93 Pathogenic MSH6 P52701 V1192G 1192 V G 0.914 Pathogenic MSH6 P52701 V1192H 1192 V H 0.898 Pathogenic MSH6 P52701 V1192I 1192 V I 0.276 Neutral MSH6 P52701 V1192K 1192 V K 0.986 Pathogenic MSH6 P52701 V1192L 1192 V L 0.322 Neutral MSH6 P52701 V1192M 1192 V M 0.486 Neutral MSH6 P52701 V1192N 1192 V N 0.92 Pathogenic MSH6 P52701 V1192P 1192 V P 0.986 Pathogenic MSH6 P52701 V1192Q 1192 V Q 0.97 Pathogenic MSH6 P52701 V1192R 1192 V R 0.948 Pathogenic MSH6 P52701 V1192S 1192 V S 0.806 Pathogenic MSH6 P52701 V1192T 1192 V T 0.182 Neutral MSH6 P52701 V1192W 1192 V W 0.954 Pathogenic MSH6 P52701 V1192Y 1192 V Y 0.974 Pathogenic MSH6 P52701 E1193A 1193 E A 0.81 Pathogenic MSH6 P52701 E1193C 1193 E C 0.764 Pathogenic MSH6 P52701 E1193D 1193 E D 0.894 Pathogenic MSH6 P52701 E1193F 1193 E F 0.96 Pathogenic MSH6 P52701 E1193G 1193 E G 0.314 Neutral MSH6 P52701 E1193H 1193 E H 0.746 Pathogenic MSH6 P52701 E1193I 1193 E I 0.984 Pathogenic MSH6 P52701 E1193K 1193 E K 0.918 Pathogenic MSH6 P52701 E1193L 1193 E L 0.974 Pathogenic MSH6 P52701 E1193M 1193 E M 0.91 Pathogenic MSH6 P52701 E1193N 1193 E N 0.782 Pathogenic MSH6 P52701 E1193P 1193 E P 0.938 Pathogenic MSH6 P52701 E1193Q 1193 E Q 0.854 Pathogenic MSH6 P52701 E1193R 1193 E R 0.934 Pathogenic MSH6 P52701 E1193S 1193 E S 0.892 Pathogenic MSH6 P52701 E1193T 1193 E T 0.84 Pathogenic MSH6 P52701 E1193V 1193 E V 0.922 Pathogenic MSH6 P52701 E1193W 1193 E W 0.978 Pathogenic MSH6 P52701 E1193Y 1193 E Y 0.958 Pathogenic MSH6 P52701 L1194A 1194 L A 0.702 Pathogenic MSH6 P52701 L1194C 1194 L C 0.806 Pathogenic MSH6 P52701 L1194D 1194 L D 0.884 Pathogenic MSH6 P52701 L1194E 1194 L E 0.866 Pathogenic MSH6 P52701 L1194F 1194 L F 0.828 Pathogenic MSH6 P52701 L1194G 1194 L G 0.858 Pathogenic MSH6 P52701 L1194H 1194 L H 0.898 Pathogenic MSH6 P52701 L1194I 1194 L I 0.524 Pathogenic MSH6 P52701 L1194K 1194 L K 0.69 Pathogenic MSH6 P52701 L1194M 1194 L M 0.174 Neutral MSH6 P52701 L1194N 1194 L N 0.796 Pathogenic MSH6 P52701 L1194P 1194 L P 0.966 Pathogenic MSH6 P52701 L1194Q 1194 L Q 0.756 Pathogenic MSH6 P52701 L1194R 1194 L R 0.974 Pathogenic MSH6 P52701 L1194S 1194 L S 0.68 Pathogenic MSH6 P52701 L1194T 1194 L T 0.598 Pathogenic MSH6 P52701 L1194V 1194 L V 0.098 Neutral MSH6 P52701 L1194W 1194 L W 0.846 Pathogenic MSH6 P52701 L1194Y 1194 L Y 0.868 Pathogenic MSH6 P52701 S1195A 1195 S A 0.138 Neutral MSH6 P52701 S1195C 1195 S C 0.318 Neutral MSH6 P52701 S1195D 1195 S D 0.704 Pathogenic MSH6 P52701 S1195E 1195 S E 0.642 Pathogenic MSH6 P52701 S1195F 1195 S F 0.95 Pathogenic MSH6 P52701 S1195G 1195 S G 0.492 Neutral MSH6 P52701 S1195H 1195 S H 0.886 Pathogenic MSH6 P52701 S1195I 1195 S I 0.702 Pathogenic MSH6 P52701 S1195K 1195 S K 0.538 Pathogenic MSH6 P52701 S1195L 1195 S L 0.414 Neutral MSH6 P52701 S1195M 1195 S M 0.68 Pathogenic MSH6 P52701 S1195N 1195 S N 0.168 Neutral MSH6 P52701 S1195P 1195 S P 0.818 Pathogenic MSH6 P52701 S1195Q 1195 S Q 0.542 Pathogenic MSH6 P52701 S1195R 1195 S R 0.538 Pathogenic MSH6 P52701 S1195T 1195 S T 0.634 Pathogenic MSH6 P52701 S1195V 1195 S V 0.828 Pathogenic MSH6 P52701 S1195W 1195 S W 0.912 Pathogenic MSH6 P52701 S1195Y 1195 S Y 0.794 Pathogenic MSH6 P52701 E1196A 1196 E A 0.81 Pathogenic MSH6 P52701 E1196C 1196 E C 0.764 Pathogenic MSH6 P52701 E1196D 1196 E D 0.894 Pathogenic MSH6 P52701 E1196F 1196 E F 0.96 Pathogenic MSH6 P52701 E1196G 1196 E G 0.314 Neutral MSH6 P52701 E1196H 1196 E H 0.746 Pathogenic MSH6 P52701 E1196I 1196 E I 0.984 Pathogenic MSH6 P52701 E1196K 1196 E K 0.918 Pathogenic MSH6 P52701 E1196L 1196 E L 0.974 Pathogenic MSH6 P52701 E1196M 1196 E M 0.91 Pathogenic MSH6 P52701 E1196N 1196 E N 0.782 Pathogenic MSH6 P52701 E1196P 1196 E P 0.938 Pathogenic MSH6 P52701 E1196Q 1196 E Q 0.854 Pathogenic MSH6 P52701 E1196R 1196 E R 0.934 Pathogenic MSH6 P52701 E1196S 1196 E S 0.892 Pathogenic MSH6 P52701 E1196T 1196 E T 0.84 Pathogenic MSH6 P52701 E1196V 1196 E V 0.922 Pathogenic MSH6 P52701 E1196W 1196 E W 0.978 Pathogenic MSH6 P52701 E1196Y 1196 E Y 0.958 Pathogenic MSH6 P52701 T1197A 1197 T A 0.402 Neutral MSH6 P52701 T1197C 1197 T C 0.938 Pathogenic MSH6 P52701 T1197D 1197 T D 0.95 Pathogenic MSH6 P52701 T1197E 1197 T E 0.95 Pathogenic MSH6 P52701 T1197F 1197 T F 0.95 Pathogenic MSH6 P52701 T1197G 1197 T G 0.744 Pathogenic MSH6 P52701 T1197H 1197 T H 0.922 Pathogenic MSH6 P52701 T1197I 1197 T I 0.952 Pathogenic MSH6 P52701 T1197K 1197 T K 0.94 Pathogenic MSH6 P52701 T1197L 1197 T L 0.95 Pathogenic MSH6 P52701 T1197M 1197 T M 0.982 Pathogenic MSH6 P52701 T1197N 1197 T N 0.896 Pathogenic MSH6 P52701 T1197P 1197 T P 0.966 Pathogenic MSH6 P52701 T1197Q 1197 T Q 0.892 Pathogenic MSH6 P52701 T1197R 1197 T R 0.994 Pathogenic MSH6 P52701 T1197S 1197 T S 0.828 Pathogenic MSH6 P52701 T1197V 1197 T V 0.83 Pathogenic MSH6 P52701 T1197W 1197 T W 0.972 Pathogenic MSH6 P52701 T1197Y 1197 T Y 0.972 Pathogenic MSH6 P52701 A1198C 1198 A C 0.622 Pathogenic MSH6 P52701 A1198D 1198 A D 0.674 Pathogenic MSH6 P52701 A1198E 1198 A E 0.852 Pathogenic MSH6 P52701 A1198F 1198 A F 0.948 Pathogenic MSH6 P52701 A1198G 1198 A G 0.494 Neutral MSH6 P52701 A1198H 1198 A H 0.842 Pathogenic MSH6 P52701 A1198I 1198 A I 0.916 Pathogenic MSH6 P52701 A1198K 1198 A K 0.548 Pathogenic MSH6 P52701 A1198L 1198 A L 0.57 Pathogenic MSH6 P52701 A1198M 1198 A M 0.804 Pathogenic MSH6 P52701 A1198N 1198 A N 0.582 Pathogenic MSH6 P52701 A1198P 1198 A P 0.908 Pathogenic MSH6 P52701 A1198Q 1198 A Q 0.498 Neutral MSH6 P52701 A1198R 1198 A R 0.896 Pathogenic MSH6 P52701 A1198S 1198 A S 0.014 Neutral MSH6 P52701 A1198T 1198 A T 0.408 Neutral MSH6 P52701 A1198V 1198 A V 0.734 Pathogenic MSH6 P52701 A1198W 1198 A W 0.942 Pathogenic MSH6 P52701 A1198Y 1198 A Y 0.916 Pathogenic MSH6 P52701 S1199A 1199 S A 0.054 Neutral MSH6 P52701 S1199C 1199 S C 0.354 Neutral MSH6 P52701 S1199D 1199 S D 0.5 Pathogenic MSH6 P52701 S1199E 1199 S E 0.74 Pathogenic MSH6 P52701 S1199F 1199 S F 0.884 Pathogenic MSH6 P52701 S1199G 1199 S G 0.232 Neutral MSH6 P52701 S1199H 1199 S H 0.806 Pathogenic MSH6 P52701 S1199I 1199 S I 0.352 Neutral MSH6 P52701 S1199K 1199 S K 0.448 Neutral MSH6 P52701 S1199L 1199 S L 0.154 Neutral MSH6 P52701 S1199M 1199 S M 0.902 Pathogenic MSH6 P52701 S1199N 1199 S N 0.072 Neutral MSH6 P52701 S1199P 1199 S P 0.604 Pathogenic MSH6 P52701 S1199Q 1199 S Q 0.696 Pathogenic MSH6 P52701 S1199R 1199 S R 0.69 Pathogenic MSH6 P52701 S1199T 1199 S T 0.056 Neutral MSH6 P52701 S1199V 1199 S V 0.1 Neutral MSH6 P52701 S1199W 1199 S W 0.952 Pathogenic MSH6 P52701 S1199Y 1199 S Y 0.932 Pathogenic MSH6 P52701 P12A 12 P A 0.176 Neutral MSH6 P52701 P12C 12 P C 0.148 Neutral MSH6 P52701 P12D 12 P D 0.078 Neutral MSH6 P52701 P12E 12 P E 0.214 Neutral MSH6 P52701 P12F 12 P F 0.248 Neutral MSH6 P52701 P12G 12 P G 0.092 Neutral MSH6 P52701 P12H 12 P H 0.266 Neutral MSH6 P52701 P12I 12 P I 0.104 Neutral MSH6 P52701 P12K 12 P K 0.206 Neutral MSH6 P52701 P12L 12 P L 0.108 Neutral MSH6 P52701 P12M 12 P M 0.22 Neutral MSH6 P52701 P12N 12 P N 0.048 Neutral MSH6 P52701 P12Q 12 P Q 0.212 Neutral MSH6 P52701 P12R 12 P R 0.306 Neutral MSH6 P52701 P12S 12 P S 0.092 Neutral MSH6 P52701 P12T 12 P T 0.012 Neutral MSH6 P52701 P12V 12 P V 0.14 Neutral MSH6 P52701 P12W 12 P W 0.39 Neutral MSH6 P52701 P12Y 12 P Y 0.32 Neutral MSH6 P52701 I120A 120 I A 0.072 Neutral MSH6 P52701 I120C 120 I C 0.09 Neutral MSH6 P52701 I120D 120 I D 0.14 Neutral MSH6 P52701 I120E 120 I E 0.132 Neutral MSH6 P52701 I120F 120 I F 0.088 Neutral MSH6 P52701 I120G 120 I G 0.206 Neutral MSH6 P52701 I120H 120 I H 0.08 Neutral MSH6 P52701 I120K 120 I K 0.118 Neutral MSH6 P52701 I120L 120 I L 0 Neutral MSH6 P52701 I120M 120 I M 0.02 Neutral MSH6 P52701 I120N 120 I N 0.176 Neutral MSH6 P52701 I120P 120 I P 0.174 Neutral MSH6 P52701 I120Q 120 I Q 0.174 Neutral MSH6 P52701 I120R 120 I R 0.26 Neutral MSH6 P52701 I120S 120 I S 0.16 Neutral MSH6 P52701 I120T 120 I T 0.002 Neutral MSH6 P52701 I120V 120 I V 0 Neutral MSH6 P52701 I120W 120 I W 0.294 Neutral MSH6 P52701 I120Y 120 I Y 0.298 Neutral MSH6 P52701 I1200A 1200 I A 0.158 Neutral MSH6 P52701 I1200C 1200 I C 0.662 Pathogenic MSH6 P52701 I1200D 1200 I D 0.746 Pathogenic MSH6 P52701 I1200E 1200 I E 0.75 Pathogenic MSH6 P52701 I1200F 1200 I F 0.948 Pathogenic MSH6 P52701 I1200G 1200 I G 0.812 Pathogenic MSH6 P52701 I1200H 1200 I H 0.898 Pathogenic MSH6 P52701 I1200K 1200 I K 0.844 Pathogenic MSH6 P52701 I1200L 1200 I L 0.722 Pathogenic MSH6 P52701 I1200M 1200 I M 0.168 Neutral MSH6 P52701 I1200N 1200 I N 0.77 Pathogenic MSH6 P52701 I1200P 1200 I P 0.924 Pathogenic MSH6 P52701 I1200Q 1200 I Q 0.782 Pathogenic MSH6 P52701 I1200R 1200 I R 0.864 Pathogenic MSH6 P52701 I1200S 1200 I S 0.652 Pathogenic MSH6 P52701 I1200T 1200 I T 0.342 Neutral MSH6 P52701 I1200V 1200 I V 0.118 Neutral MSH6 P52701 I1200W 1200 I W 0.99 Pathogenic MSH6 P52701 I1200Y 1200 I Y 0.978 Pathogenic MSH6 P52701 L1201A 1201 L A 0.714 Pathogenic MSH6 P52701 L1201C 1201 L C 0.816 Pathogenic MSH6 P52701 L1201D 1201 L D 0.9 Pathogenic MSH6 P52701 L1201E 1201 L E 0.882 Pathogenic MSH6 P52701 L1201F 1201 L F 0.676 Pathogenic MSH6 P52701 L1201G 1201 L G 0.87 Pathogenic MSH6 P52701 L1201H 1201 L H 0.906 Pathogenic MSH6 P52701 L1201I 1201 L I 0.306 Neutral MSH6 P52701 L1201K 1201 L K 0.71 Pathogenic MSH6 P52701 L1201M 1201 L M 0.588 Pathogenic MSH6 P52701 L1201N 1201 L N 0.81 Pathogenic MSH6 P52701 L1201P 1201 L P 0.978 Pathogenic MSH6 P52701 L1201Q 1201 L Q 0.764 Pathogenic MSH6 P52701 L1201R 1201 L R 0.982 Pathogenic MSH6 P52701 L1201S 1201 L S 0.698 Pathogenic MSH6 P52701 L1201T 1201 L T 0.614 Pathogenic MSH6 P52701 L1201V 1201 L V 0.122 Neutral MSH6 P52701 L1201W 1201 L W 0.862 Pathogenic MSH6 P52701 L1201Y 1201 L Y 0.878 Pathogenic MSH6 P52701 M1202A 1202 M A 0.112 Neutral MSH6 P52701 M1202C 1202 M C 0.194 Neutral MSH6 P52701 M1202D 1202 M D 0.172 Neutral MSH6 P52701 M1202E 1202 M E 0.174 Neutral MSH6 P52701 M1202F 1202 M F 0.764 Pathogenic MSH6 P52701 M1202G 1202 M G 0.314 Neutral MSH6 P52701 M1202H 1202 M H 0.024 Neutral MSH6 P52701 M1202I 1202 M I 0.498 Neutral MSH6 P52701 M1202K 1202 M K 0.08 Neutral MSH6 P52701 M1202L 1202 M L 0.328 Neutral MSH6 P52701 M1202N 1202 M N 0.096 Neutral MSH6 P52701 M1202P 1202 M P 0.852 Pathogenic MSH6 P52701 M1202Q 1202 M Q 0.018 Neutral MSH6 P52701 M1202R 1202 M R 0.08 Neutral MSH6 P52701 M1202S 1202 M S 0.032 Neutral MSH6 P52701 M1202T 1202 M T 0.022 Neutral MSH6 P52701 M1202V 1202 M V 0.502 Pathogenic MSH6 P52701 M1202W 1202 M W 0.926 Pathogenic MSH6 P52701 M1202Y 1202 M Y 0.832 Pathogenic MSH6 P52701 H1203A 1203 H A 0.364 Neutral MSH6 P52701 H1203C 1203 H C 0.102 Neutral MSH6 P52701 H1203D 1203 H D 0.032 Neutral MSH6 P52701 H1203E 1203 H E 0.008 Neutral MSH6 P52701 H1203F 1203 H F 0.734 Pathogenic MSH6 P52701 H1203G 1203 H G 0.13 Neutral MSH6 P52701 H1203I 1203 H I 0.77 Pathogenic MSH6 P52701 H1203K 1203 H K 0.598 Pathogenic MSH6 P52701 H1203L 1203 H L 0.628 Pathogenic MSH6 P52701 H1203M 1203 H M 0.524 Pathogenic MSH6 P52701 H1203N 1203 H N 0.016 Neutral MSH6 P52701 H1203P 1203 H P 0.906 Pathogenic MSH6 P52701 H1203Q 1203 H Q 0.156 Neutral MSH6 P52701 H1203R 1203 H R 0.17 Neutral MSH6 P52701 H1203S 1203 H S 0.028 Neutral MSH6 P52701 H1203T 1203 H T 0.458 Neutral MSH6 P52701 H1203V 1203 H V 0.518 Pathogenic MSH6 P52701 H1203W 1203 H W 0.948 Pathogenic MSH6 P52701 H1203Y 1203 H Y 0.108 Neutral MSH6 P52701 A1204C 1204 A C 0.52 Pathogenic MSH6 P52701 A1204D 1204 A D 0.892 Pathogenic MSH6 P52701 A1204E 1204 A E 0.838 Pathogenic MSH6 P52701 A1204F 1204 A F 0.944 Pathogenic MSH6 P52701 A1204G 1204 A G 0.168 Neutral MSH6 P52701 A1204H 1204 A H 0.836 Pathogenic MSH6 P52701 A1204I 1204 A I 0.878 Pathogenic MSH6 P52701 A1204K 1204 A K 0.912 Pathogenic MSH6 P52701 A1204L 1204 A L 0.956 Pathogenic MSH6 P52701 A1204M 1204 A M 0.73 Pathogenic MSH6 P52701 A1204N 1204 A N 0.81 Pathogenic MSH6 P52701 A1204P 1204 A P 0.952 Pathogenic MSH6 P52701 A1204Q 1204 A Q 0.768 Pathogenic MSH6 P52701 A1204R 1204 A R 0.942 Pathogenic MSH6 P52701 A1204S 1204 A S 0.102 Neutral MSH6 P52701 A1204T 1204 A T 0.228 Neutral MSH6 P52701 A1204V 1204 A V 0.772 Pathogenic MSH6 P52701 A1204W 1204 A W 0.954 Pathogenic MSH6 P52701 A1204Y 1204 A Y 0.95 Pathogenic MSH6 P52701 T1205A 1205 T A 0.694 Pathogenic MSH6 P52701 T1205C 1205 T C 0.922 Pathogenic MSH6 P52701 T1205D 1205 T D 0.93 Pathogenic MSH6 P52701 T1205E 1205 T E 0.934 Pathogenic MSH6 P52701 T1205F 1205 T F 0.948 Pathogenic MSH6 P52701 T1205G 1205 T G 0.206 Neutral MSH6 P52701 T1205H 1205 T H 0.916 Pathogenic MSH6 P52701 T1205I 1205 T I 0.944 Pathogenic MSH6 P52701 T1205K 1205 T K 0.934 Pathogenic MSH6 P52701 T1205L 1205 T L 0.94 Pathogenic MSH6 P52701 T1205M 1205 T M 0.974 Pathogenic MSH6 P52701 T1205N 1205 T N 0.87 Pathogenic MSH6 P52701 T1205P 1205 T P 0.956 Pathogenic MSH6 P52701 T1205Q 1205 T Q 0.874 Pathogenic MSH6 P52701 T1205R 1205 T R 0.994 Pathogenic MSH6 P52701 T1205S 1205 T S 0.172 Neutral MSH6 P52701 T1205V 1205 T V 0.79 Pathogenic MSH6 P52701 T1205W 1205 T W 0.952 Pathogenic MSH6 P52701 T1205Y 1205 T Y 0.952 Pathogenic MSH6 P52701 A1206C 1206 A C 0.14 Neutral MSH6 P52701 A1206D 1206 A D 0.854 Pathogenic MSH6 P52701 A1206E 1206 A E 0.534 Pathogenic MSH6 P52701 A1206F 1206 A F 0.886 Pathogenic MSH6 P52701 A1206G 1206 A G 0.556 Pathogenic MSH6 P52701 A1206H 1206 A H 0.79 Pathogenic MSH6 P52701 A1206I 1206 A I 0.918 Pathogenic MSH6 P52701 A1206K 1206 A K 0.504 Pathogenic MSH6 P52701 A1206L 1206 A L 0.896 Pathogenic MSH6 P52701 A1206M 1206 A M 0.76 Pathogenic MSH6 P52701 A1206N 1206 A N 0.538 Pathogenic MSH6 P52701 A1206P 1206 A P 0.112 Neutral MSH6 P52701 A1206Q 1206 A Q 0.476 Neutral MSH6 P52701 A1206R 1206 A R 0.552 Pathogenic MSH6 P52701 A1206S 1206 A S 0.026 Neutral MSH6 P52701 A1206T 1206 A T 0.254 Neutral MSH6 P52701 A1206V 1206 A V 0.194 Neutral MSH6 P52701 A1206W 1206 A W 0.904 Pathogenic MSH6 P52701 A1206Y 1206 A Y 0.896 Pathogenic MSH6 P52701 H1207A 1207 H A 0.176 Neutral MSH6 P52701 H1207C 1207 H C 0.296 Neutral MSH6 P52701 H1207D 1207 H D 0.018 Neutral MSH6 P52701 H1207E 1207 H E 0.122 Neutral MSH6 P52701 H1207F 1207 H F 0.38 Neutral MSH6 P52701 H1207G 1207 H G 0.32 Neutral MSH6 P52701 H1207I 1207 H I 0.762 Pathogenic MSH6 P52701 H1207K 1207 H K 0.044 Neutral MSH6 P52701 H1207L 1207 H L 0.702 Pathogenic MSH6 P52701 H1207M 1207 H M 0.604 Pathogenic MSH6 P52701 H1207N 1207 H N 0.014 Neutral MSH6 P52701 H1207P 1207 H P 0.9 Pathogenic MSH6 P52701 H1207Q 1207 H Q 0.406 Neutral MSH6 P52701 H1207R 1207 H R 0.014 Neutral MSH6 P52701 H1207S 1207 H S 0.364 Neutral MSH6 P52701 H1207T 1207 H T 0.448 Neutral MSH6 P52701 H1207V 1207 H V 0.506 Pathogenic MSH6 P52701 H1207W 1207 H W 0.94 Pathogenic MSH6 P52701 H1207Y 1207 H Y 0.124 Neutral MSH6 P52701 S1208A 1208 S A 0.87 Pathogenic MSH6 P52701 S1208C 1208 S C 0.904 Pathogenic MSH6 P52701 S1208D 1208 S D 0.912 Pathogenic MSH6 P52701 S1208E 1208 S E 0.962 Pathogenic MSH6 P52701 S1208F 1208 S F 0.982 Pathogenic MSH6 P52701 S1208G 1208 S G 0.696 Pathogenic MSH6 P52701 S1208H 1208 S H 0.974 Pathogenic MSH6 P52701 S1208I 1208 S I 0.886 Pathogenic MSH6 P52701 S1208K 1208 S K 0.954 Pathogenic MSH6 P52701 S1208L 1208 S L 0.926 Pathogenic MSH6 P52701 S1208M 1208 S M 0.998 Pathogenic MSH6 P52701 S1208N 1208 S N 0.892 Pathogenic MSH6 P52701 S1208P 1208 S P 0.97 Pathogenic MSH6 P52701 S1208Q 1208 S Q 0.952 Pathogenic MSH6 P52701 S1208R 1208 S R 0.972 Pathogenic MSH6 P52701 S1208T 1208 S T 0.712 Pathogenic MSH6 P52701 S1208V 1208 S V 0.954 Pathogenic MSH6 P52701 S1208W 1208 S W 0.954 Pathogenic MSH6 P52701 S1208Y 1208 S Y 0.962 Pathogenic MSH6 P52701 L1209A 1209 L A 0.702 Pathogenic MSH6 P52701 L1209C 1209 L C 0.806 Pathogenic MSH6 P52701 L1209D 1209 L D 0.884 Pathogenic MSH6 P52701 L1209E 1209 L E 0.866 Pathogenic MSH6 P52701 L1209F 1209 L F 0.498 Neutral MSH6 P52701 L1209G 1209 L G 0.858 Pathogenic MSH6 P52701 L1209H 1209 L H 0.898 Pathogenic MSH6 P52701 L1209I 1209 L I 0.396 Neutral MSH6 P52701 L1209K 1209 L K 0.69 Pathogenic MSH6 P52701 L1209M 1209 L M 0.262 Neutral MSH6 P52701 L1209N 1209 L N 0.796 Pathogenic MSH6 P52701 L1209P 1209 L P 0.966 Pathogenic MSH6 P52701 L1209Q 1209 L Q 0.756 Pathogenic MSH6 P52701 L1209R 1209 L R 0.974 Pathogenic MSH6 P52701 L1209S 1209 L S 0.68 Pathogenic MSH6 P52701 L1209T 1209 L T 0.598 Pathogenic MSH6 P52701 L1209V 1209 L V 0.176 Neutral MSH6 P52701 L1209W 1209 L W 0.846 Pathogenic MSH6 P52701 L1209Y 1209 L Y 0.868 Pathogenic MSH6 P52701 R121A 121 R A 0.15 Neutral MSH6 P52701 R121C 121 R C 0.25 Neutral MSH6 P52701 R121D 121 R D 0.266 Neutral MSH6 P52701 R121E 121 R E 0.208 Neutral MSH6 P52701 R121F 121 R F 0.46 Neutral MSH6 P52701 R121G 121 R G 0.106 Neutral MSH6 P52701 R121H 121 R H 0.192 Neutral MSH6 P52701 R121I 121 R I 0.482 Neutral MSH6 P52701 R121K 121 R K 0.01 Neutral MSH6 P52701 R121L 121 R L 0.444 Neutral MSH6 P52701 R121M 121 R M 0.262 Neutral MSH6 P52701 R121N 121 R N 0.258 Neutral MSH6 P52701 R121P 121 R P 0.424 Neutral MSH6 P52701 R121Q 121 R Q 0.238 Neutral MSH6 P52701 R121S 121 R S 0.21 Neutral MSH6 P52701 R121T 121 R T 0.216 Neutral MSH6 P52701 R121V 121 R V 0.314 Neutral MSH6 P52701 R121W 121 R W 0.632 Pathogenic MSH6 P52701 R121Y 121 R Y 0.46 Neutral MSH6 P52701 V1210A 1210 V A 0.244 Neutral MSH6 P52701 V1210C 1210 V C 0.802 Pathogenic MSH6 P52701 V1210D 1210 V D 0.858 Pathogenic MSH6 P52701 V1210E 1210 V E 0.96 Pathogenic MSH6 P52701 V1210F 1210 V F 0.928 Pathogenic MSH6 P52701 V1210G 1210 V G 0.93 Pathogenic MSH6 P52701 V1210H 1210 V H 0.91 Pathogenic MSH6 P52701 V1210I 1210 V I 0.89 Pathogenic MSH6 P52701 V1210K 1210 V K 0.978 Pathogenic MSH6 P52701 V1210L 1210 V L 0.35 Neutral MSH6 P52701 V1210M 1210 V M 0.914 Pathogenic MSH6 P52701 V1210N 1210 V N 0.914 Pathogenic MSH6 P52701 V1210P 1210 V P 0.982 Pathogenic MSH6 P52701 V1210Q 1210 V Q 0.966 Pathogenic MSH6 P52701 V1210R 1210 V R 0.952 Pathogenic MSH6 P52701 V1210S 1210 V S 0.802 Pathogenic MSH6 P52701 V1210T 1210 V T 0.874 Pathogenic MSH6 P52701 V1210W 1210 V W 0.952 Pathogenic MSH6 P52701 V1210Y 1210 V Y 0.972 Pathogenic MSH6 P52701 L1211A 1211 L A 0.09 Neutral MSH6 P52701 L1211C 1211 L C 0.692 Pathogenic MSH6 P52701 L1211D 1211 L D 0.912 Pathogenic MSH6 P52701 L1211E 1211 L E 0.892 Pathogenic MSH6 P52701 L1211F 1211 L F 0.952 Pathogenic MSH6 P52701 L1211G 1211 L G 0.81 Pathogenic MSH6 P52701 L1211H 1211 L H 0.792 Pathogenic MSH6 P52701 L1211I 1211 L I 0.11 Neutral MSH6 P52701 L1211K 1211 L K 0.732 Pathogenic MSH6 P52701 L1211M 1211 L M 0.734 Pathogenic MSH6 P52701 L1211N 1211 L N 0.784 Pathogenic MSH6 P52701 L1211P 1211 L P 0.988 Pathogenic MSH6 P52701 L1211Q 1211 L Q 0.62 Pathogenic MSH6 P52701 L1211R 1211 L R 0.996 Pathogenic MSH6 P52701 L1211S 1211 L S 0.608 Pathogenic MSH6 P52701 L1211T 1211 L T 0.328 Neutral MSH6 P52701 L1211V 1211 L V 0.078 Neutral MSH6 P52701 L1211W 1211 L W 0.922 Pathogenic MSH6 P52701 L1211Y 1211 L Y 0.88 Pathogenic MSH6 P52701 V1212A 1212 V A 0.328 Neutral MSH6 P52701 V1212C 1212 V C 0.71 Pathogenic MSH6 P52701 V1212D 1212 V D 0.862 Pathogenic MSH6 P52701 V1212E 1212 V E 0.978 Pathogenic MSH6 P52701 V1212F 1212 V F 0.876 Pathogenic MSH6 P52701 V1212G 1212 V G 0.894 Pathogenic MSH6 P52701 V1212H 1212 V H 0.82 Pathogenic MSH6 P52701 V1212I 1212 V I 0.184 Neutral MSH6 P52701 V1212K 1212 V K 0.99 Pathogenic MSH6 P52701 V1212L 1212 V L 0.168 Neutral MSH6 P52701 V1212M 1212 V M 0.212 Neutral MSH6 P52701 V1212N 1212 V N 0.922 Pathogenic MSH6 P52701 V1212P 1212 V P 0.984 Pathogenic MSH6 P52701 V1212Q 1212 V Q 0.984 Pathogenic MSH6 P52701 V1212R 1212 V R 0.952 Pathogenic MSH6 P52701 V1212S 1212 V S 0.72 Pathogenic MSH6 P52701 V1212T 1212 V T 0.746 Pathogenic MSH6 P52701 V1212W 1212 V W 0.904 Pathogenic MSH6 P52701 V1212Y 1212 V Y 0.928 Pathogenic MSH6 P52701 D1213A 1213 D A 0.79 Pathogenic MSH6 P52701 D1213C 1213 D C 0.878 Pathogenic MSH6 P52701 D1213E 1213 D E 0.804 Pathogenic MSH6 P52701 D1213F 1213 D F 0.98 Pathogenic MSH6 P52701 D1213G 1213 D G 0.932 Pathogenic MSH6 P52701 D1213H 1213 D H 0.62 Pathogenic MSH6 P52701 D1213I 1213 D I 0.974 Pathogenic MSH6 P52701 D1213K 1213 D K 0.918 Pathogenic MSH6 P52701 D1213L 1213 D L 0.976 Pathogenic MSH6 P52701 D1213M 1213 D M 0.956 Pathogenic MSH6 P52701 D1213N 1213 D N 0.852 Pathogenic MSH6 P52701 D1213P 1213 D P 0.9 Pathogenic MSH6 P52701 D1213Q 1213 D Q 0.612 Pathogenic MSH6 P52701 D1213R 1213 D R 0.958 Pathogenic MSH6 P52701 D1213S 1213 D S 0.562 Pathogenic MSH6 P52701 D1213T 1213 D T 0.794 Pathogenic MSH6 P52701 D1213V 1213 D V 0.996 Pathogenic MSH6 P52701 D1213W 1213 D W 0.98 Pathogenic MSH6 P52701 D1213Y 1213 D Y 0.972 Pathogenic MSH6 P52701 E1214A 1214 E A 0.81 Pathogenic MSH6 P52701 E1214C 1214 E C 0.764 Pathogenic MSH6 P52701 E1214D 1214 E D 0.894 Pathogenic MSH6 P52701 E1214F 1214 E F 0.96 Pathogenic MSH6 P52701 E1214G 1214 E G 0.314 Neutral MSH6 P52701 E1214H 1214 E H 0.744 Pathogenic MSH6 P52701 E1214I 1214 E I 0.984 Pathogenic MSH6 P52701 E1214K 1214 E K 0.914 Pathogenic MSH6 P52701 E1214L 1214 E L 0.974 Pathogenic MSH6 P52701 E1214M 1214 E M 0.91 Pathogenic MSH6 P52701 E1214N 1214 E N 0.782 Pathogenic MSH6 P52701 E1214P 1214 E P 0.938 Pathogenic MSH6 P52701 E1214Q 1214 E Q 0.854 Pathogenic MSH6 P52701 E1214R 1214 E R 0.934 Pathogenic MSH6 P52701 E1214S 1214 E S 0.892 Pathogenic MSH6 P52701 E1214T 1214 E T 0.84 Pathogenic MSH6 P52701 E1214V 1214 E V 0.922 Pathogenic MSH6 P52701 E1214W 1214 E W 0.978 Pathogenic MSH6 P52701 E1214Y 1214 E Y 0.958 Pathogenic MSH6 P52701 L1215A 1215 L A 0.712 Pathogenic MSH6 P52701 L1215C 1215 L C 0.822 Pathogenic MSH6 P52701 L1215D 1215 L D 0.91 Pathogenic MSH6 P52701 L1215E 1215 L E 0.894 Pathogenic MSH6 P52701 L1215F 1215 L F 0.876 Pathogenic MSH6 P52701 L1215G 1215 L G 0.862 Pathogenic MSH6 P52701 L1215H 1215 L H 0.908 Pathogenic MSH6 P52701 L1215I 1215 L I 0.938 Pathogenic MSH6 P52701 L1215K 1215 L K 0.716 Pathogenic MSH6 P52701 L1215M 1215 L M 0.606 Pathogenic MSH6 P52701 L1215N 1215 L N 0.82 Pathogenic MSH6 P52701 L1215P 1215 L P 0.994 Pathogenic MSH6 P52701 L1215Q 1215 L Q 0.774 Pathogenic MSH6 P52701 L1215R 1215 L R 0.984 Pathogenic MSH6 P52701 L1215S 1215 L S 0.694 Pathogenic MSH6 P52701 L1215T 1215 L T 0.618 Pathogenic MSH6 P52701 L1215V 1215 L V 0.43 Neutral MSH6 P52701 L1215W 1215 L W 0.878 Pathogenic MSH6 P52701 L1215Y 1215 L Y 0.886 Pathogenic MSH6 P52701 G1216A 1216 G A 0.966 Pathogenic MSH6 P52701 G1216C 1216 G C 0.946 Pathogenic MSH6 P52701 G1216D 1216 G D 0.998 Pathogenic MSH6 P52701 G1216E 1216 G E 0.986 Pathogenic MSH6 P52701 G1216F 1216 G F 0.982 Pathogenic MSH6 P52701 G1216H 1216 G H 0.986 Pathogenic MSH6 P52701 G1216I 1216 G I 0.974 Pathogenic MSH6 P52701 G1216K 1216 G K 0.986 Pathogenic MSH6 P52701 G1216L 1216 G L 0.984 Pathogenic MSH6 P52701 G1216M 1216 G M 0.994 Pathogenic MSH6 P52701 G1216N 1216 G N 0.986 Pathogenic MSH6 P52701 G1216P 1216 G P 0.964 Pathogenic MSH6 P52701 G1216Q 1216 G Q 0.994 Pathogenic MSH6 P52701 G1216R 1216 G R 1 Pathogenic MSH6 P52701 G1216S 1216 G S 0.824 Pathogenic MSH6 P52701 G1216T 1216 G T 0.84 Pathogenic MSH6 P52701 G1216V 1216 G V 0.986 Pathogenic MSH6 P52701 G1216W 1216 G W 0.978 Pathogenic MSH6 P52701 G1216Y 1216 G Y 0.958 Pathogenic MSH6 P52701 R1217A 1217 R A 0.572 Pathogenic MSH6 P52701 R1217C 1217 R C 0.954 Pathogenic MSH6 P52701 R1217D 1217 R D 0.688 Pathogenic MSH6 P52701 R1217E 1217 R E 0.794 Pathogenic MSH6 P52701 R1217F 1217 R F 0.976 Pathogenic MSH6 P52701 R1217G 1217 R G 0.396 Neutral MSH6 P52701 R1217H 1217 R H 0.382 Neutral MSH6 P52701 R1217I 1217 R I 0.976 Pathogenic MSH6 P52701 R1217K 1217 R K 0.75 Pathogenic MSH6 P52701 R1217L 1217 R L 0.768 Pathogenic MSH6 P52701 R1217M 1217 R M 0.784 Pathogenic MSH6 P52701 R1217N 1217 R N 0.646 Pathogenic MSH6 P52701 R1217P 1217 R P 0.988 Pathogenic MSH6 P52701 R1217Q 1217 R Q 0.502 Pathogenic MSH6 P52701 R1217S 1217 R S 0.516 Pathogenic MSH6 P52701 R1217T 1217 R T 0.94 Pathogenic MSH6 P52701 R1217V 1217 R V 0.976 Pathogenic MSH6 P52701 R1217W 1217 R W 0.958 Pathogenic MSH6 P52701 R1217Y 1217 R Y 0.966 Pathogenic MSH6 P52701 G1218A 1218 G A 0.966 Pathogenic MSH6 P52701 G1218C 1218 G C 0.946 Pathogenic MSH6 P52701 G1218D 1218 G D 0.998 Pathogenic MSH6 P52701 G1218E 1218 G E 0.986 Pathogenic MSH6 P52701 G1218F 1218 G F 0.982 Pathogenic MSH6 P52701 G1218H 1218 G H 0.986 Pathogenic MSH6 P52701 G1218I 1218 G I 0.974 Pathogenic MSH6 P52701 G1218K 1218 G K 0.986 Pathogenic MSH6 P52701 G1218L 1218 G L 0.984 Pathogenic MSH6 P52701 G1218M 1218 G M 0.994 Pathogenic MSH6 P52701 G1218N 1218 G N 0.986 Pathogenic MSH6 P52701 G1218P 1218 G P 0.964 Pathogenic MSH6 P52701 G1218Q 1218 G Q 0.994 Pathogenic MSH6 P52701 G1218R 1218 G R 1 Pathogenic MSH6 P52701 G1218S 1218 G S 0.824 Pathogenic MSH6 P52701 G1218T 1218 G T 0.84 Pathogenic MSH6 P52701 G1218V 1218 G V 0.986 Pathogenic MSH6 P52701 G1218W 1218 G W 0.978 Pathogenic MSH6 P52701 G1218Y 1218 G Y 0.958 Pathogenic MSH6 P52701 T1219A 1219 T A 0.714 Pathogenic MSH6 P52701 T1219C 1219 T C 0.942 Pathogenic MSH6 P52701 T1219D 1219 T D 0.954 Pathogenic MSH6 P52701 T1219E 1219 T E 0.952 Pathogenic MSH6 P52701 T1219F 1219 T F 0.95 Pathogenic MSH6 P52701 T1219G 1219 T G 0.746 Pathogenic MSH6 P52701 T1219H 1219 T H 0.924 Pathogenic MSH6 P52701 T1219I 1219 T I 0.952 Pathogenic MSH6 P52701 T1219K 1219 T K 0.94 Pathogenic MSH6 P52701 T1219L 1219 T L 0.952 Pathogenic MSH6 P52701 T1219M 1219 T M 0.984 Pathogenic MSH6 P52701 T1219N 1219 T N 0.898 Pathogenic MSH6 P52701 T1219P 1219 T P 0.968 Pathogenic MSH6 P52701 T1219Q 1219 T Q 0.894 Pathogenic MSH6 P52701 T1219R 1219 T R 0.994 Pathogenic MSH6 P52701 T1219S 1219 T S 0.83 Pathogenic MSH6 P52701 T1219V 1219 T V 0.842 Pathogenic MSH6 P52701 T1219W 1219 T W 0.976 Pathogenic MSH6 P52701 T1219Y 1219 T Y 0.976 Pathogenic MSH6 P52701 E122A 122 E A 0.122 Neutral MSH6 P52701 E122C 122 E C 0.068 Neutral MSH6 P52701 E122D 122 E D 0.082 Neutral MSH6 P52701 E122F 122 E F 0.272 Neutral MSH6 P52701 E122G 122 E G 0 Neutral MSH6 P52701 E122H 122 E H 0.162 Neutral MSH6 P52701 E122I 122 E I 0.284 Neutral MSH6 P52701 E122K 122 E K 0.002 Neutral MSH6 P52701 E122L 122 E L 0.138 Neutral MSH6 P52701 E122M 122 E M 0.164 Neutral MSH6 P52701 E122N 122 E N 0.036 Neutral MSH6 P52701 E122P 122 E P 0.3 Neutral MSH6 P52701 E122Q 122 E Q 0 Neutral MSH6 P52701 E122R 122 E R 0.046 Neutral MSH6 P52701 E122S 122 E S 0.168 Neutral MSH6 P52701 E122T 122 E T 0.14 Neutral MSH6 P52701 E122V 122 E V 0.232 Neutral MSH6 P52701 E122W 122 E W 0.43 Neutral MSH6 P52701 E122Y 122 E Y 0.338 Neutral MSH6 P52701 A1220C 1220 A C 0.978 Pathogenic MSH6 P52701 A1220D 1220 A D 0.958 Pathogenic MSH6 P52701 A1220E 1220 A E 0.976 Pathogenic MSH6 P52701 A1220F 1220 A F 0.996 Pathogenic MSH6 P52701 A1220G 1220 A G 0.77 Pathogenic MSH6 P52701 A1220H 1220 A H 0.942 Pathogenic MSH6 P52701 A1220I 1220 A I 0.968 Pathogenic MSH6 P52701 A1220K 1220 A K 0.976 Pathogenic MSH6 P52701 A1220L 1220 A L 1 Pathogenic MSH6 P52701 A1220M 1220 A M 0.91 Pathogenic MSH6 P52701 A1220N 1220 A N 0.878 Pathogenic MSH6 P52701 A1220P 1220 A P 0.978 Pathogenic MSH6 P52701 A1220Q 1220 A Q 0.894 Pathogenic MSH6 P52701 A1220R 1220 A R 0.978 Pathogenic MSH6 P52701 A1220S 1220 A S 0.226 Neutral MSH6 P52701 A1220T 1220 A T 0.884 Pathogenic MSH6 P52701 A1220V 1220 A V 0.942 Pathogenic MSH6 P52701 A1220W 1220 A W 0.996 Pathogenic MSH6 P52701 A1220Y 1220 A Y 0.972 Pathogenic MSH6 P52701 T1221A 1221 T A 0.698 Pathogenic MSH6 P52701 T1221C 1221 T C 0.93 Pathogenic MSH6 P52701 T1221D 1221 T D 0.944 Pathogenic MSH6 P52701 T1221E 1221 T E 0.948 Pathogenic MSH6 P52701 T1221F 1221 T F 0.948 Pathogenic MSH6 P52701 T1221G 1221 T G 0.73 Pathogenic MSH6 P52701 T1221H 1221 T H 0.914 Pathogenic MSH6 P52701 T1221I 1221 T I 0.95 Pathogenic MSH6 P52701 T1221K 1221 T K 0.938 Pathogenic MSH6 P52701 T1221L 1221 T L 0.948 Pathogenic MSH6 P52701 T1221M 1221 T M 0.984 Pathogenic MSH6 P52701 T1221N 1221 T N 0.88 Pathogenic MSH6 P52701 T1221P 1221 T P 0.958 Pathogenic MSH6 P52701 T1221Q 1221 T Q 0.876 Pathogenic MSH6 P52701 T1221R 1221 T R 0.99 Pathogenic MSH6 P52701 T1221S 1221 T S 0.15 Neutral MSH6 P52701 T1221V 1221 T V 0.89 Pathogenic MSH6 P52701 T1221W 1221 T W 0.988 Pathogenic MSH6 P52701 T1221Y 1221 T Y 0.988 Pathogenic MSH6 P52701 F1222A 1222 F A 0.406 Neutral MSH6 P52701 F1222C 1222 F C 0.548 Pathogenic MSH6 P52701 F1222D 1222 F D 0.818 Pathogenic MSH6 P52701 F1222E 1222 F E 0.92 Pathogenic MSH6 P52701 F1222G 1222 F G 0.5 Pathogenic MSH6 P52701 F1222H 1222 F H 0.092 Neutral MSH6 P52701 F1222I 1222 F I 0.51 Pathogenic MSH6 P52701 F1222K 1222 F K 0.88 Pathogenic MSH6 P52701 F1222L 1222 F L 0.49 Neutral MSH6 P52701 F1222M 1222 F M 0.61 Pathogenic MSH6 P52701 F1222N 1222 F N 0.49 Neutral MSH6 P52701 F1222P 1222 F P 0.866 Pathogenic MSH6 P52701 F1222Q 1222 F Q 0.788 Pathogenic MSH6 P52701 F1222R 1222 F R 0.21 Neutral MSH6 P52701 F1222S 1222 F S 0.176 Neutral MSH6 P52701 F1222T 1222 F T 0.528 Pathogenic MSH6 P52701 F1222V 1222 F V 0.684 Pathogenic MSH6 P52701 F1222W 1222 F W 0.794 Pathogenic MSH6 P52701 F1222Y 1222 F Y 0.378 Neutral MSH6 P52701 D1223A 1223 D A 0.79 Pathogenic MSH6 P52701 D1223C 1223 D C 0.878 Pathogenic MSH6 P52701 D1223E 1223 D E 0.804 Pathogenic MSH6 P52701 D1223F 1223 D F 0.98 Pathogenic MSH6 P52701 D1223G 1223 D G 0.932 Pathogenic MSH6 P52701 D1223H 1223 D H 0.62 Pathogenic MSH6 P52701 D1223I 1223 D I 0.974 Pathogenic MSH6 P52701 D1223K 1223 D K 0.918 Pathogenic MSH6 P52701 D1223L 1223 D L 0.976 Pathogenic MSH6 P52701 D1223M 1223 D M 0.956 Pathogenic MSH6 P52701 D1223N 1223 D N 0.852 Pathogenic MSH6 P52701 D1223P 1223 D P 0.9 Pathogenic MSH6 P52701 D1223Q 1223 D Q 0.612 Pathogenic MSH6 P52701 D1223R 1223 D R 0.958 Pathogenic MSH6 P52701 D1223S 1223 D S 0.562 Pathogenic MSH6 P52701 D1223T 1223 D T 0.794 Pathogenic MSH6 P52701 D1223V 1223 D V 0.996 Pathogenic MSH6 P52701 D1223W 1223 D W 0.98 Pathogenic MSH6 P52701 D1223Y 1223 D Y 0.972 Pathogenic MSH6 P52701 G1224A 1224 G A 0.966 Pathogenic MSH6 P52701 G1224C 1224 G C 0.946 Pathogenic MSH6 P52701 G1224D 1224 G D 0.998 Pathogenic MSH6 P52701 G1224E 1224 G E 0.986 Pathogenic MSH6 P52701 G1224F 1224 G F 0.98 Pathogenic MSH6 P52701 G1224H 1224 G H 0.984 Pathogenic MSH6 P52701 G1224I 1224 G I 0.972 Pathogenic MSH6 P52701 G1224K 1224 G K 0.984 Pathogenic MSH6 P52701 G1224L 1224 G L 0.982 Pathogenic MSH6 P52701 G1224M 1224 G M 0.994 Pathogenic MSH6 P52701 G1224N 1224 G N 0.986 Pathogenic MSH6 P52701 G1224P 1224 G P 0.962 Pathogenic MSH6 P52701 G1224Q 1224 G Q 0.994 Pathogenic MSH6 P52701 G1224R 1224 G R 1 Pathogenic MSH6 P52701 G1224S 1224 G S 0.824 Pathogenic MSH6 P52701 G1224T 1224 G T 0.838 Pathogenic MSH6 P52701 G1224V 1224 G V 0.984 Pathogenic MSH6 P52701 G1224W 1224 G W 0.976 Pathogenic MSH6 P52701 G1224Y 1224 G Y 0.956 Pathogenic MSH6 P52701 T1225A 1225 T A 0.276 Neutral MSH6 P52701 T1225C 1225 T C 0.356 Neutral MSH6 P52701 T1225D 1225 T D 0.612 Pathogenic MSH6 P52701 T1225E 1225 T E 0.706 Pathogenic MSH6 P52701 T1225F 1225 T F 0.79 Pathogenic MSH6 P52701 T1225G 1225 T G 0.338 Neutral MSH6 P52701 T1225H 1225 T H 0.264 Neutral MSH6 P52701 T1225I 1225 T I 0.648 Pathogenic MSH6 P52701 T1225K 1225 T K 0.634 Pathogenic MSH6 P52701 T1225L 1225 T L 0.446 Neutral MSH6 P52701 T1225M 1225 T M 0.368 Neutral MSH6 P52701 T1225N 1225 T N 0.034 Neutral MSH6 P52701 T1225P 1225 T P 0.706 Pathogenic MSH6 P52701 T1225Q 1225 T Q 0.036 Neutral MSH6 P52701 T1225R 1225 T R 0.87 Pathogenic MSH6 P52701 T1225S 1225 T S 0.014 Neutral MSH6 P52701 T1225V 1225 T V 0.05 Neutral MSH6 P52701 T1225W 1225 T W 0.94 Pathogenic MSH6 P52701 T1225Y 1225 T Y 0.586 Pathogenic MSH6 P52701 A1226C 1226 A C 0.806 Pathogenic MSH6 P52701 A1226D 1226 A D 0.896 Pathogenic MSH6 P52701 A1226E 1226 A E 0.842 Pathogenic MSH6 P52701 A1226F 1226 A F 0.94 Pathogenic MSH6 P52701 A1226G 1226 A G 0.708 Pathogenic MSH6 P52701 A1226H 1226 A H 0.834 Pathogenic MSH6 P52701 A1226I 1226 A I 0.94 Pathogenic MSH6 P52701 A1226K 1226 A K 0.908 Pathogenic MSH6 P52701 A1226L 1226 A L 0.952 Pathogenic MSH6 P52701 A1226M 1226 A M 0.82 Pathogenic MSH6 P52701 A1226N 1226 A N 0.828 Pathogenic MSH6 P52701 A1226P 1226 A P 0.95 Pathogenic MSH6 P52701 A1226Q 1226 A Q 0.782 Pathogenic MSH6 P52701 A1226R 1226 A R 0.942 Pathogenic MSH6 P52701 A1226S 1226 A S 0.09 Neutral MSH6 P52701 A1226T 1226 A T 0.676 Pathogenic MSH6 P52701 A1226V 1226 A V 0.884 Pathogenic MSH6 P52701 A1226W 1226 A W 0.95 Pathogenic MSH6 P52701 A1226Y 1226 A Y 0.946 Pathogenic MSH6 P52701 I1227A 1227 I A 0.534 Pathogenic MSH6 P52701 I1227C 1227 I C 0.65 Pathogenic MSH6 P52701 I1227D 1227 I D 0.74 Pathogenic MSH6 P52701 I1227E 1227 I E 0.746 Pathogenic MSH6 P52701 I1227F 1227 I F 0.958 Pathogenic MSH6 P52701 I1227G 1227 I G 0.804 Pathogenic MSH6 P52701 I1227H 1227 I H 0.892 Pathogenic MSH6 P52701 I1227K 1227 I K 0.842 Pathogenic MSH6 P52701 I1227L 1227 I L 0.112 Neutral MSH6 P52701 I1227M 1227 I M 0.708 Pathogenic MSH6 P52701 I1227N 1227 I N 0.764 Pathogenic MSH6 P52701 I1227P 1227 I P 0.928 Pathogenic MSH6 P52701 I1227Q 1227 I Q 0.778 Pathogenic MSH6 P52701 I1227R 1227 I R 0.864 Pathogenic MSH6 P52701 I1227S 1227 I S 0.646 Pathogenic MSH6 P52701 I1227T 1227 I T 0.346 Neutral MSH6 P52701 I1227V 1227 I V 0.118 Neutral MSH6 P52701 I1227W 1227 I W 0.99 Pathogenic MSH6 P52701 I1227Y 1227 I Y 0.978 Pathogenic MSH6 P52701 A1228C 1228 A C 0.862 Pathogenic MSH6 P52701 A1228D 1228 A D 0.926 Pathogenic MSH6 P52701 A1228E 1228 A E 0.758 Pathogenic MSH6 P52701 A1228F 1228 A F 0.968 Pathogenic MSH6 P52701 A1228G 1228 A G 0.756 Pathogenic MSH6 P52701 A1228H 1228 A H 0.868 Pathogenic MSH6 P52701 A1228I 1228 A I 0.96 Pathogenic MSH6 P52701 A1228K 1228 A K 0.938 Pathogenic MSH6 P52701 A1228L 1228 A L 0.982 Pathogenic MSH6 P52701 A1228M 1228 A M 0.854 Pathogenic MSH6 P52701 A1228N 1228 A N 0.862 Pathogenic MSH6 P52701 A1228P 1228 A P 0.968 Pathogenic MSH6 P52701 A1228Q 1228 A Q 0.818 Pathogenic MSH6 P52701 A1228R 1228 A R 0.958 Pathogenic MSH6 P52701 A1228S 1228 A S 0.428 Neutral MSH6 P52701 A1228T 1228 A T 0.734 Pathogenic MSH6 P52701 A1228V 1228 A V 0.87 Pathogenic MSH6 P52701 A1228W 1228 A W 0.978 Pathogenic MSH6 P52701 A1228Y 1228 A Y 0.964 Pathogenic MSH6 P52701 N1229A 1229 N A 0.046 Neutral MSH6 P52701 N1229C 1229 N C 0.046 Neutral MSH6 P52701 N1229D 1229 N D 0.582 Pathogenic MSH6 P52701 N1229E 1229 N E 0.03 Neutral MSH6 P52701 N1229F 1229 N F 0.892 Pathogenic MSH6 P52701 N1229G 1229 N G 0.056 Neutral MSH6 P52701 N1229H 1229 N H 0.048 Neutral MSH6 P52701 N1229I 1229 N I 0.8 Pathogenic MSH6 P52701 N1229K 1229 N K 0.73 Pathogenic MSH6 P52701 N1229L 1229 N L 0.818 Pathogenic MSH6 P52701 N1229M 1229 N M 0.76 Pathogenic MSH6 P52701 N1229P 1229 N P 0.7 Pathogenic MSH6 P52701 N1229Q 1229 N Q 0.026 Neutral MSH6 P52701 N1229R 1229 N R 0.616 Pathogenic MSH6 P52701 N1229S 1229 N S 0.024 Neutral MSH6 P52701 N1229T 1229 N T 0.034 Neutral MSH6 P52701 N1229V 1229 N V 0.838 Pathogenic MSH6 P52701 N1229W 1229 N W 0.914 Pathogenic MSH6 P52701 N1229Y 1229 N Y 0.654 Pathogenic MSH6 P52701 K123A 123 K A 0.054 Neutral MSH6 P52701 K123C 123 K C 0.028 Neutral MSH6 P52701 K123D 123 K D 0.066 Neutral MSH6 P52701 K123E 123 K E 0.004 Neutral MSH6 P52701 K123F 123 K F 0.22 Neutral MSH6 P52701 K123G 123 K G 0.116 Neutral MSH6 P52701 K123H 123 K H 0.018 Neutral MSH6 P52701 K123I 123 K I 0.2 Neutral MSH6 P52701 K123L 123 K L 0.222 Neutral MSH6 P52701 K123M 123 K M 0.112 Neutral MSH6 P52701 K123N 123 K N 0.082 Neutral MSH6 P52701 K123P 123 K P 0.224 Neutral MSH6 P52701 K123Q 123 K Q 0.048 Neutral MSH6 P52701 K123R 123 K R 0.002 Neutral MSH6 P52701 K123S 123 K S 0.176 Neutral MSH6 P52701 K123T 123 K T 0.182 Neutral MSH6 P52701 K123V 123 K V 0.186 Neutral MSH6 P52701 K123W 123 K W 0.414 Neutral MSH6 P52701 K123Y 123 K Y 0.344 Neutral MSH6 P52701 A1230C 1230 A C 0.978 Pathogenic MSH6 P52701 A1230D 1230 A D 0.958 Pathogenic MSH6 P52701 A1230E 1230 A E 0.976 Pathogenic MSH6 P52701 A1230F 1230 A F 0.996 Pathogenic MSH6 P52701 A1230G 1230 A G 0.184 Neutral MSH6 P52701 A1230H 1230 A H 0.942 Pathogenic MSH6 P52701 A1230I 1230 A I 0.968 Pathogenic MSH6 P52701 A1230K 1230 A K 0.976 Pathogenic MSH6 P52701 A1230L 1230 A L 1 Pathogenic MSH6 P52701 A1230M 1230 A M 0.91 Pathogenic MSH6 P52701 A1230N 1230 A N 0.878 Pathogenic MSH6 P52701 A1230P 1230 A P 0.978 Pathogenic MSH6 P52701 A1230Q 1230 A Q 0.894 Pathogenic MSH6 P52701 A1230R 1230 A R 0.978 Pathogenic MSH6 P52701 A1230S 1230 A S 0.138 Neutral MSH6 P52701 A1230T 1230 A T 0.412 Neutral MSH6 P52701 A1230V 1230 A V 0.942 Pathogenic MSH6 P52701 A1230W 1230 A W 0.996 Pathogenic MSH6 P52701 A1230Y 1230 A Y 0.972 Pathogenic MSH6 P52701 V1231A 1231 V A 0.282 Neutral MSH6 P52701 V1231C 1231 V C 0.802 Pathogenic MSH6 P52701 V1231D 1231 V D 0.858 Pathogenic MSH6 P52701 V1231E 1231 V E 0.96 Pathogenic MSH6 P52701 V1231F 1231 V F 0.928 Pathogenic MSH6 P52701 V1231G 1231 V G 0.93 Pathogenic MSH6 P52701 V1231H 1231 V H 0.91 Pathogenic MSH6 P52701 V1231I 1231 V I 0.544 Pathogenic MSH6 P52701 V1231K 1231 V K 0.978 Pathogenic MSH6 P52701 V1231L 1231 V L 0.94 Pathogenic MSH6 P52701 V1231M 1231 V M 0.914 Pathogenic MSH6 P52701 V1231N 1231 V N 0.914 Pathogenic MSH6 P52701 V1231P 1231 V P 0.982 Pathogenic MSH6 P52701 V1231Q 1231 V Q 0.966 Pathogenic MSH6 P52701 V1231R 1231 V R 0.952 Pathogenic MSH6 P52701 V1231S 1231 V S 0.802 Pathogenic MSH6 P52701 V1231T 1231 V T 0.264 Neutral MSH6 P52701 V1231W 1231 V W 0.952 Pathogenic MSH6 P52701 V1231Y 1231 V Y 0.658 Pathogenic MSH6 P52701 V1232A 1232 V A 0.168 Neutral MSH6 P52701 V1232C 1232 V C 0.4 Neutral MSH6 P52701 V1232D 1232 V D 0.852 Pathogenic MSH6 P52701 V1232E 1232 V E 0.966 Pathogenic MSH6 P52701 V1232F 1232 V F 0.674 Pathogenic MSH6 P52701 V1232G 1232 V G 0.888 Pathogenic MSH6 P52701 V1232H 1232 V H 0.864 Pathogenic MSH6 P52701 V1232I 1232 V I 0.5 Pathogenic MSH6 P52701 V1232K 1232 V K 0.984 Pathogenic MSH6 P52701 V1232L 1232 V L 0.226 Neutral MSH6 P52701 V1232M 1232 V M 0.87 Pathogenic MSH6 P52701 V1232N 1232 V N 0.914 Pathogenic MSH6 P52701 V1232P 1232 V P 0.972 Pathogenic MSH6 P52701 V1232Q 1232 V Q 0.974 Pathogenic MSH6 P52701 V1232R 1232 V R 0.95 Pathogenic MSH6 P52701 V1232S 1232 V S 0.764 Pathogenic MSH6 P52701 V1232T 1232 V T 0.834 Pathogenic MSH6 P52701 V1232W 1232 V W 0.924 Pathogenic MSH6 P52701 V1232Y 1232 V Y 0.952 Pathogenic MSH6 P52701 K1233A 1233 K A 0.246 Neutral MSH6 P52701 K1233C 1233 K C 0.14 Neutral MSH6 P52701 K1233D 1233 K D 0.034 Neutral MSH6 P52701 K1233E 1233 K E 0.032 Neutral MSH6 P52701 K1233F 1233 K F 0.804 Pathogenic MSH6 P52701 K1233G 1233 K G 0.332 Neutral MSH6 P52701 K1233H 1233 K H 0.026 Neutral MSH6 P52701 K1233I 1233 K I 0.854 Pathogenic MSH6 P52701 K1233L 1233 K L 0.446 Neutral MSH6 P52701 K1233M 1233 K M 0.608 Pathogenic MSH6 P52701 K1233N 1233 K N 0.042 Neutral MSH6 P52701 K1233P 1233 K P 0.8 Pathogenic MSH6 P52701 K1233Q 1233 K Q 0.05 Neutral MSH6 P52701 K1233R 1233 K R 0.048 Neutral MSH6 P52701 K1233S 1233 K S 0.044 Neutral MSH6 P52701 K1233T 1233 K T 0.41 Neutral MSH6 P52701 K1233V 1233 K V 0.746 Pathogenic MSH6 P52701 K1233W 1233 K W 0.976 Pathogenic MSH6 P52701 K1233Y 1233 K Y 0.92 Pathogenic MSH6 P52701 E1234A 1234 E A 0.22 Neutral MSH6 P52701 E1234C 1234 E C 0.488 Neutral MSH6 P52701 E1234D 1234 E D 0.046 Neutral MSH6 P52701 E1234F 1234 E F 0.122 Neutral MSH6 P52701 E1234G 1234 E G 0.208 Neutral MSH6 P52701 E1234H 1234 E H 0.096 Neutral MSH6 P52701 E1234I 1234 E I 0.936 Pathogenic MSH6 P52701 E1234K 1234 E K 0.044 Neutral MSH6 P52701 E1234L 1234 E L 0.918 Pathogenic MSH6 P52701 E1234M 1234 E M 0.724 Pathogenic MSH6 P52701 E1234N 1234 E N 0.02 Neutral MSH6 P52701 E1234P 1234 E P 0.89 Pathogenic MSH6 P52701 E1234Q 1234 E Q 0.362 Neutral MSH6 P52701 E1234R 1234 E R 0.414 Neutral MSH6 P52701 E1234S 1234 E S 0.53 Pathogenic MSH6 P52701 E1234T 1234 E T 0.536 Pathogenic MSH6 P52701 E1234V 1234 E V 0.848 Pathogenic MSH6 P52701 E1234W 1234 E W 0.972 Pathogenic MSH6 P52701 E1234Y 1234 E Y 0.354 Neutral MSH6 P52701 L1235A 1235 L A 0.564 Pathogenic MSH6 P52701 L1235C 1235 L C 0.684 Pathogenic MSH6 P52701 L1235D 1235 L D 0.898 Pathogenic MSH6 P52701 L1235E 1235 L E 0.878 Pathogenic MSH6 P52701 L1235F 1235 L F 0.444 Neutral MSH6 P52701 L1235G 1235 L G 0.8 Pathogenic MSH6 P52701 L1235H 1235 L H 0.8 Pathogenic MSH6 P52701 L1235I 1235 L I 0.14 Neutral MSH6 P52701 L1235K 1235 L K 0.742 Pathogenic MSH6 P52701 L1235M 1235 L M 0.454 Neutral MSH6 P52701 L1235N 1235 L N 0.768 Pathogenic MSH6 P52701 L1235P 1235 L P 0.994 Pathogenic MSH6 P52701 L1235Q 1235 L Q 0.616 Pathogenic MSH6 P52701 L1235R 1235 L R 0.996 Pathogenic MSH6 P52701 L1235S 1235 L S 0.608 Pathogenic MSH6 P52701 L1235T 1235 L T 0.586 Pathogenic MSH6 P52701 L1235V 1235 L V 0.072 Neutral MSH6 P52701 L1235W 1235 L W 0.934 Pathogenic MSH6 P52701 L1235Y 1235 L Y 0.894 Pathogenic MSH6 P52701 A1236C 1236 A C 0.248 Neutral MSH6 P52701 A1236D 1236 A D 0.802 Pathogenic MSH6 P52701 A1236E 1236 A E 0.828 Pathogenic MSH6 P52701 A1236F 1236 A F 0.922 Pathogenic MSH6 P52701 A1236G 1236 A G 0.454 Neutral MSH6 P52701 A1236H 1236 A H 0.816 Pathogenic MSH6 P52701 A1236I 1236 A I 0.636 Pathogenic MSH6 P52701 A1236K 1236 A K 0.862 Pathogenic MSH6 P52701 A1236L 1236 A L 0.612 Pathogenic MSH6 P52701 A1236M 1236 A M 0.758 Pathogenic MSH6 P52701 A1236N 1236 A N 0.734 Pathogenic MSH6 P52701 A1236P 1236 A P 0.866 Pathogenic MSH6 P52701 A1236Q 1236 A Q 0.758 Pathogenic MSH6 P52701 A1236R 1236 A R 0.87 Pathogenic MSH6 P52701 A1236S 1236 A S 0.016 Neutral MSH6 P52701 A1236T 1236 A T 0.046 Neutral MSH6 P52701 A1236V 1236 A V 0.18 Neutral MSH6 P52701 A1236W 1236 A W 0.92 Pathogenic MSH6 P52701 A1236Y 1236 A Y 0.904 Pathogenic MSH6 P52701 E1237A 1237 E A 0.55 Pathogenic MSH6 P52701 E1237C 1237 E C 0.386 Neutral MSH6 P52701 E1237D 1237 E D 0.016 Neutral MSH6 P52701 E1237F 1237 E F 0.782 Pathogenic MSH6 P52701 E1237G 1237 E G 0.302 Neutral MSH6 P52701 E1237H 1237 E H 0.034 Neutral MSH6 P52701 E1237I 1237 E I 0.836 Pathogenic MSH6 P52701 E1237K 1237 E K 0.028 Neutral MSH6 P52701 E1237L 1237 E L 0.822 Pathogenic MSH6 P52701 E1237M 1237 E M 0.636 Pathogenic MSH6 P52701 E1237N 1237 E N 0.018 Neutral MSH6 P52701 E1237P 1237 E P 0.84 Pathogenic MSH6 P52701 E1237Q 1237 E Q 0.016 Neutral MSH6 P52701 E1237R 1237 E R 0.076 Neutral MSH6 P52701 E1237S 1237 E S 0.038 Neutral MSH6 P52701 E1237T 1237 E T 0.04 Neutral MSH6 P52701 E1237V 1237 E V 0.792 Pathogenic MSH6 P52701 E1237W 1237 E W 0.918 Pathogenic MSH6 P52701 E1237Y 1237 E Y 0.88 Pathogenic MSH6 P52701 T1238A 1238 T A 0.324 Neutral MSH6 P52701 T1238C 1238 T C 0.342 Neutral MSH6 P52701 T1238D 1238 T D 0.07 Neutral MSH6 P52701 T1238E 1238 T E 0.098 Neutral MSH6 P52701 T1238F 1238 T F 0.618 Pathogenic MSH6 P52701 T1238G 1238 T G 0.068 Neutral MSH6 P52701 T1238H 1238 T H 0.136 Neutral MSH6 P52701 T1238I 1238 T I 0.38 Neutral MSH6 P52701 T1238K 1238 T K 0.036 Neutral MSH6 P52701 T1238L 1238 T L 0.408 Neutral MSH6 P52701 T1238M 1238 T M 0.524 Pathogenic MSH6 P52701 T1238N 1238 T N 0.008 Neutral MSH6 P52701 T1238P 1238 T P 0.29 Neutral MSH6 P52701 T1238Q 1238 T Q 0.044 Neutral MSH6 P52701 T1238R 1238 T R 0.378 Neutral MSH6 P52701 T1238S 1238 T S 0.008 Neutral MSH6 P52701 T1238V 1238 T V 0.334 Neutral MSH6 P52701 T1238W 1238 T W 0.878 Pathogenic MSH6 P52701 T1238Y 1238 T Y 0.872 Pathogenic MSH6 P52701 I1239A 1239 I A 0.15 Neutral MSH6 P52701 I1239C 1239 I C 0.27 Neutral MSH6 P52701 I1239D 1239 I D 0.612 Pathogenic MSH6 P52701 I1239E 1239 I E 0.6 Pathogenic MSH6 P52701 I1239F 1239 I F 0.672 Pathogenic MSH6 P52701 I1239G 1239 I G 0.588 Pathogenic MSH6 P52701 I1239H 1239 I H 0.512 Pathogenic MSH6 P52701 I1239K 1239 I K 0.21 Neutral MSH6 P52701 I1239L 1239 I L 0.002 Neutral MSH6 P52701 I1239M 1239 I M 0.062 Neutral MSH6 P52701 I1239N 1239 I N 0.184 Neutral MSH6 P52701 I1239P 1239 I P 0.716 Pathogenic MSH6 P52701 I1239Q 1239 I Q 0.636 Pathogenic MSH6 P52701 I1239R 1239 I R 0.814 Pathogenic MSH6 P52701 I1239S 1239 I S 0.09 Neutral MSH6 P52701 I1239T 1239 I T 0.316 Neutral MSH6 P52701 I1239V 1239 I V 0.002 Neutral MSH6 P52701 I1239W 1239 I W 0.858 Pathogenic MSH6 P52701 I1239Y 1239 I Y 0.85 Pathogenic MSH6 P52701 G124A 124 G A 0.082 Neutral MSH6 P52701 G124C 124 G C 0.354 Neutral MSH6 P52701 G124D 124 G D 0.424 Neutral MSH6 P52701 G124E 124 G E 0.562 Pathogenic MSH6 P52701 G124F 124 G F 0.756 Pathogenic MSH6 P52701 G124H 124 G H 0.698 Pathogenic MSH6 P52701 G124I 124 G I 0.676 Pathogenic MSH6 P52701 G124K 124 G K 0.412 Neutral MSH6 P52701 G124L 124 G L 0.676 Pathogenic MSH6 P52701 G124M 124 G M 0.688 Pathogenic MSH6 P52701 G124N 124 G N 0.324 Neutral MSH6 P52701 G124P 124 G P 0.684 Pathogenic MSH6 P52701 G124Q 124 G Q 0.452 Neutral MSH6 P52701 G124R 124 G R 0.424 Neutral MSH6 P52701 G124S 124 G S 0.29 Neutral MSH6 P52701 G124T 124 G T 0.468 Neutral MSH6 P52701 G124V 124 G V 0.654 Pathogenic MSH6 P52701 G124W 124 G W 0.754 Pathogenic MSH6 P52701 G124Y 124 G Y 0.738 Pathogenic MSH6 P52701 K1240A 1240 K A 0.104 Neutral MSH6 P52701 K1240C 1240 K C 0.014 Neutral MSH6 P52701 K1240D 1240 K D 0.256 Neutral MSH6 P52701 K1240E 1240 K E 0.296 Neutral MSH6 P52701 K1240F 1240 K F 0.822 Pathogenic MSH6 P52701 K1240G 1240 K G 0.096 Neutral MSH6 P52701 K1240H 1240 K H 0.012 Neutral MSH6 P52701 K1240I 1240 K I 0.754 Pathogenic MSH6 P52701 K1240L 1240 K L 0.822 Pathogenic MSH6 P52701 K1240M 1240 K M 0.584 Pathogenic MSH6 P52701 K1240N 1240 K N 0.028 Neutral MSH6 P52701 K1240P 1240 K P 0.81 Pathogenic MSH6 P52701 K1240Q 1240 K Q 0.022 Neutral MSH6 P52701 K1240R 1240 K R 0.026 Neutral MSH6 P52701 K1240S 1240 K S 0.04 Neutral MSH6 P52701 K1240T 1240 K T 0.268 Neutral MSH6 P52701 K1240V 1240 K V 0.674 Pathogenic MSH6 P52701 K1240W 1240 K W 0.976 Pathogenic MSH6 P52701 K1240Y 1240 K Y 0.924 Pathogenic MSH6 P52701 C1241A 1241 C A 0.166 Neutral MSH6 P52701 C1241D 1241 C D 0.95 Pathogenic MSH6 P52701 C1241E 1241 C E 0.878 Pathogenic MSH6 P52701 C1241F 1241 C F 0.986 Pathogenic MSH6 P52701 C1241G 1241 C G 0.934 Pathogenic MSH6 P52701 C1241H 1241 C H 0.854 Pathogenic MSH6 P52701 C1241I 1241 C I 0.958 Pathogenic MSH6 P52701 C1241K 1241 C K 0.888 Pathogenic MSH6 P52701 C1241L 1241 C L 0.986 Pathogenic MSH6 P52701 C1241M 1241 C M 0.776 Pathogenic MSH6 P52701 C1241N 1241 C N 0.812 Pathogenic MSH6 P52701 C1241P 1241 C P 0.33 Neutral MSH6 P52701 C1241Q 1241 C Q 0.676 Pathogenic MSH6 P52701 C1241R 1241 C R 0.998 Pathogenic MSH6 P52701 C1241S 1241 C S 0.09 Neutral MSH6 P52701 C1241T 1241 C T 0.742 Pathogenic MSH6 P52701 C1241V 1241 C V 0.688 Pathogenic MSH6 P52701 C1241W 1241 C W 0.99 Pathogenic MSH6 P52701 C1241Y 1241 C Y 0.982 Pathogenic MSH6 P52701 R1242A 1242 R A 0.52 Pathogenic MSH6 P52701 R1242C 1242 R C 0.436 Neutral MSH6 P52701 R1242D 1242 R D 0.86 Pathogenic MSH6 P52701 R1242E 1242 R E 0.824 Pathogenic MSH6 P52701 R1242F 1242 R F 0.972 Pathogenic MSH6 P52701 R1242G 1242 R G 0.404 Neutral MSH6 P52701 R1242H 1242 R H 0.57 Pathogenic MSH6 P52701 R1242I 1242 R I 0.432 Neutral MSH6 P52701 R1242K 1242 R K 0.844 Pathogenic MSH6 P52701 R1242L 1242 R L 0.354 Neutral MSH6 P52701 R1242M 1242 R M 0.232 Neutral MSH6 P52701 R1242N 1242 R N 0.752 Pathogenic MSH6 P52701 R1242P 1242 R P 0.984 Pathogenic MSH6 P52701 R1242Q 1242 R Q 0.622 Pathogenic MSH6 P52701 R1242S 1242 R S 0.85 Pathogenic MSH6 P52701 R1242T 1242 R T 0.382 Neutral MSH6 P52701 R1242V 1242 R V 0.332 Neutral MSH6 P52701 R1242W 1242 R W 0.968 Pathogenic MSH6 P52701 R1242Y 1242 R Y 0.97 Pathogenic MSH6 P52701 T1243A 1243 T A 0.148 Neutral MSH6 P52701 T1243C 1243 T C 0.182 Neutral MSH6 P52701 T1243D 1243 T D 0.822 Pathogenic MSH6 P52701 T1243E 1243 T E 0.888 Pathogenic MSH6 P52701 T1243F 1243 T F 0.908 Pathogenic MSH6 P52701 T1243G 1243 T G 0.092 Neutral MSH6 P52701 T1243H 1243 T H 0.834 Pathogenic MSH6 P52701 T1243I 1243 T I 0.872 Pathogenic MSH6 P52701 T1243K 1243 T K 0.848 Pathogenic MSH6 P52701 T1243L 1243 T L 0.4 Neutral MSH6 P52701 T1243M 1243 T M 0.944 Pathogenic MSH6 P52701 T1243N 1243 T N 0.742 Pathogenic MSH6 P52701 T1243P 1243 T P 0.9 Pathogenic MSH6 P52701 T1243Q 1243 T Q 0.75 Pathogenic MSH6 P52701 T1243R 1243 T R 0.954 Pathogenic MSH6 P52701 T1243S 1243 T S 0.08 Neutral MSH6 P52701 T1243V 1243 T V 0.856 Pathogenic MSH6 P52701 T1243W 1243 T W 0.982 Pathogenic MSH6 P52701 T1243Y 1243 T Y 0.982 Pathogenic MSH6 P52701 L1244A 1244 L A 0.546 Pathogenic MSH6 P52701 L1244C 1244 L C 0.65 Pathogenic MSH6 P52701 L1244D 1244 L D 0.906 Pathogenic MSH6 P52701 L1244E 1244 L E 0.874 Pathogenic MSH6 P52701 L1244F 1244 L F 0.428 Neutral MSH6 P52701 L1244G 1244 L G 0.808 Pathogenic MSH6 P52701 L1244H 1244 L H 0.728 Pathogenic MSH6 P52701 L1244I 1244 L I 0.132 Neutral MSH6 P52701 L1244K 1244 L K 0.656 Pathogenic MSH6 P52701 L1244M 1244 L M 0.16 Neutral MSH6 P52701 L1244N 1244 L N 0.78 Pathogenic MSH6 P52701 L1244P 1244 L P 0.942 Pathogenic MSH6 P52701 L1244Q 1244 L Q 0.578 Pathogenic MSH6 P52701 L1244R 1244 L R 0.982 Pathogenic MSH6 P52701 L1244S 1244 L S 0.552 Pathogenic MSH6 P52701 L1244T 1244 L T 0.51 Pathogenic MSH6 P52701 L1244V 1244 L V 0.162 Neutral MSH6 P52701 L1244W 1244 L W 0.83 Pathogenic MSH6 P52701 L1244Y 1244 L Y 0.646 Pathogenic MSH6 P52701 F1245A 1245 F A 0.498 Neutral MSH6 P52701 F1245C 1245 F C 0.728 Pathogenic MSH6 P52701 F1245D 1245 F D 0.816 Pathogenic MSH6 P52701 F1245E 1245 F E 0.87 Pathogenic MSH6 P52701 F1245G 1245 F G 0.506 Pathogenic MSH6 P52701 F1245H 1245 F H 0.772 Pathogenic MSH6 P52701 F1245I 1245 F I 0.688 Pathogenic MSH6 P52701 F1245K 1245 F K 0.85 Pathogenic MSH6 P52701 F1245L 1245 F L 0.704 Pathogenic MSH6 P52701 F1245M 1245 F M 0.788 Pathogenic MSH6 P52701 F1245N 1245 F N 0.766 Pathogenic MSH6 P52701 F1245P 1245 F P 0.952 Pathogenic MSH6 P52701 F1245Q 1245 F Q 0.788 Pathogenic MSH6 P52701 F1245R 1245 F R 0.918 Pathogenic MSH6 P52701 F1245S 1245 F S 0.868 Pathogenic MSH6 P52701 F1245T 1245 F T 0.59 Pathogenic MSH6 P52701 F1245V 1245 F V 0.746 Pathogenic MSH6 P52701 F1245W 1245 F W 0.868 Pathogenic MSH6 P52701 F1245Y 1245 F Y 0.572 Pathogenic MSH6 P52701 S1246A 1246 S A 0.2 Neutral MSH6 P52701 S1246C 1246 S C 0.896 Pathogenic MSH6 P52701 S1246D 1246 S D 0.898 Pathogenic MSH6 P52701 S1246E 1246 S E 0.954 Pathogenic MSH6 P52701 S1246F 1246 S F 0.982 Pathogenic MSH6 P52701 S1246G 1246 S G 0.68 Pathogenic MSH6 P52701 S1246H 1246 S H 0.972 Pathogenic MSH6 P52701 S1246I 1246 S I 0.886 Pathogenic MSH6 P52701 S1246K 1246 S K 0.952 Pathogenic MSH6 P52701 S1246L 1246 S L 0.926 Pathogenic MSH6 P52701 S1246M 1246 S M 0.998 Pathogenic MSH6 P52701 S1246N 1246 S N 0.88 Pathogenic MSH6 P52701 S1246P 1246 S P 0.968 Pathogenic MSH6 P52701 S1246Q 1246 S Q 0.944 Pathogenic MSH6 P52701 S1246R 1246 S R 0.97 Pathogenic MSH6 P52701 S1246T 1246 S T 0.88 Pathogenic MSH6 P52701 S1246V 1246 S V 0.97 Pathogenic MSH6 P52701 S1246W 1246 S W 0.982 Pathogenic MSH6 P52701 S1246Y 1246 S Y 0.98 Pathogenic MSH6 P52701 T1247A 1247 T A 0.714 Pathogenic MSH6 P52701 T1247C 1247 T C 0.942 Pathogenic MSH6 P52701 T1247D 1247 T D 0.954 Pathogenic MSH6 P52701 T1247E 1247 T E 0.952 Pathogenic MSH6 P52701 T1247F 1247 T F 0.95 Pathogenic MSH6 P52701 T1247G 1247 T G 0.746 Pathogenic MSH6 P52701 T1247H 1247 T H 0.924 Pathogenic MSH6 P52701 T1247I 1247 T I 0.952 Pathogenic MSH6 P52701 T1247K 1247 T K 0.94 Pathogenic MSH6 P52701 T1247L 1247 T L 0.952 Pathogenic MSH6 P52701 T1247M 1247 T M 0.984 Pathogenic MSH6 P52701 T1247N 1247 T N 0.898 Pathogenic MSH6 P52701 T1247P 1247 T P 0.968 Pathogenic MSH6 P52701 T1247Q 1247 T Q 0.894 Pathogenic MSH6 P52701 T1247R 1247 T R 0.994 Pathogenic MSH6 P52701 T1247S 1247 T S 0.42 Neutral MSH6 P52701 T1247V 1247 T V 0.842 Pathogenic MSH6 P52701 T1247W 1247 T W 0.976 Pathogenic MSH6 P52701 T1247Y 1247 T Y 0.976 Pathogenic MSH6 P52701 H1248A 1248 H A 0.716 Pathogenic MSH6 P52701 H1248C 1248 H C 0.696 Pathogenic MSH6 P52701 H1248D 1248 H D 0.642 Pathogenic MSH6 P52701 H1248E 1248 H E 0.818 Pathogenic MSH6 P52701 H1248F 1248 H F 0.9 Pathogenic MSH6 P52701 H1248G 1248 H G 0.508 Pathogenic MSH6 P52701 H1248I 1248 H I 0.894 Pathogenic MSH6 P52701 H1248K 1248 H K 0.68 Pathogenic MSH6 P52701 H1248L 1248 H L 0.74 Pathogenic MSH6 P52701 H1248M 1248 H M 0.646 Pathogenic MSH6 P52701 H1248N 1248 H N 0.636 Pathogenic MSH6 P52701 H1248P 1248 H P 0.984 Pathogenic MSH6 P52701 H1248Q 1248 H Q 0.83 Pathogenic MSH6 P52701 H1248R 1248 H R 0.91 Pathogenic MSH6 P52701 H1248S 1248 H S 0.652 Pathogenic MSH6 P52701 H1248T 1248 H T 0.56 Pathogenic MSH6 P52701 H1248V 1248 H V 0.7 Pathogenic MSH6 P52701 H1248W 1248 H W 0.962 Pathogenic MSH6 P52701 H1248Y 1248 H Y 0.91 Pathogenic MSH6 P52701 Y1249A 1249 Y A 0.442 Neutral MSH6 P52701 Y1249C 1249 Y C 0.696 Pathogenic MSH6 P52701 Y1249D 1249 Y D 0.854 Pathogenic MSH6 P52701 Y1249E 1249 Y E 0.762 Pathogenic MSH6 P52701 Y1249F 1249 Y F 0.506 Pathogenic MSH6 P52701 Y1249G 1249 Y G 0.488 Neutral MSH6 P52701 Y1249H 1249 Y H 0.614 Pathogenic MSH6 P52701 Y1249I 1249 Y I 0.806 Pathogenic MSH6 P52701 Y1249K 1249 Y K 0.828 Pathogenic MSH6 P52701 Y1249L 1249 Y L 0.714 Pathogenic MSH6 P52701 Y1249M 1249 Y M 0.694 Pathogenic MSH6 P52701 Y1249N 1249 Y N 0.752 Pathogenic MSH6 P52701 Y1249P 1249 Y P 0.79 Pathogenic MSH6 P52701 Y1249Q 1249 Y Q 0.67 Pathogenic MSH6 P52701 Y1249R 1249 Y R 0.792 Pathogenic MSH6 P52701 Y1249S 1249 Y S 0.488 Neutral MSH6 P52701 Y1249T 1249 Y T 0.692 Pathogenic MSH6 P52701 Y1249V 1249 Y V 0.672 Pathogenic MSH6 P52701 Y1249W 1249 Y W 0.914 Pathogenic MSH6 P52701 K125A 125 K A 0.054 Neutral MSH6 P52701 K125C 125 K C 0.028 Neutral MSH6 P52701 K125D 125 K D 0.05 Neutral MSH6 P52701 K125E 125 K E 0.052 Neutral MSH6 P52701 K125F 125 K F 0.226 Neutral MSH6 P52701 K125G 125 K G 0.132 Neutral MSH6 P52701 K125H 125 K H 0.048 Neutral MSH6 P52701 K125I 125 K I 0.24 Neutral MSH6 P52701 K125L 125 K L 0.166 Neutral MSH6 P52701 K125M 125 K M 0.112 Neutral MSH6 P52701 K125N 125 K N 0.046 Neutral MSH6 P52701 K125P 125 K P 0.248 Neutral MSH6 P52701 K125Q 125 K Q 0.048 Neutral MSH6 P52701 K125R 125 K R 0.002 Neutral MSH6 P52701 K125S 125 K S 0.09 Neutral MSH6 P52701 K125T 125 K T 0.09 Neutral MSH6 P52701 K125V 125 K V 0.192 Neutral MSH6 P52701 K125W 125 K W 0.442 Neutral MSH6 P52701 K125Y 125 K Y 0.362 Neutral MSH6 P52701 H1250A 1250 H A 0.702 Pathogenic MSH6 P52701 H1250C 1250 H C 0.672 Pathogenic MSH6 P52701 H1250D 1250 H D 0.6 Pathogenic MSH6 P52701 H1250E 1250 H E 0.788 Pathogenic MSH6 P52701 H1250F 1250 H F 0.862 Pathogenic MSH6 P52701 H1250G 1250 H G 0.318 Neutral MSH6 P52701 H1250I 1250 H I 0.866 Pathogenic MSH6 P52701 H1250K 1250 H K 0.426 Neutral MSH6 P52701 H1250L 1250 H L 0.678 Pathogenic MSH6 P52701 H1250M 1250 H M 0.57 Pathogenic MSH6 P52701 H1250N 1250 H N 0.288 Neutral MSH6 P52701 H1250P 1250 H P 0.97 Pathogenic MSH6 P52701 H1250Q 1250 H Q 0.206 Neutral MSH6 P52701 H1250R 1250 H R 0.25 Neutral MSH6 P52701 H1250S 1250 H S 0.604 Pathogenic MSH6 P52701 H1250T 1250 H T 0.478 Neutral MSH6 P52701 H1250V 1250 H V 0.65 Pathogenic MSH6 P52701 H1250W 1250 H W 0.938 Pathogenic MSH6 P52701 H1250Y 1250 H Y 0.58 Pathogenic MSH6 P52701 S1251A 1251 S A 0.652 Pathogenic MSH6 P52701 S1251C 1251 S C 0.656 Pathogenic MSH6 P52701 S1251D 1251 S D 0.434 Neutral MSH6 P52701 S1251E 1251 S E 0.836 Pathogenic MSH6 P52701 S1251F 1251 S F 0.808 Pathogenic MSH6 P52701 S1251G 1251 S G 0.102 Neutral MSH6 P52701 S1251H 1251 S H 0.544 Pathogenic MSH6 P52701 S1251I 1251 S I 0.694 Pathogenic MSH6 P52701 S1251K 1251 S K 0.518 Pathogenic MSH6 P52701 S1251L 1251 S L 0.782 Pathogenic MSH6 P52701 S1251M 1251 S M 0.658 Pathogenic MSH6 P52701 S1251N 1251 S N 0.156 Neutral MSH6 P52701 S1251P 1251 S P 0.816 Pathogenic MSH6 P52701 S1251Q 1251 S Q 0.562 Pathogenic MSH6 P52701 S1251R 1251 S R 0.526 Pathogenic MSH6 P52701 S1251T 1251 S T 0.254 Neutral MSH6 P52701 S1251V 1251 S V 0.8 Pathogenic MSH6 P52701 S1251W 1251 S W 0.888 Pathogenic MSH6 P52701 S1251Y 1251 S Y 0.888 Pathogenic MSH6 P52701 L1252A 1252 L A 0.718 Pathogenic MSH6 P52701 L1252C 1252 L C 0.824 Pathogenic MSH6 P52701 L1252D 1252 L D 0.908 Pathogenic MSH6 P52701 L1252E 1252 L E 0.89 Pathogenic MSH6 P52701 L1252F 1252 L F 0.87 Pathogenic MSH6 P52701 L1252G 1252 L G 0.872 Pathogenic MSH6 P52701 L1252H 1252 L H 0.91 Pathogenic MSH6 P52701 L1252I 1252 L I 0.428 Neutral MSH6 P52701 L1252K 1252 L K 0.72 Pathogenic MSH6 P52701 L1252M 1252 L M 0.6 Pathogenic MSH6 P52701 L1252N 1252 L N 0.818 Pathogenic MSH6 P52701 L1252P 1252 L P 0.986 Pathogenic MSH6 P52701 L1252Q 1252 L Q 0.772 Pathogenic MSH6 P52701 L1252R 1252 L R 0.986 Pathogenic MSH6 P52701 L1252S 1252 L S 0.708 Pathogenic MSH6 P52701 L1252T 1252 L T 0.624 Pathogenic MSH6 P52701 L1252V 1252 L V 0.41 Neutral MSH6 P52701 L1252W 1252 L W 0.874 Pathogenic MSH6 P52701 L1252Y 1252 L Y 0.886 Pathogenic MSH6 P52701 V1253A 1253 V A 0.014 Neutral MSH6 P52701 V1253C 1253 V C 0.034 Neutral MSH6 P52701 V1253D 1253 V D 0.62 Pathogenic MSH6 P52701 V1253E 1253 V E 0.722 Pathogenic MSH6 P52701 V1253F 1253 V F 0.622 Pathogenic MSH6 P52701 V1253G 1253 V G 0.638 Pathogenic MSH6 P52701 V1253H 1253 V H 0.554 Pathogenic MSH6 P52701 V1253I 1253 V I 0.064 Neutral MSH6 P52701 V1253K 1253 V K 0.804 Pathogenic MSH6 P52701 V1253L 1253 V L 0.072 Neutral MSH6 P52701 V1253M 1253 V M 0.264 Neutral MSH6 P52701 V1253N 1253 V N 0.66 Pathogenic MSH6 P52701 V1253P 1253 V P 0.868 Pathogenic MSH6 P52701 V1253Q 1253 V Q 0.736 Pathogenic MSH6 P52701 V1253R 1253 V R 0.842 Pathogenic MSH6 P52701 V1253S 1253 V S 0.04 Neutral MSH6 P52701 V1253T 1253 V T 0.03 Neutral MSH6 P52701 V1253W 1253 V W 0.848 Pathogenic MSH6 P52701 V1253Y 1253 V Y 0.84 Pathogenic MSH6 P52701 E1254A 1254 E A 0.182 Neutral MSH6 P52701 E1254C 1254 E C 0.414 Neutral MSH6 P52701 E1254D 1254 E D 0.01 Neutral MSH6 P52701 E1254F 1254 E F 0.796 Pathogenic MSH6 P52701 E1254G 1254 E G 0.13 Neutral MSH6 P52701 E1254H 1254 E H 0.652 Pathogenic MSH6 P52701 E1254I 1254 E I 0.208 Neutral MSH6 P52701 E1254K 1254 E K 0.036 Neutral MSH6 P52701 E1254L 1254 E L 0.248 Neutral MSH6 P52701 E1254M 1254 E M 0.17 Neutral MSH6 P52701 E1254N 1254 E N 0.012 Neutral MSH6 P52701 E1254P 1254 E P 0.858 Pathogenic MSH6 P52701 E1254Q 1254 E Q 0.012 Neutral MSH6 P52701 E1254R 1254 E R 0.098 Neutral MSH6 P52701 E1254S 1254 E S 0.04 Neutral MSH6 P52701 E1254T 1254 E T 0.028 Neutral MSH6 P52701 E1254V 1254 E V 0.082 Neutral MSH6 P52701 E1254W 1254 E W 0.934 Pathogenic MSH6 P52701 E1254Y 1254 E Y 0.886 Pathogenic MSH6 P52701 D1255A 1255 D A 0.126 Neutral MSH6 P52701 D1255C 1255 D C 0.75 Pathogenic MSH6 P52701 D1255E 1255 D E 0.078 Neutral MSH6 P52701 D1255F 1255 D F 0.294 Neutral MSH6 P52701 D1255G 1255 D G 0.354 Neutral MSH6 P52701 D1255H 1255 D H 0.154 Neutral MSH6 P52701 D1255I 1255 D I 0.912 Pathogenic MSH6 P52701 D1255K 1255 D K 0.712 Pathogenic MSH6 P52701 D1255L 1255 D L 0.776 Pathogenic MSH6 P52701 D1255M 1255 D M 0.818 Pathogenic MSH6 P52701 D1255N 1255 D N 0.016 Neutral MSH6 P52701 D1255P 1255 D P 0.82 Pathogenic MSH6 P52701 D1255Q 1255 D Q 0.052 Neutral MSH6 P52701 D1255R 1255 D R 0.574 Pathogenic MSH6 P52701 D1255S 1255 D S 0.01 Neutral MSH6 P52701 D1255T 1255 D T 0.272 Neutral MSH6 P52701 D1255V 1255 D V 0.504 Pathogenic MSH6 P52701 D1255W 1255 D W 0.97 Pathogenic MSH6 P52701 D1255Y 1255 D Y 0.698 Pathogenic MSH6 P52701 Y1256A 1256 Y A 0.122 Neutral MSH6 P52701 Y1256C 1256 Y C 0.35 Neutral MSH6 P52701 Y1256D 1256 Y D 0.574 Pathogenic MSH6 P52701 Y1256E 1256 Y E 0.562 Pathogenic MSH6 P52701 Y1256F 1256 Y F 0.074 Neutral MSH6 P52701 Y1256G 1256 Y G 0.28 Neutral MSH6 P52701 Y1256H 1256 Y H 0.026 Neutral MSH6 P52701 Y1256I 1256 Y I 0.252 Neutral MSH6 P52701 Y1256K 1256 Y K 0.396 Neutral MSH6 P52701 Y1256L 1256 Y L 0.052 Neutral MSH6 P52701 Y1256M 1256 Y M 0.346 Neutral MSH6 P52701 Y1256N 1256 Y N 0.406 Neutral MSH6 P52701 Y1256P 1256 Y P 0.136 Neutral MSH6 P52701 Y1256Q 1256 Y Q 0.372 Neutral MSH6 P52701 Y1256R 1256 Y R 0.602 Pathogenic MSH6 P52701 Y1256S 1256 Y S 0.284 Neutral MSH6 P52701 Y1256T 1256 Y T 0.356 Neutral MSH6 P52701 Y1256V 1256 Y V 0.032 Neutral MSH6 P52701 Y1256W 1256 Y W 0.07 Neutral MSH6 P52701 S1257A 1257 S A 0.012 Neutral MSH6 P52701 S1257C 1257 S C 0.09 Neutral MSH6 P52701 S1257D 1257 S D 0.028 Neutral MSH6 P52701 S1257E 1257 S E 0.3 Neutral MSH6 P52701 S1257F 1257 S F 0.58 Pathogenic MSH6 P52701 S1257G 1257 S G 0.134 Neutral MSH6 P52701 S1257H 1257 S H 0.34 Neutral MSH6 P52701 S1257I 1257 S I 0.228 Neutral MSH6 P52701 S1257K 1257 S K 0.314 Neutral MSH6 P52701 S1257L 1257 S L 0.06 Neutral MSH6 P52701 S1257M 1257 S M 0.664 Pathogenic MSH6 P52701 S1257N 1257 S N 0.008 Neutral MSH6 P52701 S1257P 1257 S P 0.236 Neutral MSH6 P52701 S1257Q 1257 S Q 0.332 Neutral MSH6 P52701 S1257R 1257 S R 0.324 Neutral MSH6 P52701 S1257T 1257 S T 0.024 Neutral MSH6 P52701 S1257V 1257 S V 0.048 Neutral MSH6 P52701 S1257W 1257 S W 0.812 Pathogenic MSH6 P52701 S1257Y 1257 S Y 0.774 Pathogenic MSH6 P52701 Q1258A 1258 Q A 0.054 Neutral MSH6 P52701 Q1258C 1258 Q C 0.164 Neutral MSH6 P52701 Q1258D 1258 Q D 0 Neutral MSH6 P52701 Q1258E 1258 Q E 0.012 Neutral MSH6 P52701 Q1258F 1258 Q F 0.266 Neutral MSH6 P52701 Q1258G 1258 Q G 0.048 Neutral MSH6 P52701 Q1258H 1258 Q H 0.032 Neutral MSH6 P52701 Q1258I 1258 Q I 0.304 Neutral MSH6 P52701 Q1258K 1258 Q K 0.024 Neutral MSH6 P52701 Q1258L 1258 Q L 0.4 Neutral MSH6 P52701 Q1258M 1258 Q M 0.032 Neutral MSH6 P52701 Q1258N 1258 Q N 0.028 Neutral MSH6 P52701 Q1258P 1258 Q P 0.474 Neutral MSH6 P52701 Q1258R 1258 Q R 0.006 Neutral MSH6 P52701 Q1258S 1258 Q S 0.05 Neutral MSH6 P52701 Q1258T 1258 Q T 0.006 Neutral MSH6 P52701 Q1258V 1258 Q V 0.034 Neutral MSH6 P52701 Q1258W 1258 Q W 0.692 Pathogenic MSH6 P52701 Q1258Y 1258 Q Y 0.712 Pathogenic MSH6 P52701 N1259A 1259 N A 0.14 Neutral MSH6 P52701 N1259C 1259 N C 0.108 Neutral MSH6 P52701 N1259D 1259 N D 0.008 Neutral MSH6 P52701 N1259E 1259 N E 0.128 Neutral MSH6 P52701 N1259F 1259 N F 0.496 Neutral MSH6 P52701 N1259G 1259 N G 0.188 Neutral MSH6 P52701 N1259H 1259 N H 0.078 Neutral MSH6 P52701 N1259I 1259 N I 0.354 Neutral MSH6 P52701 N1259K 1259 N K 0.046 Neutral MSH6 P52701 N1259L 1259 N L 0.354 Neutral MSH6 P52701 N1259M 1259 N M 0.294 Neutral MSH6 P52701 N1259P 1259 N P 0.316 Neutral MSH6 P52701 N1259Q 1259 N Q 0.184 Neutral MSH6 P52701 N1259R 1259 N R 0.258 Neutral MSH6 P52701 N1259S 1259 N S 0.002 Neutral MSH6 P52701 N1259T 1259 N T 0.164 Neutral MSH6 P52701 N1259V 1259 N V 0.328 Neutral MSH6 P52701 N1259W 1259 N W 0.628 Pathogenic MSH6 P52701 N1259Y 1259 N Y 0.622 Pathogenic MSH6 P52701 S126A 126 S A 0.018 Neutral MSH6 P52701 S126C 126 S C 0.022 Neutral MSH6 P52701 S126D 126 S D 0.004 Neutral MSH6 P52701 S126E 126 S E 0.148 Neutral MSH6 P52701 S126F 126 S F 0.276 Neutral MSH6 P52701 S126G 126 S G 0.036 Neutral MSH6 P52701 S126H 126 S H 0.238 Neutral MSH6 P52701 S126I 126 S I 0.17 Neutral MSH6 P52701 S126K 126 S K 0.14 Neutral MSH6 P52701 S126L 126 S L 0.028 Neutral MSH6 P52701 S126M 126 S M 0.332 Neutral MSH6 P52701 S126N 126 S N 0.012 Neutral MSH6 P52701 S126P 126 S P 0.116 Neutral MSH6 P52701 S126Q 126 S Q 0.158 Neutral MSH6 P52701 S126R 126 S R 0.248 Neutral MSH6 P52701 S126T 126 S T 0.02 Neutral MSH6 P52701 S126V 126 S V 0.134 Neutral MSH6 P52701 S126W 126 S W 0.49 Neutral MSH6 P52701 S126Y 126 S Y 0.434 Neutral MSH6 P52701 V1260A 1260 V A 0.034 Neutral MSH6 P52701 V1260C 1260 V C 0.288 Neutral MSH6 P52701 V1260D 1260 V D 0.06 Neutral MSH6 P52701 V1260E 1260 V E 0.106 Neutral MSH6 P52701 V1260F 1260 V F 0.68 Pathogenic MSH6 P52701 V1260G 1260 V G 0.154 Neutral MSH6 P52701 V1260H 1260 V H 0.178 Neutral MSH6 P52701 V1260I 1260 V I 0.408 Neutral MSH6 P52701 V1260K 1260 V K 0.138 Neutral MSH6 P52701 V1260L 1260 V L 0.376 Neutral MSH6 P52701 V1260M 1260 V M 0.374 Neutral MSH6 P52701 V1260N 1260 V N 0.286 Neutral MSH6 P52701 V1260P 1260 V P 0.196 Neutral MSH6 P52701 V1260Q 1260 V Q 0.112 Neutral MSH6 P52701 V1260R 1260 V R 0.502 Pathogenic MSH6 P52701 V1260S 1260 V S 0.052 Neutral MSH6 P52701 V1260T 1260 V T 0.07 Neutral MSH6 P52701 V1260W 1260 V W 0.778 Pathogenic MSH6 P52701 V1260Y 1260 V Y 0.654 Pathogenic MSH6 P52701 A1261C 1261 A C 0.414 Neutral MSH6 P52701 A1261D 1261 A D 0.6 Pathogenic MSH6 P52701 A1261E 1261 A E 0.526 Pathogenic MSH6 P52701 A1261F 1261 A F 0.886 Pathogenic MSH6 P52701 A1261G 1261 A G 0.05 Neutral MSH6 P52701 A1261H 1261 A H 0.478 Neutral MSH6 P52701 A1261I 1261 A I 0.918 Pathogenic MSH6 P52701 A1261K 1261 A K 0.5 Pathogenic MSH6 P52701 A1261L 1261 A L 0.704 Pathogenic MSH6 P52701 A1261M 1261 A M 0.758 Pathogenic MSH6 P52701 A1261N 1261 A N 0.536 Pathogenic MSH6 P52701 A1261P 1261 A P 0.78 Pathogenic MSH6 P52701 A1261Q 1261 A Q 0.478 Neutral MSH6 P52701 A1261R 1261 A R 0.552 Pathogenic MSH6 P52701 A1261S 1261 A S 0.036 Neutral MSH6 P52701 A1261T 1261 A T 0.26 Neutral MSH6 P52701 A1261V 1261 A V 0.66 Pathogenic MSH6 P52701 A1261W 1261 A W 0.904 Pathogenic MSH6 P52701 A1261Y 1261 A Y 0.896 Pathogenic MSH6 P52701 V1262A 1262 V A 0.326 Neutral MSH6 P52701 V1262C 1262 V C 0.37 Neutral MSH6 P52701 V1262D 1262 V D 0.86 Pathogenic MSH6 P52701 V1262E 1262 V E 0.586 Pathogenic MSH6 P52701 V1262F 1262 V F 0.89 Pathogenic MSH6 P52701 V1262G 1262 V G 0.884 Pathogenic MSH6 P52701 V1262H 1262 V H 0.834 Pathogenic MSH6 P52701 V1262I 1262 V I 0.158 Neutral MSH6 P52701 V1262K 1262 V K 0.986 Pathogenic MSH6 P52701 V1262L 1262 V L 0.268 Neutral MSH6 P52701 V1262M 1262 V M 0.834 Pathogenic MSH6 P52701 V1262N 1262 V N 0.918 Pathogenic MSH6 P52701 V1262P 1262 V P 0.976 Pathogenic MSH6 P52701 V1262Q 1262 V Q 0.982 Pathogenic MSH6 P52701 V1262R 1262 V R 0.954 Pathogenic MSH6 P52701 V1262S 1262 V S 0.722 Pathogenic MSH6 P52701 V1262T 1262 V T 0.766 Pathogenic MSH6 P52701 V1262W 1262 V W 0.918 Pathogenic MSH6 P52701 V1262Y 1262 V Y 0.946 Pathogenic MSH6 P52701 R1263A 1263 R A 0.086 Neutral MSH6 P52701 R1263C 1263 R C 0.064 Neutral MSH6 P52701 R1263D 1263 R D 0.054 Neutral MSH6 P52701 R1263E 1263 R E 0.116 Neutral MSH6 P52701 R1263F 1263 R F 0.858 Pathogenic MSH6 P52701 R1263G 1263 R G 0.046 Neutral MSH6 P52701 R1263H 1263 R H 0.538 Pathogenic MSH6 P52701 R1263I 1263 R I 0.838 Pathogenic MSH6 P52701 R1263K 1263 R K 0.038 Neutral MSH6 P52701 R1263L 1263 R L 0.138 Neutral MSH6 P52701 R1263M 1263 R M 0.626 Pathogenic MSH6 P52701 R1263N 1263 R N 0.552 Pathogenic MSH6 P52701 R1263P 1263 R P 0.796 Pathogenic MSH6 P52701 R1263Q 1263 R Q 0.018 Neutral MSH6 P52701 R1263S 1263 R S 0.036 Neutral MSH6 P52701 R1263T 1263 R T 0.04 Neutral MSH6 P52701 R1263V 1263 R V 0.418 Neutral MSH6 P52701 R1263W 1263 R W 0.856 Pathogenic MSH6 P52701 R1263Y 1263 R Y 0.478 Neutral MSH6 P52701 L1264A 1264 L A 0.102 Neutral MSH6 P52701 L1264C 1264 L C 0.642 Pathogenic MSH6 P52701 L1264D 1264 L D 0.894 Pathogenic MSH6 P52701 L1264E 1264 L E 0.498 Neutral MSH6 P52701 L1264F 1264 L F 0.586 Pathogenic MSH6 P52701 L1264G 1264 L G 0.804 Pathogenic MSH6 P52701 L1264H 1264 L H 0.71 Pathogenic MSH6 P52701 L1264I 1264 L I 0.142 Neutral MSH6 P52701 L1264K 1264 L K 0.396 Neutral MSH6 P52701 L1264M 1264 L M 0.176 Neutral MSH6 P52701 L1264N 1264 L N 0.166 Neutral MSH6 P52701 L1264P 1264 L P 0.254 Neutral MSH6 P52701 L1264Q 1264 L Q 0.564 Pathogenic MSH6 P52701 L1264R 1264 L R 0.97 Pathogenic MSH6 P52701 L1264S 1264 L S 0.354 Neutral MSH6 P52701 L1264T 1264 L T 0.108 Neutral MSH6 P52701 L1264V 1264 L V 0.304 Neutral MSH6 P52701 L1264W 1264 L W 0.79 Pathogenic MSH6 P52701 L1264Y 1264 L Y 0.748 Pathogenic MSH6 P52701 G1265A 1265 G A 0.064 Neutral MSH6 P52701 G1265C 1265 G C 0.516 Pathogenic MSH6 P52701 G1265D 1265 G D 0.832 Pathogenic MSH6 P52701 G1265E 1265 G E 0.964 Pathogenic MSH6 P52701 G1265F 1265 G F 0.976 Pathogenic MSH6 P52701 G1265H 1265 G H 0.936 Pathogenic MSH6 P52701 G1265I 1265 G I 0.962 Pathogenic MSH6 P52701 G1265K 1265 G K 0.596 Pathogenic MSH6 P52701 G1265L 1265 G L 0.97 Pathogenic MSH6 P52701 G1265M 1265 G M 0.596 Pathogenic MSH6 P52701 G1265N 1265 G N 0.648 Pathogenic MSH6 P52701 G1265P 1265 G P 0.934 Pathogenic MSH6 P52701 G1265Q 1265 G Q 0.646 Pathogenic MSH6 P52701 G1265R 1265 G R 0.6 Pathogenic MSH6 P52701 G1265S 1265 G S 0.116 Neutral MSH6 P52701 G1265T 1265 G T 0.85 Pathogenic MSH6 P52701 G1265V 1265 G V 0.976 Pathogenic MSH6 P52701 G1265W 1265 G W 0.964 Pathogenic MSH6 P52701 G1265Y 1265 G Y 0.792 Pathogenic MSH6 P52701 H1266A 1266 H A 0.632 Pathogenic MSH6 P52701 H1266C 1266 H C 0.578 Pathogenic MSH6 P52701 H1266D 1266 H D 0.52 Pathogenic MSH6 P52701 H1266E 1266 H E 0.714 Pathogenic MSH6 P52701 H1266F 1266 H F 0.896 Pathogenic MSH6 P52701 H1266G 1266 H G 0.486 Neutral MSH6 P52701 H1266I 1266 H I 0.89 Pathogenic MSH6 P52701 H1266K 1266 H K 0.774 Pathogenic MSH6 P52701 H1266L 1266 H L 0.81 Pathogenic MSH6 P52701 H1266M 1266 H M 0.764 Pathogenic MSH6 P52701 H1266N 1266 H N 0.522 Pathogenic MSH6 P52701 H1266P 1266 H P 0.966 Pathogenic MSH6 P52701 H1266Q 1266 H Q 0.156 Neutral MSH6 P52701 H1266R 1266 H R 0.166 Neutral MSH6 P52701 H1266S 1266 H S 0.708 Pathogenic MSH6 P52701 H1266T 1266 H T 0.654 Pathogenic MSH6 P52701 H1266V 1266 H V 0.698 Pathogenic MSH6 P52701 H1266W 1266 H W 0.982 Pathogenic MSH6 P52701 H1266Y 1266 H Y 0.462 Neutral MSH6 P52701 M1267A 1267 M A 0.686 Pathogenic MSH6 P52701 M1267C 1267 M C 0.62 Pathogenic MSH6 P52701 M1267D 1267 M D 0.88 Pathogenic MSH6 P52701 M1267E 1267 M E 0.816 Pathogenic MSH6 P52701 M1267F 1267 M F 0.868 Pathogenic MSH6 P52701 M1267G 1267 M G 0.536 Pathogenic MSH6 P52701 M1267H 1267 M H 0.936 Pathogenic MSH6 P52701 M1267I 1267 M I 0.84 Pathogenic MSH6 P52701 M1267K 1267 M K 0.958 Pathogenic MSH6 P52701 M1267L 1267 M L 0.482 Neutral MSH6 P52701 M1267N 1267 M N 0.908 Pathogenic MSH6 P52701 M1267P 1267 M P 0.932 Pathogenic MSH6 P52701 M1267Q 1267 M Q 0.79 Pathogenic MSH6 P52701 M1267R 1267 M R 0.958 Pathogenic MSH6 P52701 M1267S 1267 M S 0.902 Pathogenic MSH6 P52701 M1267T 1267 M T 0.772 Pathogenic MSH6 P52701 M1267V 1267 M V 0.652 Pathogenic MSH6 P52701 M1267W 1267 M W 0.986 Pathogenic MSH6 P52701 M1267Y 1267 M Y 0.976 Pathogenic MSH6 P52701 A1268C 1268 A C 0.69 Pathogenic MSH6 P52701 A1268D 1268 A D 0.724 Pathogenic MSH6 P52701 A1268E 1268 A E 0.65 Pathogenic MSH6 P52701 A1268F 1268 A F 0.968 Pathogenic MSH6 P52701 A1268G 1268 A G 0.032 Neutral MSH6 P52701 A1268H 1268 A H 0.872 Pathogenic MSH6 P52701 A1268I 1268 A I 0.93 Pathogenic MSH6 P52701 A1268K 1268 A K 0.562 Pathogenic MSH6 P52701 A1268L 1268 A L 0.948 Pathogenic MSH6 P52701 A1268M 1268 A M 0.838 Pathogenic MSH6 P52701 A1268N 1268 A N 0.772 Pathogenic MSH6 P52701 A1268P 1268 A P 0.872 Pathogenic MSH6 P52701 A1268Q 1268 A Q 0.514 Pathogenic MSH6 P52701 A1268R 1268 A R 0.634 Pathogenic MSH6 P52701 A1268S 1268 A S 0.024 Neutral MSH6 P52701 A1268T 1268 A T 0.228 Neutral MSH6 P52701 A1268V 1268 A V 0.156 Neutral MSH6 P52701 A1268W 1268 A W 0.954 Pathogenic MSH6 P52701 A1268Y 1268 A Y 0.94 Pathogenic MSH6 P52701 C1269A 1269 C A 0.12 Neutral MSH6 P52701 C1269D 1269 C D 0.882 Pathogenic MSH6 P52701 C1269E 1269 C E 0.89 Pathogenic MSH6 P52701 C1269F 1269 C F 0.898 Pathogenic MSH6 P52701 C1269G 1269 C G 0.884 Pathogenic MSH6 P52701 C1269H 1269 C H 0.892 Pathogenic MSH6 P52701 C1269I 1269 C I 0.382 Neutral MSH6 P52701 C1269K 1269 C K 0.878 Pathogenic MSH6 P52701 C1269L 1269 C L 0.982 Pathogenic MSH6 P52701 C1269M 1269 C M 0.802 Pathogenic MSH6 P52701 C1269N 1269 C N 0.698 Pathogenic MSH6 P52701 C1269P 1269 C P 0.972 Pathogenic MSH6 P52701 C1269Q 1269 C Q 0.718 Pathogenic MSH6 P52701 C1269R 1269 C R 0.75 Pathogenic MSH6 P52701 C1269S 1269 C S 0.316 Neutral MSH6 P52701 C1269T 1269 C T 0.772 Pathogenic MSH6 P52701 C1269V 1269 C V 0.38 Neutral MSH6 P52701 C1269W 1269 C W 0.996 Pathogenic MSH6 P52701 C1269Y 1269 C Y 0.788 Pathogenic MSH6 P52701 V127A 127 V A 0 Neutral MSH6 P52701 V127C 127 V C 0.058 Neutral MSH6 P52701 V127D 127 V D 0.126 Neutral MSH6 P52701 V127E 127 V E 0.2 Neutral MSH6 P52701 V127F 127 V F 0.15 Neutral MSH6 P52701 V127G 127 V G 0.118 Neutral MSH6 P52701 V127H 127 V H 0.112 Neutral MSH6 P52701 V127I 127 V I 0.038 Neutral MSH6 P52701 V127K 127 V K 0.158 Neutral MSH6 P52701 V127L 127 V L 0 Neutral MSH6 P52701 V127M 127 V M 0.034 Neutral MSH6 P52701 V127N 127 V N 0.138 Neutral MSH6 P52701 V127P 127 V P 0.046 Neutral MSH6 P52701 V127Q 127 V Q 0.05 Neutral MSH6 P52701 V127R 127 V R 0.274 Neutral MSH6 P52701 V127S 127 V S 0.01 Neutral MSH6 P52701 V127T 127 V T 0.03 Neutral MSH6 P52701 V127W 127 V W 0.344 Neutral MSH6 P52701 V127Y 127 V Y 0.256 Neutral MSH6 P52701 M1270A 1270 M A 0.118 Neutral MSH6 P52701 M1270C 1270 M C 0.188 Neutral MSH6 P52701 M1270D 1270 M D 0.162 Neutral MSH6 P52701 M1270E 1270 M E 0.024 Neutral MSH6 P52701 M1270F 1270 M F 0.76 Pathogenic MSH6 P52701 M1270G 1270 M G 0.328 Neutral MSH6 P52701 M1270H 1270 M H 0.032 Neutral MSH6 P52701 M1270I 1270 M I 0.06 Neutral MSH6 P52701 M1270K 1270 M K 0.192 Neutral MSH6 P52701 M1270L 1270 M L 0.046 Neutral MSH6 P52701 M1270N 1270 M N 0.628 Pathogenic MSH6 P52701 M1270P 1270 M P 0.862 Pathogenic MSH6 P52701 M1270Q 1270 M Q 0.016 Neutral MSH6 P52701 M1270R 1270 M R 0.1 Neutral MSH6 P52701 M1270S 1270 M S 0.48 Neutral MSH6 P52701 M1270T 1270 M T 0.43 Neutral MSH6 P52701 M1270V 1270 M V 0.066 Neutral MSH6 P52701 M1270W 1270 M W 0.96 Pathogenic MSH6 P52701 M1270Y 1270 M Y 0.872 Pathogenic MSH6 P52701 V1271A 1271 V A 0.172 Neutral MSH6 P52701 V1271C 1271 V C 0.784 Pathogenic MSH6 P52701 V1271D 1271 V D 0.836 Pathogenic MSH6 P52701 V1271E 1271 V E 0.94 Pathogenic MSH6 P52701 V1271F 1271 V F 0.7 Pathogenic MSH6 P52701 V1271G 1271 V G 0.91 Pathogenic MSH6 P52701 V1271H 1271 V H 0.89 Pathogenic MSH6 P52701 V1271I 1271 V I 0.28 Neutral MSH6 P52701 V1271K 1271 V K 0.96 Pathogenic MSH6 P52701 V1271L 1271 V L 0.426 Neutral MSH6 P52701 V1271M 1271 V M 0.498 Neutral MSH6 P52701 V1271N 1271 V N 0.894 Pathogenic MSH6 P52701 V1271P 1271 V P 0.982 Pathogenic MSH6 P52701 V1271Q 1271 V Q 0.948 Pathogenic MSH6 P52701 V1271R 1271 V R 0.938 Pathogenic MSH6 P52701 V1271S 1271 V S 0.79 Pathogenic MSH6 P52701 V1271T 1271 V T 0.864 Pathogenic MSH6 P52701 V1271W 1271 V W 0.956 Pathogenic MSH6 P52701 V1271Y 1271 V Y 0.976 Pathogenic MSH6 P52701 E1272A 1272 E A 0.538 Pathogenic MSH6 P52701 E1272C 1272 E C 0.448 Neutral MSH6 P52701 E1272D 1272 E D 0.016 Neutral MSH6 P52701 E1272F 1272 E F 0.808 Pathogenic MSH6 P52701 E1272G 1272 E G 0.026 Neutral MSH6 P52701 E1272H 1272 E H 0.596 Pathogenic MSH6 P52701 E1272I 1272 E I 0.91 Pathogenic MSH6 P52701 E1272K 1272 E K 0.708 Pathogenic MSH6 P52701 E1272L 1272 E L 0.81 Pathogenic MSH6 P52701 E1272M 1272 E M 0.69 Pathogenic MSH6 P52701 E1272N 1272 E N 0.11 Neutral MSH6 P52701 E1272P 1272 E P 0.87 Pathogenic MSH6 P52701 E1272Q 1272 E Q 0.3 Neutral MSH6 P52701 E1272R 1272 E R 0.53 Pathogenic MSH6 P52701 E1272S 1272 E S 0.074 Neutral MSH6 P52701 E1272T 1272 E T 0.606 Pathogenic MSH6 P52701 E1272V 1272 E V 0.826 Pathogenic MSH6 P52701 E1272W 1272 E W 0.968 Pathogenic MSH6 P52701 E1272Y 1272 E Y 0.91 Pathogenic MSH6 P52701 N1273A 1273 N A 0.444 Neutral MSH6 P52701 N1273C 1273 N C 0.542 Pathogenic MSH6 P52701 N1273D 1273 N D 0.036 Neutral MSH6 P52701 N1273E 1273 N E 0.038 Neutral MSH6 P52701 N1273F 1273 N F 0.842 Pathogenic MSH6 P52701 N1273G 1273 N G 0.074 Neutral MSH6 P52701 N1273H 1273 N H 0.728 Pathogenic MSH6 P52701 N1273I 1273 N I 0.8 Pathogenic MSH6 P52701 N1273K 1273 N K 0.068 Neutral MSH6 P52701 N1273L 1273 N L 0.794 Pathogenic MSH6 P52701 N1273M 1273 N M 0.758 Pathogenic MSH6 P52701 N1273P 1273 N P 0.7 Pathogenic MSH6 P52701 N1273Q 1273 N Q 0.608 Pathogenic MSH6 P52701 N1273R 1273 N R 0.492 Neutral MSH6 P52701 N1273S 1273 N S 0.04 Neutral MSH6 P52701 N1273T 1273 N T 0.03 Neutral MSH6 P52701 N1273V 1273 N V 0.838 Pathogenic MSH6 P52701 N1273W 1273 N W 0.914 Pathogenic MSH6 P52701 N1273Y 1273 N Y 0.892 Pathogenic MSH6 P52701 E1274A 1274 E A 0.516 Pathogenic MSH6 P52701 E1274C 1274 E C 0.462 Neutral MSH6 P52701 E1274D 1274 E D 0.038 Neutral MSH6 P52701 E1274F 1274 E F 0.836 Pathogenic MSH6 P52701 E1274G 1274 E G 0.036 Neutral MSH6 P52701 E1274H 1274 E H 0.59 Pathogenic MSH6 P52701 E1274I 1274 E I 0.904 Pathogenic MSH6 P52701 E1274K 1274 E K 0.704 Pathogenic MSH6 P52701 E1274L 1274 E L 0.878 Pathogenic MSH6 P52701 E1274M 1274 E M 0.68 Pathogenic MSH6 P52701 E1274N 1274 E N 0.296 Neutral MSH6 P52701 E1274P 1274 E P 0.866 Pathogenic MSH6 P52701 E1274Q 1274 E Q 0.306 Neutral MSH6 P52701 E1274R 1274 E R 0.526 Pathogenic MSH6 P52701 E1274S 1274 E S 0.458 Neutral MSH6 P52701 E1274T 1274 E T 0.574 Pathogenic MSH6 P52701 E1274V 1274 E V 0.822 Pathogenic MSH6 P52701 E1274W 1274 E W 0.968 Pathogenic MSH6 P52701 E1274Y 1274 E Y 0.906 Pathogenic MSH6 P52701 C1275A 1275 C A 0.004 Neutral MSH6 P52701 C1275D 1275 C D 0.012 Neutral MSH6 P52701 C1275E 1275 C E 0.034 Neutral MSH6 P52701 C1275F 1275 C F 0.454 Neutral MSH6 P52701 C1275G 1275 C G 0.162 Neutral MSH6 P52701 C1275H 1275 C H 0.23 Neutral MSH6 P52701 C1275I 1275 C I 0.364 Neutral MSH6 P52701 C1275K 1275 C K 0.222 Neutral MSH6 P52701 C1275L 1275 C L 0.316 Neutral MSH6 P52701 C1275M 1275 C M 0.104 Neutral MSH6 P52701 C1275N 1275 C N 0 Neutral MSH6 P52701 C1275P 1275 C P 0.288 Neutral MSH6 P52701 C1275Q 1275 C Q 0.146 Neutral MSH6 P52701 C1275R 1275 C R 0.312 Neutral MSH6 P52701 C1275S 1275 C S 0.014 Neutral MSH6 P52701 C1275T 1275 C T 0.144 Neutral MSH6 P52701 C1275V 1275 C V 0.038 Neutral MSH6 P52701 C1275W 1275 C W 0.532 Pathogenic MSH6 P52701 C1275Y 1275 C Y 0.494 Neutral MSH6 P52701 E1276A 1276 E A 0.492 Neutral MSH6 P52701 E1276C 1276 E C 0.354 Neutral MSH6 P52701 E1276D 1276 E D 0.026 Neutral MSH6 P52701 E1276F 1276 E F 0.76 Pathogenic MSH6 P52701 E1276G 1276 E G 0.048 Neutral MSH6 P52701 E1276H 1276 E H 0.606 Pathogenic MSH6 P52701 E1276I 1276 E I 0.81 Pathogenic MSH6 P52701 E1276K 1276 E K 0.13 Neutral MSH6 P52701 E1276L 1276 E L 0.776 Pathogenic MSH6 P52701 E1276M 1276 E M 0.628 Pathogenic MSH6 P52701 E1276N 1276 E N 0.028 Neutral MSH6 P52701 E1276P 1276 E P 0.794 Pathogenic MSH6 P52701 E1276Q 1276 E Q 0.03 Neutral MSH6 P52701 E1276R 1276 E R 0.078 Neutral MSH6 P52701 E1276S 1276 E S 0.074 Neutral MSH6 P52701 E1276T 1276 E T 0.07 Neutral MSH6 P52701 E1276V 1276 E V 0.744 Pathogenic MSH6 P52701 E1276W 1276 E W 0.892 Pathogenic MSH6 P52701 E1276Y 1276 E Y 0.802 Pathogenic MSH6 P52701 D1277A 1277 D A 0.09 Neutral MSH6 P52701 D1277C 1277 D C 0.576 Pathogenic MSH6 P52701 D1277E 1277 D E 0.044 Neutral MSH6 P52701 D1277F 1277 D F 0.792 Pathogenic MSH6 P52701 D1277G 1277 D G 0.124 Neutral MSH6 P52701 D1277H 1277 D H 0.362 Neutral MSH6 P52701 D1277I 1277 D I 0.722 Pathogenic MSH6 P52701 D1277K 1277 D K 0.052 Neutral MSH6 P52701 D1277L 1277 D L 0.716 Pathogenic MSH6 P52701 D1277M 1277 D M 0.64 Pathogenic MSH6 P52701 D1277N 1277 D N 0.032 Neutral MSH6 P52701 D1277P 1277 D P 0.69 Pathogenic MSH6 P52701 D1277Q 1277 D Q 0.104 Neutral MSH6 P52701 D1277R 1277 D R 0.378 Neutral MSH6 P52701 D1277S 1277 D S 0.052 Neutral MSH6 P52701 D1277T 1277 D T 0.072 Neutral MSH6 P52701 D1277V 1277 D V 0.75 Pathogenic MSH6 P52701 D1277W 1277 D W 0.874 Pathogenic MSH6 P52701 D1277Y 1277 D Y 0.856 Pathogenic MSH6 P52701 P1278A 1278 P A 0.32 Neutral MSH6 P52701 P1278C 1278 P C 0.298 Neutral MSH6 P52701 P1278D 1278 P D 0.168 Neutral MSH6 P52701 P1278E 1278 P E 0.082 Neutral MSH6 P52701 P1278F 1278 P F 0.614 Pathogenic MSH6 P52701 P1278G 1278 P G 0.114 Neutral MSH6 P52701 P1278H 1278 P H 0.578 Pathogenic MSH6 P52701 P1278I 1278 P I 0.194 Neutral MSH6 P52701 P1278K 1278 P K 0.384 Neutral MSH6 P52701 P1278L 1278 P L 0.306 Neutral MSH6 P52701 P1278M 1278 P M 0.454 Neutral MSH6 P52701 P1278N 1278 P N 0.062 Neutral MSH6 P52701 P1278Q 1278 P Q 0.188 Neutral MSH6 P52701 P1278R 1278 P R 0.626 Pathogenic MSH6 P52701 P1278S 1278 P S 0.04 Neutral MSH6 P52701 P1278T 1278 P T 0.052 Neutral MSH6 P52701 P1278V 1278 P V 0.056 Neutral MSH6 P52701 P1278W 1278 P W 0.694 Pathogenic MSH6 P52701 P1278Y 1278 P Y 0.638 Pathogenic MSH6 P52701 S1279A 1279 S A 0.128 Neutral MSH6 P52701 S1279C 1279 S C 0.072 Neutral MSH6 P52701 S1279D 1279 S D 0.006 Neutral MSH6 P52701 S1279E 1279 S E 0.36 Neutral MSH6 P52701 S1279F 1279 S F 0.564 Pathogenic MSH6 P52701 S1279G 1279 S G 0.002 Neutral MSH6 P52701 S1279H 1279 S H 0.474 Neutral MSH6 P52701 S1279I 1279 S I 0.188 Neutral MSH6 P52701 S1279K 1279 S K 0.308 Neutral MSH6 P52701 S1279L 1279 S L 0.188 Neutral MSH6 P52701 S1279M 1279 S M 0.66 Pathogenic MSH6 P52701 S1279N 1279 S N 0.006 Neutral MSH6 P52701 S1279P 1279 S P 0.23 Neutral MSH6 P52701 S1279Q 1279 S Q 0.348 Neutral MSH6 P52701 S1279R 1279 S R 0.48 Neutral MSH6 P52701 S1279T 1279 S T 0.016 Neutral MSH6 P52701 S1279V 1279 S V 0.414 Neutral MSH6 P52701 S1279W 1279 S W 0.78 Pathogenic MSH6 P52701 S1279Y 1279 S Y 0.74 Pathogenic MSH6 P52701 R128A 128 R A 0.088 Neutral MSH6 P52701 R128C 128 R C 0.154 Neutral MSH6 P52701 R128D 128 R D 0.182 Neutral MSH6 P52701 R128E 128 R E 0.03 Neutral MSH6 P52701 R128F 128 R F 0.306 Neutral MSH6 P52701 R128G 128 R G 0.072 Neutral MSH6 P52701 R128H 128 R H 0.144 Neutral MSH6 P52701 R128I 128 R I 0.326 Neutral MSH6 P52701 R128K 128 R K 0.17 Neutral MSH6 P52701 R128L 128 R L 0.246 Neutral MSH6 P52701 R128M 128 R M 0.164 Neutral MSH6 P52701 R128N 128 R N 0.07 Neutral MSH6 P52701 R128P 128 R P 0.282 Neutral MSH6 P52701 R128Q 128 R Q 0.252 Neutral MSH6 P52701 R128S 128 R S 0.166 Neutral MSH6 P52701 R128T 128 R T 0.144 Neutral MSH6 P52701 R128V 128 R V 0.258 Neutral MSH6 P52701 R128W 128 R W 0.444 Neutral MSH6 P52701 R128Y 128 R Y 0.308 Neutral MSH6 P52701 Q1280A 1280 Q A 0.198 Neutral MSH6 P52701 Q1280C 1280 Q C 0.174 Neutral MSH6 P52701 Q1280D 1280 Q D 0.004 Neutral MSH6 P52701 Q1280E 1280 Q E 0.008 Neutral MSH6 P52701 Q1280F 1280 Q F 0.452 Neutral MSH6 P52701 Q1280G 1280 Q G 0.194 Neutral MSH6 P52701 Q1280H 1280 Q H 0.384 Neutral MSH6 P52701 Q1280I 1280 Q I 0.388 Neutral MSH6 P52701 Q1280K 1280 Q K 0.036 Neutral MSH6 P52701 Q1280L 1280 Q L 0.134 Neutral MSH6 P52701 Q1280M 1280 Q M 0.028 Neutral MSH6 P52701 Q1280N 1280 Q N 0.164 Neutral MSH6 P52701 Q1280P 1280 Q P 0.502 Pathogenic MSH6 P52701 Q1280R 1280 Q R 0.138 Neutral MSH6 P52701 Q1280S 1280 Q S 0.298 Neutral MSH6 P52701 Q1280T 1280 Q T 0.04 Neutral MSH6 P52701 Q1280V 1280 Q V 0.04 Neutral MSH6 P52701 Q1280W 1280 Q W 0.748 Pathogenic MSH6 P52701 Q1280Y 1280 Q Y 0.648 Pathogenic MSH6 P52701 E1281A 1281 E A 0.46 Neutral MSH6 P52701 E1281C 1281 E C 0.49 Neutral MSH6 P52701 E1281D 1281 E D 0.042 Neutral MSH6 P52701 E1281F 1281 E F 0.882 Pathogenic MSH6 P52701 E1281G 1281 E G 0.212 Neutral MSH6 P52701 E1281H 1281 E H 0.326 Neutral MSH6 P52701 E1281I 1281 E I 0.938 Pathogenic MSH6 P52701 E1281K 1281 E K 0.738 Pathogenic MSH6 P52701 E1281L 1281 E L 0.918 Pathogenic MSH6 P52701 E1281M 1281 E M 0.722 Pathogenic MSH6 P52701 E1281N 1281 E N 0.136 Neutral MSH6 P52701 E1281P 1281 E P 0.892 Pathogenic MSH6 P52701 E1281Q 1281 E Q 0.022 Neutral MSH6 P52701 E1281R 1281 E R 0.14 Neutral MSH6 P52701 E1281S 1281 E S 0.164 Neutral MSH6 P52701 E1281T 1281 E T 0.624 Pathogenic MSH6 P52701 E1281V 1281 E V 0.85 Pathogenic MSH6 P52701 E1281W 1281 E W 0.972 Pathogenic MSH6 P52701 E1281Y 1281 E Y 0.92 Pathogenic MSH6 P52701 T1282A 1282 T A 0.296 Neutral MSH6 P52701 T1282C 1282 T C 0.314 Neutral MSH6 P52701 T1282D 1282 T D 0.078 Neutral MSH6 P52701 T1282E 1282 T E 0.094 Neutral MSH6 P52701 T1282F 1282 T F 0.63 Pathogenic MSH6 P52701 T1282G 1282 T G 0.286 Neutral MSH6 P52701 T1282H 1282 T H 0.324 Neutral MSH6 P52701 T1282I 1282 T I 0.41 Neutral MSH6 P52701 T1282K 1282 T K 0.05 Neutral MSH6 P52701 T1282L 1282 T L 0.424 Neutral MSH6 P52701 T1282M 1282 T M 0.542 Pathogenic MSH6 P52701 T1282N 1282 T N 0.024 Neutral MSH6 P52701 T1282P 1282 T P 0.514 Pathogenic MSH6 P52701 T1282Q 1282 T Q 0.308 Neutral MSH6 P52701 T1282R 1282 T R 0.506 Pathogenic MSH6 P52701 T1282S 1282 T S 0.028 Neutral MSH6 P52701 T1282V 1282 T V 0.67 Pathogenic MSH6 P52701 T1282W 1282 T W 0.886 Pathogenic MSH6 P52701 T1282Y 1282 T Y 0.874 Pathogenic MSH6 P52701 I1283A 1283 I A 0.526 Pathogenic MSH6 P52701 I1283C 1283 I C 0.644 Pathogenic MSH6 P52701 I1283D 1283 I D 0.736 Pathogenic MSH6 P52701 I1283E 1283 I E 0.742 Pathogenic MSH6 P52701 I1283F 1283 I F 0.956 Pathogenic MSH6 P52701 I1283G 1283 I G 0.8 Pathogenic MSH6 P52701 I1283H 1283 I H 0.888 Pathogenic MSH6 P52701 I1283K 1283 I K 0.838 Pathogenic MSH6 P52701 I1283L 1283 I L 0.134 Neutral MSH6 P52701 I1283M 1283 I M 0.696 Pathogenic MSH6 P52701 I1283N 1283 I N 0.76 Pathogenic MSH6 P52701 I1283P 1283 I P 0.924 Pathogenic MSH6 P52701 I1283Q 1283 I Q 0.774 Pathogenic MSH6 P52701 I1283R 1283 I R 0.86 Pathogenic MSH6 P52701 I1283S 1283 I S 0.638 Pathogenic MSH6 P52701 I1283T 1283 I T 0.33 Neutral MSH6 P52701 I1283V 1283 I V 0.246 Neutral MSH6 P52701 I1283W 1283 I W 0.986 Pathogenic MSH6 P52701 I1283Y 1283 I Y 0.972 Pathogenic MSH6 P52701 T1284A 1284 T A 0.69 Pathogenic MSH6 P52701 T1284C 1284 T C 0.916 Pathogenic MSH6 P52701 T1284D 1284 T D 0.924 Pathogenic MSH6 P52701 T1284E 1284 T E 0.93 Pathogenic MSH6 P52701 T1284F 1284 T F 0.942 Pathogenic MSH6 P52701 T1284G 1284 T G 0.73 Pathogenic MSH6 P52701 T1284H 1284 T H 0.91 Pathogenic MSH6 P52701 T1284I 1284 T I 0.398 Neutral MSH6 P52701 T1284K 1284 T K 0.928 Pathogenic MSH6 P52701 T1284L 1284 T L 0.934 Pathogenic MSH6 P52701 T1284M 1284 T M 0.722 Pathogenic MSH6 P52701 T1284N 1284 T N 0.872 Pathogenic MSH6 P52701 T1284P 1284 T P 0.95 Pathogenic MSH6 P52701 T1284Q 1284 T Q 0.876 Pathogenic MSH6 P52701 T1284R 1284 T R 0.988 Pathogenic MSH6 P52701 T1284S 1284 T S 0.808 Pathogenic MSH6 P52701 T1284V 1284 T V 0.278 Neutral MSH6 P52701 T1284W 1284 T W 0.948 Pathogenic MSH6 P52701 T1284Y 1284 T Y 0.948 Pathogenic MSH6 P52701 F1285A 1285 F A 0.5 Pathogenic MSH6 P52701 F1285C 1285 F C 0.73 Pathogenic MSH6 P52701 F1285D 1285 F D 0.816 Pathogenic MSH6 P52701 F1285E 1285 F E 0.87 Pathogenic MSH6 P52701 F1285G 1285 F G 0.51 Pathogenic MSH6 P52701 F1285H 1285 F H 0.772 Pathogenic MSH6 P52701 F1285I 1285 F I 0.688 Pathogenic MSH6 P52701 F1285K 1285 F K 0.85 Pathogenic MSH6 P52701 F1285L 1285 F L 0.404 Neutral MSH6 P52701 F1285M 1285 F M 0.788 Pathogenic MSH6 P52701 F1285N 1285 F N 0.766 Pathogenic MSH6 P52701 F1285P 1285 F P 0.954 Pathogenic MSH6 P52701 F1285Q 1285 F Q 0.788 Pathogenic MSH6 P52701 F1285R 1285 F R 0.92 Pathogenic MSH6 P52701 F1285S 1285 F S 0.882 Pathogenic MSH6 P52701 F1285T 1285 F T 0.592 Pathogenic MSH6 P52701 F1285V 1285 F V 0.744 Pathogenic MSH6 P52701 F1285W 1285 F W 0.868 Pathogenic MSH6 P52701 F1285Y 1285 F Y 0.564 Pathogenic MSH6 P52701 L1286A 1286 L A 0.714 Pathogenic MSH6 P52701 L1286C 1286 L C 0.822 Pathogenic MSH6 P52701 L1286D 1286 L D 0.91 Pathogenic MSH6 P52701 L1286E 1286 L E 0.896 Pathogenic MSH6 P52701 L1286F 1286 L F 0.878 Pathogenic MSH6 P52701 L1286G 1286 L G 0.864 Pathogenic MSH6 P52701 L1286H 1286 L H 0.91 Pathogenic MSH6 P52701 L1286I 1286 L I 0.938 Pathogenic MSH6 P52701 L1286K 1286 L K 0.728 Pathogenic MSH6 P52701 L1286M 1286 L M 0.61 Pathogenic MSH6 P52701 L1286N 1286 L N 0.82 Pathogenic MSH6 P52701 L1286P 1286 L P 0.994 Pathogenic MSH6 P52701 L1286Q 1286 L Q 0.776 Pathogenic MSH6 P52701 L1286R 1286 L R 0.986 Pathogenic MSH6 P52701 L1286S 1286 L S 0.706 Pathogenic MSH6 P52701 L1286T 1286 L T 0.628 Pathogenic MSH6 P52701 L1286V 1286 L V 0.432 Neutral MSH6 P52701 L1286W 1286 L W 0.88 Pathogenic MSH6 P52701 L1286Y 1286 L Y 0.89 Pathogenic MSH6 P52701 Y1287A 1287 Y A 0.442 Neutral MSH6 P52701 Y1287C 1287 Y C 0.696 Pathogenic MSH6 P52701 Y1287D 1287 Y D 0.854 Pathogenic MSH6 P52701 Y1287E 1287 Y E 0.762 Pathogenic MSH6 P52701 Y1287F 1287 Y F 0.506 Pathogenic MSH6 P52701 Y1287G 1287 Y G 0.488 Neutral MSH6 P52701 Y1287H 1287 Y H 0.614 Pathogenic MSH6 P52701 Y1287I 1287 Y I 0.806 Pathogenic MSH6 P52701 Y1287K 1287 Y K 0.828 Pathogenic MSH6 P52701 Y1287L 1287 Y L 0.714 Pathogenic MSH6 P52701 Y1287M 1287 Y M 0.694 Pathogenic MSH6 P52701 Y1287N 1287 Y N 0.752 Pathogenic MSH6 P52701 Y1287P 1287 Y P 0.79 Pathogenic MSH6 P52701 Y1287Q 1287 Y Q 0.67 Pathogenic MSH6 P52701 Y1287R 1287 Y R 0.792 Pathogenic MSH6 P52701 Y1287S 1287 Y S 0.488 Neutral MSH6 P52701 Y1287T 1287 Y T 0.692 Pathogenic MSH6 P52701 Y1287V 1287 Y V 0.666 Pathogenic MSH6 P52701 Y1287W 1287 Y W 0.914 Pathogenic MSH6 P52701 K1288A 1288 K A 0.544 Pathogenic MSH6 P52701 K1288C 1288 K C 0.43 Neutral MSH6 P52701 K1288D 1288 K D 0.61 Pathogenic MSH6 P52701 K1288E 1288 K E 0.118 Neutral MSH6 P52701 K1288F 1288 K F 0.966 Pathogenic MSH6 P52701 K1288G 1288 K G 0.532 Pathogenic MSH6 P52701 K1288H 1288 K H 0.268 Neutral MSH6 P52701 K1288I 1288 K I 0.982 Pathogenic MSH6 P52701 K1288L 1288 K L 0.97 Pathogenic MSH6 P52701 K1288M 1288 K M 0.914 Pathogenic MSH6 P52701 K1288N 1288 K N 0.264 Neutral MSH6 P52701 K1288P 1288 K P 0.914 Pathogenic MSH6 P52701 K1288Q 1288 K Q 0.14 Neutral MSH6 P52701 K1288R 1288 K R 0.134 Neutral MSH6 P52701 K1288S 1288 K S 0.196 Neutral MSH6 P52701 K1288T 1288 K T 0.132 Neutral MSH6 P52701 K1288V 1288 K V 0.872 Pathogenic MSH6 P52701 K1288W 1288 K W 0.992 Pathogenic MSH6 P52701 K1288Y 1288 K Y 0.986 Pathogenic MSH6 P52701 F1289A 1289 F A 0.412 Neutral MSH6 P52701 F1289C 1289 F C 0.208 Neutral MSH6 P52701 F1289D 1289 F D 0.78 Pathogenic MSH6 P52701 F1289E 1289 F E 0.86 Pathogenic MSH6 P52701 F1289G 1289 F G 0.48 Neutral MSH6 P52701 F1289H 1289 F H 0.628 Pathogenic MSH6 P52701 F1289I 1289 F I 0.562 Pathogenic MSH6 P52701 F1289K 1289 F K 0.844 Pathogenic MSH6 P52701 F1289L 1289 F L 0.116 Neutral MSH6 P52701 F1289M 1289 F M 0.258 Neutral MSH6 P52701 F1289N 1289 F N 0.7 Pathogenic MSH6 P52701 F1289P 1289 F P 0.944 Pathogenic MSH6 P52701 F1289Q 1289 F Q 0.732 Pathogenic MSH6 P52701 F1289R 1289 F R 0.912 Pathogenic MSH6 P52701 F1289S 1289 F S 0.762 Pathogenic MSH6 P52701 F1289T 1289 F T 0.592 Pathogenic MSH6 P52701 F1289V 1289 F V 0.42 Neutral MSH6 P52701 F1289W 1289 F W 0.944 Pathogenic MSH6 P52701 F1289Y 1289 F Y 0.258 Neutral MSH6 P52701 V129A 129 V A 0.032 Neutral MSH6 P52701 V129C 129 V C 0.074 Neutral MSH6 P52701 V129D 129 V D 0.154 Neutral MSH6 P52701 V129E 129 V E 0.264 Neutral MSH6 P52701 V129F 129 V F 0.25 Neutral MSH6 P52701 V129G 129 V G 0.218 Neutral MSH6 P52701 V129H 129 V H 0.166 Neutral MSH6 P52701 V129I 129 V I 0.004 Neutral MSH6 P52701 V129K 129 V K 0.226 Neutral MSH6 P52701 V129L 129 V L 0.024 Neutral MSH6 P52701 V129M 129 V M 0.088 Neutral MSH6 P52701 V129N 129 V N 0.168 Neutral MSH6 P52701 V129P 129 V P 0.242 Neutral MSH6 P52701 V129Q 129 V Q 0.282 Neutral MSH6 P52701 V129R 129 V R 0.376 Neutral MSH6 P52701 V129S 129 V S 0.086 Neutral MSH6 P52701 V129T 129 V T 0.104 Neutral MSH6 P52701 V129W 129 V W 0.426 Neutral MSH6 P52701 V129Y 129 V Y 0.342 Neutral MSH6 P52701 I1290A 1290 I A 0.07 Neutral MSH6 P52701 I1290C 1290 I C 0.24 Neutral MSH6 P52701 I1290D 1290 I D 0.544 Pathogenic MSH6 P52701 I1290E 1290 I E 0.102 Neutral MSH6 P52701 I1290F 1290 I F 0.642 Pathogenic MSH6 P52701 I1290G 1290 I G 0.19 Neutral MSH6 P52701 I1290H 1290 I H 0.382 Neutral MSH6 P52701 I1290K 1290 I K 0.3 Neutral MSH6 P52701 I1290L 1290 I L 0.442 Neutral MSH6 P52701 I1290M 1290 I M 0.426 Neutral MSH6 P52701 I1290N 1290 I N 0.586 Pathogenic MSH6 P52701 I1290P 1290 I P 0.648 Pathogenic MSH6 P52701 I1290Q 1290 I Q 0.564 Pathogenic MSH6 P52701 I1290R 1290 I R 0.538 Pathogenic MSH6 P52701 I1290S 1290 I S 0.114 Neutral MSH6 P52701 I1290T 1290 I T 0.034 Neutral MSH6 P52701 I1290V 1290 I V 0.014 Neutral MSH6 P52701 I1290W 1290 I W 0.858 Pathogenic MSH6 P52701 I1290Y 1290 I Y 0.856 Pathogenic MSH6 P52701 K1291A 1291 K A 0.068 Neutral MSH6 P52701 K1291C 1291 K C 0.216 Neutral MSH6 P52701 K1291D 1291 K D 0.014 Neutral MSH6 P52701 K1291E 1291 K E 0.016 Neutral MSH6 P52701 K1291F 1291 K F 0.746 Pathogenic MSH6 P52701 K1291G 1291 K G 0.1 Neutral MSH6 P52701 K1291H 1291 K H 0.21 Neutral MSH6 P52701 K1291I 1291 K I 0.796 Pathogenic MSH6 P52701 K1291L 1291 K L 0.68 Pathogenic MSH6 P52701 K1291M 1291 K M 0.556 Pathogenic MSH6 P52701 K1291N 1291 K N 0.03 Neutral MSH6 P52701 K1291P 1291 K P 0.07 Neutral MSH6 P52701 K1291Q 1291 K Q 0.156 Neutral MSH6 P52701 K1291R 1291 K R 0.018 Neutral MSH6 P52701 K1291S 1291 K S 0.032 Neutral MSH6 P52701 K1291T 1291 K T 0.038 Neutral MSH6 P52701 K1291V 1291 K V 0.706 Pathogenic MSH6 P52701 K1291W 1291 K W 0.93 Pathogenic MSH6 P52701 K1291Y 1291 K Y 0.866 Pathogenic MSH6 P52701 G1292A 1292 G A 0.96 Pathogenic MSH6 P52701 G1292C 1292 G C 0.946 Pathogenic MSH6 P52701 G1292D 1292 G D 0.998 Pathogenic MSH6 P52701 G1292E 1292 G E 0.984 Pathogenic MSH6 P52701 G1292F 1292 G F 0.982 Pathogenic MSH6 P52701 G1292H 1292 G H 0.986 Pathogenic MSH6 P52701 G1292I 1292 G I 0.974 Pathogenic MSH6 P52701 G1292K 1292 G K 0.986 Pathogenic MSH6 P52701 G1292L 1292 G L 0.984 Pathogenic MSH6 P52701 G1292M 1292 G M 0.994 Pathogenic MSH6 P52701 G1292N 1292 G N 0.986 Pathogenic MSH6 P52701 G1292P 1292 G P 0.96 Pathogenic MSH6 P52701 G1292Q 1292 G Q 0.994 Pathogenic MSH6 P52701 G1292R 1292 G R 1 Pathogenic MSH6 P52701 G1292S 1292 G S 0.538 Pathogenic MSH6 P52701 G1292T 1292 G T 0.834 Pathogenic MSH6 P52701 G1292V 1292 G V 0.986 Pathogenic MSH6 P52701 G1292W 1292 G W 0.978 Pathogenic MSH6 P52701 G1292Y 1292 G Y 0.954 Pathogenic MSH6 P52701 A1293C 1293 A C 0.732 Pathogenic MSH6 P52701 A1293D 1293 A D 0.84 Pathogenic MSH6 P52701 A1293E 1293 A E 0.792 Pathogenic MSH6 P52701 A1293F 1293 A F 0.958 Pathogenic MSH6 P52701 A1293G 1293 A G 0.388 Neutral MSH6 P52701 A1293H 1293 A H 0.792 Pathogenic MSH6 P52701 A1293I 1293 A I 0.628 Pathogenic MSH6 P52701 A1293K 1293 A K 0.898 Pathogenic MSH6 P52701 A1293L 1293 A L 0.944 Pathogenic MSH6 P52701 A1293M 1293 A M 0.544 Pathogenic MSH6 P52701 A1293N 1293 A N 0.626 Pathogenic MSH6 P52701 A1293P 1293 A P 0.166 Neutral MSH6 P52701 A1293Q 1293 A Q 0.782 Pathogenic MSH6 P52701 A1293R 1293 A R 0.748 Pathogenic MSH6 P52701 A1293S 1293 A S 0.01 Neutral MSH6 P52701 A1293T 1293 A T 0.076 Neutral MSH6 P52701 A1293V 1293 A V 0.144 Neutral MSH6 P52701 A1293W 1293 A W 0.95 Pathogenic MSH6 P52701 A1293Y 1293 A Y 0.932 Pathogenic MSH6 P52701 C1294A 1294 C A 0.142 Neutral MSH6 P52701 C1294D 1294 C D 0.94 Pathogenic MSH6 P52701 C1294E 1294 C E 0.904 Pathogenic MSH6 P52701 C1294F 1294 C F 0.996 Pathogenic MSH6 P52701 C1294G 1294 C G 0.922 Pathogenic MSH6 P52701 C1294H 1294 C H 0.886 Pathogenic MSH6 P52701 C1294I 1294 C I 0.964 Pathogenic MSH6 P52701 C1294K 1294 C K 0.898 Pathogenic MSH6 P52701 C1294L 1294 C L 0.99 Pathogenic MSH6 P52701 C1294M 1294 C M 0.81 Pathogenic MSH6 P52701 C1294N 1294 C N 0.78 Pathogenic MSH6 P52701 C1294P 1294 C P 0.978 Pathogenic MSH6 P52701 C1294Q 1294 C Q 0.71 Pathogenic MSH6 P52701 C1294R 1294 C R 0.996 Pathogenic MSH6 P52701 C1294S 1294 C S 0.126 Neutral MSH6 P52701 C1294T 1294 C T 0.776 Pathogenic MSH6 P52701 C1294V 1294 C V 0.964 Pathogenic MSH6 P52701 C1294W 1294 C W 0.996 Pathogenic MSH6 P52701 C1294Y 1294 C Y 0.992 Pathogenic MSH6 P52701 P1295A 1295 P A 0.804 Pathogenic MSH6 P52701 P1295C 1295 P C 0.9 Pathogenic MSH6 P52701 P1295D 1295 P D 0.84 Pathogenic MSH6 P52701 P1295E 1295 P E 0.27 Neutral MSH6 P52701 P1295F 1295 P F 0.996 Pathogenic MSH6 P52701 P1295G 1295 P G 0.582 Pathogenic MSH6 P52701 P1295H 1295 P H 0.978 Pathogenic MSH6 P52701 P1295I 1295 P I 0.932 Pathogenic MSH6 P52701 P1295K 1295 P K 0.952 Pathogenic MSH6 P52701 P1295L 1295 P L 0.994 Pathogenic MSH6 P52701 P1295M 1295 P M 0.954 Pathogenic MSH6 P52701 P1295N 1295 P N 0.382 Neutral MSH6 P52701 P1295Q 1295 P Q 0.356 Neutral MSH6 P52701 P1295R 1295 P R 0.98 Pathogenic MSH6 P52701 P1295S 1295 P S 0.098 Neutral MSH6 P52701 P1295T 1295 P T 0.704 Pathogenic MSH6 P52701 P1295V 1295 P V 0.838 Pathogenic MSH6 P52701 P1295W 1295 P W 0.94 Pathogenic MSH6 P52701 P1295Y 1295 P Y 0.94 Pathogenic MSH6 P52701 K1296A 1296 K A 0.6 Pathogenic MSH6 P52701 K1296C 1296 K C 0.478 Neutral MSH6 P52701 K1296D 1296 K D 0.19 Neutral MSH6 P52701 K1296E 1296 K E 0.328 Neutral MSH6 P52701 K1296F 1296 K F 0.95 Pathogenic MSH6 P52701 K1296G 1296 K G 0.172 Neutral MSH6 P52701 K1296H 1296 K H 0.8 Pathogenic MSH6 P52701 K1296I 1296 K I 0.966 Pathogenic MSH6 P52701 K1296L 1296 K L 0.96 Pathogenic MSH6 P52701 K1296M 1296 K M 0.898 Pathogenic MSH6 P52701 K1296N 1296 K N 0.31 Neutral MSH6 P52701 K1296P 1296 K P 0.904 Pathogenic MSH6 P52701 K1296Q 1296 K Q 0.796 Pathogenic MSH6 P52701 K1296R 1296 K R 0.202 Neutral MSH6 P52701 K1296S 1296 K S 0.682 Pathogenic MSH6 P52701 K1296T 1296 K T 0.302 Neutral MSH6 P52701 K1296V 1296 K V 0.862 Pathogenic MSH6 P52701 K1296W 1296 K W 0.984 Pathogenic MSH6 P52701 K1296Y 1296 K Y 0.976 Pathogenic MSH6 P52701 S1297A 1297 S A 0.87 Pathogenic MSH6 P52701 S1297C 1297 S C 0.904 Pathogenic MSH6 P52701 S1297D 1297 S D 0.912 Pathogenic MSH6 P52701 S1297E 1297 S E 0.962 Pathogenic MSH6 P52701 S1297F 1297 S F 0.982 Pathogenic MSH6 P52701 S1297G 1297 S G 0.696 Pathogenic MSH6 P52701 S1297H 1297 S H 0.974 Pathogenic MSH6 P52701 S1297I 1297 S I 0.886 Pathogenic MSH6 P52701 S1297K 1297 S K 0.954 Pathogenic MSH6 P52701 S1297L 1297 S L 0.926 Pathogenic MSH6 P52701 S1297M 1297 S M 0.998 Pathogenic MSH6 P52701 S1297N 1297 S N 0.892 Pathogenic MSH6 P52701 S1297P 1297 S P 0.97 Pathogenic MSH6 P52701 S1297Q 1297 S Q 0.952 Pathogenic MSH6 P52701 S1297R 1297 S R 0.972 Pathogenic MSH6 P52701 S1297T 1297 S T 0.748 Pathogenic MSH6 P52701 S1297V 1297 S V 0.954 Pathogenic MSH6 P52701 S1297W 1297 S W 0.954 Pathogenic MSH6 P52701 S1297Y 1297 S Y 0.962 Pathogenic MSH6 P52701 Y1298A 1298 Y A 0.374 Neutral MSH6 P52701 Y1298C 1298 Y C 0.604 Pathogenic MSH6 P52701 Y1298D 1298 Y D 0.78 Pathogenic MSH6 P52701 Y1298E 1298 Y E 0.688 Pathogenic MSH6 P52701 Y1298F 1298 Y F 0.094 Neutral MSH6 P52701 Y1298G 1298 Y G 0.426 Neutral MSH6 P52701 Y1298H 1298 Y H 0.126 Neutral MSH6 P52701 Y1298I 1298 Y I 0.738 Pathogenic MSH6 P52701 Y1298K 1298 Y K 0.792 Pathogenic MSH6 P52701 Y1298L 1298 Y L 0.626 Pathogenic MSH6 P52701 Y1298M 1298 Y M 0.63 Pathogenic MSH6 P52701 Y1298N 1298 Y N 0.66 Pathogenic MSH6 P52701 Y1298P 1298 Y P 0.748 Pathogenic MSH6 P52701 Y1298Q 1298 Y Q 0.568 Pathogenic MSH6 P52701 Y1298R 1298 Y R 0.712 Pathogenic MSH6 P52701 Y1298S 1298 Y S 0.422 Neutral MSH6 P52701 Y1298T 1298 Y T 0.596 Pathogenic MSH6 P52701 Y1298V 1298 Y V 0.758 Pathogenic MSH6 P52701 Y1298W 1298 Y W 0.852 Pathogenic MSH6 P52701 G1299A 1299 G A 0.966 Pathogenic MSH6 P52701 G1299C 1299 G C 0.946 Pathogenic MSH6 P52701 G1299D 1299 G D 0.998 Pathogenic MSH6 P52701 G1299E 1299 G E 0.986 Pathogenic MSH6 P52701 G1299F 1299 G F 0.982 Pathogenic MSH6 P52701 G1299H 1299 G H 0.986 Pathogenic MSH6 P52701 G1299I 1299 G I 0.974 Pathogenic MSH6 P52701 G1299K 1299 G K 0.986 Pathogenic MSH6 P52701 G1299L 1299 G L 0.984 Pathogenic MSH6 P52701 G1299M 1299 G M 0.994 Pathogenic MSH6 P52701 G1299N 1299 G N 0.986 Pathogenic MSH6 P52701 G1299P 1299 G P 0.964 Pathogenic MSH6 P52701 G1299Q 1299 G Q 0.994 Pathogenic MSH6 P52701 G1299R 1299 G R 1 Pathogenic MSH6 P52701 G1299S 1299 G S 0.824 Pathogenic MSH6 P52701 G1299T 1299 G T 0.84 Pathogenic MSH6 P52701 G1299V 1299 G V 0.986 Pathogenic MSH6 P52701 G1299W 1299 G W 0.978 Pathogenic MSH6 P52701 G1299Y 1299 G Y 0.958 Pathogenic MSH6 P52701 K13A 13 K A 0.054 Neutral MSH6 P52701 K13C 13 K C 0.028 Neutral MSH6 P52701 K13D 13 K D 0.066 Neutral MSH6 P52701 K13E 13 K E 0.072 Neutral MSH6 P52701 K13F 13 K F 0.22 Neutral MSH6 P52701 K13G 13 K G 0.13 Neutral MSH6 P52701 K13H 13 K H 0.048 Neutral MSH6 P52701 K13I 13 K I 0.23 Neutral MSH6 P52701 K13L 13 K L 0.222 Neutral MSH6 P52701 K13M 13 K M 0.112 Neutral MSH6 P52701 K13N 13 K N 0.082 Neutral MSH6 P52701 K13P 13 K P 0.242 Neutral MSH6 P52701 K13Q 13 K Q 0.09 Neutral MSH6 P52701 K13R 13 K R 0.056 Neutral MSH6 P52701 K13S 13 K S 0.014 Neutral MSH6 P52701 K13T 13 K T 0.182 Neutral MSH6 P52701 K13V 13 K V 0.186 Neutral MSH6 P52701 K13W 13 K W 0.414 Neutral MSH6 P52701 K13Y 13 K Y 0.344 Neutral MSH6 P52701 H130A 130 H A 0.108 Neutral MSH6 P52701 H130C 130 H C 0.07 Neutral MSH6 P52701 H130D 130 H D 0.052 Neutral MSH6 P52701 H130E 130 H E 0.09 Neutral MSH6 P52701 H130F 130 H F 0.346 Neutral MSH6 P52701 H130G 130 H G 0.152 Neutral MSH6 P52701 H130I 130 H I 0.404 Neutral MSH6 P52701 H130K 130 H K 0.172 Neutral MSH6 P52701 H130L 130 H L 0.358 Neutral MSH6 P52701 H130M 130 H M 0.178 Neutral MSH6 P52701 H130N 130 H N 0.082 Neutral MSH6 P52701 H130P 130 H P 0.444 Neutral MSH6 P52701 H130Q 130 H Q 0.126 Neutral MSH6 P52701 H130R 130 H R 0.074 Neutral MSH6 P52701 H130S 130 H S 0.204 Neutral MSH6 P52701 H130T 130 H T 0.224 Neutral MSH6 P52701 H130V 130 H V 0.216 Neutral MSH6 P52701 H130W 130 H W 0.644 Pathogenic MSH6 P52701 H130Y 130 H Y 0.412 Neutral MSH6 P52701 F1300A 1300 F A 0.408 Neutral MSH6 P52701 F1300C 1300 F C 0.554 Pathogenic MSH6 P52701 F1300D 1300 F D 0.822 Pathogenic MSH6 P52701 F1300E 1300 F E 0.922 Pathogenic MSH6 P52701 F1300G 1300 F G 0.502 Pathogenic MSH6 P52701 F1300H 1300 F H 0.606 Pathogenic MSH6 P52701 F1300I 1300 F I 0.112 Neutral MSH6 P52701 F1300K 1300 F K 0.882 Pathogenic MSH6 P52701 F1300L 1300 F L 0.082 Neutral MSH6 P52701 F1300M 1300 F M 0.076 Neutral MSH6 P52701 F1300N 1300 F N 0.752 Pathogenic MSH6 P52701 F1300P 1300 F P 0.864 Pathogenic MSH6 P52701 F1300Q 1300 F Q 0.79 Pathogenic MSH6 P52701 F1300R 1300 F R 0.928 Pathogenic MSH6 P52701 F1300S 1300 F S 0.668 Pathogenic MSH6 P52701 F1300T 1300 F T 0.374 Neutral MSH6 P52701 F1300V 1300 F V 0.154 Neutral MSH6 P52701 F1300W 1300 F W 0.808 Pathogenic MSH6 P52701 F1300Y 1300 F Y 0.506 Pathogenic MSH6 P52701 N1301A 1301 N A 0.688 Pathogenic MSH6 P52701 N1301C 1301 N C 0.768 Pathogenic MSH6 P52701 N1301D 1301 N D 0.83 Pathogenic MSH6 P52701 N1301E 1301 N E 0.718 Pathogenic MSH6 P52701 N1301F 1301 N F 0.656 Pathogenic MSH6 P52701 N1301G 1301 N G 0.868 Pathogenic MSH6 P52701 N1301H 1301 N H 0.392 Neutral MSH6 P52701 N1301I 1301 N I 0.944 Pathogenic MSH6 P52701 N1301K 1301 N K 0.868 Pathogenic MSH6 P52701 N1301L 1301 N L 0.962 Pathogenic MSH6 P52701 N1301M 1301 N M 0.966 Pathogenic MSH6 P52701 N1301P 1301 N P 0.872 Pathogenic MSH6 P52701 N1301Q 1301 N Q 0.95 Pathogenic MSH6 P52701 N1301R 1301 N R 0.908 Pathogenic MSH6 P52701 N1301S 1301 N S 0.912 Pathogenic MSH6 P52701 N1301T 1301 N T 0.666 Pathogenic MSH6 P52701 N1301V 1301 N V 0.982 Pathogenic MSH6 P52701 N1301W 1301 N W 0.978 Pathogenic MSH6 P52701 N1301Y 1301 N Y 0.816 Pathogenic MSH6 P52701 A1302C 1302 A C 0.366 Neutral MSH6 P52701 A1302D 1302 A D 0.934 Pathogenic MSH6 P52701 A1302E 1302 A E 0.964 Pathogenic MSH6 P52701 A1302F 1302 A F 0.99 Pathogenic MSH6 P52701 A1302G 1302 A G 0.736 Pathogenic MSH6 P52701 A1302H 1302 A H 0.924 Pathogenic MSH6 P52701 A1302I 1302 A I 0.918 Pathogenic MSH6 P52701 A1302K 1302 A K 0.962 Pathogenic MSH6 P52701 A1302L 1302 A L 0.994 Pathogenic MSH6 P52701 A1302M 1302 A M 0.89 Pathogenic MSH6 P52701 A1302N 1302 A N 0.87 Pathogenic MSH6 P52701 A1302P 1302 A P 0.966 Pathogenic MSH6 P52701 A1302Q 1302 A Q 0.898 Pathogenic MSH6 P52701 A1302R 1302 A R 0.962 Pathogenic MSH6 P52701 A1302S 1302 A S 0.586 Pathogenic MSH6 P52701 A1302T 1302 A T 0.902 Pathogenic MSH6 P52701 A1302V 1302 A V 0.426 Neutral MSH6 P52701 A1302W 1302 A W 0.99 Pathogenic MSH6 P52701 A1302Y 1302 A Y 0.956 Pathogenic MSH6 P52701 A1303C 1303 A C 0.856 Pathogenic MSH6 P52701 A1303D 1303 A D 0.926 Pathogenic MSH6 P52701 A1303E 1303 A E 0.876 Pathogenic MSH6 P52701 A1303F 1303 A F 0.966 Pathogenic MSH6 P52701 A1303G 1303 A G 0.488 Neutral MSH6 P52701 A1303H 1303 A H 0.866 Pathogenic MSH6 P52701 A1303I 1303 A I 0.96 Pathogenic MSH6 P52701 A1303K 1303 A K 0.936 Pathogenic MSH6 P52701 A1303L 1303 A L 0.98 Pathogenic MSH6 P52701 A1303M 1303 A M 0.852 Pathogenic MSH6 P52701 A1303N 1303 A N 0.862 Pathogenic MSH6 P52701 A1303P 1303 A P 0.968 Pathogenic MSH6 P52701 A1303Q 1303 A Q 0.816 Pathogenic MSH6 P52701 A1303R 1303 A R 0.958 Pathogenic MSH6 P52701 A1303S 1303 A S 0.42 Neutral MSH6 P52701 A1303T 1303 A T 0.728 Pathogenic MSH6 P52701 A1303V 1303 A V 0.91 Pathogenic MSH6 P52701 A1303W 1303 A W 0.976 Pathogenic MSH6 P52701 A1303Y 1303 A Y 0.964 Pathogenic MSH6 P52701 R1304A 1304 R A 0.108 Neutral MSH6 P52701 R1304C 1304 R C 0.662 Pathogenic MSH6 P52701 R1304D 1304 R D 0.628 Pathogenic MSH6 P52701 R1304E 1304 R E 0.55 Pathogenic MSH6 P52701 R1304F 1304 R F 0.938 Pathogenic MSH6 P52701 R1304G 1304 R G 0.142 Neutral MSH6 P52701 R1304H 1304 R H 0.412 Neutral MSH6 P52701 R1304I 1304 R I 0.768 Pathogenic MSH6 P52701 R1304K 1304 R K 0.028 Neutral 2 MSH6 P52701 R1304L 1304 R L 0.216 Neutral MSH6 P52701 R1304M 1304 R M 0.064 Neutral MSH6 P52701 R1304N 1304 R N 0.022 Neutral MSH6 P52701 R1304P 1304 R P 0.848 Pathogenic MSH6 P52701 R1304Q 1304 R Q 0.43 Neutral MSH6 P52701 R1304S 1304 R S 0.054 Neutral MSH6 P52701 R1304T 1304 R T 0.176 Neutral MSH6 P52701 R1304V 1304 R V 0.824 Pathogenic MSH6 P52701 R1304W 1304 R W 0.914 Pathogenic MSH6 P52701 R1304Y 1304 R Y 0.894 Pathogenic MSH6 P52701 L1305A 1305 L A 0.194 Neutral MSH6 P52701 L1305C 1305 L C 0.688 Pathogenic MSH6 P52701 L1305D 1305 L D 0.89 Pathogenic MSH6 P52701 L1305E 1305 L E 0.876 Pathogenic MSH6 P52701 L1305F 1305 L F 0.976 Pathogenic MSH6 P52701 L1305G 1305 L G 0.792 Pathogenic MSH6 P52701 L1305H 1305 L H 0.814 Pathogenic MSH6 P52701 L1305I 1305 L I 0.202 Neutral MSH6 P52701 L1305K 1305 L K 0.434 Neutral MSH6 P52701 L1305M 1305 L M 0.186 Neutral MSH6 P52701 L1305N 1305 L N 0.756 Pathogenic MSH6 P52701 L1305P 1305 L P 0.994 Pathogenic MSH6 P52701 L1305Q 1305 L Q 0.624 Pathogenic MSH6 P52701 L1305R 1305 L R 0.988 Pathogenic MSH6 P52701 L1305S 1305 L S 0.338 Neutral MSH6 P52701 L1305T 1305 L T 0.576 Pathogenic MSH6 P52701 L1305V 1305 L V 0.106 Neutral MSH6 P52701 L1305W 1305 L W 0.94 Pathogenic MSH6 P52701 L1305Y 1305 L Y 0.902 Pathogenic MSH6 P52701 A1306C 1306 A C 0.374 Neutral MSH6 P52701 A1306D 1306 A D 0.958 Pathogenic MSH6 P52701 A1306E 1306 A E 0.976 Pathogenic MSH6 P52701 A1306F 1306 A F 0.996 Pathogenic MSH6 P52701 A1306G 1306 A G 0.366 Neutral MSH6 P52701 A1306H 1306 A H 0.942 Pathogenic MSH6 P52701 A1306I 1306 A I 0.968 Pathogenic MSH6 P52701 A1306K 1306 A K 0.976 Pathogenic MSH6 P52701 A1306L 1306 A L 1 Pathogenic MSH6 P52701 A1306M 1306 A M 0.91 Pathogenic MSH6 P52701 A1306N 1306 A N 0.878 Pathogenic MSH6 P52701 A1306P 1306 A P 0.978 Pathogenic MSH6 P52701 A1306Q 1306 A Q 0.894 Pathogenic MSH6 P52701 A1306R 1306 A R 0.978 Pathogenic MSH6 P52701 A1306S 1306 A S 0.146 Neutral MSH6 P52701 A1306T 1306 A T 0.884 Pathogenic MSH6 P52701 A1306V 1306 A V 0.942 Pathogenic MSH6 P52701 A1306W 1306 A W 0.996 Pathogenic MSH6 P52701 A1306Y 1306 A Y 0.972 Pathogenic MSH6 P52701 N1307A 1307 N A 0.632 Pathogenic MSH6 P52701 N1307C 1307 N C 0.508 Pathogenic MSH6 P52701 N1307D 1307 N D 0.17 Neutral MSH6 P52701 N1307E 1307 N E 0.362 Neutral MSH6 P52701 N1307F 1307 N F 0.93 Pathogenic MSH6 P52701 N1307G 1307 N G 0.384 Neutral MSH6 P52701 N1307H 1307 N H 0.432 Neutral MSH6 P52701 N1307I 1307 N I 0.898 Pathogenic MSH6 P52701 N1307K 1307 N K 0.382 Neutral MSH6 P52701 N1307L 1307 N L 0.896 Pathogenic MSH6 P52701 N1307M 1307 N M 0.526 Pathogenic MSH6 P52701 N1307P 1307 N P 0.762 Pathogenic MSH6 P52701 N1307Q 1307 N Q 0.222 Neutral MSH6 P52701 N1307R 1307 N R 0.642 Pathogenic MSH6 P52701 N1307S 1307 N S 0.194 Neutral MSH6 P52701 N1307T 1307 N T 0.534 Pathogenic MSH6 P52701 N1307V 1307 N V 0.934 Pathogenic MSH6 P52701 N1307W 1307 N W 0.942 Pathogenic MSH6 P52701 N1307Y 1307 N Y 0.932 Pathogenic MSH6 P52701 L1308A 1308 L A 0.564 Pathogenic MSH6 P52701 L1308C 1308 L C 0.686 Pathogenic MSH6 P52701 L1308D 1308 L D 0.914 Pathogenic MSH6 P52701 L1308E 1308 L E 0.892 Pathogenic MSH6 P52701 L1308F 1308 L F 0.884 Pathogenic MSH6 P52701 L1308G 1308 L G 0.81 Pathogenic MSH6 P52701 L1308H 1308 L H 0.782 Pathogenic MSH6 P52701 L1308I 1308 L I 0.148 Neutral MSH6 P52701 L1308K 1308 L K 0.408 Neutral MSH6 P52701 L1308M 1308 L M 0.164 Neutral MSH6 P52701 L1308N 1308 L N 0.784 Pathogenic MSH6 P52701 L1308P 1308 L P 0.978 Pathogenic MSH6 P52701 L1308Q 1308 L Q 0.612 Pathogenic MSH6 P52701 L1308R 1308 L R 0.998 Pathogenic MSH6 P52701 L1308S 1308 L S 0.582 Pathogenic MSH6 P52701 L1308T 1308 L T 0.55 Pathogenic MSH6 P52701 L1308V 1308 L V 0.078 Neutral MSH6 P52701 L1308W 1308 L W 0.872 Pathogenic MSH6 P52701 L1308Y 1308 L Y 0.832 Pathogenic MSH6 P52701 P1309A 1309 P A 0.802 Pathogenic MSH6 P52701 P1309C 1309 P C 0.896 Pathogenic MSH6 P52701 P1309D 1309 P D 0.236 Neutral MSH6 P52701 P1309E 1309 P E 0.596 Pathogenic MSH6 P52701 P1309F 1309 P F 0.992 Pathogenic MSH6 P52701 P1309G 1309 P G 0.578 Pathogenic MSH6 P52701 P1309H 1309 P H 0.706 Pathogenic MSH6 P52701 P1309I 1309 P I 0.928 Pathogenic MSH6 P52701 P1309K 1309 P K 0.284 Neutral MSH6 P52701 P1309L 1309 P L 0.99 Pathogenic MSH6 P52701 P1309M 1309 P M 0.95 Pathogenic MSH6 P52701 P1309N 1309 P N 0.198 Neutral MSH6 P52701 P1309Q 1309 P Q 0.838 Pathogenic MSH6 P52701 P1309R 1309 P R 0.508 Pathogenic MSH6 P52701 P1309S 1309 P S 0.082 Neutral MSH6 P52701 P1309T 1309 P T 0.698 Pathogenic MSH6 P52701 P1309V 1309 P V 0.834 Pathogenic MSH6 P52701 P1309W 1309 P W 0.936 Pathogenic MSH6 P52701 P1309Y 1309 P Y 0.934 Pathogenic MSH6 P52701 V131A 131 V A 0.044 Neutral MSH6 P52701 V131C 131 V C 0.1 Neutral MSH6 P52701 V131D 131 V D 0.186 Neutral MSH6 P52701 V131E 131 V E 0.316 Neutral MSH6 P52701 V131F 131 V F 0.372 Neutral MSH6 P52701 V131G 131 V G 0.27 Neutral MSH6 P52701 V131H 131 V H 0.22 Neutral MSH6 P52701 V131I 131 V I 0.148 Neutral MSH6 P52701 V131K 131 V K 0.286 Neutral MSH6 P52701 V131L 131 V L 0.126 Neutral MSH6 P52701 V131M 131 V M 0.162 Neutral MSH6 P52701 V131N 131 V N 0.206 Neutral MSH6 P52701 V131P 131 V P 0.338 Neutral MSH6 P52701 V131Q 131 V Q 0.342 Neutral MSH6 P52701 V131R 131 V R 0.48 Neutral MSH6 P52701 V131S 131 V S 0.138 Neutral MSH6 P52701 V131T 131 V T 0.124 Neutral MSH6 P52701 V131W 131 V W 0.55 Pathogenic MSH6 P52701 V131Y 131 V Y 0.47 Neutral MSH6 P52701 E1310A 1310 E A 0.104 Neutral MSH6 P52701 E1310C 1310 E C 0.152 Neutral MSH6 P52701 E1310D 1310 E D 0.004 Neutral MSH6 P52701 E1310F 1310 E F 0.49 Neutral MSH6 P52701 E1310G 1310 E G 0.008 Neutral MSH6 P52701 E1310H 1310 E H 0.02 Neutral MSH6 P52701 E1310I 1310 E I 0.17 Neutral MSH6 P52701 E1310K 1310 E K 0.014 Neutral MSH6 P52701 E1310L 1310 E L 0.136 Neutral MSH6 P52701 E1310M 1310 E M 0.406 Neutral MSH6 P52701 E1310N 1310 E N 0.004 Neutral MSH6 P52701 E1310P 1310 E P 0.076 Neutral MSH6 P52701 E1310Q 1310 E Q 0.002 Neutral MSH6 P52701 E1310R 1310 E R 0.026 Neutral MSH6 P52701 E1310S 1310 E S 0.022 Neutral MSH6 P52701 E1310T 1310 E T 0.026 Neutral MSH6 P52701 E1310V 1310 E V 0.478 Neutral MSH6 P52701 E1310W 1310 E W 0.772 Pathogenic MSH6 P52701 E1310Y 1310 E Y 0.644 Pathogenic MSH6 P52701 E1311A 1311 E A 0.186 Neutral MSH6 P52701 E1311C 1311 E C 0.158 Neutral MSH6 P52701 E1311D 1311 E D 0.016 Neutral MSH6 P52701 E1311F 1311 E F 0.782 Pathogenic MSH6 P52701 E1311G 1311 E G 0.024 Neutral MSH6 P52701 E1311H 1311 E H 0.146 Neutral MSH6 P52701 E1311I 1311 E I 0.85 Pathogenic MSH6 P52701 E1311K 1311 E K 0.028 Neutral MSH6 P52701 E1311L 1311 E L 0.822 Pathogenic MSH6 P52701 E1311M 1311 E M 0.636 Pathogenic MSH6 P52701 E1311N 1311 E N 0.054 Neutral MSH6 P52701 E1311P 1311 E P 0.438 Neutral MSH6 P52701 E1311Q 1311 E Q 0.012 Neutral MSH6 P52701 E1311R 1311 E R 0.076 Neutral MSH6 P52701 E1311S 1311 E S 0.038 Neutral MSH6 P52701 E1311T 1311 E T 0.614 Pathogenic MSH6 P52701 E1311V 1311 E V 0.084 Neutral MSH6 P52701 E1311W 1311 E W 0.918 Pathogenic MSH6 P52701 E1311Y 1311 E Y 0.602 Pathogenic MSH6 P52701 V1312A 1312 V A 0.468 Neutral MSH6 P52701 V1312C 1312 V C 0.8 Pathogenic MSH6 P52701 V1312D 1312 V D 0.86 Pathogenic MSH6 P52701 V1312E 1312 V E 0.964 Pathogenic MSH6 P52701 V1312F 1312 V F 0.924 Pathogenic MSH6 P52701 V1312G 1312 V G 0.912 Pathogenic MSH6 P52701 V1312H 1312 V H 0.892 Pathogenic MSH6 P52701 V1312I 1312 V I 0.234 Neutral MSH6 P52701 V1312K 1312 V K 0.988 Pathogenic MSH6 P52701 V1312L 1312 V L 0.936 Pathogenic MSH6 P52701 V1312M 1312 V M 0.898 Pathogenic MSH6 P52701 V1312N 1312 V N 0.922 Pathogenic MSH6 P52701 V1312P 1312 V P 0.986 Pathogenic MSH6 P52701 V1312Q 1312 V Q 0.972 Pathogenic MSH6 P52701 V1312R 1312 V R 0.948 Pathogenic MSH6 P52701 V1312S 1312 V S 0.8 Pathogenic MSH6 P52701 V1312T 1312 V T 0.87 Pathogenic MSH6 P52701 V1312W 1312 V W 0.948 Pathogenic MSH6 P52701 V1312Y 1312 V Y 0.97 Pathogenic MSH6 P52701 I1313A 1313 I A 0.482 Neutral MSH6 P52701 I1313C 1313 I C 0.63 Pathogenic MSH6 P52701 I1313D 1313 I D 0.772 Pathogenic MSH6 P52701 I1313E 1313 I E 0.774 Pathogenic MSH6 P52701 I1313F 1313 I F 0.952 Pathogenic MSH6 P52701 I1313G 1313 I G 0.814 Pathogenic MSH6 P52701 I1313H 1313 I H 0.85 Pathogenic MSH6 P52701 I1313K 1313 I K 0.862 Pathogenic MSH6 P52701 I1313L 1313 I L 0.088 Neutral MSH6 P52701 I1313M 1313 I M 0.688 Pathogenic MSH6 P52701 I1313N 1313 I N 0.798 Pathogenic MSH6 P52701 I1313P 1313 I P 0.94 Pathogenic MSH6 P52701 I1313Q 1313 I Q 0.806 Pathogenic MSH6 P52701 I1313R 1313 I R 0.674 Pathogenic MSH6 P52701 I1313S 1313 I S 0.63 Pathogenic MSH6 P52701 I1313T 1313 I T 0.09 Neutral MSH6 P52701 I1313V 1313 I V 0.11 Neutral MSH6 P52701 I1313W 1313 I W 0.976 Pathogenic MSH6 P52701 I1313Y 1313 I Y 0.97 Pathogenic MSH6 P52701 Q1314A 1314 Q A 0.106 Neutral MSH6 P52701 Q1314C 1314 Q C 0.368 Neutral MSH6 P52701 Q1314D 1314 Q D 0.018 Neutral MSH6 P52701 Q1314E 1314 Q E 0.036 Neutral MSH6 P52701 Q1314F 1314 Q F 0.728 Pathogenic MSH6 P52701 Q1314G 1314 Q G 0.42 Neutral MSH6 P52701 Q1314H 1314 Q H 0.406 Neutral MSH6 P52701 Q1314I 1314 Q I 0.77 Pathogenic MSH6 P52701 Q1314K 1314 Q K 0.054 Neutral MSH6 P52701 Q1314L 1314 Q L 0.178 Neutral MSH6 P52701 Q1314M 1314 Q M 0.644 Pathogenic MSH6 P52701 Q1314N 1314 Q N 0.072 Neutral MSH6 P52701 Q1314P 1314 Q P 0.788 Pathogenic MSH6 P52701 Q1314R 1314 Q R 0.036 Neutral MSH6 P52701 Q1314S 1314 Q S 0.096 Neutral MSH6 P52701 Q1314T 1314 Q T 0.032 Neutral MSH6 P52701 Q1314V 1314 Q V 0.762 Pathogenic MSH6 P52701 Q1314W 1314 Q W 0.874 Pathogenic MSH6 P52701 Q1314Y 1314 Q Y 0.818 Pathogenic MSH6 P52701 K1315A 1315 K A 0.036 Neutral MSH6 P52701 K1315C 1315 K C 0.002 Neutral MSH6 P52701 K1315D 1315 K D 0.02 Neutral MSH6 P52701 K1315E 1315 K E 0.006 Neutral MSH6 P52701 K1315F 1315 K F 0.426 Neutral MSH6 P52701 K1315G 1315 K G 0.15 Neutral MSH6 P52701 K1315H 1315 K H 0.11 Neutral MSH6 P52701 K1315I 1315 K I 0.458 Neutral MSH6 P52701 K1315L 1315 K L 0.06 Neutral MSH6 P52701 K1315M 1315 K M 0.354 Neutral MSH6 P52701 K1315N 1315 K N 0.01 Neutral MSH6 P52701 K1315P 1315 K P 0.462 Neutral MSH6 P52701 K1315Q 1315 K Q 0.116 Neutral MSH6 P52701 K1315R 1315 K R 0.014 Neutral MSH6 P52701 K1315S 1315 K S 0.02 Neutral MSH6 P52701 K1315T 1315 K T 0.022 Neutral MSH6 P52701 K1315V 1315 K V 0.046 Neutral MSH6 P52701 K1315W 1315 K W 0.746 Pathogenic MSH6 P52701 K1315Y 1315 K Y 0.632 Pathogenic MSH6 P52701 G1316A 1316 G A 0.288 Neutral MSH6 P52701 G1316C 1316 G C 0.918 Pathogenic MSH6 P52701 G1316D 1316 G D 0.958 Pathogenic MSH6 P52701 G1316E 1316 G E 0.98 Pathogenic MSH6 P52701 G1316F 1316 G F 0.986 Pathogenic MSH6 P52701 G1316H 1316 G H 0.986 Pathogenic MSH6 P52701 G1316I 1316 G I 0.93 Pathogenic MSH6 P52701 G1316K 1316 G K 0.988 Pathogenic MSH6 P52701 G1316L 1316 G L 0.986 Pathogenic MSH6 P52701 G1316M 1316 G M 0.99 Pathogenic MSH6 P52701 G1316N 1316 G N 0.918 Pathogenic MSH6 P52701 G1316P 1316 G P 0.976 Pathogenic MSH6 P52701 G1316Q 1316 G Q 0.964 Pathogenic MSH6 P52701 G1316R 1316 G R 0.998 Pathogenic MSH6 P52701 G1316S 1316 G S 0.634 Pathogenic MSH6 P52701 G1316T 1316 G T 0.906 Pathogenic MSH6 P52701 G1316V 1316 G V 0.988 Pathogenic MSH6 P52701 G1316W 1316 G W 0.976 Pathogenic MSH6 P52701 G1316Y 1316 G Y 0.98 Pathogenic MSH6 P52701 H1317A 1317 H A 0.058 Neutral MSH6 P52701 H1317C 1317 H C 0.082 Neutral MSH6 P52701 H1317D 1317 H D 0.074 Neutral MSH6 P52701 H1317E 1317 H E 0 Neutral MSH6 P52701 H1317F 1317 H F 0.04 Neutral MSH6 P52701 H1317G 1317 H G 0.202 Neutral MSH6 P52701 H1317I 1317 H I 0.196 Neutral MSH6 P52701 H1317K 1317 H K 0.01 Neutral MSH6 P52701 H1317L 1317 H L 0.022 Neutral MSH6 P52701 H1317M 1317 H M 0.196 Neutral MSH6 P52701 H1317N 1317 H N 0.002 Neutral MSH6 P52701 H1317P 1317 H P 0.468 Neutral MSH6 P52701 H1317Q 1317 H Q 0.006 Neutral MSH6 P52701 H1317R 1317 H R 0 Neutral MSH6 P52701 H1317S 1317 H S 0.326 Neutral MSH6 P52701 H1317T 1317 H T 0.106 Neutral MSH6 P52701 H1317V 1317 H V 0.03 Neutral MSH6 P52701 H1317W 1317 H W 0.688 Pathogenic MSH6 P52701 H1317Y 1317 H Y 0.04 Neutral MSH6 P52701 R1318A 1318 R A 0.052 Neutral MSH6 P52701 R1318C 1318 R C 0.152 Neutral MSH6 P52701 R1318D 1318 R D 0.03 Neutral MSH6 P52701 R1318E 1318 R E 0.034 Neutral MSH6 P52701 R1318F 1318 R F 0.538 Pathogenic MSH6 P52701 R1318G 1318 R G 0.014 Neutral MSH6 P52701 R1318H 1318 R H 0.246 Neutral MSH6 P52701 R1318I 1318 R I 0.12 Neutral MSH6 P52701 R1318K 1318 R K 0.012 Neutral MSH6 P52701 R1318L 1318 R L 0.09 Neutral MSH6 P52701 R1318M 1318 R M 0.322 Neutral MSH6 P52701 R1318N 1318 R N 0.016 Neutral MSH6 P52701 R1318P 1318 R P 0.482 Neutral MSH6 P52701 R1318Q 1318 R Q 0.014 Neutral MSH6 P52701 R1318S 1318 R S 0.034 Neutral MSH6 P52701 R1318T 1318 R T 0.028 Neutral MSH6 P52701 R1318V 1318 R V 0.058 Neutral MSH6 P52701 R1318W 1318 R W 0.652 Pathogenic MSH6 P52701 R1318Y 1318 R Y 0.518 Pathogenic MSH6 P52701 K1319A 1319 K A 0.068 Neutral MSH6 P52701 K1319C 1319 K C 0.07 Neutral MSH6 P52701 K1319D 1319 K D 0.34 Neutral MSH6 P52701 K1319E 1319 K E 0.022 Neutral MSH6 P52701 K1319F 1319 K F 0.804 Pathogenic MSH6 P52701 K1319G 1319 K G 0.354 Neutral MSH6 P52701 K1319H 1319 K H 0.428 Neutral MSH6 P52701 K1319I 1319 K I 0.162 Neutral MSH6 P52701 K1319L 1319 K L 0.83 Pathogenic MSH6 P52701 K1319M 1319 K M 0.11 Neutral MSH6 P52701 K1319N 1319 K N 0.39 Neutral MSH6 P52701 K1319P 1319 K P 0.776 Pathogenic MSH6 P52701 K1319Q 1319 K Q 0.436 Neutral MSH6 P52701 K1319R 1319 K R 0.036 Neutral MSH6 P52701 K1319S 1319 K S 0.39 Neutral MSH6 P52701 K1319T 1319 K T 0.024 Neutral MSH6 P52701 K1319V 1319 K V 0.338 Neutral MSH6 P52701 K1319W 1319 K W 0.944 Pathogenic MSH6 P52701 K1319Y 1319 K Y 0.894 Pathogenic MSH6 P52701 Q132A 132 Q A 0.184 Neutral MSH6 P52701 Q132C 132 Q C 0.16 Neutral MSH6 P52701 Q132D 132 Q D 0.142 Neutral MSH6 P52701 Q132E 132 Q E 0.15 Neutral MSH6 P52701 Q132F 132 Q F 0.426 Neutral MSH6 P52701 Q132G 132 Q G 0.184 Neutral MSH6 P52701 Q132H 132 Q H 0.036 Neutral MSH6 P52701 Q132I 132 Q I 0.446 Neutral MSH6 P52701 Q132K 132 Q K 0.352 Neutral MSH6 P52701 Q132L 132 Q L 0.394 Neutral MSH6 P52701 Q132M 132 Q M 0.332 Neutral MSH6 P52701 Q132N 132 Q N 0.156 Neutral MSH6 P52701 Q132P 132 Q P 0.46 Neutral MSH6 P52701 Q132R 132 Q R 0.146 Neutral MSH6 P52701 Q132S 132 Q S 0.268 Neutral MSH6 P52701 Q132T 132 Q T 0.2 Neutral MSH6 P52701 Q132V 132 Q V 0.43 Neutral MSH6 P52701 Q132W 132 Q W 0.684 Pathogenic MSH6 P52701 Q132Y 132 Q Y 0.612 Pathogenic MSH6 P52701 A1320C 1320 A C 0.974 Pathogenic MSH6 P52701 A1320D 1320 A D 0.958 Pathogenic MSH6 P52701 A1320E 1320 A E 0.976 Pathogenic MSH6 P52701 A1320F 1320 A F 0.994 Pathogenic MSH6 P52701 A1320G 1320 A G 0.134 Neutral MSH6 P52701 A1320H 1320 A H 0.942 Pathogenic MSH6 P52701 A1320I 1320 A I 0.964 Pathogenic MSH6 P52701 A1320K 1320 A K 0.864 Pathogenic MSH6 P52701 A1320L 1320 A L 1 Pathogenic MSH6 P52701 A1320M 1320 A M 0.908 Pathogenic MSH6 P52701 A1320N 1320 A N 0.88 Pathogenic MSH6 P52701 A1320P 1320 A P 0.974 Pathogenic MSH6 P52701 A1320Q 1320 A Q 0.902 Pathogenic MSH6 P52701 A1320R 1320 A R 0.982 Pathogenic MSH6 P52701 A1320S 1320 A S 0.136 Neutral MSH6 P52701 A1320T 1320 A T 0.434 Neutral MSH6 P52701 A1320V 1320 A V 0.928 Pathogenic MSH6 P52701 A1320W 1320 A W 0.996 Pathogenic MSH6 P52701 A1320Y 1320 A Y 0.97 Pathogenic MSH6 P52701 R1321A 1321 R A 0.106 Neutral MSH6 P52701 R1321C 1321 R C 0.618 Pathogenic MSH6 P52701 R1321D 1321 R D 0.608 Pathogenic MSH6 P52701 R1321E 1321 R E 0.04 Neutral MSH6 P52701 R1321F 1321 R F 0.228 Neutral MSH6 P52701 R1321G 1321 R G 0.31 Neutral MSH6 P52701 R1321H 1321 R H 0.018 Neutral MSH6 P52701 R1321I 1321 R I 0.2 Neutral MSH6 P52701 R1321K 1321 R K 0.042 Neutral MSH6 P52701 R1321L 1321 R L 0.206 Neutral MSH6 P52701 R1321M 1321 R M 0.346 Neutral MSH6 P52701 R1321N 1321 R N 0.022 Neutral MSH6 P52701 R1321P 1321 R P 0.778 Pathogenic MSH6 P52701 R1321Q 1321 R Q 0.026 Neutral MSH6 P52701 R1321S 1321 R S 0.038 Neutral MSH6 P52701 R1321T 1321 R T 0.268 Neutral MSH6 P52701 R1321V 1321 R V 0.404 Neutral MSH6 P52701 R1321W 1321 R W 0.844 Pathogenic MSH6 P52701 R1321Y 1321 R Y 0.116 Neutral MSH6 P52701 E1322A 1322 E A 0.218 Neutral MSH6 P52701 E1322C 1322 E C 0.33 Neutral MSH6 P52701 E1322D 1322 E D 0.014 Neutral MSH6 P52701 E1322F 1322 E F 0.876 Pathogenic MSH6 P52701 E1322G 1322 E G 0.214 Neutral MSH6 P52701 E1322H 1322 E H 0.058 Neutral MSH6 P52701 E1322I 1322 E I 0.838 Pathogenic MSH6 P52701 E1322K 1322 E K 0.042 Neutral MSH6 P52701 E1322L 1322 E L 0.242 Neutral MSH6 P52701 E1322M 1322 E M 0.634 Pathogenic MSH6 P52701 E1322N 1322 E N 0.034 Neutral MSH6 P52701 E1322P 1322 E P 0.888 Pathogenic MSH6 P52701 E1322Q 1322 E Q 0.01 Neutral MSH6 P52701 E1322R 1322 E R 0.596 Pathogenic MSH6 P52701 E1322S 1322 E S 0.062 Neutral MSH6 P52701 E1322T 1322 E T 0.492 Neutral MSH6 P52701 E1322V 1322 E V 0.406 Neutral MSH6 P52701 E1322W 1322 E W 0.964 Pathogenic MSH6 P52701 E1322Y 1322 E Y 0.884 Pathogenic MSH6 P52701 F1323A 1323 F A 0.27 Neutral MSH6 P52701 F1323C 1323 F C 0.324 Neutral MSH6 P52701 F1323D 1323 F D 0.56 Pathogenic MSH6 P52701 F1323E 1323 F E 0.66 Pathogenic MSH6 P52701 F1323G 1323 F G 0.354 Neutral MSH6 P52701 F1323H 1323 F H 0.374 Neutral MSH6 P52701 F1323I 1323 F I 0.06 Neutral MSH6 P52701 F1323K 1323 F K 0.608 Pathogenic MSH6 P52701 F1323L 1323 F L 0.032 Neutral MSH6 P52701 F1323M 1323 F M 0.04 Neutral MSH6 P52701 F1323N 1323 F N 0.546 Pathogenic MSH6 P52701 F1323P 1323 F P 0.702 Pathogenic MSH6 P52701 F1323Q 1323 F Q 0.448 Neutral MSH6 P52701 F1323R 1323 F R 0.652 Pathogenic MSH6 P52701 F1323S 1323 F S 0.422 Neutral MSH6 P52701 F1323T 1323 F T 0.344 Neutral MSH6 P52701 F1323V 1323 F V 0.428 Neutral MSH6 P52701 F1323W 1323 F W 0.584 Pathogenic MSH6 P52701 F1323Y 1323 F Y 0.476 Neutral MSH6 P52701 E1324A 1324 E A 0.282 Neutral MSH6 P52701 E1324C 1324 E C 0.682 Pathogenic MSH6 P52701 E1324D 1324 E D 0.264 Neutral MSH6 P52701 E1324F 1324 E F 0.51 Pathogenic MSH6 P52701 E1324G 1324 E G 0.372 Neutral MSH6 P52701 E1324H 1324 E H 0.844 Pathogenic MSH6 P52701 E1324I 1324 E I 0.968 Pathogenic MSH6 P52701 E1324K 1324 E K 0.95 Pathogenic MSH6 P52701 E1324L 1324 E L 0.962 Pathogenic MSH6 P52701 E1324M 1324 E M 0.898 Pathogenic MSH6 P52701 E1324N 1324 E N 0.686 Pathogenic MSH6 P52701 E1324P 1324 E P 0.918 Pathogenic MSH6 P52701 E1324Q 1324 E Q 0.282 Neutral MSH6 P52701 E1324R 1324 E R 0.88 Pathogenic MSH6 P52701 E1324S 1324 E S 0.15 Neutral MSH6 P52701 E1324T 1324 E T 0.852 Pathogenic MSH6 P52701 E1324V 1324 E V 0.904 Pathogenic MSH6 P52701 E1324W 1324 E W 0.984 Pathogenic MSH6 P52701 E1324Y 1324 E Y 0.966 Pathogenic MSH6 P52701 K1325A 1325 K A 0.032 Neutral MSH6 P52701 K1325C 1325 K C 0.05 Neutral MSH6 P52701 K1325D 1325 K D 0.014 Neutral MSH6 P52701 K1325E 1325 K E 0.004 Neutral MSH6 P52701 K1325F 1325 K F 0.38 Neutral MSH6 P52701 K1325G 1325 K G 0.07 Neutral MSH6 P52701 K1325H 1325 K H 0 Neutral MSH6 P52701 K1325I 1325 K I 0.068 Neutral MSH6 P52701 K1325L 1325 K L 0.368 Neutral MSH6 P52701 K1325M 1325 K M 0.168 Neutral MSH6 P52701 K1325N 1325 K N 0.054 Neutral MSH6 P52701 K1325P 1325 K P 0.378 Neutral MSH6 P52701 K1325Q 1325 K Q 0.01 Neutral MSH6 P52701 K1325R 1325 K R 0.006 Neutral MSH6 P52701 K1325S 1325 K S 0.014 Neutral MSH6 P52701 K1325T 1325 K T 0.014 Neutral MSH6 P52701 K1325V 1325 K V 0.282 Neutral MSH6 P52701 K1325W 1325 K W 0.662 Pathogenic MSH6 P52701 K1325Y 1325 K Y 0.576 Pathogenic MSH6 P52701 M1326A 1326 M A 0.046 Neutral MSH6 P52701 M1326C 1326 M C 0.05 Neutral MSH6 P52701 M1326D 1326 M D 0.08 Neutral MSH6 P52701 M1326E 1326 M E 0.016 Neutral MSH6 P52701 M1326F 1326 M F 0.036 Neutral MSH6 P52701 M1326G 1326 M G 0.146 Neutral MSH6 P52701 M1326H 1326 M H 0.034 Neutral MSH6 P52701 M1326I 1326 M I 0.006 Neutral MSH6 P52701 M1326K 1326 M K 0.018 Neutral MSH6 P52701 M1326L 1326 M L 0.006 Neutral MSH6 P52701 M1326N 1326 M N 0.078 Neutral MSH6 P52701 M1326P 1326 M P 0.312 Neutral MSH6 P52701 M1326Q 1326 M Q 0.006 Neutral MSH6 P52701 M1326R 1326 M R 0.054 Neutral MSH6 P52701 M1326S 1326 M S 0.012 Neutral MSH6 P52701 M1326T 1326 M T 0.008 Neutral MSH6 P52701 M1326V 1326 M V 0.018 Neutral MSH6 P52701 M1326W 1326 M W 0.528 Pathogenic MSH6 P52701 M1326Y 1326 M Y 0.446 Neutral MSH6 P52701 N1327A 1327 N A 0.012 Neutral MSH6 P52701 N1327C 1327 N C 0.25 Neutral MSH6 P52701 N1327D 1327 N D 0.15 Neutral MSH6 P52701 N1327E 1327 N E 0.166 Neutral MSH6 P52701 N1327F 1327 N F 0.594 Pathogenic MSH6 P52701 N1327G 1327 N G 0.052 Neutral MSH6 P52701 N1327H 1327 N H 0.176 Neutral MSH6 P52701 N1327I 1327 N I 0.294 Neutral MSH6 P52701 N1327K 1327 N K 0.192 Neutral MSH6 P52701 N1327L 1327 N L 0.098 Neutral MSH6 P52701 N1327M 1327 N M 0.054 Neutral MSH6 P52701 N1327P 1327 N P 0.4 Neutral MSH6 P52701 N1327Q 1327 N Q 0.192 Neutral MSH6 P52701 N1327R 1327 N R 0.36 Neutral MSH6 P52701 N1327S 1327 N S 0.004 Neutral MSH6 P52701 N1327T 1327 N T 0.012 Neutral MSH6 P52701 N1327V 1327 N V 0.044 Neutral MSH6 P52701 N1327W 1327 N W 0.724 Pathogenic MSH6 P52701 N1327Y 1327 N Y 0.528 Pathogenic MSH6 P52701 Q1328A 1328 Q A 0.138 Neutral MSH6 P52701 Q1328C 1328 Q C 0.084 Neutral MSH6 P52701 Q1328D 1328 Q D 0.046 Neutral MSH6 P52701 Q1328E 1328 Q E 0.006 Neutral MSH6 P52701 Q1328F 1328 Q F 0.284 Neutral MSH6 P52701 Q1328G 1328 Q G 0.032 Neutral MSH6 P52701 Q1328H 1328 Q H 0.034 Neutral MSH6 P52701 Q1328I 1328 Q I 0.244 Neutral MSH6 P52701 Q1328K 1328 Q K 0.02 Neutral MSH6 P52701 Q1328L 1328 Q L 0.122 Neutral MSH6 P52701 Q1328M 1328 Q M 0.218 Neutral MSH6 P52701 Q1328N 1328 Q N 0.018 Neutral MSH6 P52701 Q1328P 1328 Q P 0.314 Neutral MSH6 P52701 Q1328R 1328 Q R 0.002 Neutral MSH6 P52701 Q1328S 1328 Q S 0.186 Neutral MSH6 P52701 Q1328T 1328 Q T 0.002 Neutral MSH6 P52701 Q1328V 1328 Q V 0.018 Neutral MSH6 P52701 Q1328W 1328 Q W 0.49 Neutral MSH6 P52701 Q1328Y 1328 Q Y 0.424 Neutral MSH6 P52701 S1329A 1329 S A 0.012 Neutral MSH6 P52701 S1329C 1329 S C 0.05 Neutral MSH6 P52701 S1329D 1329 S D 0.078 Neutral MSH6 P52701 S1329E 1329 S E 0.236 Neutral MSH6 P52701 S1329F 1329 S F 0.504 Pathogenic MSH6 P52701 S1329G 1329 S G 0.064 Neutral MSH6 P52701 S1329H 1329 S H 0.358 Neutral MSH6 P52701 S1329I 1329 S I 0.156 Neutral MSH6 P52701 S1329K 1329 S K 0.252 Neutral MSH6 P52701 S1329L 1329 S L 0.05 Neutral 2 MSH6 P52701 S1329M 1329 S M 0.368 Neutral MSH6 P52701 S1329N 1329 S N 0.008 Neutral MSH6 P52701 S1329P 1329 S P 0.2 Neutral MSH6 P52701 S1329Q 1329 S Q 0.27 Neutral MSH6 P52701 S1329R 1329 S R 0.248 Neutral MSH6 P52701 S1329T 1329 S T 0.06 Neutral MSH6 P52701 S1329V 1329 S V 0.056 Neutral MSH6 P52701 S1329W 1329 S W 0.728 Pathogenic MSH6 P52701 S1329Y 1329 S Y 0.688 Pathogenic MSH6 P52701 F133A 133 F A 0.12 Neutral MSH6 P52701 F133C 133 F C 0.124 Neutral MSH6 P52701 F133D 133 F D 0.224 Neutral MSH6 P52701 F133E 133 F E 0.264 Neutral MSH6 P52701 F133G 133 F G 0.184 Neutral MSH6 P52701 F133H 133 F H 0.1 Neutral MSH6 P52701 F133I 133 F I 0.132 Neutral MSH6 P52701 F133K 133 F K 0.25 Neutral MSH6 P52701 F133L 133 F L 0.102 Neutral MSH6 P52701 F133M 133 F M 0.118 Neutral MSH6 P52701 F133N 133 F N 0.244 Neutral MSH6 P52701 F133P 133 F P 0.26 Neutral MSH6 P52701 F133Q 133 F Q 0.244 Neutral MSH6 P52701 F133R 133 F R 0.212 Neutral MSH6 P52701 F133S 133 F S 0.206 Neutral MSH6 P52701 F133T 133 F T 0.226 Neutral MSH6 P52701 F133V 133 F V 0.222 Neutral MSH6 P52701 F133W 133 F W 0.45 Neutral MSH6 P52701 F133Y 133 F Y 0.156 Neutral MSH6 P52701 L1330A 1330 L A 0.074 Neutral MSH6 P52701 L1330C 1330 L C 0.06 Neutral MSH6 P52701 L1330D 1330 L D 0.23 Neutral MSH6 P52701 L1330E 1330 L E 0.044 Neutral MSH6 P52701 L1330F 1330 L F 0.168 Neutral MSH6 P52701 L1330G 1330 L G 0.242 Neutral MSH6 P52701 L1330H 1330 L H 0.034 Neutral MSH6 P52701 L1330I 1330 L I 0.004 Neutral MSH6 P52701 L1330K 1330 L K 0.026 Neutral MSH6 P52701 L1330M 1330 L M 0.016 Neutral MSH6 P52701 L1330N 1330 L N 0.104 Neutral MSH6 P52701 L1330P 1330 L P 0.334 Neutral MSH6 P52701 L1330Q 1330 L Q 0.1 Neutral MSH6 P52701 L1330R 1330 L R 0.342 Neutral MSH6 P52701 L1330S 1330 L S 0.256 Neutral MSH6 P52701 L1330T 1330 L T 0.238 Neutral MSH6 P52701 L1330V 1330 L V 0.23 Neutral MSH6 P52701 L1330W 1330 L W 0.526 Pathogenic MSH6 P52701 L1330Y 1330 L Y 0.496 Neutral MSH6 P52701 R1331A 1331 R A 0.038 Neutral MSH6 P52701 R1331C 1331 R C 0.226 Neutral MSH6 P52701 R1331D 1331 R D 0.022 Neutral MSH6 P52701 R1331E 1331 R E 0.028 Neutral MSH6 P52701 R1331F 1331 R F 0.426 Neutral MSH6 P52701 R1331G 1331 R G 0.124 Neutral MSH6 P52701 R1331H 1331 R H 0.008 Neutral MSH6 P52701 R1331I 1331 R I 0.44 Neutral MSH6 P52701 R1331K 1331 R K 0.008 Neutral MSH6 P52701 R1331L 1331 R L 0.408 Neutral MSH6 P52701 R1331M 1331 R M 0.232 Neutral MSH6 P52701 R1331N 1331 R N 0.236 Neutral MSH6 P52701 R1331P 1331 R P 0.392 Neutral MSH6 P52701 R1331Q 1331 R Q 0.014 Neutral MSH6 P52701 R1331S 1331 R S 0.02 Neutral MSH6 P52701 R1331T 1331 R T 0.028 Neutral MSH6 P52701 R1331V 1331 R V 0.282 Neutral MSH6 P52701 R1331W 1331 R W 0.59 Pathogenic MSH6 P52701 R1331Y 1331 R Y 0.426 Neutral MSH6 P52701 L1332A 1332 L A 0.03 Neutral MSH6 P52701 L1332C 1332 L C 0.01 Neutral MSH6 P52701 L1332D 1332 L D 0.25 Neutral MSH6 P52701 L1332E 1332 L E 0.232 Neutral MSH6 P52701 L1332F 1332 L F 0.292 Neutral MSH6 P52701 L1332G 1332 L G 0.25 Neutral MSH6 P52701 L1332H 1332 L H 0.072 Neutral MSH6 P52701 L1332I 1332 L I 0.002 Neutral MSH6 P52701 L1332K 1332 L K 0.028 Neutral MSH6 P52701 L1332M 1332 L M 0.094 Neutral MSH6 P52701 L1332N 1332 L N 0.042 Neutral MSH6 P52701 L1332P 1332 L P 0.356 Neutral MSH6 P52701 L1332Q 1332 L Q 0.032 Neutral MSH6 P52701 L1332R 1332 L R 0.34 Neutral MSH6 P52701 L1332S 1332 L S 0.016 Neutral MSH6 P52701 L1332T 1332 L T 0.178 Neutral MSH6 P52701 L1332V 1332 L V 0.24 Neutral MSH6 P52701 L1332W 1332 L W 0.536 Pathogenic MSH6 P52701 L1332Y 1332 L Y 0.498 Neutral MSH6 P52701 F1333A 1333 F A 0.132 Neutral MSH6 P52701 F1333C 1333 F C 0.094 Neutral MSH6 P52701 F1333D 1333 F D 0.244 Neutral MSH6 P52701 F1333E 1333 F E 0.28 Neutral MSH6 P52701 F1333G 1333 F G 0.198 Neutral MSH6 P52701 F1333H 1333 F H 0.054 Neutral MSH6 P52701 F1333I 1333 F I 0.094 Neutral MSH6 P52701 F1333K 1333 F K 0.074 Neutral MSH6 P52701 F1333L 1333 F L 0.004 Neutral MSH6 P52701 F1333M 1333 F M 0.032 Neutral MSH6 P52701 F1333N 1333 F N 0.256 Neutral MSH6 P52701 F1333P 1333 F P 0.274 Neutral MSH6 P52701 F1333Q 1333 F Q 0.048 Neutral MSH6 P52701 F1333R 1333 F R 0.236 Neutral MSH6 P52701 F1333S 1333 F S 0.034 Neutral MSH6 P52701 F1333T 1333 F T 0.288 Neutral MSH6 P52701 F1333V 1333 F V 0.012 Neutral MSH6 P52701 F1333W 1333 F W 0.462 Neutral MSH6 P52701 F1333Y 1333 F Y 0.232 Neutral MSH6 P52701 R1334A 1334 R A 0.054 Neutral MSH6 P52701 R1334C 1334 R C 0.244 Neutral MSH6 P52701 R1334D 1334 R D 0.02 Neutral MSH6 P52701 R1334E 1334 R E 0.03 Neutral MSH6 P52701 R1334F 1334 R F 0.47 Neutral MSH6 P52701 R1334G 1334 R G 0.098 Neutral MSH6 P52701 R1334H 1334 R H 0.248 Neutral MSH6 P52701 R1334I 1334 R I 0.498 Neutral MSH6 P52701 R1334K 1334 R K 0.006 Neutral MSH6 P52701 R1334L 1334 R L 0.454 Neutral MSH6 P52701 R1334M 1334 R M 0.258 Neutral MSH6 P52701 R1334N 1334 R N 0.262 Neutral MSH6 P52701 R1334P 1334 R P 0.43 Neutral MSH6 P52701 R1334Q 1334 R Q 0.242 Neutral MSH6 P52701 R1334S 1334 R S 0.252 Neutral MSH6 P52701 R1334T 1334 R T 0.272 Neutral MSH6 P52701 R1334V 1334 R V 0.176 Neutral MSH6 P52701 R1334W 1334 R W 0.62 Pathogenic MSH6 P52701 R1334Y 1334 R Y 0.464 Neutral MSH6 P52701 E1335A 1335 E A 0.118 Neutral MSH6 P52701 E1335C 1335 E C 0.068 Neutral MSH6 P52701 E1335D 1335 E D 0 Neutral MSH6 P52701 E1335F 1335 E F 0.324 Neutral MSH6 P52701 E1335G 1335 E G 0.054 Neutral MSH6 P52701 E1335H 1335 E H 0.018 Neutral MSH6 P52701 E1335I 1335 E I 0.294 Neutral MSH6 P52701 E1335K 1335 E K 0.002 Neutral MSH6 P52701 E1335L 1335 E L 0.3 Neutral MSH6 P52701 E1335M 1335 E M 0.172 Neutral MSH6 P52701 E1335N 1335 E N 0.036 Neutral MSH6 P52701 E1335P 1335 E P 0.308 Neutral MSH6 P52701 E1335Q 1335 E Q 0 Neutral MSH6 P52701 E1335R 1335 E R 0.01 Neutral MSH6 P52701 E1335S 1335 E S 0.014 Neutral MSH6 P52701 E1335T 1335 E T 0.082 Neutral MSH6 P52701 E1335V 1335 E V 0.258 Neutral MSH6 P52701 E1335W 1335 E W 0.448 Neutral MSH6 P52701 E1335Y 1335 E Y 0.234 Neutral MSH6 P52701 V1336A 1336 V A 0.004 Neutral MSH6 P52701 V1336C 1336 V C 0.104 Neutral MSH6 P52701 V1336D 1336 V D 0.19 Neutral MSH6 P52701 V1336E 1336 V E 0.28 Neutral MSH6 P52701 V1336F 1336 V F 0.308 Neutral MSH6 P52701 V1336G 1336 V G 0.276 Neutral MSH6 P52701 V1336H 1336 V H 0.226 Neutral MSH6 P52701 V1336I 1336 V I 0.008 Neutral MSH6 P52701 V1336K 1336 V K 0.164 Neutral MSH6 P52701 V1336L 1336 V L 0.004 Neutral MSH6 P52701 V1336M 1336 V M 0.17 Neutral MSH6 P52701 V1336N 1336 V N 0.216 Neutral MSH6 P52701 V1336P 1336 V P 0.334 Neutral MSH6 P52701 V1336Q 1336 V Q 0.352 Neutral MSH6 P52701 V1336R 1336 V R 0.42 Neutral MSH6 P52701 V1336S 1336 V S 0.142 Neutral MSH6 P52701 V1336T 1336 V T 0.068 Neutral MSH6 P52701 V1336W 1336 V W 0.536 Pathogenic MSH6 P52701 V1336Y 1336 V Y 0.454 Neutral MSH6 P52701 C1337A 1337 C A 0.078 Neutral MSH6 P52701 C1337D 1337 C D 0.064 Neutral MSH6 P52701 C1337E 1337 C E 0.136 Neutral MSH6 P52701 C1337F 1337 C F 0.34 Neutral MSH6 P52701 C1337G 1337 C G 0.162 Neutral MSH6 P52701 C1337H 1337 C H 0.232 Neutral MSH6 P52701 C1337I 1337 C I 0.364 Neutral MSH6 P52701 C1337K 1337 C K 0.032 Neutral MSH6 P52701 C1337L 1337 C L 0.316 Neutral MSH6 P52701 C1337M 1337 C M 0.048 Neutral MSH6 P52701 C1337N 1337 C N 0.01 Neutral MSH6 P52701 C1337P 1337 C P 0.29 Neutral MSH6 P52701 C1337Q 1337 C Q 0.148 Neutral MSH6 P52701 C1337R 1337 C R 0.242 Neutral MSH6 P52701 C1337S 1337 C S 0.176 Neutral MSH6 P52701 C1337T 1337 C T 0 Neutral MSH6 P52701 C1337V 1337 C V 0.206 Neutral MSH6 P52701 C1337W 1337 C W 0.538 Pathogenic MSH6 P52701 C1337Y 1337 C Y 0.488 Neutral MSH6 P52701 L1338A 1338 L A 0.008 Neutral MSH6 P52701 L1338C 1338 L C 0.056 Neutral MSH6 P52701 L1338D 1338 L D 0.158 Neutral MSH6 P52701 L1338E 1338 L E 0.038 Neutral MSH6 P52701 L1338F 1338 L F 0.242 Neutral MSH6 P52701 L1338G 1338 L G 0.186 Neutral MSH6 P52701 L1338H 1338 L H 0.084 Neutral MSH6 P52701 L1338I 1338 L I 0.004 Neutral MSH6 P52701 L1338K 1338 L K 0.084 Neutral MSH6 P52701 L1338M 1338 L M 0.032 Neutral MSH6 P52701 L1338N 1338 L N 0.074 Neutral MSH6 P52701 L1338P 1338 L P 0.216 Neutral MSH6 P52701 L1338Q 1338 L Q 0.004 Neutral MSH6 P52701 L1338R 1338 L R 0.234 Neutral MSH6 P52701 L1338S 1338 L S 0.01 Neutral MSH6 P52701 L1338T 1338 L T 0.012 Neutral MSH6 P52701 L1338V 1338 L V 0.114 Neutral MSH6 P52701 L1338W 1338 L W 0.27 Neutral MSH6 P52701 L1338Y 1338 L Y 0.284 Neutral MSH6 P52701 A1339C 1339 A C 0.182 Neutral MSH6 P52701 A1339D 1339 A D 0.326 Neutral MSH6 P52701 A1339E 1339 A E 0.306 Neutral MSH6 P52701 A1339F 1339 A F 0.3 Neutral MSH6 P52701 A1339G 1339 A G 0.004 Neutral MSH6 P52701 A1339H 1339 A H 0.304 Neutral MSH6 P52701 A1339I 1339 A I 0.356 Neutral MSH6 P52701 A1339K 1339 A K 0.276 Neutral MSH6 P52701 A1339L 1339 A L 0.316 Neutral MSH6 P52701 A1339M 1339 A M 0.29 Neutral MSH6 P52701 A1339N 1339 A N 0.296 Neutral MSH6 P52701 A1339P 1339 A P 0.272 Neutral MSH6 P52701 A1339Q 1339 A Q 0.302 Neutral MSH6 P52701 A1339R 1339 A R 0.318 Neutral MSH6 P52701 A1339S 1339 A S 0.008 Neutral MSH6 P52701 A1339T 1339 A T 0.03 Neutral MSH6 P52701 A1339V 1339 A V 0.042 Neutral MSH6 P52701 A1339W 1339 A W 0.504 Pathogenic MSH6 P52701 A1339Y 1339 A Y 0.5 Pathogenic MSH6 P52701 F134A 134 F A 0.12 Neutral MSH6 P52701 F134C 134 F C 0.126 Neutral MSH6 P52701 F134D 134 F D 0.232 Neutral MSH6 P52701 F134E 134 F E 0.272 Neutral MSH6 P52701 F134G 134 F G 0.188 Neutral MSH6 P52701 F134H 134 F H 0.104 Neutral MSH6 P52701 F134I 134 F I 0.13 Neutral MSH6 P52701 F134K 134 F K 0.258 Neutral MSH6 P52701 F134L 134 F L 0.104 Neutral MSH6 P52701 F134M 134 F M 0.12 Neutral MSH6 P52701 F134N 134 F N 0.25 Neutral MSH6 P52701 F134P 134 F P 0.266 Neutral MSH6 P52701 F134Q 134 F Q 0.25 Neutral MSH6 P52701 F134R 134 F R 0.22 Neutral MSH6 P52701 F134S 134 F S 0.212 Neutral MSH6 P52701 F134T 134 F T 0.23 Neutral MSH6 P52701 F134V 134 F V 0.276 Neutral MSH6 P52701 F134W 134 F W 0.456 Neutral MSH6 P52701 F134Y 134 F Y 0.054 Neutral MSH6 P52701 S1340A 1340 S A 0.01 Neutral MSH6 P52701 S1340C 1340 S C 0.002 Neutral MSH6 P52701 S1340D 1340 S D 0.024 Neutral MSH6 P52701 S1340E 1340 S E 0.114 Neutral MSH6 P52701 S1340F 1340 S F 0.264 Neutral MSH6 P52701 S1340G 1340 S G 0.066 Neutral MSH6 P52701 S1340H 1340 S H 0.238 Neutral MSH6 P52701 S1340I 1340 S I 0.196 Neutral MSH6 P52701 S1340K 1340 S K 0.164 Neutral MSH6 P52701 S1340L 1340 S L 0.026 Neutral MSH6 P52701 S1340M 1340 S M 0.28 Neutral MSH6 P52701 S1340N 1340 S N 0.012 Neutral MSH6 P52701 S1340P 1340 S P 0.116 Neutral MSH6 P52701 S1340Q 1340 S Q 0.158 Neutral MSH6 P52701 S1340R 1340 S R 0.248 Neutral MSH6 P52701 S1340T 1340 S T 0.02 Neutral MSH6 P52701 S1340V 1340 S V 0.034 Neutral MSH6 P52701 S1340W 1340 S W 0.49 Neutral MSH6 P52701 S1340Y 1340 S Y 0.448 Neutral MSH6 P52701 E1341A 1341 E A 0.212 Neutral MSH6 P52701 E1341C 1341 E C 0.014 Neutral MSH6 P52701 E1341D 1341 E D 0 Neutral MSH6 P52701 E1341F 1341 E F 0.312 Neutral MSH6 P52701 E1341G 1341 E G 0.002 Neutral MSH6 P52701 E1341H 1341 E H 0.104 Neutral MSH6 P52701 E1341I 1341 E I 0.284 Neutral MSH6 P52701 E1341K 1341 E K 0.144 Neutral MSH6 P52701 E1341L 1341 E L 0.042 Neutral MSH6 P52701 E1341M 1341 E M 0.164 Neutral MSH6 P52701 E1341N 1341 E N 0.036 Neutral MSH6 P52701 E1341P 1341 E P 0.3 Neutral MSH6 P52701 E1341Q 1341 E Q 0.056 Neutral MSH6 P52701 E1341R 1341 E R 0.046 Neutral MSH6 P52701 E1341S 1341 E S 0.058 Neutral MSH6 P52701 E1341T 1341 E T 0.168 Neutral MSH6 P52701 E1341V 1341 E V 0.038 Neutral MSH6 P52701 E1341W 1341 E W 0.43 Neutral MSH6 P52701 E1341Y 1341 E Y 0.296 Neutral MSH6 P52701 R1342A 1342 R A 0.036 Neutral MSH6 P52701 R1342C 1342 R C 0.148 Neutral MSH6 P52701 R1342D 1342 R D 0.02 Neutral MSH6 P52701 R1342E 1342 R E 0.162 Neutral MSH6 P52701 R1342F 1342 R F 0.28 Neutral MSH6 P52701 R1342G 1342 R G 0.002 Neutral MSH6 P52701 R1342H 1342 R H 0.12 Neutral MSH6 P52701 R1342I 1342 R I 0.116 Neutral MSH6 P52701 R1342K 1342 R K 0.004 Neutral MSH6 P52701 R1342L 1342 R L 0.026 Neutral MSH6 P52701 R1342M 1342 R M 0.164 Neutral MSH6 P52701 R1342N 1342 R N 0.01 Neutral MSH6 P52701 R1342P 1342 R P 0.236 Neutral MSH6 P52701 R1342Q 1342 R Q 0.25 Neutral MSH6 P52701 R1342S 1342 R S 0.164 Neutral MSH6 P52701 R1342T 1342 R T 0.016 Neutral MSH6 P52701 R1342V 1342 R V 0.056 Neutral MSH6 P52701 R1342W 1342 R W 0.384 Neutral MSH6 P52701 R1342Y 1342 R Y 0.342 Neutral MSH6 P52701 S1343A 1343 S A 0.01 Neutral MSH6 P52701 S1343C 1343 S C 0.032 Neutral MSH6 P52701 S1343D 1343 S D 0.044 Neutral MSH6 P52701 S1343E 1343 S E 0.114 Neutral MSH6 P52701 S1343F 1343 S F 0.276 Neutral MSH6 P52701 S1343G 1343 S G 0.036 Neutral MSH6 P52701 S1343H 1343 S H 0.238 Neutral MSH6 P52701 S1343I 1343 S I 0.124 Neutral MSH6 P52701 S1343K 1343 S K 0.164 Neutral MSH6 P52701 S1343L 1343 S L 0.028 Neutral MSH6 P52701 S1343M 1343 S M 0.28 Neutral MSH6 P52701 S1343N 1343 S N 0.004 Neutral MSH6 P52701 S1343P 1343 S P 0.056 Neutral MSH6 P52701 S1343Q 1343 S Q 0.132 Neutral MSH6 P52701 S1343R 1343 S R 0.248 Neutral MSH6 P52701 S1343T 1343 S T 0.104 Neutral MSH6 P52701 S1343V 1343 S V 0.134 Neutral MSH6 P52701 S1343W 1343 S W 0.49 Neutral MSH6 P52701 S1343Y 1343 S Y 0.448 Neutral MSH6 P52701 T1344A 1344 T A 0 Neutral MSH6 P52701 T1344C 1344 T C 0.034 Neutral MSH6 P52701 T1344D 1344 T D 0.046 Neutral MSH6 P52701 T1344E 1344 T E 0.05 Neutral MSH6 P52701 T1344F 1344 T F 0.214 Neutral MSH6 P52701 T1344G 1344 T G 0.056 Neutral MSH6 P52701 T1344H 1344 T H 0.084 Neutral MSH6 P52701 T1344I 1344 T I 0.096 Neutral MSH6 P52701 T1344K 1344 T K 0.032 Neutral MSH6 P52701 T1344L 1344 T L 0.016 Neutral MSH6 P52701 T1344M 1344 T M 0.098 Neutral MSH6 P52701 T1344N 1344 T N 0.02 Neutral MSH6 P52701 T1344P 1344 T P 0.084 Neutral MSH6 P52701 T1344Q 1344 T Q 0.016 Neutral MSH6 P52701 T1344R 1344 T R 0.174 Neutral MSH6 P52701 T1344S 1344 T S 0 Neutral MSH6 P52701 T1344V 1344 T V 0.096 Neutral MSH6 P52701 T1344W 1344 T W 0.466 Neutral MSH6 P52701 T1344Y 1344 T Y 0.424 Neutral MSH6 P52701 V1345A 1345 V A 0 Neutral MSH6 P52701 V1345C 1345 V C 0.016 Neutral MSH6 P52701 V1345D 1345 V D 0.122 Neutral MSH6 P52701 V1345E 1345 V E 0.158 Neutral MSH6 P52701 V1345F 1345 V F 0.142 Neutral MSH6 P52701 V1345G 1345 V G 0.038 Neutral MSH6 P52701 V1345H 1345 V H 0.068 Neutral MSH6 P52701 V1345I 1345 V I 0.002 Neutral MSH6 P52701 V1345K 1345 V K 0.116 Neutral MSH6 P52701 V1345L 1345 V L 0.002 Neutral MSH6 P52701 V1345M 1345 V M 0.076 Neutral MSH6 P52701 V1345N 1345 V N 0.138 Neutral MSH6 P52701 V1345P 1345 V P 0.038 Neutral MSH6 P52701 V1345Q 1345 V Q 0.216 Neutral MSH6 P52701 V1345R 1345 V R 0.21 Neutral MSH6 P52701 V1345S 1345 V S 0.012 Neutral MSH6 P52701 V1345T 1345 V T 0.058 Neutral MSH6 P52701 V1345W 1345 V W 0.344 Neutral MSH6 P52701 V1345Y 1345 V Y 0.256 Neutral MSH6 P52701 D1346A 1346 D A 0.028 Neutral MSH6 P52701 D1346C 1346 D C 0.148 Neutral MSH6 P52701 D1346E 1346 D E 0.014 Neutral MSH6 P52701 D1346F 1346 D F 0.37 Neutral MSH6 P52701 D1346G 1346 D G 0.018 Neutral MSH6 P52701 D1346H 1346 D H 0.09 Neutral MSH6 P52701 D1346I 1346 D I 0.214 Neutral MSH6 P52701 D1346K 1346 D K 0.176 Neutral MSH6 P52701 D1346L 1346 D L 0.262 Neutral MSH6 P52701 D1346M 1346 D M 0.19 Neutral MSH6 P52701 D1346N 1346 D N 0 Neutral MSH6 P52701 D1346P 1346 D P 0.288 Neutral MSH6 P52701 D1346Q 1346 D Q 0.112 Neutral MSH6 P52701 D1346R 1346 D R 0.128 Neutral MSH6 P52701 D1346S 1346 D S 0.074 Neutral MSH6 P52701 D1346T 1346 D T 0.154 Neutral MSH6 P52701 D1346V 1346 D V 0.242 Neutral MSH6 P52701 D1346W 1346 D W 0.434 Neutral MSH6 P52701 D1346Y 1346 D Y 0.404 Neutral MSH6 P52701 A1347C 1347 A C 0.182 Neutral MSH6 P52701 A1347D 1347 A D 0.266 Neutral MSH6 P52701 A1347E 1347 A E 0.306 Neutral MSH6 P52701 A1347F 1347 A F 0.468 Neutral MSH6 P52701 A1347G 1347 A G 0.006 Neutral MSH6 P52701 A1347H 1347 A H 0.304 Neutral MSH6 P52701 A1347I 1347 A I 0.406 Neutral MSH6 P52701 A1347K 1347 A K 0.254 Neutral MSH6 P52701 A1347L 1347 A L 0.354 Neutral MSH6 P52701 A1347M 1347 A M 0.29 Neutral MSH6 P52701 A1347N 1347 A N 0.296 Neutral MSH6 P52701 A1347P 1347 A P 0.272 Neutral MSH6 P52701 A1347Q 1347 A Q 0.278 Neutral MSH6 P52701 A1347R 1347 A R 0.302 Neutral MSH6 P52701 A1347S 1347 A S 0.008 Neutral MSH6 P52701 A1347T 1347 A T 0.03 Neutral MSH6 P52701 A1347V 1347 A V 0.04 Neutral MSH6 P52701 A1347W 1347 A W 0.504 Pathogenic MSH6 P52701 A1347Y 1347 A Y 0.5 Pathogenic MSH6 P52701 E1348A 1348 E A 0.066 Neutral MSH6 P52701 E1348C 1348 E C 0.068 Neutral MSH6 P52701 E1348D 1348 E D 0.048 Neutral MSH6 P52701 E1348F 1348 E F 0.272 Neutral MSH6 P52701 E1348G 1348 E G 0.084 Neutral MSH6 P52701 E1348H 1348 E H 0.162 Neutral MSH6 P52701 E1348I 1348 E I 0.322 Neutral MSH6 P52701 E1348K 1348 E K 0.068 Neutral MSH6 P52701 E1348L 1348 E L 0.138 Neutral MSH6 P52701 E1348M 1348 E M 0.164 Neutral MSH6 P52701 E1348N 1348 E N 0.002 Neutral MSH6 P52701 E1348P 1348 E P 0.3 Neutral MSH6 P52701 E1348Q 1348 E Q 0 Neutral MSH6 P52701 E1348R 1348 E R 0.03 Neutral MSH6 P52701 E1348S 1348 E S 0.014 Neutral MSH6 P52701 E1348T 1348 E T 0.006 Neutral MSH6 P52701 E1348V 1348 E V 0.25 Neutral MSH6 P52701 E1348W 1348 E W 0.43 Neutral MSH6 P52701 E1348Y 1348 E Y 0.338 Neutral MSH6 P52701 A1349C 1349 A C 0.212 Neutral MSH6 P52701 A1349D 1349 A D 0.33 Neutral MSH6 P52701 A1349E 1349 A E 0.302 Neutral MSH6 P52701 A1349F 1349 A F 0.468 Neutral MSH6 P52701 A1349G 1349 A G 0.006 Neutral MSH6 P52701 A1349H 1349 A H 0.26 Neutral MSH6 P52701 A1349I 1349 A I 0.406 Neutral MSH6 P52701 A1349K 1349 A K 0.354 Neutral MSH6 P52701 A1349L 1349 A L 0.354 Neutral MSH6 P52701 A1349M 1349 A M 0.29 Neutral MSH6 P52701 A1349N 1349 A N 0.274 Neutral MSH6 P52701 A1349P 1349 A P 0.272 Neutral MSH6 P52701 A1349Q 1349 A Q 0.252 Neutral MSH6 P52701 A1349R 1349 A R 0.326 Neutral MSH6 P52701 A1349S 1349 A S 0.024 Neutral MSH6 P52701 A1349T 1349 A T 0.08 Neutral MSH6 P52701 A1349V 1349 A V 0.074 Neutral MSH6 P52701 A1349W 1349 A W 0.364 Neutral MSH6 P52701 A1349Y 1349 A Y 0.37 Neutral MSH6 P52701 D135A 135 D A 0.146 Neutral MSH6 P52701 D135C 135 D C 0.262 Neutral MSH6 P52701 D135E 135 D E 0.02 Neutral MSH6 P52701 D135F 135 D F 0.626 Pathogenic MSH6 P52701 D135G 135 D G 0.04 Neutral MSH6 P52701 D135H 135 D H 0.16 Neutral MSH6 P52701 D135I 135 D I 0.438 Neutral MSH6 P52701 D135K 135 D K 0.308 Neutral MSH6 P52701 D135L 135 D L 0.43 Neutral MSH6 P52701 D135M 135 D M 0.338 Neutral MSH6 P52701 D135N 135 D N 0.094 Neutral MSH6 P52701 D135P 135 D P 0.45 Neutral MSH6 P52701 D135Q 135 D Q 0.18 Neutral MSH6 P52701 D135R 135 D R 0.342 Neutral MSH6 P52701 D135S 135 D S 0.218 Neutral MSH6 P52701 D135T 135 D T 0.196 Neutral MSH6 P52701 D135V 135 D V 0.43 Neutral MSH6 P52701 D135W 135 D W 0.712 Pathogenic MSH6 P52701 D135Y 135 D Y 0.684 Pathogenic MSH6 P52701 V1350A 1350 V A 0.022 Neutral MSH6 P52701 V1350C 1350 V C 0.058 Neutral MSH6 P52701 V1350D 1350 V D 0.122 Neutral MSH6 P52701 V1350E 1350 V E 0.158 Neutral MSH6 P52701 V1350F 1350 V F 0.168 Neutral MSH6 P52701 V1350G 1350 V G 0.118 Neutral MSH6 P52701 V1350H 1350 V H 0.112 Neutral MSH6 P52701 V1350I 1350 V I 0.004 Neutral MSH6 P52701 V1350K 1350 V K 0.158 Neutral MSH6 P52701 V1350L 1350 V L 0 Neutral MSH6 P52701 V1350M 1350 V M 0.076 Neutral MSH6 P52701 V1350N 1350 V N 0.038 Neutral MSH6 P52701 V1350P 1350 V P 0.19 Neutral MSH6 P52701 V1350Q 1350 V Q 0.158 Neutral MSH6 P52701 V1350R 1350 V R 0.274 Neutral MSH6 P52701 V1350S 1350 V S 0.07 Neutral MSH6 P52701 V1350T 1350 V T 0.058 Neutral MSH6 P52701 V1350W 1350 V W 0.344 Neutral MSH6 P52701 V1350Y 1350 V Y 0.256 Neutral MSH6 P52701 H1351A 1351 H A 0.076 Neutral MSH6 P52701 H1351C 1351 H C 0.042 Neutral MSH6 P52701 H1351D 1351 H D 0 Neutral MSH6 P52701 H1351E 1351 H E 0.058 Neutral MSH6 P52701 H1351F 1351 H F 0.204 Neutral MSH6 P52701 H1351G 1351 H G 0.04 Neutral MSH6 P52701 H1351I 1351 H I 0.258 Neutral MSH6 P52701 H1351K 1351 H K 0.004 Neutral MSH6 P52701 H1351L 1351 H L 0.232 Neutral MSH6 P52701 H1351M 1351 H M 0.108 Neutral MSH6 P52701 H1351N 1351 H N 0.058 Neutral MSH6 P52701 H1351P 1351 H P 0.21 Neutral MSH6 P52701 H1351Q 1351 H Q 0.014 Neutral MSH6 P52701 H1351R 1351 H R 0 Neutral MSH6 P52701 H1351S 1351 H S 0.014 Neutral MSH6 P52701 H1351T 1351 H T 0.008 Neutral MSH6 P52701 H1351V 1351 H V 0.144 Neutral MSH6 P52701 H1351W 1351 H W 0.398 Neutral MSH6 P52701 H1351Y 1351 H Y 0.306 Neutral MSH6 P52701 K1352A 1352 K A 0.096 Neutral MSH6 P52701 K1352C 1352 K C 0.028 Neutral MSH6 P52701 K1352D 1352 K D 0.066 Neutral MSH6 P52701 K1352E 1352 K E 0.004 Neutral MSH6 P52701 K1352F 1352 K F 0.212 Neutral MSH6 P52701 K1352G 1352 K G 0.13 Neutral MSH6 P52701 K1352H 1352 K H 0.048 Neutral MSH6 P52701 K1352I 1352 K I 0.222 Neutral MSH6 P52701 K1352L 1352 K L 0.214 Neutral MSH6 P52701 K1352M 1352 K M 0.106 Neutral MSH6 P52701 K1352N 1352 K N 0.046 Neutral MSH6 P52701 K1352P 1352 K P 0.236 Neutral MSH6 P52701 K1352Q 1352 K Q 0.048 Neutral MSH6 P52701 K1352R 1352 K R 0.002 Neutral MSH6 P52701 K1352S 1352 K S 0.012 Neutral MSH6 P52701 K1352T 1352 K T 0.012 Neutral MSH6 P52701 K1352V 1352 K V 0.12 Neutral MSH6 P52701 K1352W 1352 K W 0.396 Neutral MSH6 P52701 K1352Y 1352 K Y 0.326 Neutral MSH6 P52701 L1353A 1353 L A 0.022 Neutral MSH6 P52701 L1353C 1353 L C 0.094 Neutral MSH6 P52701 L1353D 1353 L D 0.172 Neutral MSH6 P52701 L1353E 1353 L E 0.034 Neutral MSH6 P52701 L1353F 1353 L F 0.248 Neutral MSH6 P52701 L1353G 1353 L G 0.192 Neutral MSH6 P52701 L1353H 1353 L H 0.084 Neutral MSH6 P52701 L1353I 1353 L I 0.004 Neutral MSH6 P52701 L1353K 1353 L K 0.124 Neutral MSH6 P52701 L1353M 1353 L M 0.134 Neutral MSH6 P52701 L1353N 1353 L N 0.16 Neutral MSH6 P52701 L1353P 1353 L P 0.234 Neutral MSH6 P52701 L1353Q 1353 L Q 0.05 Neutral MSH6 P52701 L1353R 1353 L R 0.292 Neutral MSH6 P52701 L1353S 1353 L S 0.136 Neutral MSH6 P52701 L1353T 1353 L T 0.098 Neutral MSH6 P52701 L1353V 1353 L V 0.08 Neutral MSH6 P52701 L1353W 1353 L W 0.398 Neutral MSH6 P52701 L1353Y 1353 L Y 0.35 Neutral MSH6 P52701 L1354A 1354 L A 0.088 Neutral MSH6 P52701 L1354C 1354 L C 0.094 Neutral MSH6 P52701 L1354D 1354 L D 0.158 Neutral MSH6 P52701 L1354E 1354 L E 0.144 Neutral MSH6 P52701 L1354F 1354 L F 0.242 Neutral MSH6 P52701 L1354G 1354 L G 0.184 Neutral MSH6 P52701 L1354H 1354 L H 0.084 Neutral MSH6 P52701 L1354I 1354 L I 0.002 Neutral MSH6 P52701 L1354K 1354 L K 0.042 Neutral MSH6 P52701 L1354M 1354 L M 0.012 Neutral MSH6 P52701 L1354N 1354 L N 0.148 Neutral MSH6 P52701 L1354P 1354 L P 0.216 Neutral MSH6 P52701 L1354Q 1354 L Q 0.018 Neutral 1 MSH6 P52701 L1354R 1354 L R 0.28 Neutral MSH6 P52701 L1354S 1354 L S 0.134 Neutral MSH6 P52701 L1354T 1354 L T 0.01 Neutral MSH6 P52701 L1354V 1354 L V 0 Neutral MSH6 P52701 L1354W 1354 L W 0.334 Neutral MSH6 P52701 L1354Y 1354 L Y 0.284 Neutral MSH6 P52701 T1355A 1355 T A 0.002 Neutral MSH6 P52701 T1355C 1355 T C 0.064 Neutral MSH6 P52701 T1355D 1355 T D 0.058 Neutral MSH6 P52701 T1355E 1355 T E 0.05 Neutral MSH6 P52701 T1355F 1355 T F 0.214 Neutral MSH6 P52701 T1355G 1355 T G 0.056 Neutral MSH6 P52701 T1355H 1355 T H 0.056 Neutral MSH6 P52701 T1355I 1355 T I 0.096 Neutral MSH6 P52701 T1355K 1355 T K 0.002 Neutral MSH6 P52701 T1355L 1355 T L 0.008 Neutral MSH6 P52701 T1355M 1355 T M 0.098 Neutral MSH6 P52701 T1355N 1355 T N 0.002 Neutral MSH6 P52701 T1355P 1355 T P 0.1 Neutral MSH6 P52701 T1355Q 1355 T Q 0 Neutral MSH6 P52701 T1355R 1355 T R 0.174 Neutral MSH6 P52701 T1355S 1355 T S 0.032 Neutral MSH6 P52701 T1355V 1355 T V 0.046 Neutral MSH6 P52701 T1355W 1355 T W 0.466 Neutral MSH6 P52701 T1355Y 1355 T Y 0.424 Neutral MSH6 P52701 L1356A 1356 L A 0.06 Neutral MSH6 P52701 L1356C 1356 L C 0.094 Neutral MSH6 P52701 L1356D 1356 L D 0.092 Neutral MSH6 P52701 L1356E 1356 L E 0.106 Neutral MSH6 P52701 L1356F 1356 L F 0.242 Neutral MSH6 P52701 L1356G 1356 L G 0.186 Neutral MSH6 P52701 L1356H 1356 L H 0.04 Neutral MSH6 P52701 L1356I 1356 L I 0.024 Neutral MSH6 P52701 L1356K 1356 L K 0.178 Neutral MSH6 P52701 L1356M 1356 L M 0.01 Neutral MSH6 P52701 L1356N 1356 L N 0.028 Neutral MSH6 P52701 L1356P 1356 L P 0.216 Neutral MSH6 P52701 L1356Q 1356 L Q 0.064 Neutral MSH6 P52701 L1356R 1356 L R 0.236 Neutral MSH6 P52701 L1356S 1356 L S 0.01 Neutral MSH6 P52701 L1356T 1356 L T 0.18 Neutral MSH6 P52701 L1356V 1356 L V 0.08 Neutral MSH6 P52701 L1356W 1356 L W 0.334 Neutral MSH6 P52701 L1356Y 1356 L Y 0.284 Neutral MSH6 P52701 I1357A 1357 I A 0.06 Neutral MSH6 P52701 I1357C 1357 I C 0.09 Neutral MSH6 P52701 I1357D 1357 I D 0.14 Neutral MSH6 P52701 I1357E 1357 I E 0.076 Neutral MSH6 P52701 I1357F 1357 I F 0.218 Neutral MSH6 P52701 I1357G 1357 I G 0.206 Neutral MSH6 P52701 I1357H 1357 I H 0.08 Neutral MSH6 P52701 I1357K 1357 I K 0.068 Neutral MSH6 P52701 I1357L 1357 I L 0 Neutral MSH6 P52701 I1357M 1357 I M 0.166 Neutral MSH6 P52701 I1357N 1357 I N 0.176 Neutral MSH6 P52701 I1357P 1357 I P 0.174 Neutral MSH6 P52701 I1357Q 1357 I Q 0.174 Neutral MSH6 P52701 I1357R 1357 I R 0.26 Neutral MSH6 P52701 I1357S 1357 I S 0.16 Neutral MSH6 P52701 I1357T 1357 I T 0.192 Neutral MSH6 P52701 I1357V 1357 I V 0 Neutral MSH6 P52701 I1357W 1357 I W 0.344 Neutral MSH6 P52701 I1357Y 1357 I Y 0.298 Neutral MSH6 P52701 K1358A 1358 K A 0.054 Neutral MSH6 P52701 K1358C 1358 K C 0.028 Neutral MSH6 P52701 K1358D 1358 K D 0.05 Neutral MSH6 P52701 K1358E 1358 K E 0.004 Neutral MSH6 P52701 K1358F 1358 K F 0.212 Neutral MSH6 P52701 K1358G 1358 K G 0.116 Neutral MSH6 P52701 K1358H 1358 K H 0.002 Neutral MSH6 P52701 K1358I 1358 K I 0.124 Neutral MSH6 P52701 K1358L 1358 K L 0.036 Neutral MSH6 P52701 K1358M 1358 K M 0.078 Neutral MSH6 P52701 K1358N 1358 K N 0.006 Neutral MSH6 P52701 K1358P 1358 K P 0.236 Neutral MSH6 P52701 K1358Q 1358 K Q 0.006 Neutral MSH6 P52701 K1358R 1358 K R 0.012 Neutral MSH6 P52701 K1358S 1358 K S 0.09 Neutral MSH6 P52701 K1358T 1358 K T 0.09 Neutral MSH6 P52701 K1358V 1358 K V 0.18 Neutral MSH6 P52701 K1358W 1358 K W 0.396 Neutral MSH6 P52701 K1358Y 1358 K Y 0.326 Neutral MSH6 P52701 E1359A 1359 E A 0.212 Neutral MSH6 P52701 E1359C 1359 E C 0.068 Neutral MSH6 P52701 E1359D 1359 E D 0 Neutral MSH6 P52701 E1359F 1359 E F 0.272 Neutral MSH6 P52701 E1359G 1359 E G 0.084 Neutral MSH6 P52701 E1359H 1359 E H 0.162 Neutral MSH6 P52701 E1359I 1359 E I 0.254 Neutral MSH6 P52701 E1359K 1359 E K 0.002 Neutral MSH6 P52701 E1359L 1359 E L 0.286 Neutral MSH6 P52701 E1359M 1359 E M 0.164 Neutral MSH6 P52701 E1359N 1359 E N 0.002 Neutral MSH6 P52701 E1359P 1359 E P 0.3 Neutral MSH6 P52701 E1359Q 1359 E Q 0.018 Neutral MSH6 P52701 E1359R 1359 E R 0.036 Neutral MSH6 P52701 E1359S 1359 E S 0.168 Neutral MSH6 P52701 E1359T 1359 E T 0.02 Neutral MSH6 P52701 E1359V 1359 E V 0.232 Neutral MSH6 P52701 E1359W 1359 E W 0.43 Neutral MSH6 P52701 E1359Y 1359 E Y 0.338 Neutral MSH6 P52701 D136A 136 D A 0.082 Neutral MSH6 P52701 D136C 136 D C 0.156 Neutral MSH6 P52701 D136E 136 D E 0.014 Neutral MSH6 P52701 D136F 136 D F 0.44 Neutral MSH6 P52701 D136G 136 D G 0.142 Neutral MSH6 P52701 D136H 136 D H 0.098 Neutral MSH6 P52701 D136I 136 D I 0.288 Neutral MSH6 P52701 D136K 136 D K 0.214 Neutral MSH6 P52701 D136L 136 D L 0.284 Neutral MSH6 P52701 D136M 136 D M 0.212 Neutral MSH6 P52701 D136N 136 D N 0 Neutral MSH6 P52701 D136P 136 D P 0.306 Neutral MSH6 P52701 D136Q 136 D Q 0.116 Neutral MSH6 P52701 D136R 136 D R 0.214 Neutral MSH6 P52701 D136S 136 D S 0.198 Neutral MSH6 P52701 D136T 136 D T 0.104 Neutral MSH6 P52701 D136V 136 D V 0.264 Neutral MSH6 P52701 D136W 136 D W 0.514 Pathogenic MSH6 P52701 D136Y 136 D Y 0.48 Neutral MSH6 P52701 L1360A 1360 L A 0.088 Neutral MSH6 P52701 L1360C 1360 L C 0.094 Neutral MSH6 P52701 L1360D 1360 L D 0.056 Neutral MSH6 P52701 L1360E 1360 L E 0.148 Neutral MSH6 P52701 L1360F 1360 L F 0.214 Neutral MSH6 P52701 L1360G 1360 L G 0.188 Neutral MSH6 P52701 L1360H 1360 L H 0.084 Neutral MSH6 P52701 L1360I 1360 L I 0.024 Neutral MSH6 P52701 L1360K 1360 L K 0.086 Neutral MSH6 P52701 L1360M 1360 L M 0.18 Neutral MSH6 P52701 L1360N 1360 L N 0.152 Neutral MSH6 P52701 L1360P 1360 L P 0.226 Neutral MSH6 P52701 L1360Q 1360 L Q 0.048 Neutral MSH6 P52701 L1360R 1360 L R 0.294 Neutral MSH6 P52701 L1360S 1360 L S 0.136 Neutral MSH6 P52701 L1360T 1360 L T 0.114 Neutral MSH6 P52701 L1360V 1360 L V 0.016 Neutral MSH6 P52701 L1360W 1360 L W 0.344 Neutral MSH6 P52701 L1360Y 1360 L Y 0.298 Neutral MSH6 P52701 S137A 137 S A 0.086 Neutral MSH6 P52701 S137C 137 S C 0.032 Neutral MSH6 P52701 S137D 137 S D 0.026 Neutral MSH6 P52701 S137E 137 S E 0.152 Neutral MSH6 P52701 S137F 137 S F 0.28 Neutral MSH6 P52701 S137G 137 S G 0.064 Neutral MSH6 P52701 S137H 137 S H 0.242 Neutral MSH6 P52701 S137I 137 S I 0.026 Neutral MSH6 P52701 S137K 137 S K 0.168 Neutral MSH6 P52701 S137L 137 S L 0.064 Neutral MSH6 P52701 S137M 137 S M 0.35 Neutral MSH6 P52701 S137N 137 S N 0 Neutral MSH6 P52701 S137P 137 S P 0.056 Neutral MSH6 P52701 S137Q 137 S Q 0.138 Neutral MSH6 P52701 S137R 137 S R 0.252 Neutral MSH6 P52701 S137T 137 S T 0.178 Neutral MSH6 P52701 S137V 137 S V 0.298 Neutral MSH6 P52701 S137W 137 S W 0.502 Pathogenic MSH6 P52701 S137Y 137 S Y 0.458 Neutral MSH6 P52701 P138A 138 P A 0.244 Neutral MSH6 P52701 P138C 138 P C 0.234 Neutral MSH6 P52701 P138D 138 P D 0.13 Neutral MSH6 P52701 P138E 138 P E 0.362 Neutral MSH6 P52701 P138F 138 P F 0.516 Pathogenic MSH6 P52701 P138G 138 P G 0.134 Neutral MSH6 P52701 P138H 138 P H 0.478 Neutral MSH6 P52701 P138I 138 P I 0.21 Neutral MSH6 P52701 P138K 138 P K 0.298 Neutral MSH6 P52701 P138L 138 P L 0.17 Neutral MSH6 P52701 P138M 138 P M 0.38 Neutral MSH6 P52701 P138N 138 P N 0.102 Neutral MSH6 P52701 P138Q 138 P Q 0.366 Neutral MSH6 P52701 P138R 138 P R 0.532 Pathogenic MSH6 P52701 P138S 138 P S 0.164 Neutral MSH6 P52701 P138T 138 P T 0.254 Neutral MSH6 P52701 P138V 138 P V 0.212 Neutral MSH6 P52701 P138W 138 P W 0.61 Pathogenic MSH6 P52701 P138Y 138 P Y 0.54 Pathogenic MSH6 P52701 T139A 139 T A 0.072 Neutral MSH6 P52701 T139C 139 T C 0.046 Neutral MSH6 P52701 T139D 139 T D 0.072 Neutral MSH6 P52701 T139E 139 T E 0.106 Neutral MSH6 P52701 T139F 139 T F 0.3 Neutral MSH6 P52701 T139G 139 T G 0.068 Neutral MSH6 P52701 T139H 139 T H 0.142 Neutral MSH6 P52701 T139I 139 T I 0.1 Neutral MSH6 P52701 T139K 139 T K 0.076 Neutral MSH6 P52701 T139L 139 T L 0.108 Neutral MSH6 P52701 T139M 139 T M 0.124 Neutral MSH6 P52701 T139N 139 T N 0.03 Neutral MSH6 P52701 T139P 139 T P 0.148 Neutral MSH6 P52701 T139Q 139 T Q 0.068 Neutral MSH6 P52701 T139R 139 T R 0.336 Neutral MSH6 P52701 T139S 139 T S 0 Neutral MSH6 P52701 T139V 139 T V 0.106 Neutral MSH6 P52701 T139W 139 T W 0.574 Pathogenic MSH6 P52701 T139Y 139 T Y 0.534 Pathogenic MSH6 P52701 S14A 14 S A 0.086 Neutral MSH6 P52701 S14C 14 S C 0.032 Neutral MSH6 P52701 S14D 14 S D 0.044 Neutral MSH6 P52701 S14E 14 S E 0.152 Neutral MSH6 P52701 S14F 14 S F 0.25 Neutral MSH6 P52701 S14G 14 S G 0.064 Neutral MSH6 P52701 S14H 14 S H 0.242 Neutral MSH6 P52701 S14I 14 S I 0.026 Neutral MSH6 P52701 S14K 14 S K 0.168 Neutral MSH6 P52701 S14L 14 S L 0.07 Neutral MSH6 P52701 S14M 14 S M 0.35 Neutral MSH6 P52701 S14N 14 S N 0.034 Neutral MSH6 P52701 S14P 14 S P 0.116 Neutral MSH6 P52701 S14Q 14 S Q 0.162 Neutral MSH6 P52701 S14R 14 S R 0.252 Neutral MSH6 P52701 S14T 14 S T 0.112 Neutral MSH6 P52701 S14V 14 S V 0.256 Neutral MSH6 P52701 S14W 14 S W 0.502 Pathogenic MSH6 P52701 S14Y 14 S Y 0.458 Neutral MSH6 P52701 R140A 140 R A 0.14 Neutral MSH6 P52701 R140C 140 R C 0.226 Neutral MSH6 P52701 R140D 140 R D 0.246 Neutral MSH6 P52701 R140E 140 R E 0.188 Neutral MSH6 P52701 R140F 140 R F 0.446 Neutral MSH6 P52701 R140G 140 R G 0.09 Neutral MSH6 P52701 R140H 140 R H 0.208 Neutral MSH6 P52701 R140I 140 R I 0.472 Neutral MSH6 P52701 R140K 140 R K 0.266 Neutral MSH6 P52701 R140L 140 R L 0.382 Neutral MSH6 P52701 R140M 140 R M 0.242 Neutral MSH6 P52701 R140N 140 R N 0.24 Neutral MSH6 P52701 R140P 140 R P 0.41 Neutral MSH6 P52701 R140Q 140 R Q 0.22 Neutral MSH6 P52701 R140S 140 R S 0.192 Neutral MSH6 P52701 R140T 140 R T 0.198 Neutral MSH6 P52701 R140V 140 R V 0.376 Neutral MSH6 P52701 R140W 140 R W 0.612 Pathogenic MSH6 P52701 R140Y 140 R Y 0.444 Neutral MSH6 P52701 G141A 141 G A 0.012 Neutral MSH6 P52701 G141C 141 G C 0.356 Neutral MSH6 P52701 G141D 141 G D 0.322 Neutral MSH6 P52701 G141E 141 G E 0.56 Pathogenic MSH6 P52701 G141F 141 G F 0.734 Pathogenic MSH6 P52701 G141H 141 G H 0.696 Pathogenic MSH6 P52701 G141I 141 G I 0.674 Pathogenic MSH6 P52701 G141K 141 G K 0.678 Pathogenic MSH6 P52701 G141L 141 G L 0.674 Pathogenic MSH6 P52701 G141M 141 G M 0.686 Pathogenic MSH6 P52701 G141N 141 G N 0.422 Neutral MSH6 P52701 G141P 141 G P 0.634 Pathogenic MSH6 P52701 G141Q 141 G Q 0.454 Neutral MSH6 P52701 G141R 141 G R 0.738 Pathogenic MSH6 P52701 G141S 141 G S 0.036 Neutral MSH6 P52701 G141T 141 G T 0.468 Neutral MSH6 P52701 G141V 141 G V 0.652 Pathogenic MSH6 P52701 G141W 141 G W 0.75 Pathogenic MSH6 P52701 G141Y 141 G Y 0.734 Pathogenic MSH6 P52701 W142A 142 W A 0.128 Neutral MSH6 P52701 W142C 142 W C 0.128 Neutral MSH6 P52701 W142D 142 W D 0.19 Neutral MSH6 P52701 W142E 142 W E 0.24 Neutral MSH6 P52701 W142F 142 W F 0.092 Neutral MSH6 P52701 W142G 142 W G 0.138 Neutral MSH6 P52701 W142H 142 W H 0.128 Neutral MSH6 P52701 W142I 142 W I 0.13 Neutral MSH6 P52701 W142K 142 W K 0.234 Neutral MSH6 P52701 W142L 142 W L 0.094 Neutral MSH6 P52701 W142M 142 W M 0.122 Neutral MSH6 P52701 W142N 142 W N 0.138 Neutral MSH6 P52701 W142P 142 W P 0.146 Neutral MSH6 P52701 W142Q 142 W Q 0.138 Neutral MSH6 P52701 W142R 142 W R 0.228 Neutral MSH6 P52701 W142S 142 W S 0.182 Neutral MSH6 P52701 W142T 142 W T 0.128 Neutral MSH6 P52701 W142V 142 W V 0.15 Neutral MSH6 P52701 W142Y 142 W Y 0.194 Neutral MSH6 P52701 V143A 143 V A 0.052 Neutral MSH6 P52701 V143C 143 V C 0.11 Neutral MSH6 P52701 V143D 143 V D 0.204 Neutral MSH6 P52701 V143E 143 V E 0.334 Neutral MSH6 P52701 V143F 143 V F 0.324 Neutral MSH6 P52701 V143G 143 V G 0.286 Neutral MSH6 P52701 V143H 143 V H 0.23 Neutral MSH6 P52701 V143I 143 V I 0.008 Neutral MSH6 P52701 V143K 143 V K 0.302 Neutral MSH6 P52701 V143L 143 V L 0.13 Neutral MSH6 P52701 V143M 143 V M 0.172 Neutral MSH6 P52701 V143N 143 V N 0.222 Neutral MSH6 P52701 V143P 143 V P 0.35 Neutral MSH6 P52701 V143Q 143 V Q 0.358 Neutral MSH6 P52701 V143R 143 V R 0.494 Neutral MSH6 P52701 V143S 143 V S 0.148 Neutral MSH6 P52701 V143T 143 V T 0.076 Neutral MSH6 P52701 V143W 143 V W 0.554 Pathogenic MSH6 P52701 V143Y 143 V Y 0.472 Neutral MSH6 P52701 S144A 144 S A 0.052 Neutral MSH6 P52701 S144C 144 S C 0.032 Neutral MSH6 P52701 S144D 144 S D 0.048 Neutral MSH6 P52701 S144E 144 S E 0.17 Neutral MSH6 P52701 S144F 144 S F 0.302 Neutral MSH6 P52701 S144G 144 S G 0 Neutral MSH6 P52701 S144H 144 S H 0.216 Neutral MSH6 P52701 S144I 144 S I 0.036 Neutral 1 MSH6 P52701 S144K 144 S K 0.174 Neutral MSH6 P52701 S144L 144 S L 0.086 Neutral MSH6 P52701 S144M 144 S M 0.384 Neutral MSH6 P52701 S144N 144 S N 0.004 Neutral MSH6 P52701 S144P 144 S P 0.122 Neutral MSH6 P52701 S144Q 144 S Q 0.18 Neutral MSH6 P52701 S144R 144 S R 0.2 Neutral MSH6 P52701 S144T 144 S T 0.112 Neutral MSH6 P52701 S144V 144 S V 0.26 Neutral MSH6 P52701 S144W 144 S W 0.532 Pathogenic MSH6 P52701 S144Y 144 S Y 0.488 Neutral MSH6 P52701 K145A 145 K A 0.028 Neutral MSH6 P52701 K145C 145 K C 0.028 Neutral MSH6 P52701 K145D 145 K D 0.05 Neutral MSH6 P52701 K145E 145 K E 0.052 Neutral MSH6 P52701 K145F 145 K F 0.212 Neutral MSH6 P52701 K145G 145 K G 0.13 Neutral MSH6 P52701 K145H 145 K H 0.018 Neutral MSH6 P52701 K145I 145 K I 0.04 Neutral MSH6 P52701 K145L 145 K L 0.148 Neutral MSH6 P52701 K145M 145 K M 0.078 Neutral MSH6 P52701 K145N 145 K N 0.082 Neutral MSH6 P52701 K145P 145 K P 0.236 Neutral MSH6 P52701 K145Q 145 K Q 0.09 Neutral MSH6 P52701 K145R 145 K R 0.004 Neutral MSH6 P52701 K145S 145 K S 0.024 Neutral MSH6 P52701 K145T 145 K T 0.014 Neutral MSH6 P52701 K145V 145 K V 0.022 Neutral MSH6 P52701 K145W 145 K W 0.396 Neutral MSH6 P52701 K145Y 145 K Y 0.326 Neutral MSH6 P52701 R146A 146 R A 0.088 Neutral MSH6 P52701 R146C 146 R C 0.154 Neutral MSH6 P52701 R146D 146 R D 0.182 Neutral MSH6 P52701 R146E 146 R E 0.13 Neutral MSH6 P52701 R146F 146 R F 0.306 Neutral MSH6 P52701 R146G 146 R G 0.072 Neutral MSH6 P52701 R146H 146 R H 0.144 Neutral MSH6 P52701 R146I 146 R I 0.326 Neutral MSH6 P52701 R146K 146 R K 0.004 Neutral MSH6 P52701 R146L 146 R L 0.29 Neutral MSH6 P52701 R146M 146 R M 0.164 Neutral MSH6 P52701 R146N 146 R N 0.2 Neutral MSH6 P52701 R146P 146 R P 0.282 Neutral MSH6 P52701 R146Q 146 R Q 0.162 Neutral MSH6 P52701 R146S 146 R S 0.166 Neutral MSH6 P52701 R146T 146 R T 0.144 Neutral MSH6 P52701 R146V 146 R V 0.258 Neutral MSH6 P52701 R146W 146 R W 0.444 Neutral MSH6 P52701 R146Y 146 R Y 0.198 Neutral MSH6 P52701 L147A 147 L A 0.088 Neutral MSH6 P52701 L147C 147 L C 0.094 Neutral MSH6 P52701 L147D 147 L D 0.092 Neutral MSH6 P52701 L147E 147 L E 0.144 Neutral MSH6 P52701 L147F 147 L F 0.142 Neutral MSH6 P52701 L147G 147 L G 0.186 Neutral MSH6 P52701 L147H 147 L H 0.084 Neutral MSH6 P52701 L147I 147 L I 0.072 Neutral MSH6 P52701 L147K 147 L K 0.084 Neutral MSH6 P52701 L147M 147 L M 0.012 Neutral MSH6 P52701 L147N 147 L N 0.028 Neutral MSH6 P52701 L147P 147 L P 0.216 Neutral MSH6 P52701 L147Q 147 L Q 0.018 Neutral MSH6 P52701 L147R 147 L R 0.218 Neutral MSH6 P52701 L147S 147 L S 0.204 Neutral MSH6 P52701 L147T 147 L T 0.112 Neutral MSH6 P52701 L147V 147 L V 0.114 Neutral MSH6 P52701 L147W 147 L W 0.334 Neutral MSH6 P52701 L147Y 147 L Y 0.286 Neutral MSH6 P52701 L148A 148 L A 0.008 Neutral MSH6 P52701 L148C 148 L C 0.056 Neutral MSH6 P52701 L148D 148 L D 0.158 Neutral MSH6 P52701 L148E 148 L E 0.144 Neutral MSH6 P52701 L148F 148 L F 0.204 Neutral MSH6 P52701 L148G 148 L G 0.186 Neutral MSH6 P52701 L148H 148 L H 0.084 Neutral MSH6 P52701 L148I 148 L I 0.002 Neutral MSH6 P52701 L148K 148 L K 0.116 Neutral MSH6 P52701 L148M 148 L M 0.08 Neutral MSH6 P52701 L148N 148 L N 0.148 Neutral MSH6 P52701 L148P 148 L P 0.224 Neutral MSH6 P52701 L148Q 148 L Q 0.064 Neutral MSH6 P52701 L148R 148 L R 0.28 Neutral MSH6 P52701 L148S 148 L S 0.134 Neutral MSH6 P52701 L148T 148 L T 0.18 Neutral MSH6 P52701 L148V 148 L V 0 Neutral MSH6 P52701 L148W 148 L W 0.334 Neutral MSH6 P52701 L148Y 148 L Y 0.284 Neutral MSH6 P52701 K149A 149 K A 0.084 Neutral MSH6 P52701 K149C 149 K C 0.056 Neutral MSH6 P52701 K149D 149 K D 0.096 Neutral MSH6 P52701 K149E 149 K E 0.036 Neutral MSH6 P52701 K149F 149 K F 0.334 Neutral MSH6 P52701 K149G 149 K G 0.172 Neutral MSH6 P52701 K149H 149 K H 0.082 Neutral MSH6 P52701 K149I 149 K I 0.322 Neutral MSH6 P52701 K149L 149 K L 0.348 Neutral MSH6 P52701 K149M 149 K M 0.176 Neutral MSH6 P52701 K149N 149 K N 0.118 Neutral MSH6 P52701 K149P 149 K P 0.356 Neutral MSH6 P52701 K149Q 149 K Q 0.124 Neutral MSH6 P52701 K149R 149 K R 0.004 Neutral MSH6 P52701 K149S 149 K S 0.226 Neutral MSH6 P52701 K149T 149 K T 0.132 Neutral MSH6 P52701 K149V 149 K V 0.272 Neutral MSH6 P52701 K149W 149 K W 0.636 Pathogenic MSH6 P52701 K149Y 149 K Y 0.542 Pathogenic MSH6 P52701 P15A 15 P A 0.178 Neutral MSH6 P52701 P15C 15 P C 0.152 Neutral MSH6 P52701 P15D 15 P D 0.078 Neutral MSH6 P52701 P15E 15 P E 0.228 Neutral MSH6 P52701 P15F 15 P F 0.256 Neutral MSH6 P52701 P15G 15 P G 0.092 Neutral MSH6 P52701 P15H 15 P H 0.28 Neutral MSH6 P52701 P15I 15 P I 0.112 Neutral MSH6 P52701 P15K 15 P K 0.22 Neutral MSH6 P52701 P15L 15 P L 0.116 Neutral MSH6 P52701 P15M 15 P M 0.234 Neutral MSH6 P52701 P15N 15 P N 0.068 Neutral MSH6 P52701 P15Q 15 P Q 0.226 Neutral MSH6 P52701 P15R 15 P R 0.32 Neutral MSH6 P52701 P15S 15 P S 0.114 Neutral MSH6 P52701 P15T 15 P T 0.126 Neutral MSH6 P52701 P15V 15 P V 0.144 Neutral MSH6 P52701 P15W 15 P W 0.408 Neutral MSH6 P52701 P15Y 15 P Y 0.338 Neutral MSH6 P52701 P150A 150 P A 0.054 Neutral MSH6 P52701 P150C 150 P C 0.158 Neutral MSH6 P52701 P150D 150 P D 0.08 Neutral MSH6 P52701 P150E 150 P E 0.064 Neutral MSH6 P52701 P150F 150 P F 0.326 Neutral MSH6 P52701 P150G 150 P G 0.07 Neutral MSH6 P52701 P150H 150 P H 0.31 Neutral MSH6 P52701 P150I 150 P I 0.12 Neutral MSH6 P52701 P150K 150 P K 0.062 Neutral MSH6 P52701 P150L 150 P L 0.102 Neutral MSH6 P52701 P150M 150 P M 0.254 Neutral MSH6 P52701 P150N 150 P N 0.068 Neutral MSH6 P52701 P150Q 150 P Q 0.182 Neutral MSH6 P52701 P150R 150 P R 0.356 Neutral MSH6 P52701 P150S 150 P S 0.114 Neutral MSH6 P52701 P150T 150 P T 0.126 Neutral MSH6 P52701 P150V 150 P V 0.15 Neutral MSH6 P52701 P150W 150 P W 0.438 Neutral MSH6 P52701 P150Y 150 P Y 0.364 Neutral MSH6 P52701 Y151A 151 Y A 0.106 Neutral MSH6 P52701 Y151C 151 Y C 0.15 Neutral MSH6 P52701 Y151D 151 Y D 0.272 Neutral MSH6 P52701 Y151E 151 Y E 0.266 Neutral MSH6 P52701 Y151F 151 Y F 0.01 Neutral MSH6 P52701 Y151G 151 Y G 0.148 Neutral MSH6 P52701 Y151H 151 Y H 0.088 Neutral MSH6 P52701 Y151I 151 Y I 0.152 Neutral MSH6 P52701 Y151K 151 Y K 0.256 Neutral MSH6 P52701 Y151L 151 Y L 0.082 Neutral MSH6 P52701 Y151M 151 Y M 0.134 Neutral MSH6 P52701 Y151N 151 Y N 0.178 Neutral MSH6 P52701 Y151P 151 Y P 0.122 Neutral MSH6 P52701 Y151Q 151 Y Q 0.168 Neutral MSH6 P52701 Y151R 151 Y R 0.244 Neutral MSH6 P52701 Y151S 151 Y S 0.15 Neutral MSH6 P52701 Y151T 151 Y T 0.152 Neutral MSH6 P52701 Y151V 151 Y V 0.214 Neutral MSH6 P52701 Y151W 151 Y W 0.112 Neutral MSH6 P52701 T152A 152 T A 0.08 Neutral MSH6 P52701 T152C 152 T C 0.064 Neutral MSH6 P52701 T152D 152 T D 0.058 Neutral MSH6 P52701 T152E 152 T E 0.04 Neutral MSH6 P52701 T152F 152 T F 0.214 Neutral MSH6 P52701 T152G 152 T G 0.058 Neutral MSH6 P52701 T152H 152 T H 0.064 Neutral MSH6 P52701 T152I 152 T I 0.066 Neutral MSH6 P52701 T152K 152 T K 0.002 Neutral MSH6 P52701 T152L 152 T L 0.074 Neutral MSH6 P52701 T152M 152 T M 0.098 Neutral MSH6 P52701 T152N 152 T N 0.002 Neutral MSH6 P52701 T152P 152 T P 0.1 Neutral MSH6 P52701 T152Q 152 T Q 0 Neutral MSH6 P52701 T152R 152 T R 0.156 Neutral MSH6 P52701 T152S 152 T S 0 Neutral MSH6 P52701 T152V 152 T V 0.206 Neutral MSH6 P52701 T152W 152 T W 0.466 Neutral MSH6 P52701 T152Y 152 T Y 0.424 Neutral MSH6 P52701 G153A 153 G A 0.16 Neutral MSH6 P52701 G153C 153 G C 0.364 Neutral MSH6 P52701 G153D 153 G D 0.43 Neutral MSH6 P52701 G153E 153 G E 0.432 Neutral MSH6 P52701 G153F 153 G F 0.762 Pathogenic MSH6 P52701 G153H 153 G H 0.706 Pathogenic MSH6 P52701 G153I 153 G I 0.676 Pathogenic MSH6 P52701 G153K 153 G K 0.686 Pathogenic MSH6 P52701 G153L 153 G L 0.684 Pathogenic MSH6 P52701 G153M 153 G M 0.694 Pathogenic MSH6 P52701 G153N 153 G N 0.424 Neutral MSH6 P52701 G153P 153 G P 0.634 Pathogenic MSH6 P52701 G153Q 153 G Q 0.454 Neutral MSH6 P52701 G153R 153 G R 0.756 Pathogenic MSH6 P52701 G153S 153 G S 0.284 Neutral MSH6 P52701 G153T 153 G T 0.466 Neutral MSH6 P52701 G153V 153 G V 0.656 Pathogenic MSH6 P52701 G153W 153 G W 0.76 Pathogenic MSH6 P52701 G153Y 153 G Y 0.744 Pathogenic MSH6 P52701 S154A 154 S A 0.03 Neutral MSH6 P52701 S154C 154 S C 0.074 Neutral MSH6 P52701 S154D 154 S D 0.116 Neutral MSH6 P52701 S154E 154 S E 0.328 Neutral MSH6 P52701 S154F 154 S F 0.518 Pathogenic MSH6 P52701 S154G 154 S G 0.118 Neutral MSH6 P52701 S154H 154 S H 0.444 Neutral MSH6 P52701 S154I 154 S I 0.168 Neutral MSH6 P52701 S154K 154 S K 0.326 Neutral MSH6 P52701 S154L 154 S L 0.172 Neutral MSH6 P52701 S154M 154 S M 0.626 Pathogenic MSH6 P52701 S154N 154 S N 0.098 Neutral MSH6 P52701 S154P 154 S P 0.212 Neutral MSH6 P52701 S154Q 154 S Q 0.318 Neutral MSH6 P52701 S154R 154 S R 0.444 Neutral MSH6 P52701 S154T 154 S T 0.26 Neutral MSH6 P52701 S154V 154 S V 0.404 Neutral MSH6 P52701 S154W 154 S W 0.74 Pathogenic MSH6 P52701 S154Y 154 S Y 0.696 Pathogenic MSH6 P52701 K155A 155 K A 0.056 Neutral MSH6 P52701 K155C 155 K C 0.028 Neutral MSH6 P52701 K155D 155 K D 0.002 Neutral MSH6 P52701 K155E 155 K E 0.072 Neutral MSH6 P52701 K155F 155 K F 0.212 Neutral MSH6 P52701 K155G 155 K G 0.13 Neutral MSH6 P52701 K155H 155 K H 0.048 Neutral MSH6 P52701 K155I 155 K I 0.222 Neutral MSH6 P52701 K155L 155 K L 0.214 Neutral MSH6 P52701 K155M 155 K M 0.106 Neutral MSH6 P52701 K155N 155 K N 0.014 Neutral MSH6 P52701 K155P 155 K P 0.236 Neutral MSH6 P52701 K155Q 155 K Q 0.09 Neutral MSH6 P52701 K155R 155 K R 0.016 Neutral MSH6 P52701 K155S 155 K S 0.014 Neutral MSH6 P52701 K155T 155 K T 0.018 Neutral MSH6 P52701 K155V 155 K V 0.18 Neutral MSH6 P52701 K155W 155 K W 0.396 Neutral MSH6 P52701 K155Y 155 K Y 0.326 Neutral MSH6 P52701 S156A 156 S A 0.012 Neutral MSH6 P52701 S156C 156 S C 0.002 Neutral MSH6 P52701 S156D 156 S D 0.002 Neutral MSH6 P52701 S156E 156 S E 0.148 Neutral MSH6 P52701 S156F 156 S F 0.276 Neutral MSH6 P52701 S156G 156 S G 0.066 Neutral MSH6 P52701 S156H 156 S H 0.188 Neutral MSH6 P52701 S156I 156 S I 0.026 Neutral MSH6 P52701 S156K 156 S K 0.14 Neutral MSH6 P52701 S156L 156 S L 0.028 Neutral MSH6 P52701 S156M 156 S M 0.332 Neutral MSH6 P52701 S156N 156 S N 0.034 Neutral MSH6 P52701 S156P 156 S P 0.066 Neutral MSH6 P52701 S156Q 156 S Q 0.158 Neutral MSH6 P52701 S156R 156 S R 0.248 Neutral MSH6 P52701 S156T 156 S T 0.11 Neutral MSH6 P52701 S156V 156 S V 0.134 Neutral MSH6 P52701 S156W 156 S W 0.49 Neutral MSH6 P52701 S156Y 156 S Y 0.448 Neutral MSH6 P52701 K157A 157 K A 0.028 Neutral MSH6 P52701 K157C 157 K C 0.028 Neutral MSH6 P52701 K157D 157 K D 0.05 Neutral MSH6 P52701 K157E 157 K E 0.03 Neutral MSH6 P52701 K157F 157 K F 0.212 Neutral MSH6 P52701 K157G 157 K G 0.116 Neutral MSH6 P52701 K157H 157 K H 0.048 Neutral MSH6 P52701 K157I 157 K I 0.222 Neutral MSH6 P52701 K157L 157 K L 0.214 Neutral MSH6 P52701 K157M 157 K M 0.038 Neutral MSH6 P52701 K157N 157 K N 0.082 Neutral MSH6 P52701 K157P 157 K P 0.236 Neutral MSH6 P52701 K157Q 157 K Q 0.09 Neutral MSH6 P52701 K157R 157 K R 0.002 Neutral MSH6 P52701 K157S 157 K S 0.012 Neutral MSH6 P52701 K157T 157 K T 0.09 Neutral MSH6 P52701 K157V 157 K V 0.184 Neutral MSH6 P52701 K157W 157 K W 0.396 Neutral MSH6 P52701 K157Y 157 K Y 0.326 Neutral MSH6 P52701 E158A 158 E A 0.122 Neutral MSH6 P52701 E158C 158 E C 0.068 Neutral MSH6 P52701 E158D 158 E D 0 Neutral MSH6 P52701 E158F 158 E F 0.106 Neutral MSH6 P52701 E158G 158 E G 0.024 Neutral MSH6 P52701 E158H 158 E H 0.164 Neutral MSH6 P52701 E158I 158 E I 0.31 Neutral MSH6 P52701 E158K 158 E K 0.168 Neutral MSH6 P52701 E158L 158 E L 0.308 Neutral MSH6 P52701 E158M 158 E M 0.176 Neutral MSH6 P52701 E158N 158 E N 0.056 Neutral MSH6 P52701 E158P 158 E P 0.302 Neutral MSH6 P52701 E158Q 158 E Q 0.056 Neutral MSH6 P52701 E158R 158 E R 0.048 Neutral MSH6 P52701 E158S 158 E S 0.17 Neutral MSH6 P52701 E158T 158 E T 0.144 Neutral MSH6 P52701 E158V 158 E V 0.272 Neutral MSH6 P52701 E158W 158 E W 0.494 Neutral MSH6 P52701 E158Y 158 E Y 0.388 Neutral MSH6 P52701 A159C 159 A C 0.096 Neutral MSH6 P52701 A159D 159 A D 0.266 Neutral MSH6 P52701 A159E 159 A E 0.306 Neutral MSH6 P52701 A159F 159 A F 0.34 Neutral MSH6 P52701 A159G 159 A G 0.12 Neutral MSH6 P52701 A159H 159 A H 0.304 Neutral MSH6 P52701 A159I 159 A I 0.406 Neutral MSH6 P52701 A159K 159 A K 0.354 Neutral MSH6 P52701 A159L 159 A L 0.414 Neutral MSH6 P52701 A159M 159 A M 0.29 Neutral MSH6 P52701 A159N 159 A N 0.274 Neutral MSH6 P52701 A159P 159 A P 0.3 Neutral MSH6 P52701 A159Q 159 A Q 0.302 Neutral MSH6 P52701 A159R 159 A R 0.298 Neutral MSH6 P52701 A159S 159 A S 0.156 Neutral MSH6 P52701 A159T 159 A T 0.014 Neutral MSH6 P52701 A159V 159 A V 0.04 Neutral MSH6 P52701 A159W 159 A W 0.504 Pathogenic MSH6 P52701 A159Y 159 A Y 0.482 Neutral MSH6 P52701 A16C 16 A C 0.182 Neutral MSH6 P52701 A16D 16 A D 0.266 Neutral MSH6 P52701 A16E 16 A E 0.306 Neutral MSH6 P52701 A16F 16 A F 0.468 Neutral MSH6 P52701 A16G 16 A G 0.006 Neutral MSH6 P52701 A16H 16 A H 0.264 Neutral MSH6 P52701 A16I 16 A I 0.406 Neutral MSH6 P52701 A16K 16 A K 0.354 Neutral MSH6 P52701 A16L 16 A L 0.4 Neutral MSH6 P52701 A16M 16 A M 0.29 Neutral MSH6 P52701 A16N 16 A N 0.296 Neutral MSH6 P52701 A16P 16 A P 0.036 Neutral MSH6 P52701 A16Q 16 A Q 0.302 Neutral MSH6 P52701 A16R 16 A R 0.36 Neutral MSH6 P52701 A16S 16 A S 0.068 Neutral MSH6 P52701 A16T 16 A T 0.166 Neutral MSH6 P52701 A16V 16 A V 0.242 Neutral MSH6 P52701 A16W 16 A W 0.504 Pathogenic MSH6 P52701 A16Y 16 A Y 0.5 Pathogenic MSH6 P52701 Q160A 160 Q A 0.1 Neutral MSH6 P52701 Q160C 160 Q C 0.082 Neutral MSH6 P52701 Q160D 160 Q D 0.088 Neutral MSH6 P52701 Q160E 160 Q E 0.122 Neutral MSH6 P52701 Q160F 160 Q F 0.278 Neutral MSH6 P52701 Q160G 160 Q G 0.14 Neutral MSH6 P52701 Q160H 160 Q H 0.22 Neutral MSH6 P52701 Q160I 160 Q I 0.296 Neutral MSH6 P52701 Q160K 160 Q K 0.02 Neutral MSH6 P52701 Q160L 160 Q L 0.35 Neutral MSH6 P52701 Q160M 160 Q M 0.104 Neutral MSH6 P52701 Q160N 160 Q N 0.094 Neutral MSH6 P52701 Q160P 160 Q P 0.31 Neutral MSH6 P52701 Q160R 160 Q R 0.026 Neutral MSH6 P52701 Q160S 160 Q S 0.054 Neutral MSH6 P52701 Q160T 160 Q T 0.146 Neutral MSH6 P52701 Q160V 160 Q V 0.284 Neutral MSH6 P52701 Q160W 160 Q W 0.46 Neutral MSH6 P52701 Q160Y 160 Q Y 0.4 Neutral MSH6 P52701 K161A 161 K A 0.054 Neutral MSH6 P52701 K161C 161 K C 0.028 Neutral MSH6 P52701 K161D 161 K D 0.05 Neutral MSH6 P52701 K161E 161 K E 0.072 Neutral MSH6 P52701 K161F 161 K F 0.23 Neutral MSH6 P52701 K161G 161 K G 0.044 Neutral MSH6 P52701 K161H 161 K H 0.048 Neutral MSH6 P52701 K161I 161 K I 0.222 Neutral MSH6 P52701 K161L 161 K L 0.214 Neutral MSH6 P52701 K161M 161 K M 0.106 Neutral MSH6 P52701 K161N 161 K N 0.082 Neutral MSH6 P52701 K161P 161 K P 0.016 Neutral MSH6 P52701 K161Q 161 K Q 0.09 Neutral MSH6 P52701 K161R 161 K R 0.002 Neutral MSH6 P52701 K161S 161 K S 0.22 Neutral MSH6 P52701 K161T 161 K T 0.012 Neutral MSH6 P52701 K161V 161 K V 0.184 Neutral MSH6 P52701 K161W 161 K W 0.396 Neutral MSH6 P52701 K161Y 161 K Y 0.326 Neutral MSH6 P52701 G162A 162 G A 0.16 Neutral MSH6 P52701 G162C 162 G C 0.34 Neutral MSH6 P52701 G162D 162 G D 0.426 Neutral MSH6 P52701 G162E 162 G E 0.56 Pathogenic MSH6 P52701 G162F 162 G F 0.758 Pathogenic MSH6 P52701 G162H 162 G H 0.7 Pathogenic MSH6 P52701 G162I 162 G I 0.676 Pathogenic MSH6 P52701 G162K 162 G K 0.682 Pathogenic MSH6 P52701 G162L 162 G L 0.674 Pathogenic MSH6 P52701 G162M 162 G M 0.69 Pathogenic MSH6 P52701 G162N 162 G N 0.422 Neutral MSH6 P52701 G162P 162 G P 0.634 Pathogenic MSH6 P52701 G162Q 162 G Q 0.45 Neutral MSH6 P52701 G162R 162 G R 0.75 Pathogenic MSH6 P52701 G162S 162 G S 0.302 Neutral MSH6 P52701 G162T 162 G T 0.46 Neutral MSH6 P52701 G162V 162 G V 0.652 Pathogenic MSH6 P52701 G162W 162 G W 0.758 Pathogenic MSH6 P52701 G162Y 162 G Y 0.744 Pathogenic MSH6 P52701 G163A 163 G A 0.166 Neutral MSH6 P52701 G163C 163 G C 0.344 Neutral MSH6 P52701 G163D 163 G D 0.434 Neutral MSH6 P52701 G163E 163 G E 0.344 Neutral MSH6 P52701 G163F 163 G F 0.772 Pathogenic MSH6 P52701 G163H 163 G H 0.716 Pathogenic MSH6 P52701 G163I 163 G I 0.688 Pathogenic MSH6 P52701 G163K 163 G K 0.64 Pathogenic MSH6 P52701 G163L 163 G L 0.688 Pathogenic MSH6 P52701 G163M 163 G M 0.412 Neutral MSH6 P52701 G163N 163 G N 0.428 Neutral MSH6 P52701 G163P 163 G P 0.646 Pathogenic MSH6 P52701 G163Q 163 G Q 0.46 Neutral MSH6 P52701 G163R 163 G R 0.764 Pathogenic MSH6 P52701 G163S 163 G S 0.296 Neutral MSH6 P52701 G163T 163 G T 0.478 Neutral MSH6 P52701 G163V 163 G V 0.668 Pathogenic MSH6 P52701 G163W 163 G W 0.77 Pathogenic MSH6 P52701 G163Y 163 G Y 0.754 Pathogenic MSH6 P52701 H164A 164 H A 0.108 Neutral MSH6 P52701 H164C 164 H C 0.042 Neutral MSH6 P52701 H164D 164 H D 0.028 Neutral MSH6 P52701 H164E 164 H E 0.058 Neutral MSH6 P52701 H164F 164 H F 0.032 Neutral MSH6 P52701 H164G 164 H G 0.11 Neutral MSH6 P52701 H164I 164 H I 0.258 Neutral MSH6 P52701 H164K 164 H K 0.026 Neutral MSH6 P52701 H164L 164 H L 0.02 Neutral MSH6 P52701 H164M 164 H M 0.014 Neutral MSH6 P52701 H164N 164 H N 0.058 Neutral MSH6 P52701 H164P 164 H P 0.042 Neutral MSH6 P52701 H164Q 164 H Q 0.056 Neutral MSH6 P52701 H164R 164 H R 0.046 Neutral MSH6 P52701 H164S 164 H S 0.154 Neutral MSH6 P52701 H164T 164 H T 0.186 Neutral MSH6 P52701 H164V 164 H V 0.016 Neutral MSH6 P52701 H164W 164 H W 0.398 Neutral MSH6 P52701 H164Y 164 H Y 0.252 Neutral MSH6 P52701 F165A 165 F A 0.126 Neutral MSH6 P52701 F165C 165 F C 0.092 Neutral MSH6 P52701 F165D 165 F D 0.234 Neutral MSH6 P52701 F165E 165 F E 0.272 Neutral MSH6 P52701 F165G 165 F G 0.194 Neutral MSH6 P52701 F165H 165 F H 0.02 Neutral MSH6 P52701 F165I 165 F I 0.088 Neutral MSH6 P52701 F165K 165 F K 0.258 Neutral MSH6 P52701 F165L 165 F L 0.078 Neutral MSH6 P52701 F165M 165 F M 0.124 Neutral MSH6 P52701 F165N 165 F N 0.246 Neutral MSH6 P52701 F165P 165 F P 0.268 Neutral MSH6 P52701 F165Q 165 F Q 0.248 Neutral MSH6 P52701 F165R 165 F R 0.224 Neutral MSH6 P52701 F165S 165 F S 0.222 Neutral MSH6 P52701 F165T 165 F T 0.23 Neutral MSH6 P52701 F165V 165 F V 0.228 Neutral MSH6 P52701 F165W 165 F W 0.46 Neutral MSH6 P52701 F165Y 165 F Y 0.03 Neutral MSH6 P52701 Y166A 166 Y A 0.116 Neutral MSH6 P52701 Y166C 166 Y C 0.112 Neutral MSH6 P52701 Y166D 166 Y D 0.166 Neutral MSH6 P52701 Y166E 166 Y E 0.184 Neutral MSH6 P52701 Y166F 166 Y F 0.01 Neutral MSH6 P52701 Y166G 166 Y G 0.122 Neutral MSH6 P52701 Y166H 166 Y H 0.002 Neutral MSH6 P52701 Y166I 166 Y I 0.094 Neutral MSH6 P52701 Y166K 166 Y K 0.174 Neutral MSH6 P52701 Y166L 166 Y L 0.04 Neutral MSH6 P52701 Y166M 166 Y M 0.078 Neutral MSH6 P52701 Y166N 166 Y N 0.116 Neutral MSH6 P52701 Y166P 166 Y P 0.072 Neutral MSH6 P52701 Y166Q 166 Y Q 0.11 Neutral MSH6 P52701 Y166R 166 Y R 0.164 Neutral MSH6 P52701 Y166S 166 Y S 0.12 Neutral MSH6 P52701 Y166T 166 Y T 0.126 Neutral MSH6 P52701 Y166V 166 Y V 0.162 Neutral MSH6 P52701 Y166W 166 Y W 0.05 Neutral MSH6 P52701 S167A 167 S A 0.062 Neutral MSH6 P52701 S167C 167 S C 0.002 Neutral MSH6 P52701 S167D 167 S D 0.07 Neutral MSH6 P52701 S167E 167 S E 0.23 Neutral MSH6 P52701 S167F 167 S F 0.428 Neutral MSH6 P52701 S167G 167 S G 0.078 Neutral MSH6 P52701 S167H 167 S H 0.364 Neutral MSH6 P52701 S167I 167 S I 0.086 Neutral MSH6 P52701 S167K 167 S K 0.29 Neutral MSH6 P52701 S167L 167 S L 0.088 Neutral MSH6 P52701 S167M 167 S M 0.506 Pathogenic MSH6 P52701 S167N 167 S N 0.004 Neutral MSH6 P52701 S167P 167 S P 0.15 Neutral MSH6 P52701 S167Q 167 S Q 0.266 Neutral MSH6 P52701 S167R 167 S R 0.37 Neutral MSH6 P52701 S167T 167 S T 0.02 Neutral MSH6 P52701 S167V 167 S V 0.302 Neutral MSH6 P52701 S167W 167 S W 0.64 Pathogenic MSH6 P52701 S167Y 167 S Y 0.598 Pathogenic MSH6 P52701 A168C 168 A C 0.182 Neutral MSH6 P52701 A168D 168 A D 0.33 Neutral MSH6 P52701 A168E 168 A E 0.286 Neutral MSH6 P52701 A168F 168 A F 0.468 Neutral MSH6 P52701 A168G 168 A G 0.004 Neutral MSH6 P52701 A168H 168 A H 0.26 Neutral MSH6 P52701 A168I 168 A I 0.406 Neutral MSH6 P52701 A168K 168 A K 0.354 Neutral MSH6 P52701 A168L 168 A L 0.354 Neutral MSH6 P52701 A168M 168 A M 0.256 Neutral MSH6 P52701 A168N 168 A N 0.296 Neutral MSH6 P52701 A168P 168 A P 0.076 Neutral MSH6 P52701 A168Q 168 A Q 0.302 Neutral MSH6 P52701 A168R 168 A R 0.36 Neutral MSH6 P52701 A168S 168 A S 0.006 Neutral MSH6 P52701 A168T 168 A T 0.018 Neutral MSH6 P52701 A168V 168 A V 0.242 Neutral MSH6 P52701 A168W 168 A W 0.504 Pathogenic MSH6 P52701 A168Y 168 A Y 0.5 Pathogenic MSH6 P52701 K169A 169 K A 0.056 Neutral MSH6 P52701 K169C 169 K C 0.03 Neutral MSH6 P52701 K169D 169 K D 0.068 Neutral MSH6 P52701 K169E 169 K E 0.01 Neutral MSH6 P52701 K169F 169 K F 0.242 Neutral MSH6 P52701 K169G 169 K G 0.136 Neutral MSH6 P52701 K169H 169 K H 0.05 Neutral MSH6 P52701 K169I 169 K I 0.258 Neutral MSH6 P52701 K169L 169 K L 0.244 Neutral MSH6 P52701 K169M 169 K M 0.112 Neutral MSH6 P52701 K169N 169 K N 0.006 Neutral MSH6 P52701 K169P 169 K P 0.084 Neutral MSH6 P52701 K169Q 169 K Q 0.048 Neutral MSH6 P52701 K169R 169 K R 0.004 Neutral MSH6 P52701 K169S 169 K S 0.22 Neutral MSH6 P52701 K169T 169 K T 0.182 Neutral MSH6 P52701 K169V 169 K V 0.194 Neutral MSH6 P52701 K169W 169 K W 0.49 Neutral MSH6 P52701 K169Y 169 K Y 0.41 Neutral MSH6 P52701 L17A 17 L A 0.088 Neutral MSH6 P52701 L17C 17 L C 0.094 Neutral MSH6 P52701 L17D 17 L D 0.158 Neutral MSH6 P52701 L17E 17 L E 0.144 Neutral MSH6 P52701 L17F 17 L F 0.242 Neutral MSH6 P52701 L17G 17 L G 0.184 Neutral MSH6 P52701 L17H 17 L H 0.084 Neutral MSH6 P52701 L17I 17 L I 0.03 Neutral MSH6 P52701 L17K 17 L K 0.022 Neutral MSH6 P52701 L17M 17 L M 0.132 Neutral MSH6 P52701 L17N 17 L N 0.148 Neutral MSH6 P52701 L17P 17 L P 0.096 Neutral MSH6 P52701 L17Q 17 L Q 0.064 Neutral MSH6 P52701 L17R 17 L R 0.28 Neutral MSH6 P52701 L17S 17 L S 0.134 Neutral MSH6 P52701 L17T 17 L T 0.112 Neutral MSH6 P52701 L17V 17 L V 0.114 Neutral MSH6 P52701 L17W 17 L W 0.334 Neutral MSH6 P52701 L17Y 17 L Y 0.284 Neutral MSH6 P52701 P170A 170 P A 0.196 Neutral MSH6 P52701 P170C 170 P C 0.18 Neutral MSH6 P52701 P170D 170 P D 0.03 Neutral MSH6 P52701 P170E 170 P E 0.244 Neutral MSH6 P52701 P170F 170 P F 0.382 Neutral MSH6 P52701 P170G 170 P G 0.078 Neutral MSH6 P52701 P170H 170 P H 0.364 Neutral MSH6 P52701 P170I 170 P I 0.142 Neutral MSH6 P52701 P170K 170 P K 0.282 Neutral MSH6 P52701 P170L 170 P L 0.124 Neutral MSH6 P52701 P170M 170 P M 0.3 Neutral MSH6 P52701 P170N 170 P N 0.018 Neutral MSH6 P52701 P170Q 170 P Q 0.286 Neutral MSH6 P52701 P170R 170 P R 0.308 Neutral MSH6 P52701 P170S 170 P S 0.002 Neutral MSH6 P52701 P170T 170 P T 0.088 Neutral MSH6 P52701 P170V 170 P V 0.166 Neutral MSH6 P52701 P170W 170 P W 0.482 Neutral MSH6 P52701 P170Y 170 P Y 0.368 Neutral MSH6 P52701 E171A 171 E A 0.144 Neutral MSH6 P52701 E171C 171 E C 0.064 Neutral MSH6 P52701 E171D 171 E D 0.004 Neutral MSH6 P52701 E171F 171 E F 0.272 Neutral MSH6 P52701 E171G 171 E G 0.084 Neutral MSH6 P52701 E171H 171 E H 0.104 Neutral MSH6 P52701 E171I 171 E I 0.284 Neutral MSH6 P52701 E171K 171 E K 0.026 Neutral MSH6 P52701 E171L 171 E L 0.138 Neutral MSH6 P52701 E171M 171 E M 0.164 Neutral MSH6 P52701 E171N 171 E N 0.056 Neutral MSH6 P52701 E171P 171 E P 0.3 Neutral MSH6 P52701 E171Q 171 E Q 0.012 Neutral MSH6 P52701 E171R 171 E R 0.046 Neutral MSH6 P52701 E171S 171 E S 0.058 Neutral MSH6 P52701 E171T 171 E T 0.168 Neutral MSH6 P52701 E171V 171 E V 0.032 Neutral MSH6 P52701 E171W 171 E W 0.43 Neutral MSH6 P52701 E171Y 171 E Y 0.338 Neutral MSH6 P52701 I172A 172 I A 0.074 Neutral MSH6 P52701 I172C 172 I C 0.118 Neutral MSH6 P52701 I172D 172 I D 0.218 Neutral MSH6 P52701 I172E 172 I E 0.208 Neutral MSH6 P52701 I172F 172 I F 0.342 Neutral MSH6 P52701 I172G 172 I G 0.278 Neutral MSH6 P52701 I172H 172 I H 0.146 Neutral MSH6 P52701 I172K 172 I K 0.238 Neutral MSH6 P52701 I172L 172 I L 0.202 Neutral MSH6 P52701 I172M 172 I M 0.166 Neutral MSH6 P52701 I172N 172 I N 0.188 Neutral MSH6 P52701 I172P 172 I P 0.252 Neutral MSH6 P52701 I172Q 172 I Q 0.258 Neutral MSH6 P52701 I172R 172 I R 0.47 Neutral MSH6 P52701 I172S 172 I S 0.216 Neutral MSH6 P52701 I172T 172 I T 0.164 Neutral MSH6 P52701 I172V 172 I V 0.004 Neutral MSH6 P52701 I172W 172 I W 0.484 Neutral MSH6 P52701 I172Y 172 I Y 0.496 Neutral MSH6 P52701 L173A 173 L A 0.088 Neutral MSH6 P52701 L173C 173 L C 0.094 Neutral MSH6 P52701 L173D 173 L D 0.158 Neutral MSH6 P52701 L173E 173 L E 0.106 Neutral MSH6 P52701 L173F 173 L F 0.21 Neutral MSH6 P52701 L173G 173 L G 0.184 Neutral MSH6 P52701 L173H 173 L H 0.04 Neutral MSH6 P52701 L173I 173 L I 0.072 Neutral MSH6 P52701 L173K 173 L K 0.02 Neutral MSH6 P52701 L173M 173 L M 0.132 Neutral MSH6 P52701 L173N 173 L N 0.138 Neutral MSH6 P52701 L173P 173 L P 0.216 Neutral MSH6 P52701 L173Q 173 L Q 0.004 Neutral MSH6 P52701 L173R 173 L R 0.25 Neutral MSH6 P52701 L173S 173 L S 0.134 Neutral MSH6 P52701 L173T 173 L T 0.112 Neutral MSH6 P52701 L173V 173 L V 0.114 Neutral MSH6 P52701 L173W 173 L W 0.334 Neutral MSH6 P52701 L173Y 173 L Y 0.284 Neutral MSH6 P52701 R174A 174 R A 0.08 Neutral MSH6 P52701 R174C 174 R C 0.148 Neutral MSH6 P52701 R174D 174 R D 0.024 Neutral MSH6 P52701 R174E 174 R E 0.162 Neutral MSH6 P52701 R174F 174 R F 0.28 Neutral MSH6 P52701 R174G 174 R G 0.1 Neutral MSH6 P52701 R174H 174 R H 0.142 Neutral MSH6 P52701 R174I 174 R I 0.308 Neutral MSH6 P52701 R174K 174 R K 0.004 Neutral MSH6 P52701 R174L 174 R L 0.272 Neutral MSH6 P52701 R174M 174 R M 0.164 Neutral MSH6 P52701 R174N 174 R N 0.07 Neutral MSH6 P52701 R174P 174 R P 0.236 Neutral MSH6 P52701 R174Q 174 R Q 0.012 Neutral MSH6 P52701 R174S 174 R S 0.164 Neutral MSH6 P52701 R174T 174 R T 0.142 Neutral MSH6 P52701 R174V 174 R V 0.242 Neutral MSH6 P52701 R174W 174 R W 0.448 Neutral MSH6 P52701 R174Y 174 R Y 0.284 Neutral MSH6 P52701 A175C 175 A C 0.332 Neutral MSH6 P52701 A175D 175 A D 0.464 Neutral MSH6 P52701 A175E 175 A E 0.49 Neutral MSH6 P52701 A175F 175 A F 0.728 Pathogenic MSH6 P52701 A175G 175 A G 0.006 Neutral MSH6 P52701 A175H 175 A H 0.51 Pathogenic MSH6 P52701 A175I 175 A I 0.672 Pathogenic MSH6 P52701 A175K 175 A K 0.426 Neutral MSH6 P52701 A175L 175 A L 0.662 Pathogenic MSH6 P52701 A175M 175 A M 0.49 Neutral MSH6 P52701 A175N 175 A N 0.464 Neutral MSH6 P52701 A175P 175 A P 0.466 Neutral MSH6 P52701 A175Q 175 A Q 0.492 Neutral MSH6 P52701 A175R 175 A R 0.55 Pathogenic MSH6 P52701 A175S 175 A S 0.166 Neutral MSH6 P52701 A175T 175 A T 0.272 Neutral MSH6 P52701 A175V 175 A V 0.382 Neutral MSH6 P52701 A175W 175 A W 0.758 Pathogenic MSH6 P52701 A175Y 175 A Y 0.762 Pathogenic MSH6 P52701 M176A 176 M A 0.046 Neutral MSH6 P52701 M176C 176 M C 0.032 Neutral MSH6 P52701 M176D 176 M D 0.166 Neutral MSH6 P52701 M176E 176 M E 0.066 Neutral MSH6 P52701 M176F 176 M F 0.266 Neutral MSH6 P52701 M176G 176 M G 0.122 Neutral MSH6 P52701 M176H 176 M H 0.058 Neutral MSH6 P52701 M176I 176 M I 0.06 Neutral MSH6 P52701 M176K 176 M K 0.048 Neutral MSH6 P52701 M176L 176 M L 0.068 Neutral MSH6 P52701 M176N 176 M N 0.192 Neutral MSH6 P52701 M176P 176 M P 0.23 Neutral MSH6 P52701 M176Q 176 M Q 0.068 Neutral MSH6 P52701 M176R 176 M R 0.142 Neutral MSH6 P52701 M176S 176 M S 0.188 Neutral MSH6 P52701 M176T 176 M T 0.008 Neutral MSH6 P52701 M176V 176 M V 0.136 Neutral MSH6 P52701 M176W 176 M W 0.472 Neutral MSH6 P52701 M176Y 176 M Y 0.38 Neutral MSH6 P52701 Q177A 177 Q A 0.036 Neutral MSH6 P52701 Q177C 177 Q C 0.082 Neutral MSH6 P52701 Q177D 177 Q D 0.046 Neutral MSH6 P52701 Q177E 177 Q E 0.008 Neutral MSH6 P52701 Q177F 177 Q F 0.26 Neutral MSH6 P52701 Q177G 177 Q G 0.136 Neutral MSH6 P52701 Q177H 177 Q H 0.214 Neutral MSH6 P52701 Q177I 177 Q I 0.354 Neutral MSH6 P52701 Q177K 177 Q K 0.02 Neutral MSH6 P52701 Q177L 177 Q L 0.332 Neutral MSH6 P52701 Q177M 177 Q M 0.186 Neutral MSH6 P52701 Q177N 177 Q N 0.064 Neutral MSH6 P52701 Q177P 177 Q P 0.294 Neutral MSH6 P52701 Q177R 177 Q R 0.04 Neutral MSH6 P52701 Q177S 177 Q S 0.176 Neutral MSH6 P52701 Q177T 177 Q T 0.13 Neutral MSH6 P52701 Q177V 177 Q V 0.092 Neutral MSH6 P52701 Q177W 177 Q W 0.42 Neutral MSH6 P52701 Q177Y 177 Q Y 0.362 Neutral MSH6 P52701 R178A 178 R A 0.086 Neutral MSH6 P52701 R178C 178 R C 0.14 Neutral MSH6 P52701 R178D 178 R D 0.074 Neutral MSH6 P52701 R178E 178 R E 0.02 Neutral MSH6 P52701 R178F 178 R F 0.28 Neutral MSH6 P52701 R178G 178 R G 0.072 Neutral MSH6 P52701 R178H 178 R H 0.142 Neutral MSH6 P52701 R178I 178 R I 0.116 Neutral MSH6 P52701 R178K 178 R K 0.172 Neutral MSH6 P52701 R178L 178 R L 0.012 Neutral MSH6 P52701 R178M 178 R M 0.002 Neutral MSH6 P52701 R178N 178 R N 0.198 Neutral MSH6 P52701 R178P 178 R P 0.262 Neutral MSH6 P52701 R178Q 178 R Q 0.012 Neutral MSH6 P52701 R178S 178 R S 0.062 Neutral MSH6 P52701 R178T 178 R T 0.164 Neutral MSH6 P52701 R178V 178 R V 0.242 Neutral MSH6 P52701 R178W 178 R W 0.384 Neutral MSH6 P52701 R178Y 178 R Y 0.284 Neutral MSH6 P52701 A179C 179 A C 0.326 Neutral MSH6 P52701 A179D 179 A D 0.458 Neutral MSH6 P52701 A179E 179 A E 0.37 Neutral MSH6 P52701 A179F 179 A F 0.722 Pathogenic MSH6 P52701 A179G 179 A G 0.224 Neutral MSH6 P52701 A179H 179 A H 0.504 Pathogenic MSH6 P52701 A179I 179 A I 0.666 Pathogenic MSH6 P52701 A179K 179 A K 0.552 Pathogenic MSH6 P52701 A179L 179 A L 0.656 Pathogenic MSH6 P52701 A179M 179 A M 0.484 Neutral MSH6 P52701 A179N 179 A N 0.488 Neutral MSH6 P52701 A179P 179 A P 0.46 Neutral MSH6 P52701 A179Q 179 A Q 0.488 Neutral MSH6 P52701 A179R 179 A R 0.582 Pathogenic MSH6 P52701 A179S 179 A S 0.082 Neutral MSH6 P52701 A179T 179 A T 0.284 Neutral MSH6 P52701 A179V 179 A V 0.376 Neutral MSH6 P52701 A179W 179 A W 0.754 Pathogenic MSH6 P52701 A179Y 179 A Y 0.758 Pathogenic MSH6 P52701 S18A 18 S A 0.052 Neutral MSH6 P52701 S18C 18 S C 0.022 Neutral MSH6 P52701 S18D 18 S D 0.044 Neutral MSH6 P52701 S18E 18 S E 0.148 Neutral MSH6 P52701 S18F 18 S F 0.264 Neutral MSH6 P52701 S18G 18 S G 0.036 Neutral MSH6 P52701 S18H 18 S H 0.238 Neutral MSH6 P52701 S18I 18 S I 0.026 Neutral MSH6 P52701 S18K 18 S K 0.164 Neutral MSH6 P52701 S18L 18 S L 0.068 Neutral MSH6 P52701 S18M 18 S M 0.332 Neutral MSH6 P52701 S18N 18 S N 0.002 Neutral MSH6 P52701 S18P 18 S P 0.132 Neutral MSH6 P52701 S18Q 18 S Q 0.158 Neutral MSH6 P52701 S18R 18 S R 0.248 Neutral MSH6 P52701 S18T 18 S T 0.176 Neutral MSH6 P52701 S18V 18 S V 0.032 Neutral MSH6 P52701 S18W 18 S W 0.49 Neutral MSH6 P52701 S18Y 18 S Y 0.448 Neutral MSH6 P52701 D180A 180 D A 0.126 Neutral MSH6 P52701 D180C 180 D C 0.256 Neutral MSH6 P52701 D180E 180 D E 0.02 Neutral MSH6 P52701 D180F 180 D F 0.62 Pathogenic MSH6 P52701 D180G 180 D G 0.198 Neutral MSH6 P52701 D180H 180 D H 0.154 Neutral MSH6 P52701 D180I 180 D I 0.432 Neutral MSH6 P52701 D180K 180 D K 0.148 Neutral MSH6 P52701 D180L 180 D L 0.424 Neutral MSH6 P52701 D180M 180 D M 0.332 Neutral MSH6 P52701 D180N 180 D N 0.092 Neutral MSH6 P52701 D180P 180 D P 0.444 Neutral MSH6 P52701 D180Q 180 D Q 0.234 Neutral MSH6 P52701 D180R 180 D R 0.34 Neutral MSH6 P52701 D180S 180 D S 0.216 Neutral MSH6 P52701 D180T 180 D T 0.19 Neutral MSH6 P52701 D180V 180 D V 0.396 Neutral MSH6 P52701 D180W 180 D W 0.706 Pathogenic MSH6 P52701 D180Y 180 D Y 0.678 Pathogenic MSH6 P52701 E181A 181 E A 0.066 Neutral MSH6 P52701 E181C 181 E C 0.068 Neutral MSH6 P52701 E181D 181 E D 0 Neutral MSH6 P52701 E181F 181 E F 0.272 Neutral MSH6 P52701 E181G 181 E G 0 Neutral MSH6 P52701 E181H 181 E H 0.104 Neutral MSH6 P52701 E181I 181 E I 0.284 Neutral MSH6 P52701 E181K 181 E K 0.006 Neutral MSH6 P52701 E181L 181 E L 0.286 Neutral MSH6 P52701 E181M 181 E M 0.164 Neutral MSH6 P52701 E181N 181 E N 0.002 Neutral MSH6 P52701 E181P 181 E P 0.3 Neutral MSH6 P52701 E181Q 181 E Q 0.012 Neutral MSH6 P52701 E181R 181 E R 0.046 Neutral MSH6 P52701 E181S 181 E S 0.018 Neutral MSH6 P52701 E181T 181 E T 0.14 Neutral MSH6 P52701 E181V 181 E V 0.142 Neutral MSH6 P52701 E181W 181 E W 0.43 Neutral MSH6 P52701 E181Y 181 E Y 0.338 Neutral MSH6 P52701 A182C 182 A C 0.324 Neutral MSH6 P52701 A182D 182 A D 0.52 Pathogenic MSH6 P52701 A182E 182 A E 0.48 Neutral MSH6 P52701 A182F 182 A F 0.646 Pathogenic MSH6 P52701 A182G 182 A G 0.186 Neutral MSH6 P52701 A182H 182 A H 0.5 Pathogenic MSH6 P52701 A182I 182 A I 0.658 Pathogenic MSH6 P52701 A182K 182 A K 0.58 Pathogenic MSH6 P52701 A182L 182 A L 0.644 Pathogenic MSH6 P52701 A182M 182 A M 0.482 Neutral MSH6 P52701 A182N 182 A N 0.456 Neutral MSH6 P52701 A182P 182 A P 0.206 Neutral MSH6 P52701 A182Q 182 A Q 0.462 Neutral MSH6 P52701 A182R 182 A R 0.574 Pathogenic MSH6 P52701 A182S 182 A S 0.03 Neutral MSH6 P52701 A182T 182 A T 0.282 Neutral MSH6 P52701 A182V 182 A V 0.058 Neutral MSH6 P52701 A182W 182 A W 0.742 Pathogenic MSH6 P52701 A182Y 182 A Y 0.744 Pathogenic MSH6 P52701 L183A 183 L A 0.088 Neutral MSH6 P52701 L183C 183 L C 0.094 Neutral MSH6 P52701 L183D 183 L D 0.168 Neutral MSH6 P52701 L183E 183 L E 0.154 Neutral MSH6 P52701 L183F 183 L F 0.268 Neutral MSH6 P52701 L183G 183 L G 0.188 Neutral MSH6 P52701 L183H 183 L H 0.084 Neutral MSH6 P52701 L183I 183 L I 0.002 Neutral MSH6 P52701 L183K 183 L K 0.046 Neutral MSH6 P52701 L183M 183 L M 0.01 Neutral MSH6 P52701 L183N 183 L N 0.146 Neutral MSH6 P52701 L183P 183 L P 0.25 Neutral MSH6 P52701 L183Q 183 L Q 0.064 Neutral MSH6 P52701 L183R 183 L R 0.324 Neutral MSH6 P52701 L183S 183 L S 0.206 Neutral MSH6 P52701 L183T 183 L T 0.114 Neutral MSH6 P52701 L183V 183 L V 0.172 Neutral MSH6 P52701 L183W 183 L W 0.37 Neutral MSH6 P52701 L183Y 183 L Y 0.322 Neutral MSH6 P52701 N184A 184 N A 0.004 Neutral MSH6 P52701 N184C 184 N C 0.148 Neutral MSH6 P52701 N184D 184 N D 0.118 Neutral MSH6 P52701 N184E 184 N E 0.016 Neutral MSH6 P52701 N184F 184 N F 0.226 Neutral MSH6 P52701 N184G 184 N G 0.16 Neutral MSH6 P52701 N184H 184 N H 0.262 Neutral MSH6 P52701 N184I 184 N I 0.266 Neutral MSH6 P52701 N184K 184 N K 0.042 Neutral MSH6 P52701 N184L 184 N L 0.272 Neutral MSH6 P52701 N184M 184 N M 0.22 Neutral MSH6 P52701 N184P 184 N P 0.228 Neutral MSH6 P52701 N184Q 184 N Q 0.038 Neutral MSH6 P52701 N184R 184 N R 0.148 Neutral MSH6 P52701 N184S 184 N S 0 Neutral MSH6 P52701 N184T 184 N T 0.024 Neutral MSH6 P52701 N184V 184 N V 0.262 Neutral MSH6 P52701 N184W 184 N W 0.446 Neutral MSH6 P52701 N184Y 184 N Y 0.402 Neutral MSH6 P52701 K185A 185 K A 0.096 Neutral MSH6 P52701 K185C 185 K C 0.028 Neutral MSH6 P52701 K185D 185 K D 0.002 Neutral MSH6 P52701 K185E 185 K E 0.004 Neutral MSH6 P52701 K185F 185 K F 0.212 Neutral MSH6 P52701 K185G 185 K G 0.13 Neutral MSH6 P52701 K185H 185 K H 0.018 Neutral MSH6 P52701 K185I 185 K I 0.124 Neutral MSH6 P52701 K185L 185 K L 0.036 Neutral MSH6 P52701 K185M 185 K M 0.078 Neutral MSH6 P52701 K185N 185 K N 0.05 Neutral MSH6 P52701 K185P 185 K P 0.214 Neutral MSH6 P52701 K185Q 185 K Q 0.01 Neutral MSH6 P52701 K185R 185 K R 0.016 Neutral MSH6 P52701 K185S 185 K S 0.176 Neutral MSH6 P52701 K185T 185 K T 0.18 Neutral MSH6 P52701 K185V 185 K V 0.184 Neutral MSH6 P52701 K185W 185 K W 0.396 Neutral MSH6 P52701 K185Y 185 K Y 0.326 Neutral MSH6 P52701 D186A 186 D A 0.082 Neutral MSH6 P52701 D186C 186 D C 0.156 Neutral MSH6 P52701 D186E 186 D E 0.014 Neutral MSH6 P52701 D186F 186 D F 0.388 Neutral MSH6 P52701 D186G 186 D G 0.172 Neutral MSH6 P52701 D186H 186 D H 0.096 Neutral MSH6 P52701 D186I 186 D I 0.312 Neutral MSH6 P52701 D186K 186 D K 0.052 Neutral MSH6 P52701 D186L 186 D L 0.27 Neutral MSH6 P52701 D186M 186 D M 0.198 Neutral MSH6 P52701 D186N 186 D N 0.058 Neutral MSH6 P52701 D186P 186 D P 0.322 Neutral MSH6 P52701 D186Q 186 D Q 0.114 Neutral MSH6 P52701 D186R 186 D R 0.134 Neutral MSH6 P52701 D186S 186 D S 0.002 Neutral MSH6 P52701 D186T 186 D T 0.016 Neutral MSH6 P52701 D186V 186 D V 0.27 Neutral MSH6 P52701 D186W 186 D W 0.452 Neutral MSH6 P52701 D186Y 186 D Y 0.398 Neutral MSH6 P52701 K187A 187 K A 0.054 Neutral MSH6 P52701 K187C 187 K C 0.028 Neutral MSH6 P52701 K187D 187 K D 0.066 Neutral MSH6 P52701 K187E 187 K E 0.072 Neutral MSH6 P52701 K187F 187 K F 0.23 Neutral MSH6 P52701 K187G 187 K G 0.132 Neutral MSH6 P52701 K187H 187 K H 0.048 Neutral MSH6 P52701 K187I 187 K I 0.222 Neutral MSH6 P52701 K187L 187 K L 0.148 Neutral MSH6 P52701 K187M 187 K M 0.078 Neutral MSH6 P52701 K187N 187 K N 0.082 Neutral MSH6 P52701 K187P 187 K P 0.01 Neutral MSH6 P52701 K187Q 187 K Q 0.09 Neutral MSH6 P52701 K187R 187 K R 0.002 Neutral MSH6 P52701 K187S 187 K S 0.176 Neutral MSH6 P52701 K187T 187 K T 0.092 Neutral MSH6 P52701 K187V 187 K V 0.022 Neutral MSH6 P52701 K187W 187 K W 0.396 Neutral MSH6 P52701 K187Y 187 K Y 0.326 Neutral MSH6 P52701 I188A 188 I A 0.06 Neutral MSH6 P52701 I188C 188 I C 0.09 Neutral MSH6 P52701 I188D 188 I D 0.088 Neutral MSH6 P52701 I188E 188 I E 0.03 Neutral MSH6 P52701 I188F 188 I F 0.206 Neutral MSH6 P52701 I188G 188 I G 0.23 Neutral MSH6 P52701 I188H 188 I H 0.08 Neutral MSH6 P52701 I188K 188 I K 0.042 Neutral MSH6 P52701 I188L 188 I L 0.108 Neutral MSH6 P52701 I188M 188 I M 0.166 Neutral MSH6 P52701 I188N 188 I N 0.158 Neutral MSH6 P52701 I188P 188 I P 0.096 Neutral MSH6 P52701 I188Q 188 I Q 0.108 Neutral MSH6 P52701 I188R 188 I R 0.232 Neutral MSH6 P52701 I188S 188 I S 0.072 Neutral MSH6 P52701 I188T 188 I T 0.002 Neutral MSH6 P52701 I188V 188 I V 0.022 Neutral MSH6 P52701 I188W 188 I W 0.344 Neutral MSH6 P52701 I188Y 188 I Y 0.298 Neutral MSH6 P52701 K189A 189 K A 0.054 Neutral MSH6 P52701 K189C 189 K C 0.028 Neutral MSH6 P52701 K189D 189 K D 0.002 Neutral MSH6 P52701 K189E 189 K E 0.004 Neutral MSH6 P52701 K189F 189 K F 0.25 Neutral MSH6 P52701 K189G 189 K G 0.134 Neutral MSH6 P52701 K189H 189 K H 0.048 Neutral MSH6 P52701 K189I 189 K I 0.248 Neutral MSH6 P52701 K189L 189 K L 0.166 Neutral MSH6 P52701 K189M 189 K M 0.112 Neutral MSH6 P52701 K189N 189 K N 0.082 Neutral MSH6 P52701 K189P 189 K P 0.254 Neutral MSH6 P52701 K189Q 189 K Q 0.024 Neutral MSH6 P52701 K189R 189 K R 0.066 Neutral MSH6 P52701 K189S 189 K S 0.22 Neutral MSH6 P52701 K189T 189 K T 0.182 Neutral MSH6 P52701 K189V 189 K V 0.192 Neutral MSH6 P52701 K189W 189 K W 0.482 Neutral MSH6 P52701 K189Y 189 K Y 0.4 Neutral MSH6 P52701 D19A 19 D A 0.014 Neutral MSH6 P52701 D19C 19 D C 0.148 Neutral MSH6 P52701 D19E 19 D E 0.12 Neutral MSH6 P52701 D19F 19 D F 0.37 Neutral MSH6 P52701 D19G 19 D G 0.14 Neutral MSH6 P52701 D19H 19 D H 0.09 Neutral MSH6 P52701 D19I 19 D I 0.262 Neutral MSH6 P52701 D19K 19 D K 0.052 Neutral MSH6 P52701 D19L 19 D L 0.262 Neutral MSH6 P52701 D19M 19 D M 0.19 Neutral MSH6 P52701 D19N 19 D N 0 Neutral MSH6 P52701 D19P 19 D P 0.038 Neutral MSH6 P52701 D19Q 19 D Q 0.112 Neutral MSH6 P52701 D19R 19 D R 0.166 Neutral MSH6 P52701 D19S 19 D S 0.002 Neutral MSH6 P52701 D19T 19 D T 0.1 Neutral MSH6 P52701 D19V 19 D V 0.242 Neutral MSH6 P52701 D19W 19 D W 0.434 Neutral MSH6 P52701 D19Y 19 D Y 0.404 Neutral MSH6 P52701 R190A 190 R A 0.144 Neutral MSH6 P52701 R190C 190 R C 0.242 Neutral MSH6 P52701 R190D 190 R D 0.258 Neutral MSH6 P52701 R190E 190 R E 0.028 Neutral MSH6 P52701 R190F 190 R F 0.45 Neutral MSH6 P52701 R190G 190 R G 0.128 Neutral MSH6 P52701 R190H 190 R H 0.182 Neutral MSH6 P52701 R190I 190 R I 0.474 Neutral MSH6 P52701 R190K 190 R K 0.27 Neutral MSH6 P52701 R190L 190 R L 0.436 Neutral MSH6 P52701 R190M 190 R M 0.246 Neutral MSH6 P52701 R190N 190 R N 0.252 Neutral MSH6 P52701 R190P 190 R P 0.378 Neutral MSH6 P52701 R190Q 190 R Q 0.322 Neutral MSH6 P52701 R190S 190 R S 0.204 Neutral MSH6 P52701 R190T 190 R T 0.21 Neutral MSH6 P52701 R190V 190 R V 0.306 Neutral MSH6 P52701 R190W 190 R W 0.622 Pathogenic MSH6 P52701 R190Y 190 R Y 0.45 Neutral MSH6 P52701 L191A 191 L A 0.074 Neutral MSH6 P52701 L191C 191 L C 0.13 Neutral MSH6 P52701 L191D 191 L D 0.23 Neutral MSH6 P52701 L191E 191 L E 0.226 Neutral MSH6 P52701 L191F 191 L F 0.366 Neutral MSH6 P52701 L191G 191 L G 0.242 Neutral MSH6 P52701 L191H 191 L H 0.122 Neutral MSH6 P52701 L191I 191 L I 0.056 Neutral MSH6 P52701 L191K 191 L K 0.032 Neutral MSH6 P52701 L191M 191 L M 0.23 Neutral MSH6 P52701 L191N 191 L N 0.06 Neutral MSH6 P52701 L191P 191 L P 0.334 Neutral MSH6 P52701 L191Q 191 L Q 0.1 Neutral MSH6 P52701 L191R 191 L R 0.496 Neutral MSH6 P52701 L191S 191 L S 0.102 Neutral MSH6 P52701 L191T 191 L T 0.17 Neutral MSH6 P52701 L191V 191 L V 0.23 Neutral MSH6 P52701 L191W 191 L W 0.526 Pathogenic MSH6 P52701 L191Y 191 L Y 0.488 Neutral MSH6 P52701 E192A 192 E A 0.212 Neutral MSH6 P52701 E192C 192 E C 0.068 Neutral MSH6 P52701 E192D 192 E D 0.038 Neutral MSH6 P52701 E192F 192 E F 0.286 Neutral MSH6 P52701 E192G 192 E G 0.084 Neutral MSH6 P52701 E192H 192 E H 0.106 Neutral MSH6 P52701 E192I 192 E I 0.302 Neutral MSH6 P52701 E192K 192 E K 0.002 Neutral MSH6 P52701 E192L 192 E L 0.3 Neutral MSH6 P52701 E192M 192 E M 0.172 Neutral MSH6 P52701 E192N 192 E N 0.04 Neutral MSH6 P52701 E192P 192 E P 0.314 Neutral MSH6 P52701 E192Q 192 E Q 0.012 Neutral MSH6 P52701 E192R 192 E R 0.016 Neutral MSH6 P52701 E192S 192 E S 0.17 Neutral MSH6 P52701 E192T 192 E T 0.022 Neutral MSH6 P52701 E192V 192 E V 0.264 Neutral MSH6 P52701 E192W 192 E W 0.476 Neutral MSH6 P52701 E192Y 192 E Y 0.374 Neutral MSH6 P52701 L193A 193 L A 0.124 Neutral MSH6 P52701 L193C 193 L C 0.13 Neutral MSH6 P52701 L193D 193 L D 0.234 Neutral MSH6 P52701 L193E 193 L E 0.172 Neutral MSH6 P52701 L193F 193 L F 0.348 Neutral MSH6 P52701 L193G 193 L G 0.156 Neutral MSH6 P52701 L193H 193 L H 0.122 Neutral MSH6 P52701 L193I 193 L I 0.04 Neutral MSH6 P52701 L193K 193 L K 0.24 Neutral MSH6 P52701 L193M 193 L M 0.012 Neutral MSH6 P52701 L193N 193 L N 0.224 Neutral MSH6 P52701 L193P 193 L P 0.332 Neutral MSH6 P52701 L193Q 193 L Q 0.074 Neutral MSH6 P52701 L193R 193 L R 0.476 Neutral MSH6 P52701 L193S 193 L S 0.252 Neutral MSH6 P52701 L193T 193 L T 0.166 Neutral MSH6 P52701 L193V 193 L V 0.168 Neutral MSH6 P52701 L193W 193 L W 0.512 Pathogenic MSH6 P52701 L193Y 193 L Y 0.468 Neutral MSH6 P52701 A194C 194 A C 0.1 Neutral MSH6 P52701 A194D 194 A D 0.338 Neutral MSH6 P52701 A194E 194 A E 0.318 Neutral MSH6 P52701 A194F 194 A F 0.424 Neutral MSH6 P52701 A194G 194 A G 0.126 Neutral MSH6 P52701 A194H 194 A H 0.314 Neutral MSH6 P52701 A194I 194 A I 0.418 Neutral MSH6 P52701 A194K 194 A K 0.256 Neutral MSH6 P52701 A194L 194 A L 0.36 Neutral MSH6 P52701 A194M 194 A M 0.3 Neutral MSH6 P52701 A194N 194 A N 0.322 Neutral MSH6 P52701 A194P 194 A P 0.038 Neutral MSH6 P52701 A194Q 194 A Q 0.312 Neutral MSH6 P52701 A194R 194 A R 0.378 Neutral MSH6 P52701 A194S 194 A S 0.104 Neutral MSH6 P52701 A194T 194 A T 0.184 Neutral MSH6 P52701 A194V 194 A V 0.046 Neutral MSH6 P52701 A194W 194 A W 0.514 Pathogenic MSH6 P52701 A194Y 194 A Y 0.512 Pathogenic MSH6 P52701 V195A 195 V A 0.068 Neutral MSH6 P52701 V195C 195 V C 0.104 Neutral MSH6 P52701 V195D 195 V D 0.194 Neutral MSH6 P52701 V195E 195 V E 0.13 Neutral MSH6 P52701 V195F 195 V F 0.346 Neutral MSH6 P52701 V195G 195 V G 0.266 Neutral MSH6 P52701 V195H 195 V H 0.22 Neutral MSH6 P52701 V195I 195 V I 0.006 Neutral MSH6 P52701 V195K 195 V K 0.284 Neutral MSH6 P52701 V195L 195 V L 0.002 Neutral MSH6 P52701 V195M 195 V M 0.168 Neutral MSH6 P52701 V195N 195 V N 0.21 Neutral MSH6 P52701 V195P 195 V P 0.32 Neutral MSH6 P52701 V195Q 195 V Q 0.34 Neutral MSH6 P52701 V195R 195 V R 0.468 Neutral MSH6 P52701 V195S 195 V S 0.104 Neutral MSH6 P52701 V195T 195 V T 0.072 Neutral MSH6 P52701 V195W 195 V W 0.518 Pathogenic MSH6 P52701 V195Y 195 V Y 0.438 Neutral MSH6 P52701 C196A 196 C A 0.064 Neutral MSH6 P52701 C196D 196 C D 0.036 Neutral MSH6 P52701 C196E 196 C E 0.038 Neutral MSH6 P52701 C196F 196 C F 0.56 Pathogenic MSH6 P52701 C196G 196 C G 0.178 Neutral MSH6 P52701 C196H 196 C H 0.296 Neutral MSH6 P52701 C196I 196 C I 0.332 Neutral MSH6 P52701 C196K 196 C K 0.236 Neutral MSH6 P52701 C196L 196 C L 0.358 Neutral MSH6 P52701 C196M 196 C M 0.188 Neutral MSH6 P52701 C196N 196 C N 0.004 Neutral MSH6 P52701 C196P 196 C P 0.33 Neutral MSH6 P52701 C196Q 196 C Q 0.168 Neutral MSH6 P52701 C196R 196 C R 0.406 Neutral MSH6 P52701 C196S 196 C S 0.19 Neutral MSH6 P52701 C196T 196 C T 0.158 Neutral MSH6 P52701 C196V 196 C V 0.048 Neutral MSH6 P52701 C196W 196 C W 0.636 Pathogenic MSH6 P52701 C196Y 196 C Y 0.602 Pathogenic MSH6 P52701 D197A 197 D A 0.1 Neutral MSH6 P52701 D197C 197 D C 0.148 Neutral MSH6 P52701 D197E 197 D E 0.12 Neutral MSH6 P52701 D197F 197 D F 0.406 Neutral MSH6 P52701 D197G 197 D G 0.14 Neutral MSH6 P52701 D197H 197 D H 0.154 Neutral MSH6 P52701 D197I 197 D I 0.302 Neutral MSH6 P52701 D197K 197 D K 0.052 Neutral MSH6 P52701 D197L 197 D L 0.026 Neutral MSH6 P52701 D197M 197 D M 0.036 Neutral MSH6 P52701 D197N 197 D N 0 Neutral MSH6 P52701 D197P 197 D P 0.288 Neutral MSH6 P52701 D197Q 197 D Q 0.032 Neutral MSH6 P52701 D197R 197 D R 0.128 Neutral MSH6 P52701 D197S 197 D S 0.002 Neutral MSH6 P52701 D197T 197 D T 0.012 Neutral MSH6 P52701 D197V 197 D V 0.07 Neutral MSH6 P52701 D197W 197 D W 0.434 Neutral MSH6 P52701 D197Y 197 D Y 0.404 Neutral MSH6 P52701 E198A 198 E A 0.144 Neutral MSH6 P52701 E198C 198 E C 0.068 Neutral MSH6 P52701 E198D 198 E D 0 Neutral MSH6 P52701 E198F 198 E F 0.272 Neutral MSH6 P52701 E198G 198 E G 0.054 Neutral MSH6 P52701 E198H 198 E H 0.104 Neutral MSH6 P52701 E198I 198 E I 0.322 Neutral MSH6 P52701 E198K 198 E K 0.068 Neutral MSH6 P52701 E198L 198 E L 0.042 Neutral MSH6 P52701 E198M 198 E M 0.164 Neutral MSH6 P52701 E198N 198 E N 0.002 Neutral MSH6 P52701 E198P 198 E P 0.3 Neutral MSH6 P52701 E198Q 198 E Q 0 Neutral MSH6 P52701 E198R 198 E R 0.03 Neutral MSH6 P52701 E198S 198 E S 0.168 Neutral MSH6 P52701 E198T 198 E T 0.14 Neutral MSH6 P52701 E198V 198 E V 0.066 Neutral MSH6 P52701 E198W 198 E W 0.43 Neutral MSH6 P52701 E198Y 198 E Y 0.338 Neutral MSH6 P52701 P199A 199 P A 0.138 Neutral MSH6 P52701 P199C 199 P C 0.234 Neutral MSH6 P52701 P199D 199 P D 0.092 Neutral MSH6 P52701 P199E 199 P E 0.364 Neutral MSH6 P52701 P199F 199 P F 0.464 Neutral MSH6 P52701 P199G 199 P G 0.136 Neutral MSH6 P52701 P199H 199 P H 0.478 Neutral MSH6 P52701 P199I 199 P I 0.21 Neutral MSH6 P52701 P199K 199 P K 0.29 Neutral MSH6 P52701 P199L 199 P L 0.126 Neutral MSH6 P52701 P199M 199 P M 0.382 Neutral MSH6 P52701 P199N 199 P N 0.108 Neutral MSH6 P52701 P199Q 199 P Q 0.162 Neutral MSH6 P52701 P199R 199 P R 0.528 Pathogenic MSH6 P52701 P199S 199 P S 0.248 Neutral MSH6 P52701 P199T 199 P T 0.254 Neutral MSH6 P52701 P199V 199 P V 0.156 Neutral MSH6 P52701 P199W 199 P W 0.606 Pathogenic MSH6 P52701 P199Y 199 P Y 0.54 Pathogenic MSH6 P52701 S2A 2 S A 0.012 Neutral MSH6 P52701 S2C 2 S C 0.032 Neutral MSH6 P52701 S2D 2 S D 0.044 Neutral MSH6 P52701 S2E 2 S E 0.148 Neutral MSH6 P52701 S2F 2 S F 0.276 Neutral MSH6 P52701 S2G 2 S G 0.064 Neutral MSH6 P52701 S2H 2 S H 0.238 Neutral MSH6 P52701 S2I 2 S I 0.026 Neutral MSH6 P52701 S2K 2 S K 0.164 Neutral MSH6 P52701 S2L 2 S L 0.028 Neutral MSH6 P52701 S2M 2 S M 0.332 Neutral MSH6 P52701 S2N 2 S N 0.034 Neutral MSH6 P52701 S2P 2 S P 0.116 Neutral MSH6 P52701 S2Q 2 S Q 0.158 Neutral MSH6 P52701 S2R 2 S R 0.248 Neutral MSH6 P52701 S2T 2 S T 0.11 Neutral MSH6 P52701 S2V 2 S V 0.248 Neutral MSH6 P52701 S2W 2 S W 0.49 Neutral MSH6 P52701 S2Y 2 S Y 0.448 Neutral MSH6 P52701 A20C 20 A C 0.182 Neutral MSH6 P52701 A20D 20 A D 0.266 Neutral MSH6 P52701 A20E 20 A E 0.306 Neutral MSH6 P52701 A20F 20 A F 0.468 Neutral MSH6 P52701 A20G 20 A G 0.154 Neutral MSH6 P52701 A20H 20 A H 0.304 Neutral MSH6 P52701 A20I 20 A I 0.406 Neutral MSH6 P52701 A20K 20 A K 0.27 Neutral MSH6 P52701 A20L 20 A L 0.4 Neutral MSH6 P52701 A20M 20 A M 0.29 Neutral MSH6 P52701 A20N 20 A N 0.314 Neutral MSH6 P52701 A20P 20 A P 0.076 Neutral MSH6 P52701 A20Q 20 A Q 0.302 Neutral MSH6 P52701 A20R 20 A R 0.318 Neutral MSH6 P52701 A20S 20 A S 0.102 Neutral MSH6 P52701 A20T 20 A T 0.08 Neutral MSH6 P52701 A20V 20 A V 0.202 Neutral MSH6 P52701 A20W 20 A W 0.504 Pathogenic MSH6 P52701 A20Y 20 A Y 0.5 Pathogenic MSH6 P52701 S200A 200 S A 0.142 Neutral MSH6 P52701 S200C 200 S C 0.074 Neutral MSH6 P52701 S200D 200 S D 0.05 Neutral MSH6 P52701 S200E 200 S E 0.278 Neutral MSH6 P52701 S200F 200 S F 0.518 Pathogenic MSH6 P52701 S200G 200 S G 0.118 Neutral MSH6 P52701 S200H 200 S H 0.444 Neutral MSH6 P52701 S200I 200 S I 0.168 Neutral MSH6 P52701 S200K 200 S K 0.326 Neutral MSH6 P52701 S200L 200 S L 0.114 Neutral MSH6 P52701 S200M 200 S M 0.626 Pathogenic MSH6 P52701 S200N 200 S N 0.098 Neutral MSH6 P52701 S200P 200 S P 0.216 Neutral MSH6 P52701 S200Q 200 S Q 0.318 Neutral MSH6 P52701 S200R 200 S R 0.444 Neutral MSH6 P52701 S200T 200 S T 0.18 Neutral MSH6 P52701 S200V 200 S V 0.404 Neutral MSH6 P52701 S200W 200 S W 0.74 Pathogenic MSH6 P52701 S200Y 200 S Y 0.678 Pathogenic MSH6 P52701 E201A 201 E A 0.122 Neutral MSH6 P52701 E201C 201 E C 0.068 Neutral MSH6 P52701 E201D 201 E D 0 Neutral MSH6 P52701 E201F 201 E F 0.296 Neutral MSH6 P52701 E201G 201 E G 0.054 Neutral MSH6 P52701 E201H 201 E H 0.108 Neutral MSH6 P52701 E201I 201 E I 0.352 Neutral MSH6 P52701 E201K 201 E K 0.168 Neutral MSH6 P52701 E201L 201 E L 0.308 Neutral MSH6 P52701 E201M 201 E M 0.176 Neutral MSH6 P52701 E201N 201 E N 0.056 Neutral MSH6 P52701 E201P 201 E P 0.134 Neutral MSH6 P52701 E201Q 201 E Q 0.056 Neutral MSH6 P52701 E201R 201 E R 0.048 Neutral MSH6 P52701 E201S 201 E S 0.014 Neutral MSH6 P52701 E201T 201 E T 0.082 Neutral MSH6 P52701 E201V 201 E V 0.272 Neutral MSH6 P52701 E201W 201 E W 0.494 Neutral MSH6 P52701 E201Y 201 E Y 0.388 Neutral MSH6 P52701 P202A 202 P A 0.176 Neutral MSH6 P52701 P202C 202 P C 0.148 Neutral MSH6 P52701 P202D 202 P D 0.008 Neutral MSH6 P52701 P202E 202 P E 0.052 Neutral MSH6 P52701 P202F 202 P F 0.272 Neutral MSH6 P52701 P202G 202 P G 0.092 Neutral MSH6 P52701 P202H 202 P H 0.266 Neutral MSH6 P52701 P202I 202 P I 0.1 Neutral MSH6 P52701 P202K 202 P K 0.1 Neutral MSH6 P52701 P202L 202 P L 0.094 Neutral MSH6 P52701 P202M 202 P M 0.22 Neutral MSH6 P52701 P202N 202 P N 0.068 Neutral MSH6 P52701 P202Q 202 P Q 0.212 Neutral MSH6 P52701 P202R 202 P R 0.202 Neutral MSH6 P52701 P202S 202 P S 0.022 Neutral MSH6 P52701 P202T 202 P T 0.122 Neutral MSH6 P52701 P202V 202 P V 0.184 Neutral MSH6 P52701 P202W 202 P W 0.39 Neutral MSH6 P52701 P202Y 202 P Y 0.32 Neutral MSH6 P52701 E203A 203 E A 0.144 Neutral MSH6 P52701 E203C 203 E C 0.068 Neutral MSH6 P52701 E203D 203 E D 0.004 Neutral MSH6 P52701 E203F 203 E F 0.272 Neutral MSH6 P52701 E203G 203 E G 0.054 Neutral MSH6 P52701 E203H 203 E H 0.104 Neutral MSH6 P52701 E203I 203 E I 0.284 Neutral MSH6 P52701 E203K 203 E K 0.026 Neutral MSH6 P52701 E203L 203 E L 0.286 Neutral MSH6 P52701 E203M 203 E M 0.164 Neutral MSH6 P52701 E203N 203 E N 0.056 Neutral MSH6 P52701 E203P 203 E P 0.046 Neutral MSH6 P52701 E203Q 203 E Q 0.056 Neutral MSH6 P52701 E203R 203 E R 0.046 Neutral MSH6 P52701 E203S 203 E S 0.168 Neutral MSH6 P52701 E203T 203 E T 0.14 Neutral MSH6 P52701 E203V 203 E V 0.25 Neutral MSH6 P52701 E203W 203 E W 0.43 Neutral MSH6 P52701 E203Y 203 E Y 0.398 Neutral MSH6 P52701 E204A 204 E A 0.212 Neutral MSH6 P52701 E204C 204 E C 0.068 Neutral MSH6 P52701 E204D 204 E D 0 Neutral MSH6 P52701 E204F 204 E F 0.272 Neutral MSH6 P52701 E204G 204 E G 0.054 Neutral MSH6 P52701 E204H 204 E H 0.104 Neutral MSH6 P52701 E204I 204 E I 0.284 Neutral MSH6 P52701 E204K 204 E K 0.162 Neutral MSH6 P52701 E204L 204 E L 0.286 Neutral MSH6 P52701 E204M 204 E M 0.164 Neutral MSH6 P52701 E204N 204 E N 0.036 Neutral MSH6 P52701 E204P 204 E P 0.3 Neutral MSH6 P52701 E204Q 204 E Q 0.056 Neutral MSH6 P52701 E204R 204 E R 0.016 Neutral MSH6 P52701 E204S 204 E S 0.014 Neutral MSH6 P52701 E204T 204 E T 0.006 Neutral MSH6 P52701 E204V 204 E V 0.232 Neutral MSH6 P52701 E204W 204 E W 0.43 Neutral MSH6 P52701 E204Y 204 E Y 0.338 Neutral MSH6 P52701 E205A 205 E A 0.178 Neutral MSH6 P52701 E205C 205 E C 0.124 Neutral MSH6 P52701 E205D 205 E D 0.006 Neutral MSH6 P52701 E205F 205 E F 0.43 Neutral MSH6 P52701 E205G 205 E G 0.114 Neutral MSH6 P52701 E205H 205 E H 0.176 Neutral MSH6 P52701 E205I 205 E I 0.45 Neutral MSH6 P52701 E205K 205 E K 0.282 Neutral MSH6 P52701 E205L 205 E L 0.45 Neutral MSH6 P52701 E205M 205 E M 0.288 Neutral MSH6 P52701 E205N 205 E N 0.092 Neutral MSH6 P52701 E205P 205 E P 0.436 Neutral MSH6 P52701 E205Q 205 E Q 0.09 Neutral MSH6 P52701 E205R 205 E R 0.124 Neutral MSH6 P52701 E205S 205 E S 0.028 Neutral MSH6 P52701 E205T 205 E T 0.222 Neutral MSH6 P52701 E205V 205 E V 0.368 Neutral MSH6 P52701 E205W 205 E W 0.702 Pathogenic MSH6 P52701 E205Y 205 E Y 0.586 Pathogenic MSH6 P52701 E206A 206 E A 0.244 Neutral MSH6 P52701 E206C 206 E C 0.122 Neutral MSH6 P52701 E206D 206 E D 0.006 Neutral MSH6 P52701 E206F 206 E F 0.422 Neutral MSH6 P52701 E206G 206 E G 0.084 Neutral MSH6 P52701 E206H 206 E H 0.174 Neutral MSH6 P52701 E206I 206 E I 0.442 Neutral MSH6 P52701 E206K 206 E K 0.274 Neutral MSH6 P52701 E206L 206 E L 0.444 Neutral MSH6 P52701 E206M 206 E M 0.282 Neutral MSH6 P52701 E206N 206 E N 0.092 Neutral MSH6 P52701 E206P 206 E P 0.454 Neutral MSH6 P52701 E206Q 206 E Q 0.03 Neutral MSH6 P52701 E206R 206 E R 0.122 Neutral MSH6 P52701 E206S 206 E S 0.226 Neutral MSH6 P52701 E206T 206 E T 0.214 Neutral MSH6 P52701 E206V 206 E V 0.39 Neutral MSH6 P52701 E206W 206 E W 0.694 Pathogenic MSH6 P52701 E206Y 206 E Y 0.424 Neutral MSH6 P52701 E207A 207 E A 0.144 Neutral MSH6 P52701 E207C 207 E C 0.068 Neutral MSH6 P52701 E207D 207 E D 0 Neutral MSH6 P52701 E207F 207 E F 0.282 Neutral MSH6 P52701 E207G 207 E G 0.024 Neutral MSH6 P52701 E207H 207 E H 0.106 Neutral MSH6 P52701 E207I 207 E I 0.334 Neutral MSH6 P52701 E207K 207 E K 0.164 Neutral MSH6 P52701 E207L 207 E L 0.296 Neutral MSH6 P52701 E207M 207 E M 0.176 Neutral MSH6 P52701 E207N 207 E N 0.036 Neutral MSH6 P52701 E207P 207 E P 0.308 Neutral MSH6 P52701 E207Q 207 E Q 0 Neutral MSH6 P52701 E207R 207 E R 0.046 Neutral MSH6 P52701 E207S 207 E S 0.17 Neutral MSH6 P52701 E207T 207 E T 0.144 Neutral MSH6 P52701 E207V 207 E V 0.258 Neutral MSH6 P52701 E207W 207 E W 0.448 Neutral MSH6 P52701 E207Y 207 E Y 0.358 Neutral MSH6 P52701 M208A 208 M A 0.084 Neutral MSH6 P52701 M208C 208 M C 0.032 Neutral MSH6 P52701 M208D 208 M D 0.074 Neutral MSH6 P52701 M208E 208 M E 0.008 Neutral MSH6 P52701 M208F 208 M F 0.218 Neutral MSH6 P52701 M208G 208 M G 0.118 Neutral MSH6 P52701 M208H 208 M H 0.058 Neutral MSH6 P52701 M208I 208 M I 0.09 Neutral MSH6 P52701 M208K 208 M K 0.082 Neutral MSH6 P52701 M208L 208 M L 0.062 Neutral MSH6 P52701 M208N 208 M N 0.186 Neutral MSH6 P52701 M208P 208 M P 0.262 Neutral MSH6 P52701 M208Q 208 M Q 0.068 Neutral MSH6 P52701 M208R 208 M R 0.164 Neutral MSH6 P52701 M208S 208 M S 0.16 Neutral MSH6 P52701 M208T 208 M T 0.008 Neutral MSH6 P52701 M208V 208 M V 0.068 Neutral MSH6 P52701 M208W 208 M W 0.422 Neutral MSH6 P52701 M208Y 208 M Y 0.348 Neutral MSH6 P52701 E209A 209 E A 0.122 Neutral MSH6 P52701 E209C 209 E C 0.068 Neutral MSH6 P52701 E209D 209 E D 0 Neutral MSH6 P52701 E209F 209 E F 0.29 Neutral MSH6 P52701 E209G 209 E G 0.054 Neutral MSH6 P52701 E209H 209 E H 0.106 Neutral MSH6 P52701 E209I 209 E I 0.306 Neutral MSH6 P52701 E209K 209 E K 0.164 Neutral MSH6 P52701 E209L 209 E L 0.308 Neutral MSH6 P52701 E209M 209 E M 0.176 Neutral MSH6 P52701 E209N 209 E N 0.056 Neutral MSH6 P52701 E209P 209 E P 0.318 Neutral MSH6 P52701 E209Q 209 E Q 0.056 Neutral MSH6 P52701 E209R 209 E R 0.048 Neutral MSH6 P52701 E209S 209 E S 0.17 Neutral MSH6 P52701 E209T 209 E T 0.144 Neutral MSH6 P52701 E209V 209 E V 0.072 Neutral MSH6 P52701 E209W 209 E W 0.488 Neutral MSH6 P52701 E209Y 209 E Y 0.382 Neutral MSH6 P52701 N21A 21 N A 0.004 Neutral MSH6 P52701 N21C 21 N C 0.148 Neutral MSH6 P52701 N21D 21 N D 0.118 Neutral MSH6 P52701 N21E 21 N E 0.096 Neutral MSH6 P52701 N21F 21 N F 0.34 Neutral MSH6 P52701 N21G 21 N G 0.16 Neutral MSH6 P52701 N21H 21 N H 0.23 Neutral MSH6 P52701 N21I 21 N I 0.264 Neutral MSH6 P52701 N21K 21 N K 0.148 Neutral MSH6 P52701 N21L 21 N L 0.314 Neutral MSH6 P52701 N21M 21 N M 0.22 Neutral MSH6 P52701 N21P 21 N P 0.158 Neutral MSH6 P52701 N21Q 21 N Q 0.166 Neutral MSH6 P52701 N21R 21 N R 0.158 Neutral MSH6 P52701 N21S 21 N S 0 Neutral MSH6 P52701 N21T 21 N T 0.116 Neutral MSH6 P52701 N21V 21 N V 0.262 Neutral MSH6 P52701 N21W 21 N W 0.446 Neutral MSH6 P52701 N21Y 21 N Y 0.402 Neutral MSH6 P52701 V210A 210 V A 0.01 Neutral MSH6 P52701 V210C 210 V C 0.058 Neutral MSH6 P52701 V210D 210 V D 0.034 Neutral MSH6 P52701 V210E 210 V E 0.044 Neutral MSH6 P52701 V210F 210 V F 0.172 Neutral MSH6 P52701 V210G 210 V G 0.178 Neutral MSH6 P52701 V210H 210 V H 0.112 Neutral MSH6 P52701 V210I 210 V I 0.038 Neutral MSH6 P52701 V210K 210 V K 0.158 Neutral MSH6 P52701 V210L 210 V L 0.004 Neutral MSH6 P52701 V210M 210 V M 0.014 Neutral MSH6 P52701 V210N 210 V N 0.138 Neutral MSH6 P52701 V210P 210 V P 0.142 Neutral MSH6 P52701 V210Q 210 V Q 0.216 Neutral MSH6 P52701 V210R 210 V R 0.274 Neutral MSH6 P52701 V210S 210 V S 0.09 Neutral MSH6 P52701 V210T 210 V T 0.094 Neutral MSH6 P52701 V210W 210 V W 0.344 Neutral MSH6 P52701 V210Y 210 V Y 0.256 Neutral MSH6 P52701 G211A 211 G A 0.002 Neutral MSH6 P52701 G211C 211 G C 0.132 Neutral MSH6 P52701 G211D 211 G D 0.118 Neutral MSH6 P52701 G211E 211 G E 0.19 Neutral MSH6 P52701 G211F 211 G F 0.498 Neutral MSH6 P52701 G211H 211 G H 0.37 Neutral MSH6 P52701 G211I 211 G I 0.412 Neutral MSH6 P52701 G211K 211 G K 0.358 Neutral MSH6 P52701 G211L 211 G L 0.412 Neutral MSH6 P52701 G211M 211 G M 0.422 Neutral MSH6 P52701 G211N 211 G N 0.252 Neutral MSH6 P52701 G211P 211 G P 0.372 Neutral MSH6 P52701 G211Q 211 G Q 0.262 Neutral MSH6 P52701 G211R 211 G R 0.362 Neutral MSH6 P52701 G211S 211 G S 0.186 Neutral MSH6 P52701 G211T 211 G T 0.274 Neutral MSH6 P52701 G211V 211 G V 0.318 Neutral MSH6 P52701 G211W 211 G W 0.498 Neutral MSH6 P52701 G211Y 211 G Y 0.482 Neutral MSH6 P52701 T212A 212 T A 0 Neutral MSH6 P52701 T212C 212 T C 0.064 Neutral MSH6 P52701 T212D 212 T D 0.046 Neutral MSH6 P52701 T212E 212 T E 0.024 Neutral MSH6 P52701 T212F 212 T F 0.214 Neutral MSH6 P52701 T212G 212 T G 0.036 Neutral MSH6 P52701 T212H 212 T H 0.084 Neutral MSH6 P52701 T212I 212 T I 0.066 Neutral MSH6 P52701 T212K 212 T K 0.026 Neutral MSH6 P52701 T212L 212 T L 0.074 Neutral MSH6 P52701 T212M 212 T M 0.032 Neutral MSH6 P52701 T212N 212 T N 0.02 Neutral MSH6 P52701 T212P 212 T P 0.02 Neutral MSH6 P52701 T212Q 212 T Q 0.016 Neutral MSH6 P52701 T212R 212 T R 0.26 Neutral MSH6 P52701 T212S 212 T S 0.054 Neutral MSH6 P52701 T212V 212 T V 0.046 Neutral MSH6 P52701 T212W 212 T W 0.466 Neutral MSH6 P52701 T212Y 212 T Y 0.424 Neutral MSH6 P52701 T213A 213 T A 0 Neutral MSH6 P52701 T213C 213 T C 0.064 Neutral MSH6 P52701 T213D 213 T D 0.046 Neutral MSH6 P52701 T213E 213 T E 0.024 Neutral MSH6 P52701 T213F 213 T F 0.214 Neutral MSH6 P52701 T213G 213 T G 0.036 Neutral MSH6 P52701 T213H 213 T H 0.056 Neutral MSH6 P52701 T213I 213 T I 0.066 Neutral MSH6 P52701 T213K 213 T K 0.032 Neutral MSH6 P52701 T213L 213 T L 0.074 Neutral MSH6 P52701 T213M 213 T M 0.048 Neutral MSH6 P52701 T213N 213 T N 0.002 Neutral MSH6 P52701 T213P 213 T P 0.084 Neutral MSH6 P52701 T213Q 213 T Q 0.052 Neutral MSH6 P52701 T213R 213 T R 0.26 Neutral MSH6 P52701 T213S 213 T S 0.024 Neutral MSH6 P52701 T213V 213 T V 0.046 Neutral MSH6 P52701 T213W 213 T W 0.466 Neutral MSH6 P52701 T213Y 213 T Y 0.424 Neutral MSH6 P52701 Y214A 214 Y A 0.082 Neutral MSH6 P52701 Y214C 214 Y C 0.112 Neutral MSH6 P52701 Y214D 214 Y D 0.034 Neutral MSH6 P52701 Y214E 214 Y E 0.032 Neutral MSH6 P52701 Y214F 214 Y F 0.058 Neutral MSH6 P52701 Y214G 214 Y G 0.122 Neutral MSH6 P52701 Y214H 214 Y H 0.058 Neutral MSH6 P52701 Y214I 214 Y I 0.038 Neutral MSH6 P52701 Y214K 214 Y K 0.096 Neutral MSH6 P52701 Y214L 214 Y L 0.044 Neutral MSH6 P52701 Y214M 214 Y M 0.008 Neutral MSH6 P52701 Y214N 214 Y N 0.072 Neutral MSH6 P52701 Y214P 214 Y P 0.064 Neutral MSH6 P52701 Y214Q 214 Y Q 0.122 Neutral MSH6 P52701 Y214R 214 Y R 0.156 Neutral MSH6 P52701 Y214S 214 Y S 0.096 Neutral MSH6 P52701 Y214T 214 Y T 0.112 Neutral MSH6 P52701 Y214V 214 Y V 0.162 Neutral MSH6 P52701 Y214W 214 Y W 0.048 Neutral MSH6 P52701 V215A 215 V A 0 Neutral MSH6 P52701 V215C 215 V C 0.058 Neutral MSH6 P52701 V215D 215 V D 0.026 Neutral MSH6 P52701 V215E 215 V E 0.044 Neutral MSH6 P52701 V215F 215 V F 0.15 Neutral MSH6 P52701 V215G 215 V G 0.054 Neutral MSH6 P52701 V215H 215 V H 0.112 Neutral MSH6 P52701 V215I 215 V I 0.038 Neutral MSH6 P52701 V215K 215 V K 0.158 Neutral MSH6 P52701 V215L 215 V L 0.018 Neutral MSH6 P52701 V215M 215 V M 0.014 Neutral MSH6 P52701 V215N 215 V N 0.138 Neutral MSH6 P52701 V215P 215 V P 0.19 Neutral MSH6 P52701 V215Q 215 V Q 0.158 Neutral MSH6 P52701 V215R 215 V R 0.274 Neutral MSH6 P52701 V215S 215 V S 0.01 Neutral MSH6 P52701 V215T 215 V T 0.008 Neutral MSH6 P52701 V215W 215 V W 0.344 Neutral MSH6 P52701 V215Y 215 V Y 0.256 Neutral MSH6 P52701 T216A 216 T A 0.078 Neutral MSH6 P52701 T216C 216 T C 0.064 Neutral MSH6 P52701 T216D 216 T D 0.022 Neutral MSH6 P52701 T216E 216 T E 0.024 Neutral MSH6 P52701 T216F 216 T F 0.214 Neutral MSH6 P52701 T216G 216 T G 0.036 Neutral MSH6 P52701 T216H 216 T H 0.084 Neutral MSH6 P52701 T216I 216 T I 0.048 Neutral MSH6 P52701 T216K 216 T K 0.042 Neutral MSH6 P52701 T216L 216 T L 0.008 Neutral MSH6 P52701 T216M 216 T M 0.098 Neutral MSH6 P52701 T216N 216 T N 0.02 Neutral MSH6 P52701 T216P 216 T P 0.084 Neutral MSH6 P52701 T216Q 216 T Q 0.01 Neutral MSH6 P52701 T216R 216 T R 0.26 Neutral MSH6 P52701 T216S 216 T S 0 Neutral MSH6 P52701 T216V 216 T V 0.02 Neutral MSH6 P52701 T216W 216 T W 0.466 Neutral MSH6 P52701 T216Y 216 T Y 0.374 Neutral MSH6 P52701 D217A 217 D A 0.1 Neutral MSH6 P52701 D217C 217 D C 0.148 Neutral MSH6 P52701 D217E 217 D E 0.014 Neutral MSH6 P52701 D217F 217 D F 0.37 Neutral MSH6 P52701 D217G 217 D G 0.036 Neutral MSH6 P52701 D217H 217 D H 0.09 Neutral MSH6 P52701 D217I 217 D I 0.262 Neutral MSH6 P52701 D217K 217 D K 0.112 Neutral MSH6 P52701 D217L 217 D L 0.028 Neutral MSH6 P52701 D217M 217 D M 0.19 Neutral MSH6 P52701 D217N 217 D N 0.02 Neutral MSH6 P52701 D217P 217 D P 0.31 Neutral MSH6 P52701 D217Q 217 D Q 0.078 Neutral MSH6 P52701 D217R 217 D R 0.152 Neutral MSH6 P52701 D217S 217 D S 0.196 Neutral MSH6 P52701 D217T 217 D T 0.116 Neutral MSH6 P52701 D217V 217 D V 0.262 Neutral MSH6 P52701 D217W 217 D W 0.434 Neutral MSH6 P52701 D217Y 217 D Y 0.432 Neutral MSH6 P52701 K218A 218 K A 0.096 Neutral MSH6 P52701 K218C 218 K C 0.028 Neutral MSH6 P52701 K218D 218 K D 0.05 Neutral MSH6 P52701 K218E 218 K E 0.004 Neutral MSH6 P52701 K218F 218 K F 0.212 Neutral MSH6 P52701 K218G 218 K G 0.132 Neutral MSH6 P52701 K218H 218 K H 0.048 Neutral MSH6 P52701 K218I 218 K I 0.222 Neutral MSH6 P52701 K218L 218 K L 0.214 Neutral MSH6 P52701 K218M 218 K M 0.106 Neutral MSH6 P52701 K218N 218 K N 0.006 Neutral MSH6 P52701 K218P 218 K P 0.214 Neutral MSH6 P52701 K218Q 218 K Q 0.048 Neutral MSH6 P52701 K218R 218 K R 0.056 Neutral MSH6 P52701 K218S 218 K S 0.012 Neutral MSH6 P52701 K218T 218 K T 0.092 Neutral MSH6 P52701 K218V 218 K V 0.054 Neutral MSH6 P52701 K218W 218 K W 0.396 Neutral MSH6 P52701 K218Y 218 K Y 0.226 Neutral MSH6 P52701 S219A 219 S A 0.01 Neutral MSH6 P52701 S219C 219 S C 0.022 Neutral MSH6 P52701 S219D 219 S D 0.024 Neutral MSH6 P52701 S219E 219 S E 0.14 Neutral MSH6 P52701 S219F 219 S F 0.276 Neutral MSH6 P52701 S219G 219 S G 0 Neutral MSH6 P52701 S219H 219 S H 0.188 Neutral MSH6 P52701 S219I 219 S I 0.026 Neutral MSH6 P52701 S219K 219 S K 0.164 Neutral MSH6 P52701 S219L 219 S L 0.042 Neutral MSH6 P52701 S219M 219 S M 0.252 Neutral MSH6 P52701 S219N 219 S N 0.004 Neutral MSH6 P52701 S219P 219 S P 0.116 Neutral MSH6 P52701 S219Q 219 S Q 0.132 Neutral MSH6 P52701 S219R 219 S R 0.152 Neutral MSH6 P52701 S219T 219 S T 0.176 Neutral MSH6 P52701 S219V 219 S V 0.134 Neutral MSH6 P52701 S219W 219 S W 0.472 Neutral MSH6 P52701 S219Y 219 S Y 0.434 Neutral MSH6 P52701 K22A 22 K A 0.054 Neutral MSH6 P52701 K22C 22 K C 0.028 Neutral MSH6 P52701 K22D 22 K D 0.066 Neutral MSH6 P52701 K22E 22 K E 0.072 Neutral MSH6 P52701 K22F 22 K F 0.212 Neutral MSH6 P52701 K22G 22 K G 0.13 Neutral MSH6 P52701 K22H 22 K H 0.048 Neutral MSH6 P52701 K22I 22 K I 0.222 Neutral MSH6 P52701 K22L 22 K L 0.214 Neutral MSH6 P52701 K22M 22 K M 0.106 Neutral MSH6 P52701 K22N 22 K N 0.082 Neutral MSH6 P52701 K22P 22 K P 0.236 Neutral MSH6 P52701 K22Q 22 K Q 0.048 Neutral MSH6 P52701 K22R 22 K R 0.056 Neutral MSH6 P52701 K22S 22 K S 0.014 Neutral MSH6 P52701 K22T 22 K T 0.09 Neutral MSH6 P52701 K22V 22 K V 0.18 Neutral MSH6 P52701 K22W 22 K W 0.396 Neutral MSH6 P52701 K22Y 22 K Y 0.326 Neutral MSH6 P52701 E220A 220 E A 0.122 Neutral MSH6 P52701 E220C 220 E C 0.068 Neutral MSH6 P52701 E220D 220 E D 0 Neutral 2 MSH6 P52701 E220F 220 E F 0.272 Neutral MSH6 P52701 E220G 220 E G 0 Neutral MSH6 P52701 E220H 220 E H 0.104 Neutral MSH6 P52701 E220I 220 E I 0.284 Neutral MSH6 P52701 E220K 220 E K 0.002 Neutral MSH6 P52701 E220L 220 E L 0.286 Neutral MSH6 P52701 E220M 220 E M 0.164 Neutral MSH6 P52701 E220N 220 E N 0.04 Neutral MSH6 P52701 E220P 220 E P 0.3 Neutral MSH6 P52701 E220Q 220 E Q 0.018 Neutral MSH6 P52701 E220R 220 E R 0.046 Neutral MSH6 P52701 E220S 220 E S 0.014 Neutral MSH6 P52701 E220T 220 E T 0.008 Neutral MSH6 P52701 E220V 220 E V 0.066 Neutral MSH6 P52701 E220W 220 E W 0.43 Neutral MSH6 P52701 E220Y 220 E Y 0.296 Neutral MSH6 P52701 E221A 221 E A 0.144 Neutral MSH6 P52701 E221C 221 E C 0.068 Neutral MSH6 P52701 E221D 221 E D 0.004 Neutral MSH6 P52701 E221F 221 E F 0.272 Neutral MSH6 P52701 E221G 221 E G 0 Neutral MSH6 P52701 E221H 221 E H 0.104 Neutral MSH6 P52701 E221I 221 E I 0.128 Neutral MSH6 P52701 E221K 221 E K 0.144 Neutral MSH6 P52701 E221L 221 E L 0.042 Neutral MSH6 P52701 E221M 221 E M 0.164 Neutral MSH6 P52701 E221N 221 E N 0.056 Neutral MSH6 P52701 E221P 221 E P 0.282 Neutral MSH6 P52701 E221Q 221 E Q 0.018 Neutral MSH6 P52701 E221R 221 E R 0.036 Neutral MSH6 P52701 E221S 221 E S 0.014 Neutral MSH6 P52701 E221T 221 E T 0.02 Neutral MSH6 P52701 E221V 221 E V 0.034 Neutral MSH6 P52701 E221W 221 E W 0.43 Neutral MSH6 P52701 E221Y 221 E Y 0.338 Neutral MSH6 P52701 D222A 222 D A 0.072 Neutral MSH6 P52701 D222C 222 D C 0.17 Neutral MSH6 P52701 D222E 222 D E 0.014 Neutral MSH6 P52701 D222F 222 D F 0.37 Neutral MSH6 P52701 D222G 222 D G 0.036 Neutral MSH6 P52701 D222H 222 D H 0.09 Neutral MSH6 P52701 D222I 222 D I 0.302 Neutral MSH6 P52701 D222K 222 D K 0.21 Neutral MSH6 P52701 D222L 222 D L 0.262 Neutral MSH6 P52701 D222M 222 D M 0.19 Neutral MSH6 P52701 D222N 222 D N 0 Neutral MSH6 P52701 D222P 222 D P 0.144 Neutral MSH6 P52701 D222Q 222 D Q 0.032 Neutral MSH6 P52701 D222R 222 D R 0.128 Neutral MSH6 P52701 D222S 222 D S 0.002 Neutral MSH6 P52701 D222T 222 D T 0.012 Neutral MSH6 P52701 D222V 222 D V 0.262 Neutral MSH6 P52701 D222W 222 D W 0.434 Neutral MSH6 P52701 D222Y 222 D Y 0.404 Neutral MSH6 P52701 N223A 223 N A 0.092 Neutral MSH6 P52701 N223C 223 N C 0.148 Neutral MSH6 P52701 N223D 223 N D 0.008 Neutral MSH6 P52701 N223E 223 N E 0.02 Neutral MSH6 P52701 N223F 223 N F 0.34 Neutral MSH6 P52701 N223G 223 N G 0.162 Neutral MSH6 P52701 N223H 223 N H 0.024 Neutral MSH6 P52701 N223I 223 N I 0.336 Neutral MSH6 P52701 N223K 223 N K 0.038 Neutral MSH6 P52701 N223L 223 N L 0.272 Neutral MSH6 P52701 N223M 223 N M 0.22 Neutral MSH6 P52701 N223P 223 N P 0.338 Neutral MSH6 P52701 N223Q 223 N Q 0.114 Neutral MSH6 P52701 N223R 223 N R 0.136 Neutral MSH6 P52701 N223S 223 N S 0.146 Neutral MSH6 P52701 N223T 223 N T 0.142 Neutral MSH6 P52701 N223V 223 N V 0.12 Neutral MSH6 P52701 N223W 223 N W 0.446 Neutral MSH6 P52701 N223Y 223 N Y 0.45 Neutral MSH6 P52701 E224A 224 E A 0.212 Neutral MSH6 P52701 E224C 224 E C 0.068 Neutral MSH6 P52701 E224D 224 E D 0 Neutral MSH6 P52701 E224F 224 E F 0.272 Neutral MSH6 P52701 E224G 224 E G 0.024 Neutral MSH6 P52701 E224H 224 E H 0.104 Neutral MSH6 P52701 E224I 224 E I 0.322 Neutral MSH6 P52701 E224K 224 E K 0.002 Neutral MSH6 P52701 E224L 224 E L 0.286 Neutral MSH6 P52701 E224M 224 E M 0.164 Neutral MSH6 P52701 E224N 224 E N 0.04 Neutral MSH6 P52701 E224P 224 E P 0.124 Neutral MSH6 P52701 E224Q 224 E Q 0.056 Neutral MSH6 P52701 E224R 224 E R 0.03 Neutral MSH6 P52701 E224S 224 E S 0.014 Neutral MSH6 P52701 E224T 224 E T 0.02 Neutral MSH6 P52701 E224V 224 E V 0.232 Neutral MSH6 P52701 E224W 224 E W 0.43 Neutral MSH6 P52701 E224Y 224 E Y 0.398 Neutral MSH6 P52701 I225A 225 I A 0.072 Neutral MSH6 P52701 I225C 225 I C 0.09 Neutral MSH6 P52701 I225D 225 I D 0.166 Neutral MSH6 P52701 I225E 225 I E 0.03 Neutral MSH6 P52701 I225F 225 I F 0.206 Neutral MSH6 P52701 I225G 225 I G 0.192 Neutral MSH6 P52701 I225H 225 I H 0.08 Neutral MSH6 P52701 I225K 225 I K 0.042 Neutral MSH6 P52701 I225L 225 I L 0.15 Neutral MSH6 P52701 I225M 225 I M 0.166 Neutral MSH6 P52701 I225N 225 I N 0.096 Neutral MSH6 P52701 I225P 225 I P 0.186 Neutral MSH6 P52701 I225Q 225 I Q 0.096 Neutral MSH6 P52701 I225R 225 I R 0.26 Neutral MSH6 P52701 I225S 225 I S 0.088 Neutral MSH6 P52701 I225T 225 I T 0.092 Neutral MSH6 P52701 I225V 225 I V 0 Neutral MSH6 P52701 I225W 225 I W 0.344 Neutral MSH6 P52701 I225Y 225 I Y 0.288 Neutral MSH6 P52701 E226A 226 E A 0.068 Neutral MSH6 P52701 E226C 226 E C 0.068 Neutral MSH6 P52701 E226D 226 E D 0.004 Neutral MSH6 P52701 E226F 226 E F 0.272 Neutral MSH6 P52701 E226G 226 E G 0.024 Neutral MSH6 P52701 E226H 226 E H 0.104 Neutral MSH6 P52701 E226I 226 E I 0.254 Neutral MSH6 P52701 E226K 226 E K 0.002 Neutral MSH6 P52701 E226L 226 E L 0.286 Neutral MSH6 P52701 E226M 226 E M 0.164 Neutral MSH6 P52701 E226N 226 E N 0.056 Neutral MSH6 P52701 E226P 226 E P 0.3 Neutral MSH6 P52701 E226Q 226 E Q 0.056 Neutral MSH6 P52701 E226R 226 E R 0.01 Neutral MSH6 P52701 E226S 226 E S 0.018 Neutral MSH6 P52701 E226T 226 E T 0.168 Neutral MSH6 P52701 E226V 226 E V 0.142 Neutral MSH6 P52701 E226W 226 E W 0.43 Neutral MSH6 P52701 E226Y 226 E Y 0.338 Neutral MSH6 P52701 S227A 227 S A 0.068 Neutral MSH6 P52701 S227C 227 S C 0.032 Neutral MSH6 P52701 S227D 227 S D 0.002 Neutral MSH6 P52701 S227E 227 S E 0.138 Neutral MSH6 P52701 S227F 227 S F 0.276 Neutral MSH6 P52701 S227G 227 S G 0.036 Neutral MSH6 P52701 S227H 227 S H 0.176 Neutral MSH6 P52701 S227I 227 S I 0.026 Neutral 2 MSH6 P52701 S227K 227 S K 0.166 Neutral MSH6 P52701 S227L 227 S L 0.028 Neutral MSH6 P52701 S227M 227 S M 0.332 Neutral MSH6 P52701 S227N 227 S N 0.034 Neutral MSH6 P52701 S227P 227 S P 0.062 Neutral MSH6 P52701 S227Q 227 S Q 0.132 Neutral MSH6 P52701 S227R 227 S R 0.154 Neutral MSH6 P52701 S227T 227 S T 0.104 Neutral MSH6 P52701 S227V 227 S V 0.288 Neutral MSH6 P52701 S227W 227 S W 0.49 Neutral MSH6 P52701 S227Y 227 S Y 0.448 Neutral MSH6 P52701 E228A 228 E A 0.144 Neutral MSH6 P52701 E228C 228 E C 0.068 Neutral MSH6 P52701 E228D 228 E D 0.002 Neutral MSH6 P52701 E228F 228 E F 0.272 Neutral MSH6 P52701 E228G 228 E G 0.054 Neutral MSH6 P52701 E228H 228 E H 0.162 Neutral MSH6 P52701 E228I 228 E I 0.284 Neutral MSH6 P52701 E228K 228 E K 0.002 Neutral MSH6 P52701 E228L 228 E L 0.286 Neutral MSH6 P52701 E228M 228 E M 0.164 Neutral MSH6 P52701 E228N 228 E N 0.056 Neutral MSH6 P52701 E228P 228 E P 0.282 Neutral MSH6 P52701 E228Q 228 E Q 0.056 Neutral MSH6 P52701 E228R 228 E R 0.01 Neutral MSH6 P52701 E228S 228 E S 0.014 Neutral MSH6 P52701 E228T 228 E T 0.14 Neutral MSH6 P52701 E228V 228 E V 0.038 Neutral MSH6 P52701 E228W 228 E W 0.43 Neutral MSH6 P52701 E228Y 228 E Y 0.338 Neutral MSH6 P52701 E229A 229 E A 0.144 Neutral MSH6 P52701 E229C 229 E C 0.068 Neutral MSH6 P52701 E229D 229 E D 0 Neutral MSH6 P52701 E229F 229 E F 0.312 Neutral MSH6 P52701 E229G 229 E G 0.084 Neutral MSH6 P52701 E229H 229 E H 0.104 Neutral MSH6 P52701 E229I 229 E I 0.128 Neutral MSH6 P52701 E229K 229 E K 0.002 Neutral MSH6 P52701 E229L 229 E L 0.042 Neutral MSH6 P52701 E229M 229 E M 0.164 Neutral MSH6 P52701 E229N 229 E N 0.006 Neutral MSH6 P52701 E229P 229 E P 0.3 Neutral MSH6 P52701 E229Q 229 E Q 0.018 Neutral MSH6 P52701 E229R 229 E R 0.01 Neutral MSH6 P52701 E229S 229 E S 0.018 Neutral MSH6 P52701 E229T 229 E T 0.14 Neutral MSH6 P52701 E229V 229 E V 0.066 Neutral MSH6 P52701 E229W 229 E W 0.43 Neutral MSH6 P52701 E229Y 229 E Y 0.398 Neutral MSH6 P52701 A23C 23 A C 0.182 Neutral MSH6 P52701 A23D 23 A D 0.266 Neutral MSH6 P52701 A23E 23 A E 0.306 Neutral MSH6 P52701 A23F 23 A F 0.468 Neutral MSH6 P52701 A23G 23 A G 0.074 Neutral MSH6 P52701 A23H 23 A H 0.304 Neutral MSH6 P52701 A23I 23 A I 0.406 Neutral MSH6 P52701 A23K 23 A K 0.32 Neutral MSH6 P52701 A23L 23 A L 0.4 Neutral MSH6 P52701 A23M 23 A M 0.29 Neutral MSH6 P52701 A23N 23 A N 0.274 Neutral MSH6 P52701 A23P 23 A P 0.038 Neutral MSH6 P52701 A23Q 23 A Q 0.286 Neutral MSH6 P52701 A23R 23 A R 0.36 Neutral MSH6 P52701 A23S 23 A S 0.008 Neutral MSH6 P52701 A23T 23 A T 0.166 Neutral MSH6 P52701 A23V 23 A V 0.202 Neutral MSH6 P52701 A23W 23 A W 0.504 Pathogenic MSH6 P52701 A23Y 23 A Y 0.5 Pathogenic MSH6 P52701 E230A 230 E A 0.212 Neutral MSH6 P52701 E230C 230 E C 0.068 Neutral MSH6 P52701 E230D 230 E D 0.048 Neutral MSH6 P52701 E230F 230 E F 0.164 Neutral MSH6 P52701 E230G 230 E G 0 Neutral MSH6 P52701 E230H 230 E H 0.162 Neutral MSH6 P52701 E230I 230 E I 0.12 Neutral MSH6 P52701 E230K 230 E K 0.002 Neutral MSH6 P52701 E230L 230 E L 0.286 Neutral MSH6 P52701 E230M 230 E M 0.164 Neutral MSH6 P52701 E230N 230 E N 0.002 Neutral MSH6 P52701 E230P 230 E P 0.282 Neutral MSH6 P52701 E230Q 230 E Q 0.056 Neutral MSH6 P52701 E230R 230 E R 0.016 Neutral MSH6 P52701 E230S 230 E S 0.014 Neutral MSH6 P52701 E230T 230 E T 0.168 Neutral MSH6 P52701 E230V 230 E V 0.04 Neutral MSH6 P52701 E230W 230 E W 0.43 Neutral MSH6 P52701 E230Y 230 E Y 0.398 Neutral MSH6 P52701 V231A 231 V A 0 Neutral MSH6 P52701 V231C 231 V C 0.058 Neutral MSH6 P52701 V231D 231 V D 0.126 Neutral MSH6 P52701 V231E 231 V E 0.044 Neutral MSH6 P52701 V231F 231 V F 0.142 Neutral MSH6 P52701 V231G 231 V G 0.196 Neutral MSH6 P52701 V231H 231 V H 0.068 Neutral MSH6 P52701 V231I 231 V I 0.004 Neutral MSH6 P52701 V231K 231 V K 0.064 Neutral MSH6 P52701 V231L 231 V L 0 Neutral MSH6 P52701 V231M 231 V M 0.014 Neutral MSH6 P52701 V231N 231 V N 0.038 Neutral MSH6 P52701 V231P 231 V P 0.19 Neutral MSH6 P52701 V231Q 231 V Q 0.158 Neutral MSH6 P52701 V231R 231 V R 0.228 Neutral MSH6 P52701 V231S 231 V S 0.064 Neutral MSH6 P52701 V231T 231 V T 0.03 Neutral MSH6 P52701 V231W 231 V W 0.344 Neutral MSH6 P52701 V231Y 231 V Y 0.18 Neutral MSH6 P52701 Q232A 232 Q A 0.1 Neutral MSH6 P52701 Q232C 232 Q C 0.082 Neutral MSH6 P52701 Q232D 232 Q D 0.054 Neutral MSH6 P52701 Q232E 232 Q E 0.008 Neutral MSH6 P52701 Q232F 232 Q F 0.362 Neutral MSH6 P52701 Q232G 232 Q G 0.03 Neutral MSH6 P52701 Q232H 232 Q H 0.214 Neutral MSH6 P52701 Q232I 232 Q I 0.278 Neutral MSH6 P52701 Q232K 232 Q K 0.022 Neutral MSH6 P52701 Q232L 232 Q L 0.116 Neutral MSH6 P52701 Q232M 232 Q M 0.186 Neutral MSH6 P52701 Q232N 232 Q N 0.064 Neutral MSH6 P52701 Q232P 232 Q P 0.218 Neutral MSH6 P52701 Q232R 232 Q R 0.002 Neutral MSH6 P52701 Q232S 232 Q S 0.036 Neutral MSH6 P52701 Q232T 232 Q T 0.144 Neutral MSH6 P52701 Q232V 232 Q V 0.012 Neutral MSH6 P52701 Q232W 232 Q W 0.42 Neutral MSH6 P52701 Q232Y 232 Q Y 0.362 Neutral MSH6 P52701 P233A 233 P A 0.034 Neutral MSH6 P52701 P233C 233 P C 0.126 Neutral MSH6 P52701 P233D 233 P D 0.008 Neutral MSH6 P52701 P233E 233 P E 0.054 Neutral MSH6 P52701 P233F 233 P F 0.226 Neutral MSH6 P52701 P233G 233 P G 0.07 Neutral MSH6 P52701 P233H 233 P H 0.266 Neutral MSH6 P52701 P233I 233 P I 0.088 Neutral MSH6 P52701 P233K 233 P K 0.06 Neutral MSH6 P52701 P233L 233 P L 0.096 Neutral MSH6 P52701 P233M 233 P M 0.146 Neutral MSH6 P52701 P233N 233 P N 0.068 Neutral MSH6 P52701 P233Q 233 P Q 0.096 Neutral MSH6 P52701 P233R 233 P R 0.222 Neutral MSH6 P52701 P233S 233 P S 0.002 Neutral MSH6 P52701 P233T 233 P T 0.084 Neutral MSH6 P52701 P233V 233 P V 0.184 Neutral MSH6 P52701 P233W 233 P W 0.39 Neutral MSH6 P52701 P233Y 233 P Y 0.27 Neutral MSH6 P52701 K234A 234 K A 0.028 Neutral MSH6 P52701 K234C 234 K C 0.028 Neutral MSH6 P52701 K234D 234 K D 0.002 Neutral MSH6 P52701 K234E 234 K E 0.01 Neutral MSH6 P52701 K234F 234 K F 0.23 Neutral MSH6 P52701 K234G 234 K G 0.116 Neutral MSH6 P52701 K234H 234 K H 0.048 Neutral MSH6 P52701 K234I 234 K I 0.058 Neutral MSH6 P52701 K234L 234 K L 0.148 Neutral MSH6 P52701 K234M 234 K M 0.106 Neutral MSH6 P52701 K234N 234 K N 0.05 Neutral MSH6 P52701 K234P 234 K P 0.01 Neutral MSH6 P52701 K234Q 234 K Q 0.09 Neutral MSH6 P52701 K234R 234 K R 0.004 Neutral MSH6 P52701 K234S 234 K S 0.014 Neutral MSH6 P52701 K234T 234 K T 0.18 Neutral MSH6 P52701 K234V 234 K V 0.026 Neutral MSH6 P52701 K234W 234 K W 0.396 Neutral MSH6 P52701 K234Y 234 K Y 0.326 Neutral MSH6 P52701 T235A 235 T A 0.08 Neutral MSH6 P52701 T235C 235 T C 0.064 Neutral MSH6 P52701 T235D 235 T D 0.02 Neutral MSH6 P52701 T235E 235 T E 0.024 Neutral MSH6 P52701 T235F 235 T F 0.204 Neutral MSH6 P52701 T235G 235 T G 0.036 Neutral MSH6 P52701 T235H 235 T H 0.084 Neutral MSH6 P52701 T235I 235 T I 0.048 Neutral MSH6 P52701 T235K 235 T K 0.032 Neutral MSH6 P52701 T235L 235 T L 0.074 Neutral MSH6 P52701 T235M 235 T M 0.024 Neutral MSH6 P52701 T235N 235 T N 0 Neutral MSH6 P52701 T235P 235 T P 0.1 Neutral MSH6 P52701 T235Q 235 T Q 0.052 Neutral MSH6 P52701 T235R 235 T R 0.156 Neutral MSH6 P52701 T235S 235 T S 0 Neutral MSH6 P52701 T235V 235 T V 0.018 Neutral MSH6 P52701 T235W 235 T W 0.466 Neutral MSH6 P52701 T235Y 235 T Y 0.424 Neutral MSH6 P52701 Q236A 236 Q A 0.138 Neutral MSH6 P52701 Q236C 236 Q C 0.082 Neutral MSH6 P52701 Q236D 236 Q D 0 Neutral MSH6 P52701 Q236E 236 Q E 0.008 Neutral MSH6 P52701 Q236F 236 Q F 0.26 Neutral MSH6 P52701 Q236G 236 Q G 0.106 Neutral MSH6 P52701 Q236H 236 Q H 0.262 Neutral MSH6 P52701 Q236I 236 Q I 0.278 Neutral MSH6 P52701 Q236K 236 Q K 0.054 Neutral MSH6 P52701 Q236L 236 Q L 0.242 Neutral MSH6 P52701 Q236M 236 Q M 0.186 Neutral MSH6 P52701 Q236N 236 Q N 0.082 Neutral MSH6 P52701 Q236P 236 Q P 0.368 Neutral MSH6 P52701 Q236R 236 Q R 0.022 Neutral MSH6 P52701 Q236S 236 Q S 0.036 Neutral MSH6 P52701 Q236T 236 Q T 0.144 Neutral MSH6 P52701 Q236V 236 Q V 0.092 Neutral MSH6 P52701 Q236W 236 Q W 0.42 Neutral MSH6 P52701 Q236Y 236 Q Y 0.362 Neutral MSH6 P52701 G237A 237 G A 0.018 Neutral MSH6 P52701 G237C 237 G C 0.14 Neutral MSH6 P52701 G237D 237 G D 0.134 Neutral MSH6 P52701 G237E 237 G E 0.192 Neutral MSH6 P52701 G237F 237 G F 0.498 Neutral MSH6 P52701 G237H 237 G H 0.442 Neutral MSH6 P52701 G237I 237 G I 0.412 Neutral MSH6 P52701 G237K 237 G K 0.312 Neutral MSH6 P52701 G237L 237 G L 0.37 Neutral MSH6 P52701 G237M 237 G M 0.34 Neutral MSH6 P52701 G237N 237 G N 0.252 Neutral MSH6 P52701 G237P 237 G P 0.392 Neutral MSH6 P52701 G237Q 237 G Q 0.262 Neutral MSH6 P52701 G237R 237 G R 0.3 Neutral MSH6 P52701 G237S 237 G S 0.018 Neutral MSH6 P52701 G237T 237 G T 0.274 Neutral MSH6 P52701 G237V 237 G V 0.318 Neutral MSH6 P52701 G237W 237 G W 0.498 Neutral MSH6 P52701 G237Y 237 G Y 0.44 Neutral MSH6 P52701 S238A 238 S A 0.01 Neutral MSH6 P52701 S238C 238 S C 0.032 Neutral MSH6 P52701 S238D 238 S D 0.002 Neutral MSH6 P52701 S238E 238 S E 0.138 Neutral MSH6 P52701 S238F 238 S F 0.276 Neutral MSH6 P52701 S238G 238 S G 0.01 Neutral MSH6 P52701 S238H 238 S H 0.238 Neutral MSH6 P52701 S238I 238 S I 0.026 Neutral MSH6 P52701 S238K 238 S K 0.15 Neutral MSH6 P52701 S238L 238 S L 0.028 Neutral MSH6 P52701 S238M 238 S M 0.28 Neutral MSH6 P52701 S238N 238 S N 0.034 Neutral MSH6 P52701 S238P 238 S P 0.062 Neutral MSH6 P52701 S238Q 238 S Q 0.132 Neutral MSH6 P52701 S238R 238 S R 0.17 Neutral MSH6 P52701 S238T 238 S T 0.104 Neutral MSH6 P52701 S238V 238 S V 0.288 Neutral MSH6 P52701 S238W 238 S W 0.49 Neutral MSH6 P52701 S238Y 238 S Y 0.448 Neutral MSH6 P52701 R239A 239 R A 0.126 Neutral MSH6 P52701 R239C 239 R C 0.148 Neutral MSH6 P52701 R239D 239 R D 0.02 Neutral MSH6 P52701 R239E 239 R E 0.02 Neutral MSH6 P52701 R239F 239 R F 0.28 Neutral MSH6 P52701 R239G 239 R G 0.002 Neutral MSH6 P52701 R239H 239 R H 0.12 Neutral MSH6 P52701 R239I 239 R I 0.194 Neutral MSH6 P52701 R239K 239 R K 0.004 Neutral MSH6 P52701 R239L 239 R L 0.23 Neutral MSH6 P52701 R239M 239 R M 0.066 Neutral MSH6 P52701 R239N 239 R N 0.198 Neutral MSH6 P52701 R239P 239 R P 0.028 Neutral MSH6 P52701 R239Q 239 R Q 0.25 Neutral MSH6 P52701 R239S 239 R S 0.02 Neutral MSH6 P52701 R239T 239 R T 0.142 Neutral MSH6 P52701 R239V 239 R V 0.056 Neutral MSH6 P52701 R239W 239 R W 0.384 Neutral MSH6 P52701 R239Y 239 R Y 0.284 Neutral MSH6 P52701 S24A 24 S A 0.01 Neutral MSH6 P52701 S24C 24 S C 0.032 Neutral MSH6 P52701 S24D 24 S D 0.044 Neutral MSH6 P52701 S24E 24 S E 0.148 Neutral MSH6 P52701 S24F 24 S F 0.276 Neutral MSH6 P52701 S24G 24 S G 0.064 Neutral MSH6 P52701 S24H 24 S H 0.238 Neutral MSH6 P52701 S24I 24 S I 0.026 Neutral MSH6 P52701 S24K 24 S K 0.164 Neutral MSH6 P52701 S24L 24 S L 0.028 Neutral MSH6 P52701 S24M 24 S M 0.332 Neutral MSH6 P52701 S24N 24 S N 0.012 Neutral MSH6 P52701 S24P 24 S P 0.062 Neutral MSH6 P52701 S24Q 24 S Q 0.158 Neutral MSH6 P52701 S24R 24 S R 0.248 Neutral MSH6 P52701 S24T 24 S T 0.11 Neutral MSH6 P52701 S24V 24 S V 0.248 Neutral MSH6 P52701 S24W 24 S W 0.49 Neutral MSH6 P52701 S24Y 24 S Y 0.448 Neutral MSH6 P52701 R240A 240 R A 0.08 Neutral MSH6 P52701 R240C 240 R C 0.14 Neutral MSH6 P52701 R240D 240 R D 0.022 Neutral MSH6 P52701 R240E 240 R E 0.162 Neutral MSH6 P52701 R240F 240 R F 0.28 Neutral MSH6 P52701 R240G 240 R G 0.1 Neutral MSH6 P52701 R240H 240 R H 0.12 Neutral MSH6 P52701 R240I 240 R I 0.116 Neutral MSH6 P52701 R240K 240 R K 0.004 Neutral MSH6 P52701 R240L 240 R L 0.062 Neutral MSH6 P52701 R240M 240 R M 0.164 Neutral MSH6 P52701 R240N 240 R N 0.01 Neutral MSH6 P52701 R240P 240 R P 0.262 Neutral MSH6 P52701 R240Q 240 R Q 0.116 Neutral MSH6 P52701 R240S 240 R S 0.016 Neutral MSH6 P52701 R240T 240 R T 0.026 Neutral MSH6 P52701 R240V 240 R V 0.056 Neutral MSH6 P52701 R240W 240 R W 0.384 Neutral MSH6 P52701 R240Y 240 R Y 0.284 Neutral MSH6 P52701 S241A 241 S A 0.01 Neutral MSH6 P52701 S241C 241 S C 0.032 Neutral MSH6 P52701 S241D 241 S D 0.008 Neutral MSH6 P52701 S241E 241 S E 0.142 Neutral MSH6 P52701 S241F 241 S F 0.276 Neutral MSH6 P52701 S241G 241 S G 0 Neutral MSH6 P52701 S241H 241 S H 0.238 Neutral MSH6 P52701 S241I 241 S I 0.026 Neutral MSH6 P52701 S241K 241 S K 0.166 Neutral MSH6 P52701 S241L 241 S L 0.068 Neutral MSH6 P52701 S241M 241 S M 0.332 Neutral MSH6 P52701 S241N 241 S N 0.034 Neutral MSH6 P52701 S241P 241 S P 0.098 Neutral MSH6 P52701 S241Q 241 S Q 0.17 Neutral MSH6 P52701 S241R 241 S R 0.154 Neutral MSH6 P52701 S241T 241 S T 0.104 Neutral MSH6 P52701 S241V 241 S V 0.032 Neutral MSH6 P52701 S241W 241 S W 0.448 Neutral MSH6 P52701 S241Y 241 S Y 0.448 Neutral MSH6 P52701 S242A 242 S A 0.086 Neutral MSH6 P52701 S242C 242 S C 0.032 Neutral MSH6 P52701 S242D 242 S D 0.004 Neutral MSH6 P52701 S242E 242 S E 0.138 Neutral MSH6 P52701 S242F 242 S F 0.264 Neutral MSH6 P52701 S242G 242 S G 0 Neutral MSH6 P52701 S242H 242 S H 0.188 Neutral MSH6 P52701 S242I 242 S I 0.194 Neutral MSH6 P52701 S242K 242 S K 0.164 Neutral MSH6 P52701 S242L 242 S L 0.042 Neutral MSH6 P52701 S242M 242 S M 0.252 Neutral MSH6 P52701 S242N 242 S N 0.018 Neutral MSH6 P52701 S242P 242 S P 0.062 Neutral MSH6 P52701 S242Q 242 S Q 0.132 Neutral MSH6 P52701 S242R 242 S R 0.136 Neutral MSH6 P52701 S242T 242 S T 0.046 Neutral MSH6 P52701 S242V 242 S V 0.288 Neutral MSH6 P52701 S242W 242 S W 0.49 Neutral MSH6 P52701 S242Y 242 S Y 0.448 Neutral MSH6 P52701 R243A 243 R A 0.038 Neutral MSH6 P52701 R243C 243 R C 0.14 Neutral MSH6 P52701 R243D 243 R D 0.018 Neutral MSH6 P52701 R243E 243 R E 0.03 Neutral MSH6 P52701 R243F 243 R F 0.038 Neutral MSH6 P52701 R243G 243 R G 0.006 Neutral MSH6 P52701 R243H 243 R H 0.07 Neutral MSH6 P52701 R243I 243 R I 0.308 Neutral MSH6 P52701 R243K 243 R K 0.004 Neutral MSH6 P52701 R243L 243 R L 0.23 Neutral MSH6 P52701 R243M 243 R M 0.164 Neutral MSH6 P52701 R243N 243 R N 0.01 Neutral MSH6 P52701 R243P 243 R P 0.236 Neutral MSH6 P52701 R243Q 243 R Q 0.16 Neutral MSH6 P52701 R243S 243 R S 0.02 Neutral MSH6 P52701 R243T 243 R T 0.066 Neutral MSH6 P52701 R243V 243 R V 0.178 Neutral MSH6 P52701 R243W 243 R W 0.384 Neutral MSH6 P52701 R243Y 243 R Y 0.284 Neutral MSH6 P52701 Q244A 244 Q A 0.036 Neutral MSH6 P52701 Q244C 244 Q C 0.082 Neutral MSH6 P52701 Q244D 244 Q D 0.006 Neutral MSH6 P52701 Q244E 244 Q E 0.008 Neutral MSH6 P52701 Q244F 244 Q F 0.362 Neutral MSH6 P52701 Q244G 244 Q G 0.03 Neutral MSH6 P52701 Q244H 244 Q H 0.14 Neutral MSH6 P52701 Q244I 244 Q I 0.278 Neutral MSH6 P52701 Q244K 244 Q K 0.222 Neutral MSH6 P52701 Q244L 244 Q L 0.242 Neutral MSH6 P52701 Q244M 244 Q M 0.186 Neutral MSH6 P52701 Q244N 244 Q N 0.094 Neutral MSH6 P52701 Q244P 244 Q P 0.368 Neutral MSH6 P52701 Q244R 244 Q R 0.002 Neutral MSH6 P52701 Q244S 244 Q S 0.038 Neutral MSH6 P52701 Q244T 244 Q T 0.014 Neutral MSH6 P52701 Q244V 244 Q V 0.092 Neutral MSH6 P52701 Q244W 244 Q W 0.42 Neutral MSH6 P52701 Q244Y 244 Q Y 0.452 Neutral MSH6 P52701 I245A 245 I A 0.006 Neutral MSH6 P52701 I245C 245 I C 0.09 Neutral MSH6 P52701 I245D 245 I D 0.042 Neutral MSH6 P52701 I245E 245 I E 0.14 Neutral MSH6 P52701 I245F 245 I F 0.07 Neutral MSH6 P52701 I245G 245 I G 0.106 Neutral MSH6 P52701 I245H 245 I H 0.08 Neutral MSH6 P52701 I245K 245 I K 0.046 Neutral MSH6 P52701 I245L 245 I L 0.058 Neutral MSH6 P52701 I245M 245 I M 0.112 Neutral MSH6 P52701 I245N 245 I N 0.112 Neutral MSH6 P52701 I245P 245 I P 0.062 Neutral MSH6 P52701 I245Q 245 I Q 0.138 Neutral MSH6 P52701 I245R 245 I R 0.23 Neutral MSH6 P52701 I245S 245 I S 0.076 Neutral MSH6 P52701 I245T 245 I T 0.002 Neutral MSH6 P52701 I245V 245 I V 0 Neutral MSH6 P52701 I245W 245 I W 0.344 Neutral MSH6 P52701 I245Y 245 I Y 0.3 Neutral MSH6 P52701 K246A 246 K A 0.028 Neutral MSH6 P52701 K246C 246 K C 0.028 Neutral MSH6 P52701 K246D 246 K D 0.05 Neutral MSH6 P52701 K246E 246 K E 0.03 Neutral MSH6 P52701 K246F 246 K F 0.114 Neutral MSH6 P52701 K246G 246 K G 0.044 Neutral MSH6 P52701 K246H 246 K H 0.048 Neutral MSH6 P52701 K246I 246 K I 0.222 Neutral MSH6 P52701 K246L 246 K L 0.148 Neutral MSH6 P52701 K246M 246 K M 0.146 Neutral MSH6 P52701 K246N 246 K N 0.006 Neutral MSH6 P52701 K246P 246 K P 0.214 Neutral MSH6 P52701 K246Q 246 K Q 0.006 Neutral MSH6 P52701 K246R 246 K R 0.012 Neutral MSH6 P52701 K246S 246 K S 0.014 Neutral MSH6 P52701 K246T 246 K T 0.18 Neutral MSH6 P52701 K246V 246 K V 0.12 Neutral MSH6 P52701 K246W 246 K W 0.396 Neutral MSH6 P52701 K246Y 246 K Y 0.324 Neutral MSH6 P52701 K247A 247 K A 0.028 Neutral MSH6 P52701 K247C 247 K C 0.028 Neutral MSH6 P52701 K247D 247 K D 0.046 Neutral MSH6 P52701 K247E 247 K E 0.004 Neutral MSH6 P52701 K247F 247 K F 0.212 Neutral MSH6 P52701 K247G 247 K G 0.062 Neutral MSH6 P52701 K247H 247 K H 0.048 Neutral MSH6 P52701 K247I 247 K I 0.124 Neutral MSH6 P52701 K247L 247 K L 0.214 Neutral MSH6 P52701 K247M 247 K M 0.106 Neutral MSH6 P52701 K247N 247 K N 0.046 Neutral MSH6 P52701 K247P 247 K P 0.01 Neutral MSH6 P52701 K247Q 247 K Q 0.09 Neutral MSH6 P52701 K247R 247 K R 0.002 Neutral MSH6 P52701 K247S 247 K S 0.014 Neutral MSH6 P52701 K247T 247 K T 0.028 Neutral MSH6 P52701 K247V 247 K V 0.18 Neutral MSH6 P52701 K247W 247 K W 0.396 Neutral MSH6 P52701 K247Y 247 K Y 0.326 Neutral MSH6 P52701 R248A 248 R A 0.126 Neutral MSH6 P52701 R248C 248 R C 0.148 Neutral MSH6 P52701 R248D 248 R D 0.02 Neutral MSH6 P52701 R248E 248 R E 0.02 Neutral MSH6 P52701 R248F 248 R F 0.27 Neutral MSH6 P52701 R248G 248 R G 0.006 Neutral MSH6 P52701 R248H 248 R H 0.12 Neutral MSH6 P52701 R248I 248 R I 0.304 Neutral MSH6 P52701 R248K 248 R K 0.004 Neutral MSH6 P52701 R248L 248 R L 0.062 Neutral MSH6 P52701 R248M 248 R M 0.15 Neutral MSH6 P52701 R248N 248 R N 0.07 Neutral MSH6 P52701 R248P 248 R P 0.062 Neutral MSH6 P52701 R248Q 248 R Q 0.012 Neutral MSH6 P52701 R248S 248 R S 0.016 Neutral MSH6 P52701 R248T 248 R T 0.066 Neutral MSH6 P52701 R248V 248 R V 0.242 Neutral MSH6 P52701 R248W 248 R W 0.384 Neutral MSH6 P52701 R248Y 248 R Y 0.342 Neutral MSH6 P52701 R249A 249 R A 0.036 Neutral MSH6 P52701 R249C 249 R C 0.148 Neutral MSH6 P52701 R249D 249 R D 0.024 Neutral MSH6 P52701 R249E 249 R E 0.024 Neutral MSH6 P52701 R249F 249 R F 0.28 Neutral MSH6 P52701 R249G 249 R G 0.002 Neutral MSH6 P52701 R249H 249 R H 0.12 Neutral MSH6 P52701 R249I 249 R I 0.304 Neutral MSH6 P52701 R249K 249 R K 0.006 Neutral MSH6 P52701 R249L 249 R L 0.272 Neutral MSH6 P52701 R249M 249 R M 0.15 Neutral MSH6 P52701 R249N 249 R N 0.01 Neutral MSH6 P52701 R249P 249 R P 0.236 Neutral MSH6 P52701 R249Q 249 R Q 0.25 Neutral MSH6 P52701 R249S 249 R S 0.016 Neutral MSH6 P52701 R249T 249 R T 0.066 Neutral MSH6 P52701 R249V 249 R V 0.242 Neutral MSH6 P52701 R249W 249 R W 0.448 Neutral MSH6 P52701 R249Y 249 R Y 0.284 Neutral MSH6 P52701 A25C 25 A C 0.182 Neutral MSH6 P52701 A25D 25 A D 0.266 Neutral MSH6 P52701 A25E 25 A E 0.306 Neutral MSH6 P52701 A25F 25 A F 0.468 Neutral MSH6 P52701 A25G 25 A G 0.154 Neutral MSH6 P52701 A25H 25 A H 0.304 Neutral MSH6 P52701 A25I 25 A I 0.406 Neutral MSH6 P52701 A25K 25 A K 0.354 Neutral MSH6 P52701 A25L 25 A L 0.4 Neutral MSH6 P52701 A25M 25 A M 0.29 Neutral MSH6 P52701 A25N 25 A N 0.274 Neutral MSH6 P52701 A25P 25 A P 0.04 Neutral MSH6 P52701 A25Q 25 A Q 0.302 Neutral MSH6 P52701 A25R 25 A R 0.318 Neutral MSH6 P52701 A25S 25 A S 0.068 Neutral MSH6 P52701 A25T 25 A T 0.014 Neutral MSH6 P52701 A25V 25 A V 0.136 Neutral MSH6 P52701 A25W 25 A W 0.504 Pathogenic MSH6 P52701 A25Y 25 A Y 0.5 Pathogenic MSH6 P52701 V250A 250 V A 0.01 Neutral MSH6 P52701 V250C 250 V C 0.058 Neutral MSH6 P52701 V250D 250 V D 0.034 Neutral MSH6 P52701 V250E 250 V E 0.042 Neutral MSH6 P52701 V250F 250 V F 0.172 Neutral MSH6 P52701 V250G 250 V G 0.04 Neutral MSH6 P52701 V250H 250 V H 0.112 Neutral MSH6 P52701 V250I 250 V I 0.038 Neutral MSH6 P52701 V250K 250 V K 0.074 Neutral MSH6 P52701 V250L 250 V L 0.018 Neutral MSH6 P52701 V250M 250 V M 0.03 Neutral MSH6 P52701 V250N 250 V N 0.144 Neutral MSH6 P52701 V250P 250 V P 0.088 Neutral MSH6 P52701 V250Q 250 V Q 0.216 Neutral MSH6 P52701 V250R 250 V R 0.226 Neutral MSH6 P52701 V250S 250 V S 0.01 Neutral MSH6 P52701 V250T 250 V T 0.094 Neutral MSH6 P52701 V250W 250 V W 0.344 Neutral MSH6 P52701 V250Y 250 V Y 0.18 Neutral MSH6 P52701 I251A 251 I A 0.006 Neutral MSH6 P52701 I251C 251 I C 0.09 Neutral MSH6 P52701 I251D 251 I D 0.088 Neutral MSH6 P52701 I251E 251 I E 0.028 Neutral MSH6 P52701 I251F 251 I F 0.206 Neutral MSH6 P52701 I251G 251 I G 0.192 Neutral MSH6 P52701 I251H 251 I H 0.046 Neutral MSH6 P52701 I251K 251 I K 0.046 Neutral MSH6 P52701 I251L 251 I L 0.012 Neutral MSH6 P52701 I251M 251 I M 0.112 Neutral MSH6 P52701 I251N 251 I N 0.096 Neutral MSH6 P52701 I251P 251 I P 0.172 Neutral MSH6 P52701 I251Q 251 I Q 0.108 Neutral MSH6 P52701 I251R 251 I R 0.248 Neutral MSH6 P52701 I251S 251 I S 0.072 Neutral MSH6 P52701 I251T 251 I T 0.192 Neutral MSH6 P52701 I251V 251 I V 0 Neutral MSH6 P52701 I251W 251 I W 0.344 Neutral MSH6 P52701 I251Y 251 I Y 0.298 Neutral MSH6 P52701 S252A 252 S A 0.018 Neutral MSH6 P52701 S252C 252 S C 0.032 Neutral MSH6 P52701 S252D 252 S D 0.024 Neutral MSH6 P52701 S252E 252 S E 0.138 Neutral MSH6 P52701 S252F 252 S F 0.276 Neutral MSH6 P52701 S252G 252 S G 0 Neutral MSH6 P52701 S252H 252 S H 0.238 Neutral MSH6 P52701 S252I 252 S I 0.196 Neutral MSH6 P52701 S252K 252 S K 0.162 Neutral MSH6 P52701 S252L 252 S L 0.028 Neutral MSH6 P52701 S252M 252 S M 0.332 Neutral MSH6 P52701 S252N 252 S N 0.018 Neutral MSH6 P52701 S252P 252 S P 0.116 Neutral MSH6 P52701 S252Q 252 S Q 0.158 Neutral MSH6 P52701 S252R 252 S R 0.138 Neutral MSH6 P52701 S252T 252 S T 0.176 Neutral MSH6 P52701 S252V 252 S V 0.032 Neutral MSH6 P52701 S252W 252 S W 0.49 Neutral MSH6 P52701 S252Y 252 S Y 0.448 Neutral MSH6 P52701 D253A 253 D A 0.028 Neutral MSH6 P52701 D253C 253 D C 0.148 Neutral MSH6 P52701 D253E 253 D E 0.014 Neutral MSH6 P52701 D253F 253 D F 0.406 Neutral MSH6 P52701 D253G 253 D G 0.018 Neutral MSH6 P52701 D253H 253 D H 0.154 Neutral MSH6 P52701 D253I 253 D I 0.302 Neutral MSH6 P52701 D253K 253 D K 0.112 Neutral MSH6 P52701 D253L 253 D L 0.024 Neutral MSH6 P52701 D253M 253 D M 0.106 Neutral MSH6 P52701 D253N 253 D N 0.02 Neutral MSH6 P52701 D253P 253 D P 0.038 Neutral MSH6 P52701 D253Q 253 D Q 0.112 Neutral MSH6 P52701 D253R 253 D R 0.152 Neutral MSH6 P52701 D253S 253 D S 0.002 Neutral MSH6 P52701 D253T 253 D T 0.012 Neutral MSH6 P52701 D253V 253 D V 0.07 Neutral MSH6 P52701 D253W 253 D W 0.434 Neutral MSH6 P52701 D253Y 253 D Y 0.432 Neutral MSH6 P52701 S254A 254 S A 0.052 Neutral MSH6 P52701 S254C 254 S C 0.032 Neutral MSH6 P52701 S254D 254 S D 0.002 Neutral MSH6 P52701 S254E 254 S E 0.122 Neutral MSH6 P52701 S254F 254 S F 0.276 Neutral MSH6 P52701 S254G 254 S G 0.002 Neutral MSH6 P52701 S254H 254 S H 0.238 Neutral MSH6 P52701 S254I 254 S I 0.196 Neutral MSH6 P52701 S254K 254 S K 0.162 Neutral MSH6 P52701 S254L 254 S L 0.028 Neutral MSH6 P52701 S254M 254 S M 0.28 Neutral MSH6 P52701 S254N 254 S N 0.012 Neutral MSH6 P52701 S254P 254 S P 0.098 Neutral MSH6 P52701 S254Q 254 S Q 0.158 Neutral MSH6 P52701 S254R 254 S R 0.138 Neutral MSH6 P52701 S254T 254 S T 0.176 Neutral MSH6 P52701 S254V 254 S V 0.034 Neutral MSH6 P52701 S254W 254 S W 0.49 Neutral MSH6 P52701 S254Y 254 S Y 0.448 Neutral MSH6 P52701 E255A 255 E A 0.212 Neutral MSH6 P52701 E255C 255 E C 0.068 Neutral MSH6 P52701 E255D 255 E D 0.002 Neutral MSH6 P52701 E255F 255 E F 0.282 Neutral MSH6 P52701 E255G 255 E G 0.054 Neutral MSH6 P52701 E255H 255 E H 0.164 Neutral MSH6 P52701 E255I 255 E I 0.334 Neutral MSH6 P52701 E255K 255 E K 0.068 Neutral MSH6 P52701 E255L 255 E L 0.146 Neutral MSH6 P52701 E255M 255 E M 0.172 Neutral MSH6 P52701 E255N 255 E N 0.04 Neutral MSH6 P52701 E255P 255 E P 0.128 Neutral MSH6 P52701 E255Q 255 E Q 0.056 Neutral MSH6 P52701 E255R 255 E R 0.01 Neutral MSH6 P52701 E255S 255 E S 0.014 Neutral MSH6 P52701 E255T 255 E T 0.176 Neutral MSH6 P52701 E255V 255 E V 0.258 Neutral MSH6 P52701 E255W 255 E W 0.448 Neutral MSH6 P52701 E255Y 255 E Y 0.358 Neutral MSH6 P52701 S256A 256 S A 0.01 Neutral MSH6 P52701 S256C 256 S C 0.032 Neutral MSH6 P52701 S256D 256 S D 0.004 Neutral MSH6 P52701 S256E 256 S E 0.122 Neutral MSH6 P52701 S256F 256 S F 0.276 Neutral MSH6 P52701 S256G 256 S G 0.064 Neutral MSH6 P52701 S256H 256 S H 0.238 Neutral MSH6 P52701 S256I 256 S I 0.17 Neutral MSH6 P52701 S256K 256 S K 0.15 Neutral MSH6 P52701 S256L 256 S L 0.062 Neutral MSH6 P52701 S256M 256 S M 0.332 Neutral MSH6 P52701 S256N 256 S N 0.018 Neutral MSH6 P52701 S256P 256 S P 0.098 Neutral MSH6 P52701 S256Q 256 S Q 0.158 Neutral MSH6 P52701 S256R 256 S R 0.152 Neutral MSH6 P52701 S256T 256 S T 0.176 Neutral MSH6 P52701 S256V 256 S V 0.248 Neutral MSH6 P52701 S256W 256 S W 0.49 Neutral MSH6 P52701 S256Y 256 S Y 0.448 Neutral MSH6 P52701 D257A 257 D A 0.072 Neutral MSH6 P52701 D257C 257 D C 0.148 Neutral MSH6 P52701 D257E 257 D E 0.014 Neutral MSH6 P52701 D257F 257 D F 0.406 Neutral MSH6 P52701 D257G 257 D G 0.17 Neutral MSH6 P52701 D257H 257 D H 0.09 Neutral MSH6 P52701 D257I 257 D I 0.302 Neutral MSH6 P52701 D257K 257 D K 0.052 Neutral MSH6 P52701 D257L 257 D L 0.054 Neutral MSH6 P52701 D257M 257 D M 0.19 Neutral MSH6 P52701 D257N 257 D N 0 Neutral MSH6 P52701 D257P 257 D P 0.288 Neutral MSH6 P52701 D257Q 257 D Q 0.112 Neutral MSH6 P52701 D257R 257 D R 0.166 Neutral MSH6 P52701 D257S 257 D S 0.002 Neutral MSH6 P52701 D257T 257 D T 0.012 Neutral MSH6 P52701 D257V 257 D V 0.242 Neutral MSH6 P52701 D257W 257 D W 0.434 Neutral MSH6 P52701 D257Y 257 D Y 0.432 Neutral MSH6 P52701 I258A 258 I A 0.06 Neutral MSH6 P52701 I258C 258 I C 0.09 Neutral MSH6 P52701 I258D 258 I D 0.03 Neutral MSH6 P52701 I258E 258 I E 0.076 Neutral MSH6 P52701 I258F 258 I F 0.088 Neutral MSH6 P52701 I258G 258 I G 0.23 Neutral MSH6 P52701 I258H 258 I H 0.08 Neutral MSH6 P52701 I258K 258 I K 0.042 Neutral MSH6 P52701 I258L 258 I L 0.15 Neutral MSH6 P52701 I258M 258 I M 0.112 Neutral MSH6 P52701 I258N 258 I N 0.112 Neutral MSH6 P52701 I258P 258 I P 0.174 Neutral MSH6 P52701 I258Q 258 I Q 0.138 Neutral MSH6 P52701 I258R 258 I R 0.23 Neutral MSH6 P52701 I258S 258 I S 0.072 Neutral MSH6 P52701 I258T 258 I T 0.092 Neutral MSH6 P52701 I258V 258 I V 0 Neutral MSH6 P52701 I258W 258 I W 0.344 Neutral MSH6 P52701 I258Y 258 I Y 0.298 Neutral MSH6 P52701 G259A 259 G A 0.01 Neutral MSH6 P52701 G259C 259 G C 0.14 Neutral MSH6 P52701 G259D 259 G D 0.138 Neutral MSH6 P52701 G259E 259 G E 0.192 Neutral MSH6 P52701 G259F 259 G F 0.478 Neutral MSH6 P52701 G259H 259 G H 0.294 Neutral MSH6 P52701 G259I 259 G I 0.412 Neutral MSH6 P52701 G259K 259 G K 0.284 Neutral MSH6 P52701 G259L 259 G L 0.316 Neutral MSH6 P52701 G259M 259 G M 0.422 Neutral MSH6 P52701 G259N 259 G N 0.168 Neutral MSH6 P52701 G259P 259 G P 0.392 Neutral MSH6 P52701 G259Q 259 G Q 0.262 Neutral MSH6 P52701 G259R 259 G R 0.304 Neutral MSH6 P52701 G259S 259 G S 0.018 Neutral MSH6 P52701 G259T 259 G T 0.274 Neutral MSH6 P52701 G259V 259 G V 0.318 Neutral MSH6 P52701 G259W 259 G W 0.498 Neutral MSH6 P52701 G259Y 259 G Y 0.5 Pathogenic MSH6 P52701 R26A 26 R A 0.086 Neutral MSH6 P52701 R26C 26 R C 0.148 Neutral MSH6 P52701 R26D 26 R D 0.18 Neutral MSH6 P52701 R26E 26 R E 0.162 Neutral MSH6 P52701 R26F 26 R F 0.28 Neutral MSH6 P52701 R26G 26 R G 0.072 Neutral MSH6 P52701 R26H 26 R H 0.12 Neutral MSH6 P52701 R26I 26 R I 0.308 Neutral MSH6 P52701 R26K 26 R K 0.004 Neutral MSH6 P52701 R26L 26 R L 0.272 Neutral MSH6 P52701 R26M 26 R M 0.164 Neutral MSH6 P52701 R26N 26 R N 0.176 Neutral MSH6 P52701 R26P 26 R P 0.262 Neutral MSH6 P52701 R26Q 26 R Q 0.16 Neutral MSH6 P52701 R26S 26 R S 0.02 Neutral MSH6 P52701 R26T 26 R T 0.164 Neutral MSH6 P52701 R26V 26 R V 0.178 Neutral MSH6 P52701 R26W 26 R W 0.384 Neutral MSH6 P52701 R26Y 26 R Y 0.284 Neutral MSH6 P52701 G260A 260 G A 0.002 Neutral MSH6 P52701 G260C 260 G C 0.14 Neutral MSH6 P52701 G260D 260 G D 0.12 Neutral MSH6 P52701 G260E 260 G E 0.192 Neutral MSH6 P52701 G260F 260 G F 0.498 Neutral MSH6 P52701 G260H 260 G H 0.37 Neutral MSH6 P52701 G260I 260 G I 0.428 Neutral MSH6 P52701 G260K 260 G K 0.416 Neutral MSH6 P52701 G260L 260 G L 0.412 Neutral MSH6 P52701 G260M 260 G M 0.422 Neutral MSH6 P52701 G260N 260 G N 0.164 Neutral MSH6 P52701 G260P 260 G P 0.362 Neutral MSH6 P52701 G260Q 260 G Q 0.262 Neutral MSH6 P52701 G260R 260 G R 0.302 Neutral MSH6 P52701 G260S 260 G S 0.046 Neutral MSH6 P52701 G260T 260 G T 0.272 Neutral MSH6 P52701 G260V 260 G V 0.318 Neutral MSH6 P52701 G260W 260 G W 0.498 Neutral MSH6 P52701 G260Y 260 G Y 0.5 Pathogenic MSH6 P52701 S261A 261 S A 0.02 Neutral MSH6 P52701 S261C 261 S C 0.054 Neutral MSH6 P52701 S261D 261 S D 0.012 Neutral MSH6 P52701 S261E 261 S E 0.224 Neutral MSH6 P52701 S261F 261 S F 0.506 Pathogenic MSH6 P52701 S261G 261 S G 0.008 Neutral MSH6 P52701 S261H 261 S H 0.434 Neutral MSH6 P52701 S261I 261 S I 0.224 Neutral MSH6 P52701 S261K 261 S K 0.24 Neutral MSH6 P52701 S261L 261 S L 0.162 Neutral MSH6 P52701 S261M 261 S M 0.544 Pathogenic MSH6 P52701 S261N 261 S N 0.062 Neutral MSH6 P52701 S261P 261 S P 0.21 Neutral MSH6 P52701 S261Q 261 S Q 0.32 Neutral MSH6 P52701 S261R 261 S R 0.44 Neutral MSH6 P52701 S261T 261 S T 0.03 Neutral MSH6 P52701 S261V 261 S V 0.058 Neutral MSH6 P52701 S261W 261 S W 0.724 Pathogenic MSH6 P52701 S261Y 261 S Y 0.686 Pathogenic MSH6 P52701 D262A 262 D A 0.024 Neutral MSH6 P52701 D262C 262 D C 0.266 Neutral MSH6 P52701 D262E 262 D E 0.024 Neutral MSH6 P52701 D262F 262 D F 0.63 Pathogenic MSH6 P52701 D262G 262 D G 0.098 Neutral MSH6 P52701 D262H 262 D H 0.164 Neutral MSH6 P52701 D262I 262 D I 0.48 Neutral MSH6 P52701 D262K 262 D K 0.154 Neutral MSH6 P52701 D262L 262 D L 0.174 Neutral MSH6 P52701 D262M 262 D M 0.342 Neutral MSH6 P52701 D262N 262 D N 0.096 Neutral MSH6 P52701 D262P 262 D P 0.06 Neutral MSH6 P52701 D262Q 262 D Q 0.184 Neutral MSH6 P52701 D262R 262 D R 0.292 Neutral MSH6 P52701 D262S 262 D S 0.006 Neutral MSH6 P52701 D262T 262 D T 0.2 Neutral MSH6 P52701 D262V 262 D V 0.254 Neutral MSH6 P52701 D262W 262 D W 0.716 Pathogenic MSH6 P52701 D262Y 262 D Y 0.688 Pathogenic MSH6 P52701 V263A 263 V A 0.01 Neutral MSH6 P52701 V263C 263 V C 0.058 Neutral MSH6 P52701 V263D 263 V D 0.028 Neutral MSH6 P52701 V263E 263 V E 0.046 Neutral MSH6 P52701 V263F 263 V F 0.176 Neutral MSH6 P52701 V263G 263 V G 0.118 Neutral MSH6 P52701 V263H 263 V H 0.116 Neutral MSH6 P52701 V263I 263 V I 0.038 Neutral MSH6 P52701 V263K 263 V K 0.158 Neutral MSH6 P52701 V263L 263 V L 0.054 Neutral MSH6 P52701 V263M 263 V M 0.012 Neutral MSH6 P52701 V263N 263 V N 0.148 Neutral MSH6 P52701 V263P 263 V P 0.198 Neutral MSH6 P52701 V263Q 263 V Q 0.23 Neutral MSH6 P52701 V263R 263 V R 0.236 Neutral MSH6 P52701 V263S 263 V S 0.01 Neutral MSH6 P52701 V263T 263 V T 0.008 Neutral MSH6 P52701 V263W 263 V W 0.348 Neutral MSH6 P52701 V263Y 263 V Y 0.26 Neutral MSH6 P52701 E264A 264 E A 0.246 Neutral MSH6 P52701 E264C 264 E C 0.13 Neutral MSH6 P52701 E264D 264 E D 0.004 Neutral MSH6 P52701 E264F 264 E F 0.44 Neutral MSH6 P52701 E264G 264 E G 0.118 Neutral MSH6 P52701 E264H 264 E H 0.18 Neutral MSH6 P52701 E264I 264 E I 0.464 Neutral MSH6 P52701 E264K 264 E K 0.276 Neutral MSH6 P52701 E264L 264 E L 0.462 Neutral MSH6 P52701 E264M 264 E M 0.302 Neutral MSH6 P52701 E264N 264 E N 0.056 Neutral MSH6 P52701 E264P 264 E P 0.474 Neutral MSH6 P52701 E264Q 264 E Q 0.092 Neutral MSH6 P52701 E264R 264 E R 0.074 Neutral MSH6 P52701 E264S 264 E S 0.02 Neutral MSH6 P52701 E264T 264 E T 0.228 Neutral MSH6 P52701 E264V 264 E V 0.412 Neutral MSH6 P52701 E264W 264 E W 0.712 Pathogenic MSH6 P52701 E264Y 264 E Y 0.598 Pathogenic MSH6 P52701 F265A 265 F A 0.112 Neutral MSH6 P52701 F265C 265 F C 0.088 Neutral MSH6 P52701 F265D 265 F D 0.026 Neutral MSH6 P52701 F265E 265 F E 0.046 Neutral MSH6 P52701 F265G 265 F G 0.136 Neutral MSH6 P52701 F265H 265 F H 0.052 Neutral MSH6 P52701 F265I 265 F I 0.054 Neutral MSH6 P52701 F265K 265 F K 0.184 Neutral MSH6 P52701 F265L 265 F L 0.06 Neutral MSH6 P52701 F265M 265 F M 0.086 Neutral MSH6 P52701 F265N 265 F N 0.18 Neutral MSH6 P52701 F265P 265 F P 0.06 Neutral MSH6 P52701 F265Q 265 F Q 0.058 Neutral MSH6 P52701 F265R 265 F R 0.142 Neutral MSH6 P52701 F265S 265 F S 0.018 Neutral MSH6 P52701 F265T 265 F T 0.172 Neutral MSH6 P52701 F265V 265 F V 0.214 Neutral MSH6 P52701 F265W 265 F W 0.268 Neutral MSH6 P52701 F265Y 265 F Y 0.1 Neutral MSH6 P52701 K266A 266 K A 0.028 Neutral MSH6 P52701 K266C 266 K C 0.028 Neutral MSH6 P52701 K266D 266 K D 0.002 Neutral MSH6 P52701 K266E 266 K E 0.004 Neutral MSH6 P52701 K266F 266 K F 0.212 Neutral MSH6 P52701 K266G 266 K G 0.062 Neutral MSH6 P52701 K266H 266 K H 0.048 Neutral MSH6 P52701 K266I 266 K I 0.222 Neutral MSH6 P52701 K266L 266 K L 0.104 Neutral MSH6 P52701 K266M 266 K M 0.106 Neutral MSH6 P52701 K266N 266 K N 0.046 Neutral MSH6 P52701 K266P 266 K P 0.236 Neutral MSH6 P52701 K266Q 266 K Q 0.006 Neutral MSH6 P52701 K266R 266 K R 0.016 Neutral MSH6 P52701 K266S 266 K S 0.014 Neutral MSH6 P52701 K266T 266 K T 0.18 Neutral MSH6 P52701 K266V 266 K V 0.184 Neutral MSH6 P52701 K266W 266 K W 0.396 Neutral MSH6 P52701 K266Y 266 K Y 0.326 Neutral MSH6 P52701 P267A 267 P A 0.176 Neutral MSH6 P52701 P267C 267 P C 0.148 Neutral MSH6 P52701 P267D 267 P D 0.008 Neutral MSH6 P52701 P267E 267 P E 0.054 Neutral MSH6 P52701 P267F 267 P F 0.272 Neutral MSH6 P52701 P267G 267 P G 0.066 Neutral MSH6 P52701 P267H 267 P H 0.266 Neutral MSH6 P52701 P267I 267 P I 0.104 Neutral MSH6 P52701 P267K 267 P K 0.144 Neutral MSH6 P52701 P267L 267 P L 0.108 Neutral MSH6 P52701 P267M 267 P M 0.22 Neutral MSH6 P52701 P267N 267 P N 0.018 Neutral MSH6 P52701 P267Q 267 P Q 0.06 Neutral MSH6 P52701 P267R 267 P R 0.202 Neutral MSH6 P52701 P267S 267 P S 0.002 Neutral MSH6 P52701 P267T 267 P T 0.188 Neutral MSH6 P52701 P267V 267 P V 0.13 Neutral MSH6 P52701 P267W 267 P W 0.39 Neutral MSH6 P52701 P267Y 267 P Y 0.32 Neutral MSH6 P52701 D268A 268 D A 0.014 Neutral MSH6 P52701 D268C 268 D C 0.156 Neutral MSH6 P52701 D268E 268 D E 0.014 Neutral MSH6 P52701 D268F 268 D F 0.44 Neutral MSH6 P52701 D268G 268 D G 0.018 Neutral MSH6 P52701 D268H 268 D H 0.166 Neutral MSH6 P52701 D268I 268 D I 0.232 Neutral MSH6 P52701 D268K 268 D K 0.214 Neutral MSH6 P52701 D268L 268 D L 0.118 Neutral MSH6 P52701 D268M 268 D M 0.212 Neutral MSH6 P52701 D268N 268 D N 0.058 Neutral MSH6 P52701 D268P 268 D P 0.306 Neutral MSH6 P52701 D268Q 268 D Q 0.116 Neutral MSH6 P52701 D268R 268 D R 0.178 Neutral MSH6 P52701 D268S 268 D S 0.002 Neutral MSH6 P52701 D268T 268 D T 0.162 Neutral MSH6 P52701 D268V 268 D V 0.288 Neutral MSH6 P52701 D268W 268 D W 0.514 Pathogenic MSH6 P52701 D268Y 268 D Y 0.48 Neutral MSH6 P52701 T269A 269 T A 0 Neutral MSH6 P52701 T269C 269 T C 0.064 Neutral MSH6 P52701 T269D 269 T D 0.022 Neutral MSH6 P52701 T269E 269 T E 0.024 Neutral MSH6 P52701 T269F 269 T F 0.214 Neutral MSH6 P52701 T269G 269 T G 0.002 Neutral MSH6 P52701 T269H 269 T H 0.084 Neutral MSH6 P52701 T269I 269 T I 0.066 Neutral MSH6 P52701 T269K 269 T K 0.032 Neutral MSH6 P52701 T269L 269 T L 0.016 Neutral MSH6 P52701 T269M 269 T M 0.098 Neutral MSH6 P52701 T269N 269 T N 0.012 Neutral MSH6 P52701 T269P 269 T P 0.1 Neutral MSH6 P52701 T269Q 269 T Q 0.052 Neutral MSH6 P52701 T269R 269 T R 0.14 Neutral MSH6 P52701 T269S 269 T S 0 Neutral MSH6 P52701 T269V 269 T V 0.016 Neutral MSH6 P52701 T269W 269 T W 0.466 Neutral MSH6 P52701 T269Y 269 T Y 0.424 Neutral MSH6 P52701 A27C 27 A C 0.182 Neutral MSH6 P52701 A27D 27 A D 0.266 Neutral MSH6 P52701 A27E 27 A E 0.306 Neutral MSH6 P52701 A27F 27 A F 0.468 Neutral MSH6 P52701 A27G 27 A G 0.12 Neutral MSH6 P52701 A27H 27 A H 0.304 Neutral MSH6 P52701 A27I 27 A I 0.406 Neutral MSH6 P52701 A27K 27 A K 0.262 Neutral MSH6 P52701 A27L 27 A L 0.4 Neutral MSH6 P52701 A27M 27 A M 0.29 Neutral MSH6 P52701 A27N 27 A N 0.274 Neutral MSH6 P52701 A27P 27 A P 0.04 Neutral MSH6 P52701 A27Q 27 A Q 0.302 Neutral MSH6 P52701 A27R 27 A R 0.36 Neutral MSH6 P52701 A27S 27 A S 0.024 Neutral MSH6 P52701 A27T 27 A T 0.08 Neutral MSH6 P52701 A27V 27 A V 0.202 Neutral MSH6 P52701 A27W 27 A W 0.504 Pathogenic MSH6 P52701 A27Y 27 A Y 0.5 Pathogenic MSH6 P52701 K270A 270 K A 0.096 Neutral MSH6 P52701 K270C 270 K C 0.028 Neutral MSH6 P52701 K270D 270 K D 0.002 Neutral MSH6 P52701 K270E 270 K E 0.004 Neutral MSH6 P52701 K270F 270 K F 0.032 Neutral MSH6 P52701 K270G 270 K G 0.132 Neutral MSH6 P52701 K270H 270 K H 0.048 Neutral MSH6 P52701 K270I 270 K I 0.19 Neutral MSH6 P52701 K270L 270 K L 0.214 Neutral MSH6 P52701 K270M 270 K M 0.146 Neutral MSH6 P52701 K270N 270 K N 0.046 Neutral MSH6 P52701 K270P 270 K P 0.236 Neutral MSH6 P52701 K270Q 270 K Q 0.024 Neutral MSH6 P52701 K270R 270 K R 0.016 Neutral MSH6 P52701 K270S 270 K S 0.012 Neutral MSH6 P52701 K270T 270 K T 0.028 Neutral MSH6 P52701 K270V 270 K V 0.184 Neutral MSH6 P52701 K270W 270 K W 0.396 Neutral MSH6 P52701 K270Y 270 K Y 0.326 Neutral MSH6 P52701 E271A 271 E A 0.144 Neutral MSH6 P52701 E271C 271 E C 0.068 Neutral MSH6 P52701 E271D 271 E D 0 Neutral MSH6 P52701 E271F 271 E F 0.272 Neutral MSH6 P52701 E271G 271 E G 0.084 Neutral MSH6 P52701 E271H 271 E H 0.096 Neutral MSH6 P52701 E271I 271 E I 0.284 Neutral MSH6 P52701 E271K 271 E K 0.006 Neutral MSH6 P52701 E271L 271 E L 0.286 Neutral MSH6 P52701 E271M 271 E M 0.164 Neutral MSH6 P52701 E271N 271 E N 0.04 Neutral MSH6 P52701 E271P 271 E P 0.124 Neutral MSH6 P52701 E271Q 271 E Q 0 Neutral MSH6 P52701 E271R 271 E R 0.03 Neutral MSH6 P52701 E271S 271 E S 0.014 Neutral MSH6 P52701 E271T 271 E T 0.14 Neutral MSH6 P52701 E271V 271 E V 0.25 Neutral MSH6 P52701 E271W 271 E W 0.43 Neutral MSH6 P52701 E271Y 271 E Y 0.338 Neutral MSH6 P52701 E272A 272 E A 0.066 Neutral MSH6 P52701 E272C 272 E C 0.068 Neutral MSH6 P52701 E272D 272 E D 0 Neutral MSH6 P52701 E272F 272 E F 0.164 Neutral MSH6 P52701 E272G 272 E G 0 Neutral MSH6 P52701 E272H 272 E H 0.104 Neutral MSH6 P52701 E272I 272 E I 0.128 Neutral MSH6 P52701 E272K 272 E K 0.002 Neutral MSH6 P52701 E272L 272 E L 0.286 Neutral MSH6 P52701 E272M 272 E M 0.164 Neutral MSH6 P52701 E272N 272 E N 0.006 Neutral MSH6 P52701 E272P 272 E P 0.042 Neutral MSH6 P52701 E272Q 272 E Q 0.012 Neutral MSH6 P52701 E272R 272 E R 0.03 Neutral MSH6 P52701 E272S 272 E S 0.014 Neutral MSH6 P52701 E272T 272 E T 0.168 Neutral MSH6 P52701 E272V 272 E V 0.066 Neutral MSH6 P52701 E272W 272 E W 0.43 Neutral MSH6 P52701 E272Y 272 E Y 0.338 Neutral MSH6 P52701 G273A 273 G A 0.002 Neutral MSH6 P52701 G273C 273 G C 0.14 Neutral MSH6 P52701 G273D 273 G D 0.134 Neutral MSH6 P52701 G273E 273 G E 0.192 Neutral MSH6 P52701 G273F 273 G F 0.422 Neutral MSH6 P52701 G273H 273 G H 0.294 Neutral MSH6 P52701 G273I 273 G I 0.408 Neutral MSH6 P52701 G273K 273 G K 0.312 Neutral MSH6 P52701 G273L 273 G L 0.37 Neutral MSH6 P52701 G273M 273 G M 0.34 Neutral MSH6 P52701 G273N 273 G N 0.168 Neutral MSH6 P52701 G273P 273 G P 0.442 Neutral MSH6 P52701 G273Q 273 G Q 0.18 Neutral MSH6 P52701 G273R 273 G R 0.324 Neutral MSH6 P52701 G273S 273 G S 0.018 Neutral MSH6 P52701 G273T 273 G T 0.274 Neutral MSH6 P52701 G273V 273 G V 0.328 Neutral MSH6 P52701 G273W 273 G W 0.498 Neutral MSH6 P52701 G273Y 273 G Y 0.5 Pathogenic MSH6 P52701 S274A 274 S A 0.052 Neutral MSH6 P52701 S274C 274 S C 0.032 Neutral MSH6 P52701 S274D 274 S D 0.002 Neutral MSH6 P52701 S274E 274 S E 0.142 Neutral MSH6 P52701 S274F 274 S F 0.27 Neutral MSH6 P52701 S274G 274 S G 0.036 Neutral MSH6 P52701 S274H 274 S H 0.242 Neutral MSH6 P52701 S274I 274 S I 0.196 Neutral MSH6 P52701 S274K 274 S K 0.146 Neutral MSH6 P52701 S274L 274 S L 0.028 Neutral MSH6 P52701 S274M 274 S M 0.28 Neutral MSH6 P52701 S274N 274 S N 0 Neutral MSH6 P52701 S274P 274 S P 0.066 Neutral MSH6 P52701 S274Q 274 S Q 0.162 Neutral MSH6 P52701 S274R 274 S R 0.154 Neutral MSH6 P52701 S274T 274 S T 0.112 Neutral MSH6 P52701 S274V 274 S V 0.138 Neutral MSH6 P52701 S274W 274 S W 0.502 Pathogenic MSH6 P52701 S274Y 274 S Y 0.398 Neutral MSH6 P52701 S275A 275 S A 0.068 Neutral MSH6 P52701 S275C 275 S C 0.032 Neutral MSH6 P52701 S275D 275 S D 0.004 Neutral MSH6 P52701 S275E 275 S E 0.148 Neutral MSH6 P52701 S275F 275 S F 0.276 Neutral MSH6 P52701 S275G 275 S G 0.01 Neutral MSH6 P52701 S275H 275 S H 0.258 Neutral MSH6 P52701 S275I 275 S I 0.126 Neutral MSH6 P52701 S275K 275 S K 0.158 Neutral MSH6 P52701 S275L 275 S L 0.042 Neutral MSH6 P52701 S275M 275 S M 0.374 Neutral MSH6 P52701 S275N 275 S N 0 Neutral MSH6 P52701 S275P 275 S P 0.132 Neutral MSH6 P52701 S275Q 275 S Q 0.172 Neutral MSH6 P52701 S275R 275 S R 0.194 Neutral MSH6 P52701 S275T 275 S T 0.178 Neutral MSH6 P52701 S275V 275 S V 0.072 Neutral MSH6 P52701 S275W 275 S W 0.51 Pathogenic MSH6 P52701 S275Y 275 S Y 0.48 Neutral MSH6 P52701 D276A 276 D A 0.016 Neutral MSH6 P52701 D276C 276 D C 0.192 Neutral MSH6 P52701 D276E 276 D E 0.016 Neutral MSH6 P52701 D276F 276 D F 0.544 Pathogenic MSH6 P52701 D276G 276 D G 0.022 Neutral MSH6 P52701 D276H 276 D H 0.122 Neutral MSH6 P52701 D276I 276 D I 0.35 Neutral MSH6 P52701 D276K 276 D K 0.06 Neutral MSH6 P52701 D276L 276 D L 0.344 Neutral MSH6 P52701 D276M 276 D M 0.262 Neutral MSH6 P52701 D276N 276 D N 0.002 Neutral MSH6 P52701 D276P 276 D P 0.174 Neutral MSH6 P52701 D276Q 276 D Q 0.14 Neutral MSH6 P52701 D276R 276 D R 0.298 Neutral MSH6 P52701 D276S 276 D S 0.004 Neutral MSH6 P52701 D276T 276 D T 0.146 Neutral MSH6 P52701 D276V 276 D V 0.218 Neutral MSH6 P52701 D276W 276 D W 0.62 Pathogenic MSH6 P52701 D276Y 276 D Y 0.59 Pathogenic MSH6 P52701 E277A 277 E A 0.066 Neutral MSH6 P52701 E277C 277 E C 0.068 Neutral MSH6 P52701 E277D 277 E D 0 Neutral MSH6 P52701 E277F 277 E F 0.296 Neutral MSH6 P52701 E277G 277 E G 0.004 Neutral MSH6 P52701 E277H 277 E H 0.108 Neutral MSH6 P52701 E277I 277 E I 0.31 Neutral MSH6 P52701 E277K 277 E K 0.068 Neutral MSH6 P52701 E277L 277 E L 0.308 Neutral MSH6 P52701 E277M 277 E M 0.176 Neutral MSH6 P52701 E277N 277 E N 0.002 Neutral MSH6 P52701 E277P 277 E P 0.322 Neutral MSH6 P52701 E277Q 277 E Q 0.056 Neutral MSH6 P52701 E277R 277 E R 0.036 Neutral MSH6 P52701 E277S 277 E S 0.014 Neutral MSH6 P52701 E277T 277 E T 0.008 Neutral MSH6 P52701 E277V 277 E V 0.272 Neutral MSH6 P52701 E277W 277 E W 0.508 Pathogenic MSH6 P52701 E277Y 277 E Y 0.258 Neutral MSH6 P52701 I278A 278 I A 0.006 Neutral MSH6 P52701 I278C 278 I C 0.09 Neutral MSH6 P52701 I278D 278 I D 0.088 Neutral MSH6 P52701 I278E 278 I E 0.032 Neutral MSH6 P52701 I278F 278 I F 0.206 Neutral MSH6 P52701 I278G 278 I G 0.108 Neutral MSH6 P52701 I278H 278 I H 0.08 Neutral MSH6 P52701 I278K 278 I K 0.166 Neutral MSH6 P52701 I278L 278 I L 0.15 Neutral MSH6 P52701 I278M 278 I M 0.02 Neutral MSH6 P52701 I278N 278 I N 0.112 Neutral MSH6 P52701 I278P 278 I P 0.186 Neutral MSH6 P52701 I278Q 278 I Q 0.174 Neutral MSH6 P52701 I278R 278 I R 0.26 Neutral MSH6 P52701 I278S 278 I S 0.072 Neutral MSH6 P52701 I278T 278 I T 0.192 Neutral MSH6 P52701 I278V 278 I V 0.002 Neutral MSH6 P52701 I278W 278 I W 0.344 Neutral MSH6 P52701 I278Y 278 I Y 0.32 Neutral MSH6 P52701 S279A 279 S A 0.018 Neutral MSH6 P52701 S279C 279 S C 0.032 Neutral MSH6 P52701 S279D 279 S D 0.002 Neutral MSH6 P52701 S279E 279 S E 0.146 Neutral MSH6 P52701 S279F 279 S F 0.308 Neutral MSH6 P52701 S279G 279 S G 0.064 Neutral MSH6 P52701 S279H 279 S H 0.292 Neutral MSH6 P52701 S279I 279 S I 0.144 Neutral MSH6 P52701 S279K 279 S K 0.182 Neutral MSH6 P52701 S279L 279 S L 0.088 Neutral MSH6 P52701 S279M 279 S M 0.322 Neutral MSH6 P52701 S279N 279 S N 0.004 Neutral MSH6 P52701 S279P 279 S P 0.146 Neutral MSH6 P52701 S279Q 279 S Q 0.182 Neutral MSH6 P52701 S279R 279 S R 0.304 Neutral MSH6 P52701 S279T 279 S T 0.18 Neutral MSH6 P52701 S279V 279 S V 0.304 Neutral MSH6 P52701 S279W 279 S W 0.56 Pathogenic MSH6 P52701 S279Y 279 S Y 0.518 Pathogenic MSH6 P52701 S28A 28 S A 0.018 Neutral MSH6 P52701 S28C 28 S C 0.032 Neutral MSH6 P52701 S28D 28 S D 0.044 Neutral MSH6 P52701 S28E 28 S E 0.148 Neutral MSH6 P52701 S28F 28 S F 0.276 Neutral MSH6 P52701 S28G 28 S G 0.064 Neutral MSH6 P52701 S28H 28 S H 0.238 Neutral MSH6 P52701 S28I 28 S I 0.026 Neutral MSH6 P52701 S28K 28 S K 0.164 Neutral MSH6 P52701 S28L 28 S L 0.068 Neutral MSH6 P52701 S28M 28 S M 0.332 Neutral MSH6 P52701 S28N 28 S N 0.034 Neutral MSH6 P52701 S28P 28 S P 0.116 Neutral MSH6 P52701 S28Q 28 S Q 0.132 Neutral MSH6 P52701 S28R 28 S R 0.248 Neutral MSH6 P52701 S28T 28 S T 0.176 Neutral MSH6 P52701 S28V 28 S V 0.248 Neutral MSH6 P52701 S28W 28 S W 0.49 Neutral MSH6 P52701 S28Y 28 S Y 0.448 Neutral MSH6 P52701 S280A 280 S A 0.068 Neutral MSH6 P52701 S280C 280 S C 0.032 Neutral MSH6 P52701 S280D 280 S D 0.004 Neutral MSH6 P52701 S280E 280 S E 0.156 Neutral MSH6 P52701 S280F 280 S F 0.32 Neutral MSH6 P52701 S280G 280 S G 0.036 Neutral MSH6 P52701 S280H 280 S H 0.276 Neutral MSH6 P52701 S280I 280 S I 0.036 Neutral MSH6 P52701 S280K 280 S K 0.184 Neutral MSH6 P52701 S280L 280 S L 0.086 Neutral MSH6 P52701 S280M 280 S M 0.4 Neutral MSH6 P52701 S280N 280 S N 0.016 Neutral MSH6 P52701 S280P 280 S P 0.074 Neutral MSH6 P52701 S280Q 280 S Q 0.192 Neutral MSH6 P52701 S280R 280 S R 0.156 Neutral MSH6 P52701 S280T 280 S T 0.02 Neutral MSH6 P52701 S280V 280 S V 0.302 Neutral MSH6 P52701 S280W 280 S W 0.542 Pathogenic MSH6 P52701 S280Y 280 S Y 0.498 Neutral MSH6 P52701 G281A 281 G A 0.018 Neutral MSH6 P52701 G281C 281 G C 0.14 Neutral MSH6 P52701 G281D 281 G D 0.136 Neutral MSH6 P52701 G281E 281 G E 0.198 Neutral MSH6 P52701 G281F 281 G F 0.478 Neutral MSH6 P52701 G281H 281 G H 0.442 Neutral MSH6 P52701 G281I 281 G I 0.412 Neutral MSH6 P52701 G281K 281 G K 0.27 Neutral MSH6 P52701 G281L 281 G L 0.412 Neutral MSH6 P52701 G281M 281 G M 0.34 Neutral MSH6 P52701 G281N 281 G N 0.162 Neutral MSH6 P52701 G281P 281 G P 0.35 Neutral MSH6 P52701 G281Q 281 G Q 0.262 Neutral MSH6 P52701 G281R 281 G R 0.3 Neutral MSH6 P52701 G281S 281 G S 0.018 Neutral MSH6 P52701 G281T 281 G T 0.284 Neutral MSH6 P52701 G281V 281 G V 0.344 Neutral MSH6 P52701 G281W 281 G W 0.498 Neutral MSH6 P52701 G281Y 281 G Y 0.456 Neutral MSH6 P52701 V282A 282 V A 0 Neutral MSH6 P52701 V282C 282 V C 0.058 Neutral MSH6 P52701 V282D 282 V D 0.026 Neutral MSH6 P52701 V282E 282 V E 0.042 Neutral MSH6 P52701 V282F 282 V F 0.172 Neutral MSH6 P52701 V282G 282 V G 0.054 Neutral MSH6 P52701 V282H 282 V H 0.112 Neutral MSH6 P52701 V282I 282 V I 0.002 Neutral MSH6 P52701 V282K 282 V K 0.062 Neutral MSH6 P52701 V282L 282 V L 0 Neutral MSH6 P52701 V282M 282 V M 0.014 Neutral MSH6 P52701 V282N 282 V N 0.088 Neutral MSH6 P52701 V282P 282 V P 0.142 Neutral MSH6 P52701 V282Q 282 V Q 0.158 Neutral MSH6 P52701 V282R 282 V R 0.208 Neutral MSH6 P52701 V282S 282 V S 0.01 Neutral MSH6 P52701 V282T 282 V T 0.03 Neutral MSH6 P52701 V282W 282 V W 0.344 Neutral MSH6 P52701 V282Y 282 V Y 0.162 Neutral MSH6 P52701 G283A 283 G A 0.01 Neutral MSH6 P52701 G283C 283 G C 0.162 Neutral MSH6 P52701 G283D 283 G D 0.134 Neutral MSH6 P52701 G283E 283 G E 0.192 Neutral MSH6 P52701 G283F 283 G F 0.422 Neutral MSH6 P52701 G283H 283 G H 0.37 Neutral MSH6 P52701 G283I 283 G I 0.416 Neutral MSH6 P52701 G283K 283 G K 0.272 Neutral MSH6 P52701 G283L 283 G L 0.412 Neutral MSH6 P52701 G283M 283 G M 0.422 Neutral MSH6 P52701 G283N 283 G N 0.162 Neutral MSH6 P52701 G283P 283 G P 0.442 Neutral MSH6 P52701 G283Q 283 G Q 0.18 Neutral MSH6 P52701 G283R 283 G R 0.362 Neutral MSH6 P52701 G283S 283 G S 0.016 Neutral MSH6 P52701 G283T 283 G T 0.252 Neutral MSH6 P52701 G283V 283 G V 0.394 Neutral MSH6 P52701 G283W 283 G W 0.498 Neutral MSH6 P52701 G283Y 283 G Y 0.5 Pathogenic MSH6 P52701 D284A 284 D A 0.028 Neutral MSH6 P52701 D284C 284 D C 0.17 Neutral MSH6 P52701 D284E 284 D E 0.014 Neutral MSH6 P52701 D284F 284 D F 0.406 Neutral MSH6 P52701 D284G 284 D G 0.018 Neutral MSH6 P52701 D284H 284 D H 0.154 Neutral MSH6 P52701 D284I 284 D I 0.262 Neutral MSH6 P52701 D284K 284 D K 0.112 Neutral MSH6 P52701 D284L 284 D L 0.054 Neutral MSH6 P52701 D284M 284 D M 0.19 Neutral MSH6 P52701 D284N 284 D N 0.012 Neutral MSH6 P52701 D284P 284 D P 0.066 Neutral MSH6 P52701 D284Q 284 D Q 0.112 Neutral MSH6 P52701 D284R 284 D R 0.152 Neutral MSH6 P52701 D284S 284 D S 0.002 Neutral MSH6 P52701 D284T 284 D T 0.016 Neutral MSH6 P52701 D284V 284 D V 0.07 Neutral MSH6 P52701 D284W 284 D W 0.434 Neutral MSH6 P52701 D284Y 284 D Y 0.404 Neutral MSH6 P52701 S285A 285 S A 0.01 Neutral MSH6 P52701 S285C 285 S C 0.032 Neutral MSH6 P52701 S285D 285 S D 0.002 Neutral MSH6 P52701 S285E 285 S E 0.14 Neutral MSH6 P52701 S285F 285 S F 0.266 Neutral MSH6 P52701 S285G 285 S G 0 Neutral MSH6 P52701 S285H 285 S H 0.238 Neutral MSH6 P52701 S285I 285 S I 0.196 Neutral MSH6 P52701 S285K 285 S K 0.162 Neutral MSH6 P52701 S285L 285 S L 0.028 Neutral MSH6 P52701 S285M 285 S M 0.28 Neutral MSH6 P52701 S285N 285 S N 0 Neutral MSH6 P52701 S285P 285 S P 0.098 Neutral MSH6 P52701 S285Q 285 S Q 0.16 Neutral MSH6 P52701 S285R 285 S R 0.136 Neutral MSH6 P52701 S285T 285 S T 0.02 Neutral MSH6 P52701 S285V 285 S V 0.134 Neutral MSH6 P52701 S285W 285 S W 0.472 Neutral MSH6 P52701 S285Y 285 S Y 0.448 Neutral MSH6 P52701 E286A 286 E A 0.118 Neutral MSH6 P52701 E286C 286 E C 0.068 Neutral MSH6 P52701 E286D 286 E D 0 Neutral MSH6 P52701 E286F 286 E F 0.28 Neutral MSH6 P52701 E286G 286 E G 0.002 Neutral MSH6 P52701 E286H 286 E H 0.164 Neutral MSH6 P52701 E286I 286 E I 0.292 Neutral MSH6 P52701 E286K 286 E K 0.002 Neutral MSH6 P52701 E286L 286 E L 0.294 Neutral MSH6 P52701 E286M 286 E M 0.172 Neutral MSH6 P52701 E286N 286 E N 0.056 Neutral MSH6 P52701 E286P 286 E P 0.066 Neutral MSH6 P52701 E286Q 286 E Q 0 Neutral MSH6 P52701 E286R 286 E R 0.032 Neutral MSH6 P52701 E286S 286 E S 0.014 Neutral MSH6 P52701 E286T 286 E T 0.008 Neutral MSH6 P52701 E286V 286 E V 0.068 Neutral MSH6 P52701 E286W 286 E W 0.448 Neutral MSH6 P52701 E286Y 286 E Y 0.356 Neutral MSH6 P52701 S287A 287 S A 0.01 Neutral MSH6 P52701 S287C 287 S C 0.008 Neutral MSH6 P52701 S287D 287 S D 0.002 Neutral MSH6 P52701 S287E 287 S E 0.138 Neutral MSH6 P52701 S287F 287 S F 0.276 Neutral MSH6 P52701 S287G 287 S G 0 Neutral MSH6 P52701 S287H 287 S H 0.238 Neutral MSH6 P52701 S287I 287 S I 0.196 Neutral MSH6 P52701 S287K 287 S K 0.148 Neutral MSH6 P52701 S287L 287 S L 0.032 Neutral MSH6 P52701 S287M 287 S M 0.332 Neutral MSH6 P52701 S287N 287 S N 0 Neutral MSH6 P52701 S287P 287 S P 0.066 Neutral MSH6 P52701 S287Q 287 S Q 0.132 Neutral MSH6 P52701 S287R 287 S R 0.17 Neutral MSH6 P52701 S287T 287 S T 0.02 Neutral MSH6 P52701 S287V 287 S V 0.032 Neutral MSH6 P52701 S287W 287 S W 0.49 Neutral MSH6 P52701 S287Y 287 S Y 0.434 Neutral MSH6 P52701 E288A 288 E A 0.066 Neutral MSH6 P52701 E288C 288 E C 0.064 Neutral MSH6 P52701 E288D 288 E D 0 Neutral MSH6 P52701 E288F 288 E F 0.272 Neutral MSH6 P52701 E288G 288 E G 0.084 Neutral MSH6 P52701 E288H 288 E H 0.162 Neutral MSH6 P52701 E288I 288 E I 0.322 Neutral MSH6 P52701 E288K 288 E K 0.002 Neutral MSH6 P52701 E288L 288 E L 0.286 Neutral MSH6 P52701 E288M 288 E M 0.166 Neutral MSH6 P52701 E288N 288 E N 0.056 Neutral MSH6 P52701 E288P 288 E P 0.282 Neutral MSH6 P52701 E288Q 288 E Q 0.018 Neutral MSH6 P52701 E288R 288 E R 0.016 Neutral MSH6 P52701 E288S 288 E S 0.014 Neutral MSH6 P52701 E288T 288 E T 0.006 Neutral MSH6 P52701 E288V 288 E V 0.066 Neutral MSH6 P52701 E288W 288 E W 0.43 Neutral MSH6 P52701 E288Y 288 E Y 0.338 Neutral MSH6 P52701 G289A 289 G A 0.008 Neutral MSH6 P52701 G289C 289 G C 0.14 Neutral MSH6 P52701 G289D 289 G D 0.138 Neutral MSH6 P52701 G289E 289 G E 0.19 Neutral MSH6 P52701 G289F 289 G F 0.388 Neutral MSH6 P52701 G289H 289 G H 0.442 Neutral MSH6 P52701 G289I 289 G I 0.428 Neutral MSH6 P52701 G289K 289 G K 0.286 Neutral MSH6 P52701 G289L 289 G L 0.37 Neutral MSH6 P52701 G289M 289 G M 0.422 Neutral MSH6 P52701 G289N 289 G N 0.172 Neutral MSH6 P52701 G289P 289 G P 0.442 Neutral MSH6 P52701 G289Q 289 G Q 0.262 Neutral MSH6 P52701 G289R 289 G R 0.362 Neutral MSH6 P52701 G289S 289 G S 0.016 Neutral MSH6 P52701 G289T 289 G T 0.252 Neutral MSH6 P52701 G289V 289 G V 0.344 Neutral MSH6 P52701 G289W 289 G W 0.498 Neutral MSH6 P52701 G289Y 289 G Y 0.5 Pathogenic MSH6 P52701 R29A 29 R A 0.126 Neutral MSH6 P52701 R29C 29 R C 0.14 Neutral MSH6 P52701 R29D 29 R D 0.18 Neutral MSH6 P52701 R29E 29 R E 0.128 Neutral MSH6 P52701 R29F 29 R F 0.28 Neutral MSH6 P52701 R29G 29 R G 0.038 Neutral MSH6 P52701 R29H 29 R H 0.12 Neutral MSH6 P52701 R29I 29 R I 0.304 Neutral MSH6 P52701 R29K 29 R K 0.172 Neutral MSH6 P52701 R29L 29 R L 0.272 Neutral MSH6 P52701 R29M 29 R M 0.164 Neutral MSH6 P52701 R29N 29 R N 0.176 Neutral MSH6 P52701 R29P 29 R P 0.106 Neutral MSH6 P52701 R29Q 29 R Q 0.16 Neutral MSH6 P52701 R29S 29 R S 0.016 Neutral MSH6 P52701 R29T 29 R T 0.142 Neutral MSH6 P52701 R29V 29 R V 0.242 Neutral MSH6 P52701 R29W 29 R W 0.384 Neutral MSH6 P52701 R29Y 29 R Y 0.284 Neutral MSH6 P52701 L290A 290 L A 0.064 Neutral MSH6 P52701 L290C 290 L C 0.094 Neutral MSH6 P52701 L290D 290 L D 0.04 Neutral MSH6 P52701 L290E 290 L E 0.03 Neutral MSH6 P52701 L290F 290 L F 0.242 Neutral MSH6 P52701 L290G 290 L G 0.08 Neutral MSH6 P52701 L290H 290 L H 0.084 Neutral MSH6 P52701 L290I 290 L I 0.072 Neutral MSH6 P52701 L290K 290 L K 0.084 Neutral MSH6 P52701 L290M 290 L M 0.08 Neutral MSH6 P52701 L290N 290 L N 0.138 Neutral MSH6 P52701 L290P 290 L P 0.086 Neutral MSH6 P52701 L290Q 290 L Q 0.064 Neutral MSH6 P52701 L290R 290 L R 0.234 Neutral MSH6 P52701 L290S 290 L S 0.014 Neutral MSH6 P52701 L290T 290 L T 0.01 Neutral MSH6 P52701 L290V 290 L V 0 Neutral MSH6 P52701 L290W 290 L W 0.334 Neutral MSH6 P52701 L290Y 290 L Y 0.284 Neutral MSH6 P52701 N291A 291 N A 0.014 Neutral MSH6 P52701 N291C 291 N C 0.148 Neutral MSH6 P52701 N291D 291 N D 0.006 Neutral MSH6 P52701 N291E 291 N E 0.012 Neutral MSH6 P52701 N291F 291 N F 0.34 Neutral MSH6 P52701 N291G 291 N G 0.02 Neutral MSH6 P52701 N291H 291 N H 0.262 Neutral MSH6 P52701 N291I 291 N I 0.266 Neutral MSH6 P52701 N291K 291 N K 0.148 Neutral MSH6 P52701 N291L 291 N L 0.314 Neutral MSH6 P52701 N291M 291 N M 0.22 Neutral MSH6 P52701 N291P 291 N P 0.158 Neutral MSH6 P52701 N291Q 291 N Q 0.166 Neutral MSH6 P52701 N291R 291 N R 0.148 Neutral MSH6 P52701 N291S 291 N S 0 Neutral MSH6 P52701 N291T 291 N T 0.142 Neutral MSH6 P52701 N291V 291 N V 0.28 Neutral MSH6 P52701 N291W 291 N W 0.446 Neutral MSH6 P52701 N291Y 291 N Y 0.414 Neutral MSH6 P52701 S292A 292 S A 0.052 Neutral MSH6 P52701 S292C 292 S C 0.022 Neutral MSH6 P52701 S292D 292 S D 0.002 Neutral MSH6 P52701 S292E 292 S E 0.138 Neutral MSH6 P52701 S292F 292 S F 0.276 Neutral MSH6 P52701 S292G 292 S G 0.036 Neutral MSH6 P52701 S292H 292 S H 0.176 Neutral MSH6 P52701 S292I 292 S I 0.026 Neutral MSH6 P52701 S292K 292 S K 0.14 Neutral MSH6 P52701 S292L 292 S L 0.068 Neutral MSH6 P52701 S292M 292 S M 0.28 Neutral MSH6 P52701 S292N 292 S N 0.034 Neutral MSH6 P52701 S292P 292 S P 0.062 Neutral MSH6 P52701 S292Q 292 S Q 0.158 Neutral MSH6 P52701 S292R 292 S R 0.136 Neutral MSH6 P52701 S292T 292 S T 0.02 Neutral MSH6 P52701 S292V 292 S V 0.032 Neutral MSH6 P52701 S292W 292 S W 0.49 Neutral MSH6 P52701 S292Y 292 S Y 0.448 Neutral MSH6 P52701 P293A 293 P A 0.176 Neutral MSH6 P52701 P293C 293 P C 0.148 Neutral MSH6 P52701 P293D 293 P D 0.008 Neutral MSH6 P52701 P293E 293 P E 0.054 Neutral MSH6 P52701 P293F 293 P F 0.268 Neutral MSH6 P52701 P293G 293 P G 0.024 Neutral MSH6 P52701 P293H 293 P H 0.266 Neutral MSH6 P52701 P293I 293 P I 0.088 Neutral MSH6 P52701 P293K 293 P K 0.1 Neutral MSH6 P52701 P293L 293 P L 0.108 Neutral MSH6 P52701 P293M 293 P M 0.22 Neutral MSH6 P52701 P293N 293 P N 0.068 Neutral MSH6 P52701 P293Q 293 P Q 0.212 Neutral MSH6 P52701 P293R 293 P R 0.214 Neutral MSH6 P52701 P293S 293 P S 0.002 Neutral MSH6 P52701 P293T 293 P T 0.084 Neutral MSH6 P52701 P293V 293 P V 0.184 Neutral MSH6 P52701 P293W 293 P W 0.39 Neutral MSH6 P52701 P293Y 293 P Y 0.27 Neutral MSH6 P52701 V294A 294 V A 0 Neutral MSH6 P52701 V294C 294 V C 0.058 Neutral MSH6 P52701 V294D 294 V D 0.122 Neutral MSH6 P52701 V294E 294 V E 0.042 Neutral MSH6 P52701 V294F 294 V F 0.15 Neutral MSH6 P52701 V294G 294 V G 0.04 Neutral MSH6 P52701 V294H 294 V H 0.112 Neutral MSH6 P52701 V294I 294 V I 0.002 Neutral MSH6 P52701 V294K 294 V K 0.138 Neutral MSH6 P52701 V294L 294 V L 0.018 Neutral MSH6 P52701 V294M 294 V M 0.03 Neutral MSH6 P52701 V294N 294 V N 0.088 Neutral MSH6 P52701 V294P 294 V P 0.04 Neutral MSH6 P52701 V294Q 294 V Q 0.216 Neutral MSH6 P52701 V294R 294 V R 0.274 Neutral MSH6 P52701 V294S 294 V S 0.01 Neutral MSH6 P52701 V294T 294 V T 0.008 Neutral MSH6 P52701 V294W 294 V W 0.344 Neutral MSH6 P52701 V294Y 294 V Y 0.256 Neutral MSH6 P52701 K295A 295 K A 0.054 Neutral MSH6 P52701 K295C 295 K C 0.028 Neutral MSH6 P52701 K295D 295 K D 0.002 Neutral MSH6 P52701 K295E 295 K E 0.004 Neutral MSH6 P52701 K295F 295 K F 0.212 Neutral MSH6 P52701 K295G 295 K G 0.062 Neutral MSH6 P52701 K295H 295 K H 0.048 Neutral MSH6 P52701 K295I 295 K I 0.222 Neutral MSH6 P52701 K295L 295 K L 0.148 Neutral MSH6 P52701 K295M 295 K M 0.106 Neutral MSH6 P52701 K295N 295 K N 0.05 Neutral MSH6 P52701 K295P 295 K P 0.214 Neutral MSH6 P52701 K295Q 295 K Q 0.048 Neutral MSH6 P52701 K295R 295 K R 0.002 Neutral MSH6 P52701 K295S 295 K S 0.014 Neutral MSH6 P52701 K295T 295 K T 0.18 Neutral MSH6 P52701 K295V 295 K V 0.026 Neutral MSH6 P52701 K295W 295 K W 0.396 Neutral MSH6 P52701 K295Y 295 K Y 0.324 Neutral MSH6 P52701 V296A 296 V A 0 Neutral MSH6 P52701 V296C 296 V C 0.058 Neutral MSH6 P52701 V296D 296 V D 0.034 Neutral MSH6 P52701 V296E 296 V E 0.042 Neutral MSH6 P52701 V296F 296 V F 0.142 Neutral MSH6 P52701 V296G 296 V G 0.04 Neutral MSH6 P52701 V296H 296 V H 0.068 Neutral MSH6 P52701 V296I 296 V I 0.028 Neutral MSH6 P52701 V296K 296 V K 0.06 Neutral MSH6 P52701 V296L 296 V L 0.054 Neutral MSH6 P52701 V296M 296 V M 0.03 Neutral MSH6 P52701 V296N 296 V N 0.088 Neutral MSH6 P52701 V296P 296 V P 0.036 Neutral MSH6 P52701 V296Q 296 V Q 0.06 Neutral MSH6 P52701 V296R 296 V R 0.228 Neutral MSH6 P52701 V296S 296 V S 0.01 Neutral MSH6 P52701 V296T 296 V T 0.03 Neutral MSH6 P52701 V296W 296 V W 0.344 Neutral MSH6 P52701 V296Y 296 V Y 0.256 Neutral MSH6 P52701 A297C 297 A C 0.182 Neutral MSH6 P52701 A297D 297 A D 0.342 Neutral MSH6 P52701 A297E 297 A E 0.288 Neutral MSH6 P52701 A297F 297 A F 0.468 Neutral MSH6 P52701 A297G 297 A G 0.154 Neutral MSH6 P52701 A297H 297 A H 0.304 Neutral MSH6 P52701 A297I 297 A I 0.334 Neutral MSH6 P52701 A297K 297 A K 0.276 Neutral MSH6 P52701 A297L 297 A L 0.414 Neutral MSH6 P52701 A297M 297 A M 0.29 Neutral MSH6 P52701 A297N 297 A N 0.296 Neutral MSH6 P52701 A297P 297 A P 0.138 Neutral MSH6 P52701 A297Q 297 A Q 0.302 Neutral MSH6 P52701 A297R 297 A R 0.326 Neutral MSH6 P52701 A297S 297 A S 0.008 Neutral MSH6 P52701 A297T 297 A T 0.014 Neutral MSH6 P52701 A297V 297 A V 0.042 Neutral MSH6 P52701 A297W 297 A W 0.484 Neutral MSH6 P52701 A297Y 297 A Y 0.5 Pathogenic MSH6 P52701 R298A 298 R A 0.036 Neutral MSH6 P52701 R298C 298 R C 0.148 Neutral MSH6 P52701 R298D 298 R D 0.18 Neutral MSH6 P52701 R298E 298 R E 0.03 Neutral MSH6 P52701 R298F 298 R F 0.28 Neutral MSH6 P52701 R298G 298 R G 0.072 Neutral MSH6 P52701 R298H 298 R H 0.12 Neutral MSH6 P52701 R298I 298 R I 0.304 Neutral MSH6 P52701 R298K 298 R K 0.004 Neutral MSH6 P52701 R298L 298 R L 0.23 Neutral MSH6 P52701 R298M 298 R M 0.164 Neutral MSH6 P52701 R298N 298 R N 0.016 Neutral MSH6 P52701 R298P 298 R P 0.028 Neutral MSH6 P52701 R298Q 298 R Q 0.25 Neutral MSH6 P52701 R298S 298 R S 0.02 Neutral MSH6 P52701 R298T 298 R T 0.026 Neutral MSH6 P52701 R298V 298 R V 0.094 Neutral MSH6 P52701 R298W 298 R W 0.448 Neutral MSH6 P52701 R298Y 298 R Y 0.284 Neutral MSH6 P52701 K299A 299 K A 0.054 Neutral MSH6 P52701 K299C 299 K C 0.028 Neutral MSH6 P52701 K299D 299 K D 0.002 Neutral MSH6 P52701 K299E 299 K E 0.004 Neutral MSH6 P52701 K299F 299 K F 0.234 Neutral MSH6 P52701 K299G 299 K G 0.134 Neutral MSH6 P52701 K299H 299 K H 0.048 Neutral MSH6 P52701 K299I 299 K I 0.248 Neutral MSH6 P52701 K299L 299 K L 0.114 Neutral MSH6 P52701 K299M 299 K M 0.154 Neutral MSH6 P52701 K299N 299 K N 0.046 Neutral MSH6 P52701 K299P 299 K P 0.016 Neutral MSH6 P52701 K299Q 299 K Q 0.09 Neutral MSH6 P52701 K299R 299 K R 0.016 Neutral MSH6 P52701 K299S 299 K S 0.012 Neutral MSH6 P52701 K299T 299 K T 0.028 Neutral MSH6 P52701 K299V 299 K V 0.192 Neutral MSH6 P52701 K299W 299 K W 0.474 Neutral MSH6 P52701 K299Y 299 K Y 0.39 Neutral MSH6 P52701 R3A 3 R A 0.086 Neutral MSH6 P52701 R3C 3 R C 0.148 Neutral MSH6 P52701 R3D 3 R D 0.18 Neutral MSH6 P52701 R3E 3 R E 0.128 Neutral MSH6 P52701 R3F 3 R F 0.28 Neutral MSH6 P52701 R3G 3 R G 0.072 Neutral MSH6 P52701 R3H 3 R H 0.12 Neutral MSH6 P52701 R3I 3 R I 0.304 Neutral MSH6 P52701 R3K 3 R K 0.008 Neutral MSH6 P52701 R3L 3 R L 0.272 Neutral MSH6 P52701 R3M 3 R M 0.164 Neutral MSH6 P52701 R3N 3 R N 0.176 Neutral MSH6 P52701 R3P 3 R P 0.262 Neutral MSH6 P52701 R3Q 3 R Q 0.25 Neutral MSH6 P52701 R3S 3 R S 0.142 Neutral MSH6 P52701 R3T 3 R T 0.142 Neutral MSH6 P52701 R3V 3 R V 0.242 Neutral MSH6 P52701 R3W 3 R W 0.384 Neutral MSH6 P52701 R3Y 3 R Y 0.284 Neutral MSH6 P52701 E30A 30 E A 0.144 Neutral MSH6 P52701 E30C 30 E C 0.068 Neutral MSH6 P52701 E30D 30 E D 0.048 Neutral MSH6 P52701 E30F 30 E F 0.272 Neutral MSH6 P52701 E30G 30 E G 0.002 Neutral MSH6 P52701 E30H 30 E H 0.104 Neutral MSH6 P52701 E30I 30 E I 0.284 Neutral MSH6 P52701 E30K 30 E K 0.162 Neutral MSH6 P52701 E30L 30 E L 0.286 Neutral MSH6 P52701 E30M 30 E M 0.164 Neutral MSH6 P52701 E30N 30 E N 0.056 Neutral MSH6 P52701 E30P 30 E P 0.042 Neutral MSH6 P52701 E30Q 30 E Q 0.018 Neutral MSH6 P52701 E30R 30 E R 0.046 Neutral MSH6 P52701 E30S 30 E S 0.014 Neutral MSH6 P52701 E30T 30 E T 0.14 Neutral MSH6 P52701 E30V 30 E V 0.25 Neutral MSH6 P52701 E30W 30 E W 0.43 Neutral MSH6 P52701 E30Y 30 E Y 0.338 Neutral MSH6 P52701 R300A 300 R A 0.126 Neutral MSH6 P52701 R300C 300 R C 0.154 Neutral MSH6 P52701 R300D 300 R D 0.182 Neutral MSH6 P52701 R300E 300 R E 0.088 Neutral MSH6 P52701 R300F 300 R F 0.138 Neutral MSH6 P52701 R300G 300 R G 0.038 Neutral MSH6 P52701 R300H 300 R H 0.122 Neutral MSH6 P52701 R300I 300 R I 0.312 Neutral MSH6 P52701 R300K 300 R K 0.004 Neutral MSH6 P52701 R300L 300 R L 0.24 Neutral MSH6 P52701 R300M 300 R M 0.072 Neutral MSH6 P52701 R300N 300 R N 0.07 Neutral MSH6 P52701 R300P 300 R P 0.246 Neutral MSH6 P52701 R300Q 300 R Q 0.252 Neutral MSH6 P52701 R300S 300 R S 0.016 Neutral MSH6 P52701 R300T 300 R T 0.068 Neutral MSH6 P52701 R300V 300 R V 0.098 Neutral MSH6 P52701 R300W 300 R W 0.404 Neutral MSH6 P52701 R300Y 300 R Y 0.354 Neutral MSH6 P52701 K301A 301 K A 0.108 Neutral MSH6 P52701 K301C 301 K C 0.06 Neutral MSH6 P52701 K301D 301 K D 0.006 Neutral MSH6 P52701 K301E 301 K E 0.016 Neutral MSH6 P52701 K301F 301 K F 0.348 Neutral MSH6 P52701 K301G 301 K G 0.18 Neutral MSH6 P52701 K301H 301 K H 0.086 Neutral MSH6 P52701 K301I 301 K I 0.378 Neutral MSH6 P52701 K301L 301 K L 0.36 Neutral MSH6 P52701 K301M 301 K M 0.184 Neutral MSH6 P52701 K301N 301 K N 0.058 Neutral MSH6 P52701 K301P 301 K P 0.028 Neutral MSH6 P52701 K301Q 301 K Q 0.066 Neutral MSH6 P52701 K301R 301 K R 0.01 Neutral MSH6 P52701 K301S 301 K S 0.022 Neutral MSH6 P52701 K301T 301 K T 0.14 Neutral MSH6 P52701 K301V 301 K V 0.288 Neutral MSH6 P52701 K301W 301 K W 0.66 Pathogenic MSH6 P52701 K301Y 301 K Y 0.566 Pathogenic MSH6 P52701 R302A 302 R A 0.038 Neutral MSH6 P52701 R302C 302 R C 0.148 Neutral MSH6 P52701 R302D 302 R D 0.18 Neutral MSH6 P52701 R302E 302 R E 0.03 Neutral MSH6 P52701 R302F 302 R F 0.28 Neutral MSH6 P52701 R302G 302 R G 0.006 Neutral MSH6 P52701 R302H 302 R H 0.12 Neutral MSH6 P52701 R302I 302 R I 0.116 Neutral MSH6 P52701 R302K 302 R K 0.004 Neutral MSH6 P52701 R302L 302 R L 0.062 Neutral MSH6 P52701 R302M 302 R M 0.15 Neutral MSH6 P52701 R302N 302 R N 0.198 Neutral MSH6 P52701 R302P 302 R P 0.062 Neutral MSH6 P52701 R302Q 302 R Q 0.25 Neutral MSH6 P52701 R302S 302 R S 0.164 Neutral MSH6 P52701 R302T 302 R T 0.026 Neutral MSH6 P52701 R302V 302 R V 0.03 Neutral MSH6 P52701 R302W 302 R W 0.384 Neutral MSH6 P52701 R302Y 302 R Y 0.284 Neutral MSH6 P52701 M303A 303 M A 0.122 Neutral MSH6 P52701 M303C 303 M C 0.042 Neutral MSH6 P52701 M303D 303 M D 0.06 Neutral MSH6 P52701 M303E 303 M E 0.03 Neutral MSH6 P52701 M303F 303 M F 0.078 Neutral MSH6 P52701 M303G 303 M G 0.11 Neutral MSH6 P52701 M303H 303 M H 0.026 Neutral MSH6 P52701 M303I 303 M I 0.076 Neutral MSH6 P52701 M303K 303 M K 0.016 Neutral MSH6 P52701 M303L 303 M L 0.068 Neutral MSH6 P52701 M303N 303 M N 0.138 Neutral MSH6 P52701 M303P 303 M P 0.032 Neutral MSH6 P52701 M303Q 303 M Q 0.024 Neutral MSH6 P52701 M303R 303 M R 0.044 Neutral MSH6 P52701 M303S 303 M S 0.018 Neutral MSH6 P52701 M303T 303 M T 0.008 Neutral MSH6 P52701 M303V 303 M V 0.016 Neutral MSH6 P52701 M303W 303 M W 0.422 Neutral MSH6 P52701 M303Y 303 M Y 0.386 Neutral MSH6 P52701 V304A 304 V A 0 Neutral MSH6 P52701 V304C 304 V C 0.058 Neutral MSH6 P52701 V304D 304 V D 0.026 Neutral MSH6 P52701 V304E 304 V E 0.052 Neutral MSH6 P52701 V304F 304 V F 0.142 Neutral MSH6 P52701 V304G 304 V G 0.04 Neutral MSH6 P52701 V304H 304 V H 0.112 Neutral MSH6 P52701 V304I 304 V I 0.008 Neutral MSH6 P52701 V304K 304 V K 0.062 Neutral MSH6 P52701 V304L 304 V L 0.004 Neutral MSH6 P52701 V304M 304 V M 0.014 Neutral MSH6 P52701 V304N 304 V N 0.088 Neutral MSH6 P52701 V304P 304 V P 0.142 Neutral MSH6 P52701 V304Q 304 V Q 0.048 Neutral MSH6 P52701 V304R 304 V R 0.21 Neutral MSH6 P52701 V304S 304 V S 0.01 Neutral MSH6 P52701 V304T 304 V T 0.008 Neutral MSH6 P52701 V304W 304 V W 0.344 Neutral MSH6 P52701 V304Y 304 V Y 0.256 Neutral MSH6 P52701 T305A 305 T A 0.002 Neutral MSH6 P52701 T305C 305 T C 0.064 Neutral MSH6 P52701 T305D 305 T D 0.024 Neutral MSH6 P52701 T305E 305 T E 0.024 Neutral MSH6 P52701 T305F 305 T F 0.214 Neutral MSH6 P52701 T305G 305 T G 0.056 Neutral MSH6 P52701 T305H 305 T H 0.084 Neutral MSH6 P52701 T305I 305 T I 0.076 Neutral MSH6 P52701 T305K 305 T K 0.002 Neutral MSH6 P52701 T305L 305 T L 0.074 Neutral MSH6 P52701 T305M 305 T M 0.048 Neutral MSH6 P52701 T305N 305 T N 0 Neutral MSH6 P52701 T305P 305 T P 0.008 Neutral MSH6 P52701 T305Q 305 T Q 0.01 Neutral MSH6 P52701 T305R 305 T R 0.156 Neutral MSH6 P52701 T305S 305 T S 0 Neutral MSH6 P52701 T305V 305 T V 0.02 Neutral MSH6 P52701 T305W 305 T W 0.466 Neutral MSH6 P52701 T305Y 305 T Y 0.424 Neutral MSH6 P52701 G306A 306 G A 0.002 Neutral MSH6 P52701 G306C 306 G C 0.14 Neutral MSH6 P52701 G306D 306 G D 0.134 Neutral MSH6 P52701 G306E 306 G E 0.172 Neutral MSH6 P52701 G306F 306 G F 0.498 Neutral MSH6 P52701 G306H 306 G H 0.37 Neutral MSH6 P52701 G306I 306 G I 0.428 Neutral MSH6 P52701 G306K 306 G K 0.286 Neutral MSH6 P52701 G306L 306 G L 0.338 Neutral MSH6 P52701 G306M 306 G M 0.422 Neutral MSH6 P52701 G306N 306 G N 0.252 Neutral MSH6 P52701 G306P 306 G P 0.36 Neutral MSH6 P52701 G306Q 306 G Q 0.206 Neutral MSH6 P52701 G306R 306 G R 0.286 Neutral MSH6 P52701 G306S 306 G S 0.016 Neutral MSH6 P52701 G306T 306 G T 0.25 Neutral MSH6 P52701 G306V 306 G V 0.306 Neutral MSH6 P52701 G306W 306 G W 0.498 Neutral MSH6 P52701 G306Y 306 G Y 0.5 Pathogenic MSH6 P52701 N307A 307 N A 0.004 Neutral MSH6 P52701 N307C 307 N C 0.148 Neutral MSH6 P52701 N307D 307 N D 0.008 Neutral MSH6 P52701 N307E 307 N E 0.014 Neutral MSH6 P52701 N307F 307 N F 0.34 Neutral MSH6 P52701 N307G 307 N G 0.044 Neutral MSH6 P52701 N307H 307 N H 0.132 Neutral MSH6 P52701 N307I 307 N I 0.232 Neutral MSH6 P52701 N307K 307 N K 0.036 Neutral MSH6 P52701 N307L 307 N L 0.108 Neutral MSH6 P52701 N307M 307 N M 0.236 Neutral MSH6 P52701 N307P 307 N P 0.158 Neutral MSH6 P52701 N307Q 307 N Q 0.096 Neutral MSH6 P52701 N307R 307 N R 0.136 Neutral MSH6 P52701 N307S 307 N S 0 Neutral MSH6 P52701 N307T 307 N T 0.008 Neutral MSH6 P52701 N307V 307 N V 0.28 Neutral MSH6 P52701 N307W 307 N W 0.446 Neutral MSH6 P52701 N307Y 307 N Y 0.402 Neutral MSH6 P52701 G308A 308 G A 0.018 Neutral MSH6 P52701 G308C 308 G C 0.14 Neutral MSH6 P52701 G308D 308 G D 0.134 Neutral MSH6 P52701 G308E 308 G E 0.174 Neutral MSH6 P52701 G308F 308 G F 0.388 Neutral MSH6 P52701 G308H 308 G H 0.442 Neutral MSH6 P52701 G308I 308 G I 0.416 Neutral MSH6 P52701 G308K 308 G K 0.282 Neutral MSH6 P52701 G308L 308 G L 0.37 Neutral MSH6 P52701 G308M 308 G M 0.34 Neutral MSH6 P52701 G308N 308 G N 0.168 Neutral MSH6 P52701 G308P 308 G P 0.35 Neutral MSH6 P52701 G308Q 308 G Q 0.21 Neutral MSH6 P52701 G308R 308 G R 0.304 Neutral MSH6 P52701 G308S 308 G S 0.016 Neutral MSH6 P52701 G308T 308 G T 0.25 Neutral MSH6 P52701 G308V 308 G V 0.306 Neutral MSH6 P52701 G308W 308 G W 0.498 Neutral MSH6 P52701 G308Y 308 G Y 0.5 Pathogenic MSH6 P52701 S309A 309 S A 0.01 Neutral MSH6 P52701 S309C 309 S C 0.032 Neutral MSH6 P52701 S309D 309 S D 0.002 Neutral MSH6 P52701 S309E 309 S E 0.124 Neutral MSH6 P52701 S309F 309 S F 0.25 Neutral MSH6 P52701 S309G 309 S G 0 Neutral MSH6 P52701 S309H 309 S H 0.238 Neutral MSH6 P52701 S309I 309 S I 0.196 Neutral MSH6 P52701 S309K 309 S K 0.162 Neutral MSH6 P52701 S309L 309 S L 0.068 Neutral MSH6 P52701 S309M 309 S M 0.332 Neutral MSH6 P52701 S309N 309 S N 0 Neutral MSH6 P52701 S309P 309 S P 0.064 Neutral MSH6 P52701 S309Q 309 S Q 0.132 Neutral MSH6 P52701 S309R 309 S R 0.136 Neutral MSH6 P52701 S309T 309 S T 0.046 Neutral MSH6 P52701 S309V 309 S V 0.288 Neutral MSH6 P52701 S309W 309 S W 0.49 Neutral MSH6 P52701 S309Y 309 S Y 0.448 Neutral MSH6 P52701 G31A 31 G A 0.002 Neutral MSH6 P52701 G31C 31 G C 0.14 Neutral MSH6 P52701 G31D 31 G D 0.154 Neutral MSH6 P52701 G31E 31 G E 0.304 Neutral MSH6 P52701 G31F 31 G F 0.498 Neutral MSH6 P52701 G31H 31 G H 0.442 Neutral MSH6 P52701 G31I 31 G I 0.412 Neutral MSH6 P52701 G31K 31 G K 0.416 Neutral MSH6 P52701 G31L 31 G L 0.412 Neutral MSH6 P52701 G31M 31 G M 0.422 Neutral MSH6 P52701 G31N 31 G N 0.168 Neutral MSH6 P52701 G31P 31 G P 0.442 Neutral MSH6 P52701 G31Q 31 G Q 0.262 Neutral MSH6 P52701 G31R 31 G R 0.468 Neutral MSH6 P52701 G31S 31 G S 0.046 Neutral MSH6 P52701 G31T 31 G T 0.274 Neutral MSH6 P52701 G31V 31 G V 0.318 Neutral MSH6 P52701 G31W 31 G W 0.498 Neutral MSH6 P52701 G31Y 31 G Y 0.5 Pathogenic MSH6 P52701 L310A 310 L A 0.008 Neutral MSH6 P52701 L310C 310 L C 0.094 Neutral MSH6 P52701 L310D 310 L D 0.054 Neutral MSH6 P52701 L310E 310 L E 0.028 Neutral MSH6 P52701 L310F 310 L F 0.118 Neutral MSH6 P52701 L310G 310 L G 0.184 Neutral MSH6 P52701 L310H 310 L H 0.084 Neutral MSH6 P52701 L310I 310 L I 0.004 Neutral MSH6 P52701 L310K 310 L K 0.026 Neutral MSH6 P52701 L310M 310 L M 0.18 Neutral MSH6 P52701 L310N 310 L N 0.148 Neutral MSH6 P52701 L310P 310 L P 0.09 Neutral MSH6 P52701 L310Q 310 L Q 0.01 Neutral MSH6 P52701 L310R 310 L R 0.25 Neutral MSH6 P52701 L310S 310 L S 0.01 Neutral MSH6 P52701 L310T 310 L T 0.01 Neutral MSH6 P52701 L310V 310 L V 0 Neutral MSH6 P52701 L310W 310 L W 0.334 Neutral MSH6 P52701 L310Y 310 L Y 0.282 Neutral MSH6 P52701 K311A 311 K A 0.096 Neutral MSH6 P52701 K311C 311 K C 0.028 Neutral MSH6 P52701 K311D 311 K D 0.002 Neutral MSH6 P52701 K311E 311 K E 0.004 Neutral MSH6 P52701 K311F 311 K F 0.114 Neutral MSH6 P52701 K311G 311 K G 0.044 Neutral MSH6 P52701 K311H 311 K H 0.048 Neutral MSH6 P52701 K311I 311 K I 0.19 Neutral MSH6 P52701 K311L 311 K L 0.038 Neutral MSH6 P52701 K311M 311 K M 0.146 Neutral MSH6 P52701 K311N 311 K N 0.082 Neutral MSH6 P52701 K311P 311 K P 0.01 Neutral MSH6 P52701 K311Q 311 K Q 0.006 Neutral MSH6 P52701 K311R 311 K R 0.002 Neutral MSH6 P52701 K311S 311 K S 0.014 Neutral MSH6 P52701 K311T 311 K T 0.014 Neutral MSH6 P52701 K311V 311 K V 0.12 Neutral MSH6 P52701 K311W 311 K W 0.396 Neutral MSH6 P52701 K311Y 311 K Y 0.326 Neutral MSH6 P52701 R312A 312 R A 0.08 Neutral MSH6 P52701 R312C 312 R C 0.154 Neutral MSH6 P52701 R312D 312 R D 0.074 Neutral MSH6 P52701 R312E 312 R E 0.168 Neutral MSH6 P52701 R312F 312 R F 0.28 Neutral MSH6 P52701 R312G 312 R G 0.006 Neutral MSH6 P52701 R312H 312 R H 0.122 Neutral MSH6 P52701 R312I 312 R I 0.31 Neutral MSH6 P52701 R312K 312 R K 0.004 Neutral MSH6 P52701 R312L 312 R L 0.066 Neutral MSH6 P52701 R312M 312 R M 0.16 Neutral MSH6 P52701 R312N 312 R N 0.07 Neutral MSH6 P52701 R312P 312 R P 0.03 Neutral MSH6 P52701 R312Q 312 R Q 0.252 Neutral MSH6 P52701 R312S 312 R S 0.016 Neutral MSH6 P52701 R312T 312 R T 0.018 Neutral MSH6 P52701 R312V 312 R V 0.184 Neutral MSH6 P52701 R312W 312 R W 0.402 Neutral MSH6 P52701 R312Y 312 R Y 0.292 Neutral MSH6 P52701 K313A 313 K A 0.028 Neutral MSH6 P52701 K313C 313 K C 0.028 Neutral MSH6 P52701 K313D 313 K D 0.066 Neutral MSH6 P52701 K313E 313 K E 0.004 Neutral MSH6 P52701 K313F 313 K F 0.212 Neutral MSH6 P52701 K313G 313 K G 0.042 Neutral MSH6 P52701 K313H 313 K H 0.048 Neutral MSH6 P52701 K313I 313 K I 0.042 Neutral MSH6 P52701 K313L 313 K L 0.036 Neutral MSH6 P52701 K313M 313 K M 0.146 Neutral MSH6 P52701 K313N 313 K N 0.006 Neutral MSH6 P52701 K313P 313 K P 0.016 Neutral MSH6 P52701 K313Q 313 K Q 0.024 Neutral MSH6 P52701 K313R 313 K R 0.002 Neutral MSH6 P52701 K313S 313 K S 0.012 Neutral MSH6 P52701 K313T 313 K T 0.012 Neutral MSH6 P52701 K313V 313 K V 0.026 Neutral MSH6 P52701 K313W 313 K W 0.348 Neutral MSH6 P52701 K313Y 313 K Y 0.326 Neutral MSH6 P52701 S314A 314 S A 0.01 Neutral MSH6 P52701 S314C 314 S C 0.032 Neutral MSH6 P52701 S314D 314 S D 0.002 Neutral MSH6 P52701 S314E 314 S E 0.124 Neutral MSH6 P52701 S314F 314 S F 0.264 Neutral MSH6 P52701 S314G 314 S G 0.01 Neutral MSH6 P52701 S314H 314 S H 0.238 Neutral MSH6 P52701 S314I 314 S I 0.124 Neutral MSH6 P52701 S314K 314 S K 0.162 Neutral MSH6 P52701 S314L 314 S L 0.028 Neutral MSH6 P52701 S314M 314 S M 0.332 Neutral MSH6 P52701 S314N 314 S N 0.002 Neutral MSH6 P52701 S314P 314 S P 0.056 Neutral MSH6 P52701 S314Q 314 S Q 0.132 Neutral MSH6 P52701 S314R 314 S R 0.156 Neutral MSH6 P52701 S314T 314 S T 0.022 Neutral MSH6 P52701 S314V 314 S V 0.134 Neutral MSH6 P52701 S314W 314 S W 0.49 Neutral MSH6 P52701 S314Y 314 S Y 0.448 Neutral MSH6 P52701 S315A 315 S A 0.01 Neutral MSH6 P52701 S315C 315 S C 0.022 Neutral MSH6 P52701 S315D 315 S D 0.002 Neutral MSH6 P52701 S315E 315 S E 0.138 Neutral MSH6 P52701 S315F 315 S F 0.276 Neutral MSH6 P52701 S315G 315 S G 0.01 Neutral MSH6 P52701 S315H 315 S H 0.188 Neutral MSH6 P52701 S315I 315 S I 0.026 Neutral MSH6 P52701 S315K 315 S K 0.162 Neutral MSH6 P52701 S315L 315 S L 0.032 Neutral MSH6 P52701 S315M 315 S M 0.332 Neutral MSH6 P52701 S315N 315 S N 0 Neutral MSH6 P52701 S315P 315 S P 0.064 Neutral MSH6 P52701 S315Q 315 S Q 0.158 Neutral MSH6 P52701 S315R 315 S R 0.154 Neutral MSH6 P52701 S315T 315 S T 0.104 Neutral MSH6 P52701 S315V 315 S V 0.034 Neutral MSH6 P52701 S315W 315 S W 0.49 Neutral MSH6 P52701 S315Y 315 S Y 0.448 Neutral MSH6 P52701 R316A 316 R A 0.038 Neutral MSH6 P52701 R316C 316 R C 0.148 Neutral MSH6 P52701 R316D 316 R D 0.02 Neutral MSH6 P52701 R316E 316 R E 0.022 Neutral MSH6 P52701 R316F 316 R F 0.28 Neutral MSH6 P52701 R316G 316 R G 0.002 Neutral MSH6 P52701 R316H 316 R H 0.12 Neutral MSH6 P52701 R316I 316 R I 0.308 Neutral MSH6 P52701 R316K 316 R K 0.004 Neutral MSH6 P52701 R316L 316 R L 0.012 Neutral MSH6 P52701 R316M 316 R M 0.15 Neutral MSH6 P52701 R316N 316 R N 0.016 Neutral MSH6 P52701 R316P 316 R P 0.236 Neutral MSH6 P52701 R316Q 316 R Q 0.16 Neutral MSH6 P52701 R316S 316 R S 0.016 Neutral MSH6 P52701 R316T 316 R T 0.016 Neutral MSH6 P52701 R316V 316 R V 0.094 Neutral MSH6 P52701 R316W 316 R W 0.384 Neutral MSH6 P52701 R316Y 316 R Y 0.284 Neutral MSH6 P52701 K317A 317 K A 0.028 Neutral MSH6 P52701 K317C 317 K C 0.046 Neutral MSH6 P52701 K317D 317 K D 0.002 Neutral MSH6 P52701 K317E 317 K E 0.004 Neutral MSH6 P52701 K317F 317 K F 0.23 Neutral MSH6 P52701 K317G 317 K G 0.044 Neutral MSH6 P52701 K317H 317 K H 0.018 Neutral MSH6 P52701 K317I 317 K I 0.222 Neutral MSH6 P52701 K317L 317 K L 0.038 Neutral MSH6 P52701 K317M 317 K M 0.106 Neutral MSH6 P52701 K317N 317 K N 0.05 Neutral MSH6 P52701 K317P 317 K P 0.01 Neutral MSH6 P52701 K317Q 317 K Q 0.006 Neutral MSH6 P52701 K317R 317 K R 0.012 Neutral MSH6 P52701 K317S 317 K S 0.014 Neutral MSH6 P52701 K317T 317 K T 0.012 Neutral MSH6 P52701 K317V 317 K V 0.184 Neutral MSH6 P52701 K317W 317 K W 0.396 Neutral MSH6 P52701 K317Y 317 K Y 0.326 Neutral MSH6 P52701 E318A 318 E A 0.066 Neutral MSH6 P52701 E318C 318 E C 0.064 Neutral MSH6 P52701 E318D 318 E D 0 Neutral MSH6 P52701 E318F 318 E F 0.164 Neutral MSH6 P52701 E318G 318 E G 0.084 Neutral MSH6 P52701 E318H 318 E H 0.104 Neutral MSH6 P52701 E318I 318 E I 0.128 Neutral MSH6 P52701 E318K 318 E K 0.002 Neutral MSH6 P52701 E318L 318 E L 0.038 Neutral MSH6 P52701 E318M 318 E M 0.036 Neutral MSH6 P52701 E318N 318 E N 0.04 Neutral MSH6 P52701 E318P 318 E P 0.042 Neutral MSH6 P52701 E318Q 318 E Q 0.056 Neutral MSH6 P52701 E318R 318 E R 0.03 Neutral MSH6 P52701 E318S 318 E S 0.014 Neutral MSH6 P52701 E318T 318 E T 0.006 Neutral MSH6 P52701 E318V 318 E V 0.04 Neutral MSH6 P52701 E318W 318 E W 0.43 Neutral MSH6 P52701 E318Y 318 E Y 0.398 Neutral MSH6 P52701 T319A 319 T A 0.002 Neutral MSH6 P52701 T319C 319 T C 0.064 Neutral MSH6 P52701 T319D 319 T D 0.02 Neutral MSH6 P52701 T319E 319 T E 0.024 Neutral MSH6 P52701 T319F 319 T F 0.214 Neutral MSH6 P52701 T319G 319 T G 0.002 Neutral MSH6 P52701 T319H 319 T H 0.084 Neutral MSH6 P52701 T319I 319 T I 0.048 Neutral MSH6 P52701 T319K 319 T K 0.002 Neutral MSH6 P52701 T319L 319 T L 0.016 Neutral MSH6 P52701 T319M 319 T M 0.026 Neutral MSH6 P52701 T319N 319 T N 0 Neutral MSH6 P52701 T319P 319 T P 0.056 Neutral MSH6 P52701 T319Q 319 T Q 0.052 Neutral MSH6 P52701 T319R 319 T R 0.14 Neutral MSH6 P52701 T319S 319 T S 0.004 Neutral MSH6 P52701 T319V 319 T V 0.016 Neutral MSH6 P52701 T319W 319 T W 0.466 Neutral MSH6 P52701 T319Y 319 T Y 0.424 Neutral MSH6 P52701 G32A 32 G A 0.018 Neutral MSH6 P52701 G32C 32 G C 0.14 Neutral MSH6 P52701 G32D 32 G D 0.154 Neutral MSH6 P52701 G32E 32 G E 0.198 Neutral MSH6 P52701 G32F 32 G F 0.498 Neutral MSH6 P52701 G32H 32 G H 0.442 Neutral MSH6 P52701 G32I 32 G I 0.412 Neutral MSH6 P52701 G32K 32 G K 0.358 Neutral MSH6 P52701 G32L 32 G L 0.412 Neutral MSH6 P52701 G32M 32 G M 0.422 Neutral MSH6 P52701 G32N 32 G N 0.252 Neutral MSH6 P52701 G32P 32 G P 0.402 Neutral MSH6 P52701 G32Q 32 G Q 0.262 Neutral MSH6 P52701 G32R 32 G R 0.292 Neutral MSH6 P52701 G32S 32 G S 0.11 Neutral MSH6 P52701 G32T 32 G T 0.274 Neutral MSH6 P52701 G32V 32 G V 0.39 Neutral MSH6 P52701 G32W 32 G W 0.498 Neutral MSH6 P52701 G32Y 32 G Y 0.5 Pathogenic MSH6 P52701 P320A 320 P A 0.032 Neutral MSH6 P52701 P320C 320 P C 0.148 Neutral MSH6 P52701 P320D 320 P D 0.028 Neutral MSH6 P52701 P320E 320 P E 0.106 Neutral MSH6 P52701 P320F 320 P F 0.268 Neutral MSH6 P52701 P320G 320 P G 0.01 Neutral MSH6 P52701 P320H 320 P H 0.266 Neutral MSH6 P52701 P320I 320 P I 0.1 Neutral MSH6 P52701 P320K 320 P K 0.06 Neutral MSH6 P52701 P320L 320 P L 0.042 Neutral MSH6 P52701 P320M 320 P M 0.178 Neutral MSH6 P52701 P320N 320 P N 0.048 Neutral MSH6 P52701 P320Q 320 P Q 0.096 Neutral MSH6 P52701 P320R 320 P R 0.202 Neutral MSH6 P52701 P320S 320 P S 0.002 Neutral MSH6 P52701 P320T 320 P T 0.016 Neutral MSH6 P52701 P320V 320 P V 0.046 Neutral MSH6 P52701 P320W 320 P W 0.39 Neutral MSH6 P52701 P320Y 320 P Y 0.27 Neutral MSH6 P52701 S321A 321 S A 0.01 Neutral MSH6 P52701 S321C 321 S C 0.032 Neutral MSH6 P52701 S321D 321 S D 0.002 Neutral MSH6 P52701 S321E 321 S E 0.138 Neutral MSH6 P52701 S321F 321 S F 0.276 Neutral MSH6 P52701 S321G 321 S G 0.064 Neutral MSH6 P52701 S321H 321 S H 0.188 Neutral MSH6 P52701 S321I 321 S I 0.17 Neutral MSH6 P52701 S321K 321 S K 0.162 Neutral MSH6 P52701 S321L 321 S L 0.042 Neutral MSH6 P52701 S321M 321 S M 0.28 Neutral MSH6 P52701 S321N 321 S N 0.004 Neutral MSH6 P52701 S321P 321 S P 0.056 Neutral MSH6 P52701 S321Q 321 S Q 0.17 Neutral MSH6 P52701 S321R 321 S R 0.248 Neutral MSH6 P52701 S321T 321 S T 0.176 Neutral MSH6 P52701 S321V 321 S V 0.288 Neutral MSH6 P52701 S321W 321 S W 0.49 Neutral MSH6 P52701 S321Y 321 S Y 0.448 Neutral MSH6 P52701 A322C 322 A C 0.182 Neutral MSH6 P52701 A322D 322 A D 0.316 Neutral MSH6 P52701 A322E 322 A E 0.288 Neutral MSH6 P52701 A322F 322 A F 0.468 Neutral MSH6 P52701 A322G 322 A G 0.074 Neutral MSH6 P52701 A322H 322 A H 0.304 Neutral MSH6 P52701 A322I 322 A I 0.352 Neutral MSH6 P52701 A322K 322 A K 0.268 Neutral MSH6 P52701 A322L 322 A L 0.318 Neutral MSH6 P52701 A322M 322 A M 0.29 Neutral MSH6 P52701 A322N 322 A N 0.296 Neutral MSH6 P52701 A322P 322 A P 0.036 Neutral MSH6 P52701 A322Q 322 A Q 0.286 Neutral MSH6 P52701 A322R 322 A R 0.326 Neutral MSH6 P52701 A322S 322 A S 0.01 Neutral MSH6 P52701 A322T 322 A T 0.018 Neutral MSH6 P52701 A322V 322 A V 0.04 Neutral MSH6 P52701 A322W 322 A W 0.504 Pathogenic MSH6 P52701 A322Y 322 A Y 0.5 Pathogenic MSH6 P52701 T323A 323 T A 0 Neutral MSH6 P52701 T323C 323 T C 0.064 Neutral MSH6 P52701 T323D 323 T D 0.038 Neutral MSH6 P52701 T323E 323 T E 0.05 Neutral MSH6 P52701 T323F 323 T F 0.214 Neutral MSH6 P52701 T323G 323 T G 0.056 Neutral MSH6 P52701 T323H 323 T H 0.084 Neutral MSH6 P52701 T323I 323 T I 0.076 Neutral MSH6 P52701 T323K 323 T K 0.042 Neutral MSH6 P52701 T323L 323 T L 0.074 Neutral MSH6 P52701 T323M 323 T M 0.098 Neutral MSH6 P52701 T323N 323 T N 0.02 Neutral MSH6 P52701 T323P 323 T P 0.008 Neutral MSH6 P52701 T323Q 323 T Q 0.01 Neutral MSH6 P52701 T323R 323 T R 0.158 Neutral MSH6 P52701 T323S 323 T S 0 Neutral MSH6 P52701 T323V 323 T V 0.212 Neutral MSH6 P52701 T323W 323 T W 0.466 Neutral MSH6 P52701 T323Y 323 T Y 0.424 Neutral MSH6 P52701 K324A 324 K A 0.028 Neutral MSH6 P52701 K324C 324 K C 0.036 Neutral MSH6 P52701 K324D 324 K D 0.05 Neutral MSH6 P52701 K324E 324 K E 0.03 Neutral MSH6 P52701 K324F 324 K F 0.22 Neutral MSH6 P52701 K324G 324 K G 0.116 Neutral MSH6 P52701 K324H 324 K H 0.048 Neutral MSH6 P52701 K324I 324 K I 0.23 Neutral MSH6 P52701 K324L 324 K L 0.108 Neutral MSH6 P52701 K324M 324 K M 0.112 Neutral MSH6 P52701 K324N 324 K N 0.05 Neutral MSH6 P52701 K324P 324 K P 0.012 Neutral MSH6 P52701 K324Q 324 K Q 0.048 Neutral MSH6 P52701 K324R 324 K R 0.002 Neutral MSH6 P52701 K324S 324 K S 0.014 Neutral MSH6 P52701 K324T 324 K T 0.09 Neutral MSH6 P52701 K324V 324 K V 0.056 Neutral MSH6 P52701 K324W 324 K W 0.414 Neutral MSH6 P52701 K324Y 324 K Y 0.344 Neutral MSH6 P52701 Q325A 325 Q A 0.076 Neutral MSH6 P52701 Q325C 325 Q C 0.082 Neutral MSH6 P52701 Q325D 325 Q D 0.046 Neutral MSH6 P52701 Q325E 325 Q E 0.008 Neutral MSH6 P52701 Q325F 325 Q F 0.362 Neutral MSH6 P52701 Q325G 325 Q G 0.136 Neutral MSH6 P52701 Q325H 325 Q H 0.214 Neutral MSH6 P52701 Q325I 325 Q I 0.354 Neutral MSH6 P52701 Q325K 325 Q K 0.02 Neutral MSH6 P52701 Q325L 325 Q L 0.242 Neutral MSH6 P52701 Q325M 325 Q M 0.21 Neutral MSH6 P52701 Q325N 325 Q N 0.094 Neutral MSH6 P52701 Q325P 325 Q P 0.294 Neutral MSH6 P52701 Q325R 325 Q R 0.004 Neutral MSH6 P52701 Q325S 325 Q S 0.036 Neutral MSH6 P52701 Q325T 325 Q T 0.002 Neutral MSH6 P52701 Q325V 325 Q V 0.268 Neutral MSH6 P52701 Q325W 325 Q W 0.42 Neutral MSH6 P52701 Q325Y 325 Q Y 0.362 Neutral MSH6 P52701 A326C 326 A C 0.182 Neutral MSH6 P52701 A326D 326 A D 0.316 Neutral MSH6 P52701 A326E 326 A E 0.276 Neutral MSH6 P52701 A326F 326 A F 0.408 Neutral MSH6 P52701 A326G 326 A G 0.074 Neutral MSH6 P52701 A326H 326 A H 0.304 Neutral MSH6 P52701 A326I 326 A I 0.406 Neutral MSH6 P52701 A326K 326 A K 0.262 Neutral MSH6 P52701 A326L 326 A L 0.4 Neutral MSH6 P52701 A326M 326 A M 0.29 Neutral MSH6 P52701 A326N 326 A N 0.29 Neutral MSH6 P52701 A326P 326 A P 0.076 Neutral MSH6 P52701 A326Q 326 A Q 0.286 Neutral MSH6 P52701 A326R 326 A R 0.318 Neutral MSH6 P52701 A326S 326 A S 0.008 Neutral MSH6 P52701 A326T 326 A T 0.014 Neutral MSH6 P52701 A326V 326 A V 0.04 Neutral MSH6 P52701 A326W 326 A W 0.504 Pathogenic MSH6 P52701 A326Y 326 A Y 0.5 Pathogenic MSH6 P52701 T327A 327 T A 0 Neutral MSH6 P52701 T327C 327 T C 0.064 Neutral MSH6 P52701 T327D 327 T D 0.038 Neutral MSH6 P52701 T327E 327 T E 0.04 Neutral MSH6 P52701 T327F 327 T F 0.204 Neutral MSH6 P52701 T327G 327 T G 0.036 Neutral MSH6 P52701 T327H 327 T H 0.084 Neutral MSH6 P52701 T327I 327 T I 0.048 Neutral MSH6 P52701 T327K 327 T K 0.002 Neutral MSH6 P52701 T327L 327 T L 0.074 Neutral MSH6 P52701 T327M 327 T M 0.048 Neutral MSH6 P52701 T327N 327 T N 0.02 Neutral MSH6 P52701 T327P 327 T P 0.008 Neutral MSH6 P52701 T327Q 327 T Q 0.052 Neutral MSH6 P52701 T327R 327 T R 0.174 Neutral MSH6 P52701 T327S 327 T S 0 Neutral MSH6 P52701 T327V 327 T V 0.016 Neutral MSH6 P52701 T327W 327 T W 0.466 Neutral MSH6 P52701 T327Y 327 T Y 0.424 Neutral MSH6 P52701 S328A 328 S A 0.01 Neutral MSH6 P52701 S328C 328 S C 0.022 Neutral MSH6 P52701 S328D 328 S D 0.008 Neutral MSH6 P52701 S328E 328 S E 0.138 Neutral MSH6 P52701 S328F 328 S F 0.25 Neutral MSH6 P52701 S328G 328 S G 0 Neutral MSH6 P52701 S328H 328 S H 0.238 Neutral MSH6 P52701 S328I 328 S I 0.124 Neutral MSH6 P52701 S328K 328 S K 0.146 Neutral MSH6 P52701 S328L 328 S L 0.028 Neutral MSH6 P52701 S328M 328 S M 0.332 Neutral MSH6 P52701 S328N 328 S N 0.002 Neutral MSH6 P52701 S328P 328 S P 0.062 Neutral MSH6 P52701 S328Q 328 S Q 0.16 Neutral MSH6 P52701 S328R 328 S R 0.136 Neutral MSH6 P52701 S328T 328 S T 0.022 Neutral MSH6 P52701 S328V 328 S V 0.288 Neutral MSH6 P52701 S328W 328 S W 0.49 Neutral MSH6 P52701 S328Y 328 S Y 0.448 Neutral MSH6 P52701 I329A 329 I A 0.006 Neutral MSH6 P52701 I329C 329 I C 0.09 Neutral MSH6 P52701 I329D 329 I D 0.028 Neutral MSH6 P52701 I329E 329 I E 0.038 Neutral MSH6 P52701 I329F 329 I F 0.206 Neutral MSH6 P52701 I329G 329 I G 0.192 Neutral MSH6 P52701 I329H 329 I H 0.08 Neutral MSH6 P52701 I329K 329 I K 0.118 Neutral MSH6 P52701 I329L 329 I L 0 Neutral MSH6 P52701 I329M 329 I M 0.084 Neutral MSH6 P52701 I329N 329 I N 0.096 Neutral MSH6 P52701 I329P 329 I P 0.186 Neutral MSH6 P52701 I329Q 329 I Q 0.138 Neutral MSH6 P52701 I329R 329 I R 0.244 Neutral MSH6 P52701 I329S 329 I S 0.072 Neutral MSH6 P52701 I329T 329 I T 0.002 Neutral MSH6 P52701 I329V 329 I V 0 Neutral MSH6 P52701 I329W 329 I W 0.344 Neutral MSH6 P52701 I329Y 329 I Y 0.298 Neutral MSH6 P52701 R33A 33 R A 0.036 Neutral MSH6 P52701 R33C 33 R C 0.148 Neutral MSH6 P52701 R33D 33 R D 0.18 Neutral MSH6 P52701 R33E 33 R E 0.128 Neutral MSH6 P52701 R33F 33 R F 0.28 Neutral MSH6 P52701 R33G 33 R G 0.002 Neutral MSH6 P52701 R33H 33 R H 0.12 Neutral MSH6 P52701 R33I 33 R I 0.304 Neutral MSH6 P52701 R33K 33 R K 0.172 Neutral MSH6 P52701 R33L 33 R L 0.272 Neutral MSH6 P52701 R33M 33 R M 0.164 Neutral MSH6 P52701 R33N 33 R N 0.176 Neutral MSH6 P52701 R33P 33 R P 0.106 Neutral MSH6 P52701 R33Q 33 R Q 0.16 Neutral MSH6 P52701 R33S 33 R S 0.164 Neutral MSH6 P52701 R33T 33 R T 0.142 Neutral MSH6 P52701 R33V 33 R V 0.178 Neutral MSH6 P52701 R33W 33 R W 0.384 Neutral MSH6 P52701 R33Y 33 R Y 0.284 Neutral MSH6 P52701 S330A 330 S A 0.012 Neutral MSH6 P52701 S330C 330 S C 0.022 Neutral MSH6 P52701 S330D 330 S D 0.024 Neutral MSH6 P52701 S330E 330 S E 0.122 Neutral MSH6 P52701 S330F 330 S F 0.264 Neutral MSH6 P52701 S330G 330 S G 0 Neutral MSH6 P52701 S330H 330 S H 0.188 Neutral MSH6 P52701 S330I 330 S I 0.17 Neutral MSH6 P52701 S330K 330 S K 0.146 Neutral MSH6 P52701 S330L 330 S L 0.032 Neutral MSH6 P52701 S330M 330 S M 0.252 Neutral MSH6 P52701 S330N 330 S N 0.012 Neutral MSH6 P52701 S330P 330 S P 0.062 Neutral MSH6 P52701 S330Q 330 S Q 0.132 Neutral MSH6 P52701 S330R 330 S R 0.138 Neutral MSH6 P52701 S330T 330 S T 0.02 Neutral MSH6 P52701 S330V 330 S V 0.068 Neutral MSH6 P52701 S330W 330 S W 0.49 Neutral MSH6 P52701 S330Y 330 S Y 0.448 Neutral MSH6 P52701 S331A 331 S A 0.01 Neutral MSH6 P52701 S331C 331 S C 0.022 Neutral MSH6 P52701 S331D 331 S D 0.002 Neutral MSH6 P52701 S331E 331 S E 0.122 Neutral MSH6 P52701 S331F 331 S F 0.25 Neutral MSH6 P52701 S331G 331 S G 0.036 Neutral MSH6 P52701 S331H 331 S H 0.238 Neutral MSH6 P52701 S331I 331 S I 0.026 Neutral MSH6 P52701 S331K 331 S K 0.166 Neutral MSH6 P52701 S331L 331 S L 0.032 Neutral MSH6 P52701 S331M 331 S M 0.28 Neutral MSH6 P52701 S331N 331 S N 0.012 Neutral MSH6 P52701 S331P 331 S P 0.056 Neutral MSH6 P52701 S331Q 331 S Q 0.16 Neutral MSH6 P52701 S331R 331 S R 0.136 Neutral MSH6 P52701 S331T 331 S T 0.02 Neutral MSH6 P52701 S331V 331 S V 0.034 Neutral MSH6 P52701 S331W 331 S W 0.49 Neutral MSH6 P52701 S331Y 331 S Y 0.448 Neutral MSH6 P52701 E332A 332 E A 0.144 Neutral MSH6 P52701 E332C 332 E C 0.068 Neutral MSH6 P52701 E332D 332 E D 0 Neutral MSH6 P52701 E332F 332 E F 0.272 Neutral MSH6 P52701 E332G 332 E G 0.024 Neutral MSH6 P52701 E332H 332 E H 0.096 Neutral MSH6 P52701 E332I 332 E I 0.128 Neutral MSH6 P52701 E332K 332 E K 0.002 Neutral MSH6 P52701 E332L 332 E L 0.286 Neutral MSH6 P52701 E332M 332 E M 0.076 Neutral MSH6 P52701 E332N 332 E N 0.002 Neutral MSH6 P52701 E332P 332 E P 0.042 Neutral MSH6 P52701 E332Q 332 E Q 0.012 Neutral MSH6 P52701 E332R 332 E R 0.036 Neutral MSH6 P52701 E332S 332 E S 0.014 Neutral MSH6 P52701 E332T 332 E T 0.02 Neutral MSH6 P52701 E332V 332 E V 0.232 Neutral MSH6 P52701 E332W 332 E W 0.43 Neutral MSH6 P52701 E332Y 332 E Y 0.338 Neutral MSH6 P52701 T333A 333 T A 0 Neutral MSH6 P52701 T333C 333 T C 0.064 Neutral MSH6 P52701 T333D 333 T D 0.058 Neutral MSH6 P52701 T333E 333 T E 0.05 Neutral MSH6 P52701 T333F 333 T F 0.194 Neutral MSH6 P52701 T333G 333 T G 0.002 Neutral MSH6 P52701 T333H 333 T H 0.084 Neutral MSH6 P52701 T333I 333 T I 0.048 Neutral MSH6 P52701 T333K 333 T K 0.002 Neutral MSH6 P52701 T333L 333 T L 0.016 Neutral MSH6 P52701 T333M 333 T M 0.044 Neutral MSH6 P52701 T333N 333 T N 0.002 Neutral MSH6 P52701 T333P 333 T P 0.008 Neutral MSH6 P52701 T333Q 333 T Q 0.052 Neutral MSH6 P52701 T333R 333 T R 0.156 Neutral MSH6 P52701 T333S 333 T S 0 Neutral MSH6 P52701 T333V 333 T V 0.016 Neutral MSH6 P52701 T333W 333 T W 0.466 Neutral MSH6 P52701 T333Y 333 T Y 0.374 Neutral MSH6 P52701 K334A 334 K A 0.028 Neutral MSH6 P52701 K334C 334 K C 0.028 Neutral MSH6 P52701 K334D 334 K D 0.066 Neutral MSH6 P52701 K334E 334 K E 0.03 Neutral MSH6 P52701 K334F 334 K F 0.036 Neutral MSH6 P52701 K334G 334 K G 0.042 Neutral MSH6 P52701 K334H 334 K H 0.048 Neutral MSH6 P52701 K334I 334 K I 0.212 Neutral MSH6 P52701 K334L 334 K L 0.166 Neutral MSH6 P52701 K334M 334 K M 0.04 Neutral MSH6 P52701 K334N 334 K N 0.014 Neutral MSH6 P52701 K334P 334 K P 0.232 Neutral MSH6 P52701 K334Q 334 K Q 0.006 Neutral MSH6 P52701 K334R 334 K R 0.002 Neutral MSH6 P52701 K334S 334 K S 0.012 Neutral MSH6 P52701 K334T 334 K T 0.012 Neutral MSH6 P52701 K334V 334 K V 0.198 Neutral MSH6 P52701 K334W 334 K W 0.454 Neutral MSH6 P52701 K334Y 334 K Y 0.368 Neutral MSH6 P52701 N335A 335 N A 0.004 Neutral MSH6 P52701 N335C 335 N C 0.152 Neutral MSH6 P52701 N335D 335 N D 0.086 Neutral MSH6 P52701 N335E 335 N E 0.086 Neutral MSH6 P52701 N335F 335 N F 0.368 Neutral MSH6 P52701 N335G 335 N G 0.1 Neutral MSH6 P52701 N335H 335 N H 0.236 Neutral MSH6 P52701 N335I 335 N I 0.24 Neutral MSH6 P52701 N335K 335 N K 0.038 Neutral MSH6 P52701 N335L 335 N L 0.084 Neutral MSH6 P52701 N335M 335 N M 0.23 Neutral MSH6 P52701 N335P 335 N P 0.134 Neutral MSH6 P52701 N335Q 335 N Q 0.116 Neutral MSH6 P52701 N335R 335 N R 0.16 Neutral MSH6 P52701 N335S 335 N S 0.006 Neutral MSH6 P52701 N335T 335 N T 0.006 Neutral MSH6 P52701 N335V 335 N V 0.064 Neutral MSH6 P52701 N335W 335 N W 0.486 Neutral MSH6 P52701 N335Y 335 N Y 0.46 Neutral MSH6 P52701 T336A 336 T A 0 Neutral MSH6 P52701 T336C 336 T C 0.034 Neutral MSH6 P52701 T336D 336 T D 0.046 Neutral MSH6 P52701 T336E 336 T E 0.024 Neutral MSH6 P52701 T336F 336 T F 0.204 Neutral MSH6 P52701 T336G 336 T G 0.014 Neutral MSH6 P52701 T336H 336 T H 0.084 Neutral MSH6 P52701 T336I 336 T I 0.076 Neutral MSH6 P52701 T336K 336 T K 0.002 Neutral MSH6 P52701 T336L 336 T L 0.07 Neutral MSH6 P52701 T336M 336 T M 0.098 Neutral MSH6 P52701 T336N 336 T N 0 Neutral MSH6 P52701 T336P 336 T P 0.02 Neutral MSH6 P52701 T336Q 336 T Q 0.016 Neutral MSH6 P52701 T336R 336 T R 0.156 Neutral MSH6 P52701 T336S 336 T S 0 Neutral MSH6 P52701 T336V 336 T V 0.016 Neutral MSH6 P52701 T336W 336 T W 0.466 Neutral MSH6 P52701 T336Y 336 T Y 0.424 Neutral MSH6 P52701 L337A 337 L A 0.076 Neutral MSH6 P52701 L337C 337 L C 0.076 Neutral MSH6 P52701 L337D 337 L D 0.23 Neutral MSH6 P52701 L337E 337 L E 0.094 Neutral MSH6 P52701 L337F 337 L F 0.364 Neutral MSH6 P52701 L337G 337 L G 0.168 Neutral MSH6 P52701 L337H 337 L H 0.128 Neutral MSH6 P52701 L337I 337 L I 0.044 Neutral MSH6 P52701 L337K 337 L K 0.038 Neutral MSH6 P52701 L337M 337 L M 0.04 Neutral MSH6 P52701 L337N 337 L N 0.234 Neutral MSH6 P52701 L337P 337 L P 0.112 Neutral MSH6 P52701 L337Q 337 L Q 0.08 Neutral MSH6 P52701 L337R 337 L R 0.368 Neutral MSH6 P52701 L337S 337 L S 0.022 Neutral MSH6 P52701 L337T 337 L T 0.024 Neutral MSH6 P52701 L337V 337 L V 0.006 Neutral MSH6 P52701 L337W 337 L W 0.53 Pathogenic MSH6 P52701 L337Y 337 L Y 0.488 Neutral MSH6 P52701 R338A 338 R A 0.036 Neutral MSH6 P52701 R338C 338 R C 0.078 Neutral MSH6 P52701 R338D 338 R D 0.024 Neutral MSH6 P52701 R338E 338 R E 0.168 Neutral MSH6 P52701 R338F 338 R F 0.078 Neutral MSH6 P52701 R338G 338 R G 0.1 Neutral MSH6 P52701 R338H 338 R H 0.122 Neutral MSH6 P52701 R338I 338 R I 0.332 Neutral MSH6 P52701 R338K 338 R K 0.174 Neutral MSH6 P52701 R338L 338 R L 0.07 Neutral MSH6 P52701 R338M 338 R M 0.164 Neutral MSH6 P52701 R338N 338 R N 0.01 Neutral MSH6 P52701 R338P 338 R P 0.036 Neutral MSH6 P52701 R338Q 338 R Q 0.252 Neutral MSH6 P52701 R338S 338 R S 0.02 Neutral MSH6 P52701 R338T 338 R T 0.018 Neutral MSH6 P52701 R338V 338 R V 0.034 Neutral MSH6 P52701 R338W 338 R W 0.42 Neutral MSH6 P52701 R338Y 338 R Y 0.302 Neutral MSH6 P52701 A339C 339 A C 0.156 Neutral MSH6 P52701 A339D 339 A D 0.316 Neutral MSH6 P52701 A339E 339 A E 0.288 Neutral MSH6 P52701 A339F 339 A F 0.468 Neutral MSH6 P52701 A339G 339 A G 0.022 Neutral MSH6 P52701 A339H 339 A H 0.304 Neutral MSH6 P52701 A339I 339 A I 0.356 Neutral MSH6 P52701 A339K 339 A K 0.268 Neutral MSH6 P52701 A339L 339 A L 0.318 Neutral MSH6 P52701 A339M 339 A M 0.266 Neutral MSH6 P52701 A339N 339 A N 0.306 Neutral MSH6 P52701 A339P 339 A P 0.3 Neutral MSH6 P52701 A339Q 339 A Q 0.264 Neutral MSH6 P52701 A339R 339 A R 0.286 Neutral MSH6 P52701 A339S 339 A S 0.006 Neutral MSH6 P52701 A339T 339 A T 0.014 Neutral MSH6 P52701 A339V 339 A V 0.074 Neutral MSH6 P52701 A339W 339 A W 0.504 Pathogenic MSH6 P52701 A339Y 339 A Y 0.5 Pathogenic MSH6 P52701 A34C 34 A C 0.182 Neutral MSH6 P52701 A34D 34 A D 0.348 Neutral MSH6 P52701 A34E 34 A E 0.306 Neutral MSH6 P52701 A34F 34 A F 0.468 Neutral MSH6 P52701 A34G 34 A G 0.074 Neutral MSH6 P52701 A34H 34 A H 0.304 Neutral MSH6 P52701 A34I 34 A I 0.406 Neutral MSH6 P52701 A34K 34 A K 0.354 Neutral MSH6 P52701 A34L 34 A L 0.4 Neutral MSH6 P52701 A34M 34 A M 0.29 Neutral MSH6 P52701 A34N 34 A N 0.296 Neutral MSH6 P52701 A34P 34 A P 0.272 Neutral MSH6 P52701 A34Q 34 A Q 0.302 Neutral MSH6 P52701 A34R 34 A R 0.318 Neutral MSH6 P52701 A34S 34 A S 0.068 Neutral MSH6 P52701 A34T 34 A T 0.166 Neutral MSH6 P52701 A34V 34 A V 0.202 Neutral MSH6 P52701 A34W 34 A W 0.504 Pathogenic MSH6 P52701 A34Y 34 A Y 0.5 Pathogenic MSH6 P52701 F340A 340 F A 0.046 Neutral MSH6 P52701 F340C 340 F C 0.088 Neutral MSH6 P52701 F340D 340 F D 0.176 Neutral MSH6 P52701 F340E 340 F E 0.05 Neutral MSH6 P52701 F340G 340 F G 0.046 Neutral MSH6 P52701 F340H 340 F H 0.046 Neutral MSH6 P52701 F340I 340 F I 0.054 Neutral MSH6 P52701 F340K 340 F K 0.048 Neutral MSH6 P52701 F340L 340 F L 0.06 Neutral MSH6 P52701 F340M 340 F M 0.086 Neutral MSH6 P52701 F340N 340 F N 0.052 Neutral MSH6 P52701 F340P 340 F P 0.032 Neutral MSH6 P52701 F340Q 340 F Q 0.042 Neutral MSH6 P52701 F340R 340 F R 0.156 Neutral MSH6 P52701 F340S 340 F S 0.014 Neutral 2 MSH6 P52701 F340T 340 F T 0.014 Neutral MSH6 P52701 F340V 340 F V 0.092 Neutral MSH6 P52701 F340W 340 F W 0.348 Neutral MSH6 P52701 F340Y 340 F Y 0.16 Neutral MSH6 P52701 S341A 341 S A 0.01 Neutral MSH6 P52701 S341C 341 S C 0.032 Neutral MSH6 P52701 S341D 341 S D 0.026 Neutral MSH6 P52701 S341E 341 S E 0.138 Neutral MSH6 P52701 S341F 341 S F 0.308 Neutral MSH6 P52701 S341G 341 S G 0.036 Neutral MSH6 P52701 S341H 341 S H 0.264 Neutral MSH6 P52701 S341I 341 S I 0.142 Neutral MSH6 P52701 S341K 341 S K 0.17 Neutral MSH6 P52701 S341L 341 S L 0.052 Neutral MSH6 P52701 S341M 341 S M 0.302 Neutral MSH6 P52701 S341N 341 S N 0.004 Neutral MSH6 P52701 S341P 341 S P 0.07 Neutral MSH6 P52701 S341Q 341 S Q 0.18 Neutral MSH6 P52701 S341R 341 S R 0.162 Neutral MSH6 P52701 S341T 341 S T 0.02 Neutral MSH6 P52701 S341V 341 S V 0.138 Neutral MSH6 P52701 S341W 341 S W 0.444 Neutral MSH6 P52701 S341Y 341 S Y 0.488 Neutral MSH6 P52701 A342C 342 A C 0.322 Neutral MSH6 P52701 A342D 342 A D 0.518 Pathogenic MSH6 P52701 A342E 342 A E 0.39 Neutral MSH6 P52701 A342F 342 A F 0.644 Pathogenic MSH6 P52701 A342G 342 A G 0.22 Neutral MSH6 P52701 A342H 342 A H 0.5 Pathogenic MSH6 P52701 A342I 342 A I 0.698 Pathogenic MSH6 P52701 A342K 342 A K 0.37 Neutral MSH6 P52701 A342L 342 A L 0.642 Pathogenic MSH6 P52701 A342M 342 A M 0.486 Neutral MSH6 P52701 A342N 342 A N 0.402 Neutral MSH6 P52701 A342P 342 A P 0.068 Neutral MSH6 P52701 A342Q 342 A Q 0.464 Neutral MSH6 P52701 A342R 342 A R 0.388 Neutral MSH6 P52701 A342S 342 A S 0.012 Neutral MSH6 P52701 A342T 342 A T 0.03 Neutral MSH6 P52701 A342V 342 A V 0.11 Neutral MSH6 P52701 A342W 342 A W 0.716 Pathogenic MSH6 P52701 A342Y 342 A Y 0.724 Pathogenic MSH6 P52701 P343A 343 P A 0.032 Neutral MSH6 P52701 P343C 343 P C 0.148 Neutral MSH6 P52701 P343D 343 P D 0.05 Neutral MSH6 P52701 P343E 343 P E 0.106 Neutral MSH6 P52701 P343F 343 P F 0.272 Neutral MSH6 P52701 P343G 343 P G 0.024 Neutral MSH6 P52701 P343H 343 P H 0.226 Neutral MSH6 P52701 P343I 343 P I 0.054 Neutral MSH6 P52701 P343K 343 P K 0.054 Neutral MSH6 P52701 P343L 343 P L 0.096 Neutral MSH6 P52701 P343M 343 P M 0.146 Neutral MSH6 P52701 P343N 343 P N 0.004 Neutral MSH6 P52701 P343Q 343 P Q 0.06 Neutral MSH6 P52701 P343R 343 P R 0.202 Neutral MSH6 P52701 P343S 343 P S 0.002 Neutral MSH6 P52701 P343T 343 P T 0.012 Neutral MSH6 P52701 P343V 343 P V 0.07 Neutral MSH6 P52701 P343W 343 P W 0.328 Neutral MSH6 P52701 P343Y 343 P Y 0.234 Neutral MSH6 P52701 Q344A 344 Q A 0.076 Neutral MSH6 P52701 Q344C 344 Q C 0.082 Neutral MSH6 P52701 Q344D 344 Q D 0 Neutral MSH6 P52701 Q344E 344 Q E 0.006 Neutral MSH6 P52701 Q344F 344 Q F 0.362 Neutral MSH6 P52701 Q344G 344 Q G 0.054 Neutral MSH6 P52701 Q344H 344 Q H 0.262 Neutral MSH6 P52701 Q344I 344 Q I 0.228 Neutral MSH6 P52701 Q344K 344 Q K 0.02 Neutral MSH6 P52701 Q344L 344 Q L 0.214 Neutral MSH6 P52701 Q344M 344 Q M 0.21 Neutral MSH6 P52701 Q344N 344 Q N 0.082 Neutral MSH6 P52701 Q344P 344 Q P 0.22 Neutral MSH6 P52701 Q344R 344 Q R 0.002 Neutral MSH6 P52701 Q344S 344 Q S 0.112 Neutral MSH6 P52701 Q344T 344 Q T 0.002 Neutral MSH6 P52701 Q344V 344 Q V 0.012 Neutral MSH6 P52701 Q344W 344 Q W 0.432 Neutral MSH6 P52701 Q344Y 344 Q Y 0.362 Neutral MSH6 P52701 N345A 345 N A 0.004 Neutral MSH6 P52701 N345C 345 N C 0.034 Neutral MSH6 P52701 N345D 345 N D 0.118 Neutral MSH6 P52701 N345E 345 N E 0.096 Neutral MSH6 P52701 N345F 345 N F 0.418 Neutral MSH6 P52701 N345G 345 N G 0.02 Neutral MSH6 P52701 N345H 345 N H 0.02 Neutral MSH6 P52701 N345I 345 N I 0.248 Neutral MSH6 P52701 N345K 345 N K 0.148 Neutral MSH6 P52701 N345L 345 N L 0.172 Neutral MSH6 P52701 N345M 345 N M 0.22 Neutral MSH6 P52701 N345P 345 N P 0.132 Neutral MSH6 P52701 N345Q 345 N Q 0.166 Neutral MSH6 P52701 N345R 345 N R 0.148 Neutral MSH6 P52701 N345S 345 N S 0 Neutral MSH6 P52701 N345T 345 N T 0.006 Neutral MSH6 P52701 N345V 345 N V 0.12 Neutral MSH6 P52701 N345W 345 N W 0.446 Neutral MSH6 P52701 N345Y 345 N Y 0.45 Neutral MSH6 P52701 S346A 346 S A 0.01 Neutral MSH6 P52701 S346C 346 S C 0.022 Neutral MSH6 P52701 S346D 346 S D 0.024 Neutral MSH6 P52701 S346E 346 S E 0.124 Neutral MSH6 P52701 S346F 346 S F 0.26 Neutral MSH6 P52701 S346G 346 S G 0.036 Neutral MSH6 P52701 S346H 346 S H 0.238 Neutral MSH6 P52701 S346I 346 S I 0.17 Neutral MSH6 P52701 S346K 346 S K 0.164 Neutral MSH6 P52701 S346L 346 S L 0.026 Neutral MSH6 P52701 S346M 346 S M 0.266 Neutral MSH6 P52701 S346N 346 S N 0.018 Neutral MSH6 P52701 S346P 346 S P 0.062 Neutral MSH6 P52701 S346Q 346 S Q 0.17 Neutral MSH6 P52701 S346R 346 S R 0.17 Neutral MSH6 P52701 S346T 346 S T 0.02 Neutral MSH6 P52701 S346V 346 S V 0.034 Neutral MSH6 P52701 S346W 346 S W 0.49 Neutral MSH6 P52701 S346Y 346 S Y 0.434 Neutral MSH6 P52701 E347A 347 E A 0.066 Neutral MSH6 P52701 E347C 347 E C 0.078 Neutral MSH6 P52701 E347D 347 E D 0 Neutral MSH6 P52701 E347F 347 E F 0.332 Neutral MSH6 P52701 E347G 347 E G 0.002 Neutral MSH6 P52701 E347H 347 E H 0.122 Neutral MSH6 P52701 E347I 347 E I 0.346 Neutral MSH6 P52701 E347K 347 E K 0.028 Neutral MSH6 P52701 E347L 347 E L 0.346 Neutral MSH6 P52701 E347M 347 E M 0.2 Neutral MSH6 P52701 E347N 347 E N 0.002 Neutral MSH6 P52701 E347P 347 E P 0.08 Neutral MSH6 P52701 E347Q 347 E Q 0.064 Neutral MSH6 P52701 E347R 347 E R 0.018 Neutral MSH6 P52701 E347S 347 E S 0.016 Neutral MSH6 P52701 E347T 347 E T 0.008 Neutral MSH6 P52701 E347V 347 E V 0.038 Neutral MSH6 P52701 E347W 347 E W 0.552 Pathogenic MSH6 P52701 E347Y 347 E Y 0.452 Neutral MSH6 P52701 S348A 348 S A 0.012 Neutral MSH6 P52701 S348C 348 S C 0.022 Neutral MSH6 P52701 S348D 348 S D 0.026 Neutral MSH6 P52701 S348E 348 S E 0.136 Neutral MSH6 P52701 S348F 348 S F 0.288 Neutral MSH6 P52701 S348G 348 S G 0 Neutral MSH6 P52701 S348H 348 S H 0.264 Neutral MSH6 P52701 S348I 348 S I 0.036 Neutral MSH6 P52701 S348K 348 S K 0.174 Neutral MSH6 P52701 S348L 348 S L 0.052 Neutral MSH6 P52701 S348M 348 S M 0.384 Neutral MSH6 P52701 S348N 348 S N 0 Neutral MSH6 P52701 S348P 348 S P 0.072 Neutral MSH6 P52701 S348Q 348 S Q 0.156 Neutral MSH6 P52701 S348R 348 S R 0.168 Neutral MSH6 P52701 S348T 348 S T 0.046 Neutral MSH6 P52701 S348V 348 S V 0.138 Neutral MSH6 P52701 S348W 348 S W 0.532 Pathogenic MSH6 P52701 S348Y 348 S Y 0.482 Neutral MSH6 P52701 Q349A 349 Q A 0.036 Neutral MSH6 P52701 Q349C 349 Q C 0.082 Neutral MSH6 P52701 Q349D 349 Q D 0 Neutral MSH6 P52701 Q349E 349 Q E 0.008 Neutral MSH6 P52701 Q349F 349 Q F 0.268 Neutral MSH6 P52701 Q349G 349 Q G 0.106 Neutral MSH6 P52701 Q349H 349 Q H 0.216 Neutral MSH6 P52701 Q349I 349 Q I 0.364 Neutral MSH6 P52701 Q349K 349 Q K 0.02 Neutral MSH6 P52701 Q349L 349 Q L 0.116 Neutral MSH6 P52701 Q349M 349 Q M 0.188 Neutral MSH6 P52701 Q349N 349 Q N 0.082 Neutral MSH6 P52701 Q349P 349 Q P 0.224 Neutral MSH6 P52701 Q349R 349 Q R 0.002 Neutral MSH6 P52701 Q349S 349 Q S 0.112 Neutral MSH6 P52701 Q349T 349 Q T 0.014 Neutral MSH6 P52701 Q349V 349 Q V 0.016 Neutral MSH6 P52701 Q349W 349 Q W 0.432 Neutral MSH6 P52701 Q349Y 349 Q Y 0.38 Neutral MSH6 P52701 A35C 35 A C 0.182 Neutral MSH6 P52701 A35D 35 A D 0.316 Neutral MSH6 P52701 A35E 35 A E 0.306 Neutral MSH6 P52701 A35F 35 A F 0.468 Neutral MSH6 P52701 A35G 35 A G 0.004 Neutral MSH6 P52701 A35H 35 A H 0.304 Neutral MSH6 P52701 A35I 35 A I 0.406 Neutral MSH6 P52701 A35K 35 A K 0.354 Neutral MSH6 P52701 A35L 35 A L 0.318 Neutral MSH6 P52701 A35M 35 A M 0.29 Neutral MSH6 P52701 A35N 35 A N 0.274 Neutral MSH6 P52701 A35P 35 A P 0.3 Neutral MSH6 P52701 A35Q 35 A Q 0.286 Neutral MSH6 P52701 A35R 35 A R 0.326 Neutral MSH6 P52701 A35S 35 A S 0.156 Neutral MSH6 P52701 A35T 35 A T 0.166 Neutral MSH6 P52701 A35V 35 A V 0.202 Neutral MSH6 P52701 A35W 35 A W 0.504 Pathogenic MSH6 P52701 A35Y 35 A Y 0.5 Pathogenic MSH6 P52701 A350C 350 A C 0.212 Neutral MSH6 P52701 A350D 350 A D 0.342 Neutral MSH6 P52701 A350E 350 A E 0.276 Neutral MSH6 P52701 A350F 350 A F 0.408 Neutral MSH6 P52701 A350G 350 A G 0.022 Neutral MSH6 P52701 A350H 350 A H 0.224 Neutral MSH6 P52701 A350I 350 A I 0.406 Neutral MSH6 P52701 A350K 350 A K 0.268 Neutral MSH6 P52701 A350L 350 A L 0.302 Neutral MSH6 P52701 A350M 350 A M 0.29 Neutral MSH6 P52701 A350N 350 A N 0.31 Neutral MSH6 P52701 A350P 350 A P 0.044 Neutral MSH6 P52701 A350Q 350 A Q 0.286 Neutral MSH6 P52701 A350R 350 A R 0.326 Neutral MSH6 P52701 A350S 350 A S 0.006 Neutral MSH6 P52701 A350T 350 A T 0.018 Neutral MSH6 P52701 A350V 350 A V 0.136 Neutral MSH6 P52701 A350W 350 A W 0.504 Pathogenic MSH6 P52701 A350Y 350 A Y 0.5 Pathogenic MSH6 P52701 H351A 351 H A 0.042 Neutral MSH6 P52701 H351C 351 H C 0.028 Neutral MSH6 P52701 H351D 351 H D 0 Neutral MSH6 P52701 H351E 351 H E 0.058 Neutral MSH6 P52701 H351F 351 H F 0.204 Neutral MSH6 P52701 H351G 351 H G 0.04 Neutral MSH6 P52701 H351I 351 H I 0.258 Neutral MSH6 P52701 H351K 351 H K 0.004 Neutral MSH6 P52701 H351L 351 H L 0.044 Neutral MSH6 P52701 H351M 351 H M 0.108 Neutral MSH6 P52701 H351N 351 H N 0.002 Neutral MSH6 P52701 H351P 351 H P 0.026 Neutral MSH6 P52701 H351Q 351 H Q 0.006 Neutral MSH6 P52701 H351R 351 H R 0.002 Neutral MSH6 P52701 H351S 351 H S 0.012 Neutral MSH6 P52701 H351T 351 H T 0.008 Neutral MSH6 P52701 H351V 351 H V 0.016 Neutral MSH6 P52701 H351W 351 H W 0.398 Neutral MSH6 P52701 H351Y 351 H Y 0.252 Neutral MSH6 P52701 V352A 352 V A 0 Neutral MSH6 P52701 V352C 352 V C 0.058 Neutral MSH6 P52701 V352D 352 V D 0.032 Neutral MSH6 P52701 V352E 352 V E 0.052 Neutral MSH6 P52701 V352F 352 V F 0.166 Neutral MSH6 P52701 V352G 352 V G 0.038 Neutral MSH6 P52701 V352H 352 V H 0.05 Neutral MSH6 P52701 V352I 352 V I 0.008 Neutral MSH6 P52701 V352K 352 V K 0.174 Neutral MSH6 P52701 V352L 352 V L 0.018 Neutral MSH6 P52701 V352M 352 V M 0.048 Neutral MSH6 P52701 V352N 352 V N 0.154 Neutral MSH6 P52701 V352P 352 V P 0.046 Neutral MSH6 P52701 V352Q 352 V Q 0.07 Neutral MSH6 P52701 V352R 352 V R 0.264 Neutral MSH6 P52701 V352S 352 V S 0.026 Neutral MSH6 P52701 V352T 352 V T 0.008 Neutral MSH6 P52701 V352W 352 V W 0.374 Neutral MSH6 P52701 V352Y 352 V Y 0.154 Neutral MSH6 P52701 S353A 353 S A 0.01 Neutral MSH6 P52701 S353C 353 S C 0.002 Neutral MSH6 P52701 S353D 353 S D 0.002 Neutral MSH6 P52701 S353E 353 S E 0.146 Neutral MSH6 P52701 S353F 353 S F 0.308 Neutral MSH6 P52701 S353G 353 S G 0 Neutral MSH6 P52701 S353H 353 S H 0.19 Neutral MSH6 P52701 S353I 353 S I 0.206 Neutral MSH6 P52701 S353K 353 S K 0.174 Neutral MSH6 P52701 S353L 353 S L 0.086 Neutral MSH6 P52701 S353M 353 S M 0.384 Neutral MSH6 P52701 S353N 353 S N 0 Neutral MSH6 P52701 S353P 353 S P 0.062 Neutral MSH6 P52701 S353Q 353 S Q 0.156 Neutral MSH6 P52701 S353R 353 S R 0.168 Neutral MSH6 P52701 S353T 353 S T 0.104 Neutral MSH6 P52701 S353V 353 S V 0.302 Neutral MSH6 P52701 S353W 353 S W 0.532 Pathogenic MSH6 P52701 S353Y 353 S Y 0.488 Neutral MSH6 P52701 G354A 354 G A 0.006 Neutral MSH6 P52701 G354C 354 G C 0.284 Neutral MSH6 P52701 G354D 354 G D 0.19 Neutral MSH6 P52701 G354E 354 G E 0.28 Neutral MSH6 P52701 G354F 354 G F 0.648 Pathogenic MSH6 P52701 G354H 354 G H 0.602 Pathogenic MSH6 P52701 G354I 354 G I 0.606 Pathogenic MSH6 P52701 G354K 354 G K 0.384 Neutral MSH6 P52701 G354L 354 G L 0.408 Neutral MSH6 P52701 G354M 354 G M 0.592 Pathogenic MSH6 P52701 G354N 354 G N 0.252 Neutral MSH6 P52701 G354P 354 G P 0.444 Neutral MSH6 P52701 G354Q 354 G Q 0.29 Neutral MSH6 P52701 G354R 354 G R 0.532 Pathogenic MSH6 P52701 G354S 354 G S 0.024 Neutral MSH6 P52701 G354T 354 G T 0.406 Neutral MSH6 P52701 G354V 354 G V 0.416 Neutral MSH6 P52701 G354W 354 G W 0.658 Pathogenic MSH6 P52701 G354Y 354 G Y 0.652 Pathogenic MSH6 P52701 G355A 355 G A 0.002 Neutral MSH6 P52701 G355C 355 G C 0.14 Neutral MSH6 P52701 G355D 355 G D 0.138 Neutral MSH6 P52701 G355E 355 G E 0.192 Neutral MSH6 P52701 G355F 355 G F 0.422 Neutral MSH6 P52701 G355H 355 G H 0.442 Neutral MSH6 P52701 G355I 355 G I 0.412 Neutral MSH6 P52701 G355K 355 G K 0.284 Neutral MSH6 P52701 G355L 355 G L 0.328 Neutral MSH6 P52701 G355M 355 G M 0.34 Neutral MSH6 P52701 G355N 355 G N 0.168 Neutral MSH6 P52701 G355P 355 G P 0.442 Neutral MSH6 P52701 G355Q 355 G Q 0.208 Neutral MSH6 P52701 G355R 355 G R 0.362 Neutral MSH6 P52701 G355S 355 G S 0.016 Neutral MSH6 P52701 G355T 355 G T 0.266 Neutral MSH6 P52701 G355V 355 G V 0.32 Neutral MSH6 P52701 G355W 355 G W 0.498 Neutral MSH6 P52701 G355Y 355 G Y 0.5 Pathogenic MSH6 P52701 G356A 356 G A 0.002 Neutral MSH6 P52701 G356C 356 G C 0.19 Neutral MSH6 P52701 G356D 356 G D 0.118 Neutral MSH6 P52701 G356E 356 G E 0.196 Neutral MSH6 P52701 G356F 356 G F 0.516 Pathogenic MSH6 P52701 G356H 356 G H 0.46 Neutral MSH6 P52701 G356I 356 G I 0.454 Neutral MSH6 P52701 G356K 356 G K 0.292 Neutral MSH6 P52701 G356L 356 G L 0.438 Neutral MSH6 P52701 G356M 356 G M 0.44 Neutral MSH6 P52701 G356N 356 G N 0.162 Neutral MSH6 P52701 G356P 356 G P 0.456 Neutral MSH6 P52701 G356Q 356 G Q 0.19 Neutral MSH6 P52701 G356R 356 G R 0.306 Neutral MSH6 P52701 G356S 356 G S 0.02 Neutral MSH6 P52701 G356T 356 G T 0.264 Neutral MSH6 P52701 G356V 356 G V 0.328 Neutral MSH6 P52701 G356W 356 G W 0.516 Pathogenic MSH6 P52701 G356Y 356 G Y 0.512 Pathogenic MSH6 P52701 D357A 357 D A 0.014 Neutral MSH6 P52701 D357C 357 D C 0.148 Neutral MSH6 P52701 D357E 357 D E 0.014 Neutral MSH6 P52701 D357F 357 D F 0.37 Neutral MSH6 P52701 D357G 357 D G 0.018 Neutral MSH6 P52701 D357H 357 D H 0.154 Neutral MSH6 P52701 D357I 357 D I 0.116 Neutral MSH6 P52701 D357K 357 D K 0.21 Neutral MSH6 P52701 D357L 357 D L 0.028 Neutral MSH6 P52701 D357M 357 D M 0.106 Neutral MSH6 P52701 D357N 357 D N 0 Neutral MSH6 P52701 D357P 357 D P 0.144 Neutral MSH6 P52701 D357Q 357 D Q 0.032 Neutral MSH6 P52701 D357R 357 D R 0.166 Neutral MSH6 P52701 D357S 357 D S 0.002 Neutral MSH6 P52701 D357T 357 D T 0.012 Neutral MSH6 P52701 D357V 357 D V 0.188 Neutral MSH6 P52701 D357W 357 D W 0.434 Neutral MSH6 P52701 D357Y 357 D Y 0.404 Neutral MSH6 P52701 D358A 358 D A 0.1 Neutral MSH6 P52701 D358C 358 D C 0.148 Neutral MSH6 P52701 D358E 358 D E 0.014 Neutral MSH6 P52701 D358F 358 D F 0.406 Neutral MSH6 P52701 D358G 358 D G 0.018 Neutral MSH6 P52701 D358H 358 D H 0.154 Neutral MSH6 P52701 D358I 358 D I 0.262 Neutral MSH6 P52701 D358K 358 D K 0.21 Neutral MSH6 P52701 D358L 358 D L 0.256 Neutral MSH6 P52701 D358M 358 D M 0.19 Neutral MSH6 P52701 D358N 358 D N 0 Neutral MSH6 P52701 D358P 358 D P 0.31 Neutral MSH6 P52701 D358Q 358 D Q 0.172 Neutral MSH6 P52701 D358R 358 D R 0.166 Neutral MSH6 P52701 D358S 358 D S 0.002 Neutral MSH6 P52701 D358T 358 D T 0.154 Neutral MSH6 P52701 D358V 358 D V 0.242 Neutral MSH6 P52701 D358W 358 D W 0.434 Neutral MSH6 P52701 D358Y 358 D Y 0.404 Neutral MSH6 P52701 S359A 359 S A 0.012 Neutral MSH6 P52701 S359C 359 S C 0.032 Neutral MSH6 P52701 S359D 359 S D 0.024 Neutral MSH6 P52701 S359E 359 S E 0.138 Neutral MSH6 P52701 S359F 359 S F 0.276 Neutral MSH6 P52701 S359G 359 S G 0 Neutral MSH6 P52701 S359H 359 S H 0.238 Neutral MSH6 P52701 S359I 359 S I 0.17 Neutral MSH6 P52701 S359K 359 S K 0.15 Neutral MSH6 P52701 S359L 359 S L 0.034 Neutral MSH6 P52701 S359M 359 S M 0.332 Neutral MSH6 P52701 S359N 359 S N 0 Neutral MSH6 P52701 S359P 359 S P 0.116 Neutral MSH6 P52701 S359Q 359 S Q 0.172 Neutral MSH6 P52701 S359R 359 S R 0.248 Neutral MSH6 P52701 S359T 359 S T 0.02 Neutral MSH6 P52701 S359V 359 S V 0.288 Neutral MSH6 P52701 S359W 359 S W 0.49 Neutral MSH6 P52701 S359Y 359 S Y 0.448 Neutral MSH6 P52701 A36C 36 A C 0.212 Neutral MSH6 P52701 A36D 36 A D 0.266 Neutral MSH6 P52701 A36E 36 A E 0.306 Neutral MSH6 P52701 A36F 36 A F 0.468 Neutral MSH6 P52701 A36G 36 A G 0.12 Neutral MSH6 P52701 A36H 36 A H 0.304 Neutral MSH6 P52701 A36I 36 A I 0.406 Neutral MSH6 P52701 A36K 36 A K 0.252 Neutral MSH6 P52701 A36L 36 A L 0.4 Neutral MSH6 P52701 A36M 36 A M 0.29 Neutral MSH6 P52701 A36N 36 A N 0.274 Neutral MSH6 P52701 A36P 36 A P 0.036 Neutral MSH6 P52701 A36Q 36 A Q 0.302 Neutral MSH6 P52701 A36R 36 A R 0.326 Neutral MSH6 P52701 A36S 36 A S 0.156 Neutral MSH6 P52701 A36T 36 A T 0.014 Neutral MSH6 P52701 A36V 36 A V 0.202 Neutral MSH6 P52701 A36W 36 A W 0.504 Pathogenic MSH6 P52701 A36Y 36 A Y 0.5 Pathogenic MSH6 P52701 S360A 360 S A 0.01 Neutral MSH6 P52701 S360C 360 S C 0.008 Neutral MSH6 P52701 S360D 360 S D 0.004 Neutral MSH6 P52701 S360E 360 S E 0.122 Neutral MSH6 P52701 S360F 360 S F 0.25 Neutral MSH6 P52701 S360G 360 S G 0 Neutral MSH6 P52701 S360H 360 S H 0.188 Neutral MSH6 P52701 S360I 360 S I 0.026 Neutral MSH6 P52701 S360K 360 S K 0.164 Neutral MSH6 P52701 S360L 360 S L 0.068 Neutral MSH6 P52701 S360M 360 S M 0.252 Neutral MSH6 P52701 S360N 360 S N 0 Neutral MSH6 P52701 S360P 360 S P 0.116 Neutral MSH6 P52701 S360Q 360 S Q 0.158 Neutral MSH6 P52701 S360R 360 S R 0.136 Neutral MSH6 P52701 S360T 360 S T 0.046 Neutral MSH6 P52701 S360V 360 S V 0.288 Neutral MSH6 P52701 S360W 360 S W 0.49 Neutral MSH6 P52701 S360Y 360 S Y 0.448 Neutral MSH6 P52701 R361A 361 R A 0.08 Neutral MSH6 P52701 R361C 361 R C 0.148 Neutral MSH6 P52701 R361D 361 R D 0.02 Neutral MSH6 P52701 R361E 361 R E 0.022 Neutral MSH6 P52701 R361F 361 R F 0.066 Neutral MSH6 P52701 R361G 361 R G 0.002 Neutral MSH6 P52701 R361H 361 R H 0.142 Neutral MSH6 P52701 R361I 361 R I 0.304 Neutral MSH6 P52701 R361K 361 R K 0.004 Neutral MSH6 P52701 R361L 361 R L 0.272 Neutral MSH6 P52701 R361M 361 R M 0.164 Neutral MSH6 P52701 R361N 361 R N 0.01 Neutral MSH6 P52701 R361P 361 R P 0.106 Neutral MSH6 P52701 R361Q 361 R Q 0.012 Neutral MSH6 P52701 R361S 361 R S 0.02 Neutral MSH6 P52701 R361T 361 R T 0.142 Neutral MSH6 P52701 R361V 361 R V 0.242 Neutral MSH6 P52701 R361W 361 R W 0.384 Neutral MSH6 P52701 R361Y 361 R Y 0.182 Neutral MSH6 P52701 P362A 362 P A 0.036 Neutral MSH6 P52701 P362C 362 P C 0.158 Neutral MSH6 P52701 P362D 362 P D 0.08 Neutral MSH6 P52701 P362E 362 P E 0.122 Neutral MSH6 P52701 P362F 362 P F 0.326 Neutral MSH6 P52701 P362G 362 P G 0.07 Neutral MSH6 P52701 P362H 362 P H 0.276 Neutral MSH6 P52701 P362I 362 P I 0.098 Neutral MSH6 P52701 P362K 362 P K 0.062 Neutral MSH6 P52701 P362L 362 P L 0.062 Neutral MSH6 P52701 P362M 362 P M 0.254 Neutral MSH6 P52701 P362N 362 P N 0.068 Neutral MSH6 P52701 P362Q 362 P Q 0.182 Neutral MSH6 P52701 P362R 362 P R 0.356 Neutral MSH6 P52701 P362S 362 P S 0.002 Neutral MSH6 P52701 P362T 362 P T 0.192 Neutral MSH6 P52701 P362V 362 P V 0.196 Neutral MSH6 P52701 P362W 362 P W 0.438 Neutral MSH6 P52701 P362Y 362 P Y 0.322 Neutral MSH6 P52701 T363A 363 T A 0 Neutral MSH6 P52701 T363C 363 T C 0.064 Neutral MSH6 P52701 T363D 363 T D 0.038 Neutral MSH6 P52701 T363E 363 T E 0.024 Neutral MSH6 P52701 T363F 363 T F 0.194 Neutral MSH6 P52701 T363G 363 T G 0.002 Neutral MSH6 P52701 T363H 363 T H 0.084 Neutral MSH6 P52701 T363I 363 T I 0.066 Neutral MSH6 P52701 T363K 363 T K 0.042 Neutral MSH6 P52701 T363L 363 T L 0.07 Neutral MSH6 P52701 T363M 363 T M 0.098 Neutral MSH6 P52701 T363N 363 T N 0.02 Neutral MSH6 P52701 T363P 363 T P 0.1 Neutral MSH6 P52701 T363Q 363 T Q 0.052 Neutral MSH6 P52701 T363R 363 T R 0.14 Neutral MSH6 P52701 T363S 363 T S 0 Neutral MSH6 P52701 T363V 363 T V 0.016 Neutral MSH6 P52701 T363W 363 T W 0.466 Neutral MSH6 P52701 T363Y 363 T Y 0.424 Neutral MSH6 P52701 V364A 364 V A 0 Neutral MSH6 P52701 V364C 364 V C 0.058 Neutral MSH6 P52701 V364D 364 V D 0.122 Neutral MSH6 P52701 V364E 364 V E 0.098 Neutral MSH6 P52701 V364F 364 V F 0.172 Neutral MSH6 P52701 V364G 364 V G 0.118 Neutral MSH6 P52701 V364H 364 V H 0.068 Neutral MSH6 P52701 V364I 364 V I 0.004 Neutral MSH6 P52701 V364K 364 V K 0.138 Neutral MSH6 P52701 V364L 364 V L 0.004 Neutral MSH6 P52701 V364M 364 V M 0.034 Neutral MSH6 P52701 V364N 364 V N 0.088 Neutral MSH6 P52701 V364P 364 V P 0.19 Neutral MSH6 P52701 V364Q 364 V Q 0.06 Neutral MSH6 P52701 V364R 364 V R 0.228 Neutral MSH6 P52701 V364S 364 V S 0.012 Neutral MSH6 P52701 V364T 364 V T 0.008 Neutral MSH6 P52701 V364W 364 V W 0.344 Neutral MSH6 P52701 V364Y 364 V Y 0.256 Neutral MSH6 P52701 W365A 365 W A 0.25 Neutral MSH6 P52701 W365C 365 W C 0.25 Neutral MSH6 P52701 W365D 365 W D 0.374 Neutral MSH6 P52701 W365E 365 W E 0.492 Neutral MSH6 P52701 W365F 365 W F 0.04 Neutral MSH6 P52701 W365G 365 W G 0.274 Neutral MSH6 P52701 W365H 365 W H 0.124 Neutral MSH6 P52701 W365I 365 W I 0.262 Neutral MSH6 P52701 W365K 365 W K 0.488 Neutral MSH6 P52701 W365L 365 W L 0.24 Neutral MSH6 P52701 W365M 365 W M 0.27 Neutral MSH6 P52701 W365N 365 W N 0.276 Neutral MSH6 P52701 W365P 365 W P 0.328 Neutral MSH6 P52701 W365Q 365 W Q 0.284 Neutral MSH6 P52701 W365R 365 W R 0.496 Neutral MSH6 P52701 W365S 365 W S 0.262 Neutral MSH6 P52701 W365T 365 W T 0.25 Neutral MSH6 P52701 W365V 365 W V 0.314 Neutral MSH6 P52701 W365Y 365 W Y 0.05 Neutral MSH6 P52701 Y366A 366 Y A 0.046 Neutral MSH6 P52701 Y366C 366 Y C 0.112 Neutral MSH6 P52701 Y366D 366 Y D 0.032 Neutral MSH6 P52701 Y366E 366 Y E 0.032 Neutral MSH6 P52701 Y366F 366 Y F 0.036 Neutral MSH6 P52701 Y366G 366 Y G 0.122 Neutral MSH6 P52701 Y366H 366 Y H 0.054 Neutral MSH6 P52701 Y366I 366 Y I 0.016 Neutral MSH6 P52701 Y366K 366 Y K 0.14 Neutral MSH6 P52701 Y366L 366 Y L 0.012 Neutral MSH6 P52701 Y366M 366 Y M 0.07 Neutral MSH6 P52701 Y366N 366 Y N 0.116 Neutral MSH6 P52701 Y366P 366 Y P 0.032 Neutral MSH6 P52701 Y366Q 366 Y Q 0.134 Neutral MSH6 P52701 Y366R 366 Y R 0.156 Neutral MSH6 P52701 Y366S 366 Y S 0.158 Neutral MSH6 P52701 Y366T 366 Y T 0.078 Neutral MSH6 P52701 Y366V 366 Y V 0.03 Neutral MSH6 P52701 Y366W 366 Y W 0.048 Neutral MSH6 P52701 H367A 367 H A 0.346 Neutral MSH6 P52701 H367C 367 H C 0.274 Neutral MSH6 P52701 H367D 367 H D 0.246 Neutral MSH6 P52701 H367E 367 H E 0.136 Neutral MSH6 P52701 H367F 367 H F 0.766 Pathogenic MSH6 P52701 H367G 367 H G 0.31 Neutral MSH6 P52701 H367I 367 H I 0.786 Pathogenic MSH6 P52701 H367K 367 H K 0.616 Pathogenic MSH6 P52701 H367L 367 H L 0.73 Pathogenic MSH6 P52701 H367M 367 H M 0.638 Pathogenic MSH6 P52701 H367N 367 H N 0.202 Neutral MSH6 P52701 H367P 367 H P 0.912 Pathogenic MSH6 P52701 H367Q 367 H Q 0.364 Neutral MSH6 P52701 H367R 367 H R 0.4 Neutral MSH6 P52701 H367S 367 H S 0.422 Neutral MSH6 P52701 H367T 367 H T 0.468 Neutral MSH6 P52701 H367V 367 H V 0.554 Pathogenic MSH6 P52701 H367W 367 H W 0.956 Pathogenic MSH6 P52701 H367Y 367 H Y 0.782 Pathogenic MSH6 P52701 E368A 368 E A 0.176 Neutral MSH6 P52701 E368C 368 E C 0.108 Neutral MSH6 P52701 E368D 368 E D 0.002 Neutral MSH6 P52701 E368F 368 E F 0.474 Neutral MSH6 P52701 E368G 368 E G 0.11 Neutral MSH6 P52701 E368H 368 E H 0.05 Neutral MSH6 P52701 E368I 368 E I 0.45 Neutral MSH6 P52701 E368K 368 E K 0.274 Neutral MSH6 P52701 E368L 368 E L 0.06 Neutral MSH6 P52701 E368M 368 E M 0.29 Neutral MSH6 P52701 E368N 368 E N 0.002 Neutral MSH6 P52701 E368P 368 E P 0.462 Neutral MSH6 P52701 E368Q 368 E Q 0 Neutral MSH6 P52701 E368R 368 E R 0.118 Neutral MSH6 P52701 E368S 368 E S 0.216 Neutral MSH6 P52701 E368T 368 E T 0.248 Neutral MSH6 P52701 E368V 368 E V 0.374 Neutral MSH6 P52701 E368W 368 E W 0.694 Pathogenic MSH6 P52701 E368Y 368 E Y 0.652 Pathogenic MSH6 P52701 T369A 369 T A 0.108 Neutral MSH6 P52701 T369C 369 T C 0.122 Neutral MSH6 P52701 T369D 369 T D 0.028 Neutral MSH6 P52701 T369E 369 T E 0.154 Neutral MSH6 P52701 T369F 369 T F 0.428 Neutral MSH6 P52701 T369G 369 T G 0.066 Neutral MSH6 P52701 T369H 369 T H 0.09 Neutral MSH6 P52701 T369I 369 T I 0.186 Neutral MSH6 P52701 T369K 369 T K 0.024 Neutral MSH6 P52701 T369L 369 T L 0.182 Neutral MSH6 P52701 T369M 369 T M 0.28 Neutral MSH6 P52701 T369N 369 T N 0.004 Neutral MSH6 P52701 T369P 369 T P 0.236 Neutral MSH6 P52701 T369Q 369 T Q 0.108 Neutral MSH6 P52701 T369R 369 T R 0.238 Neutral MSH6 P52701 T369S 369 T S 0 Neutral MSH6 P52701 T369V 369 T V 0.344 Neutral MSH6 P52701 T369W 369 T W 0.71 Pathogenic MSH6 P52701 T369Y 369 T Y 0.67 Pathogenic MSH6 P52701 A37C 37 A C 0.182 Neutral MSH6 P52701 A37D 37 A D 0.316 Neutral MSH6 P52701 A37E 37 A E 0.306 Neutral MSH6 P52701 A37F 37 A F 0.468 Neutral MSH6 P52701 A37G 37 A G 0.006 Neutral MSH6 P52701 A37H 37 A H 0.304 Neutral MSH6 P52701 A37I 37 A I 0.406 Neutral MSH6 P52701 A37K 37 A K 0.32 Neutral MSH6 P52701 A37L 37 A L 0.4 Neutral MSH6 P52701 A37M 37 A M 0.29 Neutral MSH6 P52701 A37N 37 A N 0.274 Neutral MSH6 P52701 A37P 37 A P 0.138 Neutral MSH6 P52701 A37Q 37 A Q 0.302 Neutral MSH6 P52701 A37R 37 A R 0.318 Neutral MSH6 P52701 A37S 37 A S 0.068 Neutral MSH6 P52701 A37T 37 A T 0.172 Neutral MSH6 P52701 A37V 37 A V 0.136 Neutral MSH6 P52701 A37W 37 A W 0.504 Pathogenic MSH6 P52701 A37Y 37 A Y 0.5 Pathogenic MSH6 P52701 L370A 370 L A 0.258 Neutral MSH6 P52701 L370C 370 L C 0.296 Neutral MSH6 P52701 L370D 370 L D 0.57 Pathogenic MSH6 P52701 L370E 370 L E 0.47 Neutral MSH6 P52701 L370F 370 L F 0.294 Neutral MSH6 P52701 L370G 370 L G 0.524 Pathogenic MSH6 P52701 L370H 370 L H 0.3 Neutral MSH6 P52701 L370I 370 L I 0.33 Neutral MSH6 P52701 L370K 370 L K 0.426 Neutral MSH6 P52701 L370M 370 L M 0.428 Neutral MSH6 P52701 L370N 370 L N 0.546 Pathogenic MSH6 P52701 L370P 370 L P 0.856 Pathogenic MSH6 P52701 L370Q 370 L Q 0.222 Neutral MSH6 P52701 L370R 370 L R 0.816 Pathogenic MSH6 P52701 L370S 370 L S 0.396 Neutral MSH6 P52701 L370T 370 L T 0.468 Neutral MSH6 P52701 L370V 370 L V 0.406 Neutral MSH6 P52701 L370W 370 L W 0.714 Pathogenic MSH6 P52701 L370Y 370 L Y 0.61 Pathogenic MSH6 P52701 E371A 371 E A 0.174 Neutral MSH6 P52701 E371C 371 E C 0.362 Neutral MSH6 P52701 E371D 371 E D 0.03 Neutral MSH6 P52701 E371F 371 E F 0.748 Pathogenic MSH6 P52701 E371G 371 E G 0.314 Neutral MSH6 P52701 E371H 371 E H 0.146 Neutral MSH6 P52701 E371I 371 E I 0.804 Pathogenic MSH6 P52701 E371K 371 E K 0.038 Neutral MSH6 P52701 E371L 371 E L 0.794 Pathogenic MSH6 P52701 E371M 371 E M 0.612 Pathogenic MSH6 P52701 E371N 371 E N 0.228 Neutral MSH6 P52701 E371P 371 E P 0.104 Neutral MSH6 P52701 E371Q 371 E Q 0.206 Neutral MSH6 P52701 E371R 371 E R 0.082 Neutral MSH6 P52701 E371S 371 E S 0.058 Neutral MSH6 P52701 E371T 371 E T 0.066 Neutral MSH6 P52701 E371V 371 E V 0.756 Pathogenic MSH6 P52701 E371W 371 E W 0.914 Pathogenic MSH6 P52701 E371Y 371 E Y 0.816 Pathogenic MSH6 P52701 W372A 372 W A 0.38 Neutral MSH6 P52701 W372C 372 W C 0.384 Neutral MSH6 P52701 W372D 372 W D 0.506 Pathogenic MSH6 P52701 W372E 372 W E 0.794 Pathogenic MSH6 P52701 W372F 372 W F 0.064 Neutral MSH6 P52701 W372G 372 W G 0.402 Neutral MSH6 P52701 W372H 372 W H 0.592 Pathogenic MSH6 P52701 W372I 372 W I 0.458 Neutral MSH6 P52701 W372K 372 W K 0.878 Pathogenic MSH6 P52701 W372L 372 W L 0.392 Neutral MSH6 P52701 W372M 372 W M 0.586 Pathogenic MSH6 P52701 W372N 372 W N 0.414 Neutral MSH6 P52701 W372P 372 W P 0.524 Pathogenic MSH6 P52701 W372Q 372 W Q 0.51 Pathogenic MSH6 P52701 W372R 372 W R 0.712 Pathogenic MSH6 P52701 W372S 372 W S 0.39 Neutral MSH6 P52701 W372T 372 W T 0.38 Neutral MSH6 P52701 W372V 372 W V 0.456 Neutral MSH6 P52701 W372Y 372 W Y 0.862 Pathogenic MSH6 P52701 L373A 373 L A 0.62 Pathogenic MSH6 P52701 L373C 373 L C 0.324 Neutral MSH6 P52701 L373D 373 L D 0.86 Pathogenic MSH6 P52701 L373E 373 L E 0.85 Pathogenic MSH6 P52701 L373F 373 L F 0.66 Pathogenic MSH6 P52701 L373G 373 L G 0.776 Pathogenic MSH6 P52701 L373H 373 L H 0.866 Pathogenic MSH6 P52701 L373I 373 L I 0.266 Neutral MSH6 P52701 L373K 373 L K 0.724 Pathogenic MSH6 P52701 L373M 373 L M 0.214 Neutral MSH6 P52701 L373N 373 L N 0.728 Pathogenic MSH6 P52701 L373P 373 L P 0.97 Pathogenic MSH6 P52701 L373Q 373 L Q 0.668 Pathogenic MSH6 P52701 L373R 373 L R 0.978 Pathogenic MSH6 P52701 L373S 373 L S 0.588 Pathogenic MSH6 P52701 L373T 373 L T 0.552 Pathogenic MSH6 P52701 L373V 373 L V 0.284 Neutral MSH6 P52701 L373W 373 L W 0.93 Pathogenic MSH6 P52701 L373Y 373 L Y 0.892 Pathogenic MSH6 P52701 K374A 374 K A 0.078 Neutral MSH6 P52701 K374C 374 K C 0.188 Neutral MSH6 P52701 K374D 374 K D 0.246 Neutral MSH6 P52701 K374E 374 K E 0.036 Neutral MSH6 P52701 K374F 374 K F 0.66 Pathogenic MSH6 P52701 K374G 374 K G 0.098 Neutral MSH6 P52701 K374H 374 K H 0.026 Neutral MSH6 P52701 K374I 374 K I 0.698 Pathogenic MSH6 P52701 K374L 374 K L 0.088 Neutral MSH6 P52701 K374M 374 K M 0.498 Neutral MSH6 P52701 K374N 374 K N 0.282 Neutral MSH6 P52701 K374P 374 K P 0.708 Pathogenic MSH6 P52701 K374Q 374 K Q 0.046 Neutral MSH6 P52701 K374R 374 K R 0.036 Neutral MSH6 P52701 K374S 374 K S 0.492 Neutral MSH6 P52701 K374T 374 K T 0.12 Neutral MSH6 P52701 K374V 374 K V 0.416 Neutral MSH6 P52701 K374W 374 K W 0.872 Pathogenic MSH6 P52701 K374Y 374 K Y 0.826 Pathogenic MSH6 P52701 E375A 375 E A 0.112 Neutral MSH6 P52701 E375C 375 E C 0.138 Neutral MSH6 P52701 E375D 375 E D 0.004 Neutral MSH6 P52701 E375F 375 E F 0.45 Neutral MSH6 P52701 E375G 375 E G 0.008 Neutral MSH6 P52701 E375H 375 E H 0.064 Neutral MSH6 P52701 E375I 375 E I 0.488 Neutral MSH6 P52701 E375K 375 E K 0.008 Neutral MSH6 P52701 E375L 375 E L 0.486 Neutral MSH6 P52701 E375M 375 E M 0.316 Neutral MSH6 P52701 E375N 375 E N 0.088 Neutral MSH6 P52701 E375P 375 E P 0.082 Neutral MSH6 P52701 E375Q 375 E Q 0.012 Neutral MSH6 P52701 E375R 375 E R 0.134 Neutral MSH6 P52701 E375S 375 E S 0.116 Neutral MSH6 P52701 E375T 375 E T 0.046 Neutral MSH6 P52701 E375V 375 E V 0.066 Neutral MSH6 P52701 E375W 375 E W 0.764 Pathogenic MSH6 P52701 E375Y 375 E Y 0.624 Pathogenic MSH6 P52701 E376A 376 E A 0.112 Neutral MSH6 P52701 E376C 376 E C 0.134 Neutral MSH6 P52701 E376D 376 E D 0.004 Neutral MSH6 P52701 E376F 376 E F 0.45 Neutral MSH6 P52701 E376G 376 E G 0.002 Neutral MSH6 P52701 E376H 376 E H 0.198 Neutral MSH6 P52701 E376I 376 E I 0.546 Pathogenic MSH6 P52701 E376K 376 E K 0.016 Neutral MSH6 P52701 E376L 376 E L 0.486 Neutral MSH6 P52701 E376M 376 E M 0.316 Neutral MSH6 P52701 E376N 376 E N 0.006 Neutral MSH6 P52701 E376P 376 E P 0.078 Neutral MSH6 P52701 E376Q 376 E Q 0.098 Neutral MSH6 P52701 E376R 376 E R 0.13 Neutral MSH6 P52701 E376S 376 E S 0.116 Neutral MSH6 P52701 E376T 376 E T 0.24 Neutral MSH6 P52701 E376V 376 E V 0.436 Neutral MSH6 P52701 E376W 376 E W 0.764 Pathogenic MSH6 P52701 E376Y 376 E Y 0.624 Pathogenic MSH6 P52701 K377A 377 K A 0.226 Neutral MSH6 P52701 K377C 377 K C 0.192 Neutral MSH6 P52701 K377D 377 K D 0.016 Neutral MSH6 P52701 K377E 377 K E 0.23 Neutral MSH6 P52701 K377F 377 K F 0.764 Pathogenic MSH6 P52701 K377G 377 K G 0.086 Neutral MSH6 P52701 K377H 377 K H 0.008 Neutral MSH6 P52701 K377I 377 K I 0.8 Pathogenic MSH6 P52701 K377L 377 K L 0.76 Pathogenic MSH6 P52701 K377M 377 K M 0.56 Pathogenic MSH6 P52701 K377N 377 K N 0.02 Neutral MSH6 P52701 K377P 377 K P 0.78 Pathogenic MSH6 P52701 K377Q 377 K Q 0.03 Neutral MSH6 P52701 K377R 377 K R 0.014 Neutral MSH6 P52701 K377S 377 K S 0.576 Pathogenic MSH6 P52701 K377T 377 K T 0.504 Pathogenic MSH6 P52701 K377V 377 K V 0.446 Neutral MSH6 P52701 K377W 377 K W 0.932 Pathogenic MSH6 P52701 K377Y 377 K Y 0.37 Neutral MSH6 P52701 R378A 378 R A 0.43 Neutral MSH6 P52701 R378C 378 R C 0.662 Pathogenic MSH6 P52701 R378D 378 R D 0.628 Pathogenic MSH6 P52701 R378E 378 R E 0.55 Pathogenic MSH6 P52701 R378F 378 R F 0.938 Pathogenic MSH6 P52701 R378G 378 R G 0.21 Neutral MSH6 P52701 R378H 378 R H 0.48 Neutral MSH6 P52701 R378I 378 R I 0.214 Neutral MSH6 P52701 R378K 378 R K 0.048 Neutral MSH6 P52701 R378L 378 R L 0.13 Neutral MSH6 P52701 R378M 378 R M 0.076 Neutral MSH6 P52701 R378N 378 R N 0.494 Neutral MSH6 P52701 R378P 378 R P 0.85 Pathogenic MSH6 P52701 R378Q 378 R Q 0.05 Neutral MSH6 P52701 R378S 378 R S 0.452 Neutral MSH6 P52701 R378T 378 R T 0.546 Pathogenic MSH6 P52701 R378V 378 R V 0.124 Neutral MSH6 P52701 R378W 378 R W 0.916 Pathogenic MSH6 P52701 R378Y 378 R Y 0.896 Pathogenic MSH6 P52701 R379A 379 R A 0.43 Neutral MSH6 P52701 R379C 379 R C 0.262 Neutral MSH6 P52701 R379D 379 R D 0.626 Pathogenic MSH6 P52701 R379E 379 R E 0.426 Neutral MSH6 P52701 R379F 379 R F 0.938 Pathogenic MSH6 P52701 R379G 379 R G 0.21 Neutral MSH6 P52701 R379H 379 R H 0.48 Neutral MSH6 P52701 R379I 379 R I 0.768 Pathogenic MSH6 P52701 R379K 379 R K 0.056 Neutral MSH6 P52701 R379L 379 R L 0.216 Neutral MSH6 P52701 R379M 379 R M 0.056 Neutral MSH6 P52701 R379N 379 R N 0.492 Neutral MSH6 P52701 R379P 379 R P 0.848 Pathogenic MSH6 P52701 R379Q 379 R Q 0.018 Neutral MSH6 P52701 R379S 379 R S 0.452 Neutral MSH6 P52701 R379T 379 R T 0.086 Neutral MSH6 P52701 R379V 379 R V 0.634 Pathogenic MSH6 P52701 R379W 379 R W 0.914 Pathogenic MSH6 P52701 R379Y 379 R Y 0.894 Pathogenic MSH6 P52701 P38A 38 P A 0.176 Neutral MSH6 P52701 P38C 38 P C 0.148 Neutral MSH6 P52701 P38D 38 P D 0.05 Neutral MSH6 P52701 P38E 38 P E 0.166 Neutral MSH6 P52701 P38F 38 P F 0.272 Neutral MSH6 P52701 P38G 38 P G 0.01 Neutral MSH6 P52701 P38H 38 P H 0.266 Neutral MSH6 P52701 P38I 38 P I 0.104 Neutral MSH6 P52701 P38K 38 P K 0.206 Neutral MSH6 P52701 P38L 38 P L 0.094 Neutral MSH6 P52701 P38M 38 P M 0.22 Neutral MSH6 P52701 P38N 38 P N 0.068 Neutral MSH6 P52701 P38Q 38 P Q 0.212 Neutral MSH6 P52701 P38R 38 P R 0.202 Neutral MSH6 P52701 P38S 38 P S 0.002 Neutral MSH6 P52701 P38T 38 P T 0.014 Neutral MSH6 P52701 P38V 38 P V 0.14 Neutral MSH6 P52701 P38W 38 P W 0.39 Neutral MSH6 P52701 P38Y 38 P Y 0.32 Neutral MSH6 P52701 D380A 380 D A 0.78 Pathogenic MSH6 P52701 D380C 380 D C 0.862 Pathogenic MSH6 P52701 D380E 380 D E 0.766 Pathogenic MSH6 P52701 D380F 380 D F 0.974 Pathogenic MSH6 P52701 D380G 380 D G 0.298 Neutral MSH6 P52701 D380H 380 D H 0.596 Pathogenic MSH6 P52701 D380I 380 D I 0.964 Pathogenic MSH6 P52701 D380K 380 D K 0.888 Pathogenic MSH6 P52701 D380L 380 D L 0.966 Pathogenic MSH6 P52701 D380M 380 D M 0.944 Pathogenic MSH6 P52701 D380N 380 D N 0.844 Pathogenic MSH6 P52701 D380P 380 D P 0.884 Pathogenic MSH6 P52701 D380Q 380 D Q 0.574 Pathogenic MSH6 P52701 D380R 380 D R 0.954 Pathogenic MSH6 P52701 D380S 380 D S 0.542 Pathogenic MSH6 P52701 D380T 380 D T 0.772 Pathogenic MSH6 P52701 D380V 380 D V 0.984 Pathogenic MSH6 P52701 D380W 380 D W 0.976 Pathogenic MSH6 P52701 D380Y 380 D Y 0.968 Pathogenic MSH6 P52701 E381A 381 E A 0.202 Neutral MSH6 P52701 E381C 381 E C 0.424 Neutral MSH6 P52701 E381D 381 E D 0.408 Neutral MSH6 P52701 E381F 381 E F 0.798 Pathogenic MSH6 P52701 E381G 381 E G 0.014 Neutral MSH6 P52701 E381H 381 E H 0.556 Pathogenic MSH6 P52701 E381I 381 E I 0.188 Neutral MSH6 P52701 E381K 381 E K 0.036 Neutral MSH6 P52701 E381L 381 E L 0.114 Neutral MSH6 P52701 E381M 381 E M 0.052 Neutral MSH6 P52701 E381N 381 E N 0.164 Neutral MSH6 P52701 E381P 381 E P 0.858 Pathogenic MSH6 P52701 E381Q 381 E Q 0.166 Neutral MSH6 P52701 E381R 381 E R 0.392 Neutral MSH6 P52701 E381S 381 E S 0.036 Neutral MSH6 P52701 E381T 381 E T 0.6 Pathogenic MSH6 P52701 E381V 381 E V 0.096 Neutral MSH6 P52701 E381W 381 E W 0.934 Pathogenic MSH6 P52701 E381Y 381 E Y 0.86 Pathogenic MSH6 P52701 H382A 382 H A 0.108 Neutral MSH6 P52701 H382C 382 H C 0.036 Neutral MSH6 P52701 H382D 382 H D 0.042 Neutral MSH6 P52701 H382E 382 H E 0.026 Neutral MSH6 P52701 H382F 382 H F 0.7 Pathogenic MSH6 P52701 H382G 382 H G 0.276 Neutral MSH6 P52701 H382I 382 H I 0.672 Pathogenic MSH6 P52701 H382K 382 H K 0.036 Neutral MSH6 P52701 H382L 382 H L 0.642 Pathogenic MSH6 P52701 H382M 382 H M 0.554 Pathogenic MSH6 P52701 H382N 382 H N 0.036 Neutral MSH6 P52701 H382P 382 H P 0.786 Pathogenic MSH6 P52701 H382Q 382 H Q 0.036 Neutral MSH6 P52701 H382R 382 H R 0.026 Neutral MSH6 P52701 H382S 382 H S 0.068 Neutral MSH6 P52701 H382T 382 H T 0.516 Pathogenic MSH6 P52701 H382V 382 H V 0.49 Neutral MSH6 P52701 H382W 382 H W 0.846 Pathogenic MSH6 P52701 H382Y 382 H Y 0.078 Neutral MSH6 P52701 R383A 383 R A 0.268 Neutral MSH6 P52701 R383C 383 R C 0.806 Pathogenic MSH6 P52701 R383D 383 R D 0.738 Pathogenic MSH6 P52701 R383E 383 R E 0.676 Pathogenic MSH6 P52701 R383F 383 R F 0.936 Pathogenic MSH6 P52701 R383G 383 R G 0.098 Neutral MSH6 P52701 R383H 383 R H 0.462 Neutral MSH6 P52701 R383I 383 R I 0.938 Pathogenic MSH6 P52701 R383K 383 R K 0.336 Neutral MSH6 P52701 R383L 383 R L 0.92 Pathogenic MSH6 P52701 R383M 383 R M 0.71 Pathogenic MSH6 P52701 R383N 383 R N 0.656 Pathogenic MSH6 P52701 R383P 383 R P 0.918 Pathogenic MSH6 P52701 R383Q 383 R Q 0.178 Neutral MSH6 P52701 R383S 383 R S 0.714 Pathogenic MSH6 P52701 R383T 383 R T 0.752 Pathogenic MSH6 P52701 R383V 383 R V 0.908 Pathogenic MSH6 P52701 R383W 383 R W 0.93 Pathogenic MSH6 P52701 R383Y 383 R Y 0.92 Pathogenic MSH6 P52701 R384A 384 R A 0.49 Neutral MSH6 P52701 R384C 384 R C 0.79 Pathogenic MSH6 P52701 R384D 384 R D 0.722 Pathogenic MSH6 P52701 R384E 384 R E 0.66 Pathogenic MSH6 P52701 R384F 384 R F 0.926 Pathogenic MSH6 P52701 R384G 384 R G 0.33 Neutral MSH6 P52701 R384H 384 R H 0.138 Neutral MSH6 P52701 R384I 384 R I 0.712 Pathogenic MSH6 P52701 R384K 384 R K 0.326 Neutral MSH6 P52701 R384L 384 R L 0.912 Pathogenic MSH6 P52701 R384M 384 R M 0.696 Pathogenic MSH6 P52701 R384N 384 R N 0.14 Neutral MSH6 P52701 R384P 384 R P 0.908 Pathogenic MSH6 P52701 R384Q 384 R Q 0.534 Pathogenic MSH6 P52701 R384S 384 R S 0.314 Neutral MSH6 P52701 R384T 384 R T 0.734 Pathogenic MSH6 P52701 R384V 384 R V 0.63 Pathogenic MSH6 P52701 R384W 384 R W 0.918 Pathogenic MSH6 P52701 R384Y 384 R Y 0.906 Pathogenic MSH6 P52701 R385A 385 R A 0.13 Neutral MSH6 P52701 R385C 385 R C 0.086 Neutral MSH6 P52701 R385D 385 R D 0.63 Pathogenic MSH6 P52701 R385E 385 R E 0.504 Pathogenic MSH6 P52701 R385F 385 R F 0.81 Pathogenic MSH6 P52701 R385G 385 R G 0.204 Neutral MSH6 P52701 R385H 385 R H 0.496 Neutral MSH6 P52701 R385I 385 R I 0.882 Pathogenic MSH6 P52701 R385K 385 R K 0.042 Neutral MSH6 P52701 R385L 385 R L 0.116 Neutral MSH6 P52701 R385M 385 R M 0.158 Neutral MSH6 P52701 R385N 385 R N 0.508 Pathogenic MSH6 P52701 R385P 385 R P 0.138 Neutral MSH6 P52701 R385Q 385 R Q 0.45 Neutral MSH6 P52701 R385S 385 R S 0.054 Neutral MSH6 P52701 R385T 385 R T 0.07 Neutral MSH6 P52701 R385V 385 R V 0.794 Pathogenic MSH6 P52701 R385W 385 R W 0.888 Pathogenic MSH6 P52701 R385Y 385 R Y 0.846 Pathogenic MSH6 P52701 P386A 386 P A 0.07 Neutral MSH6 P52701 P386C 386 P C 0.586 Pathogenic MSH6 P52701 P386D 386 P D 0.272 Neutral MSH6 P52701 P386E 386 P E 0.148 Neutral MSH6 P52701 P386F 386 P F 0.756 Pathogenic MSH6 P52701 P386G 386 P G 0.266 Neutral MSH6 P52701 P386H 386 P H 0.558 Pathogenic MSH6 P52701 P386I 386 P I 0.134 Neutral MSH6 P52701 P386K 386 P K 0.128 Neutral MSH6 P52701 P386L 386 P L 0.12 Neutral MSH6 P52701 P386M 386 P M 0.22 Neutral MSH6 P52701 P386N 386 P N 0.308 Neutral MSH6 P52701 P386Q 386 P Q 0.134 Neutral MSH6 P52701 P386R 386 P R 0.536 Pathogenic MSH6 P52701 P386S 386 P S 0.214 Neutral MSH6 P52701 P386T 386 P T 0.458 Neutral MSH6 P52701 P386V 386 P V 0.142 Neutral MSH6 P52701 P386W 386 P W 0.924 Pathogenic MSH6 P52701 P386Y 386 P Y 0.908 Pathogenic MSH6 P52701 D387A 387 D A 0.134 Neutral MSH6 P52701 D387C 387 D C 0.73 Pathogenic MSH6 P52701 D387E 387 D E 0.054 Neutral MSH6 P52701 D387F 387 D F 0.928 Pathogenic MSH6 P52701 D387G 387 D G 0.068 Neutral MSH6 P52701 D387H 387 D H 0.444 Neutral MSH6 P52701 D387I 387 D I 0.838 Pathogenic MSH6 P52701 D387K 387 D K 0.384 Neutral MSH6 P52701 D387L 387 D L 0.884 Pathogenic MSH6 P52701 D387M 387 D M 0.798 Pathogenic MSH6 P52701 D387N 387 D N 0.01 Neutral MSH6 P52701 D387P 387 D P 0.804 Pathogenic MSH6 P52701 D387Q 387 D Q 0.178 Neutral MSH6 P52701 D387R 387 D R 0.742 Pathogenic MSH6 P52701 D387S 387 D S 0.01 Neutral MSH6 P52701 D387T 387 D T 0.052 Neutral MSH6 P52701 D387V 387 D V 0.912 Pathogenic MSH6 P52701 D387W 387 D W 0.97 Pathogenic MSH6 P52701 D387Y 387 D Y 0.964 Pathogenic MSH6 P52701 H388A 388 H A 0.566 Pathogenic MSH6 P52701 H388C 388 H C 0.112 Neutral MSH6 P52701 H388D 388 H D 0.152 Neutral MSH6 P52701 H388E 388 H E 0.068 Neutral MSH6 P52701 H388F 388 H F 0.812 Pathogenic MSH6 P52701 H388G 388 H G 0.492 Neutral MSH6 P52701 H388I 388 H I 0.848 Pathogenic MSH6 P52701 H388K 388 H K 0.678 Pathogenic MSH6 P52701 H388L 388 H L 0.764 Pathogenic MSH6 P52701 H388M 388 H M 0.694 Pathogenic MSH6 P52701 H388N 388 H N 0.074 Neutral MSH6 P52701 H388P 388 H P 0.948 Pathogenic MSH6 P52701 H388Q 388 H Q 0.686 Pathogenic MSH6 P52701 H388R 388 H R 0.74 Pathogenic MSH6 P52701 H388S 388 H S 0.134 Neutral MSH6 P52701 H388T 388 H T 0.626 Pathogenic MSH6 P52701 H388V 388 H V 0.594 Pathogenic MSH6 P52701 H388W 388 H W 0.768 Pathogenic MSH6 P52701 H388Y 388 H Y 0.822 Pathogenic MSH6 P52701 P389A 389 P A 0.166 Neutral MSH6 P52701 P389C 389 P C 0.52 Pathogenic MSH6 P52701 P389D 389 P D 0.228 Neutral MSH6 P52701 P389E 389 P E 0.258 Neutral MSH6 P52701 P389F 389 P F 0.99 Pathogenic MSH6 P52701 P389G 389 P G 0.576 Pathogenic MSH6 P52701 P389H 389 P H 0.972 Pathogenic MSH6 P52701 P389I 389 P I 0.914 Pathogenic MSH6 P52701 P389K 389 P K 0.584 Pathogenic MSH6 P52701 P389L 389 P L 0.692 Pathogenic MSH6 P52701 P389M 389 P M 0.948 Pathogenic MSH6 P52701 P389N 389 P N 0.694 Pathogenic MSH6 P52701 P389Q 389 P Q 0.838 Pathogenic MSH6 P52701 P389R 389 P R 0.974 Pathogenic MSH6 P52701 P389S 389 P S 0.108 Neutral MSH6 P52701 P389T 389 P T 0.668 Pathogenic MSH6 P52701 P389V 389 P V 0.18 Neutral MSH6 P52701 P389W 389 P W 0.932 Pathogenic MSH6 P52701 P389Y 389 P Y 0.93 Pathogenic MSH6 P52701 G39A 39 G A 0.002 Neutral MSH6 P52701 G39C 39 G C 0.14 Neutral MSH6 P52701 G39D 39 G D 0.154 Neutral MSH6 P52701 G39E 39 G E 0.166 Neutral 1 MSH6 P52701 G39F 39 G F 0.498 Neutral MSH6 P52701 G39H 39 G H 0.442 Neutral MSH6 P52701 G39I 39 G I 0.412 Neutral MSH6 P52701 G39K 39 G K 0.416 Neutral MSH6 P52701 G39L 39 G L 0.412 Neutral MSH6 P52701 G39M 39 G M 0.422 Neutral MSH6 P52701 G39N 39 G N 0.252 Neutral MSH6 P52701 G39P 39 G P 0.442 Neutral MSH6 P52701 G39Q 39 G Q 0.262 Neutral MSH6 P52701 G39R 39 G R 0.324 Neutral MSH6 P52701 G39S 39 G S 0.022 Neutral MSH6 P52701 G39T 39 G T 0.274 Neutral MSH6 P52701 G39V 39 G V 0.39 Neutral MSH6 P52701 G39W 39 G W 0.458 Neutral MSH6 P52701 G39Y 39 G Y 0.5 Pathogenic MSH6 P52701 D390A 390 D A 0.208 Neutral MSH6 P52701 D390C 390 D C 0.876 Pathogenic MSH6 P52701 D390E 390 D E 0.214 Neutral MSH6 P52701 D390F 390 D F 0.976 Pathogenic MSH6 P52701 D390G 390 D G 0.168 Neutral MSH6 P52701 D390H 390 D H 0.426 Neutral MSH6 P52701 D390I 390 D I 0.966 Pathogenic MSH6 P52701 D390K 390 D K 0.37 Neutral MSH6 P52701 D390L 390 D L 0.476 Neutral MSH6 P52701 D390M 390 D M 0.922 Pathogenic MSH6 P52701 D390N 390 D N 0.076 Neutral MSH6 P52701 D390P 390 D P 0.886 Pathogenic MSH6 P52701 D390Q 390 D Q 0.744 Pathogenic MSH6 P52701 D390R 390 D R 0.888 Pathogenic MSH6 P52701 D390S 390 D S 0.172 Neutral MSH6 P52701 D390T 390 D T 0.794 Pathogenic MSH6 P52701 D390V 390 D V 0.982 Pathogenic MSH6 P52701 D390W 390 D W 0.982 Pathogenic MSH6 P52701 D390Y 390 D Y 0.926 Pathogenic MSH6 P52701 F391A 391 F A 0.494 Neutral MSH6 P52701 F391C 391 F C 0.718 Pathogenic MSH6 P52701 F391D 391 F D 0.8 Pathogenic MSH6 P52701 F391E 391 F E 0.844 Pathogenic MSH6 P52701 F391G 391 F G 0.506 Pathogenic MSH6 P52701 F391H 391 F H 0.38 Neutral MSH6 P52701 F391I 391 F I 0.662 Pathogenic MSH6 P52701 F391K 391 F K 0.82 Pathogenic MSH6 P52701 F391L 391 F L 0.682 Pathogenic MSH6 P52701 F391M 391 F M 0.768 Pathogenic MSH6 P52701 F391N 391 F N 0.748 Pathogenic MSH6 P52701 F391P 391 F P 0.944 Pathogenic MSH6 P52701 F391Q 391 F Q 0.76 Pathogenic MSH6 P52701 F391R 391 F R 0.892 Pathogenic MSH6 P52701 F391S 391 F S 0.872 Pathogenic MSH6 P52701 F391T 391 F T 0.574 Pathogenic MSH6 P52701 F391V 391 F V 0.706 Pathogenic MSH6 P52701 F391W 391 F W 0.83 Pathogenic MSH6 P52701 F391Y 391 F Y 0.322 Neutral MSH6 P52701 D392A 392 D A 0.786 Pathogenic MSH6 P52701 D392C 392 D C 0.448 Neutral MSH6 P52701 D392E 392 D E 0.784 Pathogenic MSH6 P52701 D392F 392 D F 0.978 Pathogenic MSH6 P52701 D392G 392 D G 0.936 Pathogenic MSH6 P52701 D392H 392 D H 0.606 Pathogenic MSH6 P52701 D392I 392 D I 0.97 Pathogenic MSH6 P52701 D392K 392 D K 0.902 Pathogenic MSH6 P52701 D392L 392 D L 0.974 Pathogenic MSH6 P52701 D392M 392 D M 0.95 Pathogenic MSH6 P52701 D392N 392 D N 0.36 Neutral MSH6 P52701 D392P 392 D P 0.892 Pathogenic MSH6 P52701 D392Q 392 D Q 0.588 Pathogenic MSH6 P52701 D392R 392 D R 0.958 Pathogenic MSH6 P52701 D392S 392 D S 0.296 Neutral MSH6 P52701 D392T 392 D T 0.784 Pathogenic MSH6 P52701 D392V 392 D V 0.99 Pathogenic MSH6 P52701 D392W 392 D W 0.982 Pathogenic MSH6 P52701 D392Y 392 D Y 0.974 Pathogenic MSH6 P52701 A393C 393 A C 0.696 Pathogenic MSH6 P52701 A393D 393 A D 0.806 Pathogenic MSH6 P52701 A393E 393 A E 0.752 Pathogenic MSH6 P52701 A393F 393 A F 0.998 Pathogenic MSH6 P52701 A393G 393 A G 0.126 Neutral MSH6 P52701 A393H 393 A H 0.942 Pathogenic MSH6 P52701 A393I 393 A I 0.96 Pathogenic MSH6 P52701 A393K 393 A K 0.638 Pathogenic MSH6 P52701 A393L 393 A L 1 Pathogenic MSH6 P52701 A393M 393 A M 0.908 Pathogenic MSH6 P52701 A393N 393 A N 0.65 Pathogenic MSH6 P52701 A393P 393 A P 0.482 Neutral MSH6 P52701 A393Q 393 A Q 0.652 Pathogenic MSH6 P52701 A393R 393 A R 0.71 Pathogenic MSH6 P52701 A393S 393 A S 0.12 Neutral MSH6 P52701 A393T 393 A T 0.442 Neutral MSH6 P52701 A393V 393 A V 0.926 Pathogenic MSH6 P52701 A393W 393 A W 0.996 Pathogenic MSH6 P52701 A393Y 393 A Y 0.966 Pathogenic MSH6 P52701 S394A 394 S A 0.072 Neutral MSH6 P52701 S394C 394 S C 0.08 Neutral MSH6 P52701 S394D 394 S D 0.578 Pathogenic MSH6 P52701 S394E 394 S E 0.764 Pathogenic MSH6 P52701 S394F 394 S F 0.886 Pathogenic MSH6 P52701 S394G 394 S G 0.038 Neutral MSH6 P52701 S394H 394 S H 0.66 Pathogenic MSH6 P52701 S394I 394 S I 0.644 Pathogenic MSH6 P52701 S394K 394 S K 0.47 Neutral MSH6 P52701 S394L 394 S L 0.664 Pathogenic MSH6 P52701 S394M 394 S M 0.944 Pathogenic MSH6 P52701 S394N 394 S N 0.206 Neutral MSH6 P52701 S394P 394 S P 0.688 Pathogenic MSH6 P52701 S394Q 394 S Q 0.722 Pathogenic MSH6 P52701 S394R 394 S R 0.508 Pathogenic MSH6 P52701 S394T 394 S T 0.07 Neutral MSH6 P52701 S394V 394 S V 0.76 Pathogenic MSH6 P52701 S394W 394 S W 0.91 Pathogenic MSH6 P52701 S394Y 394 S Y 0.896 Pathogenic MSH6 P52701 T395A 395 T A 0.708 Pathogenic MSH6 P52701 T395C 395 T C 0.938 Pathogenic MSH6 P52701 T395D 395 T D 0.954 Pathogenic MSH6 P52701 T395E 395 T E 0.952 Pathogenic MSH6 P52701 T395F 395 T F 0.95 Pathogenic MSH6 P52701 T395G 395 T G 0.746 Pathogenic MSH6 P52701 T395H 395 T H 0.922 Pathogenic MSH6 P52701 T395I 395 T I 0.952 Pathogenic MSH6 P52701 T395K 395 T K 0.94 Pathogenic MSH6 P52701 T395L 395 T L 0.952 Pathogenic MSH6 P52701 T395M 395 T M 0.982 Pathogenic MSH6 P52701 T395N 395 T N 0.55 Pathogenic MSH6 P52701 T395P 395 T P 0.968 Pathogenic MSH6 P52701 T395Q 395 T Q 0.894 Pathogenic MSH6 P52701 T395R 395 T R 0.994 Pathogenic MSH6 P52701 T395S 395 T S 0.358 Neutral MSH6 P52701 T395V 395 T V 0.832 Pathogenic MSH6 P52701 T395W 395 T W 0.974 Pathogenic MSH6 P52701 T395Y 395 T Y 0.974 Pathogenic MSH6 P52701 L396A 396 L A 0.706 Pathogenic MSH6 P52701 L396C 396 L C 0.812 Pathogenic MSH6 P52701 L396D 396 L D 0.884 Pathogenic MSH6 P52701 L396E 396 L E 0.864 Pathogenic MSH6 P52701 L396F 396 L F 0.856 Pathogenic MSH6 P52701 L396G 396 L G 0.848 Pathogenic MSH6 P52701 L396H 396 L H 0.908 Pathogenic MSH6 P52701 L396I 396 L I 0.224 Neutral MSH6 P52701 L396K 396 L K 0.708 Pathogenic MSH6 P52701 L396M 396 L M 0.606 Pathogenic MSH6 P52701 L396N 396 L N 0.78 Pathogenic MSH6 P52701 L396P 396 L P 0.984 Pathogenic MSH6 P52701 L396Q 396 L Q 0.744 Pathogenic MSH6 P52701 L396R 396 L R 0.978 Pathogenic MSH6 P52701 L396S 396 L S 0.668 Pathogenic MSH6 P52701 L396T 396 L T 0.6 Pathogenic MSH6 P52701 L396V 396 L V 0.042 Neutral 1 MSH6 P52701 L396W 396 L W 0.856 Pathogenic MSH6 P52701 L396Y 396 L Y 0.87 Pathogenic MSH6 P52701 Y397A 397 Y A 0.338 Neutral MSH6 P52701 Y397C 397 Y C 0.546 Pathogenic MSH6 P52701 Y397D 397 Y D 0.796 Pathogenic MSH6 P52701 Y397E 397 Y E 0.728 Pathogenic MSH6 P52701 Y397F 397 Y F 0.06 Neutral MSH6 P52701 Y397G 397 Y G 0.384 Neutral MSH6 P52701 Y397H 397 Y H 0.088 Neutral MSH6 P52701 Y397I 397 Y I 0.672 Pathogenic MSH6 P52701 Y397K 397 Y K 0.144 Neutral MSH6 P52701 Y397L 397 Y L 0.128 Neutral MSH6 P52701 Y397M 397 Y M 0.604 Pathogenic MSH6 P52701 Y397N 397 Y N 0.626 Pathogenic MSH6 P52701 Y397P 397 Y P 0.692 Pathogenic MSH6 P52701 Y397Q 397 Y Q 0.206 Neutral MSH6 P52701 Y397R 397 Y R 0.458 Neutral MSH6 P52701 Y397S 397 Y S 0.168 Neutral MSH6 P52701 Y397T 397 Y T 0.54 Pathogenic MSH6 P52701 Y397V 397 Y V 0.712 Pathogenic MSH6 P52701 Y397W 397 Y W 0.212 Neutral MSH6 P52701 V398A 398 V A 0.32 Neutral MSH6 P52701 V398C 398 V C 0.72 Pathogenic MSH6 P52701 V398D 398 V D 0.86 Pathogenic MSH6 P52701 V398E 398 V E 0.976 Pathogenic 5 MSH6 P52701 V398F 398 V F 0.892 Pathogenic MSH6 P52701 V398G 398 V G 0.882 Pathogenic MSH6 P52701 V398H 398 V H 0.832 Pathogenic MSH6 P52701 V398I 398 V I 0.184 Neutral MSH6 P52701 V398K 398 V K 0.986 Pathogenic MSH6 P52701 V398L 398 V L 0.246 Neutral MSH6 P52701 V398M 398 V M 0.832 Pathogenic MSH6 P52701 V398N 398 V N 0.918 Pathogenic MSH6 P52701 V398P 398 V P 0.976 Pathogenic MSH6 P52701 V398Q 398 V Q 0.982 Pathogenic MSH6 P52701 V398R 398 V R 0.954 Pathogenic MSH6 P52701 V398S 398 V S 0.722 Pathogenic MSH6 P52701 V398T 398 V T 0.77 Pathogenic MSH6 P52701 V398W 398 V W 0.92 Pathogenic MSH6 P52701 V398Y 398 V Y 0.948 Pathogenic MSH6 P52701 P399A 399 P A 0.834 Pathogenic MSH6 P52701 P399C 399 P C 0.918 Pathogenic MSH6 P52701 P399D 399 P D 0.504 Pathogenic MSH6 P52701 P399E 399 P E 0.96 Pathogenic MSH6 P52701 P399F 399 P F 1 Pathogenic MSH6 P52701 P399G 399 P G 0.694 Pathogenic MSH6 P52701 P399H 399 P H 0.978 Pathogenic MSH6 P52701 P399I 399 P I 0.938 Pathogenic MSH6 P52701 P399K 399 P K 0.95 Pathogenic MSH6 P52701 P399L 399 P L 0.998 Pathogenic MSH6 P52701 P399M 399 P M 0.96 Pathogenic MSH6 P52701 P399N 399 P N 0.574 Pathogenic MSH6 P52701 P399Q 399 P Q 0.882 Pathogenic MSH6 P52701 P399R 399 P R 0.986 Pathogenic MSH6 P52701 P399S 399 P S 0.298 Neutral MSH6 P52701 P399T 399 P T 0.738 Pathogenic MSH6 P52701 P399V 399 P V 0.844 Pathogenic MSH6 P52701 P399W 399 P W 0.932 Pathogenic MSH6 P52701 P399Y 399 P Y 0.928 Pathogenic MSH6 P52701 Q4A 4 Q A 0.1 Neutral MSH6 P52701 Q4C 4 Q C 0.082 Neutral MSH6 P52701 Q4D 4 Q D 0.088 Neutral MSH6 P52701 Q4E 4 Q E 0.086 Neutral MSH6 P52701 Q4F 4 Q F 0.268 Neutral MSH6 P52701 Q4G 4 Q G 0.118 Neutral MSH6 P52701 Q4H 4 Q H 0.216 Neutral MSH6 P52701 Q4I 4 Q I 0.286 Neutral MSH6 P52701 Q4K 4 Q K 0.224 Neutral MSH6 P52701 Q4L 4 Q L 0.244 Neutral MSH6 P52701 Q4M 4 Q M 0.188 Neutral MSH6 P52701 Q4N 4 Q N 0.094 Neutral MSH6 P52701 Q4P 4 Q P 0.3 Neutral MSH6 P52701 Q4R 4 Q R 0.04 Neutral MSH6 P52701 Q4S 4 Q S 0.178 Neutral MSH6 P52701 Q4T 4 Q T 0.132 Neutral MSH6 P52701 Q4V 4 Q V 0.274 Neutral MSH6 P52701 Q4W 4 Q W 0.432 Neutral MSH6 P52701 Q4Y 4 Q Y 0.38 Neutral MSH6 P52701 A40C 40 A C 0.182 Neutral MSH6 P52701 A40D 40 A D 0.266 Neutral MSH6 P52701 A40E 40 A E 0.306 Neutral MSH6 P52701 A40F 40 A F 0.468 Neutral MSH6 P52701 A40G 40 A G 0.154 Neutral MSH6 P52701 A40H 40 A H 0.304 Neutral MSH6 P52701 A40I 40 A I 0.406 Neutral MSH6 P52701 A40K 40 A K 0.354 Neutral MSH6 P52701 A40L 40 A L 0.414 Neutral MSH6 P52701 A40M 40 A M 0.256 Neutral MSH6 P52701 A40N 40 A N 0.296 Neutral MSH6 P52701 A40P 40 A P 0.138 Neutral MSH6 P52701 A40Q 40 A Q 0.302 Neutral MSH6 P52701 A40R 40 A R 0.36 Neutral MSH6 P52701 A40S 40 A S 0.008 Neutral MSH6 P52701 A40T 40 A T 0.03 Neutral MSH6 P52701 A40V 40 A V 0.042 Neutral MSH6 P52701 A40W 40 A W 0.504 Pathogenic MSH6 P52701 A40Y 40 A Y 0.5 Pathogenic MSH6 P52701 E400A 400 E A 0.208 Neutral MSH6 P52701 E400C 400 E C 0.494 Neutral MSH6 P52701 E400D 400 E D 0.012 Neutral MSH6 P52701 E400F 400 E F 0.876 Pathogenic MSH6 P52701 E400G 400 E G 0.16 Neutral MSH6 P52701 E400H 400 E H 0.604 Pathogenic MSH6 P52701 E400I 400 E I 0.938 Pathogenic MSH6 P52701 E400K 400 E K 0.146 Neutral MSH6 P52701 E400L 400 E L 0.424 Neutral MSH6 P52701 E400M 400 E M 0.71 Pathogenic MSH6 P52701 E400N 400 E N 0.034 Neutral MSH6 P52701 E400P 400 E P 0.306 Neutral MSH6 P52701 E400Q 400 E Q 0.014 Neutral MSH6 P52701 E400R 400 E R 0.402 Neutral MSH6 P52701 E400S 400 E S 0.046 Neutral MSH6 P52701 E400T 400 E T 0.236 Neutral MSH6 P52701 E400V 400 E V 0.406 Neutral MSH6 P52701 E400W 400 E W 0.928 Pathogenic MSH6 P52701 E400Y 400 E Y 0.884 Pathogenic MSH6 P52701 D401A 401 D A 0.154 Neutral MSH6 P52701 D401C 401 D C 0.674 Pathogenic MSH6 P52701 D401E 401 D E 0.028 Neutral MSH6 P52701 D401F 401 D F 0.88 Pathogenic MSH6 P52701 D401G 401 D G 0.076 Neutral MSH6 P52701 D401H 401 D H 0.554 Pathogenic MSH6 P52701 D401I 401 D I 0.842 Pathogenic MSH6 P52701 D401K 401 D K 0.08 Neutral MSH6 P52701 D401L 401 D L 0.124 Neutral MSH6 P52701 D401M 401 D M 0.126 Neutral MSH6 P52701 D401N 401 D N 0.036 Neutral MSH6 P52701 D401P 401 D P 0.78 Pathogenic MSH6 P52701 D401Q 401 D Q 0.03 Neutral MSH6 P52701 D401R 401 D R 0.586 Pathogenic MSH6 P52701 D401S 401 D S 0.024 Neutral MSH6 P52701 D401T 401 D T 0.356 Neutral MSH6 P52701 D401V 401 D V 0.832 Pathogenic MSH6 P52701 D401W 401 D W 0.938 Pathogenic MSH6 P52701 D401Y 401 D Y 0.788 Pathogenic MSH6 P52701 F402A 402 F A 0.132 Neutral MSH6 P52701 F402C 402 F C 0.162 Neutral MSH6 P52701 F402D 402 F D 0.222 Neutral MSH6 P52701 F402E 402 F E 0.244 Neutral MSH6 P52701 F402G 402 F G 0.486 Neutral MSH6 P52701 F402H 402 F H 0.638 Pathogenic MSH6 P52701 F402I 402 F I 0.562 Pathogenic MSH6 P52701 F402K 402 F K 0.228 Neutral MSH6 P52701 F402L 402 F L 0.546 Pathogenic MSH6 P52701 F402M 402 F M 0.66 Pathogenic MSH6 P52701 F402N 402 F N 0.712 Pathogenic MSH6 P52701 F402P 402 F P 0.944 Pathogenic MSH6 P52701 F402Q 402 F Q 0.45 Neutral MSH6 P52701 F402R 402 F R 0.92 Pathogenic MSH6 P52701 F402S 402 F S 0.76 Pathogenic MSH6 P52701 F402T 402 F T 0.356 Neutral MSH6 P52701 F402V 402 F V 0.834 Pathogenic MSH6 P52701 F402W 402 F W 0.938 Pathogenic MSH6 P52701 F402Y 402 F Y 0.238 Neutral MSH6 P52701 L403A 403 L A 0.202 Neutral MSH6 P52701 L403C 403 L C 0.65 Pathogenic MSH6 P52701 L403D 403 L D 0.922 Pathogenic MSH6 P52701 L403E 403 L E 0.192 Neutral MSH6 P52701 L403F 403 L F 0.594 Pathogenic MSH6 P52701 L403G 403 L G 0.816 Pathogenic MSH6 P52701 L403H 403 L H 0.16 Neutral MSH6 P52701 L403I 403 L I 0.188 Neutral MSH6 P52701 L403K 403 L K 0.138 Neutral MSH6 P52701 L403M 403 L M 0.162 Neutral MSH6 P52701 L403N 403 L N 0.8 Pathogenic MSH6 P52701 L403P 403 L P 0.944 Pathogenic MSH6 P52701 L403Q 403 L Q 0.572 Pathogenic MSH6 P52701 L403R 403 L R 0.728 Pathogenic MSH6 P52701 L403S 403 L S 0.37 Neutral MSH6 P52701 L403T 403 L T 0.518 Pathogenic MSH6 P52701 L403V 403 L V 0.104 Neutral MSH6 P52701 L403W 403 L W 0.6 Pathogenic MSH6 P52701 L403Y 403 L Y 0.722 Pathogenic MSH6 P52701 N404A 404 N A 0.11 Neutral MSH6 P52701 N404C 404 N C 0.554 Pathogenic MSH6 P52701 N404D 404 N D 0.068 Neutral MSH6 P52701 N404E 404 N E 0.09 Neutral MSH6 P52701 N404F 404 N F 0.882 Pathogenic MSH6 P52701 N404G 404 N G 0.354 Neutral MSH6 P52701 N404H 404 N H 0.754 Pathogenic MSH6 P52701 N404I 404 N I 0.466 Neutral MSH6 P52701 N404K 404 N K 0.106 Neutral MSH6 P52701 N404L 404 N L 0.238 Neutral MSH6 P52701 N404M 404 N M 0.466 Neutral MSH6 P52701 N404P 404 N P 0.732 Pathogenic MSH6 P52701 N404Q 404 N Q 0.054 Neutral MSH6 P52701 N404R 404 N R 0.448 Neutral MSH6 P52701 N404S 404 N S 0.042 Neutral MSH6 P52701 N404T 404 N T 0.056 Neutral MSH6 P52701 N404V 404 N V 0.874 Pathogenic MSH6 P52701 N404W 404 N W 0.94 Pathogenic MSH6 P52701 N404Y 404 N Y 0.926 Pathogenic MSH6 P52701 S405A 405 S A 0.354 Neutral MSH6 P52701 S405C 405 S C 0.52 Pathogenic MSH6 P52701 S405D 405 S D 0.368 Neutral MSH6 P52701 S405E 405 S E 0.454 Neutral MSH6 P52701 S405F 405 S F 0.892 Pathogenic MSH6 P52701 S405G 405 S G 0.204 Neutral MSH6 P52701 S405H 405 S H 0.67 Pathogenic MSH6 P52701 S405I 405 S I 0.588 Pathogenic MSH6 P52701 S405K 405 S K 0.462 Neutral MSH6 P52701 S405L 405 S L 0.652 Pathogenic MSH6 P52701 S405M 405 S M 0.976 Pathogenic MSH6 P52701 S405N 405 S N 0.05 Neutral MSH6 P52701 S405P 405 S P 0.668 Pathogenic MSH6 P52701 S405Q 405 S Q 0.482 Neutral MSH6 P52701 S405R 405 S R 0.488 Neutral MSH6 P52701 S405T 405 S T 0.046 Neutral MSH6 P52701 S405V 405 S V 0.82 Pathogenic MSH6 P52701 S405W 405 S W 0.95 Pathogenic MSH6 P52701 S405Y 405 S Y 0.934 Pathogenic MSH6 P52701 C406A 406 C A 0.098 Neutral MSH6 P52701 C406D 406 C D 0.118 Neutral MSH6 P52701 C406E 406 C E 0.22 Neutral MSH6 P52701 C406F 406 C F 0.666 Pathogenic MSH6 P52701 C406G 406 C G 0.238 Neutral MSH6 P52701 C406H 406 C H 0.372 Neutral MSH6 P52701 C406I 406 C I 0.094 Neutral MSH6 P52701 C406K 406 C K 0.354 Neutral MSH6 P52701 C406L 406 C L 0.044 Neutral MSH6 P52701 C406M 406 C M 0.296 Neutral MSH6 P52701 C406N 406 C N 0.04 Neutral MSH6 P52701 C406P 406 C P 0.438 Neutral MSH6 P52701 C406Q 406 C Q 0.008 Neutral MSH6 P52701 C406R 406 C R 0.478 Neutral MSH6 P52701 C406S 406 C S 0.242 Neutral MSH6 P52701 C406T 406 C T 0.016 Neutral MSH6 P52701 C406V 406 C V 0.062 Neutral MSH6 P52701 C406W 406 C W 0.74 Pathogenic MSH6 P52701 C406Y 406 C Y 0.708 Pathogenic MSH6 P52701 T407A 407 T A 0.408 Neutral MSH6 P52701 T407C 407 T C 0.454 Neutral MSH6 P52701 T407D 407 T D 0.47 Neutral MSH6 P52701 T407E 407 T E 0.56 Pathogenic MSH6 P52701 T407F 407 T F 0.696 Pathogenic MSH6 P52701 T407G 407 T G 0.272 Neutral MSH6 P52701 T407H 407 T H 0.528 Pathogenic MSH6 P52701 T407I 407 T I 0.508 Pathogenic MSH6 P52701 T407K 407 T K 0.494 Neutral MSH6 P52701 T407L 407 T L 0.51 Pathogenic MSH6 P52701 T407M 407 T M 0.63 Pathogenic MSH6 P52701 T407N 407 T N 0.282 Neutral MSH6 P52701 T407P 407 T P 0.6 Pathogenic MSH6 P52701 T407Q 407 T Q 0.306 Neutral MSH6 P52701 T407R 407 T R 0.772 Pathogenic MSH6 P52701 T407S 407 T S 0.024 Neutral MSH6 P52701 T407V 407 T V 0.71 Pathogenic MSH6 P52701 T407W 407 T W 0.914 Pathogenic MSH6 P52701 T407Y 407 T Y 0.908 Pathogenic MSH6 P52701 P408A 408 P A 0.172 Neutral MSH6 P52701 P408C 408 P C 0.908 Pathogenic MSH6 P52701 P408D 408 P D 0.242 Neutral MSH6 P52701 P408E 408 P E 0.292 Neutral MSH6 P52701 P408F 408 P F 0.998 Pathogenic MSH6 P52701 P408G 408 P G 0.18 Neutral MSH6 P52701 P408H 408 P H 0.974 Pathogenic MSH6 P52701 P408I 408 P I 0.934 Pathogenic MSH6 P52701 P408K 408 P K 0.944 Pathogenic MSH6 P52701 P408L 408 P L 0.992 Pathogenic MSH6 P52701 P408M 408 P M 0.954 Pathogenic MSH6 P52701 P408N 408 P N 0.42 Neutral MSH6 P52701 P408Q 408 P Q 0.546 Pathogenic MSH6 P52701 P408R 408 P R 0.978 Pathogenic MSH6 P52701 P408S 408 P S 0.314 Neutral MSH6 P52701 P408T 408 P T 0.364 Neutral MSH6 P52701 P408V 408 P V 0.846 Pathogenic MSH6 P52701 P408W 408 P W 0.932 Pathogenic MSH6 P52701 P408Y 408 P Y 0.928 Pathogenic MSH6 P52701 G409A 409 G A 0.32 Neutral MSH6 P52701 G409C 409 G C 0.934 Pathogenic MSH6 P52701 G409D 409 G D 0.974 Pathogenic MSH6 P52701 G409E 409 G E 0.984 Pathogenic MSH6 P52701 G409F 409 G F 0.726 Pathogenic MSH6 P52701 G409H 409 G H 0.992 Pathogenic MSH6 P52701 G409I 409 G I 0.978 Pathogenic MSH6 P52701 G409K 409 G K 0.992 Pathogenic MSH6 P52701 G409L 409 G L 0.812 Pathogenic MSH6 P52701 G409M 409 G M 0.994 Pathogenic MSH6 P52701 G409N 409 G N 0.938 Pathogenic MSH6 P52701 G409P 409 G P 0.982 Pathogenic MSH6 P52701 G409Q 409 G Q 0.978 Pathogenic MSH6 P52701 G409R 409 G R 1 Pathogenic MSH6 P52701 G409S 409 G S 0.962 Pathogenic MSH6 P52701 G409T 409 G T 0.92 Pathogenic MSH6 P52701 G409V 409 G V 0.99 Pathogenic MSH6 P52701 G409W 409 G W 0.984 Pathogenic MSH6 P52701 G409Y 409 G Y 0.984 Pathogenic MSH6 P52701 S41A 41 S A 0.01 Neutral MSH6 P52701 S41C 41 S C 0.032 Neutral MSH6 P52701 S41D 41 S D 0.024 Neutral MSH6 P52701 S41E 41 S E 0.122 Neutral MSH6 P52701 S41F 41 S F 0.276 Neutral MSH6 P52701 S41G 41 S G 0.036 Neutral MSH6 P52701 S41H 41 S H 0.238 Neutral MSH6 P52701 S41I 41 S I 0.026 Neutral MSH6 P52701 S41K 41 S K 0.15 Neutral MSH6 P52701 S41L 41 S L 0.028 Neutral MSH6 P52701 S41M 41 S M 0.332 Neutral MSH6 P52701 S41N 41 S N 0.012 Neutral MSH6 P52701 S41P 41 S P 0.062 Neutral MSH6 P52701 S41Q 41 S Q 0.158 Neutral MSH6 P52701 S41R 41 S R 0.17 Neutral MSH6 P52701 S41T 41 S T 0.11 Neutral MSH6 P52701 S41V 41 S V 0.248 Neutral MSH6 P52701 S41W 41 S W 0.49 Neutral MSH6 P52701 S41Y 41 S Y 0.448 Neutral MSH6 P52701 M410A 410 M A 0.366 Neutral MSH6 P52701 M410C 410 M C 0.28 Neutral MSH6 P52701 M410D 410 M D 0.69 Pathogenic MSH6 P52701 M410E 410 M E 0.052 Neutral MSH6 P52701 M410F 410 M F 0.702 Pathogenic MSH6 P52701 M410G 410 M G 0.376 Neutral MSH6 P52701 M410H 410 M H 0.07 Neutral MSH6 P52701 M410I 410 M I 0.602 Pathogenic MSH6 P52701 M410K 410 M K 0.692 Pathogenic MSH6 P52701 M410L 410 M L 0.118 Neutral MSH6 P52701 M410N 410 M N 0.726 Pathogenic MSH6 P52701 M410P 410 M P 0.83 Pathogenic MSH6 P52701 M410Q 410 M Q 0.046 Neutral MSH6 P52701 M410R 410 M R 0.748 Pathogenic MSH6 P52701 M410S 410 M S 0.518 Pathogenic MSH6 P52701 M410T 410 M T 0.36 Neutral MSH6 P52701 M410V 410 M V 0.12 Neutral MSH6 P52701 M410W 410 M W 0.916 Pathogenic MSH6 P52701 M410Y 410 M Y 0.84 Pathogenic MSH6 P52701 R411A 411 R A 0.266 Neutral MSH6 P52701 R411C 411 R C 0.948 Pathogenic MSH6 P52701 R411D 411 R D 0.86 Pathogenic MSH6 P52701 R411E 411 R E 0.836 Pathogenic MSH6 P52701 R411F 411 R F 0.972 Pathogenic MSH6 P52701 R411G 411 R G 0.14 Neutral MSH6 P52701 R411H 411 R H 0.19 Neutral MSH6 P52701 R411I 411 R I 0.714 Pathogenic MSH6 P52701 R411K 411 R K 0.404 Neutral MSH6 P52701 R411L 411 R L 0.984 Pathogenic MSH6 P52701 R411M 411 R M 0.802 Pathogenic MSH6 P52701 R411N 411 R N 0.754 Pathogenic MSH6 P52701 R411P 411 R P 0.984 Pathogenic MSH6 P52701 R411Q 411 R Q 0.104 Neutral MSH6 P52701 R411S 411 R S 0.868 Pathogenic MSH6 P52701 R411T 411 R T 0.184 Neutral MSH6 P52701 R411V 411 R V 0.346 Neutral MSH6 P52701 R411W 411 R W 0.972 Pathogenic MSH6 P52701 R411Y 411 R Y 0.814 Pathogenic MSH6 P52701 K412A 412 K A 0.644 Pathogenic MSH6 P52701 K412C 412 K C 0.53 Pathogenic MSH6 P52701 K412D 412 K D 0.712 Pathogenic MSH6 P52701 K412E 412 K E 0.826 Pathogenic MSH6 P52701 K412F 412 K F 0.974 Pathogenic MSH6 P52701 K412G 412 K G 0.532 Pathogenic MSH6 P52701 K412H 412 K H 0.826 Pathogenic MSH6 P52701 K412I 412 K I 0.99 Pathogenic MSH6 P52701 K412L 412 K L 0.98 Pathogenic MSH6 P52701 K412M 412 K M 0.93 Pathogenic MSH6 P52701 K412N 412 K N 0.322 Neutral MSH6 P52701 K412P 412 K P 0.926 Pathogenic MSH6 P52701 K412Q 412 K Q 0.15 Neutral MSH6 P52701 K412R 412 K R 0.188 Neutral MSH6 P52701 K412S 412 K S 0.726 Pathogenic MSH6 P52701 K412T 412 K T 0.664 Pathogenic MSH6 P52701 K412V 412 K V 0.89 Pathogenic MSH6 P52701 K412W 412 K W 0.992 Pathogenic MSH6 P52701 K412Y 412 K Y 0.984 Pathogenic MSH6 P52701 W413A 413 W A 0.468 Neutral MSH6 P52701 W413C 413 W C 0.472 Neutral MSH6 P52701 W413D 413 W D 0.5 Pathogenic MSH6 P52701 W413E 413 W E 0.81 Pathogenic MSH6 P52701 W413F 413 W F 0.164 Neutral MSH6 P52701 W413G 413 W G 0.46 Neutral MSH6 P52701 W413H 413 W H 0.718 Pathogenic MSH6 P52701 W413I 413 W I 0.562 Pathogenic MSH6 P52701 W413K 413 W K 0.902 Pathogenic MSH6 P52701 W413L 413 W L 0.512 Pathogenic MSH6 P52701 W413M 413 W M 0.72 Pathogenic MSH6 P52701 W413N 413 W N 0.47 Neutral MSH6 P52701 W413P 413 W P 0.546 Pathogenic MSH6 P52701 W413Q 413 W Q 0.62 Pathogenic MSH6 P52701 W413R 413 W R 0.696 Pathogenic MSH6 P52701 W413S 413 W S 0.476 Neutral MSH6 P52701 W413T 413 W T 0.468 Neutral MSH6 P52701 W413V 413 W V 0.482 Neutral MSH6 P52701 W413Y 413 W Y 0.16 Neutral MSH6 P52701 W414A 414 W A 0.466 Neutral MSH6 P52701 W414C 414 W C 0.47 Neutral MSH6 P52701 W414D 414 W D 0.496 Neutral MSH6 P52701 W414E 414 W E 0.84 Pathogenic MSH6 P52701 W414F 414 W F 0.712 Pathogenic MSH6 P52701 W414G 414 W G 0.466 Neutral MSH6 P52701 W414H 414 W H 0.722 Pathogenic MSH6 P52701 W414I 414 W I 0.534 Pathogenic MSH6 P52701 W414K 414 W K 0.892 Pathogenic MSH6 P52701 W414L 414 W L 0.478 Neutral MSH6 P52701 W414M 414 W M 0.72 Pathogenic MSH6 P52701 W414N 414 W N 0.476 Neutral MSH6 P52701 W414P 414 W P 0.494 Neutral MSH6 P52701 W414Q 414 W Q 0.656 Pathogenic MSH6 P52701 W414R 414 W R 0.734 Pathogenic MSH6 P52701 W414S 414 W S 0.476 Neutral MSH6 P52701 W414T 414 W T 0.466 Neutral MSH6 P52701 W414V 414 W V 0.406 Neutral MSH6 P52701 W414Y 414 W Y 0.716 Pathogenic MSH6 P52701 Q415A 415 Q A 0.244 Neutral MSH6 P52701 Q415C 415 Q C 0.566 Pathogenic MSH6 P52701 Q415D 415 Q D 0.122 Neutral MSH6 P52701 Q415E 415 Q E 0.374 Neutral MSH6 P52701 Q415F 415 Q F 0.812 Pathogenic MSH6 P52701 Q415G 415 Q G 0.436 Neutral MSH6 P52701 Q415H 415 Q H 0.79 Pathogenic MSH6 P52701 Q415I 415 Q I 0.496 Neutral MSH6 P52701 Q415K 415 Q K 0.302 Neutral MSH6 P52701 Q415L 415 Q L 0.442 Neutral MSH6 P52701 Q415M 415 Q M 0.728 Pathogenic MSH6 P52701 Q415N 415 Q N 0.338 Neutral MSH6 P52701 Q415P 415 Q P 0.828 Pathogenic MSH6 P52701 Q415R 415 Q R 0.698 Pathogenic MSH6 P52701 Q415S 415 Q S 0.638 Pathogenic MSH6 P52701 Q415T 415 Q T 0.188 Neutral MSH6 P52701 Q415V 415 Q V 0.296 Neutral MSH6 P52701 Q415W 415 Q W 0.88 Pathogenic MSH6 P52701 Q415Y 415 Q Y 0.858 Pathogenic MSH6 P52701 I416A 416 I A 0.118 Neutral MSH6 P52701 I416C 416 I C 0.612 Pathogenic MSH6 P52701 I416D 416 I D 0.778 Pathogenic MSH6 P52701 I416E 416 I E 0.778 Pathogenic MSH6 P52701 I416F 416 I F 0.288 Neutral MSH6 P52701 I416G 416 I G 0.814 Pathogenic MSH6 P52701 I416H 416 I H 0.798 Pathogenic MSH6 P52701 I416K 416 I K 0.832 Pathogenic MSH6 P52701 I416L 416 I L 0.116 Neutral MSH6 P52701 I416M 416 I M 0.156 Neutral MSH6 P52701 I416N 416 I N 0.804 Pathogenic MSH6 P52701 I416P 416 I P 0.89 Pathogenic MSH6 P52701 I416Q 416 I Q 0.808 Pathogenic MSH6 P52701 I416R 416 I R 0.884 Pathogenic MSH6 P52701 I416S 416 I S 0.566 Pathogenic MSH6 P52701 I416T 416 I T 0.352 Neutral MSH6 P52701 I416V 416 I V 0.126 Neutral MSH6 P52701 I416W 416 I W 0.88 Pathogenic MSH6 P52701 I416Y 416 I Y 0.876 Pathogenic MSH6 P52701 K417A 417 K A 0.696 Pathogenic MSH6 P52701 K417C 417 K C 0.602 Pathogenic MSH6 P52701 K417D 417 K D 0.772 Pathogenic MSH6 P52701 K417E 417 K E 0.87 Pathogenic MSH6 P52701 K417F 417 K F 0.952 Pathogenic MSH6 P52701 K417G 417 K G 0.512 Pathogenic MSH6 P52701 K417H 417 K H 0.876 Pathogenic MSH6 P52701 K417I 417 K I 0.986 Pathogenic MSH6 P52701 K417L 417 K L 0.978 Pathogenic MSH6 P52701 K417M 417 K M 0.878 Pathogenic MSH6 P52701 K417N 417 K N 0.786 Pathogenic MSH6 P52701 K417P 417 K P 0.912 Pathogenic MSH6 P52701 K417Q 417 K Q 0.854 Pathogenic MSH6 P52701 K417R 417 K R 0.86 Pathogenic MSH6 P52701 K417S 417 K S 0.624 Pathogenic MSH6 P52701 K417T 417 K T 0.648 Pathogenic MSH6 P52701 K417V 417 K V 0.846 Pathogenic MSH6 P52701 K417W 417 K W 0.984 Pathogenic MSH6 P52701 K417Y 417 K Y 0.974 Pathogenic MSH6 P52701 S418A 418 S A 0.16 Neutral MSH6 P52701 S418C 418 S C 0.29 Neutral MSH6 P52701 S418D 418 S D 0.804 Pathogenic MSH6 P52701 S418E 418 S E 0.91 Pathogenic MSH6 P52701 S418F 418 S F 0.976 Pathogenic MSH6 P52701 S418G 418 S G 0.546 Pathogenic MSH6 P52701 S418H 418 S H 0.696 Pathogenic MSH6 P52701 S418I 418 S I 0.856 Pathogenic MSH6 P52701 S418K 418 S K 0.536 Pathogenic MSH6 P52701 S418L 418 S L 0.882 Pathogenic MSH6 P52701 S418M 418 S M 0.866 Pathogenic MSH6 P52701 S418N 418 S N 0.766 Pathogenic MSH6 P52701 S418P 418 S P 0.918 Pathogenic MSH6 P52701 S418Q 418 S Q 0.468 Neutral MSH6 P52701 S418R 418 S R 0.616 Pathogenic MSH6 P52701 S418T 418 S T 0.76 Pathogenic MSH6 P52701 S418V 418 S V 0.798 Pathogenic MSH6 P52701 S418W 418 S W 0.984 Pathogenic MSH6 P52701 S418Y 418 S Y 0.98 Pathogenic MSH6 P52701 Q419A 419 Q A 0.166 Neutral MSH6 P52701 Q419C 419 Q C 0.49 Neutral MSH6 P52701 Q419D 419 Q D 0.046 Neutral MSH6 P52701 Q419E 419 Q E 0.054 Neutral MSH6 P52701 Q419F 419 Q F 0.846 Pathogenic MSH6 P52701 Q419G 419 Q G 0.396 Neutral MSH6 P52701 Q419H 419 Q H 0.238 Neutral MSH6 P52701 Q419I 419 Q I 0.898 Pathogenic MSH6 P52701 Q419K 419 Q K 0.114 Neutral MSH6 P52701 Q419L 419 Q L 0.766 Pathogenic MSH6 P52701 Q419M 419 Q M 0.746 Pathogenic MSH6 P52701 Q419N 419 Q N 0.094 Neutral MSH6 P52701 Q419P 419 Q P 0.86 Pathogenic MSH6 P52701 Q419R 419 Q R 0.09 Neutral MSH6 P52701 Q419S 419 Q S 0.532 Pathogenic MSH6 P52701 Q419T 419 Q T 0.07 Neutral MSH6 P52701 Q419V 419 Q V 0.848 Pathogenic MSH6 P52701 Q419W 419 Q W 0.932 Pathogenic MSH6 P52701 Q419Y 419 Q Y 0.894 Pathogenic MSH6 P52701 P42A 42 P A 0.116 Neutral MSH6 P52701 P42C 42 P C 0.148 Neutral MSH6 P52701 P42D 42 P D 0.05 Neutral MSH6 P52701 P42E 42 P E 0.214 Neutral MSH6 P52701 P42F 42 P F 0.226 Neutral MSH6 P52701 P42G 42 P G 0.066 Neutral MSH6 P52701 P42H 42 P H 0.266 Neutral MSH6 P52701 P42I 42 P I 0.104 Neutral MSH6 P52701 P42K 42 P K 0.05 Neutral MSH6 P52701 P42L 42 P L 0.094 Neutral MSH6 P52701 P42M 42 P M 0.22 Neutral MSH6 P52701 P42N 42 P N 0.048 Neutral MSH6 P52701 P42Q 42 P Q 0.212 Neutral MSH6 P52701 P42R 42 P R 0.204 Neutral MSH6 P52701 P42S 42 P S 0.002 Neutral MSH6 P52701 P42T 42 P T 0.034 Neutral MSH6 P52701 P42V 42 P V 0.184 Neutral MSH6 P52701 P42W 42 P W 0.39 Neutral MSH6 P52701 P42Y 42 P Y 0.32 Neutral MSH6 P52701 N420A 420 N A 0.348 Neutral MSH6 P52701 N420C 420 N C 0.604 Pathogenic MSH6 P52701 N420D 420 N D 0.582 Pathogenic MSH6 P52701 N420E 420 N E 0.532 Pathogenic MSH6 P52701 N420F 420 N F 0.418 Neutral MSH6 P52701 N420G 420 N G 0.622 Pathogenic MSH6 P52701 N420H 420 N H 0.07 Neutral MSH6 P52701 N420I 420 N I 0.894 Pathogenic MSH6 P52701 N420K 420 N K 0.82 Pathogenic MSH6 P52701 N420L 420 N L 0.156 Neutral MSH6 P52701 N420M 420 N M 0.106 Neutral MSH6 P52701 N420P 420 N P 0.77 Pathogenic MSH6 P52701 N420Q 420 N Q 0.656 Pathogenic MSH6 P52701 N420R 420 N R 0.758 Pathogenic MSH6 P52701 N420S 420 N S 0.65 Pathogenic MSH6 P52701 N420T 420 N T 0.568 Pathogenic MSH6 P52701 N420V 420 N V 0.932 Pathogenic MSH6 P52701 N420W 420 N W 0.806 Pathogenic MSH6 P52701 N420Y 420 N Y 0.722 Pathogenic MSH6 P52701 F421A 421 F A 0.184 Neutral MSH6 P52701 F421C 421 F C 0.552 Pathogenic MSH6 P52701 F421D 421 F D 0.818 Pathogenic MSH6 P52701 F421E 421 F E 0.92 Pathogenic MSH6 P52701 F421G 421 F G 0.5 Pathogenic MSH6 P52701 F421H 421 F H 0.604 Pathogenic MSH6 P52701 F421I 421 F I 0.516 Pathogenic MSH6 P52701 F421K 421 F K 0.88 Pathogenic MSH6 P52701 F421L 421 F L 0.176 Neutral MSH6 P52701 F421M 421 F M 0.102 Neutral MSH6 P52701 F421N 421 F N 0.49 Neutral MSH6 P52701 F421P 421 F P 0.866 Pathogenic MSH6 P52701 F421Q 421 F Q 0.788 Pathogenic MSH6 P52701 F421R 421 F R 0.924 Pathogenic MSH6 P52701 F421S 421 F S 0.664 Pathogenic MSH6 P52701 F421T 421 F T 0.384 Neutral MSH6 P52701 F421V 421 F V 0.684 Pathogenic MSH6 P52701 F421W 421 F W 0.638 Pathogenic MSH6 P52701 F421Y 421 F Y 0.206 Neutral MSH6 P52701 D422A 422 D A 0.79 Pathogenic MSH6 P52701 D422C 422 D C 0.878 Pathogenic MSH6 P52701 D422E 422 D E 0.658 Pathogenic MSH6 P52701 D422F 422 D F 0.98 Pathogenic MSH6 P52701 D422G 422 D G 0.932 Pathogenic MSH6 P52701 D422H 422 D H 0.626 Pathogenic MSH6 P52701 D422I 422 D I 0.974 Pathogenic MSH6 P52701 D422K 422 D K 0.924 Pathogenic MSH6 P52701 D422L 422 D L 0.976 Pathogenic MSH6 P52701 D422M 422 D M 0.956 Pathogenic MSH6 P52701 D422N 422 D N 0.378 Neutral MSH6 P52701 D422P 422 D P 0.904 Pathogenic MSH6 P52701 D422Q 422 D Q 0.616 Pathogenic MSH6 P52701 D422R 422 D R 0.958 Pathogenic MSH6 P52701 D422S 422 D S 0.562 Pathogenic MSH6 P52701 D422T 422 D T 0.796 Pathogenic MSH6 P52701 D422V 422 D V 0.996 Pathogenic MSH6 P52701 D422W 422 D W 0.98 Pathogenic MSH6 P52701 D422Y 422 D Y 0.974 Pathogenic MSH6 P52701 L423A 423 L A 0.04 Neutral MSH6 P52701 L423C 423 L C 0.024 Neutral MSH6 P52701 L423D 423 L D 0.676 Pathogenic MSH6 P52701 L423E 423 L E 0.63 Pathogenic MSH6 P52701 L423F 423 L F 0.796 Pathogenic MSH6 P52701 L423G 423 L G 0.448 Neutral MSH6 P52701 L423H 423 L H 0.424 Neutral MSH6 P52701 L423I 423 L I 0.578 Pathogenic MSH6 P52701 L423K 423 L K 0.036 Neutral MSH6 P52701 L423M 423 L M 0.468 Neutral MSH6 P52701 L423N 423 L N 0.622 Pathogenic MSH6 P52701 L423P 423 L P 0.954 Pathogenic MSH6 P52701 L423Q 423 L Q 0.364 Neutral MSH6 P52701 L423R 423 L R 0.872 Pathogenic MSH6 P52701 L423S 423 L S 0.048 Neutral MSH6 P52701 L423T 423 L T 0.162 Neutral MSH6 P52701 L423V 423 L V 0.002 Neutral MSH6 P52701 L423W 423 L W 0.848 Pathogenic MSH6 P52701 L423Y 423 L Y 0.84 Pathogenic MSH6 P52701 V424A 424 V A 0.496 Neutral MSH6 P52701 V424C 424 V C 0.798 Pathogenic MSH6 P52701 V424D 424 V D 0.852 Pathogenic MSH6 P52701 V424E 424 V E 0.954 Pathogenic MSH6 P52701 V424F 424 V F 0.932 Pathogenic MSH6 P52701 V424G 424 V G 0.922 Pathogenic MSH6 P52701 V424H 424 V H 0.898 Pathogenic MSH6 P52701 V424I 424 V I 0.242 Neutral MSH6 P52701 V424K 424 V K 0.974 Pathogenic MSH6 P52701 V424L 424 V L 0.322 Neutral MSH6 P52701 V424M 424 V M 0.364 Neutral MSH6 P52701 V424N 424 V N 0.912 Pathogenic MSH6 P52701 V424P 424 V P 0.988 Pathogenic MSH6 P52701 V424Q 424 V Q 0.96 Pathogenic MSH6 P52701 V424R 424 V R 0.944 Pathogenic MSH6 P52701 V424S 424 V S 0.808 Pathogenic MSH6 P52701 V424T 424 V T 0.88 Pathogenic MSH6 P52701 V424W 424 V W 0.956 Pathogenic MSH6 P52701 V424Y 424 V Y 0.976 Pathogenic MSH6 P52701 I425A 425 I A 0.476 Neutral MSH6 P52701 I425C 425 I C 0.616 Pathogenic MSH6 P52701 I425D 425 I D 0.762 Pathogenic MSH6 P52701 I425E 425 I E 0.766 Pathogenic MSH6 P52701 I425F 425 I F 0.324 Neutral MSH6 P52701 I425G 425 I G 0.81 Pathogenic MSH6 P52701 I425H 425 I H 0.844 Pathogenic MSH6 P52701 I425K 425 I K 0.856 Pathogenic MSH6 P52701 I425L 425 I L 0.214 Neutral MSH6 P52701 I425M 425 I M 0.686 Pathogenic MSH6 P52701 I425N 425 I N 0.79 Pathogenic MSH6 P52701 I425P 425 I P 0.938 Pathogenic MSH6 P52701 I425Q 425 I Q 0.8 Pathogenic MSH6 P52701 I425R 425 I R 0.884 Pathogenic MSH6 P52701 I425S 425 I S 0.626 Pathogenic MSH6 P52701 I425T 425 I T 0.368 Neutral MSH6 P52701 I425V 425 I V 0.132 Neutral MSH6 P52701 I425W 425 I W 0.982 Pathogenic MSH6 P52701 I425Y 425 I Y 0.976 Pathogenic MSH6 P52701 C426A 426 C A 0.726 Pathogenic MSH6 P52701 C426D 426 C D 0.944 Pathogenic MSH6 P52701 C426E 426 C E 0.82 Pathogenic MSH6 P52701 C426F 426 C F 0.678 Pathogenic MSH6 P52701 C426G 426 C G 0.934 Pathogenic MSH6 P52701 C426H 426 C H 0.776 Pathogenic MSH6 P52701 C426I 426 C I 0.934 Pathogenic MSH6 P52701 C426K 426 C K 0.858 Pathogenic MSH6 P52701 C426L 426 C L 0.366 Neutral MSH6 P52701 C426M 426 C M 0.668 Pathogenic MSH6 P52701 C426N 426 C N 0.814 Pathogenic MSH6 P52701 C426P 426 C P 0.958 Pathogenic MSH6 P52701 C426Q 426 C Q 0.554 Pathogenic MSH6 P52701 C426R 426 C R 0.996 Pathogenic MSH6 P52701 C426S 426 C S 0.424 Neutral MSH6 P52701 C426T 426 C T 0.584 Pathogenic MSH6 P52701 C426V 426 C V 0.938 Pathogenic MSH6 P52701 C426W 426 C W 0.964 Pathogenic MSH6 P52701 C426Y 426 C Y 0.952 Pathogenic MSH6 P52701 Y427A 427 Y A 0.442 Neutral MSH6 P52701 Y427C 427 Y C 0.362 Neutral MSH6 P52701 Y427D 427 Y D 0.838 Pathogenic MSH6 P52701 Y427E 427 Y E 0.738 Pathogenic MSH6 P52701 Y427F 427 Y F 0.158 Neutral MSH6 P52701 Y427G 427 Y G 0.49 Neutral MSH6 P52701 Y427H 427 Y H 0.592 Pathogenic MSH6 P52701 Y427I 427 Y I 0.806 Pathogenic MSH6 P52701 Y427K 427 Y K 0.822 Pathogenic MSH6 P52701 Y427L 427 Y L 0.708 Pathogenic MSH6 P52701 Y427M 427 Y M 0.324 Neutral MSH6 P52701 Y427N 427 Y N 0.73 Pathogenic MSH6 P52701 Y427P 427 Y P 0.798 Pathogenic MSH6 P52701 Y427Q 427 Y Q 0.636 Pathogenic MSH6 P52701 Y427R 427 Y R 0.754 Pathogenic MSH6 P52701 Y427S 427 Y S 0.49 Neutral MSH6 P52701 Y427T 427 Y T 0.676 Pathogenic MSH6 P52701 Y427V 427 Y V 0.688 Pathogenic MSH6 P52701 Y427W 427 Y W 0.908 Pathogenic MSH6 P52701 K428A 428 K A 0.702 Pathogenic MSH6 P52701 K428C 428 K C 0.604 Pathogenic MSH6 P52701 K428D 428 K D 0.774 Pathogenic MSH6 P52701 K428E 428 K E 0.876 Pathogenic MSH6 P52701 K428F 428 K F 0.96 Pathogenic MSH6 P52701 K428G 428 K G 0.528 Pathogenic MSH6 P52701 K428H 428 K H 0.882 Pathogenic MSH6 P52701 K428I 428 K I 0.994 Pathogenic MSH6 P52701 K428L 428 K L 0.986 Pathogenic MSH6 P52701 K428M 428 K M 0.888 Pathogenic MSH6 P52701 K428N 428 K N 0.79 Pathogenic MSH6 P52701 K428P 428 K P 0.756 Pathogenic MSH6 P52701 K428Q 428 K Q 0.384 Neutral MSH6 P52701 K428R 428 K R 0.554 Pathogenic MSH6 P52701 K428S 428 K S 0.63 Pathogenic MSH6 P52701 K428T 428 K T 0.658 Pathogenic MSH6 P52701 K428V 428 K V 0.862 Pathogenic MSH6 P52701 K428W 428 K W 0.986 Pathogenic MSH6 P52701 K428Y 428 K Y 0.976 Pathogenic MSH6 P52701 V429A 429 V A 0.35 Neutral MSH6 P52701 V429C 429 V C 0.724 Pathogenic MSH6 P52701 V429D 429 V D 0.872 Pathogenic MSH6 P52701 V429E 429 V E 0.982 Pathogenic MSH6 P52701 V429F 429 V F 0.876 Pathogenic MSH6 P52701 V429G 429 V G 0.904 Pathogenic MSH6 P52701 V429H 429 V H 0.82 Pathogenic MSH6 P52701 V429I 429 V I 0.298 Neutral MSH6 P52701 V429K 429 V K 0.328 Neutral MSH6 P52701 V429L 429 V L 0.248 Neutral MSH6 P52701 V429M 429 V M 0.214 Neutral MSH6 P52701 V429N 429 V N 0.548 Pathogenic MSH6 P52701 V429P 429 V P 0.978 Pathogenic MSH6 P52701 V429Q 429 V Q 0.99 Pathogenic MSH6 P52701 V429R 429 V R 0.96 Pathogenic MSH6 P52701 V429S 429 V S 0.746 Pathogenic MSH6 P52701 V429T 429 V T 0.138 Neutral MSH6 P52701 V429W 429 V W 0.904 Pathogenic MSH6 P52701 V429Y 429 V Y 0.93 Pathogenic MSH6 P52701 S43A 43 S A 0.052 Neutral MSH6 P52701 S43C 43 S C 0.032 Neutral MSH6 P52701 S43D 43 S D 0.024 Neutral MSH6 P52701 S43E 43 S E 0.124 Neutral MSH6 P52701 S43F 43 S F 0.276 Neutral MSH6 P52701 S43G 43 S G 0.036 Neutral MSH6 P52701 S43H 43 S H 0.238 Neutral MSH6 P52701 S43I 43 S I 0.026 Neutral MSH6 P52701 S43K 43 S K 0.164 Neutral MSH6 P52701 S43L 43 S L 0.028 Neutral MSH6 P52701 S43M 43 S M 0.332 Neutral MSH6 P52701 S43N 43 S N 0.034 Neutral MSH6 P52701 S43P 43 S P 0.062 Neutral MSH6 P52701 S43Q 43 S Q 0.158 Neutral MSH6 P52701 S43R 43 S R 0.152 Neutral MSH6 P52701 S43T 43 S T 0.02 Neutral MSH6 P52701 S43V 43 S V 0.248 Neutral MSH6 P52701 S43W 43 S W 0.49 Neutral MSH6 P52701 S43Y 43 S Y 0.448 Neutral MSH6 P52701 G430A 430 G A 0.966 Pathogenic MSH6 P52701 G430C 430 G C 0.948 Pathogenic MSH6 P52701 G430D 430 G D 1 Pathogenic MSH6 P52701 G430E 430 G E 0.988 Pathogenic MSH6 P52701 G430F 430 G F 0.984 Pathogenic MSH6 P52701 G430H 430 G H 0.988 Pathogenic MSH6 P52701 G430I 430 G I 0.974 Pathogenic MSH6 P52701 G430K 430 G K 0.988 Pathogenic MSH6 P52701 G430L 430 G L 0.984 Pathogenic MSH6 P52701 G430M 430 G M 0.994 Pathogenic MSH6 P52701 G430N 430 G N 0.986 Pathogenic MSH6 P52701 G430P 430 G P 0.966 Pathogenic MSH6 P52701 G430Q 430 G Q 0.994 Pathogenic MSH6 P52701 G430R 430 G R 1 Pathogenic MSH6 P52701 G430S 430 G S 0.832 Pathogenic MSH6 P52701 G430T 430 G T 0.846 Pathogenic MSH6 P52701 G430V 430 G V 0.986 Pathogenic MSH6 P52701 G430W 430 G W 0.98 Pathogenic MSH6 P52701 G430Y 430 G Y 0.96 Pathogenic MSH6 P52701 K431A 431 K A 0.71 Pathogenic MSH6 P52701 K431C 431 K C 0.62 Pathogenic MSH6 P52701 K431D 431 K D 0.784 Pathogenic MSH6 P52701 K431E 431 K E 0.882 Pathogenic MSH6 P52701 K431F 431 K F 0.958 Pathogenic MSH6 P52701 K431G 431 K G 0.524 Pathogenic MSH6 P52701 K431H 431 K H 0.886 Pathogenic MSH6 P52701 K431I 431 K I 0.99 Pathogenic MSH6 P52701 K431L 431 K L 0.982 Pathogenic MSH6 P52701 K431M 431 K M 0.894 Pathogenic MSH6 P52701 K431N 431 K N 0.796 Pathogenic MSH6 P52701 K431P 431 K P 0.924 Pathogenic MSH6 P52701 K431Q 431 K Q 0.862 Pathogenic MSH6 P52701 K431R 431 K R 0.862 Pathogenic MSH6 P52701 K431S 431 K S 0.646 Pathogenic MSH6 P52701 K431T 431 K T 0.676 Pathogenic MSH6 P52701 K431V 431 K V 0.674 Pathogenic MSH6 P52701 K431W 431 K W 0.986 Pathogenic MSH6 P52701 K431Y 431 K Y 0.976 Pathogenic MSH6 P52701 F432A 432 F A 0.502 Pathogenic MSH6 P52701 F432C 432 F C 0.732 Pathogenic MSH6 P52701 F432D 432 F D 0.82 Pathogenic MSH6 P52701 F432E 432 F E 0.874 Pathogenic MSH6 P52701 F432G 432 F G 0.504 Pathogenic MSH6 P52701 F432H 432 F H 0.782 Pathogenic MSH6 P52701 F432I 432 F I 0.692 Pathogenic MSH6 P52701 F432K 432 F K 0.854 Pathogenic MSH6 P52701 F432L 432 F L 0.706 Pathogenic MSH6 P52701 F432M 432 F M 0.796 Pathogenic MSH6 P52701 F432N 432 F N 0.768 Pathogenic MSH6 P52701 F432P 432 F P 0.946 Pathogenic MSH6 P52701 F432Q 432 F Q 0.79 Pathogenic MSH6 P52701 F432R 432 F R 0.918 Pathogenic MSH6 P52701 F432S 432 F S 0.876 Pathogenic MSH6 P52701 F432T 432 F T 0.608 Pathogenic MSH6 P52701 F432V 432 F V 0.764 Pathogenic MSH6 P52701 F432W 432 F W 0.874 Pathogenic MSH6 P52701 F432Y 432 F Y 0.588 Pathogenic MSH6 P52701 Y433A 433 Y A 0.438 Neutral MSH6 P52701 Y433C 433 Y C 0.694 Pathogenic MSH6 P52701 Y433D 433 Y D 0.85 Pathogenic MSH6 P52701 Y433E 433 Y E 0.764 Pathogenic MSH6 P52701 Y433F 433 Y F 0.85 Pathogenic MSH6 P52701 Y433G 433 Y G 0.482 Neutral MSH6 P52701 Y433H 433 Y H 0.624 Pathogenic MSH6 P52701 Y433I 433 Y I 0.804 Pathogenic MSH6 P52701 Y433K 433 Y K 0.83 Pathogenic MSH6 P52701 Y433L 433 Y L 0.724 Pathogenic MSH6 P52701 Y433M 433 Y M 0.7 Pathogenic MSH6 P52701 Y433N 433 Y N 0.748 Pathogenic MSH6 P52701 Y433P 433 Y P 0.792 Pathogenic MSH6 P52701 Y433Q 433 Y Q 0.672 Pathogenic MSH6 P52701 Y433R 433 Y R 0.794 Pathogenic MSH6 P52701 Y433S 433 Y S 0.482 Neutral MSH6 P52701 Y433T 433 Y T 0.69 Pathogenic MSH6 P52701 Y433V 433 Y V 0.68 Pathogenic MSH6 P52701 Y433W 433 Y W 0.662 Pathogenic MSH6 P52701 E434A 434 E A 0.81 Pathogenic MSH6 P52701 E434C 434 E C 0.77 Pathogenic MSH6 P52701 E434D 434 E D 0.894 Pathogenic MSH6 P52701 E434F 434 E F 0.96 Pathogenic MSH6 P52701 E434G 434 E G 0.328 Neutral MSH6 P52701 E434H 434 E H 0.76 Pathogenic MSH6 P52701 E434I 434 E I 0.976 Pathogenic MSH6 P52701 E434K 434 E K 0.928 Pathogenic MSH6 P52701 E434L 434 E L 0.972 Pathogenic MSH6 P52701 E434M 434 E M 0.916 Pathogenic MSH6 P52701 E434N 434 E N 0.796 Pathogenic MSH6 P52701 E434P 434 E P 0.936 Pathogenic MSH6 P52701 E434Q 434 E Q 0.866 Pathogenic MSH6 P52701 E434R 434 E R 0.936 Pathogenic MSH6 P52701 E434S 434 E S 0.908 Pathogenic MSH6 P52701 E434T 434 E T 0.852 Pathogenic MSH6 P52701 E434V 434 E V 0.918 Pathogenic MSH6 P52701 E434W 434 E W 0.982 Pathogenic MSH6 P52701 E434Y 434 E Y 0.96 Pathogenic MSH6 P52701 L435A 435 L A 0.714 Pathogenic MSH6 P52701 L435C 435 L C 0.816 Pathogenic MSH6 P52701 L435D 435 L D 0.898 Pathogenic MSH6 P52701 L435E 435 L E 0.88 Pathogenic MSH6 P52701 L435F 435 L F 0.676 Pathogenic MSH6 P52701 L435G 435 L G 0.868 Pathogenic MSH6 P52701 L435H 435 L H 0.906 Pathogenic MSH6 P52701 L435I 435 L I 0.404 Neutral MSH6 P52701 L435K 435 L K 0.706 Pathogenic MSH6 P52701 L435M 435 L M 0.188 Neutral MSH6 P52701 L435N 435 L N 0.808 Pathogenic MSH6 P52701 L435P 435 L P 0.978 Pathogenic MSH6 P52701 L435Q 435 L Q 0.764 Pathogenic MSH6 P52701 L435R 435 L R 0.982 Pathogenic MSH6 P52701 L435S 435 L S 0.696 Pathogenic MSH6 P52701 L435T 435 L T 0.172 Neutral MSH6 P52701 L435V 435 L V 0.386 Neutral MSH6 P52701 L435W 435 L W 0.862 Pathogenic MSH6 P52701 L435Y 435 L Y 0.878 Pathogenic MSH6 P52701 Y436A 436 Y A 0.434 Neutral MSH6 P52701 Y436C 436 Y C 0.684 Pathogenic MSH6 P52701 Y436D 436 Y D 0.836 Pathogenic MSH6 P52701 Y436E 436 Y E 0.736 Pathogenic MSH6 P52701 Y436F 436 Y F 0.168 Neutral MSH6 P52701 Y436G 436 Y G 0.48 Neutral MSH6 P52701 Y436H 436 Y H 0.586 Pathogenic MSH6 P52701 Y436I 436 Y I 0.794 Pathogenic MSH6 P52701 Y436K 436 Y K 0.804 Pathogenic MSH6 P52701 Y436L 436 Y L 0.698 Pathogenic MSH6 P52701 Y436M 436 Y M 0.67 Pathogenic MSH6 P52701 Y436N 436 Y N 0.732 Pathogenic MSH6 P52701 Y436P 436 Y P 0.776 Pathogenic MSH6 P52701 Y436Q 436 Y Q 0.642 Pathogenic MSH6 P52701 Y436R 436 Y R 0.758 Pathogenic MSH6 P52701 Y436S 436 Y S 0.48 Neutral MSH6 P52701 Y436T 436 Y T 0.68 Pathogenic MSH6 P52701 Y436V 436 Y V 0.628 Pathogenic MSH6 P52701 Y436W 436 Y W 0.904 Pathogenic MSH6 P52701 H437A 437 H A 0.712 Pathogenic MSH6 P52701 H437C 437 H C 0.674 Pathogenic MSH6 P52701 H437D 437 H D 0.612 Pathogenic MSH6 P52701 H437E 437 H E 0.166 Neutral MSH6 P52701 H437F 437 H F 0.924 Pathogenic MSH6 P52701 H437G 437 H G 0.52 Pathogenic MSH6 P52701 H437I 437 H I 0.904 Pathogenic MSH6 P52701 H437K 437 H K 0.796 Pathogenic MSH6 P52701 H437L 437 H L 0.826 Pathogenic MSH6 P52701 H437M 437 H M 0.782 Pathogenic MSH6 P52701 H437N 437 H N 0.268 Neutral MSH6 P52701 H437P 437 H P 0.984 Pathogenic MSH6 P52701 H437Q 437 H Q 0.372 Neutral MSH6 P52701 H437R 437 H R 0.9 Pathogenic MSH6 P52701 H437S 437 H S 0.742 Pathogenic MSH6 P52701 H437T 437 H T 0.684 Pathogenic MSH6 P52701 H437V 437 H V 0.722 Pathogenic MSH6 P52701 H437W 437 H W 0.984 Pathogenic MSH6 P52701 H437Y 437 H Y 0.8 Pathogenic MSH6 P52701 M438A 438 M A 0.194 Neutral MSH6 P52701 M438C 438 M C 0.478 Neutral MSH6 P52701 M438D 438 M D 0.184 Neutral MSH6 P52701 M438E 438 M E 0.738 Pathogenic MSH6 P52701 M438F 438 M F 0.872 Pathogenic MSH6 P52701 M438G 438 M G 0.15 Neutral MSH6 P52701 M438H 438 M H 0.832 Pathogenic MSH6 P52701 M438I 438 M I 0.478 Neutral MSH6 P52701 M438K 438 M K 0.248 Neutral MSH6 P52701 M438L 438 M L 0.742 Pathogenic MSH6 P52701 M438N 438 M N 0.162 Neutral MSH6 P52701 M438P 438 M P 0.932 Pathogenic MSH6 P52701 M438Q 438 M Q 0.674 Pathogenic MSH6 P52701 M438R 438 M R 0.56 Pathogenic MSH6 P52701 M438S 438 M S 0.194 Neutral MSH6 P52701 M438T 438 M T 0.366 Neutral MSH6 P52701 M438V 438 M V 0.326 Neutral MSH6 P52701 M438W 438 M W 0.77 Pathogenic MSH6 P52701 M438Y 438 M Y 0.976 Pathogenic MSH6 P52701 D439A 439 D A 0.792 Pathogenic MSH6 P52701 D439C 439 D C 0.886 Pathogenic MSH6 P52701 D439E 439 D E 0.82 Pathogenic MSH6 P52701 D439F 439 D F 0.976 Pathogenic MSH6 P52701 D439G 439 D G 0.948 Pathogenic MSH6 P52701 D439H 439 D H 0.638 Pathogenic MSH6 P52701 D439I 439 D I 0.968 Pathogenic MSH6 P52701 D439K 439 D K 0.928 Pathogenic MSH6 P52701 D439L 439 D L 0.974 Pathogenic MSH6 P52701 D439M 439 D M 0.954 Pathogenic MSH6 P52701 D439N 439 D N 0.864 Pathogenic MSH6 P52701 D439P 439 D P 0.904 Pathogenic MSH6 P52701 D439Q 439 D Q 0.636 Pathogenic MSH6 P52701 D439R 439 D R 0.958 Pathogenic MSH6 P52701 D439S 439 D S 0.586 Pathogenic MSH6 P52701 D439T 439 D T 0.806 Pathogenic MSH6 P52701 D439V 439 D V 0.988 Pathogenic MSH6 P52701 D439W 439 D W 0.982 Pathogenic MSH6 P52701 D439Y 439 D Y 0.976 Pathogenic MSH6 P52701 P44A 44 P A 0.052 Neutral MSH6 P52701 P44C 44 P C 0.148 Neutral MSH6 P52701 P44D 44 P D 0.078 Neutral MSH6 P52701 P44E 44 P E 0.052 Neutral MSH6 P52701 P44F 44 P F 0.272 Neutral MSH6 P52701 P44G 44 P G 0.07 Neutral MSH6 P52701 P44H 44 P H 0.266 Neutral MSH6 P52701 P44I 44 P I 0.104 Neutral MSH6 P52701 P44K 44 P K 0.206 Neutral MSH6 P52701 P44L 44 P L 0.094 Neutral MSH6 P52701 P44M 44 P M 0.22 Neutral MSH6 P52701 P44N 44 P N 0.004 Neutral MSH6 P52701 P44Q 44 P Q 0.212 Neutral MSH6 P52701 P44R 44 P R 0.206 Neutral MSH6 P52701 P44S 44 P S 0.002 Neutral MSH6 P52701 P44T 44 P T 0.122 Neutral MSH6 P52701 P44V 44 P V 0.14 Neutral MSH6 P52701 P44W 44 P W 0.39 Neutral MSH6 P52701 P44Y 44 P Y 0.32 Neutral MSH6 P52701 A440C 440 A C 0.862 Pathogenic MSH6 P52701 A440D 440 A D 0.922 Pathogenic MSH6 P52701 A440E 440 A E 0.876 Pathogenic MSH6 P52701 A440F 440 A F 0.966 Pathogenic MSH6 P52701 A440G 440 A G 0.734 Pathogenic MSH6 P52701 A440H 440 A H 0.866 Pathogenic MSH6 P52701 A440I 440 A I 0.958 Pathogenic MSH6 P52701 A440K 440 A K 0.936 Pathogenic MSH6 P52701 A440L 440 A L 0.98 Pathogenic MSH6 P52701 A440M 440 A M 0.854 Pathogenic MSH6 P52701 A440N 440 A N 0.854 Pathogenic MSH6 P52701 A440P 440 A P 0.958 Pathogenic MSH6 P52701 A440Q 440 A Q 0.814 Pathogenic MSH6 P52701 A440R 440 A R 0.954 Pathogenic MSH6 P52701 A440S 440 A S 0.394 Neutral MSH6 P52701 A440T 440 A T 0.734 Pathogenic MSH6 P52701 A440V 440 A V 0.908 Pathogenic MSH6 P52701 A440W 440 A W 0.976 Pathogenic MSH6 P52701 A440Y 440 A Y 0.962 Pathogenic MSH6 P52701 L441A 441 L A 0.046 Neutral MSH6 P52701 L441C 441 L C 0.358 Neutral MSH6 P52701 L441D 441 L D 0.086 Neutral MSH6 P52701 L441E 441 L E 0.074 Neutral MSH6 P52701 L441F 441 L F 0.81 Pathogenic MSH6 P52701 L441G 441 L G 0.568 Pathogenic MSH6 P52701 L441H 441 L H 0.028 Neutral MSH6 P52701 L441I 441 L I 0.12 Neutral MSH6 P52701 L441K 441 L K 0.474 Neutral MSH6 P52701 L441M 441 L M 0.07 Neutral MSH6 P52701 L441N 441 L N 0.596 Pathogenic MSH6 P52701 L441P 441 L P 0.952 Pathogenic MSH6 P52701 L441Q 441 L Q 0.324 Neutral MSH6 P52701 L441R 441 L R 0.766 Pathogenic MSH6 P52701 L441S 441 L S 0.092 Neutral MSH6 P52701 L441T 441 L T 0.038 Neutral MSH6 P52701 L441V 441 L V 0.046 Neutral MSH6 P52701 L441W 441 L W 0.866 Pathogenic MSH6 P52701 L441Y 441 L Y 0.862 Pathogenic MSH6 P52701 I442A 442 I A 0.162 Neutral MSH6 P52701 I442C 442 I C 0.602 Pathogenic MSH6 P52701 I442D 442 I D 0.744 Pathogenic MSH6 P52701 I442E 442 I E 0.184 Neutral MSH6 P52701 I442F 442 I F 0.962 Pathogenic MSH6 P52701 I442G 442 I G 0.794 Pathogenic MSH6 P52701 I442H 442 I H 0.848 Pathogenic MSH6 P52701 I442K 442 I K 0.846 Pathogenic MSH6 P52701 I442L 442 I L 0.714 Pathogenic MSH6 P52701 I442M 442 I M 0.688 Pathogenic MSH6 P52701 I442N 442 I N 0.77 Pathogenic MSH6 P52701 I442P 442 I P 0.926 Pathogenic MSH6 P52701 I442Q 442 I Q 0.784 Pathogenic MSH6 P52701 I442R 442 I R 0.874 Pathogenic MSH6 P52701 I442S 442 I S 0.61 Pathogenic MSH6 P52701 I442T 442 I T 0.082 Neutral MSH6 P52701 I442V 442 I V 0.164 Neutral MSH6 P52701 I442W 442 I W 0.986 Pathogenic MSH6 P52701 I442Y 442 I Y 0.976 Pathogenic MSH6 P52701 G443A 443 G A 0.316 Neutral MSH6 P52701 G443C 443 G C 0.77 Pathogenic MSH6 P52701 G443D 443 G D 0.998 Pathogenic MSH6 P52701 G443E 443 G E 0.982 Pathogenic MSH6 P52701 G443F 443 G F 0.976 Pathogenic MSH6 P52701 G443H 443 G H 0.98 Pathogenic MSH6 P52701 G443I 443 G I 0.91 Pathogenic MSH6 P52701 G443K 443 G K 0.98 Pathogenic MSH6 P52701 G443L 443 G L 0.978 Pathogenic MSH6 P52701 G443M 443 G M 0.994 Pathogenic MSH6 P52701 G443N 443 G N 0.984 Pathogenic MSH6 P52701 G443P 443 G P 0.938 Pathogenic MSH6 P52701 G443Q 443 G Q 0.986 Pathogenic MSH6 P52701 G443R 443 G R 1 Pathogenic MSH6 P52701 G443S 443 G S 0.438 Neutral MSH6 P52701 G443T 443 G T 0.724 Pathogenic MSH6 P52701 G443V 443 G V 0.704 Pathogenic MSH6 P52701 G443W 443 G W 0.972 Pathogenic MSH6 P52701 G443Y 443 G Y 0.934 Pathogenic MSH6 P52701 V444A 444 V A 0.068 Neutral MSH6 P52701 V444C 444 V C 0.724 Pathogenic MSH6 P52701 V444D 444 V D 0.872 Pathogenic MSH6 P52701 V444E 444 V E 0.982 Pathogenic MSH6 P52701 V444F 444 V F 0.53 Pathogenic MSH6 P52701 V444G 444 V G 0.904 Pathogenic MSH6 P52701 V444H 444 V H 0.256 Neutral MSH6 P52701 V444I 444 V I 0.45 Neutral MSH6 P52701 V444K 444 V K 0.984 Pathogenic MSH6 P52701 V444L 444 V L 0.834 Pathogenic MSH6 P52701 V444M 444 V M 0.418 Neutral MSH6 P52701 V444N 444 V N 0.548 Pathogenic MSH6 P52701 V444P 444 V P 0.978 Pathogenic MSH6 P52701 V444Q 444 V Q 0.602 Pathogenic MSH6 P52701 V444R 444 V R 0.96 Pathogenic MSH6 P52701 V444S 444 V S 0.746 Pathogenic MSH6 P52701 V444T 444 V T 0.138 Neutral MSH6 P52701 V444W 444 V W 0.904 Pathogenic MSH6 P52701 V444Y 444 V Y 0.93 Pathogenic MSH6 P52701 S445A 445 S A 0.124 Neutral MSH6 P52701 S445C 445 S C 0.522 Pathogenic MSH6 P52701 S445D 445 S D 0.56 Pathogenic MSH6 P52701 S445E 445 S E 0.46 Neutral MSH6 P52701 S445F 445 S F 0.892 Pathogenic MSH6 P52701 S445G 445 S G 0.4 Neutral MSH6 P52701 S445H 445 S H 0.82 Pathogenic MSH6 P52701 S445I 445 S I 0.634 Pathogenic MSH6 P52701 S445K 445 S K 0.458 Neutral MSH6 P52701 S445L 445 S L 0.652 Pathogenic MSH6 P52701 S445M 445 S M 0.976 Pathogenic MSH6 P52701 S445N 445 S N 0.05 Neutral MSH6 P52701 S445P 445 S P 0.67 Pathogenic MSH6 P52701 S445Q 445 S Q 0.48 Neutral MSH6 P52701 S445R 445 S R 0.492 Neutral MSH6 P52701 S445T 445 S T 0.06 Neutral MSH6 P52701 S445V 445 S V 0.816 Pathogenic MSH6 P52701 S445W 445 S W 0.946 Pathogenic MSH6 P52701 S445Y 445 S Y 0.93 Pathogenic MSH6 P52701 E446A 446 E A 0.25 Neutral MSH6 P52701 E446C 446 E C 0.3 Neutral MSH6 P52701 E446D 446 E D 0.136 Neutral MSH6 P52701 E446F 446 E F 0.93 Pathogenic MSH6 P52701 E446G 446 E G 0.344 Neutral MSH6 P52701 E446H 446 E H 0.304 Neutral MSH6 P52701 E446I 446 E I 0.46 Neutral MSH6 P52701 E446K 446 E K 0.306 Neutral MSH6 P52701 E446L 446 E L 0.324 Neutral MSH6 P52701 E446M 446 E M 0.64 Pathogenic MSH6 P52701 E446N 446 E N 0.074 Neutral MSH6 P52701 E446P 446 E P 0.91 Pathogenic MSH6 P52701 E446Q 446 E Q 0.088 Neutral MSH6 P52701 E446R 446 E R 0.812 Pathogenic MSH6 P52701 E446S 446 E S 0.76 Pathogenic MSH6 P52701 E446T 446 E T 0.776 Pathogenic MSH6 P52701 E446V 446 E V 0.324 Neutral MSH6 P52701 E446W 446 E W 0.976 Pathogenic MSH6 P52701 E446Y 446 E Y 0.906 Pathogenic MSH6 P52701 L447A 447 L A 0.704 Pathogenic MSH6 P52701 L447C 447 L C 0.216 Neutral MSH6 P52701 L447D 447 L D 0.888 Pathogenic MSH6 P52701 L447E 447 L E 0.868 Pathogenic MSH6 P52701 L447F 447 L F 0.416 Neutral MSH6 P52701 L447G 447 L G 0.826 Pathogenic MSH6 P52701 L447H 447 L H 0.908 Pathogenic MSH6 P52701 L447I 447 L I 0.518 Pathogenic MSH6 P52701 L447K 447 L K 0.724 Pathogenic MSH6 P52701 L447M 447 L M 0.358 Neutral MSH6 P52701 L447N 447 L N 0.764 Pathogenic MSH6 P52701 L447P 447 L P 0.994 Pathogenic MSH6 P52701 L447Q 447 L Q 0.732 Pathogenic MSH6 P52701 L447R 447 L R 0.978 Pathogenic MSH6 P52701 L447S 447 L S 0.642 Pathogenic MSH6 P52701 L447T 447 L T 0.6 Pathogenic MSH6 P52701 L447V 447 L V 0.472 Neutral MSH6 P52701 L447W 447 L W 0.892 Pathogenic MSH6 P52701 L447Y 447 L Y 0.88 Pathogenic MSH6 P52701 G448A 448 G A 0.542 Pathogenic MSH6 P52701 G448C 448 G C 0.88 Pathogenic MSH6 P52701 G448D 448 G D 0.492 Neutral MSH6 P52701 G448E 448 G E 0.612 Pathogenic MSH6 P52701 G448F 448 G F 0.958 Pathogenic MSH6 P52701 G448H 448 G H 0.69 Pathogenic MSH6 P52701 G448I 448 G I 0.948 Pathogenic MSH6 P52701 G448K 448 G K 0.682 Pathogenic MSH6 P52701 G448L 448 G L 0.958 Pathogenic MSH6 P52701 G448M 448 G M 0.968 Pathogenic MSH6 P52701 G448N 448 G N 0.494 Neutral MSH6 P52701 G448P 448 G P 0.92 Pathogenic MSH6 P52701 G448Q 448 G Q 0.71 Pathogenic MSH6 P52701 G448R 448 G R 0.98 Pathogenic MSH6 P52701 G448S 448 G S 0.27 Neutral MSH6 P52701 G448T 448 G T 0.778 Pathogenic MSH6 P52701 G448V 448 G V 0.954 Pathogenic MSH6 P52701 G448W 448 G W 0.94 Pathogenic MSH6 P52701 G448Y 448 G Y 0.928 Pathogenic MSH6 P52701 L449A 449 L A 0.706 Pathogenic MSH6 P52701 L449C 449 L C 0.81 Pathogenic MSH6 P52701 L449D 449 L D 0.88 Pathogenic MSH6 P52701 L449E 449 L E 0.86 Pathogenic MSH6 P52701 L449F 449 L F 0.422 Neutral MSH6 P52701 L449G 449 L G 0.844 Pathogenic MSH6 P52701 L449H 449 L H 0.904 Pathogenic MSH6 P52701 L449I 449 L I 0.26 Neutral MSH6 P52701 L449K 449 L K 0.696 Pathogenic MSH6 P52701 L449M 449 L M 0.32 Neutral MSH6 P52701 L449N 449 L N 0.778 Pathogenic MSH6 P52701 L449P 449 L P 0.97 Pathogenic 5 MSH6 P52701 L449Q 449 L Q 0.742 Pathogenic MSH6 P52701 L449R 449 L R 0.974 Pathogenic MSH6 P52701 L449S 449 L S 0.658 Pathogenic MSH6 P52701 L449T 449 L T 0.586 Pathogenic MSH6 P52701 L449V 449 L V 0.064 Neutral MSH6 P52701 L449W 449 L W 0.836 Pathogenic MSH6 P52701 L449Y 449 L Y 0.86 Pathogenic MSH6 P52701 G45A 45 G A 0.01 Neutral MSH6 P52701 G45C 45 G C 0.14 Neutral MSH6 P52701 G45D 45 G D 0.244 Neutral MSH6 P52701 G45E 45 G E 0.304 Neutral MSH6 P52701 G45F 45 G F 0.498 Neutral MSH6 P52701 G45H 45 G H 0.442 Neutral MSH6 P52701 G45I 45 G I 0.412 Neutral MSH6 P52701 G45K 45 G K 0.358 Neutral MSH6 P52701 G45L 45 G L 0.412 Neutral MSH6 P52701 G45M 45 G M 0.422 Neutral MSH6 P52701 G45N 45 G N 0.172 Neutral MSH6 P52701 G45P 45 G P 0.402 Neutral MSH6 P52701 G45Q 45 G Q 0.262 Neutral MSH6 P52701 G45R 45 G R 0.362 Neutral MSH6 P52701 G45S 45 G S 0.018 Neutral MSH6 P52701 G45T 45 G T 0.25 Neutral MSH6 P52701 G45V 45 G V 0.394 Neutral MSH6 P52701 G45W 45 G W 0.498 Neutral MSH6 P52701 G45Y 45 G Y 0.5 Pathogenic MSH6 P52701 V450A 450 V A 0.042 Neutral MSH6 P52701 V450C 450 V C 0.342 Neutral MSH6 P52701 V450D 450 V D 0.546 Pathogenic MSH6 P52701 V450E 450 V E 0.554 Pathogenic MSH6 P52701 V450F 450 V F 0.744 Pathogenic MSH6 P52701 V450G 450 V G 0.528 Pathogenic MSH6 P52701 V450H 450 V H 0.506 Pathogenic MSH6 P52701 V450I 450 V I 0.074 Neutral MSH6 P52701 V450K 450 V K 0.182 Neutral MSH6 P52701 V450L 450 V L 0.092 Neutral MSH6 P52701 V450M 450 V M 0.452 Neutral MSH6 P52701 V450N 450 V N 0.094 Neutral MSH6 P52701 V450P 450 V P 0.816 Pathogenic MSH6 P52701 V450Q 450 V Q 0.124 Neutral MSH6 P52701 V450R 450 V R 0.774 Pathogenic MSH6 P52701 V450S 450 V S 0.06 Neutral MSH6 P52701 V450T 450 V T 0.042 Neutral MSH6 P52701 V450W 450 V W 0.822 Pathogenic MSH6 P52701 V450Y 450 V Y 0.814 Pathogenic MSH6 P52701 F451A 451 F A 0.422 Neutral MSH6 P52701 F451C 451 F C 0.584 Pathogenic MSH6 P52701 F451D 451 F D 0.812 Pathogenic MSH6 P52701 F451E 451 F E 0.892 Pathogenic MSH6 P52701 F451G 451 F G 0.49 Neutral MSH6 P52701 F451H 451 F H 0.648 Pathogenic MSH6 P52701 F451I 451 F I 0.562 Pathogenic MSH6 P52701 F451K 451 F K 0.862 Pathogenic MSH6 P52701 F451L 451 F L 0.072 Neutral MSH6 P52701 F451M 451 F M 0.09 Neutral MSH6 P52701 F451N 451 F N 0.73 Pathogenic MSH6 P52701 F451P 451 F P 0.928 Pathogenic MSH6 P52701 F451Q 451 F Q 0.762 Pathogenic MSH6 P52701 F451R 451 F R 0.93 Pathogenic MSH6 P52701 F451S 451 F S 0.744 Pathogenic MSH6 P52701 F451T 451 F T 0.574 Pathogenic MSH6 P52701 F451V 451 F V 0.802 Pathogenic MSH6 P52701 F451W 451 F W 0.824 Pathogenic MSH6 P52701 F451Y 451 F Y 0.286 Neutral MSH6 P52701 M452A 452 M A 0.286 Neutral MSH6 P52701 M452C 452 M C 0.626 Pathogenic MSH6 P52701 M452D 452 M D 0.874 Pathogenic MSH6 P52701 M452E 452 M E 0.818 Pathogenic MSH6 P52701 M452F 452 M F 0.796 Pathogenic MSH6 P52701 M452G 452 M G 0.546 Pathogenic MSH6 P52701 M452H 452 M H 0.94 Pathogenic MSH6 P52701 M452I 452 M I 0.84 Pathogenic MSH6 P52701 M452K 452 M K 0.962 Pathogenic MSH6 P52701 M452L 452 M L 0.478 Neutral MSH6 P52701 M452N 452 M N 0.908 Pathogenic MSH6 P52701 M452P 452 M P 0.93 Pathogenic MSH6 P52701 M452Q 452 M Q 0.79 Pathogenic MSH6 P52701 M452R 452 M R 0.946 Pathogenic MSH6 P52701 M452S 452 M S 0.41 Neutral MSH6 P52701 M452T 452 M T 0.12 Neutral MSH6 P52701 M452V 452 M V 0.612 Pathogenic MSH6 P52701 M452W 452 M W 0.95 Pathogenic MSH6 P52701 M452Y 452 M Y 0.964 Pathogenic MSH6 P52701 K453A 453 K A 0.158 Neutral MSH6 P52701 K453C 453 K C 0.434 Neutral MSH6 P52701 K453D 453 K D 0.054 Neutral MSH6 P52701 K453E 453 K E 0.728 Pathogenic MSH6 P52701 K453F 453 K F 0.966 Pathogenic MSH6 P52701 K453G 453 K G 0.296 Neutral MSH6 P52701 K453H 453 K H 0.75 Pathogenic MSH6 P52701 K453I 453 K I 0.984 Pathogenic MSH6 P52701 K453L 453 K L 0.974 Pathogenic MSH6 P52701 K453M 453 K M 0.916 Pathogenic MSH6 P52701 K453N 453 K N 0.658 Pathogenic MSH6 P52701 K453P 453 K P 0.918 Pathogenic MSH6 P52701 K453Q 453 K Q 0.296 Neutral MSH6 P52701 K453R 453 K R 0.138 Neutral MSH6 P52701 K453S 453 K S 0.356 Neutral MSH6 P52701 K453T 453 K T 0.616 Pathogenic MSH6 P52701 K453V 453 K V 0.876 Pathogenic MSH6 P52701 K453W 453 K W 0.992 Pathogenic MSH6 P52701 K453Y 453 K Y 0.986 Pathogenic MSH6 P52701 G454A 454 G A 0.596 Pathogenic MSH6 P52701 G454C 454 G C 0.922 Pathogenic MSH6 P52701 G454D 454 G D 0.96 Pathogenic MSH6 P52701 G454E 454 G E 0.982 Pathogenic MSH6 P52701 G454F 454 G F 0.988 Pathogenic MSH6 P52701 G454H 454 G H 0.992 Pathogenic MSH6 P52701 G454I 454 G I 0.926 Pathogenic MSH6 P52701 G454K 454 G K 0.992 Pathogenic MSH6 P52701 G454L 454 G L 0.988 Pathogenic MSH6 P52701 G454M 454 G M 0.994 Pathogenic MSH6 P52701 G454N 454 G N 0.922 Pathogenic MSH6 P52701 G454P 454 G P 0.932 Pathogenic MSH6 P52701 G454Q 454 G Q 0.968 Pathogenic MSH6 P52701 G454R 454 G R 0.642 Pathogenic MSH6 P52701 G454S 454 G S 0.646 Pathogenic MSH6 P52701 G454T 454 G T 0.918 Pathogenic MSH6 P52701 G454V 454 G V 0.912 Pathogenic MSH6 P52701 G454W 454 G W 0.984 Pathogenic MSH6 P52701 G454Y 454 G Y 0.986 Pathogenic MSH6 P52701 N455A 455 N A 0.07 Neutral MSH6 P52701 N455C 455 N C 0.544 Pathogenic MSH6 P52701 N455D 455 N D 0.022 Neutral MSH6 P52701 N455E 455 N E 0.03 Neutral MSH6 P52701 N455F 455 N F 0.892 Pathogenic MSH6 P52701 N455G 455 N G 0.334 Neutral MSH6 P52701 N455H 455 N H 0.732 Pathogenic MSH6 P52701 N455I 455 N I 0.4 Neutral MSH6 P52701 N455K 455 N K 0.08 Neutral MSH6 P52701 N455L 455 N L 0.796 Pathogenic MSH6 P52701 N455M 455 N M 0.762 Pathogenic MSH6 P52701 N455P 455 N P 0.702 Pathogenic MSH6 P52701 N455Q 455 N Q 0.548 Pathogenic MSH6 P52701 N455R 455 N R 0.618 Pathogenic MSH6 P52701 N455S 455 N S 0.02 Neutral MSH6 P52701 N455T 455 N T 0.02 Neutral MSH6 P52701 N455V 455 N V 0.078 Neutral MSH6 P52701 N455W 455 N W 0.916 Pathogenic MSH6 P52701 N455Y 455 N Y 0.894 Pathogenic MSH6 P52701 W456A 456 W A 0.326 Neutral MSH6 P52701 W456C 456 W C 0.252 Neutral MSH6 P52701 W456D 456 W D 0.416 Neutral MSH6 P52701 W456E 456 W E 0.5 Pathogenic MSH6 P52701 W456F 456 W F 0.042 Neutral MSH6 P52701 W456G 456 W G 0.36 Neutral MSH6 P52701 W456H 456 W H 0.278 Neutral MSH6 P52701 W456I 456 W I 0.426 Neutral MSH6 P52701 W456K 456 W K 0.108 Neutral MSH6 P52701 W456L 456 W L 0.216 Neutral MSH6 P52701 W456M 456 W M 0.246 Neutral MSH6 P52701 W456N 456 W N 0.172 Neutral MSH6 P52701 W456P 456 W P 0.328 Neutral MSH6 P52701 W456Q 456 W Q 0.196 Neutral MSH6 P52701 W456R 456 W R 0.496 Neutral MSH6 P52701 W456S 456 W S 0.34 Neutral MSH6 P52701 W456T 456 W T 0.326 Neutral MSH6 P52701 W456V 456 W V 0.356 Neutral MSH6 P52701 W456Y 456 W Y 0.012 Neutral MSH6 P52701 A457C 457 A C 0.978 Pathogenic MSH6 P52701 A457D 457 A D 0.956 Pathogenic MSH6 P52701 A457E 457 A E 0.984 Pathogenic MSH6 P52701 A457F 457 A F 0.88 Pathogenic MSH6 P52701 A457G 457 A G 0.364 Neutral MSH6 P52701 A457H 457 A H 0.942 Pathogenic MSH6 P52701 A457I 457 A I 0.922 Pathogenic MSH6 P52701 A457K 457 A K 0.664 Pathogenic MSH6 P52701 A457L 457 A L 0.804 Pathogenic MSH6 P52701 A457M 457 A M 0.908 Pathogenic MSH6 P52701 A457N 457 A N 0.88 Pathogenic MSH6 P52701 A457P 457 A P 0.4 Neutral MSH6 P52701 A457Q 457 A Q 0.906 Pathogenic MSH6 P52701 A457R 457 A R 0.592 Pathogenic MSH6 P52701 A457S 457 A S 0.366 Neutral MSH6 P52701 A457T 457 A T 0.924 Pathogenic MSH6 P52701 A457V 457 A V 0.926 Pathogenic MSH6 P52701 A457W 457 A W 0.996 Pathogenic MSH6 P52701 A457Y 457 A Y 0.966 Pathogenic MSH6 P52701 H458A 458 H A 0.716 Pathogenic MSH6 P52701 H458C 458 H C 0.682 Pathogenic MSH6 P52701 H458D 458 H D 0.608 Pathogenic MSH6 P52701 H458E 458 H E 0.804 Pathogenic MSH6 P52701 H458F 458 H F 0.884 Pathogenic MSH6 P52701 H458G 458 H G 0.522 Pathogenic MSH6 P52701 H458I 458 H I 0.872 Pathogenic MSH6 P52701 H458K 458 H K 0.658 Pathogenic MSH6 P52701 H458L 458 H L 0.696 Pathogenic MSH6 P52701 H458M 458 H M 0.152 Neutral MSH6 P52701 H458N 458 H N 0.616 Pathogenic MSH6 P52701 H458P 458 H P 0.98 Pathogenic MSH6 P52701 H458Q 458 H Q 0.82 Pathogenic MSH6 P52701 H458R 458 H R 0.9 Pathogenic MSH6 P52701 H458S 458 H S 0.31 Neutral MSH6 P52701 H458T 458 H T 0.196 Neutral MSH6 P52701 H458V 458 H V 0.672 Pathogenic MSH6 P52701 H458W 458 H W 0.942 Pathogenic MSH6 P52701 H458Y 458 H Y 0.9 Pathogenic MSH6 P52701 S459A 459 S A 0.148 Neutral MSH6 P52701 S459C 459 S C 0.244 Neutral MSH6 P52701 S459D 459 S D 0.794 Pathogenic MSH6 P52701 S459E 459 S E 0.906 Pathogenic MSH6 P52701 S459F 459 S F 0.836 Pathogenic MSH6 P52701 S459G 459 S G 0.532 Pathogenic MSH6 P52701 S459H 459 S H 0.92 Pathogenic MSH6 P52701 S459I 459 S I 0.772 Pathogenic MSH6 P52701 S459K 459 S K 0.894 Pathogenic MSH6 P52701 S459L 459 S L 0.874 Pathogenic MSH6 P52701 S459M 459 S M 0.994 Pathogenic MSH6 P52701 S459N 459 S N 0.742 Pathogenic MSH6 P52701 S459P 459 S P 0.908 Pathogenic MSH6 P52701 S459Q 459 S Q 0.86 Pathogenic MSH6 P52701 S459R 459 S R 0.928 Pathogenic MSH6 P52701 S459T 459 S T 0.812 Pathogenic MSH6 P52701 S459V 459 S V 0.338 Neutral MSH6 P52701 S459W 459 S W 0.968 Pathogenic MSH6 P52701 S459Y 459 S Y 0.966 Pathogenic MSH6 P52701 G46A 46 G A 0.008 Neutral MSH6 P52701 G46C 46 G C 0.14 Neutral MSH6 P52701 G46D 46 G D 0.12 Neutral MSH6 P52701 G46E 46 G E 0.19 Neutral MSH6 P52701 G46F 46 G F 0.498 Neutral MSH6 P52701 G46H 46 G H 0.442 Neutral MSH6 P52701 G46I 46 G I 0.412 Neutral MSH6 P52701 G46K 46 G K 0.358 Neutral MSH6 P52701 G46L 46 G L 0.412 Neutral MSH6 P52701 G46M 46 G M 0.422 Neutral MSH6 P52701 G46N 46 G N 0.168 Neutral MSH6 P52701 G46P 46 G P 0.442 Neutral MSH6 P52701 G46Q 46 G Q 0.262 Neutral MSH6 P52701 G46R 46 G R 0.468 Neutral MSH6 P52701 G46S 46 G S 0.018 Neutral MSH6 P52701 G46T 46 G T 0.272 Neutral MSH6 P52701 G46V 46 G V 0.39 Neutral MSH6 P52701 G46W 46 G W 0.498 Neutral MSH6 P52701 G46Y 46 G Y 0.5 Pathogenic MSH6 P52701 G460A 460 G A 0.966 Pathogenic MSH6 P52701 G460C 460 G C 0.948 Pathogenic MSH6 P52701 G460D 460 G D 1 Pathogenic MSH6 P52701 G460E 460 G E 0.988 Pathogenic MSH6 P52701 G460F 460 G F 0.984 Pathogenic MSH6 P52701 G460H 460 G H 0.988 Pathogenic MSH6 P52701 G460I 460 G I 0.974 Pathogenic MSH6 P52701 G460K 460 G K 0.988 Pathogenic MSH6 P52701 G460L 460 G L 0.984 Pathogenic MSH6 P52701 G460M 460 G M 0.94 Pathogenic MSH6 P52701 G460N 460 G N 0.986 Pathogenic MSH6 P52701 G460P 460 G P 0.966 Pathogenic MSH6 P52701 G460Q 460 G Q 0.994 Pathogenic MSH6 P52701 G460R 460 G R 1 Pathogenic MSH6 P52701 G460S 460 G S 0.832 Pathogenic MSH6 P52701 G460T 460 G T 0.846 Pathogenic MSH6 P52701 G460V 460 G V 0.986 Pathogenic MSH6 P52701 G460W 460 G W 0.98 Pathogenic MSH6 P52701 G460Y 460 G Y 0.96 Pathogenic MSH6 P52701 F461A 461 F A 0.51 Pathogenic MSH6 P52701 F461C 461 F C 0.718 Pathogenic MSH6 P52701 F461D 461 F D 0.8 Pathogenic MSH6 P52701 F461E 461 F E 0.848 Pathogenic MSH6 P52701 F461G 461 F G 0.494 Neutral MSH6 P52701 F461H 461 F H 0.76 Pathogenic MSH6 P52701 F461I 461 F I 0.194 Neutral MSH6 P52701 F461K 461 F K 0.836 Pathogenic MSH6 P52701 F461L 461 F L 0.694 Pathogenic MSH6 P52701 F461M 461 F M 0.78 Pathogenic MSH6 P52701 F461N 461 F N 0.434 Neutral MSH6 P52701 F461P 461 F P 0.966 Pathogenic MSH6 P52701 F461Q 461 F Q 0.732 Pathogenic MSH6 P52701 F461R 461 F R 0.902 Pathogenic MSH6 P52701 F461S 461 F S 0.426 Neutral MSH6 P52701 F461T 461 F T 0.572 Pathogenic MSH6 P52701 F461V 461 F V 0.15 Neutral MSH6 P52701 F461W 461 F W 0.884 Pathogenic MSH6 P52701 F461Y 461 F Y 0.61 Pathogenic MSH6 P52701 P462A 462 P A 0.844 Pathogenic MSH6 P52701 P462C 462 P C 0.922 Pathogenic MSH6 P52701 P462D 462 P D 0.874 Pathogenic MSH6 P52701 P462E 462 P E 0.956 Pathogenic MSH6 P52701 P462F 462 P F 0.912 Pathogenic MSH6 P52701 P462G 462 P G 0.698 Pathogenic MSH6 P52701 P462H 462 P H 0.976 Pathogenic MSH6 P52701 P462I 462 P I 0.938 Pathogenic MSH6 P52701 P462K 462 P K 0.946 Pathogenic MSH6 P52701 P462L 462 P L 0.998 Pathogenic MSH6 P52701 P462M 462 P M 0.956 Pathogenic MSH6 P52701 P462N 462 P N 0.796 Pathogenic MSH6 P52701 P462Q 462 P Q 0.878 Pathogenic MSH6 P52701 P462R 462 P R 0.984 Pathogenic MSH6 P52701 P462S 462 P S 0.372 Neutral MSH6 P52701 P462T 462 P T 0.76 Pathogenic MSH6 P52701 P462V 462 P V 0.852 Pathogenic MSH6 P52701 P462W 462 P W 0.936 Pathogenic MSH6 P52701 P462Y 462 P Y 0.932 Pathogenic MSH6 P52701 E463A 463 E A 0.812 Pathogenic MSH6 P52701 E463C 463 E C 0.77 Pathogenic MSH6 P52701 E463D 463 E D 0.894 Pathogenic MSH6 P52701 E463F 463 E F 0.92 Pathogenic MSH6 P52701 E463G 463 E G 0.342 Neutral MSH6 P52701 E463H 463 E H 0.76 Pathogenic MSH6 P52701 E463I 463 E I 0.98 Pathogenic MSH6 P52701 E463K 463 E K 0.928 Pathogenic MSH6 P52701 E463L 463 E L 0.976 Pathogenic MSH6 P52701 E463M 463 E M 0.92 Pathogenic MSH6 P52701 E463N 463 E N 0.8 Pathogenic MSH6 P52701 E463P 463 E P 0.944 Pathogenic MSH6 P52701 E463Q 463 E Q 0.87 Pathogenic MSH6 P52701 E463R 463 E R 0.936 Pathogenic MSH6 P52701 E463S 463 E S 0.916 Pathogenic MSH6 P52701 E463T 463 E T 0.86 Pathogenic MSH6 P52701 E463V 463 E V 0.926 Pathogenic MSH6 P52701 E463W 463 E W 0.982 Pathogenic MSH6 P52701 E463Y 463 E Y 0.96 Pathogenic MSH6 P52701 I464A 464 I A 0.058 Neutral MSH6 P52701 I464C 464 I C 0.386 Neutral MSH6 P52701 I464D 464 I D 0.572 Pathogenic MSH6 P52701 I464E 464 I E 0.554 Pathogenic MSH6 P52701 I464F 464 I F 0.686 Pathogenic MSH6 P52701 I464G 464 I G 0.19 Neutral MSH6 P52701 I464H 464 I H 0.066 Neutral MSH6 P52701 I464K 464 I K 0.082 Neutral MSH6 P52701 I464L 464 I L 0.486 Neutral MSH6 P52701 I464M 464 I M 0.048 Neutral MSH6 P52701 I464N 464 I N 0.65 Pathogenic MSH6 P52701 I464P 464 I P 0.202 Neutral MSH6 P52701 I464Q 464 I Q 0.304 Neutral MSH6 P52701 I464R 464 I R 0.554 Pathogenic MSH6 P52701 I464S 464 I S 0.106 Neutral MSH6 P52701 I464T 464 I T 0.038 Neutral MSH6 P52701 I464V 464 I V 0.016 Neutral MSH6 P52701 I464W 464 I W 0.898 Pathogenic MSH6 P52701 I464Y 464 I Y 0.904 Pathogenic MSH6 P52701 A465C 465 A C 0.948 Pathogenic MSH6 P52701 A465D 465 A D 0.936 Pathogenic MSH6 P52701 A465E 465 A E 0.964 Pathogenic MSH6 P52701 A465F 465 A F 0.99 Pathogenic MSH6 P52701 A465G 465 A G 0.098 Neutral MSH6 P52701 A465H 465 A H 0.924 Pathogenic MSH6 P52701 A465I 465 A I 0.92 Pathogenic MSH6 P52701 A465K 465 A K 0.962 Pathogenic MSH6 P52701 A465L 465 A L 0.994 Pathogenic MSH6 P52701 A465M 465 A M 0.89 Pathogenic MSH6 P52701 A465N 465 A N 0.542 Pathogenic MSH6 P52701 A465P 465 A P 0.966 Pathogenic MSH6 P52701 A465Q 465 A Q 0.656 Pathogenic MSH6 P52701 A465R 465 A R 0.802 Pathogenic MSH6 P52701 A465S 465 A S 0.148 Neutral MSH6 P52701 A465T 465 A T 0.446 Neutral MSH6 P52701 A465V 465 A V 0.832 Pathogenic MSH6 P52701 A465W 465 A W 0.99 Pathogenic MSH6 P52701 A465Y 465 A Y 0.956 Pathogenic MSH6 P52701 F466A 466 F A 0.132 Neutral MSH6 P52701 F466C 466 F C 0.574 Pathogenic MSH6 P52701 F466D 466 F D 0.78 Pathogenic MSH6 P52701 F466E 466 F E 0.86 Pathogenic MSH6 P52701 F466G 466 F G 0.48 Neutral MSH6 P52701 F466H 466 F H 0.268 Neutral MSH6 P52701 F466I 466 F I 0.562 Pathogenic MSH6 P52701 F466K 466 F K 0.844 Pathogenic MSH6 P52701 F466L 466 F L 0.072 Neutral MSH6 P52701 F466M 466 F M 0.65 Pathogenic MSH6 P52701 F466N 466 F N 0.7 Pathogenic MSH6 P52701 F466P 466 F P 0.944 Pathogenic MSH6 P52701 F466Q 466 F Q 0.732 Pathogenic MSH6 P52701 F466R 466 F R 0.536 Pathogenic MSH6 P52701 F466S 466 F S 0.762 Pathogenic MSH6 P52701 F466T 466 F T 0.592 Pathogenic MSH6 P52701 F466V 466 F V 0.842 Pathogenic MSH6 P52701 F466W 466 F W 0.944 Pathogenic MSH6 P52701 F466Y 466 F Y 0.254 Neutral MSH6 P52701 G467A 467 G A 0.074 Neutral MSH6 P52701 G467C 467 G C 0.81 Pathogenic MSH6 P52701 G467D 467 G D 0.458 Neutral MSH6 P52701 G467E 467 G E 0.558 Pathogenic MSH6 P52701 G467F 467 G F 0.782 Pathogenic MSH6 P52701 G467H 467 G H 0.916 Pathogenic MSH6 P52701 G467I 467 G I 0.932 Pathogenic MSH6 P52701 G467K 467 G K 0.972 Pathogenic MSH6 P52701 G467L 467 G L 0.968 Pathogenic MSH6 P52701 G467M 467 G M 0.984 Pathogenic MSH6 P52701 G467N 467 G N 0.57 Pathogenic MSH6 P52701 G467P 467 G P 0.914 Pathogenic MSH6 P52701 G467Q 467 G Q 0.548 Pathogenic MSH6 P52701 G467R 467 G R 0.902 Pathogenic MSH6 P52701 G467S 467 G S 0.084 Neutral MSH6 P52701 G467T 467 G T 0.56 Pathogenic MSH6 P52701 G467V 467 G V 0.974 Pathogenic MSH6 P52701 G467W 467 G W 0.956 Pathogenic MSH6 P52701 G467Y 467 G Y 0.946 Pathogenic MSH6 P52701 R468A 468 R A 0.428 Neutral MSH6 P52701 R468C 468 R C 0.666 Pathogenic MSH6 P52701 R468D 468 R D 0.64 Pathogenic MSH6 P52701 R468E 468 R E 0.222 Neutral MSH6 P52701 R468F 468 R F 0.936 Pathogenic MSH6 P52701 R468G 468 R G 0.212 Neutral MSH6 P52701 R468H 468 R H 0.01 Neutral 2 MSH6 P52701 R468I 468 R I 0.288 Neutral MSH6 P52701 R468K 468 R K 0.03 Neutral MSH6 P52701 R468L 468 R L 0.116 Neutral MSH6 P52701 R468M 468 R M 0.048 Neutral MSH6 P52701 R468N 468 R N 0.5 Pathogenic MSH6 P52701 R468P 468 R P 0.396 Neutral MSH6 P52701 R468Q 468 R Q 0.436 Neutral MSH6 P52701 R468S 468 R S 0.45 Neutral MSH6 P52701 R468T 468 R T 0.088 Neutral MSH6 P52701 R468V 468 R V 0.116 Neutral MSH6 P52701 R468W 468 R W 0.914 Pathogenic MSH6 P52701 R468Y 468 R Y 0.136 Neutral MSH6 P52701 Y469A 469 Y A 0.232 Neutral MSH6 P52701 Y469C 469 Y C 0.35 Neutral MSH6 P52701 Y469D 469 Y D 0.574 Pathogenic MSH6 P52701 Y469E 469 Y E 0.562 Pathogenic MSH6 P52701 Y469F 469 Y F 0.02 Neutral MSH6 P52701 Y469G 469 Y G 0.28 Neutral MSH6 P52701 Y469H 469 Y H 0.254 Neutral MSH6 P52701 Y469I 469 Y I 0.488 Neutral MSH6 P52701 Y469K 469 Y K 0.56 Pathogenic MSH6 P52701 Y469L 469 Y L 0.31 Neutral MSH6 P52701 Y469M 469 Y M 0.036 Neutral MSH6 P52701 Y469N 469 Y N 0.116 Neutral MSH6 P52701 Y469P 469 Y P 0.428 Neutral MSH6 P52701 Y469Q 469 Y Q 0.372 Neutral MSH6 P52701 Y469R 469 Y R 0.602 Pathogenic MSH6 P52701 Y469S 469 Y S 0.284 Neutral MSH6 P52701 Y469T 469 Y T 0.232 Neutral MSH6 P52701 Y469V 469 Y V 0.392 Neutral MSH6 P52701 Y469W 469 Y W 0.056 Neutral MSH6 P52701 D47A 47 D A 0.072 Neutral MSH6 P52701 D47C 47 D C 0.17 Neutral MSH6 P52701 D47E 47 D E 0.094 Neutral MSH6 P52701 D47F 47 D F 0.37 Neutral MSH6 P52701 D47G 47 D G 0.082 Neutral MSH6 P52701 D47H 47 D H 0.09 Neutral MSH6 P52701 D47I 47 D I 0.262 Neutral MSH6 P52701 D47K 47 D K 0.176 Neutral MSH6 P52701 D47L 47 D L 0.256 Neutral MSH6 P52701 D47M 47 D M 0.19 Neutral MSH6 P52701 D47N 47 D N 0.058 Neutral MSH6 P52701 D47P 47 D P 0.038 Neutral MSH6 P52701 D47Q 47 D Q 0.172 Neutral MSH6 P52701 D47R 47 D R 0.128 Neutral MSH6 P52701 D47S 47 D S 0.196 Neutral MSH6 P52701 D47T 47 D T 0.154 Neutral MSH6 P52701 D47V 47 D V 0.102 Neutral MSH6 P52701 D47W 47 D W 0.434 Neutral MSH6 P52701 D47Y 47 D Y 0.404 Neutral MSH6 P52701 S470A 470 S A 0.138 Neutral MSH6 P52701 S470C 470 S C 0.772 Pathogenic MSH6 P52701 S470D 470 S D 0.794 Pathogenic MSH6 P52701 S470E 470 S E 0.906 Pathogenic MSH6 P52701 S470F 470 S F 0.978 Pathogenic MSH6 P52701 S470G 470 S G 0.14 Neutral MSH6 P52701 S470H 470 S H 0.92 Pathogenic MSH6 P52701 S470I 470 S I 0.668 Pathogenic MSH6 P52701 S470K 470 S K 0.894 Pathogenic MSH6 P52701 S470L 470 S L 0.484 Neutral MSH6 P52701 S470M 470 S M 0.87 Pathogenic MSH6 P52701 S470N 470 S N 0.742 Pathogenic MSH6 P52701 S470P 470 S P 0.908 Pathogenic MSH6 P52701 S470Q 470 S Q 0.86 Pathogenic MSH6 P52701 S470R 470 S R 0.928 Pathogenic MSH6 P52701 S470T 470 S T 0.378 Neutral MSH6 P52701 S470V 470 S V 0.318 Neutral MSH6 P52701 S470W 470 S W 0.968 Pathogenic MSH6 P52701 S470Y 470 S Y 0.966 Pathogenic MSH6 P52701 D471A 471 D A 0.1 Neutral MSH6 P52701 D471C 471 D C 0.75 Pathogenic MSH6 P52701 D471E 471 D E 0.024 Neutral MSH6 P52701 D471F 471 D F 0.94 Pathogenic MSH6 P52701 D471G 471 D G 0.354 Neutral MSH6 P52701 D471H 471 D H 0.44 Neutral MSH6 P52701 D471I 471 D I 0.912 Pathogenic MSH6 P52701 D471K 471 D K 0.756 Pathogenic MSH6 P52701 D471L 471 D L 0.914 Pathogenic MSH6 P52701 D471M 471 D M 0.818 Pathogenic MSH6 P52701 D471N 471 D N 0.006 Neutral MSH6 P52701 D471P 471 D P 0.712 Pathogenic MSH6 P52701 D471Q 471 D Q 0.49 Neutral MSH6 P52701 D471R 471 D R 0.766 Pathogenic MSH6 P52701 D471S 471 D S 0.01 Neutral MSH6 P52701 D471T 471 D T 0.05 Neutral MSH6 P52701 D471V 471 D V 0.798 Pathogenic MSH6 P52701 D471W 471 D W 0.97 Pathogenic MSH6 P52701 D471Y 471 D Y 0.962 Pathogenic MSH6 P52701 S472A 472 S A 0.104 Neutral MSH6 P52701 S472C 472 S C 0.42 Neutral MSH6 P52701 S472D 472 S D 0.448 Neutral MSH6 P52701 S472E 472 S E 0.68 Pathogenic MSH6 P52701 S472F 472 S F 0.844 Pathogenic MSH6 P52701 S472G 472 S G 0.06 Neutral MSH6 P52701 S472H 472 S H 0.586 Pathogenic MSH6 P52701 S472I 472 S I 0.346 Neutral MSH6 P52701 S472K 472 S K 0.44 Neutral MSH6 P52701 S472L 472 S L 0.254 Neutral MSH6 P52701 S472M 472 S M 0.588 Pathogenic MSH6 P52701 S472N 472 S N 0.242 Neutral MSH6 P52701 S472P 472 S P 0.5 Pathogenic MSH6 P52701 S472Q 472 S Q 0.454 Neutral MSH6 P52701 S472R 472 S R 0.464 Neutral MSH6 P52701 S472T 472 S T 0.072 Neutral MSH6 P52701 S472V 472 S V 0.108 Neutral MSH6 P52701 S472W 472 S W 0.932 Pathogenic MSH6 P52701 S472Y 472 S Y 0.912 Pathogenic MSH6 P52701 L473A 473 L A 0.706 Pathogenic MSH6 P52701 L473C 473 L C 0.81 Pathogenic MSH6 P52701 L473D 473 L D 0.88 Pathogenic MSH6 P52701 L473E 473 L E 0.86 Pathogenic MSH6 P52701 L473F 473 L F 0.422 Neutral MSH6 P52701 L473G 473 L G 0.844 Pathogenic MSH6 P52701 L473H 473 L H 0.904 Pathogenic MSH6 P52701 L473I 473 L I 0.922 Pathogenic MSH6 P52701 L473K 473 L K 0.696 Pathogenic MSH6 P52701 L473M 473 L M 0.324 Neutral MSH6 P52701 L473N 473 L N 0.778 Pathogenic MSH6 P52701 L473P 473 L P 0.97 Pathogenic MSH6 P52701 L473Q 473 L Q 0.742 Pathogenic MSH6 P52701 L473R 473 L R 0.974 Pathogenic MSH6 P52701 L473S 473 L S 0.658 Pathogenic MSH6 P52701 L473T 473 L T 0.586 Pathogenic MSH6 P52701 L473V 473 L V 0.362 Neutral MSH6 P52701 L473W 473 L W 0.728 Pathogenic MSH6 P52701 L473Y 473 L Y 0.86 Pathogenic MSH6 P52701 V474A 474 V A 0.082 Neutral MSH6 P52701 V474C 474 V C 0.72 Pathogenic MSH6 P52701 V474D 474 V D 0.86 Pathogenic MSH6 P52701 V474E 474 V E 0.976 Pathogenic MSH6 P52701 V474F 474 V F 0.892 Pathogenic MSH6 P52701 V474G 474 V G 0.882 Pathogenic MSH6 P52701 V474H 474 V H 0.832 Pathogenic MSH6 P52701 V474I 474 V I 0.2 Neutral MSH6 P52701 V474K 474 V K 0.986 Pathogenic MSH6 P52701 V474L 474 V L 0.29 Neutral MSH6 P52701 V474M 474 V M 0.256 Neutral MSH6 P52701 V474N 474 V N 0.918 Pathogenic MSH6 P52701 V474P 474 V P 0.976 Pathogenic MSH6 P52701 V474Q 474 V Q 0.982 Pathogenic MSH6 P52701 V474R 474 V R 0.954 Pathogenic MSH6 P52701 V474S 474 V S 0.722 Pathogenic MSH6 P52701 V474T 474 V T 0.176 Neutral MSH6 P52701 V474W 474 V W 0.92 Pathogenic MSH6 P52701 V474Y 474 V Y 0.948 Pathogenic MSH6 P52701 Q475A 475 Q A 0.124 Neutral MSH6 P52701 Q475C 475 Q C 0.444 Neutral MSH6 P52701 Q475D 475 Q D 0.032 Neutral MSH6 P52701 Q475E 475 Q E 0.022 Neutral MSH6 P52701 Q475F 475 Q F 0.824 Pathogenic MSH6 P52701 Q475G 475 Q G 0.438 Neutral MSH6 P52701 Q475H 475 Q H 0.12 Neutral MSH6 P52701 Q475I 475 Q I 0.876 Pathogenic MSH6 P52701 Q475K 475 Q K 0.084 Neutral MSH6 P52701 Q475L 475 Q L 0.752 Pathogenic MSH6 P52701 Q475M 475 Q M 0.726 Pathogenic MSH6 P52701 Q475N 475 Q N 0.082 Neutral MSH6 P52701 Q475P 475 Q P 0.848 Pathogenic MSH6 P52701 Q475R 475 Q R 0.072 Neutral MSH6 P52701 Q475S 475 Q S 0.094 Neutral MSH6 P52701 Q475T 475 Q T 0.502 Pathogenic MSH6 P52701 Q475V 475 Q V 0.744 Pathogenic MSH6 P52701 Q475W 475 Q W 0.93 Pathogenic MSH6 P52701 Q475Y 475 Q Y 0.89 Pathogenic MSH6 P52701 K476A 476 K A 0.176 Neutral MSH6 P52701 K476C 476 K C 0.576 Pathogenic MSH6 P52701 K476D 476 K D 0.76 Pathogenic MSH6 P52701 K476E 476 K E 0.87 Pathogenic MSH6 P52701 K476F 476 K F 0.97 Pathogenic MSH6 P52701 K476G 476 K G 0.54 Pathogenic MSH6 P52701 K476H 476 K H 0.19 Neutral MSH6 P52701 K476I 476 K I 0.99 Pathogenic MSH6 P52701 K476L 476 K L 0.332 Neutral MSH6 P52701 K476M 476 K M 0.918 Pathogenic MSH6 P52701 K476N 476 K N 0.248 Neutral MSH6 P52701 K476P 476 K P 0.922 Pathogenic MSH6 P52701 K476Q 476 K Q 0.252 Neutral MSH6 P52701 K476R 476 K R 0.204 Neutral MSH6 P52701 K476S 476 K S 0.718 Pathogenic MSH6 P52701 K476T 476 K T 0.662 Pathogenic MSH6 P52701 K476V 476 K V 0.886 Pathogenic MSH6 P52701 K476W 476 K W 0.99 Pathogenic MSH6 P52701 K476Y 476 K Y 0.982 Pathogenic MSH6 P52701 G477A 477 G A 0.964 Pathogenic MSH6 P52701 G477C 477 G C 0.946 Pathogenic MSH6 P52701 G477D 477 G D 0.998 Pathogenic MSH6 P52701 G477E 477 G E 0.986 Pathogenic MSH6 P52701 G477F 477 G F 0.98 Pathogenic MSH6 P52701 G477H 477 G H 0.984 Pathogenic MSH6 P52701 G477I 477 G I 0.97 Pathogenic MSH6 P52701 G477K 477 G K 0.984 Pathogenic MSH6 P52701 G477L 477 G L 0.98 Pathogenic MSH6 P52701 G477M 477 G M 0.992 Pathogenic MSH6 P52701 G477N 477 G N 0.78 Pathogenic MSH6 P52701 G477P 477 G P 0.962 Pathogenic MSH6 P52701 G477Q 477 G Q 0.716 Pathogenic MSH6 P52701 G477R 477 G R 0.998 Pathogenic MSH6 P52701 G477S 477 G S 0.824 Pathogenic MSH6 P52701 G477T 477 G T 0.838 Pathogenic MSH6 P52701 G477V 477 G V 0.982 Pathogenic MSH6 P52701 G477W 477 G W 0.976 Pathogenic MSH6 P52701 G477Y 477 G Y 0.956 Pathogenic MSH6 P52701 Y478A 478 Y A 0.442 Neutral MSH6 P52701 Y478C 478 Y C 0.68 Pathogenic MSH6 P52701 Y478D 478 Y D 0.838 Pathogenic MSH6 P52701 Y478E 478 Y E 0.74 Pathogenic MSH6 P52701 Y478F 478 Y F 0.152 Neutral MSH6 P52701 Y478G 478 Y G 0.49 Neutral MSH6 P52701 Y478H 478 Y H 0.156 Neutral MSH6 P52701 Y478I 478 Y I 0.806 Pathogenic MSH6 P52701 Y478K 478 Y K 0.824 Pathogenic MSH6 P52701 Y478L 478 Y L 0.708 Pathogenic MSH6 P52701 Y478M 478 Y M 0.68 Pathogenic MSH6 P52701 Y478N 478 Y N 0.73 Pathogenic MSH6 P52701 Y478P 478 Y P 0.798 Pathogenic MSH6 P52701 Y478Q 478 Y Q 0.638 Pathogenic MSH6 P52701 Y478R 478 Y R 0.756 Pathogenic MSH6 P52701 Y478S 478 Y S 0.49 Neutral MSH6 P52701 Y478T 478 Y T 0.676 Pathogenic MSH6 P52701 Y478V 478 Y V 0.708 Pathogenic MSH6 P52701 Y478W 478 Y W 0.91 Pathogenic MSH6 P52701 K479A 479 K A 0.686 Pathogenic MSH6 P52701 K479C 479 K C 0.564 Pathogenic MSH6 P52701 K479D 479 K D 0.756 Pathogenic MSH6 P52701 K479E 479 K E 0.856 Pathogenic MSH6 P52701 K479F 479 K F 0.944 Pathogenic MSH6 P52701 K479G 479 K G 0.528 Pathogenic MSH6 P52701 K479H 479 K H 0.856 Pathogenic MSH6 P52701 K479I 479 K I 0.982 Pathogenic MSH6 P52701 K479L 479 K L 0.974 Pathogenic MSH6 P52701 K479M 479 K M 0.844 Pathogenic MSH6 P52701 K479N 479 K N 0.772 Pathogenic MSH6 P52701 K479P 479 K P 0.908 Pathogenic MSH6 P52701 K479Q 479 K Q 0.842 Pathogenic MSH6 P52701 K479R 479 K R 0.232 Neutral MSH6 P52701 K479S 479 K S 0.582 Pathogenic MSH6 P52701 K479T 479 K T 0.116 Neutral MSH6 P52701 K479V 479 K V 0.842 Pathogenic MSH6 P52701 K479W 479 K W 0.98 Pathogenic MSH6 P52701 K479Y 479 K Y 0.966 Pathogenic MSH6 P52701 A48C 48 A C 0.182 Neutral MSH6 P52701 A48D 48 A D 0.316 Neutral MSH6 P52701 A48E 48 A E 0.306 Neutral MSH6 P52701 A48F 48 A F 0.468 Neutral MSH6 P52701 A48G 48 A G 0.006 Neutral MSH6 P52701 A48H 48 A H 0.304 Neutral MSH6 P52701 A48I 48 A I 0.406 Neutral MSH6 P52701 A48K 48 A K 0.354 Neutral MSH6 P52701 A48L 48 A L 0.4 Neutral MSH6 P52701 A48M 48 A M 0.29 Neutral MSH6 P52701 A48N 48 A N 0.296 Neutral MSH6 P52701 A48P 48 A P 0.272 Neutral MSH6 P52701 A48Q 48 A Q 0.302 Neutral MSH6 P52701 A48R 48 A R 0.326 Neutral MSH6 P52701 A48S 48 A S 0.068 Neutral MSH6 P52701 A48T 48 A T 0.166 Neutral MSH6 P52701 A48V 48 A V 0.136 Neutral MSH6 P52701 A48W 48 A W 0.484 Neutral MSH6 P52701 A48Y 48 A Y 0.5 Pathogenic MSH6 P52701 V480A 480 V A 0.262 Neutral MSH6 P52701 V480C 480 V C 0.43 Neutral MSH6 P52701 V480D 480 V D 0.842 Pathogenic MSH6 P52701 V480E 480 V E 0.946 Pathogenic MSH6 P52701 V480F 480 V F 0.924 Pathogenic MSH6 P52701 V480G 480 V G 0.914 Pathogenic MSH6 P52701 V480H 480 V H 0.896 Pathogenic MSH6 P52701 V480I 480 V I 0.246 Neutral MSH6 P52701 V480K 480 V K 0.96 Pathogenic MSH6 P52701 V480L 480 V L 0.934 Pathogenic MSH6 P52701 V480M 480 V M 0.902 Pathogenic MSH6 P52701 V480N 480 V N 0.898 Pathogenic MSH6 P52701 V480P 480 V P 0.976 Pathogenic MSH6 P52701 V480Q 480 V Q 0.952 Pathogenic MSH6 P52701 V480R 480 V R 0.944 Pathogenic MSH6 P52701 V480S 480 V S 0.792 Pathogenic MSH6 P52701 V480T 480 V T 0.864 Pathogenic MSH6 P52701 V480W 480 V W 0.95 Pathogenic MSH6 P52701 V480Y 480 V Y 0.97 Pathogenic MSH6 P52701 A481C 481 A C 0.95 Pathogenic MSH6 P52701 A481D 481 A D 0.94 Pathogenic MSH6 P52701 A481E 481 A E 0.946 Pathogenic MSH6 P52701 A481F 481 A F 0.986 Pathogenic MSH6 P52701 A481G 481 A G 0.112 Neutral MSH6 P52701 A481H 481 A H 0.92 Pathogenic MSH6 P52701 A481I 481 A I 0.964 Pathogenic MSH6 P52701 A481K 481 A K 0.962 Pathogenic MSH6 P52701 A481L 481 A L 0.668 Pathogenic MSH6 P52701 A481M 481 A M 0.894 Pathogenic MSH6 P52701 A481N 481 A N 0.86 Pathogenic MSH6 P52701 A481P 481 A P 0.974 Pathogenic MSH6 P52701 A481Q 481 A Q 0.87 Pathogenic MSH6 P52701 A481R 481 A R 0.966 Pathogenic MSH6 P52701 A481S 481 A S 0.276 Neutral MSH6 P52701 A481T 481 A T 0.832 Pathogenic MSH6 P52701 A481V 481 A V 0.41 Neutral MSH6 P52701 A481W 481 A W 0.99 Pathogenic MSH6 P52701 A481Y 481 A Y 0.968 Pathogenic MSH6 P52701 R482A 482 R A 0.562 Pathogenic MSH6 P52701 R482C 482 R C 0.936 Pathogenic MSH6 P52701 R482D 482 R D 0.644 Pathogenic MSH6 P52701 R482E 482 R E 0.75 Pathogenic MSH6 P52701 R482F 482 R F 0.96 Pathogenic MSH6 P52701 R482G 482 R G 0.396 Neutral MSH6 P52701 R482H 482 R H 0.326 Neutral MSH6 P52701 R482I 482 R I 0.966 Pathogenic MSH6 P52701 R482K 482 R K 0.306 Neutral MSH6 P52701 R482L 482 R L 0.978 Pathogenic MSH6 P52701 R482M 482 R M 0.754 Pathogenic MSH6 P52701 R482N 482 R N 0.596 Pathogenic MSH6 P52701 R482P 482 R P 0.978 Pathogenic MSH6 P52701 R482Q 482 R Q 0.448 Neutral MSH6 P52701 R482S 482 R S 0.892 Pathogenic MSH6 P52701 R482T 482 R T 0.914 Pathogenic MSH6 P52701 R482V 482 R V 0.328 Neutral MSH6 P52701 R482W 482 R W 0.94 Pathogenic MSH6 P52701 R482Y 482 R Y 0.944 Pathogenic MSH6 P52701 V483A 483 V A 0.522 Pathogenic MSH6 P52701 V483C 483 V C 0.562 Pathogenic MSH6 P52701 V483D 483 V D 0.87 Pathogenic MSH6 P52701 V483E 483 V E 0.966 Pathogenic MSH6 P52701 V483F 483 V F 0.932 Pathogenic MSH6 P52701 V483G 483 V G 0.924 Pathogenic MSH6 P52701 V483H 483 V H 0.914 Pathogenic MSH6 P52701 V483I 483 V I 0.388 Neutral MSH6 P52701 V483K 483 V K 0.984 Pathogenic MSH6 P52701 V483L 483 V L 0.948 Pathogenic MSH6 P52701 V483M 483 V M 0.918 Pathogenic MSH6 P52701 V483N 483 V N 0.926 Pathogenic MSH6 P52701 V483P 483 V P 0.992 Pathogenic MSH6 P52701 V483Q 483 V Q 0.972 Pathogenic MSH6 P52701 V483R 483 V R 0.956 Pathogenic MSH6 P52701 V483S 483 V S 0.812 Pathogenic MSH6 P52701 V483T 483 V T 0.544 Pathogenic MSH6 P52701 V483W 483 V W 0.956 Pathogenic MSH6 P52701 V483Y 483 V Y 0.976 Pathogenic MSH6 P52701 E484A 484 E A 0.796 Pathogenic MSH6 P52701 E484C 484 E C 0.738 Pathogenic MSH6 P52701 E484D 484 E D 0.182 Neutral MSH6 P52701 E484F 484 E F 0.944 Pathogenic MSH6 P52701 E484G 484 E G 0.334 Neutral MSH6 P52701 E484H 484 E H 0.684 Pathogenic MSH6 P52701 E484I 484 E I 0.972 Pathogenic MSH6 P52701 E484K 484 E K 0.87 Pathogenic MSH6 P52701 E484L 484 E L 0.956 Pathogenic MSH6 P52701 E484M 484 E M 0.886 Pathogenic MSH6 P52701 E484N 484 E N 0.752 Pathogenic MSH6 P52701 E484P 484 E P 0.924 Pathogenic MSH6 P52701 E484Q 484 E Q 0.826 Pathogenic MSH6 P52701 E484R 484 E R 0.92 Pathogenic MSH6 P52701 E484S 484 E S 0.854 Pathogenic MSH6 P52701 E484T 484 E T 0.81 Pathogenic MSH6 P52701 E484V 484 E V 0.646 Pathogenic MSH6 P52701 E484W 484 E W 0.974 Pathogenic MSH6 P52701 E484Y 484 E Y 0.95 Pathogenic MSH6 P52701 Q485A 485 Q A 0.794 Pathogenic MSH6 P52701 Q485C 485 Q C 0.776 Pathogenic MSH6 P52701 Q485D 485 Q D 0.868 Pathogenic MSH6 P52701 Q485E 485 Q E 0.654 Pathogenic MSH6 P52701 Q485F 485 Q F 0.926 Pathogenic MSH6 P52701 Q485G 485 Q G 0.54 Pathogenic MSH6 P52701 Q485H 485 Q H 0.936 Pathogenic MSH6 P52701 Q485I 485 Q I 0.952 Pathogenic MSH6 P52701 Q485K 485 Q K 0.93 Pathogenic MSH6 P52701 Q485L 485 Q L 0.874 Pathogenic MSH6 P52701 Q485M 485 Q M 0.912 Pathogenic MSH6 P52701 Q485N 485 Q N 0.902 Pathogenic MSH6 P52701 Q485P 485 Q P 0.926 Pathogenic MSH6 P52701 Q485R 485 Q R 0.928 Pathogenic MSH6 P52701 Q485S 485 Q S 0.702 Pathogenic MSH6 P52701 Q485T 485 Q T 0.532 Pathogenic MSH6 P52701 Q485V 485 Q V 0.936 Pathogenic MSH6 P52701 Q485W 485 Q W 0.958 Pathogenic MSH6 P52701 Q485Y 485 Q Y 0.944 Pathogenic MSH6 P52701 T486A 486 T A 0.234 Neutral MSH6 P52701 T486C 486 T C 0.82 Pathogenic MSH6 P52701 T486D 486 T D 0.832 Pathogenic MSH6 P52701 T486E 486 T E 0.9 Pathogenic MSH6 P52701 T486F 486 T F 0.91 Pathogenic MSH6 P52701 T486G 486 T G 0.588 Pathogenic MSH6 P52701 T486H 486 T H 0.838 Pathogenic MSH6 P52701 T486I 486 T I 0.336 Neutral MSH6 P52701 T486K 486 T K 0.604 Pathogenic MSH6 P52701 T486L 486 T L 0.29 Neutral MSH6 P52701 T486M 486 T M 0.41 Neutral MSH6 P52701 T486N 486 T N 0.754 Pathogenic MSH6 P52701 T486P 486 T P 0.906 Pathogenic MSH6 P52701 T486Q 486 T Q 0.162 Neutral MSH6 P52701 T486R 486 T R 0.954 Pathogenic MSH6 P52701 T486S 486 T S 0.058 Neutral MSH6 P52701 T486V 486 T V 0.314 Neutral MSH6 P52701 T486W 486 T W 0.994 Pathogenic MSH6 P52701 T486Y 486 T Y 0.994 Pathogenic MSH6 P52701 E487A 487 E A 0.812 Pathogenic MSH6 P52701 E487C 487 E C 0.77 Pathogenic MSH6 P52701 E487D 487 E D 0.586 Pathogenic MSH6 P52701 E487F 487 E F 0.962 Pathogenic MSH6 P52701 E487G 487 E G 0.336 Neutral MSH6 P52701 E487H 487 E H 0.76 Pathogenic MSH6 P52701 E487I 487 E I 0.98 Pathogenic MSH6 P52701 E487K 487 E K 0.928 Pathogenic MSH6 P52701 E487L 487 E L 0.976 Pathogenic MSH6 P52701 E487M 487 E M 0.92 Pathogenic MSH6 P52701 E487N 487 E N 0.796 Pathogenic MSH6 P52701 E487P 487 E P 0.944 Pathogenic MSH6 P52701 E487Q 487 E Q 0.512 Pathogenic MSH6 P52701 E487R 487 E R 0.936 Pathogenic MSH6 P52701 E487S 487 E S 0.914 Pathogenic MSH6 P52701 E487T 487 E T 0.86 Pathogenic MSH6 P52701 E487V 487 E V 0.926 Pathogenic MSH6 P52701 E487W 487 E W 0.982 Pathogenic MSH6 P52701 E487Y 487 E Y 0.96 Pathogenic MSH6 P52701 T488A 488 T A 0.328 Neutral MSH6 P52701 T488C 488 T C 0.922 Pathogenic MSH6 P52701 T488D 488 T D 0.932 Pathogenic MSH6 P52701 T488E 488 T E 0.934 Pathogenic MSH6 P52701 T488F 488 T F 0.948 Pathogenic MSH6 P52701 T488G 488 T G 0.732 Pathogenic MSH6 P52701 T488H 488 T H 0.916 Pathogenic MSH6 P52701 T488I 488 T I 0.944 Pathogenic MSH6 P52701 T488K 488 T K 0.932 Pathogenic MSH6 P52701 T488L 488 T L 0.938 Pathogenic MSH6 P52701 T488M 488 T M 0.972 Pathogenic MSH6 P52701 T488N 488 T N 0.212 Neutral MSH6 P52701 T488P 488 T P 0.948 Pathogenic MSH6 P52701 T488Q 488 T Q 0.878 Pathogenic MSH6 P52701 T488R 488 T R 0.99 Pathogenic MSH6 P52701 T488S 488 T S 0.164 Neutral MSH6 P52701 T488V 488 T V 0.776 Pathogenic MSH6 P52701 T488W 488 T W 0.944 Pathogenic MSH6 P52701 T488Y 488 T Y 0.944 Pathogenic MSH6 P52701 P489A 489 P A 0.172 Neutral MSH6 P52701 P489C 489 P C 0.902 Pathogenic MSH6 P52701 P489D 489 P D 0.846 Pathogenic MSH6 P52701 P489E 489 P E 0.956 Pathogenic MSH6 P52701 P489F 489 P F 0.996 Pathogenic MSH6 P52701 P489G 489 P G 0.598 Pathogenic MSH6 P52701 P489H 489 P H 0.978 Pathogenic MSH6 P52701 P489I 489 P I 0.726 Pathogenic MSH6 P52701 P489K 489 P K 0.952 Pathogenic MSH6 P52701 P489L 489 P L 0.44 Neutral MSH6 P52701 P489M 489 P M 0.954 Pathogenic MSH6 P52701 P489N 489 P N 0.204 Neutral MSH6 P52701 P489Q 489 P Q 0.55 Pathogenic MSH6 P52701 P489R 489 P R 0.98 Pathogenic MSH6 P52701 P489S 489 P S 0.112 Neutral MSH6 P52701 P489T 489 P T 0.416 Neutral MSH6 P52701 P489V 489 P V 0.258 Neutral MSH6 P52701 P489W 489 P W 0.94 Pathogenic MSH6 P52701 P489Y 489 P Y 0.94 Pathogenic MSH6 P52701 A49C 49 A C 0.182 Neutral MSH6 P52701 A49D 49 A D 0.316 Neutral MSH6 P52701 A49E 49 A E 0.276 Neutral MSH6 P52701 A49F 49 A F 0.468 Neutral MSH6 P52701 A49G 49 A G 0.006 Neutral MSH6 P52701 A49H 49 A H 0.304 Neutral MSH6 P52701 A49I 49 A I 0.406 Neutral MSH6 P52701 A49K 49 A K 0.272 Neutral MSH6 P52701 A49L 49 A L 0.4 Neutral MSH6 P52701 A49M 49 A M 0.29 Neutral MSH6 P52701 A49N 49 A N 0.296 Neutral MSH6 P52701 A49P 49 A P 0.272 Neutral MSH6 P52701 A49Q 49 A Q 0.286 Neutral MSH6 P52701 A49R 49 A R 0.318 Neutral MSH6 P52701 A49S 49 A S 0.024 Neutral MSH6 P52701 A49T 49 A T 0.172 Neutral MSH6 P52701 A49V 49 A V 0.202 Neutral MSH6 P52701 A49W 49 A W 0.504 Pathogenic MSH6 P52701 A49Y 49 A Y 0.5 Pathogenic MSH6 P52701 E490A 490 E A 0.544 Pathogenic MSH6 P52701 E490C 490 E C 0.488 Neutral MSH6 P52701 E490D 490 E D 0.018 Neutral MSH6 P52701 E490F 490 E F 0.88 Pathogenic MSH6 P52701 E490G 490 E G 0.208 Neutral MSH6 P52701 E490H 490 E H 0.62 Pathogenic MSH6 P52701 E490I 490 E I 0.936 Pathogenic MSH6 P52701 E490K 490 E K 0.734 Pathogenic MSH6 P52701 E490L 490 E L 0.812 Pathogenic MSH6 P52701 E490M 490 E M 0.724 Pathogenic MSH6 P52701 E490N 490 E N 0.106 Neutral MSH6 P52701 E490P 490 E P 0.76 Pathogenic MSH6 P52701 E490Q 490 E Q 0.012 Neutral MSH6 P52701 E490R 490 E R 0.586 Pathogenic MSH6 P52701 E490S 490 E S 0.416 Neutral MSH6 P52701 E490T 490 E T 0.118 Neutral MSH6 P52701 E490V 490 E V 0.848 Pathogenic MSH6 P52701 E490W 490 E W 0.972 Pathogenic MSH6 P52701 E490Y 490 E Y 0.922 Pathogenic MSH6 P52701 M491A 491 M A 0.12 Neutral MSH6 P52701 M491C 491 M C 0.25 Neutral MSH6 P52701 M491D 491 M D 0.674 Pathogenic MSH6 P52701 M491E 491 M E 0.444 Neutral MSH6 P52701 M491F 491 M F 0.766 Pathogenic MSH6 P52701 M491G 491 M G 0.286 Neutral MSH6 P52701 M491H 491 M H 0.516 Pathogenic MSH6 P52701 M491I 491 M I 0.594 Pathogenic MSH6 P52701 M491K 491 M K 0.692 Pathogenic MSH6 P52701 M491L 491 M L 0.578 Pathogenic MSH6 P52701 M491N 491 M N 0.692 Pathogenic MSH6 P52701 M491P 491 M P 0.872 Pathogenic MSH6 P52701 M491Q 491 M Q 0.02 Neutral MSH6 P52701 M491R 491 M R 0.716 Pathogenic MSH6 P52701 M491S 491 M S 0.372 Neutral MSH6 P52701 M491T 491 M T 0.44 Neutral MSH6 P52701 M491V 491 M V 0.484 Neutral MSH6 P52701 M491W 491 M W 0.948 Pathogenic MSH6 P52701 M491Y 491 M Y 0.884 Pathogenic MSH6 P52701 M492A 492 M A 0.6 Pathogenic MSH6 P52701 M492C 492 M C 0.518 Pathogenic MSH6 P52701 M492D 492 M D 0.838 Pathogenic MSH6 P52701 M492E 492 M E 0.76 Pathogenic MSH6 P52701 M492F 492 M F 0.85 Pathogenic MSH6 P52701 M492G 492 M G 0.514 Pathogenic MSH6 P52701 M492H 492 M H 0.87 Pathogenic MSH6 P52701 M492I 492 M I 0.32 Neutral MSH6 P52701 M492K 492 M K 0.92 Pathogenic MSH6 P52701 M492L 492 M L 0.202 Neutral MSH6 P52701 M492N 492 M N 0.202 Neutral MSH6 P52701 M492P 492 M P 0.916 Pathogenic MSH6 P52701 M492Q 492 M Q 0.718 Pathogenic MSH6 P52701 M492R 492 M R 0.55 Pathogenic MSH6 P52701 M492S 492 M S 0.412 Neutral MSH6 P52701 M492T 492 M T 0.362 Neutral MSH6 P52701 M492V 492 M V 0.224 Neutral MSH6 P52701 M492W 492 M W 0.986 Pathogenic MSH6 P52701 M492Y 492 M Y 0.89 Pathogenic MSH6 P52701 E493A 493 E A 0.208 Neutral MSH6 P52701 E493C 493 E C 0.502 Pathogenic MSH6 P52701 E493D 493 E D 0.042 Neutral MSH6 P52701 E493F 493 E F 0.886 Pathogenic MSH6 P52701 E493G 493 E G 0.032 Neutral MSH6 P52701 E493H 493 E H 0.604 Pathogenic MSH6 P52701 E493I 493 E I 0.94 Pathogenic MSH6 P52701 E493K 493 E K 0.044 Neutral MSH6 P52701 E493L 493 E L 0.904 Pathogenic MSH6 P52701 E493M 493 E M 0.71 Pathogenic MSH6 P52701 E493N 493 E N 0.018 Neutral MSH6 P52701 E493P 493 E P 0.886 Pathogenic MSH6 P52701 E493Q 493 E Q 0.012 Neutral MSH6 P52701 E493R 493 E R 0.62 Pathogenic MSH6 P52701 E493S 493 E S 0.044 Neutral MSH6 P52701 E493T 493 E T 0.042 Neutral MSH6 P52701 E493V 493 E V 0.846 Pathogenic MSH6 P52701 E493W 493 E W 0.964 Pathogenic MSH6 P52701 E493Y 493 E Y 0.922 Pathogenic MSH6 P52701 A494C 494 A C 0.724 Pathogenic MSH6 P52701 A494D 494 A D 0.854 Pathogenic MSH6 P52701 A494E 494 A E 0.596 Pathogenic MSH6 P52701 A494F 494 A F 0.968 Pathogenic MSH6 P52701 A494G 494 A G 0.484 Neutral MSH6 P52701 A494H 494 A H 0.872 Pathogenic MSH6 P52701 A494I 494 A I 0.62 Pathogenic MSH6 P52701 A494K 494 A K 0.548 Pathogenic MSH6 P52701 A494L 494 A L 0.604 Pathogenic MSH6 P52701 A494M 494 A M 0.55 Pathogenic MSH6 P52701 A494N 494 A N 0.602 Pathogenic MSH6 P52701 A494P 494 A P 0.884 Pathogenic MSH6 P52701 A494Q 494 A Q 0.528 Pathogenic MSH6 P52701 A494R 494 A R 0.912 Pathogenic MSH6 P52701 A494S 494 A S 0.166 Neutral MSH6 P52701 A494T 494 A T 0.206 Neutral MSH6 P52701 A494V 494 A V 0.146 Neutral MSH6 P52701 A494W 494 A W 0.954 Pathogenic MSH6 P52701 A494Y 494 A Y 0.94 Pathogenic MSH6 P52701 R495A 495 R A 0.202 Neutral MSH6 P52701 R495C 495 R C 0.946 Pathogenic MSH6 P52701 R495D 495 R D 0.194 Neutral MSH6 P52701 R495E 495 R E 0.188 Neutral MSH6 P52701 R495F 495 R F 0.972 Pathogenic MSH6 P52701 R495G 495 R G 0.414 Neutral MSH6 P52701 R495H 495 R H 0.374 Neutral MSH6 P52701 R495I 495 R I 0.974 Pathogenic MSH6 P52701 R495K 495 R K 0.846 Pathogenic MSH6 P52701 R495L 495 R L 0.984 Pathogenic MSH6 P52701 R495M 495 R M 0.8 Pathogenic MSH6 P52701 R495N 495 R N 0.14 Neutral MSH6 P52701 R495P 495 R P 0.984 Pathogenic MSH6 P52701 R495Q 495 R Q 0.632 Pathogenic MSH6 P52701 R495S 495 R S 0.206 Neutral MSH6 P52701 R495T 495 R T 0.916 Pathogenic MSH6 P52701 R495V 495 R V 0.972 Pathogenic MSH6 P52701 R495W 495 R W 0.97 Pathogenic MSH6 P52701 R495Y 495 R Y 0.972 Pathogenic MSH6 P52701 C496A 496 C A 0.276 Neutral MSH6 P52701 C496D 496 C D 0.524 Pathogenic MSH6 P52701 C496E 496 C E 0.324 Neutral MSH6 P52701 C496F 496 C F 0.966 Pathogenic MSH6 P52701 C496G 496 C G 0.512 Pathogenic MSH6 P52701 C496H 496 C H 0.754 Pathogenic MSH6 P52701 C496I 496 C I 0.156 Neutral MSH6 P52701 C496K 496 C K 0.2 Neutral MSH6 P52701 C496L 496 C L 0.818 Pathogenic MSH6 P52701 C496M 496 C M 0.096 Neutral MSH6 P52701 C496N 496 C N 0.012 Neutral MSH6 P52701 C496P 496 C P 0.866 Pathogenic MSH6 P52701 C496Q 496 C Q 0.508 Pathogenic MSH6 P52701 C496R 496 C R 0.908 Pathogenic MSH6 P52701 C496S 496 C S 0.218 Neutral MSH6 P52701 C496T 496 C T 0.018 Neutral MSH6 P52701 C496V 496 C V 0.088 Neutral MSH6 P52701 C496W 496 C W 0.952 Pathogenic MSH6 P52701 C496Y 496 C Y 0.75 Pathogenic MSH6 P52701 R497A 497 R A 0.338 Neutral MSH6 P52701 R497C 497 R C 0.47 Neutral MSH6 P52701 R497D 497 R D 0.618 Pathogenic MSH6 P52701 R497E 497 R E 0.418 Neutral MSH6 P52701 R497F 497 R F 0.936 Pathogenic MSH6 P52701 R497G 497 R G 0.21 Neutral MSH6 P52701 R497H 497 R H 0.406 Neutral MSH6 P52701 R497I 497 R I 0.902 Pathogenic MSH6 P52701 R497K 497 R K 0.062 Neutral MSH6 P52701 R497L 497 R L 0.88 Pathogenic MSH6 P52701 R497M 497 R M 0.668 Pathogenic MSH6 P52701 R497N 497 R N 0.024 Neutral MSH6 P52701 R497P 497 R P 0.846 Pathogenic MSH6 P52701 R497Q 497 R Q 0.05 Neutral MSH6 P52701 R497S 497 R S 0.062 Neutral MSH6 P52701 R497T 497 R T 0.536 Pathogenic MSH6 P52701 R497V 497 R V 0.822 Pathogenic MSH6 P52701 R497W 497 R W 0.914 Pathogenic MSH6 P52701 R497Y 497 R Y 0.892 Pathogenic MSH6 P52701 K498A 498 K A 0.032 Neutral MSH6 P52701 K498C 498 K C 0.056 Neutral MSH6 P52701 K498D 498 K D 0.098 Neutral MSH6 P52701 K498E 498 K E 0.004 Neutral MSH6 P52701 K498F 498 K F 0.382 Neutral MSH6 P52701 K498G 498 K G 0.048 Neutral MSH6 P52701 K498H 498 K H 0.004 Neutral MSH6 P52701 K498I 498 K I 0.184 Neutral MSH6 P52701 K498L 498 K L 0.046 Neutral MSH6 P52701 K498M 498 K M 0.184 Neutral MSH6 P52701 K498N 498 K N 0.008 Neutral MSH6 P52701 K498P 498 K P 0.384 Neutral MSH6 P52701 K498Q 498 K Q 0.01 Neutral MSH6 P52701 K498R 498 K R 0.006 Neutral MSH6 P52701 K498S 498 K S 0.014 Neutral MSH6 P52701 K498T 498 K T 0.014 Neutral MSH6 P52701 K498V 498 K V 0.048 Neutral MSH6 P52701 K498W 498 K W 0.672 Pathogenic MSH6 P52701 K498Y 498 K Y 0.576 Pathogenic MSH6 P52701 M499A 499 M A 0.166 Neutral MSH6 P52701 M499C 499 M C 0.228 Neutral MSH6 P52701 M499D 499 M D 0.128 Neutral MSH6 P52701 M499E 499 M E 0.044 Neutral MSH6 P52701 M499F 499 M F 0.74 Pathogenic MSH6 P52701 M499G 499 M G 0.362 Neutral MSH6 P52701 M499H 499 M H 0.326 Neutral MSH6 P52701 M499I 499 M I 0.05 Neutral MSH6 P52701 M499K 499 M K 0.066 Neutral MSH6 P52701 M499L 499 M L 0.034 Neutral MSH6 P52701 M499N 499 M N 0.12 Neutral MSH6 P52701 M499P 499 M P 0.81 Pathogenic MSH6 P52701 M499Q 499 M Q 0.042 Neutral MSH6 P52701 M499R 499 M R 0.1 Neutral MSH6 P52701 M499S 499 M S 0.06 Neutral MSH6 P52701 M499T 499 M T 0.046 Neutral MSH6 P52701 M499V 499 M V 0.48 Neutral MSH6 P52701 M499W 499 M W 0.896 Pathogenic MSH6 P52701 M499Y 499 M Y 0.794 Pathogenic MSH6 P52701 S5A 5 S A 0.086 Neutral MSH6 P52701 S5C 5 S C 0.032 Neutral MSH6 P52701 S5D 5 S D 0.044 Neutral MSH6 P52701 S5E 5 S E 0.148 Neutral MSH6 P52701 S5F 5 S F 0.276 Neutral MSH6 P52701 S5G 5 S G 0.064 Neutral MSH6 P52701 S5H 5 S H 0.238 Neutral MSH6 P52701 S5I 5 S I 0.026 Neutral MSH6 P52701 S5K 5 S K 0.164 Neutral MSH6 P52701 S5L 5 S L 0.028 Neutral MSH6 P52701 S5M 5 S M 0.25 Neutral MSH6 P52701 S5N 5 S N 0.012 Neutral MSH6 P52701 S5P 5 S P 0.116 Neutral MSH6 P52701 S5Q 5 S Q 0.158 Neutral MSH6 P52701 S5R 5 S R 0.248 Neutral MSH6 P52701 S5T 5 S T 0.11 Neutral MSH6 P52701 S5V 5 S V 0.248 Neutral MSH6 P52701 S5W 5 S W 0.49 Neutral MSH6 P52701 S5Y 5 S Y 0.448 Neutral MSH6 P52701 W50A 50 W A 0.122 Neutral MSH6 P52701 W50C 50 W C 0.104 Neutral MSH6 P52701 W50D 50 W D 0.14 Neutral MSH6 P52701 W50E 50 W E 0.05 Neutral MSH6 P52701 W50F 50 W F 0.056 Neutral MSH6 P52701 W50G 50 W G 0.152 Neutral MSH6 P52701 W50H 50 W H 0.092 Neutral MSH6 P52701 W50I 50 W I 0.088 Neutral MSH6 P52701 W50K 50 W K 0.054 Neutral MSH6 P52701 W50L 50 W L 0.076 Neutral MSH6 P52701 W50M 50 W M 0.088 Neutral MSH6 P52701 W50N 50 W N 0.106 Neutral MSH6 P52701 W50P 50 W P 0.106 Neutral MSH6 P52701 W50Q 50 W Q 0.13 Neutral MSH6 P52701 W50R 50 W R 0.044 Neutral MSH6 P52701 W50S 50 W S 0.164 Neutral MSH6 P52701 W50T 50 W T 0.104 Neutral MSH6 P52701 W50V 50 W V 0.078 Neutral MSH6 P52701 W50Y 50 W Y 0.136 Neutral MSH6 P52701 A500C 500 A C 0.716 Pathogenic MSH6 P52701 A500D 500 A D 0.856 Pathogenic MSH6 P52701 A500E 500 A E 0.856 Pathogenic MSH6 P52701 A500F 500 A F 0.968 Pathogenic MSH6 P52701 A500G 500 A G 0.032 Neutral MSH6 P52701 A500H 500 A H 0.56 Pathogenic MSH6 P52701 A500I 500 A I 0.686 Pathogenic MSH6 P52701 A500K 500 A K 0.556 Pathogenic MSH6 P52701 A500L 500 A L 0.93 Pathogenic MSH6 P52701 A500M 500 A M 0.838 Pathogenic MSH6 P52701 A500N 500 A N 0.584 Pathogenic MSH6 P52701 A500P 500 A P 0.872 Pathogenic MSH6 P52701 A500Q 500 A Q 0.796 Pathogenic MSH6 P52701 A500R 500 A R 0.636 Pathogenic MSH6 P52701 A500S 500 A S 0.022 Neutral MSH6 P52701 A500T 500 A T 0.066 Neutral MSH6 P52701 A500V 500 A V 0.166 Neutral MSH6 P52701 A500W 500 A W 0.954 Pathogenic MSH6 P52701 A500Y 500 A Y 0.94 Pathogenic MSH6 P52701 H501A 501 H A 0.116 Neutral MSH6 P52701 H501C 501 H C 0.066 Neutral MSH6 P52701 H501D 501 H D 0 Neutral MSH6 P52701 H501E 501 H E 0 Neutral MSH6 P52701 H501F 501 H F 0.364 Neutral MSH6 P52701 H501G 501 H G 0.044 Neutral MSH6 P52701 H501I 501 H I 0.194 Neutral MSH6 P52701 H501K 501 H K 0.006 Neutral MSH6 P52701 H501L 501 H L 0.392 Neutral MSH6 P52701 H501M 501 H M 0.196 Neutral MSH6 P52701 H501N 501 H N 0.002 Neutral MSH6 P52701 H501P 501 H P 0.466 Neutral MSH6 P52701 H501Q 501 H Q 0.006 Neutral MSH6 P52701 H501R 501 H R 0 Neutral MSH6 P52701 H501S 501 H S 0.014 Neutral MSH6 P52701 H501T 501 H T 0.024 Neutral MSH6 P52701 H501V 501 H V 0.232 Neutral MSH6 P52701 H501W 501 H W 0.686 Pathogenic MSH6 P52701 H501Y 501 H Y 0.43 Neutral MSH6 P52701 I502A 502 I A 0.016 Neutral MSH6 P52701 I502C 502 I C 0.15 Neutral MSH6 P52701 I502D 502 I D 0.23 Neutral MSH6 P52701 I502E 502 I E 0.224 Neutral MSH6 P52701 I502F 502 I F 0.352 Neutral MSH6 P52701 I502G 502 I G 0.216 Neutral MSH6 P52701 I502H 502 I H 0.156 Neutral MSH6 P52701 I502K 502 I K 0.056 Neutral MSH6 P52701 I502L 502 I L 0.02 Neutral MSH6 P52701 I502M 502 I M 0.176 Neutral MSH6 P52701 I502N 502 I N 0.112 Neutral MSH6 P52701 I502P 502 I P 0.072 Neutral MSH6 P52701 I502Q 502 I Q 0.288 Neutral MSH6 P52701 I502R 502 I R 0.376 Neutral MSH6 P52701 I502S 502 I S 0.082 Neutral MSH6 P52701 I502T 502 I T 0.012 Neutral MSH6 P52701 I502V 502 I V 0.004 Neutral MSH6 P52701 I502W 502 I W 0.552 Pathogenic MSH6 P52701 I502Y 502 I Y 0.51 Pathogenic MSH6 P52701 S503A 503 S A 0.014 Neutral MSH6 P52701 S503C 503 S C 0.12 Neutral 2 MSH6 P52701 S503D 503 S D 0.154 Neutral MSH6 P52701 S503E 503 S E 0.392 Neutral MSH6 P52701 S503F 503 S F 0.62 Pathogenic MSH6 P52701 S503G 503 S G 0.006 Neutral MSH6 P52701 S503H 503 S H 0.526 Pathogenic MSH6 P52701 S503I 503 S I 0.244 Neutral MSH6 P52701 S503K 503 S K 0.318 Neutral MSH6 P52701 S503L 503 S L 0.24 Neutral MSH6 P52701 S503M 503 S M 0.698 Pathogenic MSH6 P52701 S503N 503 S N 0.102 Neutral MSH6 P52701 S503P 503 S P 0.102 Neutral MSH6 P52701 S503Q 503 S Q 0.334 Neutral MSH6 P52701 S503R 503 S R 0.532 Pathogenic MSH6 P52701 S503T 503 S T 0.026 Neutral MSH6 P52701 S503V 503 S V 0.272 Neutral MSH6 P52701 S503W 503 S W 0.834 Pathogenic MSH6 P52701 S503Y 503 S Y 0.798 Pathogenic MSH6 P52701 K504A 504 K A 0.14 Neutral MSH6 P52701 K504C 504 K C 0.376 Neutral MSH6 P52701 K504D 504 K D 0.204 Neutral MSH6 P52701 K504E 504 K E 0.23 Neutral MSH6 P52701 K504F 504 K F 0.852 Pathogenic MSH6 P52701 K504G 504 K G 0.52 Pathogenic MSH6 P52701 K504H 504 K H 0.62 Pathogenic MSH6 P52701 K504I 504 K I 0.956 Pathogenic MSH6 P52701 K504L 504 K L 0.936 Pathogenic MSH6 P52701 K504M 504 K M 0.726 Pathogenic MSH6 P52701 K504N 504 K N 0.584 Pathogenic MSH6 P52701 K504P 504 K P 0.342 Neutral MSH6 P52701 K504Q 504 K Q 0.154 Neutral MSH6 P52701 K504R 504 K R 0.124 Neutral MSH6 P52701 K504S 504 K S 0.14 Neutral MSH6 P52701 K504T 504 K T 0.128 Neutral MSH6 P52701 K504V 504 K V 0.776 Pathogenic MSH6 P52701 K504W 504 K W 0.948 Pathogenic MSH6 P52701 K504Y 504 K Y 0.916 Pathogenic MSH6 P52701 Y505A 505 Y A 0.114 Neutral MSH6 P52701 Y505C 505 Y C 0.324 Neutral MSH6 P52701 Y505D 505 Y D 0.356 Neutral MSH6 P52701 Y505E 505 Y E 0.088 Neutral MSH6 P52701 Y505F 505 Y F 0.028 Neutral MSH6 P52701 Y505G 505 Y G 0.17 Neutral MSH6 P52701 Y505H 505 Y H 0.03 Neutral MSH6 P52701 Y505I 505 Y I 0.352 Neutral MSH6 P52701 Y505K 505 Y K 0.058 Neutral MSH6 P52701 Y505L 505 Y L 0.052 Neutral MSH6 P52701 Y505M 505 Y M 0.326 Neutral MSH6 P52701 Y505N 505 Y N 0.446 Neutral MSH6 P52701 Y505P 505 Y P 0.354 Neutral MSH6 P52701 Y505Q 505 Y Q 0.112 Neutral MSH6 P52701 Y505R 505 Y R 0.158 Neutral MSH6 P52701 Y505S 505 Y S 0.17 Neutral MSH6 P52701 Y505T 505 Y T 0.186 Neutral MSH6 P52701 Y505V 505 Y V 0.264 Neutral MSH6 P52701 Y505W 505 Y W 0.368 Neutral MSH6 P52701 D506A 506 D A 0.262 Neutral MSH6 P52701 D506C 506 D C 0.922 Pathogenic MSH6 P52701 D506E 506 D E 0.222 Neutral MSH6 P52701 D506F 506 D F 0.984 Pathogenic MSH6 P52701 D506G 506 D G 0.188 Neutral MSH6 P52701 D506H 506 D H 0.622 Pathogenic MSH6 P52701 D506I 506 D I 0.972 Pathogenic MSH6 P52701 D506K 506 D K 0.46 Neutral MSH6 P52701 D506L 506 D L 0.982 Pathogenic MSH6 P52701 D506M 506 D M 0.964 Pathogenic MSH6 P52701 D506N 506 D N 0.186 Neutral MSH6 P52701 D506P 506 D P 0.388 Neutral MSH6 P52701 D506Q 506 D Q 0.768 Pathogenic MSH6 P52701 D506R 506 D R 0.92 Pathogenic MSH6 P52701 D506S 506 D S 0.112 Neutral MSH6 P52701 D506T 506 D T 0.298 Neutral MSH6 P52701 D506V 506 D V 0.992 Pathogenic MSH6 P52701 D506W 506 D W 0.986 Pathogenic MSH6 P52701 D506Y 506 D Y 0.98 Pathogenic MSH6 P52701 R507A 507 R A 0.224 Neutral MSH6 P52701 R507C 507 R C 0.96 Pathogenic MSH6 P52701 R507D 507 R D 0.872 Pathogenic MSH6 P52701 R507E 507 R E 0.36 Neutral MSH6 P52701 R507F 507 R F 0.974 Pathogenic MSH6 P52701 R507G 507 R G 0.148 Neutral MSH6 P52701 R507H 507 R H 0.568 Pathogenic MSH6 P52701 R507I 507 R I 0.976 Pathogenic MSH6 P52701 R507K 507 R K 0.542 Pathogenic MSH6 P52701 R507L 507 R L 0.686 Pathogenic MSH6 P52701 R507M 507 R M 0.806 Pathogenic MSH6 P52701 R507N 507 R N 0.77 Pathogenic MSH6 P52701 R507P 507 R P 0.99 Pathogenic MSH6 P52701 R507Q 507 R Q 0.632 Pathogenic MSH6 P52701 R507S 507 R S 0.166 Neutral MSH6 P52701 R507T 507 R T 0.942 Pathogenic MSH6 P52701 R507V 507 R V 0.456 Neutral MSH6 P52701 R507W 507 R W 0.97 Pathogenic MSH6 P52701 R507Y 507 R Y 0.976 Pathogenic MSH6 P52701 V508A 508 V A 0.104 Neutral MSH6 P52701 V508C 508 V C 0.336 Neutral MSH6 P52701 V508D 508 V D 0.556 Pathogenic MSH6 P52701 V508E 508 V E 0.67 Pathogenic MSH6 P52701 V508F 508 V F 0.622 Pathogenic MSH6 P52701 V508G 508 V G 0.592 Pathogenic MSH6 P52701 V508H 508 V H 0.504 Pathogenic MSH6 P52701 V508I 508 V I 0.534 Pathogenic MSH6 P52701 V508K 508 V K 0.758 Pathogenic MSH6 P52701 V508L 508 V L 0.516 Pathogenic MSH6 P52701 V508M 508 V M 0.448 Neutral MSH6 P52701 V508N 508 V N 0.592 Pathogenic MSH6 P52701 V508P 508 V P 0.83 Pathogenic MSH6 P52701 V508Q 508 V Q 0.684 Pathogenic MSH6 P52701 V508R 508 V R 0.832 Pathogenic MSH6 P52701 V508S 508 V S 0.392 Neutral MSH6 P52701 V508T 508 V T 0.03 Neutral MSH6 P52701 V508W 508 V W 0.818 Pathogenic MSH6 P52701 V508Y 508 V Y 0.81 Pathogenic MSH6 P52701 V509A 509 V A 0.104 Neutral 2 MSH6 P52701 V509C 509 V C 0.336 Neutral MSH6 P52701 V509D 509 V D 0.554 Pathogenic MSH6 P52701 V509E 509 V E 0.534 Pathogenic MSH6 P52701 V509F 509 V F 0.74 Pathogenic MSH6 P52701 V509G 509 V G 0.59 Pathogenic MSH6 P52701 V509H 509 V H 0.504 Pathogenic MSH6 P52701 V509I 509 V I 0.388 Neutral MSH6 P52701 V509K 509 V K 0.756 Pathogenic MSH6 P52701 V509L 509 V L 0.13 Neutral MSH6 P52701 V509M 509 V M 0.448 Neutral MSH6 P52701 V509N 509 V N 0.59 Pathogenic MSH6 P52701 V509P 509 V P 0.826 Pathogenic MSH6 P52701 V509Q 509 V Q 0.682 Pathogenic MSH6 P52701 V509R 509 V R 0.832 Pathogenic MSH6 P52701 V509S 509 V S 0.392 Neutral MSH6 P52701 V509T 509 V T 0.322 Neutral MSH6 P52701 V509W 509 V W 0.818 Pathogenic MSH6 P52701 V509Y 509 V Y 0.81 Pathogenic MSH6 P52701 S51A 51 S A 0.01 Neutral MSH6 P52701 S51C 51 S C 0.032 Neutral MSH6 P52701 S51D 51 S D 0.044 Neutral MSH6 P52701 S51E 51 S E 0.124 Neutral MSH6 P52701 S51F 51 S F 0.276 Neutral MSH6 P52701 S51G 51 S G 0.036 Neutral MSH6 P52701 S51H 51 S H 0.238 Neutral MSH6 P52701 S51I 51 S I 0.026 Neutral MSH6 P52701 S51K 51 S K 0.146 Neutral MSH6 P52701 S51L 51 S L 0.028 Neutral MSH6 P52701 S51M 51 S M 0.332 Neutral MSH6 P52701 S51N 51 S N 0.012 Neutral MSH6 P52701 S51P 51 S P 0.066 Neutral MSH6 P52701 S51Q 51 S Q 0.158 Neutral MSH6 P52701 S51R 51 S R 0.248 Neutral MSH6 P52701 S51T 51 S T 0.02 Neutral MSH6 P52701 S51V 51 S V 0.248 Neutral MSH6 P52701 S51W 51 S W 0.49 Neutral MSH6 P52701 S51Y 51 S Y 0.448 Neutral MSH6 P52701 R510A 510 R A 0.068 Neutral MSH6 P52701 R510C 510 R C 0.42 Neutral MSH6 P52701 R510D 510 R D 0.434 Neutral MSH6 P52701 R510E 510 R E 0.428 Neutral MSH6 P52701 R510F 510 R F 0.64 Pathogenic MSH6 P52701 R510G 510 R G 0.176 Neutral MSH6 P52701 R510H 510 R H 0.026 Neutral MSH6 P52701 R510I 510 R I 0.656 Pathogenic MSH6 P52701 R510K 510 R K 0.02 Neutral MSH6 P52701 R510L 510 R L 0.624 Pathogenic MSH6 P52701 R510M 510 R M 0.426 Neutral MSH6 P52701 R510N 510 R N 0.06 Neutral MSH6 P52701 R510P 510 R P 0.578 Pathogenic MSH6 P52701 R510Q 510 R Q 0.382 Neutral MSH6 P52701 R510S 510 R S 0.038 Neutral MSH6 P52701 R510T 510 R T 0.37 Neutral MSH6 P52701 R510V 510 R V 0.566 Pathogenic MSH6 P52701 R510W 510 R W 0.716 Pathogenic MSH6 P52701 R510Y 510 R Y 0.612 Pathogenic MSH6 P52701 R511A 511 R A 0.388 Neutral MSH6 P52701 R511C 511 R C 0.61 Pathogenic MSH6 P52701 R511D 511 R D 0.596 Pathogenic MSH6 P52701 R511E 511 R E 0.506 Pathogenic MSH6 P52701 R511F 511 R F 0.876 Pathogenic MSH6 P52701 R511G 511 R G 0.182 Neutral MSH6 P52701 R511H 511 R H 0.472 Neutral MSH6 P52701 R511I 511 R I 0.878 Pathogenic MSH6 P52701 R511K 511 R K 0.606 Pathogenic MSH6 P52701 R511L 511 R L 0.846 Pathogenic MSH6 P52701 R511M 511 R M 0.626 Pathogenic MSH6 P52701 R511N 511 R N 0.49 Neutral MSH6 P52701 R511P 511 R P 0.798 Pathogenic MSH6 P52701 R511Q 511 R Q 0.566 Pathogenic MSH6 P52701 R511S 511 R S 0.216 Neutral MSH6 P52701 R511T 511 R T 0.5 Pathogenic MSH6 P52701 R511V 511 R V 0.784 Pathogenic MSH6 P52701 R511W 511 R W 0.868 Pathogenic MSH6 P52701 R511Y 511 R Y 0.858 Pathogenic MSH6 P52701 E512A 512 E A 0.594 Pathogenic MSH6 P52701 E512C 512 E C 0.762 Pathogenic MSH6 P52701 E512D 512 E D 0.894 Pathogenic MSH6 P52701 E512F 512 E F 0.962 Pathogenic MSH6 P52701 E512G 512 E G 0.26 Neutral MSH6 P52701 E512H 512 E H 0.732 Pathogenic MSH6 P52701 E512I 512 E I 0.982 Pathogenic MSH6 P52701 E512K 512 E K 0.494 Neutral MSH6 P52701 E512L 512 E L 0.974 Pathogenic MSH6 P52701 E512M 512 E M 0.906 Pathogenic MSH6 P52701 E512N 512 E N 0.782 Pathogenic MSH6 P52701 E512P 512 E P 0.936 Pathogenic MSH6 P52701 E512Q 512 E Q 0.37 Neutral MSH6 P52701 E512R 512 E R 0.932 Pathogenic MSH6 P52701 E512S 512 E S 0.898 Pathogenic MSH6 P52701 E512T 512 E T 0.848 Pathogenic MSH6 P52701 E512V 512 E V 0.918 Pathogenic MSH6 P52701 E512W 512 E W 0.98 Pathogenic MSH6 P52701 E512Y 512 E Y 0.96 Pathogenic MSH6 P52701 I513A 513 I A 0.202 Neutral MSH6 P52701 I513C 513 I C 0.608 Pathogenic MSH6 P52701 I513D 513 I D 0.76 Pathogenic MSH6 P52701 I513E 513 I E 0.764 Pathogenic MSH6 P52701 I513F 513 I F 0.966 Pathogenic MSH6 P52701 I513G 513 I G 0.808 Pathogenic MSH6 P52701 I513H 513 I H 0.84 Pathogenic MSH6 P52701 I513K 513 I K 0.852 Pathogenic MSH6 P52701 I513L 513 I L 0.108 Neutral MSH6 P52701 I513M 513 I M 0.688 Pathogenic MSH6 P52701 I513N 513 I N 0.786 Pathogenic MSH6 P52701 I513P 513 I P 0.944 Pathogenic MSH6 P52701 I513Q 513 I Q 0.54 Pathogenic MSH6 P52701 I513R 513 I R 0.88 Pathogenic MSH6 P52701 I513S 513 I S 0.626 Pathogenic MSH6 P52701 I513T 513 I T 0.364 Neutral MSH6 P52701 I513V 513 I V 0.116 Neutral MSH6 P52701 I513W 513 I W 0.988 Pathogenic MSH6 P52701 I513Y 513 I Y 0.984 Pathogenic MSH6 P52701 C514A 514 C A 0.128 Neutral MSH6 P52701 C514D 514 C D 0.922 Pathogenic MSH6 P52701 C514E 514 C E 0.886 Pathogenic MSH6 P52701 C514F 514 C F 0.904 Pathogenic MSH6 P52701 C514G 514 C G 0.202 Neutral MSH6 P52701 C514H 514 C H 0.888 Pathogenic MSH6 P52701 C514I 514 C I 0.846 Pathogenic MSH6 P52701 C514K 514 C K 0.878 Pathogenic MSH6 P52701 C514L 514 C L 0.976 Pathogenic MSH6 P52701 C514M 514 C M 0.796 Pathogenic MSH6 P52701 C514N 514 C N 0.75 Pathogenic MSH6 P52701 C514P 514 C P 0.966 Pathogenic MSH6 P52701 C514Q 514 C Q 0.702 Pathogenic MSH6 P52701 C514R 514 C R 0.996 Pathogenic MSH6 P52701 C514S 514 C S 0.092 Neutral MSH6 P52701 C514T 514 C T 0.122 Neutral MSH6 P52701 C514V 514 C V 0.49 Neutral MSH6 P52701 C514W 514 C W 0.996 Pathogenic MSH6 P52701 C514Y 514 C Y 0.99 Pathogenic MSH6 P52701 R515A 515 R A 0.11 Neutral MSH6 P52701 R515C 515 R C 0.06 Neutral MSH6 P52701 R515D 515 R D 0.64 Pathogenic MSH6 P52701 R515E 515 R E 0.56 Pathogenic MSH6 P52701 R515F 515 R F 0.934 Pathogenic MSH6 P52701 R515G 515 R G 0.076 Neutral MSH6 P52701 R515H 515 R H 0.426 Neutral MSH6 P52701 R515I 515 R I 0.902 Pathogenic MSH6 P52701 R515K 515 R K 0.534 Pathogenic MSH6 P52701 R515L 515 R L 0.884 Pathogenic MSH6 P52701 R515M 515 R M 0.68 Pathogenic MSH6 P52701 R515N 515 R N 0.032 Neutral MSH6 P52701 R515P 515 R P 0.844 Pathogenic MSH6 P52701 R515Q 515 R Q 0.016 Neutral MSH6 P52701 R515S 515 R S 0.058 Neutral MSH6 P52701 R515T 515 R T 0.182 Neutral MSH6 P52701 R515V 515 R V 0.826 Pathogenic MSH6 P52701 R515W 515 R W 0.914 Pathogenic MSH6 P52701 R515Y 515 R Y 0.894 Pathogenic MSH6 P52701 I516A 516 I A 0.462 Neutral MSH6 P52701 I516C 516 I C 0.602 Pathogenic MSH6 P52701 I516D 516 I D 0.744 Pathogenic MSH6 P52701 I516E 516 I E 0.754 Pathogenic MSH6 P52701 I516F 516 I F 0.962 Pathogenic MSH6 P52701 I516G 516 I G 0.792 Pathogenic MSH6 P52701 I516H 516 I H 0.848 Pathogenic MSH6 P52701 I516K 516 I K 0.846 Pathogenic MSH6 P52701 I516L 516 I L 0.102 Neutral MSH6 P52701 I516M 516 I M 0.188 Neutral MSH6 P52701 I516N 516 I N 0.77 Pathogenic MSH6 P52701 I516P 516 I P 0.926 Pathogenic MSH6 P52701 I516Q 516 I Q 0.784 Pathogenic MSH6 P52701 I516R 516 I R 0.668 Pathogenic MSH6 P52701 I516S 516 I S 0.61 Pathogenic MSH6 P52701 I516T 516 I T 0.158 Neutral MSH6 P52701 I516V 516 I V 0.246 Neutral MSH6 P52701 I516W 516 I W 0.986 Pathogenic MSH6 P52701 I516Y 516 I Y 0.976 Pathogenic MSH6 P52701 I517A 517 I A 0.134 Neutral MSH6 P52701 I517C 517 I C 0.436 Neutral MSH6 P52701 I517D 517 I D 0.63 Pathogenic MSH6 P52701 I517E 517 I E 0.614 Pathogenic MSH6 P52701 I517F 517 I F 0.54 Pathogenic MSH6 P52701 I517G 517 I G 0.598 Pathogenic MSH6 P52701 I517H 517 I H 0.512 Pathogenic MSH6 P52701 I517K 517 I K 0.628 Pathogenic MSH6 P52701 I517L 517 I L 0.038 Neutral MSH6 P52701 I517M 517 I M 0.354 Neutral MSH6 P52701 I517N 517 I N 0.672 Pathogenic MSH6 P52701 I517P 517 I P 0.762 Pathogenic MSH6 P52701 I517Q 517 I Q 0.264 Neutral MSH6 P52701 I517R 517 I R 0.828 Pathogenic MSH6 P52701 I517S 517 I S 0.096 Neutral MSH6 P52701 I517T 517 I T 0.018 Neutral MSH6 P52701 I517V 517 I V 0.002 Neutral MSH6 P52701 I517W 517 I W 0.882 Pathogenic MSH6 P52701 I517Y 517 I Y 0.878 Pathogenic MSH6 P52701 T518A 518 T A 0.696 Pathogenic MSH6 P52701 T518C 518 T C 0.93 Pathogenic MSH6 P52701 T518D 518 T D 0.31 Neutral MSH6 P52701 T518E 518 T E 0.948 Pathogenic MSH6 P52701 T518F 518 T F 0.948 Pathogenic MSH6 P52701 T518G 518 T G 0.73 Pathogenic MSH6 P52701 T518H 518 T H 0.914 Pathogenic MSH6 P52701 T518I 518 T I 0.95 Pathogenic MSH6 P52701 T518K 518 T K 0.938 Pathogenic MSH6 P52701 T518L 518 T L 0.396 Neutral MSH6 P52701 T518M 518 T M 0.984 Pathogenic MSH6 P52701 T518N 518 T N 0.208 Neutral MSH6 P52701 T518P 518 T P 0.958 Pathogenic MSH6 P52701 T518Q 518 T Q 0.878 Pathogenic MSH6 P52701 T518R 518 T R 0.99 Pathogenic MSH6 P52701 T518S 518 T S 0.152 Neutral MSH6 P52701 T518V 518 T V 0.354 Neutral MSH6 P52701 T518W 518 T W 0.988 Pathogenic MSH6 P52701 T518Y 518 T Y 0.988 Pathogenic MSH6 P52701 K519A 519 K A 0.07 Neutral MSH6 P52701 K519C 519 K C 0.16 Neutral MSH6 P52701 K519D 519 K D 0.256 Neutral MSH6 P52701 K519E 519 K E 0.156 Neutral MSH6 P52701 K519F 519 K F 0.826 Pathogenic MSH6 P52701 K519G 519 K G 0.102 Neutral MSH6 P52701 K519H 519 K H 0.332 Neutral MSH6 P52701 K519I 519 K I 0.13 Neutral MSH6 P52701 K519L 519 K L 0.418 Neutral MSH6 P52701 K519M 519 K M 0.586 Pathogenic MSH6 P52701 K519N 519 K N 0.03 Neutral MSH6 P52701 K519P 519 K P 0.086 Neutral MSH6 P52701 K519Q 519 K Q 0.034 Neutral MSH6 P52701 K519R 519 K R 0.028 Neutral MSH6 P52701 K519S 519 K S 0.026 Neutral MSH6 P52701 K519T 519 K T 0.202 Neutral MSH6 P52701 K519V 519 K V 0.424 Neutral MSH6 P52701 K519W 519 K W 0.976 Pathogenic MSH6 P52701 K519Y 519 K Y 0.924 Pathogenic MSH6 P52701 E52A 52 E A 0.212 Neutral MSH6 P52701 E52C 52 E C 0.068 Neutral MSH6 P52701 E52D 52 E D 0.082 Neutral MSH6 P52701 E52F 52 E F 0.312 Neutral MSH6 P52701 E52G 52 E G 0.002 Neutral MSH6 P52701 E52H 52 E H 0.104 Neutral MSH6 P52701 E52I 52 E I 0.284 Neutral MSH6 P52701 E52K 52 E K 0.162 Neutral MSH6 P52701 E52L 52 E L 0.286 Neutral MSH6 P52701 E52M 52 E M 0.164 Neutral MSH6 P52701 E52N 52 E N 0.04 Neutral MSH6 P52701 E52P 52 E P 0.044 Neutral MSH6 P52701 E52Q 52 E Q 0 Neutral MSH6 P52701 E52R 52 E R 0.03 Neutral MSH6 P52701 E52S 52 E S 0.014 Neutral MSH6 P52701 E52T 52 E T 0.14 Neutral MSH6 P52701 E52V 52 E V 0.25 Neutral MSH6 P52701 E52W 52 E W 0.43 Neutral MSH6 P52701 E52Y 52 E Y 0.338 Neutral MSH6 P52701 G520A 520 G A 0.532 Pathogenic MSH6 P52701 G520C 520 G C 0.946 Pathogenic MSH6 P52701 G520D 520 G D 0.998 Pathogenic MSH6 P52701 G520E 520 G E 0.986 Pathogenic MSH6 P52701 G520F 520 G F 0.98 Pathogenic MSH6 P52701 G520H 520 G H 0.984 Pathogenic MSH6 P52701 G520I 520 G I 0.97 Pathogenic MSH6 P52701 G520K 520 G K 0.984 Pathogenic MSH6 P52701 G520L 520 G L 0.98 Pathogenic MSH6 P52701 G520M 520 G M 0.992 Pathogenic MSH6 P52701 G520N 520 G N 0.984 Pathogenic MSH6 P52701 G520P 520 G P 0.962 Pathogenic MSH6 P52701 G520Q 520 G Q 0.992 Pathogenic MSH6 P52701 G520R 520 G R 0.998 Pathogenic MSH6 P52701 G520S 520 G S 0.824 Pathogenic MSH6 P52701 G520T 520 G T 0.838 Pathogenic MSH6 P52701 G520V 520 G V 0.982 Pathogenic MSH6 P52701 G520W 520 G W 0.976 Pathogenic MSH6 P52701 G520Y 520 G Y 0.956 Pathogenic MSH6 P52701 T521A 521 T A 0.408 Neutral MSH6 P52701 T521C 521 T C 0.384 Neutral MSH6 P52701 T521D 521 T D 0.47 Neutral MSH6 P52701 T521E 521 T E 0.56 Pathogenic MSH6 P52701 T521F 521 T F 0.446 Neutral MSH6 P52701 T521G 521 T G 0.272 Neutral MSH6 P52701 T521H 521 T H 0.528 Pathogenic MSH6 P52701 T521I 521 T I 0.508 Pathogenic MSH6 P52701 T521K 521 T K 0.494 Neutral MSH6 P52701 T521L 521 T L 0.078 Neutral MSH6 P52701 T521M 521 T M 0.394 Neutral MSH6 P52701 T521N 521 T N 0.282 Neutral MSH6 P52701 T521P 521 T P 0.6 Pathogenic MSH6 P52701 T521Q 521 T Q 0.03 Neutral MSH6 P52701 T521R 521 T R 0.772 Pathogenic MSH6 P52701 T521S 521 T S 0.026 Neutral MSH6 P52701 T521V 521 T V 0.07 Neutral MSH6 P52701 T521W 521 T W 0.914 Pathogenic MSH6 P52701 T521Y 521 T Y 0.558 Pathogenic MSH6 P52701 Q522A 522 Q A 0.17 Neutral MSH6 P52701 Q522C 522 Q C 0.344 Neutral MSH6 P52701 Q522D 522 Q D 0.49 Neutral MSH6 P52701 Q522E 522 Q E 0.56 Pathogenic MSH6 P52701 Q522F 522 Q F 0.858 Pathogenic MSH6 P52701 Q522G 522 Q G 0.45 Neutral MSH6 P52701 Q522H 522 Q H 0.782 Pathogenic MSH6 P52701 Q522I 522 Q I 0.372 Neutral MSH6 P52701 Q522K 522 Q K 0.084 Neutral MSH6 P52701 Q522L 522 Q L 0.196 Neutral MSH6 P52701 Q522M 522 Q M 0.732 Pathogenic MSH6 P52701 Q522N 522 Q N 0.534 Pathogenic MSH6 P52701 Q522P 522 Q P 0.84 Pathogenic MSH6 P52701 Q522R 522 Q R 0.09 Neutral MSH6 P52701 Q522S 522 Q S 0.666 Pathogenic MSH6 P52701 Q522T 522 Q T 0.034 Neutral MSH6 P52701 Q522V 522 Q V 0.096 Neutral MSH6 P52701 Q522W 522 Q W 0.93 Pathogenic MSH6 P52701 Q522Y 522 Q Y 0.89 Pathogenic MSH6 P52701 T523A 523 T A 0.118 Neutral MSH6 P52701 T523C 523 T C 0.574 Pathogenic MSH6 P52701 T523D 523 T D 0.09 Neutral MSH6 P52701 T523E 523 T E 0.152 Neutral MSH6 P52701 T523F 523 T F 0.782 Pathogenic MSH6 P52701 T523G 523 T G 0.116 Neutral MSH6 P52701 T523H 523 T H 0.638 Pathogenic MSH6 P52701 T523I 523 T I 0.208 Neutral MSH6 P52701 T523K 523 T K 0.61 Pathogenic MSH6 P52701 T523L 523 T L 0.096 Neutral MSH6 P52701 T523M 523 T M 0.536 Pathogenic MSH6 P52701 T523N 523 T N 0.024 Neutral MSH6 P52701 T523P 523 T P 0.686 Pathogenic MSH6 P52701 T523Q 523 T Q 0.042 Neutral MSH6 P52701 T523R 523 T R 0.592 Pathogenic MSH6 P52701 T523S 523 T S 0.396 Neutral MSH6 P52701 T523V 523 T V 0.18 Neutral MSH6 P52701 T523W 523 T W 0.952 Pathogenic MSH6 P52701 T523Y 523 T Y 0.948 Pathogenic MSH6 P52701 Y524A 524 Y A 0.124 Neutral MSH6 P52701 Y524C 524 Y C 0.144 Neutral MSH6 P52701 Y524D 524 Y D 0.096 Neutral MSH6 P52701 Y524E 524 Y E 0.082 Neutral MSH6 P52701 Y524F 524 Y F 0.034 Neutral MSH6 P52701 Y524G 524 Y G 0.182 Neutral MSH6 P52701 Y524H 524 Y H 0.048 Neutral MSH6 P52701 Y524I 524 Y I 0.294 Neutral MSH6 P52701 Y524K 524 Y K 0.444 Neutral MSH6 P52701 Y524L 524 Y L 0.17 Neutral MSH6 P52701 Y524M 524 Y M 0.244 Neutral MSH6 P52701 Y524N 524 Y N 0.342 Neutral MSH6 P52701 Y524P 524 Y P 0.378 Neutral MSH6 P52701 Y524Q 524 Y Q 0.336 Neutral MSH6 P52701 Y524R 524 Y R 0.506 Pathogenic MSH6 P52701 Y524S 524 Y S 0.176 Neutral MSH6 P52701 Y524T 524 Y T 0.144 Neutral MSH6 P52701 Y524V 524 Y V 0.046 Neutral MSH6 P52701 Y524W 524 Y W 0.468 Neutral MSH6 P52701 S525A 525 S A 0.086 Neutral MSH6 P52701 S525C 525 S C 0.1 Neutral MSH6 P52701 S525D 525 S D 0.184 Neutral MSH6 P52701 S525E 525 S E 0.448 Neutral MSH6 P52701 S525F 525 S F 0.854 Pathogenic MSH6 P52701 S525G 525 S G 0.048 Neutral MSH6 P52701 S525H 525 S H 0.672 Pathogenic MSH6 P52701 S525I 525 S I 0.364 Neutral MSH6 P52701 S525K 525 S K 0.486 Neutral MSH6 P52701 S525L 525 S L 0.576 Pathogenic MSH6 P52701 S525M 525 S M 0.956 Pathogenic MSH6 P52701 S525N 525 S N 0.062 Neutral MSH6 P52701 S525P 525 S P 0.208 Neutral MSH6 P52701 S525Q 525 S Q 0.47 Neutral MSH6 P52701 S525R 525 S R 0.678 Pathogenic MSH6 P52701 S525T 525 S T 0.1 Neutral MSH6 P52701 S525V 525 S V 0.124 Neutral MSH6 P52701 S525W 525 S W 0.94 Pathogenic MSH6 P52701 S525Y 525 S Y 0.92 Pathogenic MSH6 P52701 V526A 526 V A 0.188 Neutral MSH6 P52701 V526C 526 V C 0.284 Neutral MSH6 P52701 V526D 526 V D 0.054 Neutral MSH6 P52701 V526E 526 V E 0.094 Neutral MSH6 P52701 V526F 526 V F 0.422 Neutral MSH6 P52701 V526G 526 V G 0.564 Pathogenic MSH6 P52701 V526H 526 V H 0.164 Neutral MSH6 P52701 V526I 526 V I 0.052 Neutral MSH6 P52701 V526K 526 V K 0.678 Pathogenic MSH6 P52701 V526L 526 V L 0.056 Neutral MSH6 P52701 V526M 526 V M 0.05 Neutral MSH6 P52701 V526N 526 V N 0.082 Neutral MSH6 P52701 V526P 526 V P 0.724 Pathogenic MSH6 P52701 V526Q 526 V Q 0.3 Neutral MSH6 P52701 V526R 526 V R 0.786 Pathogenic MSH6 P52701 V526S 526 V S 0.04 Neutral MSH6 P52701 V526T 526 V T 0.028 Neutral MSH6 P52701 V526W 526 V W 0.772 Pathogenic MSH6 P52701 V526Y 526 V Y 0.544 Pathogenic MSH6 P52701 L527A 527 L A 0.04 Neutral MSH6 P52701 L527C 527 L C 0.164 Neutral MSH6 P52701 L527D 527 L D 0.22 Neutral MSH6 P52701 L527E 527 L E 0.414 Neutral MSH6 P52701 L527F 527 L F 0.49 Neutral MSH6 P52701 L527G 527 L G 0.12 Neutral MSH6 P52701 L527H 527 L H 0.082 Neutral MSH6 P52701 L527I 527 L I 0.046 Neutral MSH6 P52701 L527K 527 L K 0.444 Neutral MSH6 P52701 L527M 527 L M 0.018 Neutral MSH6 P52701 L527N 527 L N 0.216 Neutral MSH6 P52701 L527P 527 L P 0.324 Neutral MSH6 P52701 L527Q 527 L Q 0.192 Neutral MSH6 P52701 L527R 527 L R 0.592 Pathogenic MSH6 P52701 L527S 527 L S 0.046 Neutral MSH6 P52701 L527T 527 L T 0.034 Neutral MSH6 P52701 L527V 527 L V 0.034 Neutral MSH6 P52701 L527W 527 L W 0.578 Pathogenic MSH6 P52701 L527Y 527 L Y 0.806 Pathogenic MSH6 P52701 E528A 528 E A 0.192 Neutral MSH6 P52701 E528C 528 E C 0.394 Neutral MSH6 P52701 E528D 528 E D 0.018 Neutral MSH6 P52701 E528F 528 E F 0.802 Pathogenic MSH6 P52701 E528G 528 E G 0.028 Neutral MSH6 P52701 E528H 528 E H 0.642 Pathogenic MSH6 P52701 E528I 528 E I 0.576 Pathogenic MSH6 P52701 E528K 528 E K 0.664 Pathogenic MSH6 P52701 E528L 528 E L 0.104 Neutral MSH6 P52701 E528M 528 E M 0.666 Pathogenic MSH6 P52701 E528N 528 E N 0.178 Neutral MSH6 P52701 E528P 528 E P 0.106 Neutral MSH6 P52701 E528Q 528 E Q 0.012 Neutral MSH6 P52701 E528R 528 E R 0.374 Neutral MSH6 P52701 E528S 528 E S 0.038 Neutral MSH6 P52701 E528T 528 E T 0.04 Neutral MSH6 P52701 E528V 528 E V 0.462 Neutral MSH6 P52701 E528W 528 E W 0.922 Pathogenic MSH6 P52701 E528Y 528 E Y 0.34 Neutral MSH6 P52701 G529A 529 G A 0.088 Neutral MSH6 P52701 G529C 529 G C 0.514 Pathogenic MSH6 P52701 G529D 529 G D 0.452 Neutral MSH6 P52701 G529E 529 G E 0.548 Pathogenic MSH6 P52701 G529F 529 G F 0.954 Pathogenic MSH6 P52701 G529H 529 G H 0.674 Pathogenic MSH6 P52701 G529I 529 G I 0.94 Pathogenic MSH6 P52701 G529K 529 G K 0.942 Pathogenic MSH6 P52701 G529L 529 G L 0.792 Pathogenic MSH6 P52701 G529M 529 G M 0.928 Pathogenic MSH6 P52701 G529N 529 G N 0.462 Neutral MSH6 P52701 G529P 529 G P 0.93 Pathogenic MSH6 P52701 G529Q 529 G Q 0.546 Pathogenic MSH6 P52701 G529R 529 G R 0.77 Pathogenic MSH6 P52701 G529S 529 G S 0.094 Neutral MSH6 P52701 G529T 529 G T 0.576 Pathogenic MSH6 P52701 G529V 529 G V 0.95 Pathogenic MSH6 P52701 G529W 529 G W 0.952 Pathogenic MSH6 P52701 G529Y 529 G Y 0.934 Pathogenic MSH6 P52701 A53C 53 A C 0.182 Neutral MSH6 P52701 A53D 53 A D 0.266 Neutral MSH6 P52701 A53E 53 A E 0.306 Neutral MSH6 P52701 A53F 53 A F 0.468 Neutral MSH6 P52701 A53G 53 A G 0.006 Neutral MSH6 P52701 A53H 53 A H 0.26 Neutral MSH6 P52701 A53I 53 A I 0.406 Neutral MSH6 P52701 A53K 53 A K 0.29 Neutral MSH6 P52701 A53L 53 A L 0.4 Neutral MSH6 P52701 A53M 53 A M 0.29 Neutral MSH6 P52701 A53N 53 A N 0.296 Neutral MSH6 P52701 A53P 53 A P 0.3 Neutral MSH6 P52701 A53Q 53 A Q 0.246 Neutral MSH6 P52701 A53R 53 A R 0.318 Neutral MSH6 P52701 A53S 53 A S 0.008 Neutral MSH6 P52701 A53T 53 A T 0.172 Neutral MSH6 P52701 A53V 53 A V 0.202 Neutral MSH6 P52701 A53W 53 A W 0.504 Pathogenic MSH6 P52701 A53Y 53 A Y 0.5 Pathogenic MSH6 P52701 D530A 530 D A 0.026 Neutral MSH6 P52701 D530C 530 D C 0.26 Neutral MSH6 P52701 D530E 530 D E 0.018 Neutral MSH6 P52701 D530F 530 D F 0.678 Pathogenic MSH6 P52701 D530G 530 D G 0.026 Neutral MSH6 P52701 D530H 530 D H 0.032 Neutral MSH6 P52701 D530I 530 D I 0.456 Neutral MSH6 P52701 D530K 530 D K 0.18 Neutral MSH6 P52701 D530L 530 D L 0.21 Neutral MSH6 P52701 D530M 530 D M 0.34 Neutral MSH6 P52701 D530N 530 D N 0 Neutral MSH6 P52701 D530P 530 D P 0.066 Neutral MSH6 P52701 D530Q 530 D Q 0.116 Neutral MSH6 P52701 D530R 530 D R 0.328 Neutral MSH6 P52701 D530S 530 D S 0.114 Neutral MSH6 P52701 D530T 530 D T 0.28 Neutral MSH6 P52701 D530V 530 D V 0.442 Neutral MSH6 P52701 D530W 530 D W 0.75 Pathogenic MSH6 P52701 D530Y 530 D Y 0.526 Pathogenic MSH6 P52701 P531A 531 P A 0.04 Neutral MSH6 P52701 P531C 531 P C 0.04 Neutral MSH6 P52701 P531D 531 P D 0.024 Neutral MSH6 P52701 P531E 531 P E 0.086 Neutral MSH6 P52701 P531F 531 P F 0.376 Neutral MSH6 P52701 P531G 531 P G 0.016 Neutral MSH6 P52701 P531H 531 P H 0.34 Neutral MSH6 P52701 P531I 531 P I 0.054 Neutral MSH6 P52701 P531K 531 P K 0.356 Neutral MSH6 P52701 P531L 531 P L 0.05 Neutral MSH6 P52701 P531M 531 P M 0.38 Neutral MSH6 P52701 P531N 531 P N 0.01 Neutral MSH6 P52701 P531Q 531 P Q 0.082 Neutral MSH6 P52701 P531R 531 P R 0.43 Neutral MSH6 P52701 P531S 531 P S 0.008 Neutral MSH6 P52701 P531T 531 P T 0.022 Neutral MSH6 P52701 P531V 531 P V 0.152 Neutral MSH6 P52701 P531W 531 P W 0.61 Pathogenic MSH6 P52701 P531Y 531 P Y 0.362 Neutral MSH6 P52701 S532A 532 S A 0.012 Neutral MSH6 P52701 S532C 532 S C 0.038 Neutral MSH6 P52701 S532D 532 S D 0.006 Neutral MSH6 P52701 S532E 532 S E 0.23 Neutral MSH6 P52701 S532F 532 S F 0.514 Pathogenic MSH6 P52701 S532G 532 S G 0.004 Neutral MSH6 P52701 S532H 532 S H 0.288 Neutral MSH6 P52701 S532I 532 S I 0.22 Neutral MSH6 P52701 S532K 532 S K 0.246 Neutral MSH6 P52701 S532L 532 S L 0.054 Neutral MSH6 P52701 S532M 532 S M 0.616 Pathogenic MSH6 P52701 S532N 532 S N 0.062 Neutral MSH6 P52701 S532P 532 S P 0.068 Neutral MSH6 P52701 S532Q 532 S Q 0.278 Neutral MSH6 P52701 S532R 532 S R 0.35 Neutral MSH6 P52701 S532T 532 S T 0.02 Neutral MSH6 P52701 S532V 532 S V 0.046 Neutral MSH6 P52701 S532W 532 S W 0.734 Pathogenic MSH6 P52701 S532Y 532 S Y 0.69 Pathogenic MSH6 P52701 E533A 533 E A 0.196 Neutral MSH6 P52701 E533C 533 E C 0.114 Neutral MSH6 P52701 E533D 533 E D 0.002 Neutral MSH6 P52701 E533F 533 E F 0.43 Neutral MSH6 P52701 E533G 533 E G 0 Neutral MSH6 P52701 E533H 533 E H 0.132 Neutral MSH6 P52701 E533I 533 E I 0.462 Neutral MSH6 P52701 E533K 533 E K 0.008 Neutral MSH6 P52701 E533L 533 E L 0.46 Neutral MSH6 P52701 E533M 533 E M 0.292 Neutral MSH6 P52701 E533N 533 E N 0.002 Neutral MSH6 P52701 E533P 533 E P 0.07 Neutral MSH6 P52701 E533Q 533 E Q 0.086 Neutral MSH6 P52701 E533R 533 E R 0.07 Neutral MSH6 P52701 E533S 533 E S 0.018 Neutral MSH6 P52701 E533T 533 E T 0.014 Neutral MSH6 P52701 E533V 533 E V 0.39 Neutral MSH6 P52701 E533W 533 E W 0.696 Pathogenic MSH6 P52701 E533Y 533 E Y 0.58 Pathogenic MSH6 P52701 N534A 534 N A 0.004 Neutral MSH6 P52701 N534C 534 N C 0.092 Neutral MSH6 P52701 N534D 534 N D 0.028 Neutral MSH6 P52701 N534E 534 N E 0.04 Neutral MSH6 P52701 N534F 534 N F 0.34 Neutral MSH6 P52701 N534G 534 N G 0.16 Neutral MSH6 P52701 N534H 534 N H 0.07 Neutral MSH6 P52701 N534I 534 N I 0.266 Neutral MSH6 P52701 N534K 534 N K 0.038 Neutral MSH6 P52701 N534L 534 N L 0.172 Neutral MSH6 P52701 N534M 534 N M 0.22 Neutral MSH6 P52701 N534P 534 N P 0.338 Neutral MSH6 P52701 N534Q 534 N Q 0.114 Neutral MSH6 P52701 N534R 534 N R 0.148 Neutral MSH6 P52701 N534S 534 N S 0 Neutral MSH6 P52701 N534T 534 N T 0.006 Neutral MSH6 P52701 N534V 534 N V 0.026 Neutral MSH6 P52701 N534W 534 N W 0.446 Neutral MSH6 P52701 N534Y 534 N Y 0.402 Neutral MSH6 P52701 Y535A 535 Y A 0.126 Neutral MSH6 P52701 Y535C 535 Y C 0.15 Neutral MSH6 P52701 Y535D 535 Y D 0.242 Neutral MSH6 P52701 Y535E 535 Y E 0.04 Neutral MSH6 P52701 Y535F 535 Y F 0.058 Neutral MSH6 P52701 Y535G 535 Y G 0.182 Neutral MSH6 P52701 Y535H 535 Y H 0.006 Neutral MSH6 P52701 Y535I 535 Y I 0.152 Neutral MSH6 P52701 Y535K 535 Y K 0.254 Neutral MSH6 P52701 Y535L 535 Y L 0.014 Neutral MSH6 P52701 Y535M 535 Y M 0.014 Neutral MSH6 P52701 Y535N 535 Y N 0.078 Neutral MSH6 P52701 Y535P 535 Y P 0.122 Neutral MSH6 P52701 Y535Q 535 Y Q 0.07 Neutral MSH6 P52701 Y535R 535 Y R 0.112 Neutral MSH6 P52701 Y535S 535 Y S 0.106 Neutral MSH6 P52701 Y535T 535 Y T 0.148 Neutral MSH6 P52701 Y535V 535 Y V 0.214 Neutral MSH6 P52701 Y535W 535 Y W 0.112 Neutral MSH6 P52701 S536A 536 S A 0.102 Neutral MSH6 P52701 S536C 536 S C 0.376 Neutral MSH6 P52701 S536D 536 S D 0.454 Neutral MSH6 P52701 S536E 536 S E 0.612 Pathogenic MSH6 P52701 S536F 536 S F 0.844 Pathogenic MSH6 P52701 S536G 536 S G 0.276 Neutral MSH6 P52701 S536H 536 S H 0.67 Pathogenic MSH6 P52701 S536I 536 S I 0.552 Pathogenic MSH6 P52701 S536K 536 S K 0.694 Pathogenic MSH6 P52701 S536L 536 S L 0.53 Pathogenic MSH6 P52701 S536M 536 S M 0.948 Pathogenic MSH6 P52701 S536N 536 S N 0.064 Neutral MSH6 P52701 S536P 536 S P 0.22 Neutral MSH6 P52701 S536Q 536 S Q 0.566 Pathogenic MSH6 P52701 S536R 536 S R 0.766 Pathogenic MSH6 P52701 S536T 536 S T 0.118 Neutral MSH6 P52701 S536V 536 S V 0.5 Pathogenic MSH6 P52701 S536W 536 S W 0.934 Pathogenic MSH6 P52701 S536Y 536 S Y 0.914 Pathogenic MSH6 P52701 K537A 537 K A 0.04 Neutral MSH6 P52701 K537C 537 K C 0.13 Neutral MSH6 P52701 K537D 537 K D 0.026 Neutral MSH6 P52701 K537E 537 K E 0.176 Neutral MSH6 P52701 K537F 537 K F 0.522 Pathogenic MSH6 P52701 K537G 537 K G 0.06 Neutral MSH6 P52701 K537H 537 K H 0.11 Neutral MSH6 P52701 K537I 537 K I 0.298 Neutral MSH6 P52701 K537L 537 K L 0.272 Neutral MSH6 P52701 K537M 537 K M 0.342 Neutral MSH6 P52701 K537N 537 K N 0.03 Neutral MSH6 P52701 K537P 537 K P 0.552 Pathogenic MSH6 P52701 K537Q 537 K Q 0.028 Neutral MSH6 P52701 K537R 537 K R 0.008 Neutral MSH6 P52701 K537S 537 K S 0.022 Neutral MSH6 P52701 K537T 537 K T 0.026 Neutral MSH6 P52701 K537V 537 K V 0.284 Neutral MSH6 P52701 K537W 537 K W 0.794 Pathogenic MSH6 P52701 K537Y 537 K Y 0.69 Pathogenic MSH6 P52701 Y538A 538 Y A 0.2 Neutral MSH6 P52701 Y538C 538 Y C 0.542 Pathogenic MSH6 P52701 Y538D 538 Y D 0.788 Pathogenic MSH6 P52701 Y538E 538 Y E 0.71 Pathogenic MSH6 P52701 Y538F 538 Y F 0.068 Neutral MSH6 P52701 Y538G 538 Y G 0.236 Neutral MSH6 P52701 Y538H 538 Y H 0.09 Neutral MSH6 P52701 Y538I 538 Y I 0.258 Neutral MSH6 P52701 Y538K 538 Y K 0.418 Neutral MSH6 P52701 Y538L 538 Y L 0.146 Neutral MSH6 P52701 Y538M 538 Y M 0.272 Neutral MSH6 P52701 Y538N 538 Y N 0.336 Neutral MSH6 P52701 Y538P 538 Y P 0.19 Neutral MSH6 P52701 Y538Q 538 Y Q 0.53 Pathogenic MSH6 P52701 Y538R 538 Y R 0.746 Pathogenic MSH6 P52701 Y538S 538 Y S 0.376 Neutral MSH6 P52701 Y538T 538 Y T 0.534 Pathogenic MSH6 P52701 Y538V 538 Y V 0.38 Neutral MSH6 P52701 Y538W 538 Y W 0.79 Pathogenic MSH6 P52701 L539A 539 L A 0.558 Pathogenic MSH6 P52701 L539C 539 L C 0.064 Neutral MSH6 P52701 L539D 539 L D 0.896 Pathogenic MSH6 P52701 L539E 539 L E 0.876 Pathogenic MSH6 P52701 L539F 539 L F 0.784 Pathogenic MSH6 P52701 L539G 539 L G 0.8 Pathogenic MSH6 P52701 L539H 539 L H 0.794 Pathogenic MSH6 P52701 L539I 539 L I 0.174 Neutral MSH6 P52701 L539K 539 L K 0.744 Pathogenic MSH6 P52701 L539M 539 L M 0.164 Neutral MSH6 P52701 L539N 539 L N 0.476 Neutral MSH6 P52701 L539P 539 L P 0.998 Pathogenic MSH6 P52701 L539Q 539 L Q 0.608 Pathogenic MSH6 P52701 L539R 539 L R 0.99 Pathogenic MSH6 P52701 L539S 539 L S 0.184 Neutral MSH6 P52701 L539T 539 L T 0.584 Pathogenic MSH6 P52701 L539V 539 L V 0.314 Neutral MSH6 P52701 L539W 539 L W 0.94 Pathogenic MSH6 P52701 L539Y 539 L Y 0.83 Pathogenic MSH6 P52701 G54A 54 G A 0.01 Neutral 2 MSH6 P52701 G54C 54 G C 0.14 Neutral MSH6 P52701 G54D 54 G D 0.118 Neutral MSH6 P52701 G54E 54 G E 0.19 Neutral MSH6 P52701 G54F 54 G F 0.498 Neutral MSH6 P52701 G54H 54 G H 0.442 Neutral MSH6 P52701 G54I 54 G I 0.412 Neutral MSH6 P52701 G54K 54 G K 0.358 Neutral MSH6 P52701 G54L 54 G L 0.412 Neutral MSH6 P52701 G54M 54 G M 0.422 Neutral MSH6 P52701 G54N 54 G N 0.172 Neutral MSH6 P52701 G54P 54 G P 0.442 Neutral MSH6 P52701 G54Q 54 G Q 0.19 Neutral MSH6 P52701 G54R 54 G R 0.324 Neutral MSH6 P52701 G54S 54 G S 0.018 Neutral MSH6 P52701 G54T 54 G T 0.274 Neutral MSH6 P52701 G54V 54 G V 0.39 Neutral MSH6 P52701 G54W 54 G W 0.498 Neutral MSH6 P52701 G54Y 54 G Y 0.5 Pathogenic MSH6 P52701 L540A 540 L A 0.04 Neutral MSH6 P52701 L540C 540 L C 0.414 Neutral MSH6 P52701 L540D 540 L D 0.662 Pathogenic MSH6 P52701 L540E 540 L E 0.414 Neutral MSH6 P52701 L540F 540 L F 0.266 Neutral MSH6 P52701 L540G 540 L G 0.57 Pathogenic MSH6 P52701 L540H 540 L H 0.082 Neutral MSH6 P52701 L540I 540 L I 0.06 Neutral MSH6 P52701 L540K 540 L K 0.444 Neutral MSH6 P52701 L540M 540 L M 0.012 Neutral MSH6 P52701 L540N 540 L N 0.608 Pathogenic MSH6 P52701 L540P 540 L P 0.896 Pathogenic MSH6 P52701 L540Q 540 L Q 0.192 Neutral MSH6 P52701 L540R 540 L R 0.858 Pathogenic MSH6 P52701 L540S 540 L S 0.334 Neutral MSH6 P52701 L540T 540 L T 0.336 Neutral MSH6 P52701 L540V 540 L V 0 Neutral MSH6 P52701 L540W 540 L W 0.82 Pathogenic MSH6 P52701 L540Y 540 L Y 0.604 Pathogenic MSH6 P52701 S541A 541 S A 0.138 Neutral MSH6 P52701 S541C 541 S C 0.218 Neutral MSH6 P52701 S541D 541 S D 0.804 Pathogenic MSH6 P52701 S541E 541 S E 0.676 Pathogenic MSH6 P52701 S541F 541 S F 0.976 Pathogenic MSH6 P52701 S541G 541 S G 0.152 Neutral MSH6 P52701 S541H 541 S H 0.924 Pathogenic MSH6 P52701 S541I 541 S I 0.772 Pathogenic MSH6 P52701 S541K 541 S K 0.666 Pathogenic MSH6 P52701 S541L 541 S L 0.882 Pathogenic MSH6 P52701 S541M 541 S M 0.998 Pathogenic MSH6 P52701 S541N 541 S N 0.766 Pathogenic MSH6 P52701 S541P 541 S P 0.918 Pathogenic MSH6 P52701 S541Q 541 S Q 0.87 Pathogenic MSH6 P52701 S541R 541 S R 0.93 Pathogenic MSH6 P52701 S541T 541 S T 0.402 Neutral MSH6 P52701 S541V 541 S V 0.52 Pathogenic MSH6 P52701 S541W 541 S W 0.984 Pathogenic MSH6 P52701 S541Y 541 S Y 0.98 Pathogenic MSH6 P52701 L542A 542 L A 0.57 Pathogenic MSH6 P52701 L542C 542 L C 0.694 Pathogenic MSH6 P52701 L542D 542 L D 0.532 Pathogenic MSH6 P52701 L542E 542 L E 0.192 Neutral MSH6 P52701 L542F 542 L F 0.478 Neutral MSH6 P52701 L542G 542 L G 0.814 Pathogenic MSH6 P52701 L542H 542 L H 0.342 Neutral MSH6 P52701 L542I 542 L I 0.152 Neutral MSH6 P52701 L542K 542 L K 0.732 Pathogenic MSH6 P52701 L542M 542 L M 0.452 Neutral MSH6 P52701 L542N 542 L N 0.788 Pathogenic MSH6 P52701 L542P 542 L P 0.986 Pathogenic MSH6 P52701 L542Q 542 L Q 0.622 Pathogenic MSH6 P52701 L542R 542 L R 0.998 Pathogenic MSH6 P52701 L542S 542 L S 0.608 Pathogenic MSH6 P52701 L542T 542 L T 0.582 Pathogenic MSH6 P52701 L542V 542 L V 0.1 Neutral MSH6 P52701 L542W 542 L W 0.91 Pathogenic MSH6 P52701 L542Y 542 L Y 0.87 Pathogenic MSH6 P52701 K543A 543 K A 0.11 Neutral MSH6 P52701 K543C 543 K C 0.104 Neutral MSH6 P52701 K543D 543 K D 0.206 Neutral MSH6 P52701 K543E 543 K E 0.234 Neutral MSH6 P52701 K543F 543 K F 0.514 Pathogenic MSH6 P52701 K543G 543 K G 0.328 Neutral MSH6 P52701 K543H 543 K H 0.642 Pathogenic MSH6 P52701 K543I 543 K I 0.296 Neutral MSH6 P52701 K543L 543 K L 0.68 Pathogenic MSH6 P52701 K543M 543 K M 0.25 Neutral MSH6 P52701 K543N 543 K N 0.618 Pathogenic MSH6 P52701 K543P 543 K P 0.842 Pathogenic MSH6 P52701 K543Q 543 K Q 0.674 Pathogenic MSH6 P52701 K543R 543 K R 0.166 Neutral MSH6 P52701 K543S 543 K S 0.14 Neutral MSH6 P52701 K543T 543 K T 0.13 Neutral MSH6 P52701 K543V 543 K V 0.214 Neutral MSH6 P52701 K543W 543 K W 0.878 Pathogenic MSH6 P52701 K543Y 543 K Y 0.916 Pathogenic MSH6 P52701 E544A 544 E A 0.81 Pathogenic MSH6 P52701 E544C 544 E C 0.764 Pathogenic MSH6 P52701 E544D 544 E D 0.502 Pathogenic MSH6 P52701 E544F 544 E F 0.96 Pathogenic MSH6 P52701 E544G 544 E G 0.26 Neutral MSH6 P52701 E544H 544 E H 0.744 Pathogenic MSH6 P52701 E544I 544 E I 0.984 Pathogenic MSH6 P52701 E544K 544 E K 0.914 Pathogenic MSH6 P52701 E544L 544 E L 0.814 Pathogenic MSH6 P52701 E544M 544 E M 0.91 Pathogenic MSH6 P52701 E544N 544 E N 0.782 Pathogenic MSH6 P52701 E544P 544 E P 0.938 Pathogenic MSH6 P52701 E544Q 544 E Q 0.418 Neutral MSH6 P52701 E544R 544 E R 0.934 Pathogenic MSH6 P52701 E544S 544 E S 0.48 Neutral MSH6 P52701 E544T 544 E T 0.524 Pathogenic MSH6 P52701 E544V 544 E V 0.76 Pathogenic MSH6 P52701 E544W 544 E W 0.978 Pathogenic MSH6 P52701 E544Y 544 E Y 0.958 Pathogenic MSH6 P52701 K545A 545 K A 0.062 Neutral MSH6 P52701 K545C 545 K C 0.178 Neutral MSH6 P52701 K545D 545 K D 0.048 Neutral MSH6 P52701 K545E 545 K E 0.048 Neutral MSH6 P52701 K545F 545 K F 0.104 Neutral MSH6 P52701 K545G 545 K G 0.084 Neutral MSH6 P52701 K545H 545 K H 0.004 Neutral MSH6 P52701 K545I 545 K I 0.116 Neutral MSH6 P52701 K545L 545 K L 0.214 Neutral MSH6 P52701 K545M 545 K M 0.598 Pathogenic MSH6 P52701 K545N 545 K N 0.024 Neutral MSH6 P52701 K545P 545 K P 0.798 Pathogenic MSH6 P52701 K545Q 545 K Q 0.024 Neutral MSH6 P52701 K545R 545 K R 0.01 Neutral MSH6 P52701 K545S 545 K S 0.022 Neutral MSH6 P52701 K545T 545 K T 0.036 Neutral MSH6 P52701 K545V 545 K V 0.112 Neutral MSH6 P52701 K545W 545 K W 0.948 Pathogenic MSH6 P52701 K545Y 545 K Y 0.576 Pathogenic MSH6 P52701 E546A 546 E A 0.066 Neutral MSH6 P52701 E546C 546 E C 0.012 Neutral MSH6 P52701 E546D 546 E D 0 Neutral MSH6 P52701 E546F 546 E F 0.054 Neutral MSH6 P52701 E546G 546 E G 0 Neutral MSH6 P52701 E546H 546 E H 0.016 Neutral MSH6 P52701 E546I 546 E I 0.12 Neutral MSH6 P52701 E546K 546 E K 0.002 Neutral MSH6 P52701 E546L 546 E L 0.042 Neutral MSH6 P52701 E546M 546 E M 0.018 Neutral MSH6 P52701 E546N 546 E N 0.002 Neutral MSH6 P52701 E546P 546 E P 0.042 Neutral MSH6 P52701 E546Q 546 E Q 0.012 Neutral MSH6 P52701 E546R 546 E R 0.046 Neutral MSH6 P52701 E546S 546 E S 0.014 Neutral MSH6 P52701 E546T 546 E T 0.02 Neutral MSH6 P52701 E546V 546 E V 0.032 Neutral MSH6 P52701 E546W 546 E W 0.43 Neutral MSH6 P52701 E546Y 546 E Y 0.194 Neutral MSH6 P52701 E547A 547 E A 0.066 Neutral MSH6 P52701 E547C 547 E C 0.012 Neutral MSH6 P52701 E547D 547 E D 0 Neutral MSH6 P52701 E547F 547 E F 0.29 Neutral MSH6 P52701 E547G 547 E G 0 Neutral MSH6 P52701 E547H 547 E H 0.04 Neutral MSH6 P52701 E547I 547 E I 0.138 Neutral MSH6 P52701 E547K 547 E K 0.068 Neutral MSH6 P52701 E547L 547 E L 0.048 Neutral MSH6 P52701 E547M 547 E M 0.08 Neutral MSH6 P52701 E547N 547 E N 0.002 Neutral MSH6 P52701 E547P 547 E P 0.05 Neutral MSH6 P52701 E547Q 547 E Q 0 Neutral MSH6 P52701 E547R 547 E R 0.01 Neutral MSH6 P52701 E547S 547 E S 0.17 Neutral MSH6 P52701 E547T 547 E T 0.014 Neutral MSH6 P52701 E547V 547 E V 0.038 Neutral MSH6 P52701 E547W 547 E W 0.498 Neutral MSH6 P52701 E547Y 547 E Y 0.326 Neutral MSH6 P52701 D548A 548 D A 0.072 Neutral MSH6 P52701 D548C 548 D C 0.156 Neutral MSH6 P52701 D548E 548 D E 0.014 Neutral MSH6 P52701 D548F 548 D F 0.322 Neutral MSH6 P52701 D548G 548 D G 0.018 Neutral MSH6 P52701 D548H 548 D H 0.096 Neutral MSH6 P52701 D548I 548 D I 0.232 Neutral MSH6 P52701 D548K 548 D K 0.212 Neutral MSH6 P52701 D548L 548 D L 0.036 Neutral MSH6 P52701 D548M 548 D M 0.206 Neutral MSH6 P52701 D548N 548 D N 0 Neutral MSH6 P52701 D548P 548 D P 0.154 Neutral MSH6 P52701 D548Q 548 D Q 0.174 Neutral MSH6 P52701 D548R 548 D R 0.164 Neutral MSH6 P52701 D548S 548 D S 0.002 Neutral MSH6 P52701 D548T 548 D T 0.162 Neutral MSH6 P52701 D548V 548 D V 0.07 Neutral MSH6 P52701 D548W 548 D W 0.484 Neutral MSH6 P52701 D548Y 548 D Y 0.45 Neutral MSH6 P52701 S549A 549 S A 0.012 Neutral MSH6 P52701 S549C 549 S C 0.022 Neutral MSH6 P52701 S549D 549 S D 0.008 Neutral MSH6 P52701 S549E 549 S E 0.162 Neutral MSH6 P52701 S549F 549 S F 0.358 Neutral MSH6 P52701 S549G 549 S G 0 Neutral MSH6 P52701 S549H 549 S H 0.306 Neutral MSH6 P52701 S549I 549 S I 0.058 Neutral MSH6 P52701 S549K 549 S K 0.19 Neutral MSH6 P52701 S549L 549 S L 0.104 Neutral MSH6 P52701 S549M 549 S M 0.436 Neutral MSH6 P52701 S549N 549 S N 0 Neutral MSH6 P52701 S549P 549 S P 0.076 Neutral MSH6 P52701 S549Q 549 S Q 0.198 Neutral MSH6 P52701 S549R 549 S R 0.164 Neutral MSH6 P52701 S549T 549 S T 0.024 Neutral MSH6 P52701 S549V 549 S V 0.14 Neutral MSH6 P52701 S549W 549 S W 0.574 Pathogenic MSH6 P52701 S549Y 549 S Y 0.532 Pathogenic MSH6 P52701 P55A 55 P A 0.176 Neutral MSH6 P52701 P55C 55 P C 0.148 Neutral MSH6 P52701 P55D 55 P D 0.05 Neutral MSH6 P52701 P55E 55 P E 0.214 Neutral MSH6 P52701 P55F 55 P F 0.272 Neutral MSH6 P52701 P55G 55 P G 0.092 Neutral MSH6 P52701 P55H 55 P H 0.266 Neutral MSH6 P52701 P55I 55 P I 0.104 Neutral MSH6 P52701 P55K 55 P K 0.1 Neutral MSH6 P52701 P55L 55 P L 0.108 Neutral MSH6 P52701 P55M 55 P M 0.22 Neutral MSH6 P52701 P55N 55 P N 0.068 Neutral MSH6 P52701 P55Q 55 P Q 0.06 Neutral MSH6 P52701 P55R 55 P R 0.202 Neutral MSH6 P52701 P55S 55 P S 0.002 Neutral MSH6 P52701 P55T 55 P T 0.084 Neutral MSH6 P52701 P55V 55 P V 0.13 Neutral MSH6 P52701 P55W 55 P W 0.39 Neutral MSH6 P52701 P55Y 55 P Y 0.32 Neutral MSH6 P52701 S550A 550 S A 0.012 Neutral MSH6 P52701 S550C 550 S C 0.036 Neutral MSH6 P52701 S550D 550 S D 0.034 Neutral MSH6 P52701 S550E 550 S E 0.194 Neutral MSH6 P52701 S550F 550 S F 0.432 Neutral MSH6 P52701 S550G 550 S G 0.004 Neutral MSH6 P52701 S550H 550 S H 0.368 Neutral MSH6 P52701 S550I 550 S I 0.192 Neutral MSH6 P52701 S550K 550 S K 0.268 Neutral MSH6 P52701 S550L 550 S L 0.136 Neutral MSH6 P52701 S550M 550 S M 0.51 Pathogenic MSH6 P52701 S550N 550 S N 0.056 Neutral MSH6 P52701 S550P 550 S P 0.12 Neutral MSH6 P52701 S550Q 550 S Q 0.244 Neutral MSH6 P52701 S550R 550 S R 0.294 Neutral MSH6 P52701 S550T 550 S T 0.026 Neutral MSH6 P52701 S550V 550 S V 0.046 Neutral MSH6 P52701 S550W 550 S W 0.642 Pathogenic MSH6 P52701 S550Y 550 S Y 0.602 Pathogenic MSH6 P52701 G551A 551 G A 0.032 Neutral MSH6 P52701 G551C 551 G C 0.372 Neutral MSH6 P52701 G551D 551 G D 0.278 Neutral MSH6 P52701 G551E 551 G E 0.482 Neutral MSH6 P52701 G551F 551 G F 0.78 Pathogenic MSH6 P52701 G551H 551 G H 0.724 Pathogenic MSH6 P52701 G551I 551 G I 0.694 Pathogenic MSH6 P52701 G551K 551 G K 0.438 Neutral MSH6 P52701 G551L 551 G L 0.548 Pathogenic MSH6 P52701 G551M 551 G M 0.714 Pathogenic MSH6 P52701 G551N 551 G N 0.27 Neutral MSH6 P52701 G551P 551 G P 0.65 Pathogenic MSH6 P52701 G551Q 551 G Q 0.396 Neutral MSH6 P52701 G551R 551 G R 0.776 Pathogenic MSH6 P52701 G551S 551 G S 0.032 Neutral MSH6 P52701 G551T 551 G T 0.39 Neutral MSH6 P52701 G551V 551 G V 0.668 Pathogenic MSH6 P52701 G551W 551 G W 0.78 Pathogenic MSH6 P52701 G551Y 551 G Y 0.764 Pathogenic MSH6 P52701 H552A 552 H A 0.042 Neutral MSH6 P52701 H552C 552 H C 0 Neutral MSH6 P52701 H552D 552 H D 0.028 Neutral MSH6 P52701 H552E 552 H E 0.022 Neutral MSH6 P52701 H552F 552 H F 0.07 Neutral MSH6 P52701 H552G 552 H G 0.042 Neutral MSH6 P52701 H552I 552 H I 0.274 Neutral MSH6 P52701 H552K 552 H K 0.026 Neutral MSH6 P52701 H552L 552 H L 0.016 Neutral MSH6 P52701 H552M 552 H M 0.136 Neutral MSH6 P52701 H552N 552 H N 0.002 Neutral MSH6 P52701 H552P 552 H P 0.21 Neutral MSH6 P52701 H552Q 552 H Q 0.006 Neutral MSH6 P52701 H552R 552 H R 0 Neutral MSH6 P52701 H552S 552 H S 0.014 Neutral MSH6 P52701 H552T 552 H T 0.006 Neutral MSH6 P52701 H552V 552 H V 0.016 Neutral MSH6 P52701 H552W 552 H W 0.398 Neutral MSH6 P52701 H552Y 552 H Y 0.028 Neutral MSH6 P52701 T553A 553 T A 0.06 Neutral MSH6 P52701 T553C 553 T C 0.004 Neutral MSH6 P52701 T553D 553 T D 0.046 Neutral MSH6 P52701 T553E 553 T E 0.026 Neutral MSH6 P52701 T553F 553 T F 0.204 Neutral MSH6 P52701 T553G 553 T G 0.002 Neutral MSH6 P52701 T553H 553 T H 0.036 Neutral MSH6 P52701 T553I 553 T I 0.042 Neutral MSH6 P52701 T553K 553 T K 0.026 Neutral MSH6 P52701 T553L 553 T L 0.008 Neutral MSH6 P52701 T553M 553 T M 0.024 Neutral MSH6 P52701 T553N 553 T N 0.012 Neutral MSH6 P52701 T553P 553 T P 0.084 Neutral MSH6 P52701 T553Q 553 T Q 0.002 Neutral MSH6 P52701 T553R 553 T R 0.156 Neutral MSH6 P52701 T553S 553 T S 0 Neutral MSH6 P52701 T553V 553 T V 0.02 Neutral MSH6 P52701 T553W 553 T W 0.39 Neutral MSH6 P52701 T553Y 553 T Y 0.422 Neutral MSH6 P52701 R554A 554 R A 0.2 Neutral MSH6 P52701 R554C 554 R C 0.026 Neutral MSH6 P52701 R554D 554 R D 0.386 Neutral MSH6 P52701 R554E 554 R E 0.316 Neutral MSH6 P52701 R554F 554 R F 0.086 Neutral MSH6 P52701 R554G 554 R G 0.152 Neutral MSH6 P52701 R554H 554 R H 0.014 Neutral MSH6 P52701 R554I 554 R I 0.596 Pathogenic MSH6 P52701 R554K 554 R K 0.068 Neutral MSH6 P52701 R554L 554 R L 0.562 Pathogenic MSH6 P52701 R554M 554 R M 0.372 Neutral MSH6 P52701 R554N 554 R N 0.16 Neutral MSH6 P52701 R554P 554 R P 0.07 Neutral MSH6 P52701 R554Q 554 R Q 0.35 Neutral MSH6 P52701 R554S 554 R S 0.026 Neutral MSH6 P52701 R554T 554 R T 0.402 Neutral MSH6 P52701 R554V 554 R V 0.074 Neutral MSH6 P52701 R554W 554 R W 0.674 Pathogenic MSH6 P52701 R554Y 554 R Y 0.33 Neutral MSH6 P52701 A555C 555 A C 0.254 Neutral MSH6 P52701 A555D 555 A D 0.536 Pathogenic MSH6 P52701 A555E 555 A E 0.456 Neutral MSH6 P52701 A555F 555 A F 0.788 Pathogenic MSH6 P52701 A555G 555 A G 0.214 Neutral MSH6 P52701 A555H 555 A H 0.588 Pathogenic MSH6 P52701 A555I 555 A I 0.518 Pathogenic MSH6 P52701 A555K 555 A K 0.444 Neutral MSH6 P52701 A555L 555 A L 0.478 Neutral MSH6 P52701 A555M 555 A M 0.574 Pathogenic MSH6 P52701 A555N 555 A N 0.464 Neutral MSH6 P52701 A555P 555 A P 0.486 Neutral MSH6 P52701 A555Q 555 A Q 0.416 Neutral MSH6 P52701 A555R 555 A R 0.48 Neutral MSH6 P52701 A555S 555 A S 0.008 Neutral MSH6 P52701 A555T 555 A T 0.026 Neutral MSH6 P52701 A555V 555 A V 0.058 Neutral MSH6 P52701 A555W 555 A W 0.812 Pathogenic MSH6 P52701 A555Y 555 A Y 0.812 Pathogenic MSH6 P52701 Y556A 556 Y A 0.326 Neutral MSH6 P52701 Y556C 556 Y C 0.536 Pathogenic MSH6 P52701 Y556D 556 Y D 0.782 Pathogenic MSH6 P52701 Y556E 556 Y E 0.42 Neutral MSH6 P52701 Y556F 556 Y F 0.076 Neutral 2 MSH6 P52701 Y556G 556 Y G 0.376 Neutral MSH6 P52701 Y556H 556 Y H 0.456 Neutral MSH6 P52701 Y556I 556 Y I 0.158 Neutral MSH6 P52701 Y556K 556 Y K 0.794 Pathogenic MSH6 P52701 Y556L 556 Y L 0.132 Neutral MSH6 P52701 Y556M 556 Y M 0.27 Neutral MSH6 P52701 Y556N 556 Y N 0.608 Pathogenic MSH6 P52701 Y556P 556 Y P 0.696 Pathogenic MSH6 P52701 Y556Q 556 Y Q 0.518 Pathogenic MSH6 P52701 Y556R 556 Y R 0.182 Neutral MSH6 P52701 Y556S 556 Y S 0.372 Neutral MSH6 P52701 Y556T 556 Y T 0.53 Pathogenic MSH6 P52701 Y556V 556 Y V 0.218 Neutral MSH6 P52701 Y556W 556 Y W 0.794 Pathogenic MSH6 P52701 G557A 557 G A 0.768 Pathogenic MSH6 P52701 G557C 557 G C 0.946 Pathogenic MSH6 P52701 G557D 557 G D 0.998 Pathogenic MSH6 P52701 G557E 557 G E 0.986 Pathogenic MSH6 P52701 G557F 557 G F 0.98 Pathogenic MSH6 P52701 G557H 557 G H 0.928 Pathogenic MSH6 P52701 G557I 557 G I 0.97 Pathogenic MSH6 P52701 G557K 557 G K 0.984 Pathogenic MSH6 P52701 G557L 557 G L 0.98 Pathogenic MSH6 P52701 G557M 557 G M 0.992 Pathogenic MSH6 P52701 G557N 557 G N 0.984 Pathogenic MSH6 P52701 G557P 557 G P 0.962 Pathogenic MSH6 P52701 G557Q 557 G Q 0.992 Pathogenic MSH6 P52701 G557R 557 G R 0.998 Pathogenic MSH6 P52701 G557S 557 G S 0.672 Pathogenic MSH6 P52701 G557T 557 G T 0.838 Pathogenic MSH6 P52701 G557V 557 G V 0.982 Pathogenic MSH6 P52701 G557W 557 G W 0.976 Pathogenic MSH6 P52701 G557Y 557 G Y 0.876 Pathogenic MSH6 P52701 V558A 558 V A 0.484 Neutral MSH6 P52701 V558C 558 V C 0.804 Pathogenic MSH6 P52701 V558D 558 V D 0.86 Pathogenic MSH6 P52701 V558E 558 V E 0.964 Pathogenic MSH6 P52701 V558F 558 V F 0.93 Pathogenic MSH6 P52701 V558G 558 V G 0.912 Pathogenic MSH6 P52701 V558H 558 V H 0.898 Pathogenic MSH6 P52701 V558I 558 V I 0.228 Neutral MSH6 P52701 V558K 558 V K 0.986 Pathogenic MSH6 P52701 V558L 558 V L 0.272 Neutral MSH6 P52701 V558M 558 V M 0.908 Pathogenic MSH6 P52701 V558N 558 V N 0.922 Pathogenic MSH6 P52701 V558P 558 V P 0.986 Pathogenic MSH6 P52701 V558Q 558 V Q 0.972 Pathogenic MSH6 P52701 V558R 558 V R 0.948 Pathogenic MSH6 P52701 V558S 558 V S 0.806 Pathogenic MSH6 P52701 V558T 558 V T 0.878 Pathogenic MSH6 P52701 V558W 558 V W 0.954 Pathogenic MSH6 P52701 V558Y 558 V Y 0.974 Pathogenic MSH6 P52701 C559A 559 C A 0.128 Neutral MSH6 P52701 C559D 559 C D 0.93 Pathogenic MSH6 P52701 C559E 559 C E 0.902 Pathogenic MSH6 P52701 C559F 559 C F 0.996 Pathogenic MSH6 P52701 C559G 559 C G 0.378 Neutral MSH6 P52701 C559H 559 C H 0.89 Pathogenic MSH6 P52701 C559I 559 C I 0.842 Pathogenic MSH6 P52701 C559K 559 C K 0.896 Pathogenic MSH6 P52701 C559L 559 C L 0.578 Pathogenic MSH6 P52701 C559M 559 C M 0.69 Pathogenic MSH6 P52701 C559N 559 C N 0.754 Pathogenic MSH6 P52701 C559P 559 C P 0.976 Pathogenic MSH6 P52701 C559Q 559 C Q 0.71 Pathogenic MSH6 P52701 C559R 559 C R 0.996 Pathogenic MSH6 P52701 C559S 559 C S 0.096 Neutral MSH6 P52701 C559T 559 C T 0.13 Neutral MSH6 P52701 C559V 559 C V 0.962 Pathogenic MSH6 P52701 C559W 559 C W 0.996 Pathogenic MSH6 P52701 C559Y 559 C Y 0.992 Pathogenic MSH6 P52701 G56A 56 G A 0.01 Neutral MSH6 P52701 G56C 56 G C 0.14 Neutral MSH6 P52701 G56D 56 G D 0.244 Neutral MSH6 P52701 G56E 56 G E 0.166 Neutral MSH6 P52701 G56F 56 G F 0.498 Neutral MSH6 P52701 G56H 56 G H 0.442 Neutral MSH6 P52701 G56I 56 G I 0.412 Neutral MSH6 P52701 G56K 56 G K 0.272 Neutral MSH6 P52701 G56L 56 G L 0.37 Neutral MSH6 P52701 G56M 56 G M 0.422 Neutral MSH6 P52701 G56N 56 G N 0.252 Neutral MSH6 P52701 G56P 56 G P 0.35 Neutral MSH6 P52701 G56Q 56 G Q 0.262 Neutral MSH6 P52701 G56R 56 G R 0.468 Neutral MSH6 P52701 G56S 56 G S 0.046 Neutral MSH6 P52701 G56T 56 G T 0.272 Neutral MSH6 P52701 G56V 56 G V 0.344 Neutral MSH6 P52701 G56W 56 G W 0.498 Neutral MSH6 P52701 G56Y 56 G Y 0.5 Pathogenic MSH6 P52701 F560A 560 F A 0.24 Neutral MSH6 P52701 F560C 560 F C 0.634 Pathogenic MSH6 P52701 F560D 560 F D 0.75 Pathogenic MSH6 P52701 F560E 560 F E 0.49 Neutral MSH6 P52701 F560G 560 F G 0.464 Neutral MSH6 P52701 F560H 560 F H 0.68 Pathogenic MSH6 P52701 F560I 560 F I 0.146 Neutral MSH6 P52701 F560K 560 F K 0.8 Pathogenic MSH6 P52701 F560L 560 F L 0.112 Neutral MSH6 P52701 F560M 560 F M 0.14 Neutral MSH6 P52701 F560N 560 F N 0.666 Pathogenic MSH6 P52701 F560P 560 F P 0.93 Pathogenic MSH6 P52701 F560Q 560 F Q 0.69 Pathogenic MSH6 P52701 F560R 560 F R 0.88 Pathogenic MSH6 P52701 F560S 560 F S 0.76 Pathogenic MSH6 P52701 F560T 560 F T 0.552 Pathogenic MSH6 P52701 F560V 560 F V 0.166 Neutral MSH6 P52701 F560W 560 F W 0.93 Pathogenic MSH6 P52701 F560Y 560 F Y 0.584 Pathogenic MSH6 P52701 V561A 561 V A 0.1 Neutral MSH6 P52701 V561C 561 V C 0.772 Pathogenic MSH6 P52701 V561D 561 V D 0.848 Pathogenic MSH6 P52701 V561E 561 V E 0.576 Pathogenic MSH6 P52701 V561F 561 V F 0.68 Pathogenic MSH6 P52701 V561G 561 V G 0.894 Pathogenic MSH6 P52701 V561H 561 V H 0.866 Pathogenic MSH6 P52701 V561I 561 V I 0.222 Neutral MSH6 P52701 V561K 561 V K 0.988 Pathogenic MSH6 P52701 V561L 561 V L 0.29 Neutral MSH6 P52701 V561M 561 V M 0.872 Pathogenic MSH6 P52701 V561N 561 V N 0.914 Pathogenic MSH6 P52701 V561P 561 V P 0.982 Pathogenic MSH6 P52701 V561Q 561 V Q 0.972 Pathogenic MSH6 P52701 V561R 561 V R 0.948 Pathogenic MSH6 P52701 V561S 561 V S 0.774 Pathogenic MSH6 P52701 V561T 561 V T 0.2 Neutral MSH6 P52701 V561W 561 V W 0.93 Pathogenic MSH6 P52701 V561Y 561 V Y 0.956 Pathogenic MSH6 P52701 D562A 562 D A 0.79 Pathogenic MSH6 P52701 D562C 562 D C 0.878 Pathogenic MSH6 P52701 D562E 562 D E 0.466 Neutral MSH6 P52701 D562F 562 D F 0.98 Pathogenic MSH6 P52701 D562G 562 D G 0.932 Pathogenic MSH6 P52701 D562H 562 D H 0.626 Pathogenic MSH6 P52701 D562I 562 D I 0.974 Pathogenic MSH6 P52701 D562K 562 D K 0.924 Pathogenic MSH6 P52701 D562L 562 D L 0.574 Pathogenic MSH6 P52701 D562M 562 D M 0.956 Pathogenic MSH6 P52701 D562N 562 D N 0.43 Neutral MSH6 P52701 D562P 562 D P 0.904 Pathogenic MSH6 P52701 D562Q 562 D Q 0.616 Pathogenic MSH6 P52701 D562R 562 D R 0.958 Pathogenic MSH6 P52701 D562S 562 D S 0.562 Pathogenic MSH6 P52701 D562T 562 D T 0.796 Pathogenic MSH6 P52701 D562V 562 D V 0.996 Pathogenic MSH6 P52701 D562W 562 D W 0.98 Pathogenic MSH6 P52701 D562Y 562 D Y 0.974 Pathogenic MSH6 P52701 T563A 563 T A 0.134 Neutral MSH6 P52701 T563C 563 T C 0.198 Neutral MSH6 P52701 T563D 563 T D 0.848 Pathogenic MSH6 P52701 T563E 563 T E 0.42 Neutral MSH6 P52701 T563F 563 T F 0.926 Pathogenic MSH6 P52701 T563G 563 T G 0.588 Pathogenic MSH6 P52701 T563H 563 T H 0.86 Pathogenic MSH6 P52701 T563I 563 T I 0.39 Neutral MSH6 P52701 T563K 563 T K 0.874 Pathogenic MSH6 P52701 T563L 563 T L 0.88 Pathogenic MSH6 P52701 T563M 563 T M 0.966 Pathogenic MSH6 P52701 T563N 563 T N 0.77 Pathogenic MSH6 P52701 T563P 563 T P 0.636 Pathogenic MSH6 P52701 T563Q 563 T Q 0.78 Pathogenic MSH6 P52701 T563R 563 T R 0.968 Pathogenic MSH6 P52701 T563S 563 T S 0.106 Neutral MSH6 P52701 T563V 563 T V 0.27 Neutral MSH6 P52701 T563W 563 T W 0.994 Pathogenic MSH6 P52701 T563Y 563 T Y 0.994 Pathogenic MSH6 P52701 S564A 564 S A 0.12 Neutral MSH6 P52701 S564C 564 S C 0.486 Neutral MSH6 P52701 S564D 564 S D 0.796 Pathogenic MSH6 P52701 S564E 564 S E 0.908 Pathogenic MSH6 P52701 S564F 564 S F 0.978 Pathogenic MSH6 P52701 S564G 564 S G 0.098 Neutral MSH6 P52701 S564H 564 S H 0.922 Pathogenic MSH6 P52701 S564I 564 S I 0.676 Pathogenic MSH6 P52701 S564K 564 S K 0.896 Pathogenic MSH6 P52701 S564L 564 S L 0.874 Pathogenic MSH6 P52701 S564M 564 S M 0.87 Pathogenic MSH6 P52701 S564N 564 S N 0.748 Pathogenic MSH6 P52701 S564P 564 S P 0.612 Pathogenic MSH6 P52701 S564Q 564 S Q 0.588 Pathogenic MSH6 P52701 S564R 564 S R 0.93 Pathogenic MSH6 P52701 S564T 564 S T 0.294 Neutral MSH6 P52701 S564V 564 S V 0.414 Neutral MSH6 P52701 S564W 564 S W 0.97 Pathogenic MSH6 P52701 S564Y 564 S Y 0.968 Pathogenic MSH6 P52701 L565A 565 L A 0.116 Neutral MSH6 P52701 L565C 565 L C 0.108 Neutral MSH6 P52701 L565D 565 L D 0.66 Pathogenic MSH6 P52701 L565E 565 L E 0.62 Pathogenic MSH6 P52701 L565F 565 L F 0.684 Pathogenic MSH6 P52701 L565G 565 L G 0.57 Pathogenic MSH6 P52701 L565H 565 L H 0.166 Neutral MSH6 P52701 L565I 565 L I 0.052 Neutral MSH6 P52701 L565K 565 L K 0.362 Neutral MSH6 P52701 L565M 565 L M 0.028 Neutral MSH6 P52701 L565N 565 L N 0.606 Pathogenic MSH6 P52701 L565P 565 L P 0.726 Pathogenic MSH6 P52701 L565Q 565 L Q 0.382 Neutral MSH6 P52701 L565R 565 L R 0.59 Pathogenic MSH6 P52701 L565S 565 L S 0.142 Neutral MSH6 P52701 L565T 565 L T 0.168 Neutral MSH6 P52701 L565V 565 L V 0.012 Neutral MSH6 P52701 L565W 565 L W 0.81 Pathogenic MSH6 P52701 L565Y 565 L Y 0.796 Pathogenic MSH6 P52701 G566A 566 G A 0.308 Neutral MSH6 P52701 G566C 566 G C 0.942 Pathogenic MSH6 P52701 G566D 566 G D 0.994 Pathogenic MSH6 P52701 G566E 566 G E 0.982 Pathogenic MSH6 P52701 G566F 566 G F 0.986 Pathogenic MSH6 P52701 G566H 566 G H 0.99 Pathogenic MSH6 P52701 G566I 566 G I 0.976 Pathogenic MSH6 P52701 G566K 566 G K 0.768 Pathogenic MSH6 P52701 G566L 566 G L 0.906 Pathogenic MSH6 P52701 G566M 566 G M 0.996 Pathogenic MSH6 P52701 G566N 566 G N 0.68 Pathogenic MSH6 P52701 G566P 566 G P 0.976 Pathogenic MSH6 P52701 G566Q 566 G Q 0.734 Pathogenic MSH6 P52701 G566R 566 G R 1 Pathogenic MSH6 P52701 G566S 566 G S 0.26 Neutral MSH6 P52701 G566T 566 G T 0.886 Pathogenic MSH6 P52701 G566V 566 G V 0.988 Pathogenic MSH6 P52701 G566W 566 G W 0.982 Pathogenic MSH6 P52701 G566Y 566 G Y 0.974 Pathogenic MSH6 P52701 K567A 567 K A 0.066 Neutral MSH6 P52701 K567C 567 K C 0.016 Neutral MSH6 P52701 K567D 567 K D 0.01 Neutral MSH6 P52701 K567E 567 K E 0.012 Neutral MSH6 P52701 K567F 567 K F 0.766 Pathogenic MSH6 P52701 K567G 567 K G 0.144 Neutral MSH6 P52701 K567H 567 K H 0.004 Neutral MSH6 P52701 K567I 567 K I 0.23 Neutral MSH6 P52701 K567L 567 K L 0.104 Neutral MSH6 P52701 K567M 567 K M 0.556 Pathogenic MSH6 P52701 K567N 567 K N 0.162 Neutral MSH6 P52701 K567P 567 K P 0.798 Pathogenic MSH6 P52701 K567Q 567 K Q 0.026 Neutral MSH6 P52701 K567R 567 K R 0.01 Neutral MSH6 P52701 K567S 567 K S 0.252 Neutral MSH6 P52701 K567T 567 K T 0.036 Neutral MSH6 P52701 K567V 567 K V 0.09 Neutral MSH6 P52701 K567W 567 K W 0.948 Pathogenic MSH6 P52701 K567Y 567 K Y 0.29 Neutral MSH6 P52701 F568A 568 F A 0.506 Pathogenic MSH6 P52701 F568C 568 F C 0.312 Neutral MSH6 P52701 F568D 568 F D 0.8 Pathogenic MSH6 P52701 F568E 568 F E 0.272 Neutral MSH6 P52701 F568G 568 F G 0.506 Pathogenic MSH6 P52701 F568H 568 F H 0.75 Pathogenic MSH6 P52701 F568I 568 F I 0.184 Neutral MSH6 P52701 F568K 568 F K 0.83 Pathogenic MSH6 P52701 F568L 568 F L 0.234 Neutral MSH6 P52701 F568M 568 F M 0.772 Pathogenic MSH6 P52701 F568N 568 F N 0.738 Pathogenic MSH6 P52701 F568P 568 F P 0.958 Pathogenic MSH6 P52701 F568Q 568 F Q 0.748 Pathogenic MSH6 P52701 F568R 568 F R 0.894 Pathogenic MSH6 P52701 F568S 568 F S 0.862 Pathogenic MSH6 P52701 F568T 568 F T 0.572 Pathogenic MSH6 P52701 F568V 568 F V 0.148 Neutral MSH6 P52701 F568W 568 F W 0.846 Pathogenic MSH6 P52701 F568Y 568 F Y 0.532 Pathogenic MSH6 P52701 F569A 569 F A 0.234 Neutral MSH6 P52701 F569C 569 F C 0.274 Neutral MSH6 P52701 F569D 569 F D 0.52 Pathogenic MSH6 P52701 F569E 569 F E 0.59 Pathogenic MSH6 P52701 F569G 569 F G 0.338 Neutral MSH6 P52701 F569H 569 F H 0.034 Neutral MSH6 P52701 F569I 569 F I 0.094 Neutral MSH6 P52701 F569K 569 F K 0.1 Neutral MSH6 P52701 F569L 569 F L 0.134 Neutral MSH6 P52701 F569M 569 F M 0.07 Neutral MSH6 P52701 F569N 569 F N 0.098 Neutral MSH6 P52701 F569P 569 F P 0.684 Pathogenic MSH6 P52701 F569Q 569 F Q 0.106 Neutral MSH6 P52701 F569R 569 F R 0.098 Neutral MSH6 P52701 F569S 569 F S 0.08 Neutral MSH6 P52701 F569T 569 F T 0.112 Neutral MSH6 P52701 F569V 569 F V 0.28 Neutral MSH6 P52701 F569W 569 F W 0.84 Pathogenic MSH6 P52701 F569Y 569 F Y 0.066 Neutral MSH6 P52701 P57A 57 P A 0.052 Neutral MSH6 P52701 P57C 57 P C 0.148 Neutral MSH6 P52701 P57D 57 P D 0.078 Neutral MSH6 P52701 P57E 57 P E 0.166 Neutral MSH6 P52701 P57F 57 P F 0.272 Neutral MSH6 P52701 P57G 57 P G 0.092 Neutral MSH6 P52701 P57H 57 P H 0.246 Neutral MSH6 P52701 P57I 57 P I 0.104 Neutral MSH6 P52701 P57K 57 P K 0.05 Neutral MSH6 P52701 P57L 57 P L 0.108 Neutral MSH6 P52701 P57M 57 P M 0.22 Neutral MSH6 P52701 P57N 57 P N 0.068 Neutral MSH6 P52701 P57Q 57 P Q 0.212 Neutral MSH6 P52701 P57R 57 P R 0.214 Neutral MSH6 P52701 P57S 57 P S 0.002 Neutral MSH6 P52701 P57T 57 P T 0.188 Neutral MSH6 P52701 P57V 57 P V 0.184 Neutral MSH6 P52701 P57W 57 P W 0.39 Neutral MSH6 P52701 P57Y 57 P Y 0.32 Neutral MSH6 P52701 I570A 570 I A 0.202 Neutral MSH6 P52701 I570C 570 I C 0.61 Pathogenic MSH6 P52701 I570D 570 I D 0.762 Pathogenic MSH6 P52701 I570E 570 I E 0.766 Pathogenic MSH6 P52701 I570F 570 I F 0.966 Pathogenic MSH6 P52701 I570G 570 I G 0.81 Pathogenic MSH6 P52701 I570H 570 I H 0.842 Pathogenic MSH6 P52701 I570K 570 I K 0.854 Pathogenic MSH6 P52701 I570L 570 I L 0.206 Neutral MSH6 P52701 I570M 570 I M 0.168 Neutral MSH6 P52701 I570N 570 I N 0.788 Pathogenic MSH6 P52701 I570P 570 I P 0.944 Pathogenic MSH6 P52701 I570Q 570 I Q 0.798 Pathogenic MSH6 P52701 I570R 570 I R 0.882 Pathogenic MSH6 P52701 I570S 570 I S 0.628 Pathogenic MSH6 P52701 I570T 570 I T 0.278 Neutral MSH6 P52701 I570V 570 I V 0.122 Neutral MSH6 P52701 I570W 570 I W 0.988 Pathogenic MSH6 P52701 I570Y 570 I Y 0.984 Pathogenic MSH6 P52701 G571A 571 G A 0.32 Neutral MSH6 P52701 G571C 571 G C 0.612 Pathogenic MSH6 P52701 G571D 571 G D 0.972 Pathogenic MSH6 P52701 G571E 571 G E 0.984 Pathogenic MSH6 P52701 G571F 571 G F 0.988 Pathogenic MSH6 P52701 G571H 571 G H 0.992 Pathogenic MSH6 P52701 G571I 571 G I 0.978 Pathogenic MSH6 P52701 G571K 571 G K 0.992 Pathogenic MSH6 P52701 G571L 571 G L 0.988 Pathogenic MSH6 P52701 G571M 571 G M 0.994 Pathogenic MSH6 P52701 G571N 571 G N 0.94 Pathogenic MSH6 P52701 G571P 571 G P 0.982 Pathogenic MSH6 P52701 G571Q 571 G Q 0.98 Pathogenic MSH6 P52701 G571R 571 G R 1 Pathogenic MSH6 P52701 G571S 571 G S 0.296 Neutral MSH6 P52701 G571T 571 G T 0.632 Pathogenic MSH6 P52701 G571V 571 G V 0.92 Pathogenic MSH6 P52701 G571W 571 G W 0.984 Pathogenic MSH6 P52701 G571Y 571 G Y 0.984 Pathogenic MSH6 P52701 Q572A 572 Q A 0.726 Pathogenic MSH6 P52701 Q572C 572 Q C 0.27 Neutral MSH6 P52701 Q572D 572 Q D 0.8 Pathogenic MSH6 P52701 Q572E 572 Q E 0.242 Neutral MSH6 P52701 Q572F 572 Q F 0.932 Pathogenic MSH6 P52701 Q572G 572 Q G 0.206 Neutral MSH6 P52701 Q572H 572 Q H 0.848 Pathogenic MSH6 P52701 Q572I 572 Q I 0.954 Pathogenic MSH6 P52701 Q572K 572 Q K 0.974 Pathogenic MSH6 P52701 Q572L 572 Q L 0.894 Pathogenic MSH6 P52701 Q572M 572 Q M 0.926 Pathogenic MSH6 P52701 Q572N 572 Q N 0.824 Pathogenic MSH6 P52701 Q572P 572 Q P 0.922 Pathogenic MSH6 P52701 Q572R 572 Q R 0.888 Pathogenic MSH6 P52701 Q572S 572 Q S 0.244 Neutral MSH6 P52701 Q572T 572 Q T 0.284 Neutral MSH6 P52701 Q572V 572 Q V 0.924 Pathogenic MSH6 P52701 Q572W 572 Q W 0.964 Pathogenic MSH6 P52701 Q572Y 572 Q Y 0.942 Pathogenic MSH6 P52701 F573A 573 F A 0.5 Pathogenic MSH6 P52701 F573C 573 F C 0.73 Pathogenic MSH6 P52701 F573D 573 F D 0.816 Pathogenic MSH6 P52701 F573E 573 F E 0.87 Pathogenic MSH6 P52701 F573G 573 F G 0.51 Pathogenic MSH6 P52701 F573H 573 F H 0.772 Pathogenic MSH6 P52701 F573I 573 F I 0.372 Neutral MSH6 P52701 F573K 573 F K 0.85 Pathogenic MSH6 P52701 F573L 573 F L 0.354 Neutral MSH6 P52701 F573M 573 F M 0.788 Pathogenic MSH6 P52701 F573N 573 F N 0.766 Pathogenic MSH6 P52701 F573P 573 F P 0.954 Pathogenic MSH6 P52701 F573Q 573 F Q 0.788 Pathogenic MSH6 P52701 F573R 573 F R 0.92 Pathogenic MSH6 P52701 F573S 573 F S 0.882 Pathogenic MSH6 P52701 F573T 573 F T 0.598 Pathogenic MSH6 P52701 F573V 573 F V 0.338 Neutral MSH6 P52701 F573W 573 F W 0.824 Pathogenic MSH6 P52701 F573Y 573 F Y 0.572 Pathogenic MSH6 P52701 S574A 574 S A 0.012 Neutral MSH6 P52701 S574C 574 S C 0.066 Neutral MSH6 P52701 S574D 574 S D 0.006 Neutral MSH6 P52701 S574E 574 S E 0.228 Neutral MSH6 P52701 S574F 574 S F 0.518 Pathogenic MSH6 P52701 S574G 574 S G 0.004 Neutral MSH6 P52701 S574H 574 S H 0.296 Neutral MSH6 P52701 S574I 574 S I 0.218 Neutral MSH6 P52701 S574K 574 S K 0.25 Neutral MSH6 P52701 S574L 574 S L 0.046 Neutral MSH6 P52701 S574M 574 S M 0.384 Neutral MSH6 P52701 S574N 574 S N 0.006 Neutral MSH6 P52701 S574P 574 S P 0.068 Neutral MSH6 P52701 S574Q 574 S Q 0.266 Neutral MSH6 P52701 S574R 574 S R 0.246 Neutral MSH6 P52701 S574T 574 S T 0.016 Neutral MSH6 P52701 S574V 574 S V 0.044 Neutral MSH6 P52701 S574W 574 S W 0.736 Pathogenic MSH6 P52701 S574Y 574 S Y 0.692 Pathogenic MSH6 P52701 D575A 575 D A 0.794 Pathogenic MSH6 P52701 D575C 575 D C 0.89 Pathogenic MSH6 P52701 D575E 575 D E 0.82 Pathogenic MSH6 P52701 D575F 575 D F 0.978 Pathogenic MSH6 P52701 D575G 575 D G 0.956 Pathogenic MSH6 P52701 D575H 575 D H 0.638 Pathogenic MSH6 P52701 D575I 575 D I 0.972 Pathogenic MSH6 P52701 D575K 575 D K 0.928 Pathogenic MSH6 P52701 D575L 575 D L 0.978 Pathogenic MSH6 P52701 D575M 575 D M 0.956 Pathogenic MSH6 P52701 D575N 575 D N 0.868 Pathogenic MSH6 P52701 D575P 575 D P 0.91 Pathogenic MSH6 P52701 D575Q 575 D Q 0.64 Pathogenic MSH6 P52701 D575R 575 D R 0.958 Pathogenic MSH6 P52701 D575S 575 D S 0.594 Pathogenic MSH6 P52701 D575T 575 D T 0.808 Pathogenic MSH6 P52701 D575V 575 D V 0.992 Pathogenic MSH6 P52701 D575W 575 D W 0.982 Pathogenic MSH6 P52701 D575Y 575 D Y 0.976 Pathogenic MSH6 P52701 D576A 576 D A 0.79 Pathogenic MSH6 P52701 D576C 576 D C 0.878 Pathogenic MSH6 P52701 D576E 576 D E 0.804 Pathogenic MSH6 P52701 D576F 576 D F 0.98 Pathogenic MSH6 P52701 D576G 576 D G 0.388 Neutral MSH6 P52701 D576H 576 D H 0.62 Pathogenic MSH6 P52701 D576I 576 D I 0.974 Pathogenic MSH6 P52701 D576K 576 D K 0.918 Pathogenic MSH6 P52701 D576L 576 D L 0.976 Pathogenic MSH6 P52701 D576M 576 D M 0.956 Pathogenic MSH6 P52701 D576N 576 D N 0.852 Pathogenic MSH6 P52701 D576P 576 D P 0.9 Pathogenic MSH6 P52701 D576Q 576 D Q 0.612 Pathogenic MSH6 P52701 D576R 576 D R 0.762 Pathogenic MSH6 P52701 D576S 576 D S 0.356 Neutral MSH6 P52701 D576T 576 D T 0.396 Neutral MSH6 P52701 D576V 576 D V 0.996 Pathogenic MSH6 P52701 D576W 576 D W 0.98 Pathogenic MSH6 P52701 D576Y 576 D Y 0.972 Pathogenic MSH6 P52701 R577A 577 R A 0.09 Neutral MSH6 P52701 R577C 577 R C 0.338 Neutral MSH6 P52701 R577D 577 R D 0.032 Neutral MSH6 P52701 R577E 577 R E 0.046 Neutral MSH6 P52701 R577F 577 R F 0.816 Pathogenic MSH6 P52701 R577G 577 R G 0.26 Neutral MSH6 P52701 R577H 577 R H 0.296 Neutral MSH6 P52701 R577I 577 R I 0.164 Neutral MSH6 P52701 R577K 577 R K 0.036 Neutral MSH6 P52701 R577L 577 R L 0.114 Neutral MSH6 P52701 R577M 577 R M 0.628 Pathogenic MSH6 P52701 R577N 577 R N 0.244 Neutral MSH6 P52701 R577P 577 R P 0.148 Neutral MSH6 P52701 R577Q 577 R Q 0.076 Neutral MSH6 P52701 R577S 577 R S 0.034 Neutral MSH6 P52701 R577T 577 R T 0.506 Pathogenic MSH6 P52701 R577V 577 R V 0.102 Neutral MSH6 P52701 R577W 577 R W 0.858 Pathogenic MSH6 P52701 R577Y 577 R Y 0.85 Pathogenic MSH6 P52701 H578A 578 H A 0.112 Neutral MSH6 P52701 H578C 578 H C 0.024 Neutral MSH6 P52701 H578D 578 H D 0.012 Neutral MSH6 P52701 H578E 578 H E 0.006 Neutral MSH6 P52701 H578F 578 H F 0.228 Neutral MSH6 P52701 H578G 578 H G 0.286 Neutral MSH6 P52701 H578I 578 H I 0.762 Pathogenic MSH6 P52701 H578K 578 H K 0.596 Pathogenic MSH6 P52701 H578L 578 H L 0.364 Neutral MSH6 P52701 H578M 578 H M 0.584 Pathogenic MSH6 P52701 H578N 578 H N 0.014 Neutral MSH6 P52701 H578P 578 H P 0.892 Pathogenic MSH6 P52701 H578Q 578 H Q 0.016 Neutral MSH6 P52701 H578R 578 H R 0.172 Neutral MSH6 P52701 H578S 578 H S 0.046 Neutral MSH6 P52701 H578T 578 H T 0.47 Neutral MSH6 P52701 H578V 578 H V 0.54 Pathogenic MSH6 P52701 H578W 578 H W 0.954 Pathogenic MSH6 P52701 H578Y 578 H Y 0.1 Neutral MSH6 P52701 C579A 579 C A 0.238 Neutral MSH6 P52701 C579D 579 C D 0.584 Pathogenic MSH6 P52701 C579E 579 C E 0.614 Pathogenic MSH6 P52701 C579F 579 C F 0.91 Pathogenic MSH6 P52701 C579G 579 C G 0.038 Neutral MSH6 P52701 C579H 579 C H 0.75 Pathogenic MSH6 P52701 C579I 579 C I 0.838 Pathogenic MSH6 P52701 C579K 579 C K 0.674 Pathogenic MSH6 P52701 C579L 579 C L 0.068 Neutral MSH6 P52701 C579M 579 C M 0.076 Neutral MSH6 P52701 C579N 579 C N 0.018 Neutral MSH6 P52701 C579P 579 C P 0.892 Pathogenic MSH6 P52701 C579Q 579 C Q 0.06 Neutral MSH6 P52701 C579R 579 C R 0.576 Pathogenic MSH6 P52701 C579S 579 C S 0.024 Neutral MSH6 P52701 C579T 579 C T 0.548 Pathogenic MSH6 P52701 C579V 579 C V 0.784 Pathogenic MSH6 P52701 C579W 579 C W 0.954 Pathogenic MSH6 P52701 C579Y 579 C Y 0.57 Pathogenic MSH6 P52701 R58A 58 R A 0.064 Neutral MSH6 P52701 R58C 58 R C 0.148 Neutral MSH6 P52701 R58D 58 R D 0.18 Neutral MSH6 P52701 R58E 58 R E 0.02 Neutral MSH6 P52701 R58F 58 R F 0.28 Neutral MSH6 P52701 R58G 58 R G 0.002 Neutral MSH6 P52701 R58H 58 R H 0.12 Neutral MSH6 P52701 R58I 58 R I 0.304 Neutral MSH6 P52701 R58K 58 R K 0.004 Neutral MSH6 P52701 R58L 58 R L 0.272 Neutral MSH6 P52701 R58M 58 R M 0.164 Neutral MSH6 P52701 R58N 58 R N 0.176 Neutral MSH6 P52701 R58P 58 R P 0.236 Neutral MSH6 P52701 R58Q 58 R Q 0.012 Neutral MSH6 P52701 R58S 58 R S 0.164 Neutral MSH6 P52701 R58T 58 R T 0.142 Neutral MSH6 P52701 R58V 58 R V 0.242 Neutral MSH6 P52701 R58W 58 R W 0.384 Neutral MSH6 P52701 R58Y 58 R Y 0.284 Neutral MSH6 P52701 S580A 580 S A 0.794 Pathogenic MSH6 P52701 S580C 580 S C 0.842 Pathogenic MSH6 P52701 S580D 580 S D 0.332 Neutral MSH6 P52701 S580E 580 S E 0.926 Pathogenic MSH6 P52701 S580F 580 S F 0.978 Pathogenic MSH6 P52701 S580G 580 S G 0.588 Pathogenic MSH6 P52701 S580H 580 S H 0.582 Pathogenic MSH6 P52701 S580I 580 S I 0.87 Pathogenic MSH6 P52701 S580K 580 S K 0.922 Pathogenic MSH6 P52701 S580L 580 S L 0.906 Pathogenic MSH6 P52701 S580M 580 S M 0.746 Pathogenic MSH6 P52701 S580N 580 S N 0.814 Pathogenic MSH6 P52701 S580P 580 S P 0.94 Pathogenic MSH6 P52701 S580Q 580 S Q 0.904 Pathogenic MSH6 P52701 S580R 580 S R 0.728 Pathogenic MSH6 P52701 S580T 580 S T 0.312 Neutral MSH6 P52701 S580V 580 S V 0.942 Pathogenic MSH6 P52701 S580W 580 S W 0.914 Pathogenic MSH6 P52701 S580Y 580 S Y 0.972 Pathogenic MSH6 P52701 R581A 581 R A 0.172 Neutral MSH6 P52701 R581C 581 R C 0.272 Neutral MSH6 P52701 R581D 581 R D 0.646 Pathogenic MSH6 P52701 R581E 581 R E 0.576 Pathogenic MSH6 P52701 R581F 581 R F 0.77 Pathogenic MSH6 P52701 R581G 581 R G 0.094 Neutral MSH6 P52701 R581H 581 R H 0.348 Neutral MSH6 P52701 R581I 581 R I 0.902 Pathogenic MSH6 P52701 R581K 581 R K 0.348 Neutral MSH6 P52701 R581L 581 R L 0.882 Pathogenic MSH6 P52701 R581M 581 R M 0.66 Pathogenic MSH6 P52701 R581N 581 R N 0.134 Neutral MSH6 P52701 R581P 581 R P 0.872 Pathogenic MSH6 P52701 R581Q 581 R Q 0.106 Neutral MSH6 P52701 R581S 581 R S 0.144 Neutral MSH6 P52701 R581T 581 R T 0.174 Neutral MSH6 P52701 R581V 581 R V 0.316 Neutral MSH6 P52701 R581W 581 R W 0.852 Pathogenic MSH6 P52701 R581Y 581 R Y 0.79 Pathogenic MSH6 P52701 F582A 582 F A 0.48 Neutral MSH6 P52701 F582C 582 F C 0.68 Pathogenic MSH6 P52701 F582D 582 F D 0.792 Pathogenic MSH6 P52701 F582E 582 F E 0.852 Pathogenic MSH6 P52701 F582G 582 F G 0.482 Neutral MSH6 P52701 F582H 582 F H 0.73 Pathogenic MSH6 P52701 F582I 582 F I 0.172 Neutral MSH6 P52701 F582K 582 F K 0.836 Pathogenic MSH6 P52701 F582L 582 F L 0.162 Neutral MSH6 P52701 F582M 582 F M 0.16 Neutral MSH6 P52701 F582N 582 F N 0.708 Pathogenic MSH6 P52701 F582P 582 F P 0.952 Pathogenic MSH6 P52701 F582Q 582 F Q 0.724 Pathogenic MSH6 P52701 F582R 582 F R 0.91 Pathogenic MSH6 P52701 F582S 582 F S 0.808 Pathogenic MSH6 P52701 F582T 582 F T 0.604 Pathogenic MSH6 P52701 F582V 582 F V 0.86 Pathogenic MSH6 P52701 F582W 582 F W 0.936 Pathogenic MSH6 P52701 F582Y 582 F Y 0.714 Pathogenic MSH6 P52701 R583A 583 R A 0.438 Neutral MSH6 P52701 R583C 583 R C 0.058 Neutral MSH6 P52701 R583D 583 R D 0.058 Neutral MSH6 P52701 R583E 583 R E 0.062 Neutral MSH6 P52701 R583F 583 R F 0.936 Pathogenic MSH6 P52701 R583G 583 R G 0.14 Neutral MSH6 P52701 R583H 583 R H 0.404 Neutral MSH6 P52701 R583I 583 R I 0.902 Pathogenic MSH6 P52701 R583K 583 R K 0.048 Neutral MSH6 P52701 R583L 583 R L 0.118 Neutral MSH6 P52701 R583M 583 R M 0.668 Pathogenic MSH6 P52701 R583N 583 R N 0.486 Neutral MSH6 P52701 R583P 583 R P 0.846 Pathogenic MSH6 P52701 R583Q 583 R Q 0.172 Neutral MSH6 P52701 R583S 583 R S 0.05 Neutral MSH6 P52701 R583T 583 R T 0.536 Pathogenic MSH6 P52701 R583V 583 R V 0.822 Pathogenic MSH6 P52701 R583W 583 R W 0.914 Pathogenic MSH6 P52701 R583Y 583 R Y 0.822 Pathogenic MSH6 P52701 T584A 584 T A 0.338 Neutral MSH6 P52701 T584C 584 T C 0.23 Neutral MSH6 P52701 T584D 584 T D 0.932 Pathogenic MSH6 P52701 T584E 584 T E 0.934 Pathogenic MSH6 P52701 T584F 584 T F 0.948 Pathogenic MSH6 P52701 T584G 584 T G 0.728 Pathogenic MSH6 P52701 T584H 584 T H 0.916 Pathogenic MSH6 P52701 T584I 584 T I 0.636 Pathogenic MSH6 P52701 T584K 584 T K 0.934 Pathogenic MSH6 P52701 T584L 584 T L 0.94 Pathogenic MSH6 P52701 T584M 584 T M 0.974 Pathogenic MSH6 P52701 T584N 584 T N 0.87 Pathogenic MSH6 P52701 T584P 584 T P 0.642 Pathogenic MSH6 P52701 T584Q 584 T Q 0.874 Pathogenic MSH6 P52701 T584R 584 T R 0.73 Pathogenic MSH6 P52701 T584S 584 T S 0.188 Neutral MSH6 P52701 T584V 584 T V 0.626 Pathogenic MSH6 P52701 T584W 584 T W 0.952 Pathogenic MSH6 P52701 T584Y 584 T Y 0.952 Pathogenic MSH6 P52701 L585A 585 L A 0.184 Neutral MSH6 P52701 L585C 585 L C 0.266 Neutral MSH6 P52701 L585D 585 L D 0.894 Pathogenic MSH6 P52701 L585E 585 L E 0.876 Pathogenic MSH6 P52701 L585F 585 L F 0.448 Neutral MSH6 P52701 L585G 585 L G 0.798 Pathogenic MSH6 P52701 L585H 585 L H 0.796 Pathogenic MSH6 P52701 L585I 585 L I 0.132 Neutral MSH6 P52701 L585K 585 L K 0.744 Pathogenic MSH6 P52701 L585M 585 L M 0.186 Neutral MSH6 P52701 L585N 585 L N 0.762 Pathogenic MSH6 P52701 L585P 585 L P 0.998 Pathogenic MSH6 P52701 L585Q 585 L Q 0.306 Neutral MSH6 P52701 L585R 585 L R 0.988 Pathogenic MSH6 P52701 L585S 585 L S 0.608 Pathogenic MSH6 P52701 L585T 585 L T 0.128 Neutral MSH6 P52701 L585V 585 L V 0.092 Neutral MSH6 P52701 L585W 585 L W 0.94 Pathogenic MSH6 P52701 L585Y 585 L Y 0.902 Pathogenic MSH6 P52701 V586A 586 V A 0.136 Neutral MSH6 P52701 V586C 586 V C 0.346 Neutral MSH6 P52701 V586D 586 V D 0.868 Pathogenic MSH6 P52701 V586E 586 V E 0.982 Pathogenic MSH6 P52701 V586F 586 V F 0.526 Pathogenic MSH6 P52701 V586G 586 V G 0.908 Pathogenic MSH6 P52701 V586H 586 V H 0.814 Pathogenic MSH6 P52701 V586I 586 V I 0.172 Neutral MSH6 P52701 V586K 586 V K 0.974 Pathogenic MSH6 P52701 V586L 586 V L 0.212 Neutral MSH6 P52701 V586M 586 V M 0.416 Neutral MSH6 P52701 V586N 586 V N 0.934 Pathogenic MSH6 P52701 V586P 586 V P 0.974 Pathogenic MSH6 P52701 V586Q 586 V Q 0.992 Pathogenic MSH6 P52701 V586R 586 V R 0.96 Pathogenic MSH6 P52701 V586S 586 V S 0.746 Pathogenic MSH6 P52701 V586T 586 V T 0.3 Neutral MSH6 P52701 V586W 586 V W 0.902 Pathogenic MSH6 P52701 V586Y 586 V Y 0.928 Pathogenic MSH6 P52701 A587C 587 A C 0.706 Pathogenic MSH6 P52701 A587D 587 A D 0.954 Pathogenic MSH6 P52701 A587E 587 A E 0.972 Pathogenic MSH6 P52701 A587F 587 A F 0.994 Pathogenic MSH6 P52701 A587G 587 A G 0.742 Pathogenic MSH6 P52701 A587H 587 A H 0.94 Pathogenic MSH6 P52701 A587I 587 A I 0.966 Pathogenic MSH6 P52701 A587K 587 A K 0.972 Pathogenic MSH6 P52701 A587L 587 A L 0.728 Pathogenic MSH6 P52701 A587M 587 A M 0.676 Pathogenic MSH6 P52701 A587N 587 A N 0.874 Pathogenic MSH6 P52701 A587P 587 A P 0.972 Pathogenic MSH6 P52701 A587Q 587 A Q 0.894 Pathogenic MSH6 P52701 A587R 587 A R 0.976 Pathogenic MSH6 P52701 A587S 587 A S 0.144 Neutral MSH6 P52701 A587T 587 A T 0.198 Neutral MSH6 P52701 A587V 587 A V 0.868 Pathogenic MSH6 P52701 A587W 587 A W 0.996 Pathogenic MSH6 P52701 A587Y 587 A Y 0.932 Pathogenic MSH6 P52701 H588A 588 H A 0.542 Pathogenic MSH6 P52701 H588C 588 H C 0.126 Neutral MSH6 P52701 H588D 588 H D 0.46 Neutral MSH6 P52701 H588E 588 H E 0.062 Neutral MSH6 P52701 H588F 588 H F 0.77 Pathogenic MSH6 P52701 H588G 588 H G 0.29 Neutral MSH6 P52701 H588I 588 H I 0.814 Pathogenic MSH6 P52701 H588K 588 H K 0.348 Neutral MSH6 P52701 H588L 588 H L 0.738 Pathogenic MSH6 P52701 H588M 588 H M 0.648 Pathogenic MSH6 P52701 H588N 588 H N 0.076 Neutral MSH6 P52701 H588P 588 H P 0.926 Pathogenic MSH6 P52701 H588Q 588 H Q 0.06 Neutral MSH6 P52701 H588R 588 H R 0.126 Neutral MSH6 P52701 H588S 588 H S 0.144 Neutral MSH6 P52701 H588T 588 H T 0.598 Pathogenic MSH6 P52701 H588V 588 H V 0.274 Neutral MSH6 P52701 H588W 588 H W 0.94 Pathogenic MSH6 P52701 H588Y 588 H Y 0.788 Pathogenic MSH6 P52701 Y589A 589 Y A 0.236 Neutral MSH6 P52701 Y589C 589 Y C 0.296 Neutral MSH6 P52701 Y589D 589 Y D 0.546 Pathogenic MSH6 P52701 Y589E 589 Y E 0.544 Pathogenic MSH6 P52701 Y589F 589 Y F 0.026 Neutral MSH6 P52701 Y589G 589 Y G 0.242 Neutral MSH6 P52701 Y589H 589 Y H 0.024 Neutral MSH6 P52701 Y589I 589 Y I 0.074 Neutral MSH6 P52701 Y589K 589 Y K 0.53 Pathogenic MSH6 P52701 Y589L 589 Y L 0.052 Neutral MSH6 P52701 Y589M 589 Y M 0.042 Neutral MSH6 P52701 Y589N 589 Y N 0.288 Neutral MSH6 P52701 Y589P 589 Y P 0.38 Neutral MSH6 P52701 Y589Q 589 Y Q 0.322 Neutral MSH6 P52701 Y589R 589 Y R 0.266 Neutral MSH6 P52701 Y589S 589 Y S 0.246 Neutral MSH6 P52701 Y589T 589 Y T 0.142 Neutral MSH6 P52701 Y589V 589 Y V 0.044 Neutral MSH6 P52701 Y589W 589 Y W 0.306 Neutral MSH6 P52701 P59A 59 P A 0.034 Neutral MSH6 P52701 P59C 59 P C 0.148 Neutral MSH6 P52701 P59D 59 P D 0.05 Neutral MSH6 P52701 P59E 59 P E 0.166 Neutral MSH6 P52701 P59F 59 P F 0.272 Neutral MSH6 P52701 P59G 59 P G 0.024 Neutral MSH6 P52701 P59H 59 P H 0.266 Neutral MSH6 P52701 P59I 59 P I 0.104 Neutral MSH6 P52701 P59K 59 P K 0.06 Neutral MSH6 P52701 P59L 59 P L 0.094 Neutral MSH6 P52701 P59M 59 P M 0.22 Neutral MSH6 P52701 P59N 59 P N 0.068 Neutral MSH6 P52701 P59Q 59 P Q 0.15 Neutral MSH6 P52701 P59R 59 P R 0.214 Neutral MSH6 P52701 P59S 59 P S 0.002 Neutral MSH6 P52701 P59T 59 P T 0.034 Neutral MSH6 P52701 P59V 59 P V 0.14 Neutral MSH6 P52701 P59W 59 P W 0.39 Neutral MSH6 P52701 P59Y 59 P Y 0.32 Neutral MSH6 P52701 P590A 590 P A 0.072 Neutral MSH6 P52701 P590C 590 P C 0.138 Neutral MSH6 P52701 P590D 590 P D 0.37 Neutral MSH6 P52701 P590E 590 P E 0.66 Pathogenic MSH6 P52701 P590F 590 P F 0.9 Pathogenic MSH6 P52701 P590G 590 P G 0.06 Neutral MSH6 P52701 P590H 590 P H 0.52 Pathogenic MSH6 P52701 P590I 590 P I 0.132 Neutral MSH6 P52701 P590K 590 P K 0.114 Neutral MSH6 P52701 P590L 590 P L 0.188 Neutral MSH6 P52701 P590M 590 P M 0.198 Neutral MSH6 P52701 P590N 590 P N 0.066 Neutral MSH6 P52701 P590Q 590 P Q 0.13 Neutral MSH6 P52701 P590R 590 P R 0.498 Neutral MSH6 P52701 P590S 590 P S 0.032 Neutral MSH6 P52701 P590T 590 P T 0.04 Neutral MSH6 P52701 P590V 590 P V 0.584 Pathogenic MSH6 P52701 P590W 590 P W 0.882 Pathogenic MSH6 P52701 P590Y 590 P Y 0.864 Pathogenic MSH6 P52701 P591A 591 P A 0.834 Pathogenic MSH6 P52701 P591C 591 P C 0.92 Pathogenic MSH6 P52701 P591D 591 P D 0.87 Pathogenic MSH6 P52701 P591E 591 P E 0.962 Pathogenic MSH6 P52701 P591F 591 P F 1 Pathogenic MSH6 P52701 P591G 591 P G 0.696 Pathogenic MSH6 P52701 P591H 591 P H 0.98 Pathogenic MSH6 P52701 P591I 591 P I 0.528 Pathogenic MSH6 P52701 P591K 591 P K 0.952 Pathogenic MSH6 P52701 P591L 591 P L 0.998 Pathogenic MSH6 P52701 P591M 591 P M 0.962 Pathogenic MSH6 P52701 P591N 591 P N 0.79 Pathogenic MSH6 P52701 P591Q 591 P Q 0.884 Pathogenic MSH6 P52701 P591R 591 P R 0.988 Pathogenic MSH6 P52701 P591S 591 P S 0.342 Neutral MSH6 P52701 P591T 591 P T 0.746 Pathogenic MSH6 P52701 P591V 591 P V 0.354 Neutral MSH6 P52701 P591W 591 P W 0.936 Pathogenic MSH6 P52701 P591Y 591 P Y 0.846 Pathogenic MSH6 P52701 V592A 592 V A 0.032 Neutral MSH6 P52701 V592C 592 V C 0.394 Neutral MSH6 P52701 V592D 592 V D 0.604 Pathogenic MSH6 P52701 V592E 592 V E 0.708 Pathogenic MSH6 P52701 V592F 592 V F 0.624 Pathogenic MSH6 P52701 V592G 592 V G 0.11 Neutral MSH6 P52701 V592H 592 V H 0.54 Pathogenic MSH6 P52701 V592I 592 V I 0.086 Neutral MSH6 P52701 V592K 592 V K 0.206 Neutral MSH6 P52701 V592L 592 V L 0.568 Pathogenic MSH6 P52701 V592M 592 V M 0.266 Neutral MSH6 P52701 V592N 592 V N 0.22 Neutral MSH6 P52701 V592P 592 V P 0.862 Pathogenic MSH6 P52701 V592Q 592 V Q 0.154 Neutral MSH6 P52701 V592R 592 V R 0.566 Pathogenic MSH6 P52701 V592S 592 V S 0.062 Neutral MSH6 P52701 V592T 592 V T 0.086 Neutral MSH6 P52701 V592W 592 V W 0.838 Pathogenic MSH6 P52701 V592Y 592 V Y 0.828 Pathogenic MSH6 P52701 Q593A 593 Q A 0.19 Neutral MSH6 P52701 Q593C 593 Q C 0.166 Neutral MSH6 P52701 Q593D 593 Q D 0.142 Neutral MSH6 P52701 Q593E 593 Q E 0.008 Neutral MSH6 P52701 Q593F 593 Q F 0.566 Pathogenic MSH6 P52701 Q593G 593 Q G 0.18 Neutral MSH6 P52701 Q593H 593 Q H 0.036 Neutral MSH6 P52701 Q593I 593 Q I 0.562 Pathogenic MSH6 P52701 Q593K 593 Q K 0.358 Neutral MSH6 P52701 Q593L 593 Q L 0.132 Neutral MSH6 P52701 Q593M 593 Q M 0.338 Neutral MSH6 P52701 Q593N 593 Q N 0.158 Neutral MSH6 P52701 Q593P 593 Q P 0.486 Neutral MSH6 P52701 Q593R 593 Q R 0.15 Neutral MSH6 P52701 Q593S 593 Q S 0.274 Neutral MSH6 P52701 Q593T 593 Q T 0.202 Neutral MSH6 P52701 Q593V 593 Q V 0.44 Neutral MSH6 P52701 Q593W 593 Q W 0.722 Pathogenic MSH6 P52701 Q593Y 593 Q Y 0.628 Pathogenic MSH6 P52701 V594A 594 V A 0.098 Neutral MSH6 P52701 V594C 594 V C 0.112 Neutral MSH6 P52701 V594D 594 V D 0.2 Neutral MSH6 P52701 V594E 594 V E 0.33 Neutral MSH6 P52701 V594F 594 V F 0.362 Neutral MSH6 P52701 V594G 594 V G 0.292 Neutral MSH6 P52701 V594H 594 V H 0.24 Neutral MSH6 P52701 V594I 594 V I 0.014 Neutral MSH6 P52701 V594K 594 V K 0.296 Neutral MSH6 P52701 V594L 594 V L 0.002 Neutral MSH6 P52701 V594M 594 V M 0.172 Neutral MSH6 P52701 V594N 594 V N 0.222 Neutral MSH6 P52701 V594P 594 V P 0.36 Neutral MSH6 P52701 V594Q 594 V Q 0.332 Neutral MSH6 P52701 V594R 594 V R 0.53 Pathogenic MSH6 P52701 V594S 594 V S 0.154 Neutral MSH6 P52701 V594T 594 V T 0.134 Neutral MSH6 P52701 V594W 594 V W 0.576 Pathogenic MSH6 P52701 V594Y 594 V Y 0.502 Pathogenic MSH6 P52701 L595A 595 L A 0.3 Neutral MSH6 P52701 L595C 595 L C 0.256 Neutral MSH6 P52701 L595D 595 L D 0.586 Pathogenic MSH6 P52701 L595E 595 L E 0.548 Pathogenic MSH6 P52701 L595F 595 L F 0.686 Pathogenic MSH6 P52701 L595G 595 L G 0.568 Pathogenic MSH6 P52701 L595H 595 L H 0.314 Neutral MSH6 P52701 L595I 595 L I 0.022 Neutral MSH6 P52701 L595K 595 L K 0.454 Neutral MSH6 P52701 L595M 595 L M 0.534 Pathogenic MSH6 P52701 L595N 595 L N 0.57 Pathogenic MSH6 P52701 L595P 595 L P 0.77 Pathogenic MSH6 P52701 L595Q 595 L Q 0.3 Neutral MSH6 P52701 L595R 595 L R 0.788 Pathogenic MSH6 P52701 L595S 595 L S 0.456 Neutral MSH6 P52701 L595T 595 L T 0.412 Neutral MSH6 P52701 L595V 595 L V 0.034 Neutral MSH6 P52701 L595W 595 L W 0.79 Pathogenic MSH6 P52701 L595Y 595 L Y 0.776 Pathogenic MSH6 P52701 F596A 596 F A 0.236 Neutral MSH6 P52701 F596C 596 F C 0.246 Neutral MSH6 P52701 F596D 596 F D 0.522 Pathogenic MSH6 P52701 F596E 596 F E 0.592 Pathogenic MSH6 P52701 F596G 596 F G 0.34 Neutral MSH6 P52701 F596H 596 F H 0.182 Neutral MSH6 P52701 F596I 596 F I 0.108 Neutral MSH6 P52701 F596K 596 F K 0.08 Neutral MSH6 P52701 F596L 596 F L 0.038 Neutral MSH6 P52701 F596M 596 F M 0.21 Neutral MSH6 P52701 F596N 596 F N 0.524 Pathogenic MSH6 P52701 F596P 596 F P 0.684 Pathogenic MSH6 P52701 F596Q 596 F Q 0.548 Pathogenic MSH6 P52701 F596R 596 F R 0.55 Pathogenic MSH6 P52701 F596S 596 F S 0.494 Neutral MSH6 P52701 F596T 596 F T 0.054 Neutral MSH6 P52701 F596V 596 F V 0.034 Neutral MSH6 P52701 F596W 596 F W 0.808 Pathogenic MSH6 P52701 F596Y 596 F Y 0.052 Neutral MSH6 P52701 E597A 597 E A 0.448 Neutral MSH6 P52701 E597C 597 E C 0.75 Pathogenic MSH6 P52701 E597D 597 E D 0.402 Neutral MSH6 P52701 E597F 597 E F 0.966 Pathogenic MSH6 P52701 E597G 597 E G 0.382 Neutral MSH6 P52701 E597H 597 E H 0.61 Pathogenic MSH6 P52701 E597I 597 E I 0.98 Pathogenic MSH6 P52701 E597K 597 E K 0.97 Pathogenic MSH6 P52701 E597L 597 E L 0.704 Pathogenic MSH6 P52701 E597M 597 E M 0.914 Pathogenic MSH6 P52701 E597N 597 E N 0.764 Pathogenic MSH6 P52701 E597P 597 E P 0.302 Neutral MSH6 P52701 E597Q 597 E Q 0.34 Neutral MSH6 P52701 E597R 597 E R 0.924 Pathogenic MSH6 P52701 E597S 597 E S 0.89 Pathogenic MSH6 P52701 E597T 597 E T 0.858 Pathogenic MSH6 P52701 E597V 597 E V 0.914 Pathogenic MSH6 P52701 E597W 597 E W 0.984 Pathogenic MSH6 P52701 E597Y 597 E Y 0.964 Pathogenic MSH6 P52701 K598A 598 K A 0.106 Neutral MSH6 P52701 K598C 598 K C 0.426 Neutral MSH6 P52701 K598D 598 K D 0.598 Pathogenic MSH6 P52701 K598E 598 K E 0.694 Pathogenic MSH6 P52701 K598F 598 K F 0.926 Pathogenic MSH6 P52701 K598G 598 K G 0.166 Neutral MSH6 P52701 K598H 598 K H 0.712 Pathogenic MSH6 P52701 K598I 598 K I 0.974 Pathogenic MSH6 P52701 K598L 598 K L 0.448 Neutral MSH6 P52701 K598M 598 K M 0.872 Pathogenic MSH6 P52701 K598N 598 K N 0.252 Neutral MSH6 P52701 K598P 598 K P 0.89 Pathogenic MSH6 P52701 K598Q 598 K Q 0.718 Pathogenic MSH6 P52701 K598R 598 K R 0.098 Neutral MSH6 P52701 K598S 598 K S 0.354 Neutral MSH6 P52701 K598T 598 K T 0.17 Neutral MSH6 P52701 K598V 598 K V 0.51 Pathogenic MSH6 P52701 K598W 598 K W 0.98 Pathogenic MSH6 P52701 K598Y 598 K Y 0.968 Pathogenic MSH6 P52701 G599A 599 G A 0.014 Neutral MSH6 P52701 G599C 599 G C 0.414 Neutral MSH6 P52701 G599D 599 G D 0.302 Neutral MSH6 P52701 G599E 599 G E 0.51 Pathogenic MSH6 P52701 G599F 599 G F 0.524 Pathogenic MSH6 P52701 G599H 599 G H 0.534 Pathogenic MSH6 P52701 G599I 599 G I 0.728 Pathogenic MSH6 P52701 G599K 599 G K 0.46 Neutral MSH6 P52701 G599L 599 G L 0.722 Pathogenic MSH6 P52701 G599M 599 G M 0.736 Pathogenic MSH6 P52701 G599N 599 G N 0.29 Neutral MSH6 P52701 G599P 599 G P 0.684 Pathogenic MSH6 P52701 G599Q 599 G Q 0.502 Pathogenic MSH6 P52701 G599R 599 G R 0.708 Pathogenic MSH6 P52701 G599S 599 G S 0.034 Neutral MSH6 P52701 G599T 599 G T 0.514 Pathogenic MSH6 P52701 G599V 599 G V 0.696 Pathogenic MSH6 P52701 G599W 599 G W 0.806 Pathogenic MSH6 P52701 G599Y 599 G Y 0.782 Pathogenic MSH6 P52701 T6A 6 T A 0.078 Neutral MSH6 P52701 T6C 6 T C 0.064 Neutral MSH6 P52701 T6D 6 T D 0.058 Neutral MSH6 P52701 T6E 6 T E 0.062 Neutral MSH6 P52701 T6F 6 T F 0.214 Neutral MSH6 P52701 T6G 6 T G 0.058 Neutral MSH6 P52701 T6H 6 T H 0.084 Neutral MSH6 P52701 T6I 6 T I 0.066 Neutral MSH6 P52701 T6K 6 T K 0.042 Neutral MSH6 P52701 T6L 6 T L 0.07 Neutral MSH6 P52701 T6M 6 T M 0.098 Neutral MSH6 P52701 T6N 6 T N 0.02 Neutral MSH6 P52701 T6P 6 T P 0.1 Neutral MSH6 P52701 T6Q 6 T Q 0.052 Neutral MSH6 P52701 T6R 6 T R 0.26 Neutral MSH6 P52701 T6S 6 T S 0 Neutral MSH6 P52701 T6V 6 T V 0.206 Neutral MSH6 P52701 T6W 6 T W 0.466 Neutral MSH6 P52701 T6Y 6 T Y 0.424 Neutral MSH6 P52701 L60A 60 L A 0.008 Neutral MSH6 P52701 L60C 60 L C 0.094 Neutral MSH6 P52701 L60D 60 L D 0.158 Neutral MSH6 P52701 L60E 60 L E 0.144 Neutral MSH6 P52701 L60F 60 L F 0.204 Neutral MSH6 P52701 L60G 60 L G 0.184 Neutral MSH6 P52701 L60H 60 L H 0.084 Neutral MSH6 P52701 L60I 60 L I 0.072 Neutral MSH6 P52701 L60K 60 L K 0.084 Neutral MSH6 P52701 L60M 60 L M 0.132 Neutral MSH6 P52701 L60N 60 L N 0.148 Neutral MSH6 P52701 L60P 60 L P 0.24 Neutral MSH6 P52701 L60Q 60 L Q 0.064 Neutral MSH6 P52701 L60R 60 L R 0.232 Neutral MSH6 P52701 L60S 60 L S 0.086 Neutral MSH6 P52701 L60T 60 L T 0.03 Neutral MSH6 P52701 L60V 60 L V 0.08 Neutral MSH6 P52701 L60W 60 L W 0.334 Neutral MSH6 P52701 L60Y 60 L Y 0.284 Neutral MSH6 P52701 N600A 600 N A 0.012 Neutral MSH6 P52701 N600C 600 N C 0.232 Neutral MSH6 P52701 N600D 600 N D 0.132 Neutral MSH6 P52701 N600E 600 N E 0.148 Neutral MSH6 P52701 N600F 600 N F 0.58 Pathogenic MSH6 P52701 N600G 600 N G 0.024 Neutral MSH6 P52701 N600H 600 N H 0.362 Neutral MSH6 P52701 N600I 600 N I 0.432 Neutral MSH6 P52701 N600K 600 N K 0.04 Neutral MSH6 P52701 N600L 600 N L 0.484 Neutral MSH6 P52701 N600M 600 N M 0.362 Neutral MSH6 P52701 N600P 600 N P 0.49 Neutral MSH6 P52701 N600Q 600 N Q 0.114 Neutral MSH6 P52701 N600R 600 N R 0.258 Neutral MSH6 P52701 N600S 600 N S 0.008 Neutral MSH6 P52701 N600T 600 N T 0.222 Neutral MSH6 P52701 N600V 600 N V 0.426 Neutral MSH6 P52701 N600W 600 N W 0.712 Pathogenic MSH6 P52701 N600Y 600 N Y 0.666 Pathogenic MSH6 P52701 L601A 601 L A 0.088 Neutral MSH6 P52701 L601C 601 L C 0.134 Neutral MSH6 P52701 L601D 601 L D 0.244 Neutral MSH6 P52701 L601E 601 L E 0.22 Neutral MSH6 P52701 L601F 601 L F 0.362 Neutral MSH6 P52701 L601G 601 L G 0.264 Neutral MSH6 P52701 L601H 601 L H 0.126 Neutral MSH6 P52701 L601I 601 L I 0.016 Neutral MSH6 P52701 L601K 601 L K 0.166 Neutral MSH6 P52701 L601M 601 L M 0.182 Neutral MSH6 P52701 L601N 601 L N 0.11 Neutral MSH6 P52701 L601P 601 L P 0.11 Neutral MSH6 P52701 L601Q 601 L Q 0.104 Neutral MSH6 P52701 L601R 601 L R 0.492 Neutral MSH6 P52701 L601S 601 L S 0.28 Neutral MSH6 P52701 L601T 601 L T 0.118 Neutral MSH6 P52701 L601V 601 L V 0 Neutral MSH6 P52701 L601W 601 L W 0.524 Pathogenic MSH6 P52701 L601Y 601 L Y 0.484 Neutral MSH6 P52701 S602A 602 S A 0.366 Neutral MSH6 P52701 S602C 602 S C 0.36 Neutral MSH6 P52701 S602D 602 S D 0.382 Neutral MSH6 P52701 S602E 602 S E 0.616 Pathogenic MSH6 P52701 S602F 602 S F 0.776 Pathogenic MSH6 P52701 S602G 602 S G 0.276 Neutral MSH6 P52701 S602H 602 S H 0.7 Pathogenic MSH6 P52701 S602I 602 S I 0.48 Neutral MSH6 P52701 S602K 602 S K 0.632 Pathogenic MSH6 P52701 S602L 602 S L 0.178 Neutral MSH6 P52701 S602M 602 S M 0.916 Pathogenic MSH6 P52701 S602N 602 S N 0.342 Neutral MSH6 P52701 S602P 602 S P 0.494 Neutral MSH6 P52701 S602Q 602 S Q 0.58 Pathogenic MSH6 P52701 S602R 602 S R 0.71 Pathogenic MSH6 P52701 S602T 602 S T 0.058 Neutral MSH6 P52701 S602V 602 S V 0.74 Pathogenic MSH6 P52701 S602W 602 S W 0.918 Pathogenic MSH6 P52701 S602Y 602 S Y 0.89 Pathogenic MSH6 P52701 K603A 603 K A 0.028 Neutral MSH6 P52701 K603C 603 K C 0.028 Neutral MSH6 P52701 K603D 603 K D 0.05 Neutral MSH6 P52701 K603E 603 K E 0.004 Neutral MSH6 P52701 K603F 603 K F 0.212 Neutral MSH6 P52701 K603G 603 K G 0.042 Neutral MSH6 P52701 K603H 603 K H 0.048 Neutral MSH6 P52701 K603I 603 K I 0.19 Neutral MSH6 P52701 K603L 603 K L 0.052 Neutral MSH6 P52701 K603M 603 K M 0.146 Neutral MSH6 P52701 K603N 603 K N 0.046 Neutral MSH6 P52701 K603P 603 K P 0.01 Neutral MSH6 P52701 K603Q 603 K Q 0.006 Neutral MSH6 P52701 K603R 603 K R 0.016 Neutral MSH6 P52701 K603S 603 K S 0.012 Neutral MSH6 P52701 K603T 603 K T 0.014 Neutral MSH6 P52701 K603V 603 K V 0.022 Neutral MSH6 P52701 K603W 603 K W 0.396 Neutral MSH6 P52701 K603Y 603 K Y 0.324 Neutral MSH6 P52701 E604A 604 E A 0.178 Neutral MSH6 P52701 E604C 604 E C 0.118 Neutral MSH6 P52701 E604D 604 E D 0.004 Neutral MSH6 P52701 E604F 604 E F 0.422 Neutral MSH6 P52701 E604G 604 E G 0.006 Neutral MSH6 P52701 E604H 604 E H 0.24 Neutral MSH6 P52701 E604I 604 E I 0.482 Neutral MSH6 P52701 E604K 604 E K 0.006 Neutral MSH6 P52701 E604L 604 E L 0.442 Neutral MSH6 P52701 E604M 604 E M 0.282 Neutral MSH6 P52701 E604N 604 E N 0.086 Neutral MSH6 P52701 E604P 604 E P 0.184 Neutral MSH6 P52701 E604Q 604 E Q 0.024 Neutral MSH6 P52701 E604R 604 E R 0.024 Neutral MSH6 P52701 E604S 604 E S 0.22 Neutral MSH6 P52701 E604T 604 E T 0.016 Neutral MSH6 P52701 E604V 604 E V 0.392 Neutral MSH6 P52701 E604W 604 E W 0.696 Pathogenic MSH6 P52701 E604Y 604 E Y 0.58 Pathogenic MSH6 P52701 T605A 605 T A 0.278 Neutral MSH6 P52701 T605C 605 T C 0.294 Neutral MSH6 P52701 T605D 605 T D 0.358 Neutral MSH6 P52701 T605E 605 T E 0.44 Neutral MSH6 P52701 T605F 605 T F 0.582 Pathogenic MSH6 P52701 T605G 605 T G 0.264 Neutral MSH6 P52701 T605H 605 T H 0.442 Neutral MSH6 P52701 T605I 605 T I 0.26 Neutral MSH6 P52701 T605K 605 T K 0.346 Neutral MSH6 P52701 T605L 605 T L 0.05 Neutral MSH6 P52701 T605M 605 T M 0.296 Neutral MSH6 P52701 T605N 605 T N 0.266 Neutral MSH6 P52701 T605P 605 T P 0.492 Neutral MSH6 P52701 T605Q 605 T Q 0.212 Neutral MSH6 P52701 T605R 605 T R 0.682 Pathogenic MSH6 P52701 T605S 605 T S 0.264 Neutral MSH6 P52701 T605V 605 T V 0.646 Pathogenic MSH6 P52701 T605W 605 T W 0.878 Pathogenic MSH6 P52701 T605Y 605 T Y 0.862 Pathogenic MSH6 P52701 K606A 606 K A 0.062 Neutral MSH6 P52701 K606C 606 K C 0.038 Neutral MSH6 P52701 K606D 606 K D 0.074 Neutral MSH6 P52701 K606E 606 K E 0.058 Neutral MSH6 P52701 K606F 606 K F 0.262 Neutral MSH6 P52701 K606G 606 K G 0.142 Neutral MSH6 P52701 K606H 606 K H 0 Neutral MSH6 P52701 K606I 606 K I 0.25 Neutral MSH6 P52701 K606L 606 K L 0.042 Neutral MSH6 P52701 K606M 606 K M 0.166 Neutral MSH6 P52701 K606N 606 K N 0.048 Neutral MSH6 P52701 K606P 606 K P 0.282 Neutral MSH6 P52701 K606Q 606 K Q 0.006 Neutral MSH6 P52701 K606R 606 K R 0.002 Neutral MSH6 P52701 K606S 606 K S 0.024 Neutral MSH6 P52701 K606T 606 K T 0.096 Neutral MSH6 P52701 K606V 606 K V 0.214 Neutral MSH6 P52701 K606W 606 K W 0.516 Pathogenic MSH6 P52701 K606Y 606 K Y 0.436 Neutral MSH6 P52701 T607A 607 T A 0.068 Neutral MSH6 P52701 T607C 607 T C 0.442 Neutral MSH6 P52701 T607D 607 T D 0.458 Neutral MSH6 P52701 T607E 607 T E 0.138 Neutral MSH6 P52701 T607F 607 T F 0.688 Pathogenic MSH6 P52701 T607G 607 T G 0.03 Neutral MSH6 P52701 T607H 607 T H 0.372 Neutral MSH6 P52701 T607I 607 T I 0.108 Neutral MSH6 P52701 T607K 607 T K 0.084 Neutral MSH6 P52701 T607L 607 T L 0.074 Neutral MSH6 P52701 T607M 607 T M 0.144 Neutral MSH6 P52701 T607N 607 T N 0.008 Neutral MSH6 P52701 T607P 607 T P 0.59 Pathogenic MSH6 P52701 T607Q 607 T Q 0.018 Neutral MSH6 P52701 T607R 607 T R 0.648 Pathogenic MSH6 P52701 T607S 607 T S 0.012 Neutral MSH6 P52701 T607V 607 T V 0.194 Neutral MSH6 P52701 T607W 607 T W 0.914 Pathogenic MSH6 P52701 T607Y 607 T Y 0.908 Pathogenic MSH6 P52701 I608A 608 I A 0.014 Neutral MSH6 P52701 I608C 608 I C 0.02 Neutral MSH6 P52701 I608D 608 I D 0.24 Neutral MSH6 P52701 I608E 608 I E 0.042 Neutral MSH6 P52701 I608F 608 I F 0.116 Neutral MSH6 P52701 I608G 608 I G 0.122 Neutral MSH6 P52701 I608H 608 I H 0.018 Neutral MSH6 P52701 I608K 608 I K 0.058 Neutral MSH6 P52701 I608L 608 I L 0.004 Neutral MSH6 P52701 I608M 608 I M 0.03 Neutral MSH6 P52701 I608N 608 I N 0.112 Neutral MSH6 P52701 I608P 608 I P 0.27 Neutral MSH6 P52701 I608Q 608 I Q 0.2 Neutral MSH6 P52701 I608R 608 I R 0.418 Neutral MSH6 P52701 I608S 608 I S 0.082 Neutral MSH6 P52701 I608T 608 I T 0.012 Neutral MSH6 P52701 I608V 608 I V 0.004 Neutral MSH6 P52701 I608W 608 I W 0.606 Pathogenic MSH6 P52701 I608Y 608 I Y 0.578 Pathogenic MSH6 P52701 L609A 609 L A 0.144 Neutral MSH6 P52701 L609C 609 L C 0.122 Neutral MSH6 P52701 L609D 609 L D 0.248 Neutral MSH6 P52701 L609E 609 L E 0.6 Pathogenic MSH6 P52701 L609F 609 L F 0.28 Neutral MSH6 P52701 L609G 609 L G 0.57 Pathogenic MSH6 P52701 L609H 609 L H 0.388 Neutral MSH6 P52701 L609I 609 L I 0.036 Neutral MSH6 P52701 L609K 609 L K 0.044 Neutral MSH6 P52701 L609M 609 L M 0.02 Neutral MSH6 P52701 L609N 609 L N 0.084 Neutral MSH6 P52701 L609P 609 L P 0.952 Pathogenic MSH6 P52701 L609Q 609 L Q 0.336 Neutral MSH6 P52701 L609R 609 L R 0.556 Pathogenic MSH6 P52701 L609S 609 L S 0.048 Neutral MSH6 P52701 L609T 609 L T 0.416 Neutral MSH6 P52701 L609V 609 L V 0.002 Neutral MSH6 P52701 L609W 609 L W 0.868 Pathogenic MSH6 P52701 L609Y 609 L Y 0.872 Pathogenic MSH6 P52701 A61C 61 A C 0.182 Neutral MSH6 P52701 A61D 61 A D 0.266 Neutral MSH6 P52701 A61E 61 A E 0.302 Neutral MSH6 P52701 A61F 61 A F 0.468 Neutral MSH6 P52701 A61G 61 A G 0.004 Neutral MSH6 P52701 A61H 61 A H 0.304 Neutral MSH6 P52701 A61I 61 A I 0.406 Neutral MSH6 P52701 A61K 61 A K 0.262 Neutral MSH6 P52701 A61L 61 A L 0.414 Neutral MSH6 P52701 A61M 61 A M 0.29 Neutral MSH6 P52701 A61N 61 A N 0.296 Neutral MSH6 P52701 A61P 61 A P 0.138 Neutral MSH6 P52701 A61Q 61 A Q 0.302 Neutral MSH6 P52701 A61R 61 A R 0.36 Neutral MSH6 P52701 A61S 61 A S 0.008 Neutral MSH6 P52701 A61T 61 A T 0.166 Neutral MSH6 P52701 A61V 61 A V 0.202 Neutral MSH6 P52701 A61W 61 A W 0.504 Pathogenic MSH6 P52701 A61Y 61 A Y 0.5 Pathogenic MSH6 P52701 K610A 610 K A 0.106 Neutral MSH6 P52701 K610C 610 K C 0.074 Neutral MSH6 P52701 K610D 610 K D 0.014 Neutral MSH6 P52701 K610E 610 K E 0.078 Neutral MSH6 P52701 K610F 610 K F 0.794 Pathogenic MSH6 P52701 K610G 610 K G 0.142 Neutral MSH6 P52701 K610H 610 K H 0.066 Neutral MSH6 P52701 K610I 610 K I 0.858 Pathogenic MSH6 P52701 K610L 610 K L 0.632 Pathogenic MSH6 P52701 K610M 610 K M 0.596 Pathogenic MSH6 P52701 K610N 610 K N 0.024 Neutral MSH6 P52701 K610P 610 K P 0.766 Pathogenic MSH6 P52701 K610Q 610 K Q 0.168 Neutral MSH6 P52701 K610R 610 K R 0.088 Neutral MSH6 P52701 K610S 610 K S 0.198 Neutral MSH6 P52701 K610T 610 K T 0.03 Neutral MSH6 P52701 K610V 610 K V 0.704 Pathogenic MSH6 P52701 K610W 610 K W 0.94 Pathogenic MSH6 P52701 K610Y 610 K Y 0.888 Pathogenic MSH6 P52701 S611A 611 S A 0.016 Neutral MSH6 P52701 S611C 611 S C 0.148 Neutral MSH6 P52701 S611D 611 S D 0.008 Neutral MSH6 P52701 S611E 611 S E 0.358 Neutral MSH6 P52701 S611F 611 S F 0.64 Pathogenic MSH6 P52701 S611G 611 S G 0.006 Neutral MSH6 P52701 S611H 611 S H 0.328 Neutral MSH6 P52701 S611I 611 S I 0.272 Neutral MSH6 P52701 S611K 611 S K 0.302 Neutral MSH6 P52701 S611L 611 S L 0.062 Neutral MSH6 P52701 S611M 611 S M 0.444 Neutral MSH6 P52701 S611N 611 S N 0.008 Neutral MSH6 P52701 S611P 611 S P 0.074 Neutral MSH6 P52701 S611Q 611 S Q 0.336 Neutral MSH6 P52701 S611R 611 S R 0.554 Pathogenic MSH6 P52701 S611T 611 S T 0.022 Neutral MSH6 P52701 S611V 611 S V 0.052 Neutral MSH6 P52701 S611W 611 S W 0.856 Pathogenic MSH6 P52701 S611Y 611 S Y 0.806 Pathogenic MSH6 P52701 S612A 612 S A 0.034 Neutral MSH6 P52701 S612C 612 S C 0.036 Neutral MSH6 P52701 S612D 612 S D 0.054 Neutral MSH6 P52701 S612E 612 S E 0.378 Neutral MSH6 P52701 S612F 612 S F 0.738 Pathogenic MSH6 P52701 S612G 612 S G 0.318 Neutral MSH6 P52701 S612H 612 S H 0.52 Pathogenic MSH6 P52701 S612I 612 S I 0.332 Neutral MSH6 P52701 S612K 612 S K 0.386 Neutral MSH6 P52701 S612L 612 S L 0.118 Neutral MSH6 P52701 S612M 612 S M 0.91 Pathogenic MSH6 P52701 S612N 612 S N 0.038 Neutral MSH6 P52701 S612P 612 S P 0.452 Neutral MSH6 P52701 S612Q 612 S Q 0.402 Neutral MSH6 P52701 S612R 612 S R 0.406 Neutral MSH6 P52701 S612T 612 S T 0.04 Neutral MSH6 P52701 S612V 612 S V 0.204 Neutral MSH6 P52701 S612W 612 S W 0.91 Pathogenic MSH6 P52701 S612Y 612 S Y 0.89 Pathogenic MSH6 P52701 L613A 613 L A 0.042 Neutral MSH6 P52701 L613C 613 L C 0.03 Neutral MSH6 P52701 L613D 613 L D 0.606 Pathogenic MSH6 P52701 L613E 613 L E 0.11 Neutral MSH6 P52701 L613F 613 L F 0.786 Pathogenic MSH6 P52701 L613G 613 L G 0.12 Neutral MSH6 P52701 L613H 613 L H 0.164 Neutral MSH6 P52701 L613I 613 L I 0.12 Neutral MSH6 P52701 L613K 613 L K 0.042 Neutral MSH6 P52701 L613M 613 L M 0.07 Neutral MSH6 P52701 L613N 613 L N 0.518 Pathogenic MSH6 P52701 L613P 613 L P 0.212 Neutral MSH6 P52701 L613Q 613 L Q 0.302 Neutral MSH6 P52701 L613R 613 L R 0.774 Pathogenic MSH6 P52701 L613S 613 L S 0.048 Neutral MSH6 P52701 L613T 613 L T 0.032 Neutral MSH6 P52701 L613V 613 L V 0.012 Neutral MSH6 P52701 L613W 613 L W 0.868 Pathogenic MSH6 P52701 L613Y 613 L Y 0.88 Pathogenic MSH6 P52701 S614A 614 S A 0.014 Neutral MSH6 P52701 S614C 614 S C 0.116 Neutral MSH6 P52701 S614D 614 S D 0.184 Neutral MSH6 P52701 S614E 614 S E 0.298 Neutral MSH6 P52701 S614F 614 S F 0.64 Pathogenic MSH6 P52701 S614G 614 S G 0.184 Neutral MSH6 P52701 S614H 614 S H 0.348 Neutral MSH6 P52701 S614I 614 S I 0.23 Neutral MSH6 P52701 S614K 614 S K 0.316 Neutral MSH6 P52701 S614L 614 S L 0.084 Neutral MSH6 P52701 S614M 614 S M 0.456 Neutral MSH6 P52701 S614N 614 S N 0.114 Neutral MSH6 P52701 S614P 614 S P 0.084 Neutral MSH6 P52701 S614Q 614 S Q 0.336 Neutral MSH6 P52701 S614R 614 S R 0.328 Neutral MSH6 P52701 S614T 614 S T 0.03 Neutral MSH6 P52701 S614V 614 S V 0.058 Neutral MSH6 P52701 S614W 614 S W 0.856 Pathogenic MSH6 P52701 S614Y 614 S Y 0.82 Pathogenic MSH6 P52701 C615A 615 C A 0.074 Neutral MSH6 P52701 C615D 615 C D 0.158 Neutral MSH6 P52701 C615E 615 C E 0.582 Pathogenic MSH6 P52701 C615F 615 C F 0.602 Pathogenic MSH6 P52701 C615G 615 C G 0.058 Neutral MSH6 P52701 C615H 615 C H 0.526 Pathogenic MSH6 P52701 C615I 615 C I 0.3 Neutral MSH6 P52701 C615K 615 C K 0.102 Neutral MSH6 P52701 C615L 615 C L 0.84 Pathogenic MSH6 P52701 C615M 615 C M 0.632 Pathogenic MSH6 P52701 C615N 615 C N 0.038 Neutral MSH6 P52701 C615P 615 C P 0.862 Pathogenic MSH6 P52701 C615Q 615 C Q 0.044 Neutral MSH6 P52701 C615R 615 C R 0.562 Pathogenic MSH6 P52701 C615S 615 C S 0.042 Neutral MSH6 P52701 C615T 615 C T 0.028 Neutral MSH6 P52701 C615V 615 C V 0.1 Neutral MSH6 P52701 C615W 615 C W 0.952 Pathogenic MSH6 P52701 C615Y 615 C Y 0.96 Pathogenic MSH6 P52701 S616A 616 S A 0.042 Neutral MSH6 P52701 S616C 616 S C 0.052 Neutral MSH6 P52701 S616D 616 S D 0.496 Neutral MSH6 P52701 S616E 616 S E 0.736 Pathogenic MSH6 P52701 S616F 616 S F 0.794 Pathogenic MSH6 P52701 S616G 616 S G 0.214 Neutral MSH6 P52701 S616H 616 S H 0.8 Pathogenic MSH6 P52701 S616I 616 S I 0.36 Neutral MSH6 P52701 S616K 616 S K 0.736 Pathogenic MSH6 P52701 S616L 616 S L 0.148 Neutral MSH6 P52701 S616M 616 S M 0.59 Pathogenic MSH6 P52701 S616N 616 S N 0.436 Neutral MSH6 P52701 S616P 616 S P 0.234 Neutral MSH6 P52701 S616Q 616 S Q 0.69 Pathogenic MSH6 P52701 S616R 616 S R 0.81 Pathogenic MSH6 P52701 S616T 616 S T 0.062 Neutral MSH6 P52701 S616V 616 S V 0.08 Neutral MSH6 P52701 S616W 616 S W 0.952 Pathogenic MSH6 P52701 S616Y 616 S Y 0.932 Pathogenic MSH6 P52701 L617A 617 L A 0.544 Pathogenic MSH6 P52701 L617C 617 L C 0.656 Pathogenic MSH6 P52701 L617D 617 L D 0.906 Pathogenic MSH6 P52701 L617E 617 L E 0.882 Pathogenic MSH6 P52701 L617F 617 L F 0.602 Pathogenic MSH6 P52701 L617G 617 L G 0.798 Pathogenic MSH6 P52701 L617H 617 L H 0.742 Pathogenic MSH6 P52701 L617I 617 L I 0.122 Neutral MSH6 P52701 L617K 617 L K 0.124 Neutral MSH6 P52701 L617M 617 L M 0.154 Neutral MSH6 P52701 L617N 617 L N 0.484 Neutral MSH6 P52701 L617P 617 L P 0.504 Pathogenic MSH6 P52701 L617Q 617 L Q 0.16 Neutral MSH6 P52701 L617R 617 L R 0.546 Pathogenic MSH6 P52701 L617S 617 L S 0.558 Pathogenic MSH6 P52701 L617T 617 L T 0.322 Neutral MSH6 P52701 L617V 617 L V 0.08 Neutral MSH6 P52701 L617W 617 L W 0.84 Pathogenic MSH6 P52701 L617Y 617 L Y 0.674 Pathogenic MSH6 P52701 Q618A 618 Q A 0.358 Neutral MSH6 P52701 Q618C 618 Q C 0.302 Neutral MSH6 P52701 Q618D 618 Q D 0.55 Pathogenic MSH6 P52701 Q618E 618 Q E 0.554 Pathogenic MSH6 P52701 Q618F 618 Q F 0.844 Pathogenic MSH6 P52701 Q618G 618 Q G 0.46 Neutral MSH6 P52701 Q618H 618 Q H 0.096 Neutral MSH6 P52701 Q618I 618 Q I 0.554 Pathogenic MSH6 P52701 Q618K 618 Q K 0.21 Neutral MSH6 P52701 Q618L 618 Q L 0.194 Neutral MSH6 P52701 Q618M 618 Q M 0.182 Neutral MSH6 P52701 Q618N 618 Q N 0.076 Neutral MSH6 P52701 Q618P 618 Q P 0.852 Pathogenic MSH6 P52701 Q618R 618 Q R 0.074 Neutral MSH6 P52701 Q618S 618 Q S 0.102 Neutral MSH6 P52701 Q618T 618 Q T 0.51 Pathogenic MSH6 P52701 Q618V 618 Q V 0.116 Neutral MSH6 P52701 Q618W 618 Q W 0.922 Pathogenic MSH6 P52701 Q618Y 618 Q Y 0.902 Pathogenic MSH6 P52701 E619A 619 E A 0.228 Neutral MSH6 P52701 E619C 619 E C 0.338 Neutral MSH6 P52701 E619D 619 E D 0.04 Neutral MSH6 P52701 E619F 619 E F 0.882 Pathogenic MSH6 P52701 E619G 619 E G 0.038 Neutral MSH6 P52701 E619H 619 E H 0.618 Pathogenic MSH6 P52701 E619I 619 E I 0.938 Pathogenic MSH6 P52701 E619K 619 E K 0.05 Neutral MSH6 P52701 E619L 619 E L 0.918 Pathogenic MSH6 P52701 E619M 619 E M 0.658 Pathogenic MSH6 P52701 E619N 619 E N 0.012 Neutral MSH6 P52701 E619P 619 E P 0.892 Pathogenic MSH6 P52701 E619Q 619 E Q 0.366 Neutral MSH6 P52701 E619R 619 E R 0.118 Neutral MSH6 P52701 E619S 619 E S 0.054 Neutral MSH6 P52701 E619T 619 E T 0.058 Neutral MSH6 P52701 E619V 619 E V 0.728 Pathogenic MSH6 P52701 E619W 619 E W 0.972 Pathogenic MSH6 P52701 E619Y 619 E Y 0.382 Neutral MSH6 P52701 R62A 62 R A 0.08 Neutral MSH6 P52701 R62C 62 R C 0.148 Neutral MSH6 P52701 R62D 62 R D 0.18 Neutral MSH6 P52701 R62E 62 R E 0.02 Neutral MSH6 P52701 R62F 62 R F 0.27 Neutral MSH6 P52701 R62G 62 R G 0.006 Neutral MSH6 P52701 R62H 62 R H 0.12 Neutral MSH6 P52701 R62I 62 R I 0.304 Neutral MSH6 P52701 R62K 62 R K 0.004 Neutral MSH6 P52701 R62L 62 R L 0.23 Neutral MSH6 P52701 R62M 62 R M 0.164 Neutral MSH6 P52701 R62N 62 R N 0.176 Neutral MSH6 P52701 R62P 62 R P 0.028 Neutral MSH6 P52701 R62Q 62 R Q 0.16 Neutral MSH6 P52701 R62S 62 R S 0.016 Neutral MSH6 P52701 R62T 62 R T 0.164 Neutral MSH6 P52701 R62V 62 R V 0.056 Neutral MSH6 P52701 R62W 62 R W 0.384 Neutral MSH6 P52701 R62Y 62 R Y 0.284 Neutral MSH6 P52701 G620A 620 G A 0.04 Neutral MSH6 P52701 G620C 620 G C 0.438 Neutral MSH6 P52701 G620D 620 G D 0.708 Pathogenic MSH6 P52701 G620E 620 G E 0.786 Pathogenic MSH6 P52701 G620F 620 G F 0.94 Pathogenic MSH6 P52701 G620H 620 G H 0.55 Pathogenic MSH6 P52701 G620I 620 G I 0.652 Pathogenic MSH6 P52701 G620K 620 G K 0.938 Pathogenic MSH6 P52701 G620L 620 G L 0.914 Pathogenic MSH6 P52701 G620M 620 G M 0.894 Pathogenic MSH6 P52701 G620N 620 G N 0.408 Neutral MSH6 P52701 G620P 620 G P 0.572 Pathogenic MSH6 P52701 G620Q 620 G Q 0.472 Neutral MSH6 P52701 G620R 620 G R 0.592 Pathogenic MSH6 P52701 G620S 620 G S 0.068 Neutral MSH6 P52701 G620T 620 G T 0.524 Pathogenic MSH6 P52701 G620V 620 G V 0.566 Pathogenic MSH6 P52701 G620W 620 G W 0.932 Pathogenic MSH6 P52701 G620Y 620 G Y 0.762 Pathogenic MSH6 P52701 L621A 621 L A 0.048 Neutral MSH6 P52701 L621C 621 L C 0.166 Neutral MSH6 P52701 L621D 621 L D 0.092 Neutral MSH6 P52701 L621E 621 L E 0.432 Neutral MSH6 P52701 L621F 621 L F 0.806 Pathogenic MSH6 P52701 L621G 621 L G 0.572 Pathogenic MSH6 P52701 L621H 621 L H 0.392 Neutral MSH6 P52701 L621I 621 L I 0.23 Neutral MSH6 P52701 L621K 621 L K 0.082 Neutral MSH6 P52701 L621M 621 L M 0.152 Neutral MSH6 P52701 L621N 621 L N 0.084 Neutral MSH6 P52701 L621P 621 L P 0.188 Neutral MSH6 P52701 L621Q 621 L Q 0.192 Neutral MSH6 P52701 L621R 621 L R 0.762 Pathogenic MSH6 P52701 L621S 621 L S 0.046 Neutral MSH6 P52701 L621T 621 L T 0.382 Neutral MSH6 P52701 L621V 621 L V 0.048 Neutral MSH6 P52701 L621W 621 L W 0.866 Pathogenic MSH6 P52701 L621Y 621 L Y 0.858 Pathogenic MSH6 P52701 I622A 622 I A 0.05 Neutral MSH6 P52701 I622C 622 I C 0.102 Neutral MSH6 P52701 I622D 622 I D 0.614 Pathogenic MSH6 P52701 I622E 622 I E 0.284 Neutral MSH6 P52701 I622F 622 I F 0.614 Pathogenic MSH6 P52701 I622G 622 I G 0.164 Neutral MSH6 P52701 I622H 622 I H 0.17 Neutral MSH6 P52701 I622K 622 I K 0.142 Neutral MSH6 P52701 I622L 622 I L 0.012 Neutral MSH6 P52701 I622M 622 I M 0.046 Neutral MSH6 P52701 I622N 622 I N 0.156 Neutral MSH6 P52701 I622P 622 I P 0.1 Neutral MSH6 P52701 I622Q 622 I Q 0.15 Neutral MSH6 P52701 I622R 622 I R 0.758 Pathogenic MSH6 P52701 I622S 622 I S 0.108 Neutral MSH6 P52701 I622T 622 I T 0.036 Neutral MSH6 P52701 I622V 622 I V 0.016 Neutral MSH6 P52701 I622W 622 I W 0.806 Pathogenic MSH6 P52701 I622Y 622 I Y 0.794 Pathogenic MSH6 P52701 P623A 623 P A 0.078 Neutral MSH6 P52701 P623C 623 P C 0.518 Pathogenic MSH6 P52701 P623D 623 P D 0.196 Neutral MSH6 P52701 P623E 623 P E 0.346 Neutral MSH6 P52701 P623F 623 P F 0.904 Pathogenic MSH6 P52701 P623G 623 P G 0.25 Neutral MSH6 P52701 P623H 623 P H 0.632 Pathogenic MSH6 P52701 P623I 623 P I 0.174 Neutral MSH6 P52701 P623K 623 P K 0.138 Neutral MSH6 P52701 P623L 623 P L 0.098 Neutral MSH6 P52701 P623M 623 P M 0.614 Pathogenic MSH6 P52701 P623N 623 P N 0.05 Neutral MSH6 P52701 P623Q 623 P Q 0.15 Neutral MSH6 P52701 P623R 623 P R 0.516 Pathogenic MSH6 P52701 P623S 623 P S 0.04 Neutral MSH6 P52701 P623T 623 P T 0.044 Neutral MSH6 P52701 P623V 623 P V 0.336 Neutral MSH6 P52701 P623W 623 P W 0.886 Pathogenic MSH6 P52701 P623Y 623 P Y 0.868 Pathogenic MSH6 P52701 G624A 624 G A 0.468 Neutral MSH6 P52701 G624C 624 G C 0.73 Pathogenic MSH6 P52701 G624D 624 G D 0.498 Neutral MSH6 P52701 G624E 624 G E 0.556 Pathogenic MSH6 P52701 G624F 624 G F 0.66 Pathogenic MSH6 P52701 G624H 624 G H 0.974 Pathogenic MSH6 P52701 G624I 624 G I 0.702 Pathogenic MSH6 P52701 G624K 624 G K 0.604 Pathogenic MSH6 P52701 G624L 624 G L 0.62 Pathogenic MSH6 P52701 G624M 624 G M 0.986 Pathogenic MSH6 P52701 G624N 624 G N 0.512 Pathogenic MSH6 P52701 G624P 624 G P 0.934 Pathogenic MSH6 P52701 G624Q 624 G Q 0.548 Pathogenic MSH6 P52701 G624R 624 G R 0.992 Pathogenic MSH6 P52701 G624S 624 G S 0.124 Neutral MSH6 P52701 G624T 624 G T 0.6 Pathogenic MSH6 P52701 G624V 624 G V 0.616 Pathogenic MSH6 P52701 G624W 624 G W 0.964 Pathogenic MSH6 P52701 G624Y 624 G Y 0.958 Pathogenic MSH6 P52701 S625A 625 S A 0.068 Neutral MSH6 P52701 S625C 625 S C 0.458 Neutral MSH6 P52701 S625D 625 S D 0.498 Neutral MSH6 P52701 S625E 625 S E 0.448 Neutral MSH6 P52701 S625F 625 S F 0.884 Pathogenic MSH6 P52701 S625G 625 S G 0.35 Neutral MSH6 P52701 S625H 625 S H 0.674 Pathogenic MSH6 P52701 S625I 625 S I 0.356 Neutral MSH6 P52701 S625K 625 S K 0.452 Neutral MSH6 P52701 S625L 625 S L 0.614 Pathogenic MSH6 P52701 S625M 625 S M 0.976 Pathogenic MSH6 P52701 S625N 625 S N 0.046 Neutral MSH6 P52701 S625P 625 S P 0.494 Neutral MSH6 P52701 S625Q 625 S Q 0.69 Pathogenic MSH6 P52701 S625R 625 S R 0.482 Neutral MSH6 P52701 S625T 625 S T 0.062 Neutral MSH6 P52701 S625V 625 S V 0.432 Neutral MSH6 P52701 S625W 625 S W 0.682 Pathogenic MSH6 P52701 S625Y 625 S Y 0.932 Pathogenic MSH6 P52701 Q626A 626 Q A 0.128 Neutral MSH6 P52701 Q626C 626 Q C 0.316 Neutral MSH6 P52701 Q626D 626 Q D 0.116 Neutral MSH6 P52701 Q626E 626 Q E 0.03 Neutral MSH6 P52701 Q626F 626 Q F 0.556 Pathogenic MSH6 P52701 Q626G 626 Q G 0.132 Neutral MSH6 P52701 Q626H 626 Q H 0.102 Neutral MSH6 P52701 Q626I 626 Q I 0.87 Pathogenic MSH6 P52701 Q626K 626 Q K 0.204 Neutral MSH6 P52701 Q626L 626 Q L 0.752 Pathogenic MSH6 P52701 Q626M 626 Q M 0.728 Pathogenic MSH6 P52701 Q626N 626 Q N 0.074 Neutral MSH6 P52701 Q626P 626 Q P 0.332 Neutral MSH6 P52701 Q626R 626 Q R 0.276 Neutral MSH6 P52701 Q626S 626 Q S 0.112 Neutral MSH6 P52701 Q626T 626 Q T 0.038 Neutral MSH6 P52701 Q626V 626 Q V 0.826 Pathogenic MSH6 P52701 Q626W 626 Q W 0.93 Pathogenic MSH6 P52701 Q626Y 626 Q Y 0.892 Pathogenic MSH6 P52701 F627A 627 F A 0.246 Neutral MSH6 P52701 F627C 627 F C 0.158 Neutral MSH6 P52701 F627D 627 F D 0.538 Pathogenic MSH6 P52701 F627E 627 F E 0.12 Neutral MSH6 P52701 F627G 627 F G 0.352 Neutral MSH6 P52701 F627H 627 F H 0.018 Neutral MSH6 P52701 F627I 627 F I 0.296 Neutral MSH6 P52701 F627K 627 F K 0.266 Neutral MSH6 P52701 F627L 627 F L 0.022 Neutral MSH6 P52701 F627M 627 F M 0.038 Neutral MSH6 P52701 F627N 627 F N 0.088 Neutral MSH6 P52701 F627P 627 F P 0.594 Pathogenic MSH6 P52701 F627Q 627 F Q 0.51 Pathogenic MSH6 P52701 F627R 627 F R 0.526 Pathogenic MSH6 P52701 F627S 627 F S 0.1 Neutral MSH6 P52701 F627T 627 F T 0.088 Neutral MSH6 P52701 F627V 627 F V 0.044 Neutral MSH6 P52701 F627W 627 F W 0.732 Pathogenic MSH6 P52701 F627Y 627 F Y 0.038 Neutral MSH6 P52701 W628A 628 W A 0.468 Neutral MSH6 P52701 W628C 628 W C 0.2 Neutral MSH6 P52701 W628D 628 W D 0.502 Pathogenic MSH6 P52701 W628E 628 W E 0.814 Pathogenic MSH6 P52701 W628F 628 W F 0.17 Neutral MSH6 P52701 W628G 628 W G 0.462 Neutral MSH6 P52701 W628H 628 W H 0.72 Pathogenic MSH6 P52701 W628I 628 W I 0.56 Pathogenic MSH6 P52701 W628K 628 W K 0.906 Pathogenic MSH6 P52701 W628L 628 W L 0.18 Neutral MSH6 P52701 W628M 628 W M 0.272 Neutral MSH6 P52701 W628N 628 W N 0.472 Neutral MSH6 P52701 W628P 628 W P 0.168 Neutral MSH6 P52701 W628Q 628 W Q 0.624 Pathogenic MSH6 P52701 W628R 628 W R 0.698 Pathogenic MSH6 P52701 W628S 628 W S 0.298 Neutral MSH6 P52701 W628T 628 W T 0.468 Neutral MSH6 P52701 W628V 628 W V 0.472 Neutral MSH6 P52701 W628Y 628 W Y 0.158 Neutral MSH6 P52701 D629A 629 D A 0.332 Neutral MSH6 P52701 D629C 629 D C 0.742 Pathogenic MSH6 P52701 D629E 629 D E 0.19 Neutral MSH6 P52701 D629F 629 D F 0.932 Pathogenic MSH6 P52701 D629G 629 D G 0.17 Neutral MSH6 P52701 D629H 629 D H 0.35 Neutral MSH6 P52701 D629I 629 D I 0.92 Pathogenic MSH6 P52701 D629K 629 D K 0.5 Pathogenic MSH6 P52701 D629L 629 D L 0.906 Pathogenic MSH6 P52701 D629M 629 D M 0.842 Pathogenic MSH6 P52701 D629N 629 D N 0.078 Neutral MSH6 P52701 D629P 629 D P 0.32 Neutral MSH6 P52701 D629Q 629 D Q 0.6 Pathogenic MSH6 P52701 D629R 629 D R 0.826 Pathogenic MSH6 P52701 D629S 629 D S 0.13 Neutral MSH6 P52701 D629T 629 D T 0.164 Neutral MSH6 P52701 D629V 629 D V 0.938 Pathogenic MSH6 P52701 D629W 629 D W 0.944 Pathogenic MSH6 P52701 D629Y 629 D Y 0.936 Pathogenic MSH6 P52701 S63A 63 S A 0.01 Neutral MSH6 P52701 S63C 63 S C 0.032 Neutral MSH6 P52701 S63D 63 S D 0.024 Neutral MSH6 P52701 S63E 63 S E 0.148 Neutral MSH6 P52701 S63F 63 S F 0.276 Neutral MSH6 P52701 S63G 63 S G 0.064 Neutral MSH6 P52701 S63H 63 S H 0.238 Neutral MSH6 P52701 S63I 63 S I 0.026 Neutral MSH6 P52701 S63K 63 S K 0.14 Neutral MSH6 P52701 S63L 63 S L 0.028 Neutral MSH6 P52701 S63M 63 S M 0.332 Neutral MSH6 P52701 S63N 63 S N 0.004 Neutral MSH6 P52701 S63P 63 S P 0.062 Neutral MSH6 P52701 S63Q 63 S Q 0.132 Neutral MSH6 P52701 S63R 63 S R 0.136 Neutral MSH6 P52701 S63T 63 S T 0.176 Neutral MSH6 P52701 S63V 63 S V 0.134 Neutral MSH6 P52701 S63W 63 S W 0.49 Neutral MSH6 P52701 S63Y 63 S Y 0.448 Neutral MSH6 P52701 A630C 630 A C 0.688 Pathogenic MSH6 P52701 A630D 630 A D 0.806 Pathogenic MSH6 P52701 A630E 630 A E 0.832 Pathogenic MSH6 P52701 A630F 630 A F 0.926 Pathogenic MSH6 P52701 A630G 630 A G 0.02 Neutral MSH6 P52701 A630H 630 A H 0.822 Pathogenic MSH6 P52701 A630I 630 A I 0.892 Pathogenic MSH6 P52701 A630K 630 A K 0.866 Pathogenic MSH6 P52701 A630L 630 A L 0.912 Pathogenic MSH6 P52701 A630M 630 A M 0.784 Pathogenic MSH6 P52701 A630N 630 A N 0.736 Pathogenic MSH6 P52701 A630P 630 A P 0.284 Neutral MSH6 P52701 A630Q 630 A Q 0.76 Pathogenic MSH6 P52701 A630R 630 A R 0.876 Pathogenic MSH6 P52701 A630S 630 A S 0.006 Neutral MSH6 P52701 A630T 630 A T 0.38 Neutral MSH6 P52701 A630V 630 A V 0.394 Neutral MSH6 P52701 A630W 630 A W 0.924 Pathogenic MSH6 P52701 A630Y 630 A Y 0.908 Pathogenic MSH6 P52701 S631A 631 S A 0.01 Neutral MSH6 P52701 S631C 631 S C 0.076 Neutral MSH6 P52701 S631D 631 S D 0.008 Neutral MSH6 P52701 S631E 631 S E 0.242 Neutral MSH6 P52701 S631F 631 S F 0.424 Neutral MSH6 P52701 S631G 631 S G 0.002 Neutral MSH6 P52701 S631H 631 S H 0.318 Neutral MSH6 P52701 S631I 631 S I 0.27 Neutral MSH6 P52701 S631K 631 S K 0.26 Neutral MSH6 P52701 S631L 631 S L 0.184 Neutral MSH6 P52701 S631M 631 S M 0.634 Pathogenic MSH6 P52701 S631N 631 S N 0.066 Neutral MSH6 P52701 S631P 631 S P 0.076 Neutral MSH6 P52701 S631Q 631 S Q 0.274 Neutral MSH6 P52701 S631R 631 S R 0.376 Neutral MSH6 P52701 S631T 631 S T 0.02 Neutral MSH6 P52701 S631V 631 S V 0.414 Neutral MSH6 P52701 S631W 631 S W 0.762 Pathogenic MSH6 P52701 S631Y 631 S Y 0.718 Pathogenic MSH6 P52701 K632A 632 K A 0.248 Neutral MSH6 P52701 K632C 632 K C 0.172 Neutral MSH6 P52701 K632D 632 K D 0.016 Neutral MSH6 P52701 K632E 632 K E 0.02 Neutral MSH6 P52701 K632F 632 K F 0.77 Pathogenic MSH6 P52701 K632G 632 K G 0.28 Neutral MSH6 P52701 K632H 632 K H 0.274 Neutral MSH6 P52701 K632I 632 K I 0.82 Pathogenic MSH6 P52701 K632L 632 K L 0.784 Pathogenic MSH6 P52701 K632M 632 K M 0.566 Pathogenic MSH6 P52701 K632N 632 K N 0.062 Neutral MSH6 P52701 K632P 632 K P 0.798 Pathogenic MSH6 P52701 K632Q 632 K Q 0.146 Neutral MSH6 P52701 K632R 632 K R 0.018 Neutral MSH6 P52701 K632S 632 K S 0.528 Pathogenic MSH6 P52701 K632T 632 K T 0.032 Neutral MSH6 P52701 K632V 632 K V 0.726 Pathogenic MSH6 P52701 K632W 632 K W 0.95 Pathogenic MSH6 P52701 K632Y 632 K Y 0.886 Pathogenic MSH6 P52701 T633A 633 T A 0.056 Neutral MSH6 P52701 T633C 633 T C 0.36 Neutral MSH6 P52701 T633D 633 T D 0.574 Pathogenic MSH6 P52701 T633E 633 T E 0.672 Pathogenic MSH6 P52701 T633F 633 T F 0.774 Pathogenic MSH6 P52701 T633G 633 T G 0.128 Neutral MSH6 P52701 T633H 633 T H 0.622 Pathogenic MSH6 P52701 T633I 633 T I 0.61 Pathogenic MSH6 P52701 T633K 633 T K 0.59 Pathogenic MSH6 P52701 T633L 633 T L 0.278 Neutral MSH6 P52701 T633M 633 T M 0.724 Pathogenic MSH6 P52701 T633N 633 T N 0.39 Neutral MSH6 P52701 T633P 633 T P 0.68 Pathogenic MSH6 P52701 T633Q 633 T Q 0.406 Neutral MSH6 P52701 T633R 633 T R 0.858 Pathogenic MSH6 P52701 T633S 633 T S 0.378 Neutral MSH6 P52701 T633V 633 T V 0.06 Neutral MSH6 P52701 T633W 633 T W 0.95 Pathogenic MSH6 P52701 T633Y 633 T Y 0.946 Pathogenic MSH6 P52701 L634A 634 L A 0.28 Neutral MSH6 P52701 L634C 634 L C 0.338 Neutral MSH6 P52701 L634D 634 L D 0.604 Pathogenic MSH6 P52701 L634E 634 L E 0.56 Pathogenic MSH6 P52701 L634F 634 L F 0.784 Pathogenic MSH6 P52701 L634G 634 L G 0.54 Pathogenic MSH6 P52701 L634H 634 L H 0.352 Neutral MSH6 P52701 L634I 634 L I 0.366 Neutral MSH6 P52701 L634K 634 L K 0.438 Neutral MSH6 P52701 L634M 634 L M 0.444 Neutral MSH6 P52701 L634N 634 L N 0.564 Pathogenic MSH6 P52701 L634P 634 L P 0.9 Pathogenic MSH6 P52701 L634Q 634 L Q 0.308 Neutral MSH6 P52701 L634R 634 L R 0.86 Pathogenic MSH6 P52701 L634S 634 L S 0.394 Neutral MSH6 P52701 L634T 634 L T 0.374 Neutral MSH6 P52701 L634V 634 L V 0.424 Neutral MSH6 P52701 L634W 634 L W 0.868 Pathogenic MSH6 P52701 L634Y 634 L Y 0.866 Pathogenic MSH6 P52701 R635A 635 R A 0.428 Neutral MSH6 P52701 R635C 635 R C 0.142 Neutral MSH6 P52701 R635D 635 R D 0.046 Neutral MSH6 P52701 R635E 635 R E 0.074 Neutral MSH6 P52701 R635F 635 R F 0.936 Pathogenic MSH6 P52701 R635G 635 R G 0.046 Neutral MSH6 P52701 R635H 635 R H 0.468 Neutral MSH6 P52701 R635I 635 R I 0.904 Pathogenic MSH6 P52701 R635K 635 R K 0.288 Neutral MSH6 P52701 R635L 635 R L 0.116 Neutral MSH6 P52701 R635M 635 R M 0.3 Neutral MSH6 P52701 R635N 635 R N 0.026 Neutral MSH6 P52701 R635P 635 R P 0.846 Pathogenic MSH6 P52701 R635Q 635 R Q 0.024 Neutral MSH6 P52701 R635S 635 R S 0.058 Neutral MSH6 P52701 R635T 635 R T 0.064 Neutral MSH6 P52701 R635V 635 R V 0.656 Pathogenic MSH6 P52701 R635W 635 R W 0.914 Pathogenic MSH6 P52701 R635Y 635 R Y 0.166 Neutral MSH6 P52701 T636A 636 T A 0.076 Neutral MSH6 P52701 T636C 636 T C 0.442 Neutral MSH6 P52701 T636D 636 T D 0.18 Neutral MSH6 P52701 T636E 636 T E 0.138 Neutral MSH6 P52701 T636F 636 T F 0.422 Neutral MSH6 P52701 T636G 636 T G 0.196 Neutral MSH6 P52701 T636H 636 T H 0.45 Neutral MSH6 P52701 T636I 636 T I 0.112 Neutral MSH6 P52701 T636K 636 T K 0.156 Neutral MSH6 P52701 T636L 636 T L 0.064 Neutral MSH6 P52701 T636M 636 T M 0.15 Neutral MSH6 P52701 T636N 636 T N 0.128 Neutral MSH6 P52701 T636P 636 T P 0.59 Pathogenic MSH6 P52701 T636Q 636 T Q 0.016 Neutral MSH6 P52701 T636R 636 T R 0.428 Neutral MSH6 P52701 T636S 636 T S 0.016 Neutral MSH6 P52701 T636V 636 T V 0.072 Neutral MSH6 P52701 T636W 636 T W 0.914 Pathogenic MSH6 P52701 T636Y 636 T Y 0.894 Pathogenic MSH6 P52701 L637A 637 L A 0.118 Neutral MSH6 P52701 L637C 637 L C 0.64 Pathogenic MSH6 P52701 L637D 637 L D 0.92 Pathogenic MSH6 P52701 L637E 637 L E 0.884 Pathogenic MSH6 P52701 L637F 637 L F 0.452 Neutral MSH6 P52701 L637G 637 L G 0.814 Pathogenic MSH6 P52701 L637H 637 L H 0.154 Neutral MSH6 P52701 L637I 637 L I 0.126 Neutral MSH6 P52701 L637K 637 L K 0.654 Pathogenic MSH6 P52701 L637M 637 L M 0.238 Neutral MSH6 P52701 L637N 637 L N 0.192 Neutral MSH6 P52701 L637P 637 L P 0.948 Pathogenic MSH6 P52701 L637Q 637 L Q 0.564 Pathogenic MSH6 P52701 L637R 637 L R 0.984 Pathogenic MSH6 P52701 L637S 637 L S 0.37 Neutral MSH6 P52701 L637T 637 L T 0.514 Pathogenic MSH6 P52701 L637V 637 L V 0.108 Neutral MSH6 P52701 L637W 637 L W 0.816 Pathogenic MSH6 P52701 L637Y 637 L Y 0.652 Pathogenic MSH6 P52701 L638A 638 L A 0.016 Neutral MSH6 P52701 L638C 638 L C 0.176 Neutral MSH6 P52701 L638D 638 L D 0.048 Neutral MSH6 P52701 L638E 638 L E 0.048 Neutral MSH6 P52701 L638F 638 L F 0.474 Neutral MSH6 P52701 L638G 638 L G 0.228 Neutral MSH6 P52701 L638H 638 L H 0.012 Neutral MSH6 P52701 L638I 638 L I 0.004 Neutral MSH6 P52701 L638K 638 L K 0.03 Neutral MSH6 P52701 L638M 638 L M 0.146 Neutral MSH6 P52701 L638N 638 L N 0.044 Neutral MSH6 P52701 L638P 638 L P 0.51 Pathogenic MSH6 P52701 L638Q 638 L Q 0.072 Neutral MSH6 P52701 L638R 638 L R 0.428 Neutral MSH6 P52701 L638S 638 L S 0.024 Neutral MSH6 P52701 L638T 638 L T 0.026 Neutral MSH6 P52701 L638V 638 L V 0.158 Neutral MSH6 P52701 L638W 638 L W 0.64 Pathogenic MSH6 P52701 L638Y 638 L Y 0.47 Neutral MSH6 P52701 E639A 639 E A 0.172 Neutral MSH6 P52701 E639C 639 E C 0.058 Neutral MSH6 P52701 E639D 639 E D 0.03 Neutral MSH6 P52701 E639F 639 E F 0.446 Neutral MSH6 P52701 E639G 639 E G 0.024 Neutral MSH6 P52701 E639H 639 E H 0.536 Pathogenic MSH6 P52701 E639I 639 E I 0.85 Pathogenic MSH6 P52701 E639K 639 E K 0.028 Neutral MSH6 P52701 E639L 639 E L 0.812 Pathogenic MSH6 P52701 E639M 639 E M 0.664 Pathogenic MSH6 P52701 E639N 639 E N 0.014 Neutral MSH6 P52701 E639P 639 E P 0.84 Pathogenic MSH6 P52701 E639Q 639 E Q 0.018 Neutral MSH6 P52701 E639R 639 E R 0.076 Neutral MSH6 P52701 E639S 639 E S 0.038 Neutral MSH6 P52701 E639T 639 E T 0.334 Neutral MSH6 P52701 E639V 639 E V 0.114 Neutral MSH6 P52701 E639W 639 E W 0.918 Pathogenic MSH6 P52701 E639Y 639 E Y 0.844 Pathogenic MSH6 P52701 A64C 64 A C 0.182 Neutral MSH6 P52701 A64D 64 A D 0.266 Neutral MSH6 P52701 A64E 64 A E 0.306 Neutral MSH6 P52701 A64F 64 A F 0.468 Neutral MSH6 P52701 A64G 64 A G 0.022 Neutral MSH6 P52701 A64H 64 A H 0.304 Neutral MSH6 P52701 A64I 64 A I 0.406 Neutral MSH6 P52701 A64K 64 A K 0.254 Neutral MSH6 P52701 A64L 64 A L 0.414 Neutral MSH6 P52701 A64M 64 A M 0.29 Neutral MSH6 P52701 A64N 64 A N 0.274 Neutral MSH6 P52701 A64P 64 A P 0.3 Neutral MSH6 P52701 A64Q 64 A Q 0.286 Neutral MSH6 P52701 A64R 64 A R 0.36 Neutral MSH6 P52701 A64S 64 A S 0.008 Neutral MSH6 P52701 A64T 64 A T 0.08 Neutral MSH6 P52701 A64V 64 A V 0.202 Neutral MSH6 P52701 A64W 64 A W 0.504 Pathogenic MSH6 P52701 A64Y 64 A Y 0.482 Neutral MSH6 P52701 E640A 640 E A 0.156 Neutral MSH6 P52701 E640C 640 E C 0.08 Neutral MSH6 P52701 E640D 640 E D 0.026 Neutral MSH6 P52701 E640F 640 E F 0.688 Pathogenic MSH6 P52701 E640G 640 E G 0.044 Neutral MSH6 P52701 E640H 640 E H 0.138 Neutral MSH6 P52701 E640I 640 E I 0.792 Pathogenic MSH6 P52701 E640K 640 E K 0.04 Neutral MSH6 P52701 E640L 640 E L 0.124 Neutral MSH6 P52701 E640M 640 E M 0.548 Pathogenic MSH6 P52701 E640N 640 E N 0.028 Neutral MSH6 P52701 E640P 640 E P 0.756 Pathogenic MSH6 P52701 E640Q 640 E Q 0.19 Neutral MSH6 P52701 E640R 640 E R 0.068 Neutral MSH6 P52701 E640S 640 E S 0.066 Neutral MSH6 P52701 E640T 640 E T 0.594 Pathogenic MSH6 P52701 E640V 640 E V 0.714 Pathogenic MSH6 P52701 E640W 640 E W 0.868 Pathogenic MSH6 P52701 E640Y 640 E Y 0.772 Pathogenic MSH6 P52701 E641A 641 E A 0.104 Neutral MSH6 P52701 E641C 641 E C 0.056 Neutral MSH6 P52701 E641D 641 E D 0.008 Neutral MSH6 P52701 E641F 641 E F 0.148 Neutral MSH6 P52701 E641G 641 E G 0.008 Neutral MSH6 P52701 E641H 641 E H 0.318 Neutral MSH6 P52701 E641I 641 E I 0.156 Neutral MSH6 P52701 E641K 641 E K 0.008 Neutral MSH6 P52701 E641L 641 E L 0.262 Neutral MSH6 P52701 E641M 641 E M 0.17 Neutral MSH6 P52701 E641N 641 E N 0.004 Neutral MSH6 P52701 E641P 641 E P 0.504 Pathogenic MSH6 P52701 E641Q 641 E Q 0.054 Neutral MSH6 P52701 E641R 641 E R 0.028 Neutral MSH6 P52701 E641S 641 E S 0.022 Neutral MSH6 P52701 E641T 641 E T 0.324 Neutral MSH6 P52701 E641V 641 E V 0.248 Neutral MSH6 P52701 E641W 641 E W 0.766 Pathogenic MSH6 P52701 E641Y 641 E Y 0.702 Pathogenic MSH6 P52701 Y642A 642 Y A 0.39 Neutral MSH6 P52701 Y642C 642 Y C 0.328 Neutral MSH6 P52701 Y642D 642 Y D 0.788 Pathogenic MSH6 P52701 Y642E 642 Y E 0.696 Pathogenic MSH6 P52701 Y642F 642 Y F 0.154 Neutral MSH6 P52701 Y642G 642 Y G 0.196 Neutral MSH6 P52701 Y642H 642 Y H 0.18 Neutral MSH6 P52701 Y642I 642 Y I 0.756 Pathogenic MSH6 P52701 Y642K 642 Y K 0.8 Pathogenic MSH6 P52701 Y642L 642 Y L 0.236 Neutral MSH6 P52701 Y642M 642 Y M 0.644 Pathogenic MSH6 P52701 Y642N 642 Y N 0.208 Neutral MSH6 P52701 Y642P 642 Y P 0.76 Pathogenic MSH6 P52701 Y642Q 642 Y Q 0.582 Pathogenic MSH6 P52701 Y642R 642 Y R 0.45 Neutral MSH6 P52701 Y642S 642 Y S 0.196 Neutral MSH6 P52701 Y642T 642 Y T 0.316 Neutral MSH6 P52701 Y642V 642 Y V 0.388 Neutral MSH6 P52701 Y642W 642 Y W 0.866 Pathogenic MSH6 P52701 F643A 643 F A 0.472 Neutral MSH6 P52701 F643C 643 F C 0.164 Neutral MSH6 P52701 F643D 643 F D 0.168 Neutral MSH6 P52701 F643E 643 F E 0.834 Pathogenic MSH6 P52701 F643G 643 F G 0.226 Neutral MSH6 P52701 F643H 643 F H 0.694 Pathogenic MSH6 P52701 F643I 643 F I 0.602 Pathogenic MSH6 P52701 F643K 643 F K 0.816 Pathogenic MSH6 P52701 F643L 643 F L 0.12 Neutral MSH6 P52701 F643M 643 F M 0.72 Pathogenic MSH6 P52701 F643N 643 F N 0.246 Neutral MSH6 P52701 F643P 643 F P 0.938 Pathogenic MSH6 P52701 F643Q 643 F Q 0.706 Pathogenic MSH6 P52701 F643R 643 F R 0.902 Pathogenic MSH6 P52701 F643S 643 F S 0.192 Neutral MSH6 P52701 F643T 643 F T 0.576 Pathogenic MSH6 P52701 F643V 643 F V 0.842 Pathogenic MSH6 P52701 F643W 643 F W 0.94 Pathogenic MSH6 P52701 F643Y 643 F Y 0.248 Neutral MSH6 P52701 R644A 644 R A 0.04 Neutral MSH6 P52701 R644C 644 R C 0.23 Neutral MSH6 P52701 R644D 644 R D 0.022 Neutral MSH6 P52701 R644E 644 R E 0.028 Neutral MSH6 P52701 R644F 644 R F 0.452 Neutral MSH6 P52701 R644G 644 R G 0.002 Neutral MSH6 P52701 R644H 644 R H 0.17 Neutral MSH6 P52701 R644I 644 R I 0.482 Neutral MSH6 P52701 R644K 644 R K 0.008 Neutral MSH6 P52701 R644L 644 R L 0.044 Neutral MSH6 P52701 R644M 644 R M 0.246 Neutral MSH6 P52701 R644N 644 R N 0.086 Neutral MSH6 P52701 R644P 644 R P 0.056 Neutral MSH6 P52701 R644Q 644 R Q 0.01 Neutral MSH6 P52701 R644S 644 R S 0.018 Neutral MSH6 P52701 R644T 644 R T 0.02 Neutral MSH6 P52701 R644V 644 R V 0.046 Neutral MSH6 P52701 R644W 644 R W 0.612 Pathogenic MSH6 P52701 R644Y 644 R Y 0.448 Neutral MSH6 P52701 E645A 645 E A 0.076 Neutral MSH6 P52701 E645C 645 E C 0.108 Neutral MSH6 P52701 E645D 645 E D 0.002 Neutral MSH6 P52701 E645F 645 E F 0.42 Neutral MSH6 P52701 E645G 645 E G 0 Neutral MSH6 P52701 E645H 645 E H 0.124 Neutral MSH6 P52701 E645I 645 E I 0.49 Neutral MSH6 P52701 E645K 645 E K 0.002 Neutral MSH6 P52701 E645L 645 E L 0.062 Neutral MSH6 P52701 E645M 645 E M 0.278 Neutral MSH6 P52701 E645N 645 E N 0.002 Neutral MSH6 P52701 E645P 645 E P 0.064 Neutral MSH6 P52701 E645Q 645 E Q 0.018 Neutral MSH6 P52701 E645R 645 E R 0.02 Neutral MSH6 P52701 E645S 645 E S 0.02 Neutral MSH6 P52701 E645T 645 E T 0.012 Neutral MSH6 P52701 E645V 645 E V 0.374 Neutral MSH6 P52701 E645W 645 E W 0.694 Pathogenic MSH6 P52701 E645Y 645 E Y 0.58 Pathogenic MSH6 P52701 K646A 646 K A 0.028 Neutral MSH6 P52701 K646C 646 K C 0.046 Neutral MSH6 P52701 K646D 646 K D 0.002 Neutral MSH6 P52701 K646E 646 K E 0.004 Neutral MSH6 P52701 K646F 646 K F 0.212 Neutral MSH6 P52701 K646G 646 K G 0.042 Neutral MSH6 P52701 K646H 646 K H 0.01 Neutral MSH6 P52701 K646I 646 K I 0.19 Neutral MSH6 P52701 K646L 646 K L 0.104 Neutral MSH6 P52701 K646M 646 K M 0.146 Neutral MSH6 P52701 K646N 646 K N 0.006 Neutral MSH6 P52701 K646P 646 K P 0.01 Neutral MSH6 P52701 K646Q 646 K Q 0.006 Neutral MSH6 P52701 K646R 646 K R 0.056 Neutral MSH6 P52701 K646S 646 K S 0.012 Neutral MSH6 P52701 K646T 646 K T 0.014 Neutral MSH6 P52701 K646V 646 K V 0.024 Neutral MSH6 P52701 K646W 646 K W 0.396 Neutral MSH6 P52701 K646Y 646 K Y 0.324 Neutral MSH6 P52701 L647A 647 L A 0.008 Neutral MSH6 P52701 L647C 647 L C 0.094 Neutral MSH6 P52701 L647D 647 L D 0.038 Neutral MSH6 P52701 L647E 647 L E 0.03 Neutral MSH6 P52701 L647F 647 L F 0.204 Neutral MSH6 P52701 L647G 647 L G 0.052 Neutral MSH6 P52701 L647H 647 L H 0.04 Neutral MSH6 P52701 L647I 647 L I 0.03 Neutral MSH6 P52701 L647K 647 L K 0.02 Neutral MSH6 P52701 L647M 647 L M 0.132 Neutral MSH6 P52701 L647N 647 L N 0.028 Neutral MSH6 P52701 L647P 647 L P 0.088 Neutral MSH6 P52701 L647Q 647 L Q 0.004 Neutral MSH6 P52701 L647R 647 L R 0.28 Neutral MSH6 P52701 L647S 647 L S 0.01 Neutral MSH6 P52701 L647T 647 L T 0.01 Neutral MSH6 P52701 L647V 647 L V 0.016 Neutral MSH6 P52701 L647W 647 L W 0.334 Neutral MSH6 P52701 L647Y 647 L Y 0.282 Neutral MSH6 P52701 S648A 648 S A 0.018 Neutral MSH6 P52701 S648C 648 S C 0.032 Neutral MSH6 P52701 S648D 648 S D 0.002 Neutral MSH6 P52701 S648E 648 S E 0.138 Neutral MSH6 P52701 S648F 648 S F 0.264 Neutral MSH6 P52701 S648G 648 S G 0 Neutral MSH6 P52701 S648H 648 S H 0.188 Neutral MSH6 P52701 S648I 648 S I 0.196 Neutral MSH6 P52701 S648K 648 S K 0.166 Neutral MSH6 P52701 S648L 648 S L 0.028 Neutral MSH6 P52701 S648M 648 S M 0.332 Neutral MSH6 P52701 S648N 648 S N 0.002 Neutral MSH6 P52701 S648P 648 S P 0.062 Neutral MSH6 P52701 S648Q 648 S Q 0.186 Neutral MSH6 P52701 S648R 648 S R 0.138 Neutral MSH6 P52701 S648T 648 S T 0.176 Neutral MSH6 P52701 S648V 648 S V 0.248 Neutral MSH6 P52701 S648W 648 S W 0.49 Neutral MSH6 P52701 S648Y 648 S Y 0.414 Neutral MSH6 P52701 D649A 649 D A 0.014 Neutral MSH6 P52701 D649C 649 D C 0.17 Neutral MSH6 P52701 D649E 649 D E 0.01 Neutral MSH6 P52701 D649F 649 D F 0.37 Neutral MSH6 P52701 D649G 649 D G 0.018 Neutral MSH6 P52701 D649H 649 D H 0.056 Neutral MSH6 P52701 D649I 649 D I 0.116 Neutral MSH6 P52701 D649K 649 D K 0.112 Neutral MSH6 P52701 D649L 649 D L 0.262 Neutral MSH6 P52701 D649M 649 D M 0.106 Neutral MSH6 P52701 D649N 649 D N 0 Neutral MSH6 P52701 D649P 649 D P 0.066 Neutral MSH6 P52701 D649Q 649 D Q 0.078 Neutral MSH6 P52701 D649R 649 D R 0.152 Neutral MSH6 P52701 D649S 649 D S 0.002 Neutral MSH6 P52701 D649T 649 D T 0.014 Neutral MSH6 P52701 D649V 649 D V 0.062 Neutral MSH6 P52701 D649W 649 D W 0.434 Neutral MSH6 P52701 D649Y 649 D Y 0.404 Neutral MSH6 P52701 S65A 65 S A 0.01 Neutral MSH6 P52701 S65C 65 S C 0.032 Neutral MSH6 P52701 S65D 65 S D 0.044 Neutral MSH6 P52701 S65E 65 S E 0.124 Neutral MSH6 P52701 S65F 65 S F 0.276 Neutral MSH6 P52701 S65G 65 S G 0.036 Neutral MSH6 P52701 S65H 65 S H 0.238 Neutral MSH6 P52701 S65I 65 S I 0.026 Neutral MSH6 P52701 S65K 65 S K 0.148 Neutral MSH6 P52701 S65L 65 S L 0.028 Neutral 2 MSH6 P52701 S65M 65 S M 0.332 Neutral MSH6 P52701 S65N 65 S N 0.034 Neutral MSH6 P52701 S65P 65 S P 0.098 Neutral MSH6 P52701 S65Q 65 S Q 0.16 Neutral MSH6 P52701 S65R 65 S R 0.17 Neutral MSH6 P52701 S65T 65 S T 0.046 Neutral MSH6 P52701 S65V 65 S V 0.134 Neutral MSH6 P52701 S65W 65 S W 0.49 Neutral MSH6 P52701 S65Y 65 S Y 0.448 Neutral MSH6 P52701 G650A 650 G A 0.002 Neutral MSH6 P52701 G650C 650 G C 0.132 Neutral MSH6 P52701 G650D 650 G D 0.134 Neutral MSH6 P52701 G650E 650 G E 0.192 Neutral MSH6 P52701 G650F 650 G F 0.498 Neutral MSH6 P52701 G650H 650 G H 0.442 Neutral MSH6 P52701 G650I 650 G I 0.412 Neutral MSH6 P52701 G650K 650 G K 0.27 Neutral MSH6 P52701 G650L 650 G L 0.412 Neutral MSH6 P52701 G650M 650 G M 0.422 Neutral MSH6 P52701 G650N 650 G N 0.178 Neutral MSH6 P52701 G650P 650 G P 0.442 Neutral MSH6 P52701 G650Q 650 G Q 0.18 Neutral MSH6 P52701 G650R 650 G R 0.362 Neutral MSH6 P52701 G650S 650 G S 0.01 Neutral MSH6 P52701 G650T 650 G T 0.252 Neutral MSH6 P52701 G650V 650 G V 0.344 Neutral MSH6 P52701 G650W 650 G W 0.498 Neutral MSH6 P52701 G650Y 650 G Y 0.5 Pathogenic MSH6 P52701 I651A 651 I A 0.006 Neutral MSH6 P52701 I651C 651 I C 0.09 Neutral MSH6 P52701 I651D 651 I D 0.028 Neutral MSH6 P52701 I651E 651 I E 0.03 Neutral MSH6 P52701 I651F 651 I F 0.216 Neutral MSH6 P52701 I651G 651 I G 0.106 Neutral MSH6 P52701 I651H 651 I H 0.08 Neutral MSH6 P52701 I651K 651 I K 0.048 Neutral MSH6 P52701 I651L 651 I L 0.11 Neutral MSH6 P52701 I651M 651 I M 0.114 Neutral MSH6 P52701 I651N 651 I N 0.096 Neutral MSH6 P52701 I651P 651 I P 0.178 Neutral MSH6 P52701 I651Q 651 I Q 0.202 Neutral MSH6 P52701 I651R 651 I R 0.274 Neutral MSH6 P52701 I651S 651 I S 0.072 Neutral MSH6 P52701 I651T 651 I T 0.092 Neutral MSH6 P52701 I651V 651 I V 0.122 Neutral MSH6 P52701 I651W 651 I W 0.354 Neutral MSH6 P52701 I651Y 651 I Y 0.31 Neutral MSH6 P52701 G652A 652 G A 0.002 Neutral MSH6 P52701 G652C 652 G C 0.14 Neutral MSH6 P52701 G652D 652 G D 0.118 Neutral MSH6 P52701 G652E 652 G E 0.166 Neutral MSH6 P52701 G652F 652 G F 0.388 Neutral MSH6 P52701 G652H 652 G H 0.442 Neutral MSH6 P52701 G652I 652 G I 0.412 Neutral MSH6 P52701 G652K 652 G K 0.27 Neutral MSH6 P52701 G652L 652 G L 0.338 Neutral MSH6 P52701 G652M 652 G M 0.34 Neutral MSH6 P52701 G652N 652 G N 0.18 Neutral MSH6 P52701 G652P 652 G P 0.364 Neutral MSH6 P52701 G652Q 652 G Q 0.262 Neutral MSH6 P52701 G652R 652 G R 0.304 Neutral MSH6 P52701 G652S 652 G S 0.016 Neutral MSH6 P52701 G652T 652 G T 0.284 Neutral MSH6 P52701 G652V 652 G V 0.318 Neutral MSH6 P52701 G652W 652 G W 0.498 Neutral MSH6 P52701 G652Y 652 G Y 0.5 Pathogenic MSH6 P52701 V653A 653 V A 0 Neutral MSH6 P52701 V653C 653 V C 0.008 Neutral MSH6 P52701 V653D 653 V D 0.028 Neutral MSH6 P52701 V653E 653 V E 0.042 Neutral MSH6 P52701 V653F 653 V F 0.166 Neutral MSH6 P52701 V653G 653 V G 0.038 Neutral MSH6 P52701 V653H 653 V H 0.048 Neutral MSH6 P52701 V653I 653 V I 0.038 Neutral MSH6 P52701 V653K 653 V K 0.116 Neutral MSH6 P52701 V653L 653 V L 0 Neutral MSH6 P52701 V653M 653 V M 0.076 Neutral MSH6 P52701 V653N 653 V N 0.038 Neutral MSH6 P52701 V653P 653 V P 0.088 Neutral MSH6 P52701 V653Q 653 V Q 0.216 Neutral MSH6 P52701 V653R 653 V R 0.228 Neutral MSH6 P52701 V653S 653 V S 0.01 Neutral MSH6 P52701 V653T 653 V T 0.008 Neutral MSH6 P52701 V653W 653 V W 0.344 Neutral MSH6 P52701 V653Y 653 V Y 0.18 Neutral MSH6 P52701 M654A 654 M A 0.046 Neutral MSH6 P52701 M654C 654 M C 0 Neutral MSH6 P52701 M654D 654 M D 0.074 Neutral MSH6 P52701 M654E 654 M E 0.008 Neutral MSH6 P52701 M654F 654 M F 0.038 Neutral MSH6 P52701 M654G 654 M G 0.04 Neutral MSH6 P52701 M654H 654 M H 0.022 Neutral MSH6 P52701 M654I 654 M I 0.004 Neutral MSH6 P52701 M654K 654 M K 0.06 Neutral MSH6 P52701 M654L 654 M L 0.004 Neutral MSH6 P52701 M654N 654 M N 0.052 Neutral MSH6 P52701 M654P 654 M P 0.262 Neutral MSH6 P52701 M654Q 654 M Q 0.006 Neutral MSH6 P52701 M654R 654 M R 0.042 Neutral MSH6 P52701 M654S 654 M S 0.012 Neutral MSH6 P52701 M654T 654 M T 0.008 Neutral MSH6 P52701 M654V 654 M V 0.016 Neutral MSH6 P52701 M654W 654 M W 0.422 Neutral MSH6 P52701 M654Y 654 M Y 0.218 Neutral MSH6 P52701 L655A 655 L A 0.306 Neutral MSH6 P52701 L655C 655 L C 0.392 Neutral MSH6 P52701 L655D 655 L D 0.512 Pathogenic MSH6 P52701 L655E 655 L E 0.622 Pathogenic MSH6 P52701 L655F 655 L F 0.738 Pathogenic MSH6 P52701 L655G 655 L G 0.58 Pathogenic MSH6 P52701 L655H 655 L H 0.162 Neutral MSH6 P52701 L655I 655 L I 0.578 Pathogenic MSH6 P52701 L655K 655 L K 0.48 Neutral MSH6 P52701 L655M 655 L M 0.052 Neutral MSH6 P52701 L655N 655 L N 0.614 Pathogenic MSH6 P52701 L655P 655 L P 0.574 Pathogenic MSH6 P52701 L655Q 655 L Q 0.36 Neutral MSH6 P52701 L655R 655 L R 0.866 Pathogenic MSH6 P52701 L655S 655 L S 0.4 Neutral MSH6 P52701 L655T 655 L T 0.382 Neutral MSH6 P52701 L655V 655 L V 0.426 Neutral MSH6 P52701 L655W 655 L W 0.536 Pathogenic MSH6 P52701 L655Y 655 L Y 0.728 Pathogenic MSH6 P52701 P656A 656 P A 0.828 Pathogenic MSH6 P52701 P656C 656 P C 0.912 Pathogenic MSH6 P52701 P656D 656 P D 0.864 Pathogenic MSH6 P52701 P656E 656 P E 0.734 Pathogenic MSH6 P52701 P656F 656 P F 0.998 Pathogenic MSH6 P52701 P656G 656 P G 0.69 Pathogenic MSH6 P52701 P656H 656 P H 0.974 Pathogenic MSH6 P52701 P656I 656 P I 0.936 Pathogenic MSH6 P52701 P656K 656 P K 0.944 Pathogenic MSH6 P52701 P656L 656 P L 0.676 Pathogenic MSH6 P52701 P656M 656 P M 0.954 Pathogenic MSH6 P52701 P656N 656 P N 0.784 Pathogenic MSH6 P52701 P656Q 656 P Q 0.876 Pathogenic MSH6 P52701 P656R 656 P R 0.982 Pathogenic MSH6 P52701 P656S 656 P S 0.366 Neutral MSH6 P52701 P656T 656 P T 0.54 Pathogenic MSH6 P52701 P656V 656 P V 0.838 Pathogenic MSH6 P52701 P656W 656 P W 0.93 Pathogenic MSH6 P52701 P656Y 656 P Y 0.926 Pathogenic MSH6 P52701 Q657A 657 Q A 0.1 Neutral MSH6 P52701 Q657C 657 Q C 0.348 Neutral MSH6 P52701 Q657D 657 Q D 0.018 Neutral MSH6 P52701 Q657E 657 Q E 0.026 Neutral MSH6 P52701 Q657F 657 Q F 0.756 Pathogenic MSH6 P52701 Q657G 657 Q G 0.354 Neutral MSH6 P52701 Q657H 657 Q H 0.198 Neutral MSH6 P52701 Q657I 657 Q I 0.552 Pathogenic MSH6 P52701 Q657K 657 Q K 0.042 Neutral MSH6 P52701 Q657L 657 Q L 0.166 Neutral MSH6 P52701 Q657M 657 Q M 0.666 Pathogenic MSH6 P52701 Q657N 657 Q N 0.146 Neutral MSH6 P52701 Q657P 657 Q P 0.302 Neutral MSH6 P52701 Q657R 657 Q R 0.41 Neutral MSH6 P52701 Q657S 657 Q S 0.076 Neutral MSH6 P52701 Q657T 657 Q T 0.02 Neutral MSH6 P52701 Q657V 657 Q V 0.108 Neutral MSH6 P52701 Q657W 657 Q W 0.886 Pathogenic MSH6 P52701 Q657Y 657 Q Y 0.836 Pathogenic MSH6 P52701 V658A 658 V A 0.012 Neutral MSH6 P52701 V658C 658 V C 0.256 Neutral MSH6 P52701 V658D 658 V D 0.066 Neutral MSH6 P52701 V658E 658 V E 0.154 Neutral MSH6 P52701 V658F 658 V F 0.744 Pathogenic MSH6 P52701 V658G 658 V G 0.088 Neutral MSH6 P52701 V658H 658 V H 0.516 Pathogenic MSH6 P52701 V658I 658 V I 0.06 Neutral MSH6 P52701 V658K 658 V K 0.202 Neutral MSH6 P52701 V658L 658 V L 0.048 Neutral MSH6 P52701 V658M 658 V M 0.07 Neutral MSH6 P52701 V658N 658 V N 0.518 Pathogenic MSH6 P52701 V658P 658 V P 0.218 Neutral MSH6 P52701 V658Q 658 V Q 0.164 Neutral MSH6 P52701 V658R 658 V R 0.836 Pathogenic MSH6 P52701 V658S 658 V S 0.282 Neutral MSH6 P52701 V658T 658 V T 0.026 Neutral MSH6 P52701 V658W 658 V W 0.822 Pathogenic MSH6 P52701 V658Y 658 V Y 0.814 Pathogenic MSH6 P52701 L659A 659 L A 0.706 Pathogenic MSH6 P52701 L659C 659 L C 0.82 Pathogenic MSH6 P52701 L659D 659 L D 0.888 Pathogenic MSH6 P52701 L659E 659 L E 0.868 Pathogenic MSH6 P52701 L659F 659 L F 0.474 Neutral MSH6 P52701 L659G 659 L G 0.828 Pathogenic MSH6 P52701 L659H 659 L H 0.908 Pathogenic MSH6 P52701 L659I 659 L I 0.218 Neutral MSH6 P52701 L659K 659 L K 0.724 Pathogenic MSH6 P52701 L659M 659 L M 0.164 Neutral MSH6 P52701 L659N 659 L N 0.764 Pathogenic MSH6 P52701 L659P 659 L P 0.994 Pathogenic MSH6 P52701 L659Q 659 L Q 0.732 Pathogenic MSH6 P52701 L659R 659 L R 0.978 Pathogenic MSH6 P52701 L659S 659 L S 0.646 Pathogenic MSH6 P52701 L659T 659 L T 0.602 Pathogenic MSH6 P52701 L659V 659 L V 0.062 Neutral MSH6 P52701 L659W 659 L W 0.892 Pathogenic MSH6 P52701 L659Y 659 L Y 0.88 Pathogenic MSH6 P52701 P66A 66 P A 0.116 Neutral MSH6 P52701 P66C 66 P C 0.148 Neutral MSH6 P52701 P66D 66 P D 0.078 Neutral MSH6 P52701 P66E 66 P E 0.106 Neutral MSH6 P52701 P66F 66 P F 0.272 Neutral MSH6 P52701 P66G 66 P G 0.066 Neutral MSH6 P52701 P66H 66 P H 0.266 Neutral MSH6 P52701 P66I 66 P I 0.104 Neutral MSH6 P52701 P66K 66 P K 0.1 Neutral MSH6 P52701 P66L 66 P L 0.108 Neutral MSH6 P52701 P66M 66 P M 0.22 Neutral MSH6 P52701 P66N 66 P N 0.018 Neutral MSH6 P52701 P66Q 66 P Q 0.212 Neutral MSH6 P52701 P66R 66 P R 0.306 Neutral MSH6 P52701 P66S 66 P S 0.092 Neutral MSH6 P52701 P66T 66 P T 0.188 Neutral MSH6 P52701 P66V 66 P V 0.184 Neutral MSH6 P52701 P66W 66 P W 0.39 Neutral MSH6 P52701 P66Y 66 P Y 0.32 Neutral MSH6 P52701 K660A 660 K A 0.112 Neutral MSH6 P52701 K660C 660 K C 0.106 Neutral MSH6 P52701 K660D 660 K D 0.148 Neutral MSH6 P52701 K660E 660 K E 0.018 Neutral MSH6 P52701 K660F 660 K F 0.818 Pathogenic MSH6 P52701 K660G 660 K G 0.324 Neutral MSH6 P52701 K660H 660 K H 0.158 Neutral MSH6 P52701 K660I 660 K I 0.856 Pathogenic MSH6 P52701 K660L 660 K L 0.086 Neutral MSH6 P52701 K660M 660 K M 0.622 Pathogenic MSH6 P52701 K660N 660 K N 0.16 Neutral MSH6 P52701 K660P 660 K P 0.806 Pathogenic MSH6 P52701 K660Q 660 K Q 0.024 Neutral MSH6 P52701 K660R 660 K R 0.028 Neutral MSH6 P52701 K660S 660 K S 0.032 Neutral MSH6 P52701 K660T 660 K T 0.072 Neutral MSH6 P52701 K660V 660 K V 0.224 Neutral MSH6 P52701 K660W 660 K W 0.976 Pathogenic MSH6 P52701 K660Y 660 K Y 0.876 Pathogenic MSH6 P52701 G661A 661 G A 0.008 Neutral MSH6 P52701 G661C 661 G C 0.276 Neutral MSH6 P52701 G661D 661 G D 0.224 Neutral MSH6 P52701 G661E 661 G E 0.3 Neutral MSH6 P52701 G661F 661 G F 0.772 Pathogenic MSH6 P52701 G661H 661 G H 0.42 Neutral MSH6 P52701 G661I 661 G I 0.706 Pathogenic MSH6 P52701 G661K 661 G K 0.392 Neutral MSH6 P52701 G661L 661 G L 0.69 Pathogenic MSH6 P52701 G661M 661 G M 0.618 Pathogenic MSH6 P52701 G661N 661 G N 0.26 Neutral MSH6 P52701 G661P 661 G P 0.458 Neutral MSH6 P52701 G661Q 661 G Q 0.296 Neutral MSH6 P52701 G661R 661 G R 0.404 Neutral MSH6 P52701 G661S 661 G S 0.03 Neutral MSH6 P52701 G661T 661 G T 0.358 Neutral MSH6 P52701 G661V 661 G V 0.496 Neutral MSH6 P52701 G661W 661 G W 0.77 Pathogenic MSH6 P52701 G661Y 661 G Y 0.598 Pathogenic MSH6 P52701 M662A 662 M A 0.306 Neutral MSH6 P52701 M662C 662 M C 0.186 Neutral MSH6 P52701 M662D 662 M D 0.574 Pathogenic MSH6 P52701 M662E 662 M E 0.174 Neutral MSH6 P52701 M662F 662 M F 0.064 Neutral MSH6 P52701 M662G 662 M G 0.314 Neutral MSH6 P52701 M662H 662 M H 0.262 Neutral MSH6 P52701 M662I 662 M I 0.074 Neutral MSH6 P52701 M662K 662 M K 0.546 Pathogenic MSH6 P52701 M662L 662 M L 0.052 Neutral MSH6 P52701 M662N 662 M N 0.592 Pathogenic MSH6 P52701 M662P 662 M P 0.852 Pathogenic MSH6 P52701 M662Q 662 M Q 0.26 Neutral MSH6 P52701 M662R 662 M R 0.588 Pathogenic MSH6 P52701 M662S 662 M S 0.51 Pathogenic MSH6 P52701 M662T 662 M T 0.556 Pathogenic MSH6 P52701 M662V 662 M V 0.066 Neutral MSH6 P52701 M662W 662 M W 0.896 Pathogenic MSH6 P52701 M662Y 662 M Y 0.174 Neutral MSH6 P52701 T663A 663 T A 0.316 Neutral MSH6 P52701 T663C 663 T C 0.348 Neutral MSH6 P52701 T663D 663 T D 0.362 Neutral MSH6 P52701 T663E 663 T E 0.444 Neutral MSH6 P52701 T663F 663 T F 0.62 Pathogenic MSH6 P52701 T663G 663 T G 0.278 Neutral MSH6 P52701 T663H 663 T H 0.448 Neutral MSH6 P52701 T663I 663 T I 0.076 Neutral MSH6 P52701 T663K 663 T K 0.23 Neutral MSH6 P52701 T663L 663 T L 0.056 Neutral MSH6 P52701 T663M 663 T M 0.454 Neutral MSH6 P52701 T663N 663 T N 0.28 Neutral MSH6 P52701 T663P 663 T P 0.494 Neutral MSH6 P52701 T663Q 663 T Q 0.032 Neutral MSH6 P52701 T663R 663 T R 0.588 Pathogenic MSH6 P52701 T663S 663 T S 0.216 Neutral MSH6 P52701 T663V 663 T V 0.054 Neutral MSH6 P52701 T663W 663 T W 0.88 Pathogenic MSH6 P52701 T663Y 663 T Y 0.864 Pathogenic MSH6 P52701 S664A 664 S A 0.01 Neutral MSH6 P52701 S664C 664 S C 0.076 Neutral MSH6 P52701 S664D 664 S D 0.006 Neutral MSH6 P52701 S664E 664 S E 0.222 Neutral MSH6 P52701 S664F 664 S F 0.532 Pathogenic MSH6 P52701 S664G 664 S G 0.026 Neutral MSH6 P52701 S664H 664 S H 0.39 Neutral MSH6 P52701 S664I 664 S I 0.184 Neutral MSH6 P52701 S664K 664 S K 0.34 Neutral MSH6 P52701 S664L 664 S L 0.212 Neutral MSH6 P52701 S664M 664 S M 0.634 Pathogenic MSH6 P52701 S664N 664 S N 0.006 Neutral MSH6 P52701 S664P 664 S P 0.224 Neutral MSH6 P52701 S664Q 664 S Q 0.318 Neutral MSH6 P52701 S664R 664 S R 0.45 Neutral MSH6 P52701 S664T 664 S T 0.302 Neutral MSH6 P52701 S664V 664 S V 0.482 Neutral MSH6 P52701 S664W 664 S W 0.762 Pathogenic MSH6 P52701 S664Y 664 S Y 0.718 Pathogenic MSH6 P52701 E665A 665 E A 0.326 Neutral MSH6 P52701 E665C 665 E C 0.152 Neutral MSH6 P52701 E665D 665 E D 0.004 Neutral MSH6 P52701 E665F 665 E F 0.49 Neutral MSH6 P52701 E665G 665 E G 0.178 Neutral MSH6 P52701 E665H 665 E H 0.25 Neutral MSH6 P52701 E665I 665 E I 0.582 Pathogenic MSH6 P52701 E665K 665 E K 0.018 Neutral MSH6 P52701 E665L 665 E L 0.558 Pathogenic MSH6 P52701 E665M 665 E M 0.358 Neutral MSH6 P52701 E665N 665 E N 0.124 Neutral MSH6 P52701 E665P 665 E P 0.08 Neutral MSH6 P52701 E665Q 665 E Q 0.012 Neutral MSH6 P52701 E665R 665 E R 0.148 Neutral MSH6 P52701 E665S 665 E S 0.362 Neutral MSH6 P52701 E665T 665 E T 0.292 Neutral MSH6 P52701 E665V 665 E V 0.474 Neutral MSH6 P52701 E665W 665 E W 0.772 Pathogenic MSH6 P52701 E665Y 665 E Y 0.644 Pathogenic MSH6 P52701 S666A 666 S A 0.01 Neutral MSH6 P52701 S666C 666 S C 0.04 Neutral MSH6 P52701 S666D 666 S D 0.02 Neutral MSH6 P52701 S666E 666 S E 0.236 Neutral MSH6 P52701 S666F 666 S F 0.52 Pathogenic MSH6 P52701 S666G 666 S G 0.002 Neutral MSH6 P52701 S666H 666 S H 0.29 Neutral MSH6 P52701 S666I 666 S I 0.258 Neutral MSH6 P52701 S666K 666 S K 0.328 Neutral MSH6 P52701 S666L 666 S L 0.204 Neutral MSH6 P52701 S666M 666 S M 0.382 Neutral MSH6 P52701 S666N 666 S N 0.008 Neutral MSH6 P52701 S666P 666 S P 0.214 Neutral MSH6 P52701 S666Q 666 S Q 0.28 Neutral MSH6 P52701 S666R 666 S R 0.446 Neutral MSH6 P52701 S666T 666 S T 0.024 Neutral MSH6 P52701 S666V 666 S V 0.052 Neutral MSH6 P52701 S666W 666 S W 0.744 Pathogenic MSH6 P52701 S666Y 666 S Y 0.684 Pathogenic MSH6 P52701 D667A 667 D A 0.488 Neutral MSH6 P52701 D667C 667 D C 0.7 Pathogenic MSH6 P52701 D667E 667 D E 0.616 Pathogenic MSH6 P52701 D667F 667 D F 0.902 Pathogenic MSH6 P52701 D667G 667 D G 0.462 Neutral MSH6 P52701 D667H 667 D H 0.42 Neutral MSH6 P52701 D667I 667 D I 0.862 Pathogenic MSH6 P52701 D667K 667 D K 0.758 Pathogenic MSH6 P52701 D667L 667 D L 0.852 Pathogenic MSH6 P52701 D667M 667 D M 0.178 Neutral MSH6 P52701 D667N 667 D N 0.168 Neutral MSH6 P52701 D667P 667 D P 0.782 Pathogenic MSH6 P52701 D667Q 667 D Q 0.456 Neutral MSH6 P52701 D667R 667 D R 0.7 Pathogenic MSH6 P52701 D667S 667 D S 0.05 Neutral MSH6 P52701 D667T 667 D T 0.574 Pathogenic MSH6 P52701 D667V 667 D V 0.844 Pathogenic MSH6 P52701 D667W 667 D W 0.954 Pathogenic MSH6 P52701 D667Y 667 D Y 0.946 Pathogenic MSH6 P52701 S668A 668 S A 0.01 Neutral MSH6 P52701 S668C 668 S C 0.076 Neutral MSH6 P52701 S668D 668 S D 0.006 Neutral MSH6 P52701 S668E 668 S E 0.32 Neutral MSH6 P52701 S668F 668 S F 0.564 Pathogenic MSH6 P52701 S668G 668 S G 0.12 Neutral MSH6 P52701 S668H 668 S H 0.298 Neutral MSH6 P52701 S668I 668 S I 0.274 Neutral MSH6 P52701 S668K 668 S K 0.402 Neutral MSH6 P52701 S668L 668 S L 0.136 Neutral MSH6 P52701 S668M 668 S M 0.66 Pathogenic MSH6 P52701 S668N 668 S N 0.074 Neutral MSH6 P52701 S668P 668 S P 0.076 Neutral MSH6 P52701 S668Q 668 S Q 0.348 Neutral MSH6 P52701 S668R 668 S R 0.262 Neutral MSH6 P52701 S668T 668 S T 0.02 Neutral MSH6 P52701 S668V 668 S V 0.482 Neutral MSH6 P52701 S668W 668 S W 0.78 Pathogenic MSH6 P52701 S668Y 668 S Y 0.74 Pathogenic MSH6 P52701 I669A 669 I A 0.016 Neutral MSH6 P52701 I669C 669 I C 0.172 Neutral MSH6 P52701 I669D 669 I D 0.04 Neutral MSH6 P52701 I669E 669 I E 0.042 Neutral MSH6 P52701 I669F 669 I F 0.412 Neutral MSH6 P52701 I669G 669 I G 0.25 Neutral MSH6 P52701 I669H 669 I H 0.164 Neutral MSH6 P52701 I669K 669 I K 0.058 Neutral MSH6 P52701 I669L 669 I L 0.05 Neutral MSH6 P52701 I669M 669 I M 0.132 Neutral MSH6 P52701 I669N 669 I N 0.136 Neutral MSH6 P52701 I669P 669 I P 0.326 Neutral MSH6 P52701 I669Q 669 I Q 0.278 Neutral MSH6 P52701 I669R 669 I R 0.56 Pathogenic MSH6 P52701 I669S 669 I S 0.388 Neutral MSH6 P52701 I669T 669 I T 0.04 Neutral MSH6 P52701 I669V 669 I V 0.036 Neutral MSH6 P52701 I669W 669 I W 0.62 Pathogenic MSH6 P52701 I669Y 669 I Y 0.578 Pathogenic MSH6 P52701 P67A 67 P A 0.176 Neutral MSH6 P52701 P67C 67 P C 0.148 Neutral MSH6 P52701 P67D 67 P D 0.078 Neutral MSH6 P52701 P67E 67 P E 0.214 Neutral MSH6 P52701 P67F 67 P F 0.272 Neutral MSH6 P52701 P67G 67 P G 0.01 Neutral MSH6 P52701 P67H 67 P H 0.266 Neutral MSH6 P52701 P67I 67 P I 0.1 Neutral MSH6 P52701 P67K 67 P K 0.06 Neutral MSH6 P52701 P67L 67 P L 0.094 Neutral MSH6 P52701 P67M 67 P M 0.22 Neutral MSH6 P52701 P67N 67 P N 0.018 Neutral MSH6 P52701 P67Q 67 P Q 0.15 Neutral MSH6 P52701 P67R 67 P R 0.214 Neutral MSH6 P52701 P67S 67 P S 0.002 Neutral MSH6 P52701 P67T 67 P T 0.084 Neutral MSH6 P52701 P67V 67 P V 0.14 Neutral MSH6 P52701 P67W 67 P W 0.39 Neutral MSH6 P52701 P67Y 67 P Y 0.32 Neutral MSH6 P52701 G670A 670 G A 0.044 Neutral MSH6 P52701 G670C 670 G C 0.442 Neutral MSH6 P52701 G670D 670 G D 0.392 Neutral MSH6 P52701 G670E 670 G E 0.474 Neutral MSH6 P52701 G670F 670 G F 0.924 Pathogenic MSH6 P52701 G670H 670 G H 0.898 Pathogenic MSH6 P52701 G670I 670 G I 0.892 Pathogenic MSH6 P52701 G670K 670 G K 0.582 Pathogenic MSH6 P52701 G670L 670 G L 0.556 Pathogenic MSH6 P52701 G670M 670 G M 0.884 Pathogenic MSH6 P52701 G670N 670 G N 0.678 Pathogenic MSH6 P52701 G670P 670 G P 0.858 Pathogenic MSH6 P52701 G670Q 670 G Q 0.458 Neutral MSH6 P52701 G670R 670 G R 0.582 Pathogenic MSH6 P52701 G670S 670 G S 0.07 Neutral MSH6 P52701 G670T 670 G T 0.666 Pathogenic MSH6 P52701 G670V 670 G V 0.554 Pathogenic MSH6 P52701 G670W 670 G W 0.918 Pathogenic MSH6 P52701 G670Y 670 G Y 0.91 Pathogenic MSH6 P52701 L671A 671 L A 0.034 Neutral MSH6 P52701 L671C 671 L C 0.372 Neutral MSH6 P52701 L671D 671 L D 0.532 Pathogenic MSH6 P52701 L671E 671 L E 0.196 Neutral MSH6 P52701 L671F 671 L F 0.376 Neutral MSH6 P52701 L671G 671 L G 0.186 Neutral MSH6 P52701 L671H 671 L H 0.388 Neutral MSH6 P52701 L671I 671 L I 0.042 Neutral MSH6 P52701 L671K 671 L K 0.178 Neutral MSH6 P52701 L671M 671 L M 0.026 Neutral MSH6 P52701 L671N 671 L N 0.6 Pathogenic MSH6 P52701 L671P 671 L P 0.952 Pathogenic MSH6 P52701 L671Q 671 L Q 0.198 Neutral MSH6 P52701 L671R 671 L R 0.864 Pathogenic MSH6 P52701 L671S 671 L S 0.05 Neutral MSH6 P52701 L671T 671 L T 0.42 Neutral MSH6 P52701 L671V 671 L V 0.002 Neutral MSH6 P52701 L671W 671 L W 0.868 Pathogenic MSH6 P52701 L671Y 671 L Y 0.874 Pathogenic MSH6 P52701 T672A 672 T A 0.088 Neutral MSH6 P52701 T672C 672 T C 0.496 Neutral MSH6 P52701 T672D 672 T D 0.21 Neutral MSH6 P52701 T672E 672 T E 0.16 Neutral MSH6 P52701 T672F 672 T F 0.738 Pathogenic MSH6 P52701 T672G 672 T G 0.066 Neutral MSH6 P52701 T672H 672 T H 0.584 Pathogenic MSH6 P52701 T672I 672 T I 0.174 Neutral MSH6 P52701 T672K 672 T K 0.106 Neutral MSH6 P52701 T672L 672 T L 0.122 Neutral MSH6 P52701 T672M 672 T M 0.682 Pathogenic MSH6 P52701 T672N 672 T N 0.032 Neutral MSH6 P52701 T672P 672 T P 0.532 Pathogenic MSH6 P52701 T672Q 672 T Q 0.046 Neutral MSH6 P52701 T672R 672 T R 0.472 Neutral MSH6 P52701 T672S 672 T S 0.032 Neutral MSH6 P52701 T672V 672 T V 0.096 Neutral MSH6 P52701 T672W 672 T W 0.944 Pathogenic MSH6 P52701 T672Y 672 T Y 0.94 Pathogenic MSH6 P52701 P673A 673 P A 0.066 Neutral MSH6 P52701 P673C 673 P C 0.584 Pathogenic MSH6 P52701 P673D 673 P D 0.04 Neutral MSH6 P52701 P673E 673 P E 0.142 Neutral MSH6 P52701 P673F 673 P F 0.974 Pathogenic MSH6 P52701 P673G 673 P G 0.058 Neutral MSH6 P52701 P673H 673 P H 0.628 Pathogenic MSH6 P52701 P673I 673 P I 0.664 Pathogenic MSH6 P52701 P673K 673 P K 0.132 Neutral MSH6 P52701 P673L 673 P L 0.138 Neutral MSH6 P52701 P673M 673 P M 0.726 Pathogenic MSH6 P52701 P673N 673 P N 0.038 Neutral MSH6 P52701 P673Q 673 P Q 0.296 Neutral MSH6 P52701 P673R 673 P R 0.87 Pathogenic MSH6 P52701 P673S 673 P S 0.034 Neutral MSH6 P52701 P673T 673 P T 0.044 Neutral MSH6 P52701 P673V 673 P V 0.284 Neutral MSH6 P52701 P673W 673 P W 0.924 Pathogenic MSH6 P52701 P673Y 673 P Y 0.91 Pathogenic MSH6 P52701 G674A 674 G A 0.088 Neutral MSH6 P52701 G674C 674 G C 0.78 Pathogenic MSH6 P52701 G674D 674 G D 0.464 Neutral MSH6 P52701 G674E 674 G E 0.558 Pathogenic MSH6 P52701 G674F 674 G F 0.97 Pathogenic MSH6 P52701 G674H 674 G H 0.68 Pathogenic MSH6 P52701 G674I 674 G I 0.954 Pathogenic MSH6 P52701 G674K 674 G K 0.602 Pathogenic MSH6 P52701 G674L 674 G L 0.796 Pathogenic MSH6 P52701 G674M 674 G M 0.982 Pathogenic MSH6 P52701 G674N 674 G N 0.486 Neutral MSH6 P52701 G674P 674 G P 0.936 Pathogenic MSH6 P52701 G674Q 674 G Q 0.582 Pathogenic MSH6 P52701 G674R 674 G R 0.612 Pathogenic MSH6 P52701 G674S 674 G S 0.112 Neutral MSH6 P52701 G674T 674 G T 0.738 Pathogenic MSH6 P52701 G674V 674 G V 0.636 Pathogenic MSH6 P52701 G674W 674 G W 0.962 Pathogenic MSH6 P52701 G674Y 674 G Y 0.942 Pathogenic MSH6 P52701 E675A 675 E A 0.108 Neutral MSH6 P52701 E675C 675 E C 0.02 Neutral MSH6 P52701 E675D 675 E D 0.002 Neutral MSH6 P52701 E675F 675 E F 0.442 Neutral MSH6 P52701 E675G 675 E G 0 Neutral MSH6 P52701 E675H 675 E H 0.176 Neutral MSH6 P52701 E675I 675 E I 0.37 Neutral MSH6 P52701 E675K 675 E K 0.012 Neutral MSH6 P52701 E675L 675 E L 0.078 Neutral MSH6 P52701 E675M 675 E M 0.3 Neutral MSH6 P52701 E675N 675 E N 0.072 Neutral MSH6 P52701 E675P 675 E P 0.072 Neutral MSH6 P52701 E675Q 675 E Q 0.052 Neutral MSH6 P52701 E675R 675 E R 0.112 Neutral MSH6 P52701 E675S 675 E S 0.02 Neutral MSH6 P52701 E675T 675 E T 0.3 Neutral MSH6 P52701 E675V 675 E V 0.236 Neutral MSH6 P52701 E675W 675 E W 0.742 Pathogenic MSH6 P52701 E675Y 675 E Y 0.608 Pathogenic MSH6 P52701 K676A 676 K A 0.064 Neutral MSH6 P52701 K676C 676 K C 0.054 Neutral MSH6 P52701 K676D 676 K D 0.004 Neutral MSH6 P52701 K676E 676 K E 0.006 Neutral MSH6 P52701 K676F 676 K F 0.35 Neutral MSH6 P52701 K676G 676 K G 0.052 Neutral MSH6 P52701 K676H 676 K H 0.032 Neutral MSH6 P52701 K676I 676 K I 0.338 Neutral MSH6 P52701 K676L 676 K L 0.364 Neutral MSH6 P52701 K676M 676 K M 0.184 Neutral MSH6 P52701 K676N 676 K N 0.01 Neutral MSH6 P52701 K676P 676 K P 0.026 Neutral MSH6 P52701 K676Q 676 K Q 0.034 Neutral MSH6 P52701 K676R 676 K R 0.008 Neutral MSH6 P52701 K676S 676 K S 0.018 Neutral MSH6 P52701 K676T 676 K T 0.23 Neutral MSH6 P52701 K676V 676 K V 0.286 Neutral MSH6 P52701 K676W 676 K W 0.662 Pathogenic MSH6 P52701 K676Y 676 K Y 0.568 Pathogenic MSH6 P52701 S677A 677 S A 0.012 Neutral MSH6 P52701 S677C 677 S C 0.004 Neutral MSH6 P52701 S677D 677 S D 0.108 Neutral MSH6 P52701 S677E 677 S E 0.222 Neutral MSH6 P52701 S677F 677 S F 0.368 Neutral MSH6 P52701 S677G 677 S G 0.004 Neutral MSH6 P52701 S677H 677 S H 0.288 Neutral MSH6 P52701 S677I 677 S I 0.246 Neutral MSH6 P52701 S677K 677 S K 0.254 Neutral MSH6 P52701 S677L 677 S L 0.076 Neutral MSH6 P52701 S677M 677 S M 0.612 Pathogenic MSH6 P52701 S677N 677 S N 0.058 Neutral MSH6 P52701 S677P 677 S P 0.082 Neutral MSH6 P52701 S677Q 677 S Q 0.316 Neutral MSH6 P52701 S677R 677 S R 0.34 Neutral MSH6 P52701 S677T 677 S T 0.028 Neutral MSH6 P52701 S677V 677 S V 0.394 Neutral MSH6 P52701 S677W 677 S W 0.728 Pathogenic MSH6 P52701 S677Y 677 S Y 0.492 Neutral MSH6 P52701 E678A 678 E A 0.346 Neutral MSH6 P52701 E678C 678 E C 0.346 Neutral MSH6 P52701 E678D 678 E D 0.018 Neutral MSH6 P52701 E678F 678 E F 0.882 Pathogenic MSH6 P52701 E678G 678 E G 0.194 Neutral MSH6 P52701 E678H 678 E H 0.642 Pathogenic MSH6 P52701 E678I 678 E I 0.582 Pathogenic MSH6 P52701 E678K 678 E K 0.042 Neutral MSH6 P52701 E678L 678 E L 0.466 Neutral MSH6 P52701 E678M 678 E M 0.726 Pathogenic MSH6 P52701 E678N 678 E N 0.042 Neutral MSH6 P52701 E678P 678 E P 0.12 Neutral MSH6 P52701 E678Q 678 E Q 0.014 Neutral MSH6 P52701 E678R 678 E R 0.144 Neutral MSH6 P52701 E678S 678 E S 0.05 Neutral MSH6 P52701 E678T 678 E T 0.122 Neutral MSH6 P52701 E678V 678 E V 0.85 Pathogenic MSH6 P52701 E678W 678 E W 0.97 Pathogenic MSH6 P52701 E678Y 678 E Y 0.92 Pathogenic MSH6 P52701 L679A 679 L A 0.134 Neutral MSH6 P52701 L679C 679 L C 0.192 Neutral MSH6 P52701 L679D 679 L D 0.864 Pathogenic MSH6 P52701 L679E 679 L E 0.268 Neutral MSH6 P52701 L679F 679 L F 0.51 Pathogenic MSH6 P52701 L679G 679 L G 0.774 Pathogenic MSH6 P52701 L679H 679 L H 0.804 Pathogenic MSH6 P52701 L679I 679 L I 0.254 Neutral MSH6 P52701 L679K 679 L K 0.72 Pathogenic MSH6 P52701 L679M 679 L M 0.202 Neutral MSH6 P52701 L679N 679 L N 0.26 Neutral MSH6 P52701 L679P 679 L P 0.506 Pathogenic MSH6 P52701 L679Q 679 L Q 0.182 Neutral MSH6 P52701 L679R 679 L R 0.974 Pathogenic MSH6 P52701 L679S 679 L S 0.138 Neutral MSH6 P52701 L679T 679 L T 0.56 Pathogenic MSH6 P52701 L679V 679 L V 0.524 Pathogenic MSH6 P52701 L679W 679 L W 0.832 Pathogenic MSH6 P52701 L679Y 679 L Y 0.662 Pathogenic MSH6 P52701 K68A 68 K A 0.096 Neutral MSH6 P52701 K68C 68 K C 0.028 Neutral MSH6 P52701 K68D 68 K D 0.066 Neutral MSH6 P52701 K68E 68 K E 0.004 Neutral MSH6 P52701 K68F 68 K F 0.212 Neutral MSH6 P52701 K68G 68 K G 0.13 Neutral MSH6 P52701 K68H 68 K H 0.048 Neutral MSH6 P52701 K68I 68 K I 0.222 Neutral MSH6 P52701 K68L 68 K L 0.148 Neutral MSH6 P52701 K68M 68 K M 0.106 Neutral MSH6 P52701 K68N 68 K N 0.05 Neutral MSH6 P52701 K68P 68 K P 0.076 Neutral MSH6 P52701 K68Q 68 K Q 0.09 Neutral MSH6 P52701 K68R 68 K R 0.002 Neutral MSH6 P52701 K68S 68 K S 0.024 Neutral MSH6 P52701 K68T 68 K T 0.09 Neutral MSH6 P52701 K68V 68 K V 0.18 Neutral MSH6 P52701 K68W 68 K W 0.396 Neutral MSH6 P52701 K68Y 68 K Y 0.326 Neutral MSH6 P52701 A680C 680 A C 0.402 Neutral MSH6 P52701 A680D 680 A D 0.956 Pathogenic MSH6 P52701 A680E 680 A E 0.984 Pathogenic MSH6 P52701 A680F 680 A F 0.998 Pathogenic MSH6 P52701 A680G 680 A G 0.114 Neutral MSH6 P52701 A680H 680 A H 0.942 Pathogenic MSH6 P52701 A680I 680 A I 0.96 Pathogenic MSH6 P52701 A680K 680 A K 0.976 Pathogenic MSH6 P52701 A680L 680 A L 0.684 Pathogenic MSH6 P52701 A680M 680 A M 0.66 Pathogenic MSH6 P52701 A680N 680 A N 0.878 Pathogenic MSH6 P52701 A680P 680 A P 0.976 Pathogenic MSH6 P52701 A680Q 680 A Q 0.904 Pathogenic MSH6 P52701 A680R 680 A R 0.982 Pathogenic MSH6 P52701 A680S 680 A S 0.2 Neutral MSH6 P52701 A680T 680 A T 0.22 Neutral MSH6 P52701 A680V 680 A V 0.43 Neutral MSH6 P52701 A680W 680 A W 0.996 Pathogenic MSH6 P52701 A680Y 680 A Y 0.966 Pathogenic MSH6 P52701 L681A 681 L A 0.192 Neutral MSH6 P52701 L681C 681 L C 0.694 Pathogenic MSH6 P52701 L681D 681 L D 0.914 Pathogenic MSH6 P52701 L681E 681 L E 0.894 Pathogenic MSH6 P52701 L681F 681 L F 0.486 Neutral MSH6 P52701 L681G 681 L G 0.812 Pathogenic MSH6 P52701 L681H 681 L H 0.794 Pathogenic MSH6 P52701 L681I 681 L I 0.144 Neutral MSH6 P52701 L681K 681 L K 0.736 Pathogenic MSH6 P52701 L681M 681 L M 0.194 Neutral MSH6 P52701 L681N 681 L N 0.786 Pathogenic MSH6 P52701 L681P 681 L P 0.99 Pathogenic MSH6 P52701 L681Q 681 L Q 0.622 Pathogenic MSH6 P52701 L681R 681 L R 0.998 Pathogenic MSH6 P52701 L681S 681 L S 0.186 Neutral MSH6 P52701 L681T 681 L T 0.336 Neutral MSH6 P52701 L681V 681 L V 0.08 Neutral MSH6 P52701 L681W 681 L W 0.922 Pathogenic MSH6 P52701 L681Y 681 L Y 0.882 Pathogenic MSH6 P52701 S682A 682 S A 0.272 Neutral MSH6 P52701 S682C 682 S C 0.326 Neutral MSH6 P52701 S682D 682 S D 0.866 Pathogenic MSH6 P52701 S682E 682 S E 0.932 Pathogenic MSH6 P52701 S682F 682 S F 0.982 Pathogenic MSH6 P52701 S682G 682 S G 0.19 Neutral MSH6 P52701 S682H 682 S H 0.594 Pathogenic MSH6 P52701 S682I 682 S I 0.884 Pathogenic MSH6 P52701 S682K 682 S K 0.55 Pathogenic MSH6 P52701 S682L 682 S L 0.92 Pathogenic MSH6 P52701 S682M 682 S M 0.998 Pathogenic MSH6 P52701 S682N 682 S N 0.288 Neutral MSH6 P52701 S682P 682 S P 0.954 Pathogenic MSH6 P52701 S682Q 682 S Q 0.578 Pathogenic MSH6 P52701 S682R 682 S R 0.58 Pathogenic MSH6 P52701 S682T 682 S T 0.892 Pathogenic MSH6 P52701 S682V 682 S V 0.97 Pathogenic MSH6 P52701 S682W 682 S W 0.982 Pathogenic MSH6 P52701 S682Y 682 S Y 0.98 Pathogenic MSH6 P52701 A683C 683 A C 0.544 Pathogenic MSH6 P52701 A683D 683 A D 0.922 Pathogenic MSH6 P52701 A683E 683 A E 0.872 Pathogenic MSH6 P52701 A683F 683 A F 0.962 Pathogenic MSH6 P52701 A683G 683 A G 0.738 Pathogenic MSH6 P52701 A683H 683 A H 0.86 Pathogenic MSH6 P52701 A683I 683 A I 0.956 Pathogenic MSH6 P52701 A683K 683 A K 0.932 Pathogenic MSH6 P52701 A683L 683 A L 0.976 Pathogenic MSH6 P52701 A683M 683 A M 0.846 Pathogenic MSH6 P52701 A683N 683 A N 0.856 Pathogenic MSH6 P52701 A683P 683 A P 0.964 Pathogenic MSH6 P52701 A683Q 683 A Q 0.812 Pathogenic MSH6 P52701 A683R 683 A R 0.956 Pathogenic MSH6 P52701 A683S 683 A S 0.25 Neutral MSH6 P52701 A683T 683 A T 0.72 Pathogenic MSH6 P52701 A683V 683 A V 0.904 Pathogenic MSH6 P52701 A683W 683 A W 0.972 Pathogenic MSH6 P52701 A683Y 683 A Y 0.96 Pathogenic MSH6 P52701 L684A 684 L A 0.698 Pathogenic MSH6 P52701 L684C 684 L C 0.816 Pathogenic MSH6 P52701 L684D 684 L D 0.896 Pathogenic MSH6 P52701 L684E 684 L E 0.876 Pathogenic MSH6 P52701 L684F 684 L F 0.444 Neutral MSH6 P52701 L684G 684 L G 0.814 Pathogenic MSH6 P52701 L684H 684 L H 0.906 Pathogenic MSH6 P52701 L684I 684 L I 0.512 Pathogenic MSH6 P52701 L684K 684 L K 0.75 Pathogenic MSH6 P52701 L684M 684 L M 0.176 Neutral MSH6 P52701 L684N 684 L N 0.766 Pathogenic MSH6 P52701 L684P 684 L P 0.992 Pathogenic MSH6 P52701 L684Q 684 L Q 0.734 Pathogenic MSH6 P52701 L684R 684 L R 0.984 Pathogenic MSH6 P52701 L684S 684 L S 0.646 Pathogenic MSH6 P52701 L684T 684 L T 0.284 Neutral MSH6 P52701 L684V 684 L V 0.072 Neutral MSH6 P52701 L684W 684 L W 0.928 Pathogenic MSH6 P52701 L684Y 684 L Y 0.78 Pathogenic MSH6 P52701 G685A 685 G A 0.768 Pathogenic MSH6 P52701 G685C 685 G C 0.948 Pathogenic MSH6 P52701 G685D 685 G D 1 Pathogenic MSH6 P52701 G685E 685 G E 0.988 Pathogenic MSH6 P52701 G685F 685 G F 0.984 Pathogenic MSH6 P52701 G685H 685 G H 0.988 Pathogenic MSH6 P52701 G685I 685 G I 0.974 Pathogenic MSH6 P52701 G685K 685 G K 0.988 Pathogenic MSH6 P52701 G685L 685 G L 0.984 Pathogenic MSH6 P52701 G685M 685 G M 0.994 Pathogenic MSH6 P52701 G685N 685 G N 0.986 Pathogenic MSH6 P52701 G685P 685 G P 0.966 Pathogenic MSH6 P52701 G685Q 685 G Q 0.994 Pathogenic MSH6 P52701 G685R 685 G R 1 Pathogenic MSH6 P52701 G685S 685 G S 0.832 Pathogenic MSH6 P52701 G685T 685 G T 0.846 Pathogenic MSH6 P52701 G685V 685 G V 0.986 Pathogenic MSH6 P52701 G685W 685 G W 0.98 Pathogenic MSH6 P52701 G685Y 685 G Y 0.914 Pathogenic MSH6 P52701 G686A 686 G A 0.322 Neutral MSH6 P52701 G686C 686 G C 0.678 Pathogenic MSH6 P52701 G686D 686 G D 0.974 Pathogenic 4 MSH6 P52701 G686E 686 G E 0.808 Pathogenic MSH6 P52701 G686F 686 G F 0.988 Pathogenic MSH6 P52701 G686H 686 G H 0.992 Pathogenic MSH6 P52701 G686I 686 G I 0.978 Pathogenic MSH6 P52701 G686K 686 G K 0.992 Pathogenic MSH6 P52701 G686L 686 G L 0.812 Pathogenic MSH6 P52701 G686M 686 G M 0.9 Pathogenic MSH6 P52701 G686N 686 G N 0.938 Pathogenic MSH6 P52701 G686P 686 G P 0.982 Pathogenic MSH6 P52701 G686Q 686 G Q 0.592 Pathogenic MSH6 P52701 G686R 686 G R 1 Pathogenic MSH6 P52701 G686S 686 G S 0.316 Neutral MSH6 P52701 G686T 686 G T 0.92 Pathogenic MSH6 P52701 G686V 686 G V 0.99 Pathogenic MSH6 P52701 G686W 686 G W 0.984 Pathogenic MSH6 P52701 G686Y 686 G Y 0.984 Pathogenic MSH6 P52701 C687A 687 C A 0.048 Neutral MSH6 P52701 C687D 687 C D 0.6 Pathogenic MSH6 P52701 C687E 687 C E 0.592 Pathogenic MSH6 P52701 C687F 687 C F 0.946 Pathogenic MSH6 P52701 C687G 687 C G 0.512 Pathogenic MSH6 P52701 C687H 687 C H 0.726 Pathogenic MSH6 P52701 C687I 687 C I 0.134 Neutral MSH6 P52701 C687K 687 C K 0.652 Pathogenic MSH6 P52701 C687L 687 C L 0.088 Neutral MSH6 P52701 C687M 687 C M 0.104 Neutral MSH6 P52701 C687N 687 C N 0.37 Neutral MSH6 P52701 C687P 687 C P 0.87 Pathogenic MSH6 P52701 C687Q 687 C Q 0.498 Neutral MSH6 P52701 C687R 687 C R 0.916 Pathogenic MSH6 P52701 C687S 687 C S 0.028 Neutral MSH6 P52701 C687T 687 C T 0.016 Neutral MSH6 P52701 C687V 687 C V 0.064 Neutral MSH6 P52701 C687W 687 C W 0.938 Pathogenic MSH6 P52701 C687Y 687 C Y 0.94 Pathogenic MSH6 P52701 V688A 688 V A 0.318 Neutral MSH6 P52701 V688C 688 V C 0.654 Pathogenic MSH6 P52701 V688D 688 V D 0.844 Pathogenic MSH6 P52701 V688E 688 V E 0.952 Pathogenic MSH6 P52701 V688F 688 V F 0.51 Pathogenic MSH6 P52701 V688G 688 V G 0.906 Pathogenic MSH6 P52701 V688H 688 V H 0.338 Neutral MSH6 P52701 V688I 688 V I 0.144 Neutral MSH6 P52701 V688K 688 V K 0.928 Pathogenic MSH6 P52701 V688L 688 V L 0.188 Neutral MSH6 P52701 V688M 688 V M 0.282 Neutral MSH6 P52701 V688N 688 V N 0.916 Pathogenic MSH6 P52701 V688P 688 V P 0.934 Pathogenic MSH6 P52701 V688Q 688 V Q 0.966 Pathogenic MSH6 P52701 V688R 688 V R 0.946 Pathogenic MSH6 P52701 V688S 688 V S 0.366 Neutral MSH6 P52701 V688T 688 V T 0.106 Neutral MSH6 P52701 V688W 688 V W 0.886 Pathogenic MSH6 P52701 V688Y 688 V Y 0.902 Pathogenic MSH6 P52701 F689A 689 F A 0.246 Neutral MSH6 P52701 F689C 689 F C 0.044 Neutral MSH6 P52701 F689D 689 F D 0.568 Pathogenic MSH6 P52701 F689E 689 F E 0.656 Pathogenic MSH6 P52701 F689G 689 F G 0.344 Neutral MSH6 P52701 F689H 689 F H 0.02 Neutral MSH6 P52701 F689I 689 F I 0.448 Neutral MSH6 P52701 F689K 689 F K 0.612 Pathogenic MSH6 P52701 F689L 689 F L 0.374 Neutral MSH6 P52701 F689M 689 F M 0.176 Neutral MSH6 P52701 F689N 689 F N 0.286 Neutral MSH6 P52701 F689P 689 F P 0.762 Pathogenic MSH6 P52701 F689Q 689 F Q 0.088 Neutral MSH6 P52701 F689R 689 F R 0.636 Pathogenic MSH6 P52701 F689S 689 F S 0.072 Neutral MSH6 P52701 F689T 689 F T 0.448 Neutral MSH6 P52701 F689V 689 F V 0.47 Neutral MSH6 P52701 F689W 689 F W 0.576 Pathogenic MSH6 P52701 F689Y 689 F Y 0.034 Neutral MSH6 P52701 A69C 69 A C 0.182 Neutral MSH6 P52701 A69D 69 A D 0.266 Neutral MSH6 P52701 A69E 69 A E 0.302 Neutral MSH6 P52701 A69F 69 A F 0.468 Neutral MSH6 P52701 A69G 69 A G 0.074 Neutral MSH6 P52701 A69H 69 A H 0.304 Neutral MSH6 P52701 A69I 69 A I 0.406 Neutral MSH6 P52701 A69K 69 A K 0.29 Neutral MSH6 P52701 A69L 69 A L 0.354 Neutral MSH6 P52701 A69M 69 A M 0.29 Neutral MSH6 P52701 A69N 69 A N 0.274 Neutral MSH6 P52701 A69P 69 A P 0.3 Neutral MSH6 P52701 A69Q 69 A Q 0.302 Neutral MSH6 P52701 A69R 69 A R 0.36 Neutral MSH6 P52701 A69S 69 A S 0.008 Neutral MSH6 P52701 A69T 69 A T 0.014 Neutral MSH6 P52701 A69V 69 A V 0.202 Neutral MSH6 P52701 A69W 69 A W 0.504 Pathogenic MSH6 P52701 A69Y 69 A Y 0.5 Pathogenic MSH6 P52701 Y690A 690 Y A 0.434 Neutral MSH6 P52701 Y690C 690 Y C 0.318 Neutral MSH6 P52701 Y690D 690 Y D 0.834 Pathogenic MSH6 P52701 Y690E 690 Y E 0.734 Pathogenic MSH6 P52701 Y690F 690 Y F 0.2 Neutral MSH6 P52701 Y690G 690 Y G 0.48 Neutral MSH6 P52701 Y690H 690 Y H 0.168 Neutral MSH6 P52701 Y690I 690 Y I 0.794 Pathogenic MSH6 P52701 Y690K 690 Y K 0.804 Pathogenic MSH6 P52701 Y690L 690 Y L 0.21 Neutral MSH6 P52701 Y690M 690 Y M 0.67 Pathogenic MSH6 P52701 Y690N 690 Y N 0.308 Neutral MSH6 P52701 Y690P 690 Y P 0.774 Pathogenic MSH6 P52701 Y690Q 690 Y Q 0.268 Neutral MSH6 P52701 Y690R 690 Y R 0.476 Neutral MSH6 P52701 Y690S 690 Y S 0.48 Neutral MSH6 P52701 Y690T 690 Y T 0.366 Neutral MSH6 P52701 Y690V 690 Y V 0.624 Pathogenic MSH6 P52701 Y690W 690 Y W 0.904 Pathogenic MSH6 P52701 L691A 691 L A 0.712 Pathogenic MSH6 P52701 L691C 691 L C 0.822 Pathogenic MSH6 P52701 L691D 691 L D 0.91 Pathogenic MSH6 P52701 L691E 691 L E 0.894 Pathogenic MSH6 P52701 L691F 691 L F 0.878 Pathogenic MSH6 P52701 L691G 691 L G 0.862 Pathogenic MSH6 P52701 L691H 691 L H 0.908 Pathogenic MSH6 P52701 L691I 691 L I 0.452 Neutral MSH6 P52701 L691K 691 L K 0.718 Pathogenic MSH6 P52701 L691M 691 L M 0.49 Neutral MSH6 P52701 L691N 691 L N 0.82 Pathogenic MSH6 P52701 L691P 691 L P 0.994 Pathogenic MSH6 P52701 L691Q 691 L Q 0.774 Pathogenic MSH6 P52701 L691R 691 L R 0.984 Pathogenic MSH6 P52701 L691S 691 L S 0.496 Neutral MSH6 P52701 L691T 691 L T 0.464 Neutral MSH6 P52701 L691V 691 L V 0.43 Neutral MSH6 P52701 L691W 691 L W 0.882 Pathogenic MSH6 P52701 L691Y 691 L Y 0.89 Pathogenic MSH6 P52701 K692A 692 K A 0.124 Neutral MSH6 P52701 K692C 692 K C 0.42 Neutral MSH6 P52701 K692D 692 K D 0.588 Pathogenic MSH6 P52701 K692E 692 K E 0.132 Neutral MSH6 P52701 K692F 692 K F 0.81 Pathogenic MSH6 P52701 K692G 692 K G 0.224 Neutral MSH6 P52701 K692H 692 K H 0.08 Neutral MSH6 P52701 K692I 692 K I 0.972 Pathogenic MSH6 P52701 K692L 692 K L 0.956 Pathogenic MSH6 P52701 K692M 692 K M 0.454 Neutral MSH6 P52701 K692N 692 K N 0.252 Neutral MSH6 P52701 K692P 692 K P 0.874 Pathogenic MSH6 P52701 K692Q 692 K Q 0.084 Neutral MSH6 P52701 K692R 692 K R 0.096 Neutral MSH6 P52701 K692S 692 K S 0.128 Neutral MSH6 P52701 K692T 692 K T 0.11 Neutral MSH6 P52701 K692V 692 K V 0.51 Pathogenic MSH6 P52701 K692W 692 K W 0.978 Pathogenic MSH6 P52701 K692Y 692 K Y 0.962 Pathogenic MSH6 P52701 K693A 693 K A 0.222 Neutral MSH6 P52701 K693C 693 K C 0.188 Neutral MSH6 P52701 K693D 693 K D 0.012 Neutral MSH6 P52701 K693E 693 K E 0.014 Neutral MSH6 P52701 K693F 693 K F 0.086 Neutral MSH6 P52701 K693G 693 K G 0.404 Neutral MSH6 P52701 K693H 693 K H 0.2 Neutral MSH6 P52701 K693I 693 K I 0.456 Neutral MSH6 P52701 K693L 693 K L 0.086 Neutral MSH6 P52701 K693M 693 K M 0.036 Neutral MSH6 P52701 K693N 693 K N 0.176 Neutral MSH6 P52701 K693P 693 K P 0.786 Pathogenic MSH6 P52701 K693Q 693 K Q 0.022 Neutral MSH6 P52701 K693R 693 K R 0.014 Neutral MSH6 P52701 K693S 693 K S 0.03 Neutral MSH6 P52701 K693T 693 K T 0.026 Neutral MSH6 P52701 K693V 693 K V 0.098 Neutral MSH6 P52701 K693W 693 K W 0.942 Pathogenic MSH6 P52701 K693Y 693 K Y 0.274 Neutral MSH6 P52701 C694A 694 C A 0.056 Neutral MSH6 P52701 C694D 694 C D 0.588 Pathogenic MSH6 P52701 C694E 694 C E 0.552 Pathogenic MSH6 P52701 C694F 694 C F 0.642 Pathogenic MSH6 P52701 C694G 694 C G 0.32 Neutral MSH6 P52701 C694H 694 C H 0.696 Pathogenic MSH6 P52701 C694I 694 C I 0.202 Neutral MSH6 P52701 C694K 694 C K 0.612 Pathogenic MSH6 P52701 C694L 694 C L 0.136 Neutral MSH6 P52701 C694M 694 C M 0.538 Pathogenic MSH6 P52701 C694N 694 C N 0.132 Neutral MSH6 P52701 C694P 694 C P 0.83 Pathogenic MSH6 P52701 C694Q 694 C Q 0.468 Neutral MSH6 P52701 C694R 694 C R 0.906 Pathogenic MSH6 P52701 C694S 694 C S 0.032 Neutral MSH6 P52701 C694T 694 C T 0.346 Neutral MSH6 P52701 C694V 694 C V 0.334 Neutral MSH6 P52701 C694W 694 C W 0.92 Pathogenic MSH6 P52701 C694Y 694 C Y 0.586 Pathogenic MSH6 P52701 L695A 695 L A 0.322 Neutral MSH6 P52701 L695C 695 L C 0.032 Neutral MSH6 P52701 L695D 695 L D 0.66 Pathogenic MSH6 P52701 L695E 695 L E 0.412 Neutral MSH6 P52701 L695F 695 L F 0.274 Neutral MSH6 P52701 L695G 695 L G 0.57 Pathogenic MSH6 P52701 L695H 695 L H 0.176 Neutral MSH6 P52701 L695I 695 L I 0.048 Neutral MSH6 P52701 L695K 695 L K 0.05 Neutral MSH6 P52701 L695M 695 L M 0.028 Neutral MSH6 P52701 L695N 695 L N 0.214 Neutral MSH6 P52701 L695P 695 L P 0.882 Pathogenic MSH6 P52701 L695Q 695 L Q 0.06 Neutral MSH6 P52701 L695R 695 L R 0.856 Pathogenic MSH6 P52701 L695S 695 L S 0.35 Neutral MSH6 P52701 L695T 695 L T 0.334 Neutral MSH6 P52701 L695V 695 L V 0.366 Neutral MSH6 P52701 L695W 695 L W 0.81 Pathogenic MSH6 P52701 L695Y 695 L Y 0.644 Pathogenic MSH6 P52701 I696A 696 I A 0.466 Neutral MSH6 P52701 I696C 696 I C 0.606 Pathogenic MSH6 P52701 I696D 696 I D 0.748 Pathogenic MSH6 P52701 I696E 696 I E 0.758 Pathogenic MSH6 P52701 I696F 696 I F 0.96 Pathogenic MSH6 P52701 I696G 696 I G 0.798 Pathogenic MSH6 P52701 I696H 696 I H 0.848 Pathogenic MSH6 P52701 I696K 696 I K 0.846 Pathogenic MSH6 P52701 I696L 696 I L 0.152 Neutral MSH6 P52701 I696M 696 I M 0.182 Neutral MSH6 P52701 I696N 696 I N 0.774 Pathogenic MSH6 P52701 I696P 696 I P 0.934 Pathogenic MSH6 P52701 I696Q 696 I Q 0.788 Pathogenic MSH6 P52701 I696R 696 I R 0.874 Pathogenic MSH6 P52701 I696S 696 I S 0.616 Pathogenic MSH6 P52701 I696T 696 I T 0.11 Neutral MSH6 P52701 I696V 696 I V 0.112 Neutral MSH6 P52701 I696W 696 I W 0.986 Pathogenic MSH6 P52701 I696Y 696 I Y 0.976 Pathogenic MSH6 P52701 D697A 697 D A 0.264 Neutral MSH6 P52701 D697C 697 D C 0.91 Pathogenic MSH6 P52701 D697E 697 D E 0.212 Neutral MSH6 P52701 D697F 697 D F 0.986 Pathogenic MSH6 P52701 D697G 697 D G 0.158 Neutral MSH6 P52701 D697H 697 D H 0.642 Pathogenic MSH6 P52701 D697I 697 D I 0.792 Pathogenic MSH6 P52701 D697K 697 D K 0.982 Pathogenic MSH6 P52701 D697L 697 D L 0.744 Pathogenic MSH6 P52701 D697M 697 D M 0.962 Pathogenic MSH6 P52701 D697N 697 D N 0.842 Pathogenic MSH6 P52701 D697P 697 D P 0.906 Pathogenic MSH6 P52701 D697Q 697 D Q 0.738 Pathogenic MSH6 P52701 D697R 697 D R 0.95 Pathogenic MSH6 P52701 D697S 697 D S 0.7 Pathogenic MSH6 P52701 D697T 697 D T 0.842 Pathogenic MSH6 P52701 D697V 697 D V 0.992 Pathogenic MSH6 P52701 D697W 697 D W 0.984 Pathogenic MSH6 P52701 D697Y 697 D Y 0.978 Pathogenic MSH6 P52701 Q698A 698 Q A 0.434 Neutral MSH6 P52701 Q698C 698 Q C 0.43 Neutral MSH6 P52701 Q698D 698 Q D 0.136 Neutral MSH6 P52701 Q698E 698 Q E 0.04 Neutral MSH6 P52701 Q698F 698 Q F 0.348 Neutral MSH6 P52701 Q698G 698 Q G 0.126 Neutral MSH6 P52701 Q698H 698 Q H 0.082 Neutral MSH6 P52701 Q698I 698 Q I 0.432 Neutral MSH6 P52701 Q698K 698 Q K 0.062 Neutral MSH6 P52701 Q698L 698 Q L 0.72 Pathogenic MSH6 P52701 Q698M 698 Q M 0.728 Pathogenic MSH6 P52701 Q698N 698 Q N 0.404 Neutral MSH6 P52701 Q698P 698 Q P 0.338 Neutral MSH6 P52701 Q698R 698 Q R 0.082 Neutral MSH6 P52701 Q698S 698 Q S 0.652 Pathogenic MSH6 P52701 Q698T 698 Q T 0.14 Neutral MSH6 P52701 Q698V 698 Q V 0.1 Neutral MSH6 P52701 Q698W 698 Q W 0.9 Pathogenic MSH6 P52701 Q698Y 698 Q Y 0.466 Neutral MSH6 P52701 E699A 699 E A 0.58 Pathogenic MSH6 P52701 E699C 699 E C 0.494 Neutral MSH6 P52701 E699D 699 E D 0.014 Neutral MSH6 P52701 E699F 699 E F 0.878 Pathogenic MSH6 P52701 E699G 699 E G 0.214 Neutral MSH6 P52701 E699H 699 E H 0.61 Pathogenic MSH6 P52701 E699I 699 E I 0.938 Pathogenic MSH6 P52701 E699K 699 E K 0.03 Neutral MSH6 P52701 E699L 699 E L 0.778 Pathogenic MSH6 P52701 E699M 699 E M 0.712 Pathogenic MSH6 P52701 E699N 699 E N 0.018 Neutral MSH6 P52701 E699P 699 E P 0.114 Neutral MSH6 P52701 E699Q 699 E Q 0.012 Neutral MSH6 P52701 E699R 699 E R 0.184 Neutral MSH6 P52701 E699S 699 E S 0.044 Neutral MSH6 P52701 E699T 699 E T 0.042 Neutral MSH6 P52701 E699V 699 E V 0.85 Pathogenic MSH6 P52701 E699W 699 E W 0.966 Pathogenic MSH6 P52701 E699Y 699 E Y 0.886 Pathogenic MSH6 P52701 L7A 7 L A 0.088 Neutral MSH6 P52701 L7C 7 L C 0.094 Neutral MSH6 P52701 L7D 7 L D 0.158 Neutral MSH6 P52701 L7E 7 L E 0.144 Neutral MSH6 P52701 L7F 7 L F 0.204 Neutral MSH6 P52701 L7G 7 L G 0.186 Neutral MSH6 P52701 L7H 7 L H 0.084 Neutral MSH6 P52701 L7I 7 L I 0.004 Neutral MSH6 P52701 L7K 7 L K 0.022 Neutral MSH6 P52701 L7M 7 L M 0.132 Neutral MSH6 P52701 L7N 7 L N 0.148 Neutral MSH6 P52701 L7P 7 L P 0.216 Neutral MSH6 P52701 L7Q 7 L Q 0.064 Neutral MSH6 P52701 L7R 7 L R 0.218 Neutral MSH6 P52701 L7S 7 L S 0.134 Neutral MSH6 P52701 L7T 7 L T 0.112 Neutral MSH6 P52701 L7V 7 L V 0.114 Neutral MSH6 P52701 L7W 7 L W 0.334 Neutral MSH6 P52701 L7Y 7 L Y 0.284 Neutral MSH6 P52701 K70A 70 K A 0.054 Neutral MSH6 P52701 K70C 70 K C 0.028 Neutral MSH6 P52701 K70D 70 K D 0.066 Neutral MSH6 P52701 K70E 70 K E 0.052 Neutral MSH6 P52701 K70F 70 K F 0.23 Neutral MSH6 P52701 K70G 70 K G 0.132 Neutral MSH6 P52701 K70H 70 K H 0.048 Neutral MSH6 P52701 K70I 70 K I 0.222 Neutral MSH6 P52701 K70L 70 K L 0.148 Neutral MSH6 P52701 K70M 70 K M 0.106 Neutral MSH6 P52701 K70N 70 K N 0.046 Neutral MSH6 P52701 K70P 70 K P 0.076 Neutral MSH6 P52701 K70Q 70 K Q 0.01 Neutral MSH6 P52701 K70R 70 K R 0.002 Neutral MSH6 P52701 K70S 70 K S 0.176 Neutral MSH6 P52701 K70T 70 K T 0.09 Neutral MSH6 P52701 K70V 70 K V 0.18 Neutral MSH6 P52701 K70W 70 K W 0.396 Neutral MSH6 P52701 K70Y 70 K Y 0.326 Neutral MSH6 P52701 L700A 700 L A 0.638 Pathogenic MSH6 P52701 L700C 700 L C 0.762 Pathogenic MSH6 P52701 L700D 700 L D 0.886 Pathogenic MSH6 P52701 L700E 700 L E 0.866 Pathogenic MSH6 P52701 L700F 700 L F 0.98 Pathogenic MSH6 P52701 L700G 700 L G 0.8 Pathogenic MSH6 P52701 L700H 700 L H 0.876 Pathogenic MSH6 P52701 L700I 700 L I 0.194 Neutral MSH6 P52701 L700K 700 L K 0.754 Pathogenic MSH6 P52701 L700M 700 L M 0.17 Neutral MSH6 P52701 L700N 700 L N 0.75 Pathogenic MSH6 P52701 L700P 700 L P 0.992 Pathogenic MSH6 P52701 L700Q 700 L Q 0.688 Pathogenic MSH6 P52701 L700R 700 L R 0.984 Pathogenic MSH6 P52701 L700S 700 L S 0.634 Pathogenic MSH6 P52701 L700T 700 L T 0.328 Neutral MSH6 P52701 L700V 700 L V 0.068 Neutral MSH6 P52701 L700W 700 L W 0.942 Pathogenic MSH6 P52701 L700Y 700 L Y 0.904 Pathogenic MSH6 P52701 L701A 701 L A 0.632 Pathogenic MSH6 P52701 L701C 701 L C 0.164 Neutral MSH6 P52701 L701D 701 L D 0.88 Pathogenic MSH6 P52701 L701E 701 L E 0.868 Pathogenic MSH6 P52701 L701F 701 L F 0.51 Pathogenic MSH6 P52701 L701G 701 L G 0.79 Pathogenic MSH6 P52701 L701H 701 L H 0.882 Pathogenic MSH6 P52701 L701I 701 L I 0.192 Neutral MSH6 P52701 L701K 701 L K 0.74 Pathogenic MSH6 P52701 L701M 701 L M 0.202 Neutral MSH6 P52701 L701N 701 L N 0.746 Pathogenic MSH6 P52701 L701P 701 L P 0.982 Pathogenic MSH6 P52701 L701Q 701 L Q 0.682 Pathogenic MSH6 P52701 L701R 701 L R 0.988 Pathogenic MSH6 P52701 L701S 701 L S 0.598 Pathogenic MSH6 P52701 L701T 701 L T 0.57 Pathogenic MSH6 P52701 L701V 701 L V 0.076 Neutral MSH6 P52701 L701W 701 L W 0.94 Pathogenic MSH6 P52701 L701Y 701 L Y 0.9 Pathogenic MSH6 P52701 S702A 702 S A 0.144 Neutral MSH6 P52701 S702C 702 S C 0.716 Pathogenic MSH6 P52701 S702D 702 S D 0.748 Pathogenic MSH6 P52701 S702E 702 S E 0.58 Pathogenic MSH6 P52701 S702F 702 S F 0.968 Pathogenic MSH6 P52701 S702G 702 S G 0.142 Neutral MSH6 P52701 S702H 702 S H 0.906 Pathogenic MSH6 P52701 S702I 702 S I 0.81 Pathogenic MSH6 P52701 S702K 702 S K 0.522 Pathogenic MSH6 P52701 S702L 702 S L 0.674 Pathogenic MSH6 P52701 S702M 702 S M 0.986 Pathogenic MSH6 P52701 S702N 702 S N 0.346 Neutral MSH6 P52701 S702P 702 S P 0.312 Neutral MSH6 P52701 S702Q 702 S Q 0.512 Pathogenic MSH6 P52701 S702R 702 S R 0.53 Pathogenic MSH6 P52701 S702T 702 S T 0.252 Neutral MSH6 P52701 S702V 702 S V 0.854 Pathogenic MSH6 P52701 S702W 702 S W 0.932 Pathogenic MSH6 P52701 S702Y 702 S Y 0.93 Pathogenic MSH6 P52701 M703A 703 M A 0.166 Neutral MSH6 P52701 M703C 703 M C 0.018 Neutral MSH6 P52701 M703D 703 M D 0.674 Pathogenic MSH6 P52701 M703E 703 M E 0.434 Neutral MSH6 P52701 M703F 703 M F 0.07 Neutral MSH6 P52701 M703G 703 M G 0.356 Neutral MSH6 P52701 M703H 703 M H 0.508 Pathogenic MSH6 P52701 M703I 703 M I 0.056 Neutral MSH6 P52701 M703K 703 M K 0.684 Pathogenic MSH6 P52701 M703L 703 M L 0.044 Neutral MSH6 P52701 M703N 703 M N 0.692 Pathogenic MSH6 P52701 M703P 703 M P 0.874 Pathogenic MSH6 P52701 M703Q 703 M Q 0.018 Neutral MSH6 P52701 M703R 703 M R 0.226 Neutral MSH6 P52701 M703S 703 M S 0.504 Pathogenic MSH6 P52701 M703T 703 M T 0.154 Neutral MSH6 P52701 M703V 703 M V 0.404 Neutral MSH6 P52701 M703W 703 M W 0.95 Pathogenic MSH6 P52701 M703Y 703 M Y 0.884 Pathogenic MSH6 P52701 A704C 704 A C 0.356 Neutral MSH6 P52701 A704D 704 A D 0.822 Pathogenic MSH6 P52701 A704E 704 A E 0.858 Pathogenic MSH6 P52701 A704F 704 A F 0.924 Pathogenic MSH6 P52701 A704G 704 A G 0.156 Neutral MSH6 P52701 A704H 704 A H 0.628 Pathogenic MSH6 P52701 A704I 704 A I 0.88 Pathogenic MSH6 P52701 A704K 704 A K 0.652 Pathogenic MSH6 P52701 A704L 704 A L 0.92 Pathogenic MSH6 P52701 A704M 704 A M 0.762 Pathogenic MSH6 P52701 A704N 704 A N 0.662 Pathogenic MSH6 P52701 A704P 704 A P 0.9 Pathogenic MSH6 P52701 A704Q 704 A Q 0.578 Pathogenic MSH6 P52701 A704R 704 A R 0.612 Pathogenic MSH6 P52701 A704S 704 A S 0.132 Neutral MSH6 P52701 A704T 704 A T 0.734 Pathogenic MSH6 P52701 A704V 704 A V 0.778 Pathogenic MSH6 P52701 A704W 704 A W 0.924 Pathogenic MSH6 P52701 A704Y 704 A Y 0.89 Pathogenic MSH6 P52701 N705A 705 N A 0.53 Pathogenic MSH6 P52701 N705C 705 N C 0.064 Neutral MSH6 P52701 N705D 705 N D 0.038 Neutral MSH6 P52701 N705E 705 N E 0.064 Neutral MSH6 P52701 N705F 705 N F 0.908 Pathogenic MSH6 P52701 N705G 705 N G 0.612 Pathogenic MSH6 P52701 N705H 705 N H 0.724 Pathogenic MSH6 P52701 N705I 705 N I 0.55 Pathogenic MSH6 P52701 N705K 705 N K 0.08 Neutral MSH6 P52701 N705L 705 N L 0.192 Neutral MSH6 P52701 N705M 705 N M 0.872 Pathogenic MSH6 P52701 N705P 705 N P 0.76 Pathogenic MSH6 P52701 N705Q 705 N Q 0.036 Neutral MSH6 P52701 N705R 705 N R 0.462 Neutral MSH6 P52701 N705S 705 N S 0.056 Neutral MSH6 P52701 N705T 705 N T 0.102 Neutral MSH6 P52701 N705V 705 N V 0.79 Pathogenic MSH6 P52701 N705W 705 N W 0.946 Pathogenic MSH6 P52701 N705Y 705 N Y 0.938 Pathogenic MSH6 P52701 F706A 706 F A 0.5 Pathogenic MSH6 P52701 F706C 706 F C 0.73 Pathogenic MSH6 P52701 F706D 706 F D 0.814 Pathogenic MSH6 P52701 F706E 706 F E 0.858 Pathogenic MSH6 P52701 F706G 706 F G 0.512 Pathogenic MSH6 P52701 F706H 706 F H 0.76 Pathogenic MSH6 P52701 F706I 706 F I 0.244 Neutral MSH6 P52701 F706K 706 F K 0.836 Pathogenic MSH6 P52701 F706L 706 F L 0.696 Pathogenic MSH6 P52701 F706M 706 F M 0.778 Pathogenic MSH6 P52701 F706N 706 F N 0.762 Pathogenic MSH6 P52701 F706P 706 F P 0.952 Pathogenic MSH6 P52701 F706Q 706 F Q 0.774 Pathogenic MSH6 P52701 F706R 706 F R 0.906 Pathogenic MSH6 P52701 F706S 706 F S 0.884 Pathogenic 4 MSH6 P52701 F706T 706 F T 0.592 Pathogenic MSH6 P52701 F706V 706 F V 0.194 Neutral MSH6 P52701 F706W 706 F W 0.85 Pathogenic MSH6 P52701 F706Y 706 F Y 0.262 Neutral MSH6 P52701 E707A 707 E A 0.222 Neutral MSH6 P52701 E707C 707 E C 0.494 Neutral MSH6 P52701 E707D 707 E D 0.082 Neutral MSH6 P52701 E707F 707 E F 0.876 Pathogenic MSH6 P52701 E707G 707 E G 0.214 Neutral MSH6 P52701 E707H 707 E H 0.036 Neutral MSH6 P52701 E707I 707 E I 0.554 Pathogenic MSH6 P52701 E707K 707 E K 0.034 Neutral MSH6 P52701 E707L 707 E L 0.776 Pathogenic MSH6 P52701 E707M 707 E M 0.304 Neutral MSH6 P52701 E707N 707 E N 0.014 Neutral MSH6 P52701 E707P 707 E P 0.888 Pathogenic MSH6 P52701 E707Q 707 E Q 0.01 Neutral MSH6 P52701 E707R 707 E R 0.132 Neutral MSH6 P52701 E707S 707 E S 0.042 Neutral MSH6 P52701 E707T 707 E T 0.038 Neutral MSH6 P52701 E707V 707 E V 0.406 Neutral MSH6 P52701 E707W 707 E W 0.964 Pathogenic MSH6 P52701 E707Y 707 E Y 0.618 Pathogenic MSH6 P52701 E708A 708 E A 0.172 Neutral MSH6 P52701 E708C 708 E C 0.322 Neutral MSH6 P52701 E708D 708 E D 0.332 Neutral MSH6 P52701 E708F 708 E F 0.406 Neutral MSH6 P52701 E708G 708 E G 0.226 Neutral MSH6 P52701 E708H 708 E H 0.464 Neutral MSH6 P52701 E708I 708 E I 0.172 Neutral MSH6 P52701 E708K 708 E K 0.04 Neutral MSH6 P52701 E708L 708 E L 0.098 Neutral MSH6 P52701 E708M 708 E M 0.06 Neutral MSH6 P52701 E708N 708 E N 0.174 Neutral MSH6 P52701 E708P 708 E P 0.2 Neutral MSH6 P52701 E708Q 708 E Q 0.058 Neutral MSH6 P52701 E708R 708 E R 0.066 Neutral MSH6 P52701 E708S 708 E S 0.066 Neutral MSH6 P52701 E708T 708 E T 0.058 Neutral MSH6 P52701 E708V 708 E V 0.09 Neutral MSH6 P52701 E708W 708 E W 0.546 Pathogenic MSH6 P52701 E708Y 708 E Y 0.778 Pathogenic MSH6 P52701 Y709A 709 Y A 0.426 Neutral MSH6 P52701 Y709C 709 Y C 0.662 Pathogenic MSH6 P52701 Y709D 709 Y D 0.812 Pathogenic MSH6 P52701 Y709E 709 Y E 0.716 Pathogenic MSH6 P52701 Y709F 709 Y F 0.188 Neutral MSH6 P52701 Y709G 709 Y G 0.476 Neutral MSH6 P52701 Y709H 709 Y H 0.59 Pathogenic MSH6 P52701 Y709I 709 Y I 0.258 Neutral MSH6 P52701 Y709K 709 Y K 0.822 Pathogenic MSH6 P52701 Y709L 709 Y L 0.196 Neutral MSH6 P52701 Y709M 709 Y M 0.678 Pathogenic MSH6 P52701 Y709N 709 Y N 0.708 Pathogenic MSH6 P52701 Y709P 709 Y P 0.796 Pathogenic MSH6 P52701 Y709Q 709 Y Q 0.618 Pathogenic MSH6 P52701 Y709R 709 Y R 0.734 Pathogenic MSH6 P52701 Y709S 709 Y S 0.476 Neutral MSH6 P52701 Y709T 709 Y T 0.658 Pathogenic MSH6 P52701 Y709V 709 Y V 0.716 Pathogenic MSH6 P52701 Y709W 709 Y W 0.91 Pathogenic MSH6 P52701 N71A 71 N A 0.07 Neutral MSH6 P52701 N71C 71 N C 0.158 Neutral MSH6 P52701 N71D 71 N D 0.068 Neutral MSH6 P52701 N71E 71 N E 0.086 Neutral MSH6 P52701 N71F 71 N F 0.34 Neutral MSH6 P52701 N71G 71 N G 0.1 Neutral MSH6 P52701 N71H 71 N H 0.23 Neutral MSH6 P52701 N71I 71 N I 0.266 Neutral MSH6 P52701 N71K 71 N K 0.148 Neutral MSH6 P52701 N71L 71 N L 0.272 Neutral MSH6 P52701 N71M 71 N M 0.22 Neutral MSH6 P52701 N71P 71 N P 0.228 Neutral MSH6 P52701 N71Q 71 N Q 0.114 Neutral MSH6 P52701 N71R 71 N R 0.158 Neutral MSH6 P52701 N71S 71 N S 0 Neutral MSH6 P52701 N71T 71 N T 0.08 Neutral MSH6 P52701 N71V 71 N V 0.262 Neutral MSH6 P52701 N71W 71 N W 0.446 Neutral MSH6 P52701 N71Y 71 N Y 0.402 Neutral MSH6 P52701 I710A 710 I A 0.09 Neutral MSH6 P52701 I710C 710 I C 0.1 Neutral MSH6 P52701 I710D 710 I D 0.036 Neutral MSH6 P52701 I710E 710 I E 0.04 Neutral MSH6 P52701 I710F 710 I F 0.1 Neutral MSH6 P52701 I710G 710 I G 0.29 Neutral MSH6 P52701 I710H 710 I H 0.128 Neutral MSH6 P52701 I710K 710 I K 0.052 Neutral MSH6 P52701 I710L 710 I L 0.182 Neutral MSH6 P52701 I710M 710 I M 0.168 Neutral MSH6 P52701 I710N 710 I N 0.106 Neutral MSH6 P52701 I710P 710 I P 0.26 Neutral MSH6 P52701 I710Q 710 I Q 0.108 Neutral MSH6 P52701 I710R 710 I R 0.364 Neutral MSH6 P52701 I710S 710 I S 0.078 Neutral MSH6 P52701 I710T 710 I T 0.008 Neutral MSH6 P52701 I710V 710 I V 0 Neutral MSH6 P52701 I710W 710 I W 0.584 Pathogenic MSH6 P52701 I710Y 710 I Y 0.498 Neutral MSH6 P52701 P711A 711 P A 0.448 Neutral MSH6 P52701 P711C 711 P C 0.902 Pathogenic MSH6 P52701 P711D 711 P D 0.846 Pathogenic MSH6 P52701 P711E 711 P E 0.596 Pathogenic MSH6 P52701 P711F 711 P F 0.996 Pathogenic MSH6 P52701 P711G 711 P G 0.598 Pathogenic MSH6 P52701 P711H 711 P H 0.978 Pathogenic MSH6 P52701 P711I 711 P I 0.934 Pathogenic MSH6 P52701 P711K 711 P K 0.952 Pathogenic MSH6 P52701 P711L 711 P L 0.996 Pathogenic MSH6 P52701 P711M 711 P M 0.954 Pathogenic MSH6 P52701 P711N 711 P N 0.39 Neutral MSH6 P52701 P711Q 711 P Q 0.842 Pathogenic MSH6 P52701 P711R 711 P R 0.98 Pathogenic MSH6 P52701 P711S 711 P S 0.346 Neutral MSH6 P52701 P711T 711 P T 0.708 Pathogenic MSH6 P52701 P711V 711 P V 0.84 Pathogenic MSH6 P52701 P711W 711 P W 0.94 Pathogenic MSH6 P52701 P711Y 711 P Y 0.94 Pathogenic MSH6 P52701 L712A 712 L A 0.242 Neutral MSH6 P52701 L712C 712 L C 0.298 Neutral MSH6 P52701 L712D 712 L D 0.554 Pathogenic MSH6 P52701 L712E 712 L E 0.518 Pathogenic MSH6 P52701 L712F 712 L F 0.728 Pathogenic MSH6 P52701 L712G 712 L G 0.538 Pathogenic MSH6 P52701 L712H 712 L H 0.298 Neutral MSH6 P52701 L712I 712 L I 0.018 Neutral MSH6 P52701 L712K 712 L K 0.434 Neutral MSH6 P52701 L712M 712 L M 0.22 Neutral MSH6 P52701 L712N 712 L N 0.54 Pathogenic MSH6 P52701 L712P 712 L P 0.162 Neutral MSH6 P52701 L712Q 712 L Q 0.256 Neutral MSH6 P52701 L712R 712 L R 0.764 Pathogenic MSH6 P52701 L712S 712 L S 0.054 Neutral MSH6 P52701 L712T 712 L T 0.392 Neutral MSH6 P52701 L712V 712 L V 0.016 Neutral MSH6 P52701 L712W 712 L W 0.784 Pathogenic MSH6 P52701 L712Y 712 L Y 0.766 Pathogenic MSH6 P52701 D713A 713 D A 0.356 Neutral MSH6 P52701 D713C 713 D C 0.646 Pathogenic MSH6 P52701 D713E 713 D E 0.126 Neutral MSH6 P52701 D713F 713 D F 0.792 Pathogenic MSH6 P52701 D713G 713 D G 0.276 Neutral MSH6 P52701 D713H 713 D H 0.066 Neutral MSH6 P52701 D713I 713 D I 0.722 Pathogenic MSH6 P52701 D713K 713 D K 0.592 Pathogenic MSH6 P52701 D713L 713 D L 0.716 Pathogenic MSH6 P52701 D713M 713 D M 0.64 Pathogenic MSH6 P52701 D713N 713 D N 0.058 Neutral MSH6 P52701 D713P 713 D P 0.186 Neutral MSH6 P52701 D713Q 713 D Q 0.05 Neutral MSH6 P52701 D713R 713 D R 0.55 Pathogenic MSH6 P52701 D713S 713 D S 0.286 Neutral MSH6 P52701 D713T 713 D T 0.472 Neutral MSH6 P52701 D713V 713 D V 0.752 Pathogenic MSH6 P52701 D713W 713 D W 0.874 Pathogenic MSH6 P52701 D713Y 713 D Y 0.856 Pathogenic MSH6 P52701 S714A 714 S A 0.01 Neutral MSH6 P52701 S714C 714 S C 0.032 Neutral MSH6 P52701 S714D 714 S D 0.026 Neutral MSH6 P52701 S714E 714 S E 0.138 Neutral MSH6 P52701 S714F 714 S F 0.27 Neutral MSH6 P52701 S714G 714 S G 0.036 Neutral MSH6 P52701 S714H 714 S H 0.242 Neutral MSH6 P52701 S714I 714 S I 0.194 Neutral MSH6 P52701 S714K 714 S K 0.146 Neutral MSH6 P52701 S714L 714 S L 0.034 Neutral MSH6 P52701 S714M 714 S M 0.304 Neutral MSH6 P52701 S714N 714 S N 0 Neutral MSH6 P52701 S714P 714 S P 0.056 Neutral MSH6 P52701 S714Q 714 S Q 0.17 Neutral MSH6 P52701 S714R 714 S R 0.176 Neutral MSH6 P52701 S714T 714 S T 0.02 Neutral MSH6 P52701 S714V 714 S V 0.03 Neutral MSH6 P52701 S714W 714 S W 0.502 Pathogenic MSH6 P52701 S714Y 714 S Y 0.448 Neutral MSH6 P52701 D715A 715 D A 0.02 Neutral MSH6 P52701 D715C 715 D C 0.256 Neutral MSH6 P52701 D715E 715 D E 0.012 Neutral MSH6 P52701 D715F 715 D F 0.62 Pathogenic MSH6 P52701 D715G 715 D G 0.092 Neutral MSH6 P52701 D715H 715 D H 0.03 Neutral MSH6 P52701 D715I 715 D I 0.432 Neutral MSH6 P52701 D715K 715 D K 0.068 Neutral MSH6 P52701 D715L 715 D L 0.092 Neutral MSH6 P52701 D715M 715 D M 0.334 Neutral MSH6 P52701 D715N 715 D N 0 Neutral MSH6 P52701 D715P 715 D P 0.46 Neutral MSH6 P52701 D715Q 715 D Q 0.014 Neutral MSH6 P52701 D715R 715 D R 0.34 Neutral MSH6 P52701 D715S 715 D S 0.002 Neutral MSH6 P52701 D715T 715 D T 0.044 Neutral MSH6 P52701 D715V 715 D V 0.248 Neutral MSH6 P52701 D715W 715 D W 0.706 Pathogenic MSH6 P52701 D715Y 715 D Y 0.678 Pathogenic MSH6 P52701 T716A 716 T A 0 Neutral MSH6 P52701 T716C 716 T C 0.064 Neutral MSH6 P52701 T716D 716 T D 0.024 Neutral MSH6 P52701 T716E 716 T E 0.032 Neutral MSH6 P52701 T716F 716 T F 0.196 Neutral MSH6 P52701 T716G 716 T G 0.002 Neutral MSH6 P52701 T716H 716 T H 0.084 Neutral MSH6 P52701 T716I 716 T I 0.036 Neutral MSH6 P52701 T716K 716 T K 0.002 Neutral MSH6 P52701 T716L 716 T L 0.008 Neutral MSH6 P52701 T716M 716 T M 0.026 Neutral MSH6 P52701 T716N 716 T N 0 Neutral MSH6 P52701 T716P 716 T P 0.084 Neutral MSH6 P52701 T716Q 716 T Q 0 Neutral MSH6 P52701 T716R 716 T R 0.156 Neutral MSH6 P52701 T716S 716 T S 0 Neutral MSH6 P52701 T716V 716 T V 0.016 Neutral MSH6 P52701 T716W 716 T W 0.466 Neutral MSH6 P52701 T716Y 716 T Y 0.424 Neutral MSH6 P52701 V717A 717 V A 0 Neutral MSH6 P52701 V717C 717 V C 0.058 Neutral MSH6 P52701 V717D 717 V D 0.026 Neutral MSH6 P52701 V717E 717 V E 0.044 Neutral MSH6 P52701 V717F 717 V F 0.172 Neutral MSH6 P52701 V717G 717 V G 0.038 Neutral MSH6 P52701 V717H 717 V H 0.112 Neutral MSH6 P52701 V717I 717 V I 0.004 Neutral MSH6 P52701 V717K 717 V K 0.068 Neutral MSH6 P52701 V717L 717 V L 0 Neutral MSH6 P52701 V717M 717 V M 0.034 Neutral MSH6 P52701 V717N 717 V N 0.038 Neutral MSH6 P52701 V717P 717 V P 0.038 Neutral MSH6 P52701 V717Q 717 V Q 0.1 Neutral MSH6 P52701 V717R 717 V R 0.226 Neutral MSH6 P52701 V717S 717 V S 0.01 Neutral MSH6 P52701 V717T 717 V T 0.008 Neutral MSH6 P52701 V717W 717 V W 0.344 Neutral MSH6 P52701 V717Y 717 V Y 0.256 Neutral MSH6 P52701 S718A 718 S A 0.01 Neutral MSH6 P52701 S718C 718 S C 0.032 Neutral MSH6 P52701 S718D 718 S D 0.002 Neutral MSH6 P52701 S718E 718 S E 0.148 Neutral MSH6 P52701 S718F 718 S F 0.302 Neutral MSH6 P52701 S718G 718 S G 0.036 Neutral MSH6 P52701 S718H 718 S H 0.264 Neutral MSH6 P52701 S718I 718 S I 0.142 Neutral MSH6 P52701 S718K 718 S K 0.172 Neutral MSH6 P52701 S718L 718 S L 0.034 Neutral MSH6 P52701 S718M 718 S M 0.384 Neutral MSH6 P52701 S718N 718 S N 0 Neutral MSH6 P52701 S718P 718 S P 0.07 Neutral MSH6 P52701 S718Q 718 S Q 0.194 Neutral MSH6 P52701 S718R 718 S R 0.148 Neutral MSH6 P52701 S718T 718 S T 0.02 Neutral MSH6 P52701 S718V 718 S V 0.034 Neutral MSH6 P52701 S718W 718 S W 0.532 Pathogenic MSH6 P52701 S718Y 718 S Y 0.488 Neutral MSH6 P52701 T719A 719 T A 0.002 Neutral MSH6 P52701 T719C 719 T C 0.004 Neutral MSH6 P52701 T719D 719 T D 0.02 Neutral MSH6 P52701 T719E 719 T E 0.024 Neutral MSH6 P52701 T719F 719 T F 0.194 Neutral MSH6 P52701 T719G 719 T G 0.002 Neutral MSH6 P52701 T719H 719 T H 0.084 Neutral MSH6 P52701 T719I 719 T I 0.096 Neutral MSH6 P52701 T719K 719 T K 0.002 Neutral MSH6 P52701 T719L 719 T L 0.008 Neutral MSH6 P52701 T719M 719 T M 0.048 Neutral MSH6 P52701 T719N 719 T N 0.052 Neutral MSH6 P52701 T719P 719 T P 0.008 Neutral MSH6 P52701 T719Q 719 T Q 0.01 Neutral MSH6 P52701 T719R 719 T R 0.14 Neutral MSH6 P52701 T719S 719 T S 0 Neutral MSH6 P52701 T719V 719 T V 0.046 Neutral MSH6 P52701 T719W 719 T W 0.466 Neutral MSH6 P52701 T719Y 719 T Y 0.424 Neutral MSH6 P52701 L72A 72 L A 0.06 Neutral MSH6 P52701 L72C 72 L C 0.094 Neutral MSH6 P52701 L72D 72 L D 0.158 Neutral MSH6 P52701 L72E 72 L E 0.144 Neutral MSH6 P52701 L72F 72 L F 0.242 Neutral MSH6 P52701 L72G 72 L G 0.184 Neutral MSH6 P52701 L72H 72 L H 0.084 Neutral MSH6 P52701 L72I 72 L I 0.03 Neutral MSH6 P52701 L72K 72 L K 0.02 Neutral MSH6 P52701 L72M 72 L M 0.132 Neutral MSH6 P52701 L72N 72 L N 0.148 Neutral MSH6 P52701 L72P 72 L P 0.224 Neutral MSH6 P52701 L72Q 72 L Q 0.048 Neutral MSH6 P52701 L72R 72 L R 0.218 Neutral MSH6 P52701 L72S 72 L S 0.204 Neutral MSH6 P52701 L72T 72 L T 0.18 Neutral MSH6 P52701 L72V 72 L V 0.08 Neutral MSH6 P52701 L72W 72 L W 0.27 Neutral MSH6 P52701 L72Y 72 L Y 0.284 Neutral MSH6 P52701 T720A 720 T A 0 Neutral MSH6 P52701 T720C 720 T C 0.03 Neutral MSH6 P52701 T720D 720 T D 0.046 Neutral MSH6 P52701 T720E 720 T E 0.024 Neutral MSH6 P52701 T720F 720 T F 0.214 Neutral MSH6 P52701 T720G 720 T G 0.002 Neutral MSH6 P52701 T720H 720 T H 0.056 Neutral MSH6 P52701 T720I 720 T I 0.042 Neutral MSH6 P52701 T720K 720 T K 0.002 Neutral MSH6 P52701 T720L 720 T L 0.008 Neutral MSH6 P52701 T720M 720 T M 0.032 Neutral MSH6 P52701 T720N 720 T N 0.012 Neutral MSH6 P52701 T720P 720 T P 0.056 Neutral MSH6 P52701 T720Q 720 T Q 0 Neutral MSH6 P52701 T720R 720 T R 0.142 Neutral MSH6 P52701 T720S 720 T S 0 Neutral MSH6 P52701 T720V 720 T V 0.016 Neutral MSH6 P52701 T720W 720 T W 0.466 Neutral MSH6 P52701 T720Y 720 T Y 0.308 Neutral MSH6 P52701 R721A 721 R A 0.036 Neutral MSH6 P52701 R721C 721 R C 0.14 Neutral MSH6 P52701 R721D 721 R D 0.02 Neutral MSH6 P52701 R721E 721 R E 0.02 Neutral MSH6 P52701 R721F 721 R F 0.036 Neutral MSH6 P52701 R721G 721 R G 0.002 Neutral MSH6 P52701 R721H 721 R H 0.142 Neutral MSH6 P52701 R721I 721 R I 0.304 Neutral MSH6 P52701 R721K 721 R K 0.004 Neutral MSH6 P52701 R721L 721 R L 0.272 Neutral MSH6 P52701 R721M 721 R M 0.164 Neutral MSH6 P52701 R721N 721 R N 0.198 Neutral MSH6 P52701 R721P 721 R P 0.236 Neutral MSH6 P52701 R721Q 721 R Q 0.028 Neutral MSH6 P52701 R721S 721 R S 0.016 Neutral MSH6 P52701 R721T 721 R T 0.016 Neutral MSH6 P52701 R721V 721 R V 0.032 Neutral MSH6 P52701 R721W 721 R W 0.384 Neutral MSH6 P52701 R721Y 721 R Y 0.284 Neutral MSH6 P52701 S722A 722 S A 0.01 Neutral MSH6 P52701 S722C 722 S C 0.032 Neutral MSH6 P52701 S722D 722 S D 0.002 Neutral MSH6 P52701 S722E 722 S E 0.146 Neutral MSH6 P52701 S722F 722 S F 0.302 Neutral MSH6 P52701 S722G 722 S G 0.036 Neutral MSH6 P52701 S722H 722 S H 0.264 Neutral MSH6 P52701 S722I 722 S I 0.206 Neutral MSH6 P52701 S722K 722 S K 0.156 Neutral MSH6 P52701 S722L 722 S L 0.052 Neutral MSH6 P52701 S722M 722 S M 0.384 Neutral MSH6 P52701 S722N 722 S N 0 Neutral MSH6 P52701 S722P 722 S P 0.062 Neutral MSH6 P52701 S722Q 722 S Q 0.178 Neutral MSH6 P52701 S722R 722 S R 0.146 Neutral MSH6 P52701 S722T 722 S T 0.02 Neutral MSH6 P52701 S722V 722 S V 0.302 Neutral MSH6 P52701 S722W 722 S W 0.532 Pathogenic MSH6 P52701 S722Y 722 S Y 0.488 Neutral MSH6 P52701 G723A 723 G A 0.002 Neutral MSH6 P52701 G723C 723 G C 0.144 Neutral MSH6 P52701 G723D 723 G D 0.134 Neutral MSH6 P52701 G723E 723 G E 0.19 Neutral MSH6 P52701 G723F 723 G F 0.516 Pathogenic MSH6 P52701 G723H 723 G H 0.394 Neutral MSH6 P52701 G723I 723 G I 0.43 Neutral MSH6 P52701 G723K 723 G K 0.288 Neutral MSH6 P52701 G723L 723 G L 0.322 Neutral MSH6 P52701 G723M 723 G M 0.324 Neutral MSH6 P52701 G723N 723 G N 0.178 Neutral MSH6 P52701 G723P 723 G P 0.376 Neutral MSH6 P52701 G723Q 723 G Q 0.186 Neutral MSH6 P52701 G723R 723 G R 0.486 Neutral MSH6 P52701 G723S 723 G S 0.012 Neutral MSH6 P52701 G723T 723 G T 0.264 Neutral MSH6 P52701 G723V 723 G V 0.312 Neutral MSH6 P52701 G723W 723 G W 0.516 Pathogenic MSH6 P52701 G723Y 723 G Y 0.512 Pathogenic MSH6 P52701 A724C 724 A C 0.106 Neutral MSH6 P52701 A724D 724 A D 0.436 Neutral MSH6 P52701 A724E 724 A E 0.42 Neutral MSH6 P52701 A724F 724 A F 0.378 Neutral MSH6 P52701 A724G 724 A G 0.012 Neutral MSH6 P52701 A724H 724 A H 0.5 Pathogenic MSH6 P52701 A724I 724 A I 0.476 Neutral MSH6 P52701 A724K 724 A K 0.426 Neutral MSH6 P52701 A724L 724 A L 0.41 Neutral MSH6 P52701 A724M 724 A M 0.454 Neutral MSH6 P52701 A724N 724 A N 0.394 Neutral MSH6 P52701 A724P 724 A P 0.076 Neutral MSH6 P52701 A724Q 724 A Q 0.462 Neutral MSH6 P52701 A724R 724 A R 0.46 Neutral MSH6 P52701 A724S 724 A S 0.012 Neutral MSH6 P52701 A724T 724 A T 0.028 Neutral MSH6 P52701 A724V 724 A V 0.058 Neutral MSH6 P52701 A724W 724 A W 0.742 Pathogenic MSH6 P52701 A724Y 724 A Y 0.456 Neutral MSH6 P52701 I725A 725 I A 0.012 Neutral MSH6 P52701 I725C 725 I C 0.126 Neutral MSH6 P52701 I725D 725 I D 0.038 Neutral MSH6 P52701 I725E 725 I E 0.044 Neutral MSH6 P52701 I725F 725 I F 0.094 Neutral MSH6 P52701 I725G 725 I G 0.116 Neutral MSH6 P52701 I725H 725 I H 0.152 Neutral MSH6 P52701 I725K 725 I K 0.05 Neutral MSH6 P52701 I725L 725 I L 0 Neutral MSH6 P52701 I725M 725 I M 0.232 Neutral MSH6 P52701 I725N 725 I N 0.11 Neutral MSH6 P52701 I725P 725 I P 0.196 Neutral MSH6 P52701 I725Q 725 I Q 0.11 Neutral MSH6 P52701 I725R 725 I R 0.346 Neutral MSH6 P52701 I725S 725 I S 0.078 Neutral MSH6 P52701 I725T 725 I T 0.008 Neutral MSH6 P52701 I725V 725 I V 0 Neutral MSH6 P52701 I725W 725 I W 0.548 Pathogenic MSH6 P52701 I725Y 725 I Y 0.506 Pathogenic MSH6 P52701 F726A 726 F A 0.162 Neutral MSH6 P52701 F726C 726 F C 0.048 Neutral MSH6 P52701 F726D 726 F D 0.546 Pathogenic MSH6 P52701 F726E 726 F E 0.104 Neutral MSH6 P52701 F726G 726 F G 0.396 Neutral MSH6 P52701 F726H 726 F H 0.024 Neutral MSH6 P52701 F726I 726 F I 0.078 Neutral MSH6 P52701 F726K 726 F K 0.074 Neutral MSH6 P52701 F726L 726 F L 0.024 Neutral MSH6 P52701 F726M 726 F M 0.282 Neutral MSH6 P52701 F726N 726 F N 0.082 Neutral MSH6 P52701 F726P 726 F P 0.622 Pathogenic MSH6 P52701 F726Q 726 F Q 0.1 Neutral MSH6 P52701 F726R 726 F R 0.556 Pathogenic MSH6 P52701 F726S 726 F S 0.064 Neutral MSH6 P52701 F726T 726 F T 0.27 Neutral MSH6 P52701 F726V 726 F V 0.078 Neutral MSH6 P52701 F726W 726 F W 0.806 Pathogenic MSH6 P52701 F726Y 726 F Y 0.152 Neutral MSH6 P52701 T727A 727 T A 0.032 Neutral MSH6 P52701 T727C 727 T C 0.048 Neutral MSH6 P52701 T727D 727 T D 0.146 Neutral MSH6 P52701 T727E 727 T E 0.108 Neutral MSH6 P52701 T727F 727 T F 0.646 Pathogenic MSH6 P52701 T727G 727 T G 0.028 Neutral MSH6 P52701 T727H 727 T H 0.196 Neutral MSH6 P52701 T727I 727 T I 0.302 Neutral MSH6 P52701 T727K 727 T K 0.068 Neutral MSH6 P52701 T727L 727 T L 0.066 Neutral MSH6 P52701 T727M 727 T M 0.49 Neutral MSH6 P52701 T727N 727 T N 0.008 Neutral MSH6 P52701 T727P 727 T P 0.494 Neutral MSH6 P52701 T727Q 727 T Q 0.222 Neutral MSH6 P52701 T727R 727 T R 0.402 Neutral MSH6 P52701 T727S 727 T S 0.01 Neutral MSH6 P52701 T727V 727 T V 0.164 Neutral MSH6 P52701 T727W 727 T W 0.9 Pathogenic MSH6 P52701 T727Y 727 T Y 0.888 Pathogenic MSH6 P52701 K728A 728 K A 0.086 Neutral MSH6 P52701 K728C 728 K C 0.064 Neutral MSH6 P52701 K728D 728 K D 0.002 Neutral MSH6 P52701 K728E 728 K E 0.056 Neutral MSH6 P52701 K728F 728 K F 0.106 Neutral MSH6 P52701 K728G 728 K G 0.048 Neutral MSH6 P52701 K728H 728 K H 0.008 Neutral MSH6 P52701 K728I 728 K I 0.394 Neutral MSH6 P52701 K728L 728 K L 0.094 Neutral MSH6 P52701 K728M 728 K M 0.186 Neutral MSH6 P52701 K728N 728 K N 0.008 Neutral MSH6 P52701 K728P 728 K P 0.08 Neutral MSH6 P52701 K728Q 728 K Q 0.01 Neutral MSH6 P52701 K728R 728 K R 0.006 Neutral MSH6 P52701 K728S 728 K S 0.016 Neutral MSH6 P52701 K728T 728 K T 0.024 Neutral MSH6 P52701 K728V 728 K V 0.342 Neutral MSH6 P52701 K728W 728 K W 0.68 Pathogenic MSH6 P52701 K728Y 728 K Y 0.204 Neutral MSH6 P52701 A729C 729 A C 0.156 Neutral MSH6 P52701 A729D 729 A D 0.316 Neutral MSH6 P52701 A729E 729 A E 0.286 Neutral MSH6 P52701 A729F 729 A F 0.34 Neutral MSH6 P52701 A729G 729 A G 0.008 Neutral MSH6 P52701 A729H 729 A H 0.234 Neutral MSH6 P52701 A729I 729 A I 0.446 Neutral MSH6 P52701 A729K 729 A K 0.254 Neutral MSH6 P52701 A729L 729 A L 0.318 Neutral MSH6 P52701 A729M 729 A M 0.29 Neutral MSH6 P52701 A729N 729 A N 0.296 Neutral MSH6 P52701 A729P 729 A P 0.3 Neutral MSH6 P52701 A729Q 729 A Q 0.26 Neutral MSH6 P52701 A729R 729 A R 0.298 Neutral MSH6 P52701 A729S 729 A S 0.006 Neutral MSH6 P52701 A729T 729 A T 0.012 Neutral MSH6 P52701 A729V 729 A V 0.04 Neutral MSH6 P52701 A729W 729 A W 0.354 Neutral MSH6 P52701 A729Y 729 A Y 0.37 Neutral MSH6 P52701 N73A 73 N A 0.004 Neutral MSH6 P52701 N73C 73 N C 0.158 Neutral MSH6 P52701 N73D 73 N D 0.118 Neutral MSH6 P52701 N73E 73 N E 0.096 Neutral MSH6 P52701 N73F 73 N F 0.34 Neutral MSH6 P52701 N73G 73 N G 0.162 Neutral MSH6 P52701 N73H 73 N H 0.23 Neutral MSH6 P52701 N73I 73 N I 0.266 Neutral MSH6 P52701 N73K 73 N K 0.272 Neutral MSH6 P52701 N73L 73 N L 0.172 Neutral MSH6 P52701 N73M 73 N M 0.22 Neutral MSH6 P52701 N73P 73 N P 0.158 Neutral MSH6 P52701 N73Q 73 N Q 0.166 Neutral MSH6 P52701 N73R 73 N R 0.136 Neutral MSH6 P52701 N73S 73 N S 0.076 Neutral MSH6 P52701 N73T 73 N T 0.08 Neutral MSH6 P52701 N73V 73 N V 0.28 Neutral MSH6 P52701 N73W 73 N W 0.446 Neutral MSH6 P52701 N73Y 73 N Y 0.402 Neutral MSH6 P52701 Y730A 730 Y A 0.082 Neutral MSH6 P52701 Y730C 730 Y C 0.112 Neutral MSH6 P52701 Y730D 730 Y D 0.034 Neutral MSH6 P52701 Y730E 730 Y E 0.112 Neutral MSH6 P52701 Y730F 730 Y F 0.058 Neutral MSH6 P52701 Y730G 730 Y G 0.122 Neutral MSH6 P52701 Y730H 730 Y H 0.052 Neutral MSH6 P52701 Y730I 730 Y I 0.094 Neutral MSH6 P52701 Y730K 730 Y K 0.04 Neutral MSH6 P52701 Y730L 730 Y L 0.064 Neutral MSH6 P52701 Y730M 730 Y M 0.076 Neutral MSH6 P52701 Y730N 730 Y N 0.07 Neutral MSH6 P52701 Y730P 730 Y P 0.064 Neutral MSH6 P52701 Y730Q 730 Y Q 0.064 Neutral MSH6 P52701 Y730R 730 Y R 0.032 Neutral MSH6 P52701 Y730S 730 Y S 0.096 Neutral MSH6 P52701 Y730T 730 Y T 0.126 Neutral MSH6 P52701 Y730V 730 Y V 0.22 Neutral MSH6 P52701 Y730W 730 Y W 0.048 Neutral MSH6 P52701 Q731A 731 Q A 0.168 Neutral MSH6 P52701 Q731C 731 Q C 0.106 Neutral MSH6 P52701 Q731D 731 Q D 0.14 Neutral MSH6 P52701 Q731E 731 Q E 0.092 Neutral MSH6 P52701 Q731F 731 Q F 0.418 Neutral MSH6 P52701 Q731G 731 Q G 0.176 Neutral MSH6 P52701 Q731H 731 Q H 0.35 Neutral MSH6 P52701 Q731I 731 Q I 0.44 Neutral MSH6 P52701 Q731K 731 Q K 0.024 Neutral MSH6 P52701 Q731L 731 Q L 0.482 Neutral MSH6 P52701 Q731M 731 Q M 0.326 Neutral MSH6 P52701 Q731N 731 Q N 0.022 Neutral MSH6 P52701 Q731P 731 Q P 0.456 Neutral MSH6 P52701 Q731R 731 Q R 0.006 Neutral MSH6 P52701 Q731S 731 Q S 0.044 Neutral MSH6 P52701 Q731T 731 Q T 0.19 Neutral MSH6 P52701 Q731V 731 Q V 0.076 Neutral MSH6 P52701 Q731W 731 Q W 0.676 Pathogenic MSH6 P52701 Q731Y 731 Q Y 0.604 Pathogenic MSH6 P52701 R732A 732 R A 0.35 Neutral MSH6 P52701 R732C 732 R C 0.604 Pathogenic MSH6 P52701 R732D 732 R D 0.602 Pathogenic MSH6 P52701 R732E 732 R E 0.508 Pathogenic MSH6 P52701 R732F 732 R F 0.818 Pathogenic MSH6 P52701 R732G 732 R G 0.248 Neutral MSH6 P52701 R732H 732 R H 0.02 Neutral MSH6 P52701 R732I 732 R I 0.818 Pathogenic MSH6 P52701 R732K 732 R K 0.036 Neutral MSH6 P52701 R732L 732 R L 0.806 Pathogenic MSH6 P52701 R732M 732 R M 0.596 Pathogenic MSH6 P52701 R732N 732 R N 0.032 Neutral MSH6 P52701 R732P 732 R P 0.752 Pathogenic MSH6 P52701 R732Q 732 R Q 0.038 Neutral MSH6 P52701 R732S 732 R S 0.05 Neutral MSH6 P52701 R732T 732 R T 0.56 Pathogenic MSH6 P52701 R732V 732 R V 0.748 Pathogenic MSH6 P52701 R732W 732 R W 0.824 Pathogenic MSH6 P52701 R732Y 732 R Y 0.118 Neutral MSH6 P52701 M733A 733 M A 0.274 Neutral MSH6 P52701 M733C 733 M C 0.618 Pathogenic MSH6 P52701 M733D 733 M D 0.878 Pathogenic MSH6 P52701 M733E 733 M E 0.816 Pathogenic MSH6 P52701 M733F 733 M F 0.87 Pathogenic MSH6 P52701 M733G 733 M G 0.536 Pathogenic MSH6 P52701 M733H 733 M H 0.936 Pathogenic MSH6 P52701 M733I 733 M I 0.84 Pathogenic MSH6 P52701 M733K 733 M K 0.958 Pathogenic MSH6 P52701 M733L 733 M L 0.238 Neutral MSH6 P52701 M733N 733 M N 0.906 Pathogenic MSH6 P52701 M733P 733 M P 0.932 Pathogenic MSH6 P52701 M733Q 733 M Q 0.79 Pathogenic MSH6 P52701 M733R 733 M R 0.958 Pathogenic MSH6 P52701 M733S 733 M S 0.9 Pathogenic MSH6 P52701 M733T 733 M T 0.774 Pathogenic MSH6 P52701 M733V 733 M V 0.16 Neutral MSH6 P52701 M733W 733 M W 0.988 Pathogenic MSH6 P52701 M733Y 733 M Y 0.976 Pathogenic MSH6 P52701 V734A 734 V A 0.164 Neutral MSH6 P52701 V734C 734 V C 0.798 Pathogenic MSH6 P52701 V734D 734 V D 0.852 Pathogenic MSH6 P52701 V734E 734 V E 0.954 Pathogenic MSH6 P52701 V734F 734 V F 0.932 Pathogenic MSH6 P52701 V734G 734 V G 0.922 Pathogenic MSH6 P52701 V734H 734 V H 0.898 Pathogenic MSH6 P52701 V734I 734 V I 0.258 Neutral MSH6 P52701 V734K 734 V K 0.974 Pathogenic MSH6 P52701 V734L 734 V L 0.326 Neutral MSH6 P52701 V734M 734 V M 0.908 Pathogenic MSH6 P52701 V734N 734 V N 0.912 Pathogenic MSH6 P52701 V734P 734 V P 0.988 Pathogenic MSH6 P52701 V734Q 734 V Q 0.96 Pathogenic MSH6 P52701 V734R 734 V R 0.944 Pathogenic MSH6 P52701 V734S 734 V S 0.808 Pathogenic MSH6 P52701 V734T 734 V T 0.408 Neutral MSH6 P52701 V734W 734 V W 0.956 Pathogenic MSH6 P52701 V734Y 734 V Y 0.976 Pathogenic MSH6 P52701 L735A 735 L A 0.718 Pathogenic MSH6 P52701 L735C 735 L C 0.824 Pathogenic MSH6 P52701 L735D 735 L D 0.908 Pathogenic MSH6 P52701 L735E 735 L E 0.89 Pathogenic MSH6 P52701 L735F 735 L F 0.794 Pathogenic MSH6 P52701 L735G 735 L G 0.872 Pathogenic MSH6 P52701 L735H 735 L H 0.91 Pathogenic MSH6 P52701 L735I 735 L I 0.428 Neutral MSH6 P52701 L735K 735 L K 0.72 Pathogenic MSH6 P52701 L735M 735 L M 0.344 Neutral MSH6 P52701 L735N 735 L N 0.818 Pathogenic MSH6 P52701 L735P 735 L P 0.986 Pathogenic MSH6 P52701 L735Q 735 L Q 0.772 Pathogenic MSH6 P52701 L735R 735 L R 0.986 Pathogenic MSH6 P52701 L735S 735 L S 0.708 Pathogenic MSH6 P52701 L735T 735 L T 0.624 Pathogenic MSH6 P52701 L735V 735 L V 0.266 Neutral MSH6 P52701 L735W 735 L W 0.874 Pathogenic MSH6 P52701 L735Y 735 L Y 0.886 Pathogenic MSH6 P52701 D736A 736 D A 0.784 Pathogenic MSH6 P52701 D736C 736 D C 0.868 Pathogenic MSH6 P52701 D736E 736 D E 0.806 Pathogenic MSH6 P52701 D736F 736 D F 0.974 Pathogenic MSH6 P52701 D736G 736 D G 0.92 Pathogenic MSH6 P52701 D736H 736 D H 0.622 Pathogenic MSH6 P52701 D736I 736 D I 0.962 Pathogenic MSH6 P52701 D736K 736 D K 0.92 Pathogenic MSH6 P52701 D736L 736 D L 0.964 Pathogenic MSH6 P52701 D736M 736 D M 0.948 Pathogenic MSH6 P52701 D736N 736 D N 0.378 Neutral MSH6 P52701 D736P 736 D P 0.892 Pathogenic MSH6 P52701 D736Q 736 D Q 0.612 Pathogenic MSH6 P52701 D736R 736 D R 0.956 Pathogenic MSH6 P52701 D736S 736 D S 0.558 Pathogenic MSH6 P52701 D736T 736 D T 0.788 Pathogenic MSH6 P52701 D736V 736 D V 0.982 Pathogenic MSH6 P52701 D736W 736 D W 0.978 Pathogenic MSH6 P52701 D736Y 736 D Y 0.972 Pathogenic MSH6 P52701 A737C 737 A C 0.976 Pathogenic MSH6 P52701 A737D 737 A D 0.726 Pathogenic MSH6 P52701 A737E 737 A E 0.976 Pathogenic MSH6 P52701 A737F 737 A F 0.994 Pathogenic MSH6 P52701 A737G 737 A G 0.208 Neutral MSH6 P52701 A737H 737 A H 0.942 Pathogenic MSH6 P52701 A737I 737 A I 0.96 Pathogenic MSH6 P52701 A737K 737 A K 0.972 Pathogenic MSH6 P52701 A737L 737 A L 1 Pathogenic MSH6 P52701 A737M 737 A M 0.908 Pathogenic MSH6 P52701 A737N 737 A N 0.566 Pathogenic MSH6 P52701 A737P 737 A P 0.978 Pathogenic MSH6 P52701 A737Q 737 A Q 0.9 Pathogenic MSH6 P52701 A737R 737 A R 0.982 Pathogenic MSH6 P52701 A737S 737 A S 0.122 Neutral MSH6 P52701 A737T 737 A T 0.9 Pathogenic MSH6 P52701 A737V 737 A V 0.862 Pathogenic MSH6 P52701 A737W 737 A W 0.996 Pathogenic MSH6 P52701 A737Y 737 A Y 0.966 Pathogenic MSH6 P52701 V738A 738 V A 0.014 Neutral MSH6 P52701 V738C 738 V C 0.394 Neutral MSH6 P52701 V738D 738 V D 0.602 Pathogenic MSH6 P52701 V738E 738 V E 0.706 Pathogenic MSH6 P52701 V738F 738 V F 0.62 Pathogenic MSH6 P52701 V738G 738 V G 0.628 Pathogenic MSH6 P52701 V738H 738 V H 0.236 Neutral MSH6 P52701 V738I 738 V I 0.046 Neutral MSH6 P52701 V738K 738 V K 0.34 Neutral MSH6 P52701 V738L 738 V L 0.058 Neutral MSH6 P52701 V738M 738 V M 0.146 Neutral MSH6 P52701 V738N 738 V N 0.49 Neutral MSH6 P52701 V738P 738 V P 0.692 Pathogenic MSH6 P52701 V738Q 738 V Q 0.136 Neutral MSH6 P52701 V738R 738 V R 0.838 Pathogenic MSH6 P52701 V738S 738 V S 0.442 Neutral MSH6 P52701 V738T 738 V T 0.022 Neutral MSH6 P52701 V738W 738 V W 0.84 Pathogenic MSH6 P52701 V738Y 738 V Y 0.83 Pathogenic MSH6 P52701 T739A 739 T A 0.174 Neutral MSH6 P52701 T739C 739 T C 0.254 Neutral MSH6 P52701 T739D 739 T D 0.934 Pathogenic MSH6 P52701 T739E 739 T E 0.948 Pathogenic MSH6 P52701 T739F 739 T F 0.946 Pathogenic MSH6 P52701 T739G 739 T G 0.714 Pathogenic MSH6 P52701 T739H 739 T H 0.908 Pathogenic MSH6 P52701 T739I 739 T I 0.946 Pathogenic MSH6 P52701 T739K 739 T K 0.934 Pathogenic MSH6 P52701 T739L 739 T L 0.942 Pathogenic MSH6 P52701 T739M 739 T M 0.982 Pathogenic MSH6 P52701 T739N 739 T N 0.87 Pathogenic MSH6 P52701 T739P 739 T P 0.956 Pathogenic MSH6 P52701 T739Q 739 T Q 0.868 Pathogenic MSH6 P52701 T739R 739 T R 0.986 Pathogenic MSH6 P52701 T739S 739 T S 0.142 Neutral MSH6 P52701 T739V 739 T V 0.694 Pathogenic MSH6 P52701 T739W 739 T W 0.994 Pathogenic MSH6 P52701 T739Y 739 T Y 0.994 Pathogenic MSH6 P52701 G74A 74 G A 0.018 Neutral MSH6 P52701 G74C 74 G C 0.14 Neutral MSH6 P52701 G74D 74 G D 0.244 Neutral MSH6 P52701 G74E 74 G E 0.304 Neutral MSH6 P52701 G74F 74 G F 0.498 Neutral MSH6 P52701 G74H 74 G H 0.442 Neutral MSH6 P52701 G74I 74 G I 0.412 Neutral MSH6 P52701 G74K 74 G K 0.284 Neutral MSH6 P52701 G74L 74 G L 0.412 Neutral MSH6 P52701 G74M 74 G M 0.422 Neutral MSH6 P52701 G74N 74 G N 0.162 Neutral MSH6 P52701 G74P 74 G P 0.392 Neutral MSH6 P52701 G74Q 74 G Q 0.194 Neutral MSH6 P52701 G74R 74 G R 0.324 Neutral MSH6 P52701 G74S 74 G S 0.018 Neutral MSH6 P52701 G74T 74 G T 0.274 Neutral MSH6 P52701 G74V 74 G V 0.394 Neutral MSH6 P52701 G74W 74 G W 0.498 Neutral MSH6 P52701 G74Y 74 G Y 0.5 Pathogenic MSH6 P52701 L740A 740 L A 0.714 Pathogenic MSH6 P52701 L740C 740 L C 0.822 Pathogenic MSH6 P52701 L740D 740 L D 0.91 Pathogenic MSH6 P52701 L740E 740 L E 0.894 Pathogenic MSH6 P52701 L740F 740 L F 0.87 Pathogenic MSH6 P52701 L740G 740 L G 0.864 Pathogenic MSH6 P52701 L740H 740 L H 0.91 Pathogenic MSH6 P52701 L740I 740 L I 0.396 Neutral MSH6 P52701 L740K 740 L K 0.724 Pathogenic MSH6 P52701 L740M 740 L M 0.422 Neutral MSH6 P52701 L740N 740 L N 0.82 Pathogenic MSH6 P52701 L740P 740 L P 0.992 Pathogenic MSH6 P52701 L740Q 740 L Q 0.776 Pathogenic MSH6 P52701 L740R 740 L R 0.986 Pathogenic MSH6 P52701 L740S 740 L S 0.706 Pathogenic MSH6 P52701 L740T 740 L T 0.626 Pathogenic MSH6 P52701 L740V 740 L V 0.416 Neutral MSH6 P52701 L740W 740 L W 0.874 Pathogenic MSH6 P52701 L740Y 740 L Y 0.886 Pathogenic MSH6 P52701 N741A 741 N A 0.048 Neutral MSH6 P52701 N741C 741 N C 0.552 Pathogenic MSH6 P52701 N741D 741 N D 0.294 Neutral MSH6 P52701 N741E 741 N E 0.046 Neutral MSH6 P52701 N741F 741 N F 0.778 Pathogenic MSH6 P52701 N741G 741 N G 0.556 Pathogenic MSH6 P52701 N741H 741 N H 0.354 Neutral MSH6 P52701 N741I 741 N I 0.32 Neutral MSH6 P52701 N741K 741 N K 0.07 Neutral MSH6 P52701 N741L 741 N L 0.768 Pathogenic MSH6 P52701 N741M 741 N M 0.092 Neutral MSH6 P52701 N741P 741 N P 0.634 Pathogenic MSH6 P52701 N741Q 741 N Q 0.06 Neutral MSH6 P52701 N741R 741 N R 0.352 Neutral MSH6 P52701 N741S 741 N S 0.044 Neutral MSH6 P52701 N741T 741 N T 0.036 Neutral MSH6 P52701 N741V 741 N V 0.088 Neutral MSH6 P52701 N741W 741 N W 0.882 Pathogenic MSH6 P52701 N741Y 741 N Y 0.668 Pathogenic MSH6 P52701 N742A 742 N A 0.792 Pathogenic MSH6 P52701 N742C 742 N C 0.768 Pathogenic MSH6 P52701 N742D 742 N D 0.736 Pathogenic MSH6 P52701 N742E 742 N E 0.614 Pathogenic MSH6 P52701 N742F 742 N F 0.956 Pathogenic MSH6 P52701 N742G 742 N G 0.47 Neutral MSH6 P52701 N742H 742 N H 0.57 Pathogenic MSH6 P52701 N742I 742 N I 0.938 Pathogenic MSH6 P52701 N742K 742 N K 0.86 Pathogenic MSH6 P52701 N742L 742 N L 0.95 Pathogenic MSH6 P52701 N742M 742 N M 0.952 Pathogenic MSH6 P52701 N742P 742 N P 0.862 Pathogenic MSH6 P52701 N742Q 742 N Q 0.802 Pathogenic MSH6 P52701 N742R 742 N R 0.948 Pathogenic MSH6 P52701 N742S 742 N S 0.718 Pathogenic MSH6 P52701 N742T 742 N T 0.536 Pathogenic MSH6 P52701 N742V 742 N V 0.978 Pathogenic MSH6 P52701 N742W 742 N W 0.97 Pathogenic MSH6 P52701 N742Y 742 N Y 0.966 Pathogenic MSH6 P52701 L743A 743 L A 0.712 Pathogenic MSH6 P52701 L743C 743 L C 0.822 Pathogenic MSH6 P52701 L743D 743 L D 0.91 Pathogenic MSH6 P52701 L743E 743 L E 0.894 Pathogenic MSH6 P52701 L743F 743 L F 0.804 Pathogenic MSH6 P52701 L743G 743 L G 0.862 Pathogenic MSH6 P52701 L743H 743 L H 0.908 Pathogenic MSH6 P52701 L743I 743 L I 0.94 Pathogenic MSH6 P52701 L743K 743 L K 0.718 Pathogenic MSH6 P52701 L743M 743 L M 0.35 Neutral MSH6 P52701 L743N 743 L N 0.82 Pathogenic MSH6 P52701 L743P 743 L P 0.994 Pathogenic MSH6 P52701 L743Q 743 L Q 0.562 Pathogenic MSH6 P52701 L743R 743 L R 0.984 Pathogenic MSH6 P52701 L743S 743 L S 0.694 Pathogenic MSH6 P52701 L743T 743 L T 0.618 Pathogenic MSH6 P52701 L743V 743 L V 0.43 Neutral MSH6 P52701 L743W 743 L W 0.882 Pathogenic MSH6 P52701 L743Y 743 L Y 0.89 Pathogenic MSH6 P52701 E744A 744 E A 0.764 Pathogenic MSH6 P52701 E744C 744 E C 0.716 Pathogenic MSH6 P52701 E744D 744 E D 0.172 Neutral MSH6 P52701 E744F 744 E F 0.972 Pathogenic MSH6 P52701 E744G 744 E G 0.152 Neutral MSH6 P52701 E744H 744 E H 0.466 Neutral MSH6 P52701 E744I 744 E I 0.98 Pathogenic MSH6 P52701 E744K 744 E K 0.41 Neutral MSH6 P52701 E744L 744 E L 0.98 Pathogenic MSH6 P52701 E744M 744 E M 0.926 Pathogenic MSH6 P52701 E744N 744 E N 0.114 Neutral MSH6 P52701 E744P 744 E P 0.936 Pathogenic MSH6 P52701 E744Q 744 E Q 0.79 Pathogenic MSH6 P52701 E744R 744 E R 0.32 Neutral MSH6 P52701 E744S 744 E S 0.342 Neutral MSH6 P52701 E744T 744 E T 0.886 Pathogenic MSH6 P52701 E744V 744 E V 0.918 Pathogenic MSH6 P52701 E744W 744 E W 0.986 Pathogenic MSH6 P52701 E744Y 744 E Y 0.966 Pathogenic MSH6 P52701 I745A 745 I A 0.602 Pathogenic MSH6 P52701 I745C 745 I C 0.686 Pathogenic MSH6 P52701 I745D 745 I D 0.756 Pathogenic MSH6 P52701 I745E 745 I E 0.756 Pathogenic MSH6 P52701 I745F 745 I F 0.924 Pathogenic MSH6 P52701 I745G 745 I G 0.824 Pathogenic MSH6 P52701 I745H 745 I H 0.902 Pathogenic MSH6 P52701 I745K 745 I K 0.848 Pathogenic MSH6 P52701 I745L 745 I L 0.056 Neutral MSH6 P52701 I745M 745 I M 0.368 Neutral MSH6 P52701 I745N 745 I N 0.778 Pathogenic MSH6 P52701 I745P 745 I P 0.934 Pathogenic MSH6 P52701 I745Q 745 I Q 0.788 Pathogenic MSH6 P52701 I745R 745 I R 0.864 Pathogenic MSH6 P52701 I745S 745 I S 0.354 Neutral MSH6 P52701 I745T 745 I T 0.332 Neutral MSH6 P52701 I745V 745 I V 0.098 Neutral MSH6 P52701 I745W 745 I W 0.966 Pathogenic MSH6 P52701 I745Y 745 I Y 0.946 Pathogenic MSH6 P52701 F746A 746 F A 0.214 Neutral MSH6 P52701 F746C 746 F C 0.584 Pathogenic MSH6 P52701 F746D 746 F D 0.814 Pathogenic MSH6 P52701 F746E 746 F E 0.894 Pathogenic MSH6 P52701 F746G 746 F G 0.492 Neutral MSH6 P52701 F746H 746 F H 0.648 Pathogenic MSH6 P52701 F746I 746 F I 0.118 Neutral MSH6 P52701 F746K 746 F K 0.862 Pathogenic MSH6 P52701 F746L 746 F L 0.082 Neutral MSH6 P52701 F746M 746 F M 0.264 Neutral MSH6 P52701 F746N 746 F N 0.732 Pathogenic MSH6 P52701 F746P 746 F P 0.924 Pathogenic MSH6 P52701 F746Q 746 F Q 0.764 Pathogenic MSH6 P52701 F746R 746 F R 0.932 Pathogenic MSH6 P52701 F746S 746 F S 0.742 Pathogenic MSH6 P52701 F746T 746 F T 0.356 Neutral MSH6 P52701 F746V 746 F V 0.164 Neutral MSH6 P52701 F746W 746 F W 0.918 Pathogenic MSH6 P52701 F746Y 746 F Y 0.666 Pathogenic MSH6 P52701 L747A 747 L A 0.012 Neutral MSH6 P52701 L747C 747 L C 0.024 Neutral MSH6 P52701 L747D 747 L D 0.28 Neutral MSH6 P52701 L747E 747 L E 0.044 Neutral MSH6 P52701 L747F 747 L F 0.44 Neutral MSH6 P52701 L747G 747 L G 0.282 Neutral MSH6 P52701 L747H 747 L H 0.05 Neutral MSH6 P52701 L747I 747 L I 0.124 Neutral MSH6 P52701 L747K 747 L K 0.052 Neutral MSH6 P52701 L747M 747 L M 0.278 Neutral MSH6 P52701 L747N 747 L N 0.04 Neutral MSH6 P52701 L747P 747 L P 0.112 Neutral MSH6 P52701 L747Q 747 L Q 0.012 Neutral MSH6 P52701 L747R 747 L R 0.364 Neutral MSH6 P52701 L747S 747 L S 0.016 Neutral MSH6 P52701 L747T 747 L T 0.024 Neutral MSH6 P52701 L747V 747 L V 0 Neutral MSH6 P52701 L747W 747 L W 0.544 Pathogenic MSH6 P52701 L747Y 747 L Y 0.392 Neutral MSH6 P52701 N748A 748 N A 0.378 Neutral MSH6 P52701 N748C 748 N C 0.802 Pathogenic MSH6 P52701 N748D 748 N D 0.312 Neutral MSH6 P52701 N748E 748 N E 0.656 Pathogenic MSH6 P52701 N748F 748 N F 0.934 Pathogenic MSH6 P52701 N748G 748 N G 0.402 Neutral MSH6 P52701 N748H 748 N H 0.948 Pathogenic MSH6 P52701 N748I 748 N I 0.95 Pathogenic MSH6 P52701 N748K 748 N K 0.986 Pathogenic MSH6 P52701 N748L 748 N L 0.968 Pathogenic MSH6 P52701 N748M 748 N M 0.974 Pathogenic MSH6 P52701 N748P 748 N P 0.444 Neutral MSH6 P52701 N748Q 748 N Q 0.628 Pathogenic MSH6 P52701 N748R 748 N R 0.924 Pathogenic MSH6 P52701 N748S 748 N S 0.236 Neutral MSH6 P52701 N748T 748 N T 0.336 Neutral MSH6 P52701 N748V 748 N V 0.99 Pathogenic MSH6 P52701 N748W 748 N W 0.978 Pathogenic MSH6 P52701 N748Y 748 N Y 0.974 Pathogenic MSH6 P52701 G749A 749 G A 0.068 Neutral MSH6 P52701 G749C 749 G C 0.804 Pathogenic MSH6 P52701 G749D 749 G D 0.682 Pathogenic MSH6 P52701 G749E 749 G E 0.842 Pathogenic MSH6 P52701 G749F 749 G F 0.974 Pathogenic MSH6 P52701 G749H 749 G H 0.974 Pathogenic MSH6 P52701 G749I 749 G I 0.694 Pathogenic MSH6 P52701 G749K 749 G K 0.978 Pathogenic MSH6 P52701 G749L 749 G L 0.622 Pathogenic MSH6 P52701 G749M 749 G M 0.986 Pathogenic MSH6 P52701 G749N 749 G N 0.48 Neutral MSH6 P52701 G749P 749 G P 0.78 Pathogenic MSH6 P52701 G749Q 749 G Q 0.87 Pathogenic MSH6 P52701 G749R 749 G R 0.992 Pathogenic MSH6 P52701 G749S 749 G S 0.144 Neutral MSH6 P52701 G749T 749 G T 0.576 Pathogenic MSH6 P52701 G749V 749 G V 0.974 Pathogenic MSH6 P52701 G749W 749 G W 0.964 Pathogenic MSH6 P52701 G749Y 749 G Y 0.958 Pathogenic MSH6 P52701 G75A 75 G A 0.018 Neutral MSH6 P52701 G75C 75 G C 0.14 Neutral MSH6 P52701 G75D 75 G D 0.154 Neutral MSH6 P52701 G75E 75 G E 0.304 Neutral MSH6 P52701 G75F 75 G F 0.498 Neutral MSH6 P52701 G75H 75 G H 0.442 Neutral MSH6 P52701 G75I 75 G I 0.428 Neutral MSH6 P52701 G75K 75 G K 0.286 Neutral MSH6 P52701 G75L 75 G L 0.37 Neutral MSH6 P52701 G75M 75 G M 0.422 Neutral MSH6 P52701 G75N 75 G N 0.172 Neutral MSH6 P52701 G75P 75 G P 0.392 Neutral MSH6 P52701 G75Q 75 G Q 0.18 Neutral MSH6 P52701 G75R 75 G R 0.286 Neutral MSH6 P52701 G75S 75 G S 0.186 Neutral MSH6 P52701 G75T 75 G T 0.274 Neutral MSH6 P52701 G75V 75 G V 0.39 Neutral MSH6 P52701 G75W 75 G W 0.498 Neutral MSH6 P52701 G75Y 75 G Y 0.5 Pathogenic MSH6 P52701 T750A 750 T A 0.002 Neutral MSH6 P52701 T750C 750 T C 0.096 Neutral MSH6 P52701 T750D 750 T D 0.028 Neutral MSH6 P52701 T750E 750 T E 0.178 Neutral MSH6 P52701 T750F 750 T F 0.344 Neutral MSH6 P52701 T750G 750 T G 0.078 Neutral MSH6 P52701 T750H 750 T H 0.182 Neutral MSH6 P52701 T750I 750 T I 0.202 Neutral MSH6 P52701 T750K 750 T K 0.162 Neutral MSH6 P52701 T750L 750 T L 0.022 Neutral MSH6 P52701 T750M 750 T M 0.294 Neutral MSH6 P52701 T750N 750 T N 0.088 Neutral MSH6 P52701 T750P 750 T P 0.244 Neutral MSH6 P52701 T750Q 750 T Q 0.11 Neutral MSH6 P52701 T750R 750 T R 0.304 Neutral MSH6 P52701 T750S 750 T S 0 Neutral MSH6 P52701 T750V 750 T V 0.02 Neutral MSH6 P52701 T750W 750 T W 0.774 Pathogenic MSH6 P52701 T750Y 750 T Y 0.476 Neutral MSH6 P52701 N751A 751 N A 0.096 Neutral MSH6 P52701 N751C 751 N C 0.13 Neutral MSH6 P52701 N751D 751 N D 0.008 Neutral MSH6 P52701 N751E 751 N E 0.012 Neutral MSH6 P52701 N751F 751 N F 0.594 Pathogenic MSH6 P52701 N751G 751 N G 0.02 Neutral MSH6 P52701 N751H 751 N H 0.374 Neutral MSH6 P52701 N751I 751 N I 0.44 Neutral MSH6 P52701 N751K 751 N K 0.192 Neutral MSH6 P52701 N751L 751 N L 0.444 Neutral MSH6 P52701 N751M 751 N M 0.376 Neutral MSH6 P52701 N751P 751 N P 0.19 Neutral MSH6 P52701 N751Q 751 N Q 0.192 Neutral MSH6 P52701 N751R 751 N R 0.236 Neutral MSH6 P52701 N751S 751 N S 0.008 Neutral MSH6 P52701 N751T 751 N T 0.008 Neutral MSH6 P52701 N751V 751 N V 0.454 Neutral MSH6 P52701 N751W 751 N W 0.724 Pathogenic MSH6 P52701 N751Y 751 N Y 0.588 Pathogenic MSH6 P52701 G752A 752 G A 0.89 Pathogenic MSH6 P52701 G752C 752 G C 0.922 Pathogenic MSH6 P52701 G752D 752 G D 0.514 Pathogenic MSH6 P52701 G752E 752 G E 0.62 Pathogenic MSH6 P52701 G752F 752 G F 0.988 Pathogenic MSH6 P52701 G752H 752 G H 0.692 Pathogenic MSH6 P52701 G752I 752 G I 0.812 Pathogenic MSH6 P52701 G752K 752 G K 0.772 Pathogenic MSH6 P52701 G752L 752 G L 0.988 Pathogenic MSH6 P52701 G752M 752 G M 0.994 Pathogenic MSH6 P52701 G752N 752 G N 0.5 Pathogenic MSH6 P52701 G752P 752 G P 0.932 Pathogenic MSH6 P52701 G752Q 752 G Q 0.57 Pathogenic MSH6 P52701 G752R 752 G R 1 Pathogenic MSH6 P52701 G752S 752 G S 0.37 Neutral MSH6 P52701 G752T 752 G T 0.718 Pathogenic MSH6 P52701 G752V 752 G V 0.914 Pathogenic MSH6 P52701 G752W 752 G W 0.982 Pathogenic MSH6 P52701 G752Y 752 G Y 0.912 Pathogenic MSH6 P52701 S753A 753 S A 0.06 Neutral MSH6 P52701 S753C 753 S C 0.342 Neutral MSH6 P52701 S753D 753 S D 0.37 Neutral MSH6 P52701 S753E 753 S E 0.48 Neutral MSH6 P52701 S753F 753 S F 0.604 Pathogenic MSH6 P52701 S753G 753 S G 0.018 Neutral MSH6 P52701 S753H 753 S H 0.8 Pathogenic MSH6 P52701 S753I 753 S I 0.6 Pathogenic MSH6 P52701 S753K 753 S K 0.438 Neutral MSH6 P52701 S753L 753 S L 0.158 Neutral MSH6 P52701 S753M 753 S M 0.976 Pathogenic MSH6 P52701 S753N 753 S N 0.06 Neutral MSH6 P52701 S753P 753 S P 0.606 Pathogenic MSH6 P52701 S753Q 753 S Q 0.582 Pathogenic MSH6 P52701 S753R 753 S R 0.588 Pathogenic MSH6 P52701 S753T 753 S T 0.054 Neutral MSH6 P52701 S753V 753 S V 0.24 Neutral MSH6 P52701 S753W 753 S W 0.952 Pathogenic MSH6 P52701 S753Y 753 S Y 0.916 Pathogenic MSH6 P52701 T754A 754 T A 0.01 Neutral MSH6 P52701 T754C 754 T C 0.25 Neutral MSH6 P52701 T754D 754 T D 0.084 Neutral MSH6 P52701 T754E 754 T E 0.062 Neutral MSH6 P52701 T754F 754 T F 0.56 Pathogenic MSH6 P52701 T754G 754 T G 0.158 Neutral MSH6 P52701 T754H 754 T H 0.108 Neutral MSH6 P52701 T754I 754 T I 0.074 Neutral MSH6 P52701 T754K 754 T K 0.168 Neutral MSH6 P52701 T754L 754 T L 0.028 Neutral MSH6 P52701 T754M 754 T M 0.438 Neutral MSH6 P52701 T754N 754 T N 0.208 Neutral MSH6 P52701 T754P 754 T P 0.036 Neutral MSH6 P52701 T754Q 754 T Q 0.008 Neutral MSH6 P52701 T754R 754 T R 0.336 Neutral MSH6 P52701 T754S 754 T S 0.01 Neutral MSH6 P52701 T754V 754 T V 0.05 Neutral MSH6 P52701 T754W 754 T W 0.856 Pathogenic MSH6 P52701 T754Y 754 T Y 0.828 Pathogenic MSH6 P52701 E755A 755 E A 0.384 Neutral MSH6 P52701 E755C 755 E C 0.444 Neutral MSH6 P52701 E755D 755 E D 0.028 Neutral MSH6 P52701 E755F 755 E F 0.804 Pathogenic MSH6 P52701 E755G 755 E G 0.154 Neutral MSH6 P52701 E755H 755 E H 0.388 Neutral MSH6 P52701 E755I 755 E I 0.24 Neutral MSH6 P52701 E755K 755 E K 0.056 Neutral MSH6 P52701 E755L 755 E L 0.138 Neutral MSH6 P52701 E755M 755 E M 0.388 Neutral MSH6 P52701 E755N 755 E N 0.03 Neutral MSH6 P52701 E755P 755 E P 0.856 Pathogenic MSH6 P52701 E755Q 755 E Q 0.024 Neutral MSH6 P52701 E755R 755 E R 0.36 Neutral MSH6 P52701 E755S 755 E S 0.038 Neutral MSH6 P52701 E755T 755 E T 0.128 Neutral MSH6 P52701 E755V 755 E V 0.816 Pathogenic MSH6 P52701 E755W 755 E W 0.94 Pathogenic MSH6 P52701 E755Y 755 E Y 0.886 Pathogenic MSH6 P52701 G756A 756 G A 0.382 Neutral MSH6 P52701 G756C 756 G C 0.936 Pathogenic MSH6 P52701 G756D 756 G D 0.722 Pathogenic MSH6 P52701 G756E 756 G E 0.984 Pathogenic MSH6 P52701 G756F 756 G F 0.988 Pathogenic MSH6 P52701 G756H 756 G H 0.992 Pathogenic MSH6 P52701 G756I 756 G I 0.978 Pathogenic MSH6 P52701 G756K 756 G K 0.698 Pathogenic MSH6 P52701 G756L 756 G L 0.73 Pathogenic MSH6 P52701 G756M 756 G M 0.994 Pathogenic MSH6 P52701 G756N 756 G N 0.514 Pathogenic MSH6 P52701 G756P 756 G P 0.982 Pathogenic MSH6 P52701 G756Q 756 G Q 0.734 Pathogenic MSH6 P52701 G756R 756 G R 1 Pathogenic MSH6 P52701 G756S 756 G S 0.334 Neutral MSH6 P52701 G756T 756 G T 0.646 Pathogenic MSH6 P52701 G756V 756 G V 0.92 Pathogenic MSH6 P52701 G756W 756 G W 0.984 Pathogenic MSH6 P52701 G756Y 756 G Y 0.78 Pathogenic MSH6 P52701 T757A 757 T A 0.182 Neutral MSH6 P52701 T757C 757 T C 0.898 Pathogenic MSH6 P52701 T757D 757 T D 0.916 Pathogenic MSH6 P52701 T757E 757 T E 0.942 Pathogenic MSH6 P52701 T757F 757 T F 0.938 Pathogenic MSH6 P52701 T757G 757 T G 0.674 Pathogenic MSH6 P52701 T757H 757 T H 0.894 Pathogenic MSH6 P52701 T757I 757 T I 0.626 Pathogenic MSH6 P52701 T757K 757 T K 0.922 Pathogenic MSH6 P52701 T757L 757 T L 0.618 Pathogenic MSH6 P52701 T757M 757 T M 0.978 Pathogenic MSH6 P52701 T757N 757 T N 0.846 Pathogenic MSH6 P52701 T757P 757 T P 0.948 Pathogenic MSH6 P52701 T757Q 757 T Q 0.85 Pathogenic MSH6 P52701 T757R 757 T R 0.718 Pathogenic MSH6 P52701 T757S 757 T S 0.116 Neutral MSH6 P52701 T757V 757 T V 0.378 Neutral MSH6 P52701 T757W 757 T W 0.994 Pathogenic MSH6 P52701 T757Y 757 T Y 0.994 Pathogenic MSH6 P52701 L758A 758 L A 0.702 Pathogenic MSH6 P52701 L758C 758 L C 0.398 Neutral MSH6 P52701 L758D 758 L D 0.884 Pathogenic MSH6 P52701 L758E 758 L E 0.866 Pathogenic MSH6 P52701 L758F 758 L F 0.832 Pathogenic MSH6 P52701 L758G 758 L G 0.858 Pathogenic MSH6 P52701 L758H 758 L H 0.898 Pathogenic MSH6 P52701 L758I 758 L I 0.396 Neutral MSH6 P52701 L758K 758 L K 0.242 Neutral MSH6 P52701 L758M 758 L M 0.344 Neutral MSH6 P52701 L758N 758 L N 0.796 Pathogenic MSH6 P52701 L758P 758 L P 0.966 Pathogenic MSH6 P52701 L758Q 758 L Q 0.756 Pathogenic MSH6 P52701 L758R 758 L R 0.974 Pathogenic MSH6 P52701 L758S 758 L S 0.682 Pathogenic MSH6 P52701 L758T 758 L T 0.6 Pathogenic MSH6 P52701 L758V 758 L V 0.092 Neutral MSH6 P52701 L758W 758 L W 0.848 Pathogenic MSH6 P52701 L758Y 758 L Y 0.87 Pathogenic MSH6 P52701 L759A 759 L A 0.13 Neutral MSH6 P52701 L759C 759 L C 0.372 Neutral MSH6 P52701 L759D 759 L D 0.648 Pathogenic MSH6 P52701 L759E 759 L E 0.6 Pathogenic MSH6 P52701 L759F 759 L F 0.278 Neutral MSH6 P52701 L759G 759 L G 0.568 Pathogenic MSH6 P52701 L759H 759 L H 0.076 Neutral MSH6 P52701 L759I 759 L I 0.044 Neutral MSH6 P52701 L759K 759 L K 0.472 Neutral MSH6 P52701 L759M 759 L M 0.46 Neutral MSH6 P52701 L759N 759 L N 0.598 Pathogenic MSH6 P52701 L759P 759 L P 0.95 Pathogenic MSH6 P52701 L759Q 759 L Q 0.192 Neutral MSH6 P52701 L759R 759 L R 0.864 Pathogenic MSH6 P52701 L759S 759 L S 0.404 Neutral MSH6 P52701 L759T 759 L T 0.386 Neutral MSH6 P52701 L759V 759 L V 0.154 Neutral MSH6 P52701 L759W 759 L W 0.602 Pathogenic MSH6 P52701 L759Y 759 L Y 0.618 Pathogenic MSH6 P52701 L76A 76 L A 0.06 Neutral MSH6 P52701 L76C 76 L C 0.056 Neutral MSH6 P52701 L76D 76 L D 0.158 Neutral MSH6 P52701 L76E 76 L E 0.144 Neutral MSH6 P52701 L76F 76 L F 0.204 Neutral MSH6 P52701 L76G 76 L G 0.186 Neutral MSH6 P52701 L76H 76 L H 0.084 Neutral MSH6 P52701 L76I 76 L I 0.072 Neutral MSH6 P52701 L76K 76 L K 0.022 Neutral MSH6 P52701 L76M 76 L M 0.132 Neutral MSH6 P52701 L76N 76 L N 0.148 Neutral MSH6 P52701 L76P 76 L P 0.136 Neutral MSH6 P52701 L76Q 76 L Q 0.048 Neutral MSH6 P52701 L76R 76 L R 0.232 Neutral MSH6 P52701 L76S 76 L S 0.204 Neutral MSH6 P52701 L76T 76 L T 0.112 Neutral MSH6 P52701 L76V 76 L V 0.114 Neutral MSH6 P52701 L76W 76 L W 0.334 Neutral MSH6 P52701 L76Y 76 L Y 0.284 Neutral MSH6 P52701 E760A 760 E A 0.106 Neutral MSH6 P52701 E760C 760 E C 0.178 Neutral MSH6 P52701 E760D 760 E D 0.004 Neutral MSH6 P52701 E760F 760 E F 0.56 Pathogenic MSH6 P52701 E760G 760 E G 0.042 Neutral MSH6 P52701 E760H 760 E H 0.018 Neutral MSH6 P52701 E760I 760 E I 0.526 Pathogenic MSH6 P52701 E760K 760 E K 0.014 Neutral MSH6 P52701 E760L 760 E L 0.528 Pathogenic MSH6 P52701 E760M 760 E M 0.358 Neutral MSH6 P52701 E760N 760 E N 0.004 Neutral MSH6 P52701 E760P 760 E P 0.538 Pathogenic MSH6 P52701 E760Q 760 E Q 0.002 Neutral MSH6 P52701 E760R 760 E R 0.046 Neutral MSH6 P52701 E760S 760 E S 0.022 Neutral MSH6 P52701 E760T 760 E T 0.02 Neutral MSH6 P52701 E760V 760 E V 0.25 Neutral MSH6 P52701 E760W 760 E W 0.772 Pathogenic MSH6 P52701 E760Y 760 E Y 0.352 Neutral MSH6 P52701 R761A 761 R A 0.368 Neutral MSH6 P52701 R761C 761 R C 0.614 Pathogenic MSH6 P52701 R761D 761 R D 0.61 Pathogenic MSH6 P52701 R761E 761 R E 0.566 Pathogenic MSH6 P52701 R761F 761 R F 0.45 Neutral MSH6 P52701 R761G 761 R G 0.238 Neutral MSH6 P52701 R761H 761 R H 0.102 Neutral MSH6 P52701 R761I 761 R I 0.172 Neutral MSH6 P52701 R761K 761 R K 0.028 Neutral MSH6 P52701 R761L 761 R L 0.092 Neutral MSH6 P52701 R761M 761 R M 0.044 Neutral MSH6 P52701 R761N 761 R N 0.544 Pathogenic MSH6 P52701 R761P 761 R P 0.774 Pathogenic MSH6 P52701 R761Q 761 R Q 0.02 Neutral MSH6 P52701 R761S 761 R S 0.446 Neutral MSH6 P52701 R761T 761 R T 0.046 Neutral MSH6 P52701 R761V 761 R V 0.094 Neutral MSH6 P52701 R761W 761 R W 0.842 Pathogenic MSH6 P52701 R761Y 761 R Y 0.466 Neutral MSH6 P52701 V762A 762 V A 0.328 Neutral MSH6 P52701 V762C 762 V C 0.688 Pathogenic MSH6 P52701 V762D 762 V D 0.862 Pathogenic MSH6 P52701 V762E 762 V E 0.974 Pathogenic MSH6 P52701 V762F 762 V F 0.86 Pathogenic MSH6 P52701 V762G 762 V G 0.902 Pathogenic MSH6 P52701 V762H 762 V H 0.792 Pathogenic MSH6 P52701 V762I 762 V I 0.148 Neutral MSH6 P52701 V762K 762 V K 0.96 Pathogenic MSH6 P52701 V762L 762 V L 0.196 Neutral MSH6 P52701 V762M 762 V M 0.206 Neutral MSH6 P52701 V762N 762 V N 0.93 Pathogenic MSH6 P52701 V762P 762 V P 0.962 Pathogenic MSH6 P52701 V762Q 762 V Q 0.988 Pathogenic MSH6 P52701 V762R 762 V R 0.956 Pathogenic MSH6 P52701 V762S 762 V S 0.734 Pathogenic MSH6 P52701 V762T 762 V T 0.726 Pathogenic MSH6 P52701 V762W 762 V W 0.898 Pathogenic MSH6 P52701 V762Y 762 V Y 0.92 Pathogenic MSH6 P52701 D763A 763 D A 0.34 Neutral MSH6 P52701 D763C 763 D C 0.252 Neutral MSH6 P52701 D763E 763 D E 0.316 Neutral MSH6 P52701 D763F 763 D F 0.902 Pathogenic MSH6 P52701 D763G 763 D G 0.888 Pathogenic MSH6 P52701 D763H 763 D H 0.612 Pathogenic MSH6 P52701 D763I 763 D I 0.97 Pathogenic MSH6 P52701 D763K 763 D K 0.972 Pathogenic MSH6 P52701 D763L 763 D L 0.978 Pathogenic MSH6 P52701 D763M 763 D M 0.946 Pathogenic MSH6 P52701 D763N 763 D N 0.072 Neutral MSH6 P52701 D763P 763 D P 0.908 Pathogenic MSH6 P52701 D763Q 763 D Q 0.768 Pathogenic MSH6 P52701 D763R 763 D R 0.906 Pathogenic MSH6 P52701 D763S 763 D S 0.696 Pathogenic MSH6 P52701 D763T 763 D T 0.83 Pathogenic MSH6 P52701 D763V 763 D V 0.992 Pathogenic MSH6 P52701 D763W 763 D W 0.986 Pathogenic MSH6 P52701 D763Y 763 D Y 0.98 Pathogenic MSH6 P52701 T764A 764 T A 0.408 Neutral MSH6 P52701 T764C 764 T C 0.454 Neutral MSH6 P52701 T764D 764 T D 0.47 Neutral MSH6 P52701 T764E 764 T E 0.56 Pathogenic MSH6 P52701 T764F 764 T F 0.446 Neutral MSH6 P52701 T764G 764 T G 0.272 Neutral MSH6 P52701 T764H 764 T H 0.194 Neutral MSH6 P52701 T764I 764 T I 0.46 Neutral MSH6 P52701 T764K 764 T K 0.092 Neutral MSH6 P52701 T764L 764 T L 0.182 Neutral MSH6 P52701 T764M 764 T M 0.53 Pathogenic MSH6 P52701 T764N 764 T N 0.022 Neutral MSH6 P52701 T764P 764 T P 0.6 Pathogenic MSH6 P52701 T764Q 764 T Q 0.028 Neutral MSH6 P52701 T764R 764 T R 0.444 Neutral MSH6 P52701 T764S 764 T S 0.024 Neutral MSH6 P52701 T764V 764 T V 0.736 Pathogenic MSH6 P52701 T764W 764 T W 0.914 Pathogenic MSH6 P52701 T764Y 764 T Y 0.61 Pathogenic MSH6 P52701 C765A 765 C A 0.292 Neutral MSH6 P52701 C765D 765 C D 0.928 Pathogenic MSH6 P52701 C765E 765 C E 0.79 Pathogenic MSH6 P52701 C765F 765 C F 0.942 Pathogenic MSH6 P52701 C765G 765 C G 0.9 Pathogenic MSH6 P52701 C765H 765 C H 0.75 Pathogenic MSH6 P52701 C765I 765 C I 0.926 Pathogenic MSH6 P52701 C765K 765 C K 0.716 Pathogenic MSH6 P52701 C765L 765 C L 0.734 Pathogenic MSH6 P52701 C765M 765 C M 0.64 Pathogenic MSH6 P52701 C765N 765 C N 0.788 Pathogenic MSH6 P52701 C765P 765 C P 0.952 Pathogenic MSH6 P52701 C765Q 765 C Q 0.492 Neutral MSH6 P52701 C765R 765 C R 0.996 Pathogenic MSH6 P52701 C765S 765 C S 0.086 Neutral MSH6 P52701 C765T 765 C T 0.08 Neutral MSH6 P52701 C765V 765 C V 0.932 Pathogenic MSH6 P52701 C765W 765 C W 0.954 Pathogenic MSH6 P52701 C765Y 765 C Y 0.94 Pathogenic MSH6 P52701 H766A 766 H A 0.098 Neutral MSH6 P52701 H766C 766 H C 0.022 Neutral MSH6 P52701 H766D 766 H D 0.224 Neutral MSH6 P52701 H766E 766 H E 0.266 Neutral MSH6 P52701 H766F 766 H F 0.406 Neutral MSH6 P52701 H766G 766 H G 0.288 Neutral MSH6 P52701 H766I 766 H I 0.068 Neutral MSH6 P52701 H766K 766 H K 0.03 Neutral MSH6 P52701 H766L 766 H L 0.368 Neutral MSH6 P52701 H766M 766 H M 0.344 Neutral MSH6 P52701 H766N 766 H N 0.062 Neutral MSH6 P52701 H766P 766 H P 0.868 Pathogenic MSH6 P52701 H766Q 766 H Q 0.022 Neutral MSH6 P52701 H766R 766 H R 0.008 Neutral MSH6 P52701 H766S 766 H S 0.026 Neutral MSH6 P52701 H766T 766 H T 0.022 Neutral MSH6 P52701 H766V 766 H V 0.056 Neutral MSH6 P52701 H766W 766 H W 0.898 Pathogenic MSH6 P52701 H766Y 766 H Y 0.756 Pathogenic MSH6 P52701 T767A 767 T A 0.7 Pathogenic MSH6 P52701 T767C 767 T C 0.926 Pathogenic MSH6 P52701 T767D 767 T D 0.936 Pathogenic MSH6 P52701 T767E 767 T E 0.944 Pathogenic MSH6 P52701 T767F 767 T F 0.736 Pathogenic MSH6 P52701 T767G 767 T G 0.744 Pathogenic MSH6 P52701 T767H 767 T H 0.918 Pathogenic MSH6 P52701 T767I 767 T I 0.944 Pathogenic MSH6 P52701 T767K 767 T K 0.934 Pathogenic MSH6 P52701 T767L 767 T L 0.94 Pathogenic MSH6 P52701 T767M 767 T M 0.976 Pathogenic MSH6 P52701 T767N 767 T N 0.886 Pathogenic MSH6 P52701 T767P 767 T P 0.956 Pathogenic MSH6 P52701 T767Q 767 T Q 0.89 Pathogenic MSH6 P52701 T767R 767 T R 0.74 Pathogenic MSH6 P52701 T767S 767 T S 0.236 Neutral MSH6 P52701 T767V 767 T V 0.814 Pathogenic MSH6 P52701 T767W 767 T W 0.962 Pathogenic MSH6 P52701 T767Y 767 T Y 0.962 Pathogenic MSH6 P52701 P768A 768 P A 0.114 Neutral MSH6 P52701 P768C 768 P C 0.7 Pathogenic MSH6 P52701 P768D 768 P D 0.54 Pathogenic MSH6 P52701 P768E 768 P E 0.786 Pathogenic MSH6 P52701 P768F 768 P F 0.704 Pathogenic MSH6 P52701 P768G 768 P G 0.084 Neutral MSH6 P52701 P768H 768 P H 0.738 Pathogenic MSH6 P52701 P768I 768 P I 0.616 Pathogenic MSH6 P52701 P768K 768 P K 0.178 Neutral MSH6 P52701 P768L 768 P L 0.212 Neutral MSH6 P52701 P768M 768 P M 0.584 Pathogenic MSH6 P52701 P768N 768 P N 0.122 Neutral MSH6 P52701 P768Q 768 P Q 0.3 Neutral MSH6 P52701 P768R 768 P R 0.718 Pathogenic MSH6 P52701 P768S 768 P S 0.058 Neutral MSH6 P52701 P768T 768 P T 0.49 Neutral MSH6 P52701 P768V 768 P V 0.644 Pathogenic MSH6 P52701 P768W 768 P W 0.878 Pathogenic MSH6 P52701 P768Y 768 P Y 0.854 Pathogenic MSH6 P52701 F769A 769 F A 0.208 Neutral MSH6 P52701 F769C 769 F C 0.708 Pathogenic MSH6 P52701 F769D 769 F D 0.782 Pathogenic MSH6 P52701 F769E 769 F E 0.826 Pathogenic MSH6 P52701 F769G 769 F G 0.324 Neutral MSH6 P52701 F769H 769 F H 0.212 Neutral MSH6 P52701 F769I 769 F I 0.662 Pathogenic MSH6 P52701 F769K 769 F K 0.806 Pathogenic MSH6 P52701 F769L 769 F L 0.678 Pathogenic MSH6 P52701 F769M 769 F M 0.214 Neutral MSH6 P52701 F769N 769 F N 0.726 Pathogenic MSH6 P52701 F769P 769 F P 0.49 Neutral MSH6 P52701 F769Q 769 F Q 0.736 Pathogenic MSH6 P52701 F769R 769 F R 0.876 Pathogenic MSH6 P52701 F769S 769 F S 0.184 Neutral MSH6 P52701 F769T 769 F T 0.21 Neutral MSH6 P52701 F769V 769 F V 0.686 Pathogenic MSH6 P52701 F769W 769 F W 0.83 Pathogenic MSH6 P52701 F769Y 769 F Y 0.492 Neutral MSH6 P52701 R77A 77 R A 0.064 Neutral MSH6 P52701 R77C 77 R C 0.148 Neutral MSH6 P52701 R77D 77 R D 0.18 Neutral MSH6 P52701 R77E 77 R E 0.128 Neutral MSH6 P52701 R77F 77 R F 0.036 Neutral MSH6 P52701 R77G 77 R G 0.002 Neutral MSH6 P52701 R77H 77 R H 0.12 Neutral MSH6 P52701 R77I 77 R I 0.304 Neutral MSH6 P52701 R77K 77 R K 0.172 Neutral MSH6 P52701 R77L 77 R L 0.23 Neutral MSH6 P52701 R77M 77 R M 0.164 Neutral MSH6 P52701 R77N 77 R N 0.198 Neutral MSH6 P52701 R77P 77 R P 0.236 Neutral MSH6 P52701 R77Q 77 R Q 0.25 Neutral MSH6 P52701 R77S 77 R S 0.164 Neutral MSH6 P52701 R77T 77 R T 0.066 Neutral MSH6 P52701 R77V 77 R V 0.242 Neutral MSH6 P52701 R77W 77 R W 0.384 Neutral MSH6 P52701 R77Y 77 R Y 0.284 Neutral MSH6 P52701 G770A 770 G A 0.966 Pathogenic MSH6 P52701 G770C 770 G C 0.946 Pathogenic MSH6 P52701 G770D 770 G D 0.798 Pathogenic MSH6 P52701 G770E 770 G E 0.986 Pathogenic MSH6 P52701 G770F 770 G F 0.98 Pathogenic MSH6 P52701 G770H 770 G H 0.984 Pathogenic MSH6 P52701 G770I 770 G I 0.972 Pathogenic MSH6 P52701 G770K 770 G K 0.984 Pathogenic MSH6 P52701 G770L 770 G L 0.982 Pathogenic MSH6 P52701 G770M 770 G M 0.994 Pathogenic MSH6 P52701 G770N 770 G N 0.986 Pathogenic MSH6 P52701 G770P 770 G P 0.962 Pathogenic MSH6 P52701 G770Q 770 G Q 0.994 Pathogenic MSH6 P52701 G770R 770 G R 1 Pathogenic MSH6 P52701 G770S 770 G S 0.824 Pathogenic MSH6 P52701 G770T 770 G T 0.838 Pathogenic MSH6 P52701 G770V 770 G V 0.984 Pathogenic MSH6 P52701 G770W 770 G W 0.976 Pathogenic MSH6 P52701 G770Y 770 G Y 0.956 Pathogenic MSH6 P52701 K771A 771 K A 0.24 Neutral MSH6 P52701 K771C 771 K C 0.582 Pathogenic MSH6 P52701 K771D 771 K D 0.768 Pathogenic MSH6 P52701 K771E 771 K E 0.874 Pathogenic MSH6 P52701 K771F 771 K F 0.964 Pathogenic MSH6 P52701 K771G 771 K G 0.312 Neutral MSH6 P52701 K771H 771 K H 0.874 Pathogenic MSH6 P52701 K771I 771 K I 0.992 Pathogenic MSH6 P52701 K771L 771 K L 0.682 Pathogenic MSH6 P52701 K771M 771 K M 0.892 Pathogenic MSH6 P52701 K771N 771 K N 0.786 Pathogenic MSH6 P52701 K771P 771 K P 0.92 Pathogenic MSH6 P52701 K771Q 771 K Q 0.262 Neutral MSH6 P52701 K771R 771 K R 0.224 Neutral MSH6 P52701 K771S 771 K S 0.178 Neutral MSH6 P52701 K771T 771 K T 0.662 Pathogenic MSH6 P52701 K771V 771 K V 0.88 Pathogenic MSH6 P52701 K771W 771 K W 0.984 Pathogenic MSH6 P52701 K771Y 771 K Y 0.974 Pathogenic MSH6 P52701 R772A 772 R A 0.57 Pathogenic MSH6 P52701 R772C 772 R C 0.946 Pathogenic MSH6 P52701 R772D 772 R D 0.696 Pathogenic MSH6 P52701 R772E 772 R E 0.792 Pathogenic MSH6 P52701 R772F 772 R F 0.976 Pathogenic MSH6 P52701 R772G 772 R G 0.378 Neutral MSH6 P52701 R772H 772 R H 0.404 Neutral MSH6 P52701 R772I 772 R I 0.978 Pathogenic MSH6 P52701 R772K 772 R K 0.6 Pathogenic MSH6 P52701 R772L 772 R L 0.988 Pathogenic MSH6 P52701 R772M 772 R M 0.784 Pathogenic MSH6 P52701 R772N 772 R N 0.648 Pathogenic MSH6 P52701 R772P 772 R P 0.986 Pathogenic MSH6 P52701 R772Q 772 R Q 0.508 Pathogenic MSH6 P52701 R772S 772 R S 0.9 Pathogenic MSH6 P52701 R772T 772 R T 0.936 Pathogenic MSH6 P52701 R772V 772 R V 0.976 Pathogenic MSH6 P52701 R772W 772 R W 0.956 Pathogenic MSH6 P52701 R772Y 772 R Y 0.964 Pathogenic MSH6 P52701 L773A 773 L A 0.638 Pathogenic MSH6 P52701 L773C 773 L C 0.762 Pathogenic MSH6 P52701 L773D 773 L D 0.886 Pathogenic MSH6 P52701 L773E 773 L E 0.866 Pathogenic MSH6 P52701 L773F 773 L F 0.98 Pathogenic MSH6 P52701 L773G 773 L G 0.8 Pathogenic MSH6 P52701 L773H 773 L H 0.404 Neutral MSH6 P52701 L773I 773 L I 0.89 Pathogenic MSH6 P52701 L773K 773 L K 0.166 Neutral MSH6 P52701 L773M 773 L M 0.168 Neutral MSH6 P52701 L773N 773 L N 0.75 Pathogenic MSH6 P52701 L773P 773 L P 0.992 Pathogenic MSH6 P52701 L773Q 773 L Q 0.364 Neutral MSH6 P52701 L773R 773 L R 0.708 Pathogenic MSH6 P52701 L773S 773 L S 0.634 Pathogenic MSH6 P52701 L773T 773 L T 0.126 Neutral MSH6 P52701 L773V 773 L V 0.562 Pathogenic MSH6 P52701 L773W 773 L W 0.942 Pathogenic MSH6 P52701 L773Y 773 L Y 0.904 Pathogenic MSH6 P52701 L774A 774 L A 0.252 Neutral MSH6 P52701 L774C 774 L C 0.78 Pathogenic MSH6 P52701 L774D 774 L D 0.89 Pathogenic MSH6 P52701 L774E 774 L E 0.868 Pathogenic MSH6 P52701 L774F 774 L F 0.448 Neutral MSH6 P52701 L774G 774 L G 0.806 Pathogenic MSH6 P52701 L774H 774 L H 0.89 Pathogenic MSH6 P52701 L774I 774 L I 0.494 Neutral MSH6 P52701 L774K 774 L K 0.754 Pathogenic MSH6 P52701 L774M 774 L M 0.74 Pathogenic MSH6 P52701 L774N 774 L N 0.754 Pathogenic MSH6 P52701 L774P 774 L P 0.992 Pathogenic MSH6 P52701 L774Q 774 L Q 0.708 Pathogenic MSH6 P52701 L774R 774 L R 0.984 Pathogenic MSH6 P52701 L774S 774 L S 0.636 Pathogenic MSH6 P52701 L774T 774 L T 0.608 Pathogenic MSH6 P52701 L774V 774 L V 0.558 Pathogenic MSH6 P52701 L774W 774 L W 0.942 Pathogenic MSH6 P52701 L774Y 774 L Y 0.904 Pathogenic MSH6 P52701 K775A 775 K A 0.478 Neutral MSH6 P52701 K775C 775 K C 0.398 Neutral MSH6 P52701 K775D 775 K D 0.548 Pathogenic MSH6 P52701 K775E 775 K E 0.132 Neutral MSH6 P52701 K775F 775 K F 0.824 Pathogenic MSH6 P52701 K775G 775 K G 0.548 Pathogenic MSH6 P52701 K775H 775 K H 0.068 Neutral MSH6 P52701 K775I 775 K I 0.714 Pathogenic MSH6 P52701 K775L 775 K L 0.662 Pathogenic MSH6 P52701 K775M 775 K M 0.438 Neutral MSH6 P52701 K775N 775 K N 0.61 Pathogenic MSH6 P52701 K775P 775 K P 0.644 Pathogenic MSH6 P52701 K775Q 775 K Q 0.092 Neutral MSH6 P52701 K775R 775 K R 0.094 Neutral MSH6 P52701 K775S 775 K S 0.604 Pathogenic MSH6 P52701 K775T 775 K T 0.286 Neutral MSH6 P52701 K775V 775 K V 0.77 Pathogenic MSH6 P52701 K775W 775 K W 0.87 Pathogenic MSH6 P52701 K775Y 775 K Y 0.666 Pathogenic MSH6 P52701 Q776A 776 Q A 0.14 Neutral MSH6 P52701 Q776C 776 Q C 0.48 Neutral MSH6 P52701 Q776D 776 Q D 0.338 Neutral MSH6 P52701 Q776E 776 Q E 0.018 Neutral MSH6 P52701 Q776F 776 Q F 0.856 Pathogenic MSH6 P52701 Q776G 776 Q G 0.414 Neutral MSH6 P52701 Q776H 776 Q H 0.07 Neutral MSH6 P52701 Q776I 776 Q I 0.894 Pathogenic MSH6 P52701 Q776K 776 Q K 0.362 Neutral MSH6 P52701 Q776L 776 Q L 0.46 Neutral MSH6 P52701 Q776M 776 Q M 0.744 Pathogenic MSH6 P52701 Q776N 776 Q N 0.108 Neutral MSH6 P52701 Q776P 776 Q P 0.858 Pathogenic MSH6 P52701 Q776R 776 Q R 0.074 Neutral MSH6 P52701 Q776S 776 Q S 0.088 Neutral MSH6 P52701 Q776T 776 Q T 0.016 Neutral MSH6 P52701 Q776V 776 Q V 0.732 Pathogenic MSH6 P52701 Q776W 776 Q W 0.932 Pathogenic MSH6 P52701 Q776Y 776 Q Y 0.496 Neutral MSH6 P52701 W777A 777 W A 0.478 Neutral MSH6 P52701 W777C 777 W C 0.482 Neutral MSH6 P52701 W777D 777 W D 0.514 Pathogenic MSH6 P52701 W777E 777 W E 0.852 Pathogenic MSH6 P52701 W777F 777 W F 0.72 Pathogenic MSH6 P52701 W777G 777 W G 0.48 Neutral MSH6 P52701 W777H 777 W H 0.73 Pathogenic MSH6 P52701 W777I 777 W I 0.546 Pathogenic MSH6 P52701 W777K 777 W K 0.622 Pathogenic MSH6 P52701 W777L 777 W L 0.488 Neutral MSH6 P52701 W777M 777 W M 0.454 Neutral MSH6 P52701 W777N 777 W N 0.49 Neutral MSH6 P52701 W777P 777 W P 0.51 Pathogenic MSH6 P52701 W777Q 777 W Q 0.662 Pathogenic MSH6 P52701 W777R 777 W R 0.744 Pathogenic MSH6 P52701 W777S 777 W S 0.488 Neutral MSH6 P52701 W777T 777 W T 0.378 Neutral MSH6 P52701 W777V 777 W V 0.422 Neutral MSH6 P52701 W777Y 777 W Y 0.71 Pathogenic MSH6 P52701 L778A 778 L A 0.564 Pathogenic MSH6 P52701 L778C 778 L C 0.684 Pathogenic MSH6 P52701 L778D 778 L D 0.898 Pathogenic MSH6 P52701 L778E 778 L E 0.878 Pathogenic MSH6 P52701 L778F 778 L F 0.96 Pathogenic MSH6 P52701 L778G 778 L G 0.462 Neutral MSH6 P52701 L778H 778 L H 0.8 Pathogenic MSH6 P52701 L778I 778 L I 0.134 Neutral MSH6 P52701 L778K 778 L K 0.738 Pathogenic MSH6 P52701 L778M 778 L M 0.452 Neutral MSH6 P52701 L778N 778 L N 0.768 Pathogenic MSH6 P52701 L778P 778 L P 0.994 Pathogenic MSH6 P52701 L778Q 778 L Q 0.616 Pathogenic MSH6 P52701 L778R 778 L R 0.996 Pathogenic MSH6 P52701 L778S 778 L S 0.604 Pathogenic MSH6 P52701 L778T 778 L T 0.582 Pathogenic MSH6 P52701 L778V 778 L V 0.106 Neutral MSH6 P52701 L778W 778 L W 0.928 Pathogenic MSH6 P52701 L778Y 778 L Y 0.888 Pathogenic MSH6 P52701 C779A 779 C A 0.09 Neutral MSH6 P52701 C779D 779 C D 0.872 Pathogenic MSH6 P52701 C779E 779 C E 0.892 Pathogenic MSH6 P52701 C779F 779 C F 0.998 Pathogenic MSH6 P52701 C779G 779 C G 0.888 Pathogenic MSH6 P52701 C779H 779 C H 0.9 Pathogenic MSH6 P52701 C779I 779 C I 0.828 Pathogenic MSH6 P52701 C779K 779 C K 0.876 Pathogenic MSH6 P52701 C779L 779 C L 0.342 Neutral MSH6 P52701 C779M 779 C M 0.81 Pathogenic MSH6 P52701 C779N 779 C N 0.262 Neutral MSH6 P52701 C779P 779 C P 0.976 Pathogenic MSH6 P52701 C779Q 779 C Q 0.744 Pathogenic MSH6 P52701 C779R 779 C R 0.982 Pathogenic MSH6 P52701 C779S 779 C S 0.622 Pathogenic MSH6 P52701 C779T 779 C T 0.204 Neutral MSH6 P52701 C779V 779 C V 0.3 Neutral MSH6 P52701 C779W 779 C W 0.996 Pathogenic MSH6 P52701 C779Y 779 C Y 0.994 Pathogenic MSH6 P52701 R78A 78 R A 0.08 Neutral MSH6 P52701 R78C 78 R C 0.148 Neutral MSH6 P52701 R78D 78 R D 0.18 Neutral MSH6 P52701 R78E 78 R E 0.128 Neutral MSH6 P52701 R78F 78 R F 0.28 Neutral MSH6 P52701 R78G 78 R G 0.002 Neutral MSH6 P52701 R78H 78 R H 0.07 Neutral MSH6 P52701 R78I 78 R I 0.194 Neutral MSH6 P52701 R78K 78 R K 0.168 Neutral MSH6 P52701 R78L 78 R L 0.23 Neutral MSH6 P52701 R78M 78 R M 0.164 Neutral MSH6 P52701 R78N 78 R N 0.176 Neutral MSH6 P52701 R78P 78 R P 0.106 Neutral MSH6 P52701 R78Q 78 R Q 0.16 Neutral MSH6 P52701 R78S 78 R S 0.062 Neutral MSH6 P52701 R78T 78 R T 0.016 Neutral MSH6 P52701 R78V 78 R V 0.242 Neutral MSH6 P52701 R78W 78 R W 0.384 Neutral MSH6 P52701 R78Y 78 R Y 0.284 Neutral MSH6 P52701 A780C 780 A C 0.722 Pathogenic MSH6 P52701 A780D 780 A D 0.856 Pathogenic MSH6 P52701 A780E 780 A E 0.878 Pathogenic MSH6 P52701 A780F 780 A F 0.964 Pathogenic MSH6 P52701 A780G 780 A G 0.448 Neutral MSH6 P52701 A780H 780 A H 0.534 Pathogenic MSH6 P52701 A780I 780 A I 0.942 Pathogenic MSH6 P52701 A780K 780 A K 0.552 Pathogenic MSH6 P52701 A780L 780 A L 0.918 Pathogenic MSH6 P52701 A780M 780 A M 0.816 Pathogenic MSH6 P52701 A780N 780 A N 0.574 Pathogenic MSH6 P52701 A780P 780 A P 0.888 Pathogenic MSH6 P52701 A780Q 780 A Q 0.506 Pathogenic MSH6 P52701 A780R 780 A R 0.628 Pathogenic MSH6 P52701 A780S 780 A S 0.008 Neutral MSH6 P52701 A780T 780 A T 0.094 Neutral MSH6 P52701 A780V 780 A V 0.43 Neutral MSH6 P52701 A780W 780 A W 0.95 Pathogenic MSH6 P52701 A780Y 780 A Y 0.94 Pathogenic MSH6 P52701 P781A 781 P A 0.834 Pathogenic MSH6 P52701 P781C 781 P C 0.918 Pathogenic MSH6 P52701 P781D 781 P D 0.868 Pathogenic MSH6 P52701 P781E 781 P E 0.96 Pathogenic MSH6 P52701 P781F 781 P F 1 Pathogenic MSH6 P52701 P781G 781 P G 0.694 Pathogenic MSH6 P52701 P781H 781 P H 0.978 Pathogenic MSH6 P52701 P781I 781 P I 0.864 Pathogenic MSH6 P52701 P781K 781 P K 0.95 Pathogenic MSH6 P52701 P781L 781 P L 0.998 Pathogenic MSH6 P52701 P781M 781 P M 0.96 Pathogenic MSH6 P52701 P781N 781 P N 0.788 Pathogenic MSH6 P52701 P781Q 781 P Q 0.882 Pathogenic MSH6 P52701 P781R 781 P R 0.986 Pathogenic MSH6 P52701 P781S 781 P S 0.346 Neutral MSH6 P52701 P781T 781 P T 0.736 Pathogenic MSH6 P52701 P781V 781 P V 0.844 Pathogenic MSH6 P52701 P781W 781 P W 0.932 Pathogenic MSH6 P52701 P781Y 781 P Y 0.926 Pathogenic MSH6 P52701 L782A 782 L A 0.548 Pathogenic MSH6 P52701 L782C 782 L C 0.292 Neutral MSH6 P52701 L782D 782 L D 0.864 Pathogenic MSH6 P52701 L782E 782 L E 0.85 Pathogenic MSH6 P52701 L782F 782 L F 0.968 Pathogenic MSH6 P52701 L782G 782 L G 0.774 Pathogenic MSH6 P52701 L782H 782 L H 0.804 Pathogenic MSH6 P52701 L782I 782 L I 0.458 Neutral MSH6 P52701 L782K 782 L K 0.72 Pathogenic MSH6 P52701 L782M 782 L M 0.726 Pathogenic MSH6 P52701 L782N 782 L N 0.732 Pathogenic MSH6 P52701 L782P 782 L P 0.292 Neutral MSH6 P52701 L782Q 782 L Q 0.604 Pathogenic MSH6 P52701 L782R 782 L R 0.974 Pathogenic MSH6 P52701 L782S 782 L S 0.14 Neutral MSH6 P52701 L782T 782 L T 0.13 Neutral MSH6 P52701 L782V 782 L V 0.108 Neutral MSH6 P52701 L782W 782 L W 0.936 Pathogenic MSH6 P52701 L782Y 782 L Y 0.9 Pathogenic MSH6 P52701 C783A 783 C A 0.046 Neutral MSH6 P52701 C783D 783 C D 0.606 Pathogenic MSH6 P52701 C783E 783 C E 0.612 Pathogenic MSH6 P52701 C783F 783 C F 0.578 Pathogenic MSH6 P52701 C783G 783 C G 0.524 Pathogenic MSH6 P52701 C783H 783 C H 0.74 Pathogenic MSH6 P52701 C783I 783 C I 0.804 Pathogenic MSH6 P52701 C783K 783 C K 0.648 Pathogenic MSH6 P52701 C783L 783 C L 0.78 Pathogenic MSH6 P52701 C783M 783 C M 0.086 Neutral MSH6 P52701 C783N 783 C N 0.142 Neutral MSH6 P52701 C783P 783 C P 0.888 Pathogenic MSH6 P52701 C783Q 783 C Q 0.148 Neutral MSH6 P52701 C783R 783 C R 0.586 Pathogenic MSH6 P52701 C783S 783 C S 0.44 Neutral MSH6 P52701 C783T 783 C T 0.014 Neutral MSH6 P52701 C783V 783 C V 0.064 Neutral MSH6 P52701 C783W 783 C W 0.946 Pathogenic MSH6 P52701 C783Y 783 C Y 0.562 Pathogenic MSH6 P52701 N784A 784 N A 0.492 Neutral MSH6 P52701 N784C 784 N C 0.584 Pathogenic MSH6 P52701 N784D 784 N D 0.052 Neutral MSH6 P52701 N784E 784 N E 0.066 Neutral MSH6 P52701 N784F 784 N F 0.912 Pathogenic MSH6 P52701 N784G 784 N G 0.316 Neutral MSH6 P52701 N784H 784 N H 0.072 Neutral MSH6 P52701 N784I 784 N I 0.862 Pathogenic MSH6 P52701 N784K 784 N K 0.11 Neutral MSH6 P52701 N784L 784 N L 0.866 Pathogenic MSH6 P52701 N784M 784 N M 0.83 Pathogenic MSH6 P52701 N784P 784 N P 0.754 Pathogenic MSH6 P52701 N784Q 784 N Q 0.06 Neutral MSH6 P52701 N784R 784 N R 0.454 Neutral MSH6 P52701 N784S 784 N S 0.038 Neutral MSH6 P52701 N784T 784 N T 0.58 Pathogenic MSH6 P52701 N784V 784 N V 0.452 Neutral MSH6 P52701 N784W 784 N W 0.954 Pathogenic MSH6 P52701 N784Y 784 N Y 0.946 Pathogenic MSH6 P52701 H785A 785 H A 0.094 Neutral MSH6 P52701 H785C 785 H C 0.214 Neutral MSH6 P52701 H785D 785 H D 0.224 Neutral MSH6 P52701 H785E 785 H E 0.266 Neutral MSH6 P52701 H785F 785 H F 0.69 Pathogenic MSH6 P52701 H785G 785 H G 0.288 Neutral MSH6 P52701 H785I 785 H I 0.06 Neutral MSH6 P52701 H785K 785 H K 0.016 Neutral MSH6 P52701 H785L 785 H L 0.048 Neutral MSH6 P52701 H785M 785 H M 0.344 Neutral MSH6 P52701 H785N 785 H N 0.21 Neutral MSH6 P52701 H785P 785 H P 0.102 Neutral MSH6 P52701 H785Q 785 H Q 0.178 Neutral MSH6 P52701 H785R 785 H R 0.006 Neutral MSH6 P52701 H785S 785 H S 0.028 Neutral MSH6 P52701 H785T 785 H T 0.014 Neutral MSH6 P52701 H785V 785 H V 0.048 Neutral MSH6 P52701 H785W 785 H W 0.898 Pathogenic MSH6 P52701 H785Y 785 H Y 0.708 Pathogenic MSH6 P52701 Y786A 786 Y A 0.054 Neutral MSH6 P52701 Y786C 786 Y C 0.152 Neutral MSH6 P52701 Y786D 786 Y D 0.042 Neutral MSH6 P52701 Y786E 786 Y E 0.038 Neutral MSH6 P52701 Y786F 786 Y F 0.01 Neutral MSH6 P52701 Y786G 786 Y G 0.108 Neutral MSH6 P52701 Y786H 786 Y H 0.006 Neutral MSH6 P52701 Y786I 786 Y I 0.126 Neutral MSH6 P52701 Y786K 786 Y K 0.024 Neutral MSH6 P52701 Y786L 786 Y L 0.032 Neutral MSH6 P52701 Y786M 786 Y M 0.134 Neutral MSH6 P52701 Y786N 786 Y N 0.078 Neutral MSH6 P52701 Y786P 786 Y P 0.098 Neutral MSH6 P52701 Y786Q 786 Y Q 0.07 Neutral MSH6 P52701 Y786R 786 Y R 0.042 Neutral MSH6 P52701 Y786S 786 Y S 0.106 Neutral MSH6 P52701 Y786T 786 Y T 0.062 Neutral MSH6 P52701 Y786V 786 Y V 0.016 Neutral MSH6 P52701 Y786W 786 Y W 0.112 Neutral MSH6 P52701 A787C 787 A C 0.628 Pathogenic MSH6 P52701 A787D 787 A D 0.604 Pathogenic MSH6 P52701 A787E 787 A E 0.534 Pathogenic MSH6 P52701 A787F 787 A F 0.91 Pathogenic MSH6 P52701 A787G 787 A G 0.104 Neutral MSH6 P52701 A787H 787 A H 0.786 Pathogenic MSH6 P52701 A787I 787 A I 0.578 Pathogenic MSH6 P52701 A787K 787 A K 0.502 Pathogenic MSH6 P52701 A787L 787 A L 0.528 Pathogenic MSH6 P52701 A787M 787 A M 0.768 Pathogenic MSH6 P52701 A787N 787 A N 0.724 Pathogenic MSH6 P52701 A787P 787 A P 0.138 Neutral MSH6 P52701 A787Q 787 A Q 0.596 Pathogenic MSH6 P52701 A787R 787 A R 0.554 Pathogenic MSH6 P52701 A787S 787 A S 0.044 Neutral MSH6 P52701 A787T 787 A T 0.256 Neutral MSH6 P52701 A787V 787 A V 0.096 Neutral MSH6 P52701 A787W 787 A W 0.904 Pathogenic MSH6 P52701 A787Y 787 A Y 0.896 Pathogenic MSH6 P52701 I788A 788 I A 0.638 Pathogenic MSH6 P52701 I788C 788 I C 0.718 Pathogenic MSH6 P52701 I788D 788 I D 0.786 Pathogenic MSH6 P52701 I788E 788 I E 0.786 Pathogenic MSH6 P52701 I788F 788 I F 0.796 Pathogenic MSH6 P52701 I788G 788 I G 0.864 Pathogenic MSH6 P52701 I788H 788 I H 0.894 Pathogenic MSH6 P52701 I788K 788 I K 0.824 Pathogenic MSH6 P52701 I788L 788 I L 0.052 Neutral MSH6 P52701 I788M 788 I M 0.638 Pathogenic MSH6 P52701 I788N 788 I N 0.806 Pathogenic MSH6 P52701 I788P 788 I P 0.904 Pathogenic MSH6 P52701 I788Q 788 I Q 0.814 Pathogenic MSH6 P52701 I788R 788 I R 0.892 Pathogenic MSH6 P52701 I788S 788 I S 0.69 Pathogenic MSH6 P52701 I788T 788 I T 0.3 Neutral MSH6 P52701 I788V 788 I V 0.232 Neutral MSH6 P52701 I788W 788 I W 0.862 Pathogenic MSH6 P52701 I788Y 788 I Y 0.838 Pathogenic MSH6 P52701 N789A 789 N A 0.402 Neutral MSH6 P52701 N789C 789 N C 0.372 Neutral MSH6 P52701 N789D 789 N D 0.066 Neutral MSH6 P52701 N789E 789 N E 0.068 Neutral MSH6 P52701 N789F 789 N F 0.908 Pathogenic MSH6 P52701 N789G 789 N G 0.352 Neutral MSH6 P52701 N789H 789 N H 0.77 Pathogenic MSH6 P52701 N789I 789 N I 0.356 Neutral MSH6 P52701 N789K 789 N K 0.102 Neutral MSH6 P52701 N789L 789 N L 0.18 Neutral MSH6 P52701 N789M 789 N M 0.824 Pathogenic MSH6 P52701 N789P 789 N P 0.814 Pathogenic MSH6 P52701 N789Q 789 N Q 0.08 Neutral MSH6 P52701 N789R 789 N R 0.45 Neutral MSH6 P52701 N789S 789 N S 0.072 Neutral MSH6 P52701 N789T 789 N T 0.082 Neutral MSH6 P52701 N789V 789 N V 0.122 Neutral MSH6 P52701 N789W 789 N W 0.954 Pathogenic MSH6 P52701 N789Y 789 N Y 0.958 Pathogenic MSH6 P52701 S79A 79 S A 0.052 Neutral MSH6 P52701 S79C 79 S C 0.032 Neutral MSH6 P52701 S79D 79 S D 0.044 Neutral MSH6 P52701 S79E 79 S E 0.148 Neutral MSH6 P52701 S79F 79 S F 0.276 Neutral MSH6 P52701 S79G 79 S G 0 Neutral MSH6 P52701 S79H 79 S H 0.238 Neutral MSH6 P52701 S79I 79 S I 0.026 Neutral MSH6 P52701 S79K 79 S K 0.14 Neutral MSH6 P52701 S79L 79 S L 0.042 Neutral MSH6 P52701 S79M 79 S M 0.332 Neutral MSH6 P52701 S79N 79 S N 0.012 Neutral MSH6 P52701 S79P 79 S P 0.062 Neutral MSH6 P52701 S79Q 79 S Q 0.132 Neutral MSH6 P52701 S79R 79 S R 0.248 Neutral MSH6 P52701 S79T 79 S T 0.176 Neutral MSH6 P52701 S79V 79 S V 0.248 Neutral MSH6 P52701 S79W 79 S W 0.472 Neutral MSH6 P52701 S79Y 79 S Y 0.448 Neutral MSH6 P52701 D790A 790 D A 0.102 Neutral MSH6 P52701 D790C 790 D C 0.728 Pathogenic MSH6 P52701 D790E 790 D E 0.036 Neutral MSH6 P52701 D790F 790 D F 0.928 Pathogenic MSH6 P52701 D790G 790 D G 0.094 Neutral MSH6 P52701 D790H 790 D H 0.544 Pathogenic MSH6 P52701 D790I 790 D I 0.886 Pathogenic MSH6 P52701 D790K 790 D K 0.094 Neutral MSH6 P52701 D790L 790 D L 0.122 Neutral MSH6 P52701 D790M 790 D M 0.798 Pathogenic MSH6 P52701 D790N 790 D N 0.074 Neutral MSH6 P52701 D790P 790 D P 0.802 Pathogenic MSH6 P52701 D790Q 790 D Q 0.014 Neutral MSH6 P52701 D790R 790 D R 0.47 Neutral MSH6 P52701 D790S 790 D S 0.024 Neutral MSH6 P52701 D790T 790 D T 0.574 Pathogenic MSH6 P52701 D790V 790 D V 0.822 Pathogenic MSH6 P52701 D790W 790 D W 0.97 Pathogenic MSH6 P52701 D790Y 790 D Y 0.964 Pathogenic MSH6 P52701 R791A 791 R A 0.57 Pathogenic MSH6 P52701 R791C 791 R C 0.946 Pathogenic MSH6 P52701 R791D 791 R D 0.696 Pathogenic MSH6 P52701 R791E 791 R E 0.792 Pathogenic MSH6 P52701 R791F 791 R F 0.976 Pathogenic MSH6 P52701 R791G 791 R G 0.378 Neutral MSH6 P52701 R791H 791 R H 0.404 Neutral MSH6 P52701 R791I 791 R I 0.978 Pathogenic MSH6 P52701 R791K 791 R K 0.764 Pathogenic MSH6 P52701 R791L 791 R L 0.988 Pathogenic MSH6 P52701 R791M 791 R M 0.784 Pathogenic MSH6 P52701 R791N 791 R N 0.648 Pathogenic MSH6 P52701 R791P 791 R P 0.986 Pathogenic MSH6 P52701 R791Q 791 R Q 0.508 Pathogenic MSH6 P52701 R791S 791 R S 0.9 Pathogenic MSH6 P52701 R791T 791 R T 0.936 Pathogenic MSH6 P52701 R791V 791 R V 0.976 Pathogenic MSH6 P52701 R791W 791 R W 0.956 Pathogenic MSH6 P52701 R791Y 791 R Y 0.834 Pathogenic MSH6 P52701 L792A 792 L A 0.108 Neutral MSH6 P52701 L792C 792 L C 0.678 Pathogenic MSH6 P52701 L792D 792 L D 0.524 Pathogenic MSH6 P52701 L792E 792 L E 0.876 Pathogenic MSH6 P52701 L792F 792 L F 0.54 Pathogenic MSH6 P52701 L792G 792 L G 0.798 Pathogenic MSH6 P52701 L792H 792 L H 0.796 Pathogenic MSH6 P52701 L792I 792 L I 0.82 Pathogenic MSH6 P52701 L792K 792 L K 0.744 Pathogenic MSH6 P52701 L792M 792 L M 0.75 Pathogenic MSH6 P52701 L792N 792 L N 0.762 Pathogenic MSH6 P52701 L792P 792 L P 0.998 Pathogenic MSH6 P52701 L792Q 792 L Q 0.1 Neutral MSH6 P52701 L792R 792 L R 0.988 Pathogenic MSH6 P52701 L792S 792 L S 0.608 Pathogenic MSH6 P52701 L792T 792 L T 0.582 Pathogenic MSH6 P52701 L792V 792 L V 0.572 Pathogenic MSH6 P52701 L792W 792 L W 0.822 Pathogenic MSH6 P52701 L792Y 792 L Y 0.83 Pathogenic MSH6 P52701 D793A 793 D A 0.322 Neutral MSH6 P52701 D793C 793 D C 0.824 Pathogenic MSH6 P52701 D793E 793 D E 0.204 Neutral MSH6 P52701 D793F 793 D F 0.97 Pathogenic MSH6 P52701 D793G 793 D G 0.156 Neutral MSH6 P52701 D793H 793 D H 0.47 Neutral MSH6 P52701 D793I 793 D I 0.958 Pathogenic MSH6 P52701 D793K 793 D K 0.354 Neutral MSH6 P52701 D793L 793 D L 0.95 Pathogenic MSH6 P52701 D793M 793 D M 0.902 Pathogenic MSH6 P52701 D793N 793 D N 0.064 Neutral MSH6 P52701 D793P 793 D P 0.862 Pathogenic MSH6 P52701 D793Q 793 D Q 0.152 Neutral MSH6 P52701 D793R 793 D R 0.568 Pathogenic MSH6 P52701 D793S 793 D S 0.108 Neutral MSH6 P52701 D793T 793 D T 0.712 Pathogenic MSH6 P52701 D793V 793 D V 0.528 Pathogenic MSH6 P52701 D793W 793 D W 0.976 Pathogenic MSH6 P52701 D793Y 793 D Y 0.97 Pathogenic MSH6 P52701 A794C 794 A C 0.564 Pathogenic MSH6 P52701 A794D 794 A D 0.896 Pathogenic MSH6 P52701 A794E 794 A E 0.842 Pathogenic MSH6 P52701 A794F 794 A F 0.94 Pathogenic MSH6 P52701 A794G 794 A G 0.708 Pathogenic MSH6 P52701 A794H 794 A H 0.834 Pathogenic MSH6 P52701 A794I 794 A I 0.94 Pathogenic MSH6 P52701 A794K 794 A K 0.908 Pathogenic MSH6 P52701 A794L 794 A L 0.952 Pathogenic MSH6 P52701 A794M 794 A M 0.82 Pathogenic MSH6 P52701 A794N 794 A N 0.828 Pathogenic MSH6 P52701 A794P 794 A P 0.95 Pathogenic MSH6 P52701 A794Q 794 A Q 0.782 Pathogenic MSH6 P52701 A794R 794 A R 0.942 Pathogenic MSH6 P52701 A794S 794 A S 0.226 Neutral MSH6 P52701 A794T 794 A T 0.676 Pathogenic MSH6 P52701 A794V 794 A V 0.468 Neutral MSH6 P52701 A794W 794 A W 0.95 Pathogenic MSH6 P52701 A794Y 794 A Y 0.946 Pathogenic MSH6 P52701 I795A 795 I A 0.216 Neutral MSH6 P52701 I795C 795 I C 0.592 Pathogenic MSH6 P52701 I795D 795 I D 0.734 Pathogenic MSH6 P52701 I795E 795 I E 0.744 Pathogenic MSH6 P52701 I795F 795 I F 0.96 Pathogenic MSH6 P52701 I795G 795 I G 0.79 Pathogenic MSH6 P52701 I795H 795 I H 0.838 Pathogenic MSH6 P52701 I795K 795 I K 0.838 Pathogenic MSH6 P52701 I795L 795 I L 0.12 Neutral MSH6 P52701 I795M 795 I M 0.19 Neutral MSH6 P52701 I795N 795 I N 0.76 Pathogenic MSH6 P52701 I795P 795 I P 0.92 Pathogenic MSH6 P52701 I795Q 795 I Q 0.774 Pathogenic MSH6 P52701 I795R 795 I R 0.87 Pathogenic MSH6 P52701 I795S 795 I S 0.604 Pathogenic MSH6 P52701 I795T 795 I T 0.324 Neutral MSH6 P52701 I795V 795 I V 0.248 Neutral MSH6 P52701 I795W 795 I W 0.986 Pathogenic MSH6 P52701 I795Y 795 I Y 0.976 Pathogenic MSH6 P52701 E796A 796 E A 0.196 Neutral MSH6 P52701 E796C 796 E C 0.122 Neutral MSH6 P52701 E796D 796 E D 0.004 Neutral MSH6 P52701 E796F 796 E F 0.426 Neutral MSH6 P52701 E796G 796 E G 0 Neutral MSH6 P52701 E796H 796 E H 0.246 Neutral MSH6 P52701 E796I 796 E I 0.498 Neutral MSH6 P52701 E796K 796 E K 0.004 Neutral MSH6 P52701 E796L 796 E L 0.458 Neutral MSH6 P52701 E796M 796 E M 0.282 Neutral MSH6 P52701 E796N 796 E N 0.09 Neutral MSH6 P52701 E796P 796 E P 0.472 Neutral MSH6 P52701 E796Q 796 E Q 0 Neutral MSH6 P52701 E796R 796 E R 0.034 Neutral MSH6 P52701 E796S 796 E S 0.024 Neutral MSH6 P52701 E796T 796 E T 0.01 Neutral MSH6 P52701 E796V 796 E V 0.404 Neutral MSH6 P52701 E796W 796 E W 0.696 Pathogenic MSH6 P52701 E796Y 796 E Y 0.58 Pathogenic MSH6 P52701 D797A 797 D A 0.144 Neutral MSH6 P52701 D797C 797 D C 0.328 Neutral MSH6 P52701 D797E 797 D E 0.012 Neutral MSH6 P52701 D797F 797 D F 0.626 Pathogenic MSH6 P52701 D797G 797 D G 0.2 Neutral MSH6 P52701 D797H 797 D H 0.152 Neutral MSH6 P52701 D797I 797 D I 0.452 Neutral MSH6 P52701 D797K 797 D K 0.31 Neutral MSH6 P52701 D797L 797 D L 0.436 Neutral MSH6 P52701 D797M 797 D M 0.338 Neutral MSH6 P52701 D797N 797 D N 0.052 Neutral MSH6 P52701 D797P 797 D P 0.458 Neutral MSH6 P52701 D797Q 797 D Q 0.18 Neutral MSH6 P52701 D797R 797 D R 0.372 Neutral MSH6 P52701 D797S 797 D S 0.11 Neutral MSH6 P52701 D797T 797 D T 0.274 Neutral MSH6 P52701 D797V 797 D V 0.288 Neutral MSH6 P52701 D797W 797 D W 0.746 Pathogenic MSH6 P52701 D797Y 797 D Y 0.76 Pathogenic MSH6 P52701 L798A 798 L A 0.262 Neutral MSH6 P52701 L798C 798 L C 0.29 Neutral MSH6 P52701 L798D 798 L D 0.57 Pathogenic MSH6 P52701 L798E 798 L E 0.532 Pathogenic MSH6 P52701 L798F 798 L F 0.76 Pathogenic MSH6 P52701 L798G 798 L G 0.538 Pathogenic MSH6 P52701 L798H 798 L H 0.288 Neutral MSH6 P52701 L798I 798 L I 0.056 Neutral MSH6 P52701 L798K 798 L K 0.428 Neutral MSH6 P52701 L798M 798 L M 0.428 Neutral MSH6 P52701 L798N 798 L N 0.548 Pathogenic MSH6 P52701 L798P 798 L P 0.828 Pathogenic MSH6 P52701 L798Q 798 L Q 0.276 Neutral MSH6 P52701 L798R 798 L R 0.804 Pathogenic MSH6 P52701 L798S 798 L S 0.412 Neutral MSH6 P52701 L798T 798 L T 0.372 Neutral MSH6 P52701 L798V 798 L V 0.412 Neutral MSH6 P52701 L798W 798 L W 0.818 Pathogenic MSH6 P52701 L798Y 798 L Y 0.812 Pathogenic MSH6 P52701 M799A 799 M A 0.098 Neutral MSH6 P52701 M799C 799 M C 0.074 Neutral MSH6 P52701 M799D 799 M D 0.234 Neutral MSH6 P52701 M799E 799 M E 0.11 Neutral MSH6 P52701 M799F 799 M F 0.182 Neutral MSH6 P52701 M799G 799 M G 0.18 Neutral MSH6 P52701 M799H 799 M H 0.05 Neutral MSH6 P52701 M799I 799 M I 0.018 Neutral MSH6 P52701 M799K 799 M K 0.102 Neutral MSH6 P52701 M799L 799 M L 0.012 Neutral MSH6 P52701 M799N 799 M N 0.26 Neutral MSH6 P52701 M799P 799 M P 0.414 Neutral MSH6 P52701 M799Q 799 M Q 0.104 Neutral MSH6 P52701 M799R 799 M R 0.062 Neutral MSH6 P52701 M799S 799 M S 0.244 Neutral MSH6 P52701 M799T 799 M T 0.212 Neutral MSH6 P52701 M799V 799 M V 0.026 Neutral MSH6 P52701 M799W 799 M W 0.674 Pathogenic MSH6 P52701 M799Y 799 M Y 0.582 Pathogenic MSH6 P52701 Y8A 8 Y A 0.082 Neutral MSH6 P52701 Y8C 8 Y C 0.112 Neutral MSH6 P52701 Y8D 8 Y D 0.18 Neutral MSH6 P52701 Y8E 8 Y E 0.18 Neutral MSH6 P52701 Y8F 8 Y F 0.01 Neutral MSH6 P52701 Y8G 8 Y G 0.122 Neutral MSH6 P52701 Y8H 8 Y H 0.054 Neutral MSH6 P52701 Y8I 8 Y I 0.094 Neutral MSH6 P52701 Y8K 8 Y K 0.168 Neutral MSH6 P52701 Y8L 8 Y L 0.04 Neutral MSH6 P52701 Y8M 8 Y M 0.074 Neutral MSH6 P52701 Y8N 8 Y N 0.116 Neutral MSH6 P52701 Y8P 8 Y P 0.072 Neutral MSH6 P52701 Y8Q 8 Y Q 0.064 Neutral MSH6 P52701 Y8R 8 Y R 0.156 Neutral MSH6 P52701 Y8S 8 Y S 0.122 Neutral MSH6 P52701 Y8T 8 Y T 0.112 Neutral MSH6 P52701 Y8V 8 Y V 0.162 Neutral MSH6 P52701 Y8W 8 Y W 0.048 Neutral MSH6 P52701 V80A 80 V A 0 Neutral MSH6 P52701 V80C 80 V C 0.058 Neutral MSH6 P52701 V80D 80 V D 0.126 Neutral MSH6 P52701 V80E 80 V E 0.158 Neutral MSH6 P52701 V80F 80 V F 0.172 Neutral MSH6 P52701 V80G 80 V G 0.178 Neutral MSH6 P52701 V80H 80 V H 0.112 Neutral MSH6 P52701 V80I 80 V I 0.038 Neutral MSH6 P52701 V80K 80 V K 0.158 Neutral MSH6 P52701 V80L 80 V L 0.018 Neutral MSH6 P52701 V80M 80 V M 0.076 Neutral MSH6 P52701 V80N 80 V N 0.138 Neutral MSH6 P52701 V80P 80 V P 0.036 Neutral MSH6 P52701 V80Q 80 V Q 0.158 Neutral MSH6 P52701 V80R 80 V R 0.274 Neutral MSH6 P52701 V80S 80 V S 0.01 Neutral MSH6 P52701 V80T 80 V T 0.008 Neutral MSH6 P52701 V80W 80 V W 0.344 Neutral MSH6 P52701 V80Y 80 V Y 0.256 Neutral MSH6 P52701 V800A 800 V A 0 Neutral MSH6 P52701 V800C 800 V C 0.058 Neutral MSH6 P52701 V800D 800 V D 0.028 Neutral MSH6 P52701 V800E 800 V E 0.044 Neutral MSH6 P52701 V800F 800 V F 0.142 Neutral MSH6 P52701 V800G 800 V G 0.038 Neutral MSH6 P52701 V800H 800 V H 0.112 Neutral MSH6 P52701 V800I 800 V I 0.06 Neutral MSH6 P52701 V800K 800 V K 0.062 Neutral MSH6 P52701 V800L 800 V L 0.018 Neutral MSH6 P52701 V800M 800 V M 0.076 Neutral MSH6 P52701 V800N 800 V N 0.05 Neutral MSH6 P52701 V800P 800 V P 0.19 Neutral MSH6 P52701 V800Q 800 V Q 0.158 Neutral MSH6 P52701 V800R 800 V R 0.21 Neutral MSH6 P52701 V800S 800 V S 0.01 Neutral MSH6 P52701 V800T 800 V T 0.094 Neutral MSH6 P52701 V800W 800 V W 0.344 Neutral MSH6 P52701 V800Y 800 V Y 0.256 Neutral MSH6 P52701 V801A 801 V A 0.036 Neutral MSH6 P52701 V801C 801 V C 0.334 Neutral MSH6 P52701 V801D 801 V D 0.27 Neutral MSH6 P52701 V801E 801 V E 0.112 Neutral MSH6 P52701 V801F 801 V F 0.478 Neutral MSH6 P52701 V801G 801 V G 0.612 Pathogenic MSH6 P52701 V801H 801 V H 0.138 Neutral MSH6 P52701 V801I 801 V I 0.028 Neutral MSH6 P52701 V801K 801 V K 0.378 Neutral MSH6 P52701 V801L 801 V L 0.038 Neutral MSH6 P52701 V801M 801 V M 0.056 Neutral MSH6 P52701 V801N 801 V N 0.102 Neutral MSH6 P52701 V801P 801 V P 0.714 Pathogenic MSH6 P52701 V801Q 801 V Q 0.122 Neutral MSH6 P52701 V801R 801 V R 0.468 Neutral MSH6 P52701 V801S 801 V S 0.07 Neutral MSH6 P52701 V801T 801 V T 0.042 Neutral MSH6 P52701 V801W 801 V W 0.722 Pathogenic MSH6 P52701 V801Y 801 V Y 0.604 Pathogenic MSH6 P52701 P802A 802 P A 0.098 Neutral MSH6 P52701 P802C 802 P C 0.514 Pathogenic MSH6 P52701 P802D 802 P D 0.092 Neutral MSH6 P52701 P802E 802 P E 0.128 Neutral MSH6 P52701 P802F 802 P F 0.656 Pathogenic MSH6 P52701 P802G 802 P G 0.276 Neutral MSH6 P52701 P802H 802 P H 0.744 Pathogenic MSH6 P52701 P802I 802 P I 0.178 Neutral MSH6 P52701 P802K 802 P K 0.118 Neutral MSH6 P52701 P802L 802 P L 0.104 Neutral MSH6 P52701 P802M 802 P M 0.196 Neutral MSH6 P52701 P802N 802 P N 0.08 Neutral MSH6 P52701 P802Q 802 P Q 0.124 Neutral MSH6 P52701 P802R 802 P R 0.464 Neutral MSH6 P52701 P802S 802 P S 0.056 Neutral MSH6 P52701 P802T 802 P T 0.066 Neutral MSH6 P52701 P802V 802 P V 0.1 Neutral MSH6 P52701 P802W 802 P W 0.804 Pathogenic MSH6 P52701 P802Y 802 P Y 0.778 Pathogenic MSH6 P52701 D803A 803 D A 0.076 Neutral MSH6 P52701 D803C 803 D C 0.092 Neutral MSH6 P52701 D803E 803 D E 0.04 Neutral MSH6 P52701 D803F 803 D F 0.362 Neutral MSH6 P52701 D803G 803 D G 0.064 Neutral MSH6 P52701 D803H 803 D H 0.068 Neutral MSH6 P52701 D803I 803 D I 0.804 Pathogenic MSH6 P52701 D803K 803 D K 0.368 Neutral MSH6 P52701 D803L 803 D L 0.77 Pathogenic MSH6 P52701 D803M 803 D M 0.118 Neutral MSH6 P52701 D803N 803 D N 0.03 Neutral MSH6 P52701 D803P 803 D P 0.398 Neutral MSH6 P52701 D803Q 803 D Q 0.044 Neutral MSH6 P52701 D803R 803 D R 0.402 Neutral MSH6 P52701 D803S 803 D S 0.034 Neutral MSH6 P52701 D803T 803 D T 0.07 Neutral MSH6 P52701 D803V 803 D V 0.256 Neutral MSH6 P52701 D803W 803 D W 0.9 Pathogenic MSH6 P52701 D803Y 803 D Y 0.594 Pathogenic MSH6 P52701 K804A 804 K A 0.038 Neutral MSH6 P52701 K804C 804 K C 0.094 Neutral MSH6 P52701 K804D 804 K D 0.132 Neutral MSH6 P52701 K804E 804 K E 0.006 Neutral MSH6 P52701 K804F 804 K F 0.048 Neutral MSH6 P52701 K804G 804 K G 0.226 Neutral MSH6 P52701 K804H 804 K H 0.12 Neutral MSH6 P52701 K804I 804 K I 0.072 Neutral MSH6 P52701 K804L 804 K L 0.056 Neutral MSH6 P52701 K804M 804 K M 0.168 Neutral MSH6 P52701 K804N 804 K N 0.012 Neutral MSH6 P52701 K804P 804 K P 0.488 Neutral MSH6 P52701 K804Q 804 K Q 0.018 Neutral MSH6 P52701 K804R 804 K R 0.008 Neutral MSH6 P52701 K804S 804 K S 0.026 Neutral MSH6 P52701 K804T 804 K T 0.03 Neutral MSH6 P52701 K804V 804 K V 0.05 Neutral MSH6 P52701 K804W 804 K W 0.76 Pathogenic MSH6 P52701 K804Y 804 K Y 0.65 Pathogenic MSH6 P52701 I805A 805 I A 0.068 Neutral MSH6 P52701 I805C 805 I C 0.232 Neutral MSH6 P52701 I805D 805 I D 0.576 Pathogenic MSH6 P52701 I805E 805 I E 0.558 Pathogenic MSH6 P52701 I805F 805 I F 0.164 Neutral MSH6 P52701 I805G 805 I G 0.56 Pathogenic MSH6 P52701 I805H 805 I H 0.44 Neutral MSH6 P52701 I805K 805 I K 0.57 Pathogenic MSH6 P52701 I805L 805 I L 0.02 Neutral MSH6 P52701 I805M 805 I M 0.054 Neutral MSH6 P52701 I805N 805 I N 0.66 Pathogenic MSH6 P52701 I805P 805 I P 0.704 Pathogenic MSH6 P52701 I805Q 805 I Q 0.596 Pathogenic MSH6 P52701 I805R 805 I R 0.824 Pathogenic MSH6 P52701 I805S 805 I S 0.53 Pathogenic MSH6 P52701 I805T 805 I T 0.042 Neutral MSH6 P52701 I805V 805 I V 0.012 Neutral MSH6 P52701 I805W 805 I W 0.898 Pathogenic MSH6 P52701 I805Y 805 I Y 0.876 Pathogenic MSH6 P52701 S806A 806 S A 0.012 Neutral MSH6 P52701 S806C 806 S C 0.108 Neutral MSH6 P52701 S806D 806 S D 0.01 Neutral MSH6 P52701 S806E 806 S E 0.298 Neutral MSH6 P52701 S806F 806 S F 0.492 Neutral MSH6 P52701 S806G 806 S G 0.008 Neutral MSH6 P52701 S806H 806 S H 0.516 Pathogenic MSH6 P52701 S806I 806 S I 0.256 Neutral MSH6 P52701 S806K 806 S K 0.316 Neutral MSH6 P52701 S806L 806 S L 0.056 Neutral MSH6 P52701 S806M 806 S M 0.696 Pathogenic MSH6 P52701 S806N 806 S N 0.02 Neutral MSH6 P52701 S806P 806 S P 0.17 Neutral MSH6 P52701 S806Q 806 S Q 0.332 Neutral MSH6 P52701 S806R 806 S R 0.32 Neutral MSH6 P52701 S806T 806 S T 0.018 Neutral MSH6 P52701 S806V 806 S V 0.466 Neutral MSH6 P52701 S806W 806 S W 0.62 Pathogenic MSH6 P52701 S806Y 806 S Y 0.78 Pathogenic MSH6 P52701 E807A 807 E A 0.246 Neutral MSH6 P52701 E807C 807 E C 0.462 Neutral MSH6 P52701 E807D 807 E D 0.04 Neutral MSH6 P52701 E807F 807 E F 0.818 Pathogenic MSH6 P52701 E807G 807 E G 0.04 Neutral MSH6 P52701 E807H 807 E H 0.59 Pathogenic MSH6 P52701 E807I 807 E I 0.866 Pathogenic MSH6 P52701 E807K 807 E K 0.052 Neutral MSH6 P52701 E807L 807 E L 0.822 Pathogenic MSH6 P52701 E807M 807 E M 0.68 Pathogenic MSH6 P52701 E807N 807 E N 0.042 Neutral MSH6 P52701 E807P 807 E P 0.156 Neutral MSH6 P52701 E807Q 807 E Q 0.032 Neutral MSH6 P52701 E807R 807 E R 0.218 Neutral MSH6 P52701 E807S 807 E S 0.054 Neutral MSH6 P52701 E807T 807 E T 0.082 Neutral MSH6 P52701 E807V 807 E V 0.47 Neutral MSH6 P52701 E807W 807 E W 0.968 Pathogenic MSH6 P52701 E807Y 807 E Y 0.904 Pathogenic MSH6 P52701 V808A 808 V A 0 Neutral MSH6 P52701 V808C 808 V C 0.064 Neutral MSH6 P52701 V808D 808 V D 0.2 Neutral MSH6 P52701 V808E 808 V E 0.33 Neutral MSH6 P52701 V808F 808 V F 0.278 Neutral MSH6 P52701 V808G 808 V G 0.292 Neutral MSH6 P52701 V808H 808 V H 0.24 Neutral MSH6 P52701 V808I 808 V I 0.006 Neutral MSH6 P52701 V808K 808 V K 0.296 Neutral MSH6 P52701 V808L 808 V L 0 Neutral MSH6 P52701 V808M 808 V M 0.036 Neutral MSH6 P52701 V808N 808 V N 0.27 Neutral MSH6 P52701 V808P 808 V P 0.358 Neutral MSH6 P52701 V808Q 808 V Q 0.356 Neutral MSH6 P52701 V808R 808 V R 0.53 Pathogenic MSH6 P52701 V808S 808 V S 0.14 Neutral MSH6 P52701 V808T 808 V T 0.054 Neutral MSH6 P52701 V808W 808 V W 0.574 Pathogenic MSH6 P52701 V808Y 808 V Y 0.32 Neutral MSH6 P52701 V809A 809 V A 0 Neutral MSH6 P52701 V809C 809 V C 0.044 Neutral MSH6 P52701 V809D 809 V D 0.186 Neutral MSH6 P52701 V809E 809 V E 0.316 Neutral MSH6 P52701 V809F 809 V F 0.324 Neutral MSH6 P52701 V809G 809 V G 0.048 Neutral MSH6 P52701 V809H 809 V H 0.22 Neutral MSH6 P52701 V809I 809 V I 0.022 Neutral MSH6 P52701 V809K 809 V K 0.082 Neutral MSH6 P52701 V809L 809 V L 0.004 Neutral MSH6 P52701 V809M 809 V M 0.118 Neutral MSH6 P52701 V809N 809 V N 0.206 Neutral MSH6 P52701 V809P 809 V P 0.338 Neutral MSH6 P52701 V809Q 809 V Q 0.072 Neutral MSH6 P52701 V809R 809 V R 0.316 Neutral MSH6 P52701 V809S 809 V S 0.016 Neutral MSH6 P52701 V809T 809 V T 0.008 Neutral MSH6 P52701 V809W 809 V W 0.55 Pathogenic MSH6 P52701 V809Y 809 V Y 0.47 Neutral MSH6 P52701 A81C 81 A C 0.182 Neutral MSH6 P52701 A81D 81 A D 0.266 Neutral MSH6 P52701 A81E 81 A E 0.306 Neutral MSH6 P52701 A81F 81 A F 0.468 Neutral MSH6 P52701 A81G 81 A G 0.074 Neutral MSH6 P52701 A81H 81 A H 0.304 Neutral MSH6 P52701 A81I 81 A I 0.406 Neutral MSH6 P52701 A81K 81 A K 0.32 Neutral MSH6 P52701 A81L 81 A L 0.414 Neutral MSH6 P52701 A81M 81 A M 0.29 Neutral MSH6 P52701 A81N 81 A N 0.274 Neutral MSH6 P52701 A81P 81 A P 0.04 Neutral MSH6 P52701 A81Q 81 A Q 0.302 Neutral MSH6 P52701 A81R 81 A R 0.36 Neutral MSH6 P52701 A81S 81 A S 0.068 Neutral MSH6 P52701 A81T 81 A T 0.014 Neutral 2 MSH6 P52701 A81V 81 A V 0.074 Neutral MSH6 P52701 A81W 81 A W 0.504 Pathogenic MSH6 P52701 A81Y 81 A Y 0.5 Pathogenic MSH6 P52701 E810A 810 E A 0.08 Neutral MSH6 P52701 E810C 810 E C 0.126 Neutral MSH6 P52701 E810D 810 E D 0.002 Neutral MSH6 P52701 E810F 810 E F 0.432 Neutral MSH6 P52701 E810G 810 E G 0.072 Neutral MSH6 P52701 E810H 810 E H 0.172 Neutral MSH6 P52701 E810I 810 E I 0.342 Neutral MSH6 P52701 E810K 810 E K 0.002 Neutral MSH6 P52701 E810L 810 E L 0.462 Neutral MSH6 P52701 E810M 810 E M 0.294 Neutral MSH6 P52701 E810N 810 E N 0.01 Neutral MSH6 P52701 E810P 810 E P 0.462 Neutral MSH6 P52701 E810Q 810 E Q 0.004 Neutral MSH6 P52701 E810R 810 E R 0.076 Neutral MSH6 P52701 E810S 810 E S 0.018 Neutral MSH6 P52701 E810T 810 E T 0.11 Neutral MSH6 P52701 E810V 810 E V 0.414 Neutral MSH6 P52701 E810W 810 E W 0.696 Pathogenic MSH6 P52701 E810Y 810 E Y 0.582 Pathogenic MSH6 P52701 L811A 811 L A 0.016 Neutral MSH6 P52701 L811C 811 L C 0.014 Neutral MSH6 P52701 L811D 811 L D 0.054 Neutral MSH6 P52701 L811E 811 L E 0.044 Neutral MSH6 P52701 L811F 811 L F 0.206 Neutral MSH6 P52701 L811G 811 L G 0.338 Neutral MSH6 P52701 L811H 811 L H 0.012 Neutral MSH6 P52701 L811I 811 L I 0.004 Neutral MSH6 P52701 L811K 811 L K 0.034 Neutral MSH6 P52701 L811M 811 L M 0.018 Neutral MSH6 P52701 L811N 811 L N 0.162 Neutral MSH6 P52701 L811P 811 L P 0.442 Neutral MSH6 P52701 L811Q 811 L Q 0.014 Neutral MSH6 P52701 L811R 811 L R 0.412 Neutral MSH6 P52701 L811S 811 L S 0.024 Neutral MSH6 P52701 L811T 811 L T 0.028 Neutral MSH6 P52701 L811V 811 L V 0.01 Neutral MSH6 P52701 L811W 811 L W 0.64 Pathogenic MSH6 P52701 L811Y 811 L Y 0.566 Pathogenic MSH6 P52701 L812A 812 L A 0.698 Pathogenic MSH6 P52701 L812C 812 L C 0.816 Pathogenic MSH6 P52701 L812D 812 L D 0.892 Pathogenic MSH6 P52701 L812E 812 L E 0.872 Pathogenic MSH6 P52701 L812F 812 L F 0.474 Neutral MSH6 P52701 L812G 812 L G 0.814 Pathogenic MSH6 P52701 L812H 812 L H 0.904 Pathogenic MSH6 P52701 L812I 812 L I 0.266 Neutral MSH6 P52701 L812K 812 L K 0.738 Pathogenic MSH6 P52701 L812M 812 L M 0.148 Neutral MSH6 P52701 L812N 812 L N 0.762 Pathogenic MSH6 P52701 L812P 812 L P 0.99 Pathogenic MSH6 P52701 L812Q 812 L Q 0.4 Neutral MSH6 P52701 L812R 812 L R 0.98 Pathogenic MSH6 P52701 L812S 812 L S 0.638 Pathogenic MSH6 P52701 L812T 812 L T 0.6 Pathogenic MSH6 P52701 L812V 812 L V 0.518 Pathogenic MSH6 P52701 L812W 812 L W 0.922 Pathogenic MSH6 P52701 L812Y 812 L Y 0.882 Pathogenic MSH6 P52701 K813A 813 K A 0.102 Neutral MSH6 P52701 K813C 813 K C 0.082 Neutral MSH6 P52701 K813D 813 K D 0.238 Neutral MSH6 P52701 K813E 813 K E 0.274 Neutral MSH6 P52701 K813F 813 K F 0.456 Neutral MSH6 P52701 K813G 813 K G 0.124 Neutral MSH6 P52701 K813H 813 K H 0.03 Neutral MSH6 P52701 K813I 813 K I 0.822 Pathogenic MSH6 P52701 K813L 813 K L 0.484 Neutral MSH6 P52701 K813M 813 K M 0.584 Pathogenic MSH6 P52701 K813N 813 K N 0.086 Neutral MSH6 P52701 K813P 813 K P 0.79 Pathogenic MSH6 P52701 K813Q 813 K Q 0.208 Neutral MSH6 P52701 K813R 813 K R 0.036 Neutral MSH6 P52701 K813S 813 K S 0.038 Neutral MSH6 P52701 K813T 813 K T 0.038 Neutral MSH6 P52701 K813V 813 K V 0.138 Neutral MSH6 P52701 K813W 813 K W 0.95 Pathogenic MSH6 P52701 K813Y 813 K Y 0.61 Pathogenic MSH6 P52701 K814A 814 K A 0.508 Pathogenic MSH6 P52701 K814C 814 K C 0.42 Neutral MSH6 P52701 K814D 814 K D 0.588 Pathogenic MSH6 P52701 K814E 814 K E 0.102 Neutral MSH6 P52701 K814F 814 K F 0.91 Pathogenic MSH6 P52701 K814G 814 K G 0.158 Neutral MSH6 P52701 K814H 814 K H 0.236 Neutral MSH6 P52701 K814I 814 K I 0.972 Pathogenic MSH6 P52701 K814L 814 K L 0.956 Pathogenic MSH6 P52701 K814M 814 K M 0.81 Pathogenic MSH6 P52701 K814N 814 K N 0.252 Neutral MSH6 P52701 K814P 814 K P 0.296 Neutral MSH6 P52701 K814Q 814 K Q 0.096 Neutral MSH6 P52701 K814R 814 K R 0.114 Neutral MSH6 P52701 K814S 814 K S 0.128 Neutral MSH6 P52701 K814T 814 K T 0.12 Neutral MSH6 P52701 K814V 814 K V 0.83 Pathogenic MSH6 P52701 K814W 814 K W 0.978 Pathogenic MSH6 P52701 K814Y 814 K Y 0.96 Pathogenic MSH6 P52701 L815A 815 L A 0.57 Pathogenic MSH6 P52701 L815C 815 L C 0.162 Neutral MSH6 P52701 L815D 815 L D 0.91 Pathogenic MSH6 P52701 L815E 815 L E 0.888 Pathogenic MSH6 P52701 L815F 815 L F 0.638 Pathogenic MSH6 P52701 L815G 815 L G 0.806 Pathogenic MSH6 P52701 L815H 815 L H 0.806 Pathogenic MSH6 P52701 L815I 815 L I 0.164 Neutral MSH6 P52701 L815K 815 L K 0.746 Pathogenic MSH6 P52701 L815M 815 L M 0.17 Neutral MSH6 P52701 L815N 815 L N 0.78 Pathogenic MSH6 P52701 L815P 815 L P 0.994 Pathogenic MSH6 P52701 L815Q 815 L Q 0.624 Pathogenic MSH6 P52701 L815R 815 L R 0.712 Pathogenic MSH6 P52701 L815S 815 L S 0.616 Pathogenic MSH6 P52701 L815T 815 L T 0.172 Neutral MSH6 P52701 L815V 815 L V 0.088 Neutral MSH6 P52701 L815W 815 L W 0.928 Pathogenic MSH6 P52701 L815Y 815 L Y 0.888 Pathogenic MSH6 P52701 P816A 816 P A 0.834 Pathogenic MSH6 P52701 P816C 816 P C 0.92 Pathogenic MSH6 P52701 P816D 816 P D 0.87 Pathogenic MSH6 P52701 P816E 816 P E 0.962 Pathogenic MSH6 P52701 P816F 816 P F 1 Pathogenic MSH6 P52701 P816G 816 P G 0.404 Neutral MSH6 P52701 P816H 816 P H 0.98 Pathogenic MSH6 P52701 P816I 816 P I 0.932 Pathogenic MSH6 P52701 P816K 816 P K 0.952 Pathogenic MSH6 P52701 P816L 816 P L 0.864 Pathogenic MSH6 P52701 P816M 816 P M 0.962 Pathogenic MSH6 P52701 P816N 816 P N 0.554 Pathogenic MSH6 P52701 P816Q 816 P Q 0.68 Pathogenic MSH6 P52701 P816R 816 P R 0.988 Pathogenic MSH6 P52701 P816S 816 P S 0.342 Neutral MSH6 P52701 P816T 816 P T 0.746 Pathogenic MSH6 P52701 P816V 816 P V 0.63 Pathogenic MSH6 P52701 P816W 816 P W 0.934 Pathogenic MSH6 P52701 P816Y 816 P Y 0.928 Pathogenic MSH6 P52701 D817A 817 D A 0.79 Pathogenic MSH6 P52701 D817C 817 D C 0.878 Pathogenic MSH6 P52701 D817E 817 D E 0.81 Pathogenic MSH6 P52701 D817F 817 D F 0.98 Pathogenic MSH6 P52701 D817G 817 D G 0.536 Pathogenic MSH6 P52701 D817H 817 D H 0.626 Pathogenic MSH6 P52701 D817I 817 D I 0.974 Pathogenic MSH6 P52701 D817K 817 D K 0.924 Pathogenic MSH6 P52701 D817L 817 D L 0.976 Pathogenic MSH6 P52701 D817M 817 D M 0.956 Pathogenic MSH6 P52701 D817N 817 D N 0.852 Pathogenic MSH6 P52701 D817P 817 D P 0.904 Pathogenic MSH6 P52701 D817Q 817 D Q 0.616 Pathogenic MSH6 P52701 D817R 817 D R 0.958 Pathogenic MSH6 P52701 D817S 817 D S 0.562 Pathogenic MSH6 P52701 D817T 817 D T 0.796 Pathogenic MSH6 P52701 D817V 817 D V 0.996 Pathogenic MSH6 P52701 D817W 817 D W 0.98 Pathogenic MSH6 P52701 D817Y 817 D Y 0.974 Pathogenic MSH6 P52701 L818A 818 L A 0.626 Pathogenic MSH6 P52701 L818C 818 L C 0.326 Neutral MSH6 P52701 L818D 818 L D 0.88 Pathogenic MSH6 P52701 L818E 818 L E 0.86 Pathogenic MSH6 P52701 L818F 818 L F 0.482 Neutral MSH6 P52701 L818G 818 L G 0.792 Pathogenic MSH6 P52701 L818H 818 L H 0.87 Pathogenic MSH6 P52701 L818I 818 L I 0.234 Neutral MSH6 P52701 L818K 818 L K 0.746 Pathogenic MSH6 P52701 L818M 818 L M 0.178 Neutral MSH6 P52701 L818N 818 L N 0.744 Pathogenic MSH6 P52701 L818P 818 L P 0.986 Pathogenic MSH6 P52701 L818Q 818 L Q 0.678 Pathogenic MSH6 P52701 L818R 818 L R 0.98 Pathogenic MSH6 P52701 L818S 818 L S 0.622 Pathogenic MSH6 P52701 L818T 818 L T 0.594 Pathogenic MSH6 P52701 L818V 818 L V 0.11 Neutral MSH6 P52701 L818W 818 L W 0.94 Pathogenic MSH6 P52701 L818Y 818 L Y 0.898 Pathogenic MSH6 P52701 E819A 819 E A 0.572 Pathogenic MSH6 P52701 E819C 819 E C 0.754 Pathogenic MSH6 P52701 E819D 819 E D 0.386 Neutral MSH6 P52701 E819F 819 E F 0.96 Pathogenic MSH6 P52701 E819G 819 E G 0.346 Neutral MSH6 P52701 E819H 819 E H 0.722 Pathogenic MSH6 P52701 E819I 819 E I 0.978 Pathogenic MSH6 P52701 E819K 819 E K 0.732 Pathogenic MSH6 P52701 E819L 819 E L 0.97 Pathogenic MSH6 P52701 E819M 819 E M 0.902 Pathogenic MSH6 P52701 E819N 819 E N 0.776 Pathogenic MSH6 P52701 E819P 819 E P 0.936 Pathogenic MSH6 P52701 E819Q 819 E Q 0.85 Pathogenic MSH6 P52701 E819R 819 E R 0.708 Pathogenic MSH6 P52701 E819S 819 E S 0.894 Pathogenic MSH6 P52701 E819T 819 E T 0.844 Pathogenic MSH6 P52701 E819V 819 E V 0.918 Pathogenic MSH6 P52701 E819W 819 E W 0.98 Pathogenic MSH6 P52701 E819Y 819 E Y 0.96 Pathogenic MSH6 P52701 P82A 82 P A 0.032 Neutral MSH6 P52701 P82C 82 P C 0.148 Neutral MSH6 P52701 P82D 82 P D 0.078 Neutral MSH6 P52701 P82E 82 P E 0.214 Neutral MSH6 P52701 P82F 82 P F 0.226 Neutral MSH6 P52701 P82G 82 P G 0.092 Neutral MSH6 P52701 P82H 82 P H 0.266 Neutral MSH6 P52701 P82I 82 P I 0.104 Neutral MSH6 P52701 P82K 82 P K 0.144 Neutral MSH6 P52701 P82L 82 P L 0.096 Neutral MSH6 P52701 P82M 82 P M 0.22 Neutral MSH6 P52701 P82N 82 P N 0.068 Neutral MSH6 P52701 P82Q 82 P Q 0.15 Neutral MSH6 P52701 P82R 82 P R 0.202 Neutral MSH6 P52701 P82S 82 P S 0.092 Neutral MSH6 P52701 P82T 82 P T 0.014 Neutral MSH6 P52701 P82V 82 P V 0.13 Neutral MSH6 P52701 P82W 82 P W 0.39 Neutral MSH6 P52701 P82Y 82 P Y 0.32 Neutral MSH6 P52701 R820A 820 R A 0.572 Pathogenic MSH6 P52701 R820C 820 R C 0.954 Pathogenic MSH6 P52701 R820D 820 R D 0.688 Pathogenic MSH6 P52701 R820E 820 R E 0.794 Pathogenic MSH6 P52701 R820F 820 R F 0.976 Pathogenic MSH6 P52701 R820G 820 R G 0.27 Neutral MSH6 P52701 R820H 820 R H 0.388 Neutral MSH6 P52701 R820I 820 R I 0.976 Pathogenic MSH6 P52701 R820K 820 R K 0.484 Neutral MSH6 P52701 R820L 820 R L 0.99 Pathogenic MSH6 P52701 R820M 820 R M 0.784 Pathogenic MSH6 P52701 R820N 820 R N 0.646 Pathogenic MSH6 P52701 R820P 820 R P 0.988 Pathogenic MSH6 P52701 R820Q 820 R Q 0.502 Pathogenic MSH6 P52701 R820S 820 R S 0.914 Pathogenic MSH6 P52701 R820T 820 R T 0.94 Pathogenic MSH6 P52701 R820V 820 R V 0.976 Pathogenic MSH6 P52701 R820W 820 R W 0.958 Pathogenic MSH6 P52701 R820Y 820 R Y 0.966 Pathogenic MSH6 P52701 L821A 821 L A 0.664 Pathogenic MSH6 P52701 L821C 821 L C 0.784 Pathogenic MSH6 P52701 L821D 821 L D 0.896 Pathogenic MSH6 P52701 L821E 821 L E 0.872 Pathogenic MSH6 P52701 L821F 821 L F 0.974 Pathogenic MSH6 P52701 L821G 821 L G 0.464 Neutral MSH6 P52701 L821H 821 L H 0.228 Neutral MSH6 P52701 L821I 821 L I 0.244 Neutral MSH6 P52701 L821K 821 L K 0.758 Pathogenic MSH6 P52701 L821M 821 L M 0.172 Neutral MSH6 P52701 L821N 821 L N 0.204 Neutral MSH6 P52701 L821P 821 L P 0.992 Pathogenic MSH6 P52701 L821Q 821 L Q 0.212 Neutral MSH6 P52701 L821R 821 L R 0.984 Pathogenic MSH6 P52701 L821S 821 L S 0.646 Pathogenic MSH6 P52701 L821T 821 L T 0.306 Neutral MSH6 P52701 L821V 821 L V 0.152 Neutral MSH6 P52701 L821W 821 L W 0.938 Pathogenic MSH6 P52701 L821Y 821 L Y 0.8 Pathogenic MSH6 P52701 L822A 822 L A 0.566 Pathogenic MSH6 P52701 L822C 822 L C 0.692 Pathogenic MSH6 P52701 L822D 822 L D 0.886 Pathogenic MSH6 P52701 L822E 822 L E 0.872 Pathogenic MSH6 P52701 L822F 822 L F 0.556 Pathogenic MSH6 P52701 L822G 822 L G 0.468 Neutral MSH6 P52701 L822H 822 L H 0.822 Pathogenic MSH6 P52701 L822I 822 L I 0.154 Neutral MSH6 P52701 L822K 822 L K 0.742 Pathogenic MSH6 P52701 L822M 822 L M 0.742 Pathogenic MSH6 P52701 L822N 822 L N 0.752 Pathogenic MSH6 P52701 L822P 822 L P 0.986 Pathogenic MSH6 P52701 L822Q 822 L Q 0.624 Pathogenic MSH6 P52701 L822R 822 L R 0.99 Pathogenic MSH6 P52701 L822S 822 L S 0.596 Pathogenic MSH6 P52701 L822T 822 L T 0.578 Pathogenic MSH6 P52701 L822V 822 L V 0.088 Neutral MSH6 P52701 L822W 822 L W 0.94 Pathogenic MSH6 P52701 L822Y 822 L Y 0.906 Pathogenic MSH6 P52701 S823A 823 S A 0.01 Neutral MSH6 P52701 S823C 823 S C 0.076 Neutral MSH6 P52701 S823D 823 S D 0.006 Neutral MSH6 P52701 S823E 823 S E 0.22 Neutral MSH6 P52701 S823F 823 S F 0.532 Pathogenic MSH6 P52701 S823G 823 S G 0.002 Neutral MSH6 P52701 S823H 823 S H 0.452 Neutral MSH6 P52701 S823I 823 S I 0.242 Neutral MSH6 P52701 S823K 823 S K 0.34 Neutral MSH6 P52701 S823L 823 S L 0.212 Neutral MSH6 P52701 S823M 823 S M 0.634 Pathogenic MSH6 P52701 S823N 823 S N 0.006 Neutral MSH6 P52701 S823P 823 S P 0.228 Neutral MSH6 P52701 S823Q 823 S Q 0.294 Neutral MSH6 P52701 S823R 823 S R 0.256 Neutral MSH6 P52701 S823T 823 S T 0.02 Neutral MSH6 P52701 S823V 823 S V 0.414 Neutral MSH6 P52701 S823W 823 S W 0.762 Pathogenic MSH6 P52701 S823Y 823 S Y 0.718 Pathogenic MSH6 P52701 K824A 824 K A 0.034 Neutral MSH6 P52701 K824C 824 K C 0.064 Neutral MSH6 P52701 K824D 824 K D 0.086 Neutral MSH6 P52701 K824E 824 K E 0.016 Neutral MSH6 P52701 K824F 824 K F 0.364 Neutral MSH6 P52701 K824G 824 K G 0.182 Neutral MSH6 P52701 K824H 824 K H 0.084 Neutral MSH6 P52701 K824I 824 K I 0.228 Neutral MSH6 P52701 K824L 824 K L 0.334 Neutral MSH6 P52701 K824M 824 K M 0.186 Neutral MSH6 P52701 K824N 824 K N 0.13 Neutral MSH6 P52701 K824P 824 K P 0.398 Neutral MSH6 P52701 K824Q 824 K Q 0.01 Neutral MSH6 P52701 K824R 824 K R 0.006 Neutral MSH6 P52701 K824S 824 K S 0.014 Neutral MSH6 P52701 K824T 824 K T 0.142 Neutral MSH6 P52701 K824V 824 K V 0.338 Neutral MSH6 P52701 K824W 824 K W 0.706 Pathogenic MSH6 P52701 K824Y 824 K Y 0.584 Pathogenic MSH6 P52701 I825A 825 I A 0.262 Neutral MSH6 P52701 I825C 825 I C 0.332 Neutral MSH6 P52701 I825D 825 I D 0.514 Pathogenic MSH6 P52701 I825E 825 I E 0.098 Neutral MSH6 P52701 I825F 825 I F 0.346 Neutral MSH6 P52701 I825G 825 I G 0.534 Pathogenic MSH6 P52701 I825H 825 I H 0.344 Neutral MSH6 P52701 I825K 825 I K 0.098 Neutral MSH6 P52701 I825L 825 I L 0.442 Neutral MSH6 P52701 I825M 825 I M 0.376 Neutral MSH6 P52701 I825N 825 I N 0.562 Pathogenic MSH6 P52701 I825P 825 I P 0.13 Neutral MSH6 P52701 I825Q 825 I Q 0.348 Neutral MSH6 P52701 I825R 825 I R 0.496 Neutral MSH6 P52701 I825S 825 I S 0.132 Neutral MSH6 P52701 I825T 825 I T 0.528 Pathogenic MSH6 P52701 I825V 825 I V 0.1 Neutral MSH6 P52701 I825W 825 I W 0.778 Pathogenic MSH6 P52701 I825Y 825 I Y 0.786 Pathogenic MSH6 P52701 H826A 826 H A 0.184 Neutral MSH6 P52701 H826C 826 H C 0.142 Neutral MSH6 P52701 H826D 826 H D 0.004 Neutral MSH6 P52701 H826E 826 H E 0.002 Neutral MSH6 P52701 H826F 826 H F 0.49 Neutral MSH6 P52701 H826G 826 H G 0.29 Neutral MSH6 P52701 H826I 826 H I 0.548 Pathogenic MSH6 P52701 H826K 826 H K 0.018 Neutral MSH6 P52701 H826L 826 H L 0.51 Pathogenic MSH6 P52701 H826M 826 H M 0.338 Neutral MSH6 P52701 H826N 826 H N 0.03 Neutral MSH6 P52701 H826P 826 H P 0.634 Pathogenic MSH6 P52701 H826Q 826 H Q 0.198 Neutral MSH6 P52701 H826R 826 H R 0.15 Neutral MSH6 P52701 H826S 826 H S 0.024 Neutral MSH6 P52701 H826T 826 H T 0.434 Neutral MSH6 P52701 H826V 826 H V 0.384 Neutral MSH6 P52701 H826W 826 H W 0.776 Pathogenic MSH6 P52701 H826Y 826 H Y 0.126 Neutral MSH6 P52701 N827A 827 N A 0.004 Neutral MSH6 P52701 N827C 827 N C 0.148 Neutral MSH6 P52701 N827D 827 N D 0.084 Neutral MSH6 P52701 N827E 827 N E 0.152 Neutral MSH6 P52701 N827F 827 N F 0.34 Neutral MSH6 P52701 N827G 827 N G 0.022 Neutral MSH6 P52701 N827H 827 N H 0.024 Neutral MSH6 P52701 N827I 827 N I 0.266 Neutral MSH6 P52701 N827K 827 N K 0.224 Neutral MSH6 P52701 N827L 827 N L 0.086 Neutral MSH6 P52701 N827M 827 N M 0.22 Neutral MSH6 P52701 N827P 827 N P 0.248 Neutral MSH6 P52701 N827Q 827 N Q 0.096 Neutral MSH6 P52701 N827R 827 N R 0.158 Neutral MSH6 P52701 N827S 827 N S 0 Neutral MSH6 P52701 N827T 827 N T 0.006 Neutral MSH6 P52701 N827V 827 N V 0.032 Neutral MSH6 P52701 N827W 827 N W 0.446 Neutral MSH6 P52701 N827Y 827 N Y 0.402 Neutral MSH6 P52701 V828A 828 V A 0.052 Neutral MSH6 P52701 V828C 828 V C 0.058 Neutral MSH6 P52701 V828D 828 V D 0.13 Neutral MSH6 P52701 V828E 828 V E 0.176 Neutral MSH6 P52701 V828F 828 V F 0.166 Neutral MSH6 P52701 V828G 828 V G 0.198 Neutral MSH6 P52701 V828H 828 V H 0.116 Neutral MSH6 P52701 V828I 828 V I 0.002 Neutral MSH6 P52701 V828K 828 V K 0.174 Neutral MSH6 P52701 V828L 828 V L 0 Neutral MSH6 P52701 V828M 828 V M 0.014 Neutral MSH6 P52701 V828N 828 V N 0.142 Neutral MSH6 P52701 V828P 828 V P 0.038 Neutral MSH6 P52701 V828Q 828 V Q 0.052 Neutral MSH6 P52701 V828R 828 V R 0.288 Neutral MSH6 P52701 V828S 828 V S 0.07 Neutral MSH6 P52701 V828T 828 V T 0.094 Neutral MSH6 P52701 V828W 828 V W 0.348 Neutral MSH6 P52701 V828Y 828 V Y 0.144 Neutral MSH6 P52701 G829A 829 G A 0.486 Neutral MSH6 P52701 G829C 829 G C 0.678 Pathogenic MSH6 P52701 G829D 829 G D 0.708 Pathogenic MSH6 P52701 G829E 829 G E 0.888 Pathogenic MSH6 P52701 G829F 829 G F 0.94 Pathogenic MSH6 P52701 G829H 829 G H 0.936 Pathogenic MSH6 P52701 G829I 829 G I 0.908 Pathogenic MSH6 P52701 G829K 829 G K 0.938 Pathogenic MSH6 P52701 G829L 829 G L 0.91 Pathogenic MSH6 P52701 G829M 829 G M 0.942 Pathogenic MSH6 P52701 G829N 829 G N 0.688 Pathogenic MSH6 P52701 G829P 829 G P 0.872 Pathogenic MSH6 P52701 G829Q 829 G Q 0.76 Pathogenic MSH6 P52701 G829R 829 G R 0.956 Pathogenic MSH6 P52701 G829S 829 G S 0.15 Neutral MSH6 P52701 G829T 829 G T 0.79 Pathogenic MSH6 P52701 G829V 829 G V 0.916 Pathogenic MSH6 P52701 G829W 829 G W 0.932 Pathogenic MSH6 P52701 G829Y 829 G Y 0.922 Pathogenic MSH6 P52701 A83C 83 A C 0.212 Neutral MSH6 P52701 A83D 83 A D 0.266 Neutral MSH6 P52701 A83E 83 A E 0.276 Neutral MSH6 P52701 A83F 83 A F 0.408 Neutral MSH6 P52701 A83G 83 A G 0.12 Neutral MSH6 P52701 A83H 83 A H 0.304 Neutral MSH6 P52701 A83I 83 A I 0.406 Neutral MSH6 P52701 A83K 83 A K 0.272 Neutral MSH6 P52701 A83L 83 A L 0.4 Neutral MSH6 P52701 A83M 83 A M 0.29 Neutral MSH6 P52701 A83N 83 A N 0.274 Neutral MSH6 P52701 A83P 83 A P 0.038 Neutral MSH6 P52701 A83Q 83 A Q 0.302 Neutral MSH6 P52701 A83R 83 A R 0.36 Neutral MSH6 P52701 A83S 83 A S 0.068 Neutral MSH6 P52701 A83T 83 A T 0.166 Neutral MSH6 P52701 A83V 83 A V 0.242 Neutral MSH6 P52701 A83W 83 A W 0.504 Pathogenic MSH6 P52701 A83Y 83 A Y 0.5 Pathogenic MSH6 P52701 S830A 830 S A 0.096 Neutral MSH6 P52701 S830C 830 S C 0.058 Neutral MSH6 P52701 S830D 830 S D 0.116 Neutral MSH6 P52701 S830E 830 S E 0.328 Neutral MSH6 P52701 S830F 830 S F 0.492 Neutral MSH6 P52701 S830G 830 S G 0.118 Neutral MSH6 P52701 S830H 830 S H 0.444 Neutral MSH6 P52701 S830I 830 S I 0.168 Neutral MSH6 P52701 S830K 830 S K 0.372 Neutral MSH6 P52701 S830L 830 S L 0.058 Neutral MSH6 P52701 S830M 830 S M 0.626 Pathogenic MSH6 P52701 S830N 830 S N 0.006 Neutral MSH6 P52701 S830P 830 S P 0.212 Neutral MSH6 P52701 S830Q 830 S Q 0.318 Neutral MSH6 P52701 S830R 830 S R 0.444 Neutral MSH6 P52701 S830T 830 S T 0.02 Neutral MSH6 P52701 S830V 830 S V 0.404 Neutral MSH6 P52701 S830W 830 S W 0.74 Pathogenic MSH6 P52701 S830Y 830 S Y 0.696 Pathogenic MSH6 P52701 P831A 831 P A 0.044 Neutral MSH6 P52701 P831C 831 P C 0.246 Neutral MSH6 P52701 P831D 831 P D 0.14 Neutral MSH6 P52701 P831E 831 P E 0.374 Neutral MSH6 P52701 P831F 831 P F 0.528 Pathogenic MSH6 P52701 P831G 831 P G 0.14 Neutral MSH6 P52701 P831H 831 P H 0.488 Neutral MSH6 P52701 P831I 831 P I 0.222 Neutral MSH6 P52701 P831K 831 P K 0.08 Neutral MSH6 P52701 P831L 831 P L 0.07 Neutral MSH6 P52701 P831M 831 P M 0.392 Neutral MSH6 P52701 P831N 831 P N 0.036 Neutral MSH6 P52701 P831Q 831 P Q 0.376 Neutral MSH6 P52701 P831R 831 P R 0.542 Pathogenic MSH6 P52701 P831S 831 P S 0.012 Neutral MSH6 P52701 P831T 831 P T 0.2 Neutral MSH6 P52701 P831V 831 P V 0.268 Neutral MSH6 P52701 P831W 831 P W 0.624 Pathogenic MSH6 P52701 P831Y 831 P Y 0.556 Pathogenic MSH6 P52701 L832A 832 L A 0.008 Neutral MSH6 P52701 L832C 832 L C 0.094 Neutral MSH6 P52701 L832D 832 L D 0.06 Neutral MSH6 P52701 L832E 832 L E 0.07 Neutral MSH6 P52701 L832F 832 L F 0.222 Neutral MSH6 P52701 L832G 832 L G 0.054 Neutral MSH6 P52701 L832H 832 L H 0.084 Neutral MSH6 P52701 L832I 832 L I 0.03 Neutral MSH6 P52701 L832K 832 L K 0.026 Neutral MSH6 P52701 L832M 832 L M 0.134 Neutral MSH6 P52701 L832N 832 L N 0.146 Neutral MSH6 P52701 L832P 832 L P 0.234 Neutral MSH6 P52701 L832Q 832 L Q 0.004 Neutral MSH6 P52701 L832R 832 L R 0.282 Neutral MSH6 P52701 L832S 832 L S 0.206 Neutral MSH6 P52701 L832T 832 L T 0.182 Neutral MSH6 P52701 L832V 832 L V 0.172 Neutral MSH6 P52701 L832W 832 L W 0.384 Neutral MSH6 P52701 L832Y 832 L Y 0.338 Neutral MSH6 P52701 K833A 833 K A 0.03 Neutral MSH6 P52701 K833C 833 K C 0.048 Neutral MSH6 P52701 K833D 833 K D 0.09 Neutral MSH6 P52701 K833E 833 K E 0.012 Neutral MSH6 P52701 K833F 833 K F 0.284 Neutral MSH6 P52701 K833G 833 K G 0.064 Neutral MSH6 P52701 K833H 833 K H 0.072 Neutral MSH6 P52701 K833I 833 K I 0.308 Neutral MSH6 P52701 K833L 833 K L 0.132 Neutral MSH6 P52701 K833M 833 K M 0.026 Neutral MSH6 P52701 K833N 833 K N 0.06 Neutral MSH6 P52701 K833P 833 K P 0.102 Neutral MSH6 P52701 K833Q 833 K Q 0.026 Neutral MSH6 P52701 K833R 833 K R 0.004 Neutral MSH6 P52701 K833S 833 K S 0.016 Neutral MSH6 P52701 K833T 833 K T 0.104 Neutral MSH6 P52701 K833V 833 K V 0.23 Neutral MSH6 P52701 K833W 833 K W 0.582 Pathogenic MSH6 P52701 K833Y 833 K Y 0.48 Neutral MSH6 P52701 S834A 834 S A 0.086 Neutral MSH6 P52701 S834C 834 S C 0.008 Neutral MSH6 P52701 S834D 834 S D 0.044 Neutral MSH6 P52701 S834E 834 S E 0.124 Neutral MSH6 P52701 S834F 834 S F 0.28 Neutral MSH6 P52701 S834G 834 S G 0 Neutral MSH6 P52701 S834H 834 S H 0.242 Neutral MSH6 P52701 S834I 834 S I 0.172 Neutral MSH6 P52701 S834K 834 S K 0.164 Neutral MSH6 P52701 S834L 834 S L 0.07 Neutral MSH6 P52701 S834M 834 S M 0.35 Neutral MSH6 P52701 S834N 834 S N 0 Neutral MSH6 P52701 S834P 834 S P 0.132 Neutral MSH6 P52701 S834Q 834 S Q 0.188 Neutral MSH6 P52701 S834R 834 S R 0.176 Neutral MSH6 P52701 S834T 834 S T 0.104 Neutral MSH6 P52701 S834V 834 S V 0.298 Neutral MSH6 P52701 S834W 834 S W 0.502 Pathogenic MSH6 P52701 S834Y 834 S Y 0.458 Neutral MSH6 P52701 Q835A 835 Q A 0.08 Neutral MSH6 P52701 Q835C 835 Q C 0.082 Neutral MSH6 P52701 Q835D 835 Q D 0 Neutral MSH6 P52701 Q835E 835 Q E 0.008 Neutral MSH6 P52701 Q835F 835 Q F 0.26 Neutral MSH6 P52701 Q835G 835 Q G 0.106 Neutral MSH6 P52701 Q835H 835 Q H 0.214 Neutral MSH6 P52701 Q835I 835 Q I 0.278 Neutral MSH6 P52701 Q835K 835 Q K 0.02 Neutral MSH6 P52701 Q835L 835 Q L 0.242 Neutral MSH6 P52701 Q835M 835 Q M 0.054 Neutral MSH6 P52701 Q835N 835 Q N 0.018 Neutral MSH6 P52701 Q835P 835 Q P 0.368 Neutral MSH6 P52701 Q835R 835 Q R 0.008 Neutral MSH6 P52701 Q835S 835 Q S 0.034 Neutral MSH6 P52701 Q835T 835 Q T 0.002 Neutral MSH6 P52701 Q835V 835 Q V 0.268 Neutral MSH6 P52701 Q835W 835 Q W 0.42 Neutral MSH6 P52701 Q835Y 835 Q Y 0.452 Neutral MSH6 P52701 N836A 836 N A 0.096 Neutral MSH6 P52701 N836C 836 N C 0.154 Neutral MSH6 P52701 N836D 836 N D 0.006 Neutral MSH6 P52701 N836E 836 N E 0.016 Neutral MSH6 P52701 N836F 836 N F 0.492 Neutral MSH6 P52701 N836G 836 N G 0.162 Neutral MSH6 P52701 N836H 836 N H 0.246 Neutral MSH6 P52701 N836I 836 N I 0.292 Neutral MSH6 P52701 N836K 836 N K 0.082 Neutral MSH6 P52701 N836L 836 N L 0.294 Neutral MSH6 P52701 N836M 836 N M 0.242 Neutral MSH6 P52701 N836P 836 N P 0.26 Neutral MSH6 P52701 N836Q 836 N Q 0.17 Neutral MSH6 P52701 N836R 836 N R 0.208 Neutral MSH6 P52701 N836S 836 N S 0 Neutral MSH6 P52701 N836T 836 N T 0.024 Neutral MSH6 P52701 N836V 836 N V 0.304 Neutral MSH6 P52701 N836W 836 N W 0.524 Pathogenic MSH6 P52701 N836Y 836 N Y 0.47 Neutral MSH6 P52701 H837A 837 H A 0.31 Neutral MSH6 P52701 H837C 837 H C 0.24 Neutral MSH6 P52701 H837D 837 H D 0.126 Neutral MSH6 P52701 H837E 837 H E 0.008 Neutral MSH6 P52701 H837F 837 H F 0.74 Pathogenic MSH6 P52701 H837G 837 H G 0.288 Neutral MSH6 P52701 H837I 837 H I 0.764 Pathogenic MSH6 P52701 H837K 837 H K 0.136 Neutral MSH6 P52701 H837L 837 H L 0.68 Pathogenic MSH6 P52701 H837M 837 H M 0.578 Pathogenic MSH6 P52701 H837N 837 H N 0.172 Neutral MSH6 P52701 H837P 837 H P 0.896 Pathogenic MSH6 P52701 H837Q 837 H Q 0.316 Neutral MSH6 P52701 H837R 837 H R 0.348 Neutral MSH6 P52701 H837S 837 H S 0.412 Neutral MSH6 P52701 H837T 837 H T 0.458 Neutral MSH6 P52701 H837V 837 H V 0.51 Pathogenic MSH6 P52701 H837W 837 H W 0.95 Pathogenic MSH6 P52701 H837Y 837 H Y 0.782 Pathogenic MSH6 P52701 P838A 838 P A 0.074 Neutral MSH6 P52701 P838C 838 P C 0.624 Pathogenic MSH6 P52701 P838D 838 P D 0.272 Neutral MSH6 P52701 P838E 838 P E 0.19 Neutral MSH6 P52701 P838F 838 P F 0.978 Pathogenic MSH6 P52701 P838G 838 P G 0.292 Neutral MSH6 P52701 P838H 838 P H 0.858 Pathogenic MSH6 P52701 P838I 838 P I 0.67 Pathogenic MSH6 P52701 P838K 838 P K 0.146 Neutral MSH6 P52701 P838L 838 P L 0.748 Pathogenic MSH6 P52701 P838M 838 P M 0.736 Pathogenic MSH6 P52701 P838N 838 P N 0.34 Neutral MSH6 P52701 P838Q 838 P Q 0.54 Pathogenic MSH6 P52701 P838R 838 P R 0.75 Pathogenic MSH6 P52701 P838S 838 P S 0.336 Neutral MSH6 P52701 P838T 838 P T 0.48 Neutral MSH6 P52701 P838V 838 P V 0.622 Pathogenic MSH6 P52701 P838W 838 P W 0.924 Pathogenic MSH6 P52701 P838Y 838 P Y 0.906 Pathogenic MSH6 P52701 D839A 839 D A 0.122 Neutral MSH6 P52701 D839C 839 D C 0.64 Pathogenic MSH6 P52701 D839E 839 D E 0.064 Neutral MSH6 P52701 D839F 839 D F 0.944 Pathogenic MSH6 P52701 D839G 839 D G 0.112 Neutral MSH6 P52701 D839H 839 D H 0.528 Pathogenic MSH6 P52701 D839I 839 D I 0.828 Pathogenic MSH6 P52701 D839K 839 D K 0.368 Neutral MSH6 P52701 D839L 839 D L 0.916 Pathogenic MSH6 P52701 D839M 839 D M 0.822 Pathogenic MSH6 P52701 D839N 839 D N 0.032 Neutral MSH6 P52701 D839P 839 D P 0.824 Pathogenic MSH6 P52701 D839Q 839 D Q 0.44 Neutral MSH6 P52701 D839R 839 D R 0.62 Pathogenic MSH6 P52701 D839S 839 D S 0.058 Neutral MSH6 P52701 D839T 839 D T 0.516 Pathogenic MSH6 P52701 D839V 839 D V 0.942 Pathogenic MSH6 P52701 D839W 839 D W 0.974 Pathogenic MSH6 P52701 D839Y 839 D Y 0.968 Pathogenic MSH6 P52701 A84C 84 A C 0.212 Neutral MSH6 P52701 A84D 84 A D 0.266 Neutral MSH6 P52701 A84E 84 A E 0.272 Neutral MSH6 P52701 A84F 84 A F 0.296 Neutral MSH6 P52701 A84G 84 A G 0.12 Neutral MSH6 P52701 A84H 84 A H 0.304 Neutral MSH6 P52701 A84I 84 A I 0.406 Neutral MSH6 P52701 A84K 84 A K 0.354 Neutral MSH6 P52701 A84L 84 A L 0.4 Neutral MSH6 P52701 A84M 84 A M 0.29 Neutral MSH6 P52701 A84N 84 A N 0.296 Neutral MSH6 P52701 A84P 84 A P 0.036 Neutral MSH6 P52701 A84Q 84 A Q 0.278 Neutral MSH6 P52701 A84R 84 A R 0.36 Neutral MSH6 P52701 A84S 84 A S 0.008 Neutral MSH6 P52701 A84T 84 A T 0.166 Neutral MSH6 P52701 A84V 84 A V 0.04 Neutral MSH6 P52701 A84W 84 A W 0.484 Neutral MSH6 P52701 A84Y 84 A Y 0.5 Pathogenic MSH6 P52701 S840A 840 S A 0.068 Neutral MSH6 P52701 S840C 840 S C 0.332 Neutral MSH6 P52701 S840D 840 S D 0.36 Neutral MSH6 P52701 S840E 840 S E 0.482 Neutral MSH6 P52701 S840F 840 S F 0.78 Pathogenic MSH6 P52701 S840G 840 S G 0.046 Neutral MSH6 P52701 S840H 840 S H 0.822 Pathogenic MSH6 P52701 S840I 840 S I 0.646 Pathogenic MSH6 P52701 S840K 840 S K 0.468 Neutral MSH6 P52701 S840L 840 S L 0.666 Pathogenic MSH6 P52701 S840M 840 S M 0.948 Pathogenic MSH6 P52701 S840N 840 S N 0.062 Neutral MSH6 P52701 S840P 840 S P 0.688 Pathogenic MSH6 P52701 S840Q 840 S Q 0.562 Pathogenic MSH6 P52701 S840R 840 S R 0.574 Pathogenic MSH6 P52701 S840T 840 S T 0.086 Neutral MSH6 P52701 S840V 840 S V 0.764 Pathogenic MSH6 P52701 S840W 840 S W 0.914 Pathogenic MSH6 P52701 S840Y 840 S Y 0.9 Pathogenic MSH6 P52701 R841A 841 R A 0.164 Neutral MSH6 P52701 R841C 841 R C 0.94 Pathogenic MSH6 P52701 R841D 841 R D 0.862 Pathogenic MSH6 P52701 R841E 841 R E 0.826 Pathogenic MSH6 P52701 R841F 841 R F 0.972 Pathogenic MSH6 P52701 R841G 841 R G 0.406 Neutral MSH6 P52701 R841H 841 R H 0.232 Neutral MSH6 P52701 R841I 841 R I 0.512 Pathogenic MSH6 P52701 R841K 841 R K 0.358 Neutral MSH6 P52701 R841L 841 R L 0.984 Pathogenic MSH6 P52701 R841M 841 R M 0.798 Pathogenic MSH6 P52701 R841N 841 R N 0.132 Neutral MSH6 P52701 R841P 841 R P 0.984 Pathogenic MSH6 P52701 R841Q 841 R Q 0.362 Neutral MSH6 P52701 R841S 841 R S 0.168 Neutral MSH6 P52701 R841T 841 R T 0.184 Neutral MSH6 P52701 R841V 841 R V 0.35 Neutral MSH6 P52701 R841W 841 R W 0.968 Pathogenic MSH6 P52701 R841Y 841 R Y 0.97 Pathogenic MSH6 P52701 A842C 842 A C 0.334 Neutral MSH6 P52701 A842D 842 A D 0.77 Pathogenic MSH6 P52701 A842E 842 A E 0.84 Pathogenic MSH6 P52701 A842F 842 A F 0.904 Pathogenic MSH6 P52701 A842G 842 A G 0.624 Pathogenic MSH6 P52701 A842H 842 A H 0.682 Pathogenic MSH6 P52701 A842I 842 A I 0.794 Pathogenic MSH6 P52701 A842K 842 A K 0.856 Pathogenic MSH6 P52701 A842L 842 A L 0.9 Pathogenic MSH6 P52701 A842M 842 A M 0.754 Pathogenic MSH6 P52701 A842N 842 A N 0.556 Pathogenic MSH6 P52701 A842P 842 A P 0.872 Pathogenic MSH6 P52701 A842Q 842 A Q 0.826 Pathogenic MSH6 P52701 A842R 842 A R 0.772 Pathogenic MSH6 P52701 A842S 842 A S 0.118 Neutral MSH6 P52701 A842T 842 A T 0.402 Neutral MSH6 P52701 A842V 842 A V 0.766 Pathogenic MSH6 P52701 A842W 842 A W 0.904 Pathogenic MSH6 P52701 A842Y 842 A Y 0.868 Pathogenic MSH6 P52701 I843A 843 I A 0.072 Neutral MSH6 P52701 I843C 843 I C 0.384 Neutral MSH6 P52701 I843D 843 I D 0.3 Neutral MSH6 P52701 I843E 843 I E 0.552 Pathogenic MSH6 P52701 I843F 843 I F 0.684 Pathogenic MSH6 P52701 I843G 843 I G 0.254 Neutral MSH6 P52701 I843H 843 I H 0.43 Neutral MSH6 P52701 I843K 843 I K 0.086 Neutral MSH6 P52701 I843L 843 I L 0.482 Neutral MSH6 P52701 I843M 843 I M 0.384 Neutral MSH6 P52701 I843N 843 I N 0.614 Pathogenic MSH6 P52701 I843P 843 I P 0.612 Pathogenic MSH6 P52701 I843Q 843 I Q 0.174 Neutral MSH6 P52701 I843R 843 I R 0.552 Pathogenic MSH6 P52701 I843S 843 I S 0.114 Neutral MSH6 P52701 I843T 843 I T 0.338 Neutral MSH6 P52701 I843V 843 I V 0.012 Neutral MSH6 P52701 I843W 843 I W 0.898 Pathogenic MSH6 P52701 I843Y 843 I Y 0.904 Pathogenic MSH6 P52701 M844A 844 M A 0.068 Neutral MSH6 P52701 M844C 844 M C 0.112 Neutral MSH6 P52701 M844D 844 M D 0.112 Neutral MSH6 P52701 M844E 844 M E 0.176 Neutral MSH6 P52701 M844F 844 M F 0.038 Neutral MSH6 P52701 M844G 844 M G 0.294 Neutral MSH6 P52701 M844H 844 M H 0.114 Neutral MSH6 P52701 M844I 844 M I 0.158 Neutral MSH6 P52701 M844K 844 M K 0.24 Neutral MSH6 P52701 M844L 844 M L 0.022 Neutral MSH6 P52701 M844N 844 M N 0.07 Neutral MSH6 P52701 M844P 844 M P 0.062 Neutral MSH6 P52701 M844Q 844 M Q 0.148 Neutral MSH6 P52701 M844R 844 M R 0.386 Neutral MSH6 P52701 M844S 844 M S 0.044 Neutral MSH6 P52701 M844T 844 M T 0.326 Neutral MSH6 P52701 M844V 844 M V 0.042 Neutral MSH6 P52701 M844W 844 M W 0.77 Pathogenic MSH6 P52701 M844Y 844 M Y 0.38 Neutral MSH6 P52701 Y845A 845 Y A 0.31 Neutral MSH6 P52701 Y845C 845 Y C 0.31 Neutral MSH6 P52701 Y845D 845 Y D 0.544 Pathogenic MSH6 P52701 Y845E 845 Y E 0.162 Neutral MSH6 P52701 Y845F 845 Y F 0.042 Neutral MSH6 P52701 Y845G 845 Y G 0.264 Neutral MSH6 P52701 Y845H 845 Y H 0.206 Neutral MSH6 P52701 Y845I 845 Y I 0.362 Neutral MSH6 P52701 Y845K 845 Y K 0.064 Neutral MSH6 P52701 Y845L 845 Y L 0.22 Neutral MSH6 P52701 Y845M 845 Y M 0.304 Neutral MSH6 P52701 Y845N 845 Y N 0.408 Neutral MSH6 P52701 Y845P 845 Y P 0.354 Neutral MSH6 P52701 Y845Q 845 Y Q 0.118 Neutral MSH6 P52701 Y845R 845 Y R 0.546 Pathogenic MSH6 P52701 Y845S 845 Y S 0.366 Neutral MSH6 P52701 Y845T 845 Y T 0.314 Neutral MSH6 P52701 Y845V 845 Y V 0.082 Neutral MSH6 P52701 Y845W 845 Y W 0.41 Neutral MSH6 P52701 E846A 846 E A 0.542 Pathogenic MSH6 P52701 E846C 846 E C 0.364 Neutral MSH6 P52701 E846D 846 E D 0.03 Neutral MSH6 P52701 E846F 846 E F 0.834 Pathogenic MSH6 P52701 E846G 846 E G 0.174 Neutral MSH6 P52701 E846H 846 E H 0.592 Pathogenic MSH6 P52701 E846I 846 E I 0.902 Pathogenic MSH6 P52701 E846K 846 E K 0.062 Neutral MSH6 P52701 E846L 846 E L 0.814 Pathogenic MSH6 P52701 E846M 846 E M 0.67 Pathogenic MSH6 P52701 E846N 846 E N 0.028 Neutral MSH6 P52701 E846P 846 E P 0.862 Pathogenic MSH6 P52701 E846Q 846 E Q 0.084 Neutral MSH6 P52701 E846R 846 E R 0.532 Pathogenic MSH6 P52701 E846S 846 E S 0.08 Neutral MSH6 P52701 E846T 846 E T 0.592 Pathogenic MSH6 P52701 E846V 846 E V 0.744 Pathogenic MSH6 P52701 E846W 846 E W 0.968 Pathogenic MSH6 P52701 E846Y 846 E Y 0.906 Pathogenic MSH6 P52701 E847A 847 E A 0.104 Neutral MSH6 P52701 E847C 847 E C 0.126 Neutral MSH6 P52701 E847D 847 E D 0.002 Neutral MSH6 P52701 E847F 847 E F 0.438 Neutral MSH6 P52701 E847G 847 E G 0 Neutral MSH6 P52701 E847H 847 E H 0.174 Neutral MSH6 P52701 E847I 847 E I 0.474 Neutral MSH6 P52701 E847K 847 E K 0.002 Neutral MSH6 P52701 E847L 847 E L 0.246 Neutral MSH6 P52701 E847M 847 E M 0.298 Neutral MSH6 P52701 E847N 847 E N 0.002 Neutral MSH6 P52701 E847P 847 E P 0.122 Neutral MSH6 P52701 E847Q 847 E Q 0.09 Neutral MSH6 P52701 E847R 847 E R 0.104 Neutral MSH6 P52701 E847S 847 E S 0.018 Neutral MSH6 P52701 E847T 847 E T 0.014 Neutral MSH6 P52701 E847V 847 E V 0.416 Neutral MSH6 P52701 E847W 847 E W 0.716 Pathogenic MSH6 P52701 E847Y 847 E Y 0.594 Pathogenic MSH6 P52701 T848A 848 T A 0 Neutral MSH6 P52701 T848C 848 T C 0.12 Neutral MSH6 P52701 T848D 848 T D 0.028 Neutral MSH6 P52701 T848E 848 T E 0.054 Neutral MSH6 P52701 T848F 848 T F 0.428 Neutral MSH6 P52701 T848G 848 T G 0.056 Neutral MSH6 P52701 T848H 848 T H 0.134 Neutral MSH6 P52701 T848I 848 T I 0.048 Neutral MSH6 P52701 T848K 848 T K 0.01 Neutral MSH6 P52701 T848L 848 T L 0.02 Neutral MSH6 P52701 T848M 848 T M 0.08 Neutral MSH6 P52701 T848N 848 T N 0.018 Neutral MSH6 P52701 T848P 848 T P 0.024 Neutral MSH6 P52701 T848Q 848 T Q 0.004 Neutral MSH6 P52701 T848R 848 T R 0.446 Neutral MSH6 P52701 T848S 848 T S 0 Neutral MSH6 P52701 T848V 848 T V 0.026 Neutral MSH6 P52701 T848W 848 T W 0.72 Pathogenic MSH6 P52701 T848Y 848 T Y 0.68 Pathogenic MSH6 P52701 T849A 849 T A 0 Neutral MSH6 P52701 T849C 849 T C 0.122 Neutral MSH6 P52701 T849D 849 T D 0.116 Neutral MSH6 P52701 T849E 849 T E 0.176 Neutral MSH6 P52701 T849F 849 T F 0.456 Neutral MSH6 P52701 T849G 849 T G 0.104 Neutral MSH6 P52701 T849H 849 T H 0.23 Neutral MSH6 P52701 T849I 849 T I 0.05 Neutral MSH6 P52701 T849K 849 T K 0.012 Neutral MSH6 P52701 T849L 849 T L 0.024 Neutral MSH6 P52701 T849M 849 T M 0.29 Neutral MSH6 P52701 T849N 849 T N 0 Neutral MSH6 P52701 T849P 849 T P 0.242 Neutral MSH6 P52701 T849Q 849 T Q 0.004 Neutral MSH6 P52701 T849R 849 T R 0.274 Neutral MSH6 P52701 T849S 849 T S 0.06 Neutral MSH6 P52701 T849V 849 T V 0.02 Neutral MSH6 P52701 T849W 849 T W 0.756 Pathogenic MSH6 P52701 T849Y 849 T Y 0.716 Pathogenic MSH6 P52701 P85A 85 P A 0.032 Neutral MSH6 P52701 P85C 85 P C 0.148 Neutral MSH6 P52701 P85D 85 P D 0.028 Neutral MSH6 P52701 P85E 85 P E 0.106 Neutral MSH6 P52701 P85F 85 P F 0.272 Neutral MSH6 P52701 P85G 85 P G 0.07 Neutral MSH6 P52701 P85H 85 P H 0.266 Neutral MSH6 P52701 P85I 85 P I 0.1 Neutral MSH6 P52701 P85K 85 P K 0.206 Neutral MSH6 P52701 P85L 85 P L 0.094 Neutral MSH6 P52701 P85M 85 P M 0.22 Neutral MSH6 P52701 P85N 85 P N 0.048 Neutral MSH6 P52701 P85Q 85 P Q 0.212 Neutral MSH6 P52701 P85R 85 P R 0.214 Neutral MSH6 P52701 P85S 85 P S 0.002 Neutral MSH6 P52701 P85T 85 P T 0.188 Neutral MSH6 P52701 P85V 85 P V 0.14 Neutral MSH6 P52701 P85W 85 P W 0.39 Neutral MSH6 P52701 P85Y 85 P Y 0.27 Neutral MSH6 P52701 Y850A 850 Y A 0.216 Neutral MSH6 P52701 Y850C 850 Y C 0.324 Neutral MSH6 P52701 Y850D 850 Y D 0.576 Pathogenic MSH6 P52701 Y850E 850 Y E 0.564 Pathogenic MSH6 P52701 Y850F 850 Y F 0.064 Neutral MSH6 P52701 Y850G 850 Y G 0.26 Neutral MSH6 P52701 Y850H 850 Y H 0.108 Neutral MSH6 P52701 Y850I 850 Y I 0.474 Neutral MSH6 P52701 Y850K 850 Y K 0.554 Pathogenic MSH6 P52701 Y850L 850 Y L 0.056 Neutral MSH6 P52701 Y850M 850 Y M 0.324 Neutral MSH6 P52701 Y850N 850 Y N 0.392 Neutral MSH6 P52701 Y850P 850 Y P 0.246 Neutral MSH6 P52701 Y850Q 850 Y Q 0.292 Neutral MSH6 P52701 Y850R 850 Y R 0.594 Pathogenic MSH6 P52701 Y850S 850 Y S 0.266 Neutral MSH6 P52701 Y850T 850 Y T 0.156 Neutral MSH6 P52701 Y850V 850 Y V 0.412 Neutral MSH6 P52701 Y850W 850 Y W 0.526 Pathogenic MSH6 P52701 S851A 851 S A 0.488 Neutral MSH6 P52701 S851C 851 S C 0.432 Neutral MSH6 P52701 S851D 851 S D 0.38 Neutral MSH6 P52701 S851E 851 S E 0.694 Pathogenic MSH6 P52701 S851F 851 S F 0.794 Pathogenic MSH6 P52701 S851G 851 S G 0.142 Neutral MSH6 P52701 S851H 851 S H 0.766 Pathogenic MSH6 P52701 S851I 851 S I 0.564 Pathogenic MSH6 P52701 S851K 851 S K 0.704 Pathogenic MSH6 P52701 S851L 851 S L 0.576 Pathogenic MSH6 P52701 S851M 851 S M 0.956 Pathogenic MSH6 P52701 S851N 851 S N 0.064 Neutral MSH6 P52701 S851P 851 S P 0.586 Pathogenic MSH6 P52701 S851Q 851 S Q 0.654 Pathogenic MSH6 P52701 S851R 851 S R 0.678 Pathogenic MSH6 P52701 S851T 851 S T 0.202 Neutral MSH6 P52701 S851V 851 S V 0.776 Pathogenic MSH6 P52701 S851W 851 S W 0.94 Pathogenic MSH6 P52701 S851Y 851 S Y 0.668 Pathogenic MSH6 P52701 K852A 852 K A 0.212 Neutral MSH6 P52701 K852C 852 K C 0.166 Neutral MSH6 P52701 K852D 852 K D 0.264 Neutral MSH6 P52701 K852E 852 K E 0.016 Neutral MSH6 P52701 K852F 852 K F 0.804 Pathogenic MSH6 P52701 K852G 852 K G 0.326 Neutral MSH6 P52701 K852H 852 K H 0.328 Neutral MSH6 P52701 K852I 852 K I 0.124 Neutral MSH6 P52701 K852L 852 K L 0.684 Pathogenic MSH6 P52701 K852M 852 K M 0.61 Pathogenic MSH6 P52701 K852N 852 K N 0.162 Neutral MSH6 P52701 K852P 852 K P 0.796 Pathogenic MSH6 P52701 K852Q 852 K Q 0.034 Neutral MSH6 P52701 K852R 852 K R 0.03 Neutral MSH6 P52701 K852S 852 K S 0.444 Neutral MSH6 P52701 K852T 852 K T 0.278 Neutral MSH6 P52701 K852V 852 K V 0.136 Neutral MSH6 P52701 K852W 852 K W 0.976 Pathogenic MSH6 P52701 K852Y 852 K Y 0.92 Pathogenic MSH6 P52701 K853A 853 K A 0.226 Neutral MSH6 P52701 K853C 853 K C 0.214 Neutral MSH6 P52701 K853D 853 K D 0.25 Neutral MSH6 P52701 K853E 853 K E 0.28 Neutral MSH6 P52701 K853F 853 K F 0.75 Pathogenic MSH6 P52701 K853G 853 K G 0.368 Neutral MSH6 P52701 K853H 853 K H 0.208 Neutral MSH6 P52701 K853I 853 K I 0.758 Pathogenic MSH6 P52701 K853L 853 K L 0.69 Pathogenic MSH6 P52701 K853M 853 K M 0.56 Pathogenic MSH6 P52701 K853N 853 K N 0.228 Neutral MSH6 P52701 K853P 853 K P 0.78 Pathogenic MSH6 P52701 K853Q 853 K Q 0.028 Neutral MSH6 P52701 K853R 853 K R 0.026 Neutral MSH6 P52701 K853S 853 K S 0.488 Neutral MSH6 P52701 K853T 853 K T 0.334 Neutral MSH6 P52701 K853V 853 K V 0.71 Pathogenic MSH6 P52701 K853W 853 K W 0.932 Pathogenic MSH6 P52701 K853Y 853 K Y 0.868 Pathogenic MSH6 P52701 K854A 854 K A 0.214 Neutral MSH6 P52701 K854C 854 K C 0.172 Neutral MSH6 P52701 K854D 854 K D 0.24 Neutral MSH6 P52701 K854E 854 K E 0.276 Neutral MSH6 P52701 K854F 854 K F 0.774 Pathogenic MSH6 P52701 K854G 854 K G 0.322 Neutral MSH6 P52701 K854H 854 K H 0.28 Neutral MSH6 P52701 K854I 854 K I 0.772 Pathogenic MSH6 P52701 K854L 854 K L 0.128 Neutral MSH6 P52701 K854M 854 K M 0.586 Pathogenic MSH6 P52701 K854N 854 K N 0.198 Neutral MSH6 P52701 K854P 854 K P 0.794 Pathogenic MSH6 P52701 K854Q 854 K Q 0.04 Neutral MSH6 P52701 K854R 854 K R 0.032 Neutral MSH6 P52701 K854S 854 K S 0.516 Pathogenic MSH6 P52701 K854T 854 K T 0.44 Neutral MSH6 P52701 K854V 854 K V 0.248 Neutral MSH6 P52701 K854W 854 K W 0.95 Pathogenic MSH6 P52701 K854Y 854 K Y 0.888 Pathogenic MSH6 P52701 I855A 855 I A 0.05 Neutral MSH6 P52701 I855C 855 I C 0.41 Neutral MSH6 P52701 I855D 855 I D 0.612 Pathogenic MSH6 P52701 I855E 855 I E 0.592 Pathogenic MSH6 P52701 I855F 855 I F 0.708 Pathogenic MSH6 P52701 I855G 855 I G 0.586 Pathogenic MSH6 P52701 I855H 855 I H 0.47 Neutral MSH6 P52701 I855K 855 I K 0.606 Pathogenic MSH6 P52701 I855L 855 I L 0.006 Neutral MSH6 P52701 I855M 855 I M 0.402 Neutral MSH6 P52701 I855N 855 I N 0.656 Pathogenic MSH6 P52701 I855P 855 I P 0.122 Neutral MSH6 P52701 I855Q 855 I Q 0.628 Pathogenic MSH6 P52701 I855R 855 I R 0.778 Pathogenic MSH6 P52701 I855S 855 I S 0.436 Neutral MSH6 P52701 I855T 855 I T 0.406 Neutral MSH6 P52701 I855V 855 I V 0.012 Neutral MSH6 P52701 I855W 855 I W 0.904 Pathogenic MSH6 P52701 I855Y 855 I Y 0.904 Pathogenic MSH6 P52701 I856A 856 I A 0.016 Neutral MSH6 P52701 I856C 856 I C 0.14 Neutral MSH6 P52701 I856D 856 I D 0.218 Neutral MSH6 P52701 I856E 856 I E 0.044 Neutral MSH6 P52701 I856F 856 I F 0.342 Neutral MSH6 P52701 I856G 856 I G 0.12 Neutral MSH6 P52701 I856H 856 I H 0.098 Neutral MSH6 P52701 I856K 856 I K 0.056 Neutral MSH6 P52701 I856L 856 I L 0.004 Neutral MSH6 P52701 I856M 856 I M 0.104 Neutral MSH6 P52701 I856N 856 I N 0.188 Neutral MSH6 P52701 I856P 856 I P 0.252 Neutral MSH6 P52701 I856Q 856 I Q 0.11 Neutral MSH6 P52701 I856R 856 I R 0.348 Neutral MSH6 P52701 I856S 856 I S 0.082 Neutral MSH6 P52701 I856T 856 I T 0.012 Neutral MSH6 P52701 I856V 856 I V 0.006 Neutral MSH6 P52701 I856W 856 I W 0.538 Pathogenic MSH6 P52701 I856Y 856 I Y 0.442 Neutral MSH6 P52701 D857A 857 D A 0.67 Pathogenic MSH6 P52701 D857C 857 D C 0.896 Pathogenic MSH6 P52701 D857E 857 D E 0.208 Neutral MSH6 P52701 D857F 857 D F 0.982 Pathogenic MSH6 P52701 D857G 857 D G 0.182 Neutral MSH6 P52701 D857H 857 D H 0.6 Pathogenic MSH6 P52701 D857I 857 D I 0.972 Pathogenic MSH6 P52701 D857K 857 D K 0.962 Pathogenic MSH6 P52701 D857L 857 D L 0.978 Pathogenic MSH6 P52701 D857M 857 D M 0.934 Pathogenic MSH6 P52701 D857N 857 D N 0.082 Neutral MSH6 P52701 D857P 857 D P 0.91 Pathogenic MSH6 P52701 D857Q 857 D Q 0.154 Neutral MSH6 P52701 D857R 857 D R 0.628 Pathogenic MSH6 P52701 D857S 857 D S 0.114 Neutral MSH6 P52701 D857T 857 D T 0.454 Neutral MSH6 P52701 D857V 857 D V 0.99 Pathogenic MSH6 P52701 D857W 857 D W 0.986 Pathogenic MSH6 P52701 D857Y 857 D Y 0.98 Pathogenic MSH6 P52701 F858A 858 F A 0.496 Neutral MSH6 P52701 F858C 858 F C 0.716 Pathogenic MSH6 P52701 F858D 858 F D 0.794 Pathogenic MSH6 P52701 F858E 858 F E 0.838 Pathogenic MSH6 P52701 F858G 858 F G 0.5 Pathogenic MSH6 P52701 F858H 858 F H 0.748 Pathogenic MSH6 P52701 F858I 858 F I 0.666 Pathogenic MSH6 P52701 F858K 858 F K 0.816 Pathogenic MSH6 P52701 F858L 858 F L 0.176 Neutral MSH6 P52701 F858M 858 F M 0.768 Pathogenic MSH6 P52701 F858N 858 F N 0.738 Pathogenic MSH6 P52701 F858P 858 F P 0.944 Pathogenic MSH6 P52701 F858Q 858 F Q 0.474 Neutral MSH6 P52701 F858R 858 F R 0.886 Pathogenic MSH6 P52701 F858S 858 F S 0.852 Pathogenic MSH6 P52701 F858T 858 F T 0.548 Pathogenic MSH6 P52701 F858V 858 F V 0.696 Pathogenic MSH6 P52701 F858W 858 F W 0.832 Pathogenic MSH6 P52701 F858Y 858 F Y 0.504 Pathogenic MSH6 P52701 L859A 859 L A 0.318 Neutral MSH6 P52701 L859C 859 L C 0.11 Neutral MSH6 P52701 L859D 859 L D 0.674 Pathogenic MSH6 P52701 L859E 859 L E 0.63 Pathogenic MSH6 P52701 L859F 859 L F 0.708 Pathogenic MSH6 P52701 L859G 859 L G 0.578 Pathogenic MSH6 P52701 L859H 859 L H 0.432 Neutral MSH6 P52701 L859I 859 L I 0.038 Neutral MSH6 P52701 L859K 859 L K 0.468 Neutral MSH6 P52701 L859M 859 L M 0.02 Neutral MSH6 P52701 L859N 859 L N 0.618 Pathogenic MSH6 P52701 L859P 859 L P 0.93 Pathogenic MSH6 P52701 L859Q 859 L Q 0.192 Neutral MSH6 P52701 L859R 859 L R 0.74 Pathogenic MSH6 P52701 L859S 859 L S 0.04 Neutral MSH6 P52701 L859T 859 L T 0.032 Neutral MSH6 P52701 L859V 859 L V 0.002 Neutral MSH6 P52701 L859W 859 L W 0.832 Pathogenic MSH6 P52701 L859Y 859 L Y 0.82 Pathogenic MSH6 P52701 T86A 86 T A 0.06 Neutral MSH6 P52701 T86C 86 T C 0.064 Neutral MSH6 P52701 T86D 86 T D 0.046 Neutral MSH6 P52701 T86E 86 T E 0.04 Neutral MSH6 P52701 T86F 86 T F 0.214 Neutral MSH6 P52701 T86G 86 T G 0.036 Neutral MSH6 P52701 T86H 86 T H 0.084 Neutral MSH6 P52701 T86I 86 T I 0.066 Neutral MSH6 P52701 T86K 86 T K 0.026 Neutral MSH6 P52701 T86L 86 T L 0.07 Neutral MSH6 P52701 T86M 86 T M 0.098 Neutral MSH6 P52701 T86N 86 T N 0.052 Neutral MSH6 P52701 T86P 86 T P 0.084 Neutral MSH6 P52701 T86Q 86 T Q 0 Neutral MSH6 P52701 T86R 86 T R 0.26 Neutral MSH6 P52701 T86S 86 T S 0 Neutral MSH6 P52701 T86V 86 T V 0.016 Neutral MSH6 P52701 T86W 86 T W 0.466 Neutral MSH6 P52701 T86Y 86 T Y 0.424 Neutral MSH6 P52701 S860A 860 S A 0.04 Neutral MSH6 P52701 S860C 860 S C 0.342 Neutral MSH6 P52701 S860D 860 S D 0.494 Neutral MSH6 P52701 S860E 860 S E 0.736 Pathogenic MSH6 P52701 S860F 860 S F 0.884 Pathogenic MSH6 P52701 S860G 860 S G 0.234 Neutral MSH6 P52701 S860H 860 S H 0.674 Pathogenic MSH6 P52701 S860I 860 S I 0.592 Pathogenic MSH6 P52701 S860K 860 S K 0.444 Neutral MSH6 P52701 S860L 860 S L 0.164 Neutral MSH6 P52701 S860M 860 S M 0.896 Pathogenic MSH6 P52701 S860N 860 S N 0.066 Neutral MSH6 P52701 S860P 860 S P 0.602 Pathogenic MSH6 P52701 S860Q 860 S Q 0.468 Neutral MSH6 P52701 S860R 860 S R 0.47 Neutral MSH6 P52701 S860T 860 S T 0.06 Neutral MSH6 P52701 S860V 860 S V 0.786 Pathogenic MSH6 P52701 S860W 860 S W 0.93 Pathogenic MSH6 P52701 S860Y 860 S Y 0.932 Pathogenic MSH6 P52701 A861C 861 A C 0.792 Pathogenic MSH6 P52701 A861D 861 A D 0.824 Pathogenic MSH6 P52701 A861E 861 A E 0.864 Pathogenic MSH6 P52701 A861F 861 A F 0.928 Pathogenic MSH6 P52701 A861G 861 A G 0.642 Pathogenic MSH6 P52701 A861H 861 A H 0.822 Pathogenic MSH6 P52701 A861I 861 A I 0.726 Pathogenic MSH6 P52701 A861K 861 A K 0.884 Pathogenic MSH6 P52701 A861L 861 A L 0.704 Pathogenic MSH6 P52701 A861M 861 A M 0.77 Pathogenic MSH6 P52701 A861N 861 A N 0.658 Pathogenic MSH6 P52701 A861P 861 A P 0.906 Pathogenic MSH6 P52701 A861Q 861 A Q 0.84 Pathogenic MSH6 P52701 A861R 861 A R 0.88 Pathogenic MSH6 P52701 A861S 861 A S 0.356 Neutral MSH6 P52701 A861T 861 A T 0.18 Neutral MSH6 P52701 A861V 861 A V 0.44 Neutral MSH6 P52701 A861W 861 A W 0.928 Pathogenic MSH6 P52701 A861Y 861 A Y 0.902 Pathogenic MSH6 P52701 L862A 862 L A 0.322 Neutral MSH6 P52701 L862C 862 L C 0.806 Pathogenic MSH6 P52701 L862D 862 L D 0.884 Pathogenic MSH6 P52701 L862E 862 L E 0.866 Pathogenic MSH6 P52701 L862F 862 L F 0.666 Pathogenic MSH6 P52701 L862G 862 L G 0.858 Pathogenic MSH6 P52701 L862H 862 L H 0.898 Pathogenic MSH6 P52701 L862I 862 L I 0.278 Neutral MSH6 P52701 L862K 862 L K 0.69 Pathogenic MSH6 P52701 L862M 862 L M 0.564 Pathogenic MSH6 P52701 L862N 862 L N 0.796 Pathogenic MSH6 P52701 L862P 862 L P 0.966 Pathogenic MSH6 P52701 L862Q 862 L Q 0.756 Pathogenic MSH6 P52701 L862R 862 L R 0.974 Pathogenic MSH6 P52701 L862S 862 L S 0.682 Pathogenic MSH6 P52701 L862T 862 L T 0.6 Pathogenic MSH6 P52701 L862V 862 L V 0.154 Neutral MSH6 P52701 L862W 862 L W 0.846 Pathogenic MSH6 P52701 L862Y 862 L Y 0.868 Pathogenic MSH6 P52701 E863A 863 E A 0.23 Neutral MSH6 P52701 E863C 863 E C 0.344 Neutral MSH6 P52701 E863D 863 E D 0.016 Neutral MSH6 P52701 E863F 863 E F 0.858 Pathogenic MSH6 P52701 E863G 863 E G 0.05 Neutral MSH6 P52701 E863H 863 E H 0.08 Neutral MSH6 P52701 E863I 863 E I 0.916 Pathogenic MSH6 P52701 E863K 863 E K 0.042 Neutral MSH6 P52701 E863L 863 E L 0.894 Pathogenic MSH6 P52701 E863M 863 E M 0.7 Pathogenic MSH6 P52701 E863N 863 E N 0.012 Neutral MSH6 P52701 E863P 863 E P 0.878 Pathogenic MSH6 P52701 E863Q 863 E Q 0.07 Neutral MSH6 P52701 E863R 863 E R 0.118 Neutral MSH6 P52701 E863S 863 E S 0.08 Neutral MSH6 P52701 E863T 863 E T 0.064 Neutral MSH6 P52701 E863V 863 E V 0.446 Neutral MSH6 P52701 E863W 863 E W 0.968 Pathogenic MSH6 P52701 E863Y 863 E Y 0.914 Pathogenic MSH6 P52701 G864A 864 G A 0.358 Neutral MSH6 P52701 G864C 864 G C 0.676 Pathogenic MSH6 P52701 G864D 864 G D 0.996 Pathogenic MSH6 P52701 G864E 864 G E 0.978 Pathogenic MSH6 P52701 G864F 864 G F 0.974 Pathogenic MSH6 P52701 G864H 864 G H 0.704 Pathogenic MSH6 P52701 G864I 864 G I 0.966 Pathogenic MSH6 P52701 G864K 864 G K 0.674 Pathogenic MSH6 P52701 G864L 864 G L 0.976 Pathogenic MSH6 P52701 G864M 864 G M 0.99 Pathogenic MSH6 P52701 G864N 864 G N 0.572 Pathogenic MSH6 P52701 G864P 864 G P 0.942 Pathogenic MSH6 P52701 G864Q 864 G Q 0.988 Pathogenic MSH6 P52701 G864R 864 G R 0.862 Pathogenic MSH6 P52701 G864S 864 G S 0.336 Neutral MSH6 P52701 G864T 864 G T 0.706 Pathogenic MSH6 P52701 G864V 864 G V 0.978 Pathogenic MSH6 P52701 G864W 864 G W 0.97 Pathogenic MSH6 P52701 G864Y 864 G Y 0.936 Pathogenic MSH6 P52701 F865A 865 F A 0.506 Pathogenic MSH6 P52701 F865C 865 F C 0.166 Neutral MSH6 P52701 F865D 865 F D 0.794 Pathogenic MSH6 P52701 F865E 865 F E 0.854 Pathogenic MSH6 P52701 F865G 865 F G 0.488 Neutral MSH6 P52701 F865H 865 F H 0.758 Pathogenic MSH6 P52701 F865I 865 F I 0.668 Pathogenic MSH6 P52701 F865K 865 F K 0.838 Pathogenic MSH6 P52701 F865L 865 F L 0.154 Neutral MSH6 P52701 F865M 865 F M 0.776 Pathogenic MSH6 P52701 F865N 865 F N 0.71 Pathogenic MSH6 P52701 F865P 865 F P 0.954 Pathogenic MSH6 P52701 F865Q 865 F Q 0.73 Pathogenic MSH6 P52701 F865R 865 F R 0.912 Pathogenic MSH6 P52701 F865S 865 F S 0.816 Pathogenic MSH6 P52701 F865T 865 F T 0.598 Pathogenic MSH6 P52701 F865V 865 F V 0.856 Pathogenic MSH6 P52701 F865W 865 F W 0.928 Pathogenic MSH6 P52701 F865Y 865 F Y 0.27 Neutral MSH6 P52701 K866A 866 K A 0.088 Neutral MSH6 P52701 K866C 866 K C 0.196 Neutral MSH6 P52701 K866D 866 K D 0.016 Neutral MSH6 P52701 K866E 866 K E 0.022 Neutral MSH6 P52701 K866F 866 K F 0.848 Pathogenic MSH6 P52701 K866G 866 K G 0.304 Neutral MSH6 P52701 K866H 866 K H 0.396 Neutral MSH6 P52701 K866I 866 K I 0.896 Pathogenic MSH6 P52701 K866L 866 K L 0.86 Pathogenic MSH6 P52701 K866M 866 K M 0.658 Pathogenic MSH6 P52701 K866N 866 K N 0.104 Neutral MSH6 P52701 K866P 866 K P 0.834 Pathogenic MSH6 P52701 K866Q 866 K Q 0.028 Neutral MSH6 P52701 K866R 866 K R 0.036 Neutral MSH6 P52701 K866S 866 K S 0.438 Neutral MSH6 P52701 K866T 866 K T 0.278 Neutral MSH6 P52701 K866V 866 K V 0.782 Pathogenic MSH6 P52701 K866W 866 K W 0.924 Pathogenic MSH6 P52701 K866Y 866 K Y 0.932 Pathogenic MSH6 P52701 V867A 867 V A 0.006 Neutral MSH6 P52701 V867C 867 V C 0.19 Neutral MSH6 P52701 V867D 867 V D 0.052 Neutral MSH6 P52701 V867E 867 V E 0.076 Neutral MSH6 P52701 V867F 867 V F 0.482 Neutral MSH6 P52701 V867G 867 V G 0.468 Neutral MSH6 P52701 V867H 867 V H 0.1 Neutral MSH6 P52701 V867I 867 V I 0.014 Neutral MSH6 P52701 V867K 867 V K 0.102 Neutral MSH6 P52701 V867L 867 V L 0.124 Neutral MSH6 P52701 V867M 867 V M 0.244 Neutral MSH6 P52701 V867N 867 V N 0.066 Neutral MSH6 P52701 V867P 867 V P 0.506 Pathogenic MSH6 P52701 V867Q 867 V Q 0.094 Neutral MSH6 P52701 V867R 867 V R 0.418 Neutral MSH6 P52701 V867S 867 V S 0.024 Neutral MSH6 P52701 V867T 867 V T 0.01 Neutral MSH6 P52701 V867W 867 V W 0.648 Pathogenic MSH6 P52701 V867Y 867 V Y 0.398 Neutral MSH6 P52701 M868A 868 M A 0.138 Neutral MSH6 P52701 M868C 868 M C 0.08 Neutral MSH6 P52701 M868D 868 M D 0.61 Pathogenic MSH6 P52701 M868E 868 M E 0.368 Neutral MSH6 P52701 M868F 868 M F 0.106 Neutral MSH6 P52701 M868G 868 M G 0.112 Neutral MSH6 P52701 M868H 868 M H 0.42 Neutral MSH6 P52701 M868I 868 M I 0.072 Neutral MSH6 P52701 M868K 868 M K 0.616 Pathogenic MSH6 P52701 M868L 868 M L 0.062 Neutral MSH6 P52701 M868N 868 M N 0.63 Pathogenic MSH6 P52701 M868P 868 M P 0.86 Pathogenic MSH6 P52701 M868Q 868 M Q 0.298 Neutral MSH6 P52701 M868R 868 M R 0.64 Pathogenic MSH6 P52701 M868S 868 M S 0.09 Neutral MSH6 P52701 M868T 868 M T 0.038 Neutral MSH6 P52701 M868V 868 M V 0.068 Neutral MSH6 P52701 M868W 868 M W 0.96 Pathogenic MSH6 P52701 M868Y 868 M Y 0.866 Pathogenic MSH6 P52701 C869A 869 C A 0.014 Neutral MSH6 P52701 C869D 869 C D 0.014 Neutral MSH6 P52701 C869E 869 C E 0.038 Neutral MSH6 P52701 C869F 869 C F 0.67 Pathogenic MSH6 P52701 C869G 869 C G 0.238 Neutral MSH6 P52701 C869H 869 C H 0.152 Neutral MSH6 P52701 C869I 869 C I 0.104 Neutral MSH6 P52701 C869K 869 C K 0.384 Neutral MSH6 P52701 C869L 869 C L 0.04 Neutral MSH6 P52701 C869M 869 C M 0.036 Neutral MSH6 P52701 C869N 869 C N 0 Neutral MSH6 P52701 C869P 869 C P 0.062 Neutral MSH6 P52701 C869Q 869 C Q 0.008 Neutral MSH6 P52701 C869R 869 C R 0.306 Neutral MSH6 P52701 C869S 869 C S 0.016 Neutral MSH6 P52701 C869T 869 C T 0 Neutral MSH6 P52701 C869V 869 C V 0.02 Neutral MSH6 P52701 C869W 869 C W 0.75 Pathogenic MSH6 P52701 C869Y 869 C Y 0.458 Neutral MSH6 P52701 S87A 87 S A 0.01 Neutral MSH6 P52701 S87C 87 S C 0.022 Neutral MSH6 P52701 S87D 87 S D 0.024 Neutral MSH6 P52701 S87E 87 S E 0.148 Neutral MSH6 P52701 S87F 87 S F 0.266 Neutral MSH6 P52701 S87G 87 S G 0.064 Neutral MSH6 P52701 S87H 87 S H 0.238 Neutral MSH6 P52701 S87I 87 S I 0.026 Neutral MSH6 P52701 S87K 87 S K 0.14 Neutral MSH6 P52701 S87L 87 S L 0.028 Neutral MSH6 P52701 S87M 87 S M 0.332 Neutral MSH6 P52701 S87N 87 S N 0.034 Neutral MSH6 P52701 S87P 87 S P 0.132 Neutral MSH6 P52701 S87Q 87 S Q 0.158 Neutral MSH6 P52701 S87R 87 S R 0.248 Neutral MSH6 P52701 S87T 87 S T 0.176 Neutral MSH6 P52701 S87V 87 S V 0.248 Neutral MSH6 P52701 S87W 87 S W 0.49 Neutral MSH6 P52701 S87Y 87 S Y 0.448 Neutral MSH6 P52701 K870A 870 K A 0.114 Neutral MSH6 P52701 K870C 870 K C 0.166 Neutral MSH6 P52701 K870D 870 K D 0.014 Neutral MSH6 P52701 K870E 870 K E 0.012 Neutral MSH6 P52701 K870F 870 K F 0.716 Pathogenic MSH6 P52701 K870G 870 K G 0.134 Neutral MSH6 P52701 K870H 870 K H 0.008 Neutral MSH6 P52701 K870I 870 K I 0.74 Pathogenic MSH6 P52701 K870L 870 K L 0.082 Neutral MSH6 P52701 K870M 870 K M 0.522 Pathogenic MSH6 P52701 K870N 870 K N 0.026 Neutral MSH6 P52701 K870P 870 K P 0.722 Pathogenic MSH6 P52701 K870Q 870 K Q 0.024 Neutral MSH6 P52701 K870R 870 K R 0.016 Neutral MSH6 P52701 K870S 870 K S 0.03 Neutral MSH6 P52701 K870T 870 K T 0.038 Neutral MSH6 P52701 K870V 870 K V 0.66 Pathogenic MSH6 P52701 K870W 870 K W 0.906 Pathogenic MSH6 P52701 K870Y 870 K Y 0.266 Neutral MSH6 P52701 I871A 871 I A 0.052 Neutral MSH6 P52701 I871C 871 I C 0.256 Neutral MSH6 P52701 I871D 871 I D 0.57 Pathogenic MSH6 P52701 I871E 871 I E 0.1 Neutral MSH6 P52701 I871F 871 I F 0.132 Neutral MSH6 P52701 I871G 871 I G 0.422 Neutral MSH6 P52701 I871H 871 I H 0.39 Neutral MSH6 P52701 I871K 871 I K 0.312 Neutral MSH6 P52701 I871L 871 I L 0.006 Neutral MSH6 P52701 I871M 871 I M 0.492 Neutral MSH6 P52701 I871N 871 I N 0.402 Neutral MSH6 P52701 I871P 871 I P 0.644 Pathogenic MSH6 P52701 I871Q 871 I Q 0.646 Pathogenic MSH6 P52701 I871R 871 I R 0.784 Pathogenic MSH6 P52701 I871S 871 I S 0.1 Neutral MSH6 P52701 I871T 871 I T 0.03 Neutral MSH6 P52701 I871V 871 I V 0.01 Neutral MSH6 P52701 I871W 871 I W 0.814 Pathogenic MSH6 P52701 I871Y 871 I Y 0.832 Pathogenic MSH6 P52701 I872A 872 I A 0.012 Neutral MSH6 P52701 I872C 872 I C 0.124 Neutral MSH6 P52701 I872D 872 I D 0.212 Neutral MSH6 P52701 I872E 872 I E 0.2 Neutral MSH6 P52701 I872F 872 I F 0.096 Neutral MSH6 P52701 I872G 872 I G 0.21 Neutral MSH6 P52701 I872H 872 I H 0.106 Neutral MSH6 P52701 I872K 872 I K 0.208 Neutral MSH6 P52701 I872L 872 I L 0 Neutral MSH6 P52701 I872M 872 I M 0.232 Neutral MSH6 P52701 I872N 872 I N 0.254 Neutral MSH6 P52701 I872P 872 I P 0.26 Neutral MSH6 P52701 I872Q 872 I Q 0.252 Neutral MSH6 P52701 I872R 872 I R 0.344 Neutral MSH6 P52701 I872S 872 I S 0.318 Neutral MSH6 P52701 I872T 872 I T 0.106 Neutral MSH6 P52701 I872V 872 I V 0 Neutral MSH6 P52701 I872W 872 I W 0.53 Pathogenic MSH6 P52701 I872Y 872 I Y 0.502 Pathogenic MSH6 P52701 G873A 873 G A 0.002 Neutral MSH6 P52701 G873C 873 G C 0.144 Neutral MSH6 P52701 G873D 873 G D 0.136 Neutral MSH6 P52701 G873E 873 G E 0.196 Neutral MSH6 P52701 G873F 873 G F 0.504 Pathogenic MSH6 P52701 G873H 873 G H 0.46 Neutral MSH6 P52701 G873I 873 G I 0.428 Neutral MSH6 P52701 G873K 873 G K 0.29 Neutral MSH6 P52701 G873L 873 G L 0.382 Neutral MSH6 P52701 G873M 873 G M 0.274 Neutral MSH6 P52701 G873N 873 G N 0.178 Neutral MSH6 P52701 G873P 873 G P 0.456 Neutral MSH6 P52701 G873Q 873 G Q 0.19 Neutral MSH6 P52701 G873R 873 G R 0.31 Neutral MSH6 P52701 G873S 873 G S 0.012 Neutral MSH6 P52701 G873T 873 G T 0.29 Neutral MSH6 P52701 G873V 873 G V 0.42 Neutral MSH6 P52701 G873W 873 G W 0.514 Pathogenic MSH6 P52701 G873Y 873 G Y 0.498 Neutral MSH6 P52701 I874A 874 I A 0.006 Neutral MSH6 P52701 I874C 874 I C 0.09 Neutral MSH6 P52701 I874D 874 I D 0.088 Neutral MSH6 P52701 I874E 874 I E 0.032 Neutral MSH6 P52701 I874F 874 I F 0.07 Neutral MSH6 P52701 I874G 874 I G 0.23 Neutral MSH6 P52701 I874H 874 I H 0.046 Neutral MSH6 P52701 I874K 874 I K 0.044 Neutral MSH6 P52701 I874L 874 I L 0 Neutral MSH6 P52701 I874M 874 I M 0.018 Neutral MSH6 P52701 I874N 874 I N 0.096 Neutral MSH6 P52701 I874P 874 I P 0.066 Neutral MSH6 P52701 I874Q 874 I Q 0.138 Neutral MSH6 P52701 I874R 874 I R 0.26 Neutral MSH6 P52701 I874S 874 I S 0.072 Neutral MSH6 P52701 I874T 874 I T 0.002 Neutral MSH6 P52701 I874V 874 I V 0 Neutral MSH6 P52701 I874W 874 I W 0.344 Neutral MSH6 P52701 I874Y 874 I Y 0.298 Neutral MSH6 P52701 M875A 875 M A 0.078 Neutral MSH6 P52701 M875C 875 M C 0.016 Neutral MSH6 P52701 M875D 875 M D 0.24 Neutral MSH6 P52701 M875E 875 M E 0.114 Neutral MSH6 P52701 M875F 875 M F 0.034 Neutral MSH6 P52701 M875G 875 M G 0.172 Neutral MSH6 P52701 M875H 875 M H 0.102 Neutral MSH6 P52701 M875I 875 M I 0.016 Neutral MSH6 P52701 M875K 875 M K 0.124 Neutral MSH6 P52701 M875L 875 M L 0.014 Neutral MSH6 P52701 M875N 875 M N 0.168 Neutral MSH6 P52701 M875P 875 M P 0.428 Neutral MSH6 P52701 M875Q 875 M Q 0.038 Neutral MSH6 P52701 M875R 875 M R 0.06 Neutral MSH6 P52701 M875S 875 M S 0.084 Neutral MSH6 P52701 M875T 875 M T 0.288 Neutral MSH6 P52701 M875V 875 M V 0.028 Neutral MSH6 P52701 M875W 875 M W 0.656 Pathogenic MSH6 P52701 M875Y 875 M Y 0.15 Neutral MSH6 P52701 E876A 876 E A 0.076 Neutral MSH6 P52701 E876C 876 E C 0.11 Neutral MSH6 P52701 E876D 876 E D 0.014 Neutral MSH6 P52701 E876F 876 E F 0.08 Neutral MSH6 P52701 E876G 876 E G 0 Neutral MSH6 P52701 E876H 876 E H 0.176 Neutral MSH6 P52701 E876I 876 E I 0.138 Neutral MSH6 P52701 E876K 876 E K 0.002 Neutral MSH6 P52701 E876L 876 E L 0.058 Neutral MSH6 P52701 E876M 876 E M 0.03 Neutral MSH6 P52701 E876N 876 E N 0.054 Neutral MSH6 P52701 E876P 876 E P 0.062 Neutral MSH6 P52701 E876Q 876 E Q 0 Neutral MSH6 P52701 E876R 876 E R 0.034 Neutral MSH6 P52701 E876S 876 E S 0.02 Neutral MSH6 P52701 E876T 876 E T 0.016 Neutral MSH6 P52701 E876V 876 E V 0.044 Neutral MSH6 P52701 E876W 876 E W 0.708 Pathogenic MSH6 P52701 E876Y 876 E Y 0.66 Pathogenic MSH6 P52701 E877A 877 E A 0.104 Neutral MSH6 P52701 E877C 877 E C 0.124 Neutral MSH6 P52701 E877D 877 E D 0.002 Neutral MSH6 P52701 E877F 877 E F 0.438 Neutral MSH6 P52701 E877G 877 E G 0 Neutral MSH6 P52701 E877H 877 E H 0.288 Neutral MSH6 P52701 E877I 877 E I 0.216 Neutral MSH6 P52701 E877K 877 E K 0.002 Neutral MSH6 P52701 E877L 877 E L 0.068 Neutral MSH6 P52701 E877M 877 E M 0.34 Neutral MSH6 P52701 E877N 877 E N 0.002 Neutral MSH6 P52701 E877P 877 E P 0.072 Neutral MSH6 P52701 E877Q 877 E Q 0 Neutral MSH6 P52701 E877R 877 E R 0.094 Neutral MSH6 P52701 E877S 877 E S 0.024 Neutral MSH6 P52701 E877T 877 E T 0.018 Neutral MSH6 P52701 E877V 877 E V 0.108 Neutral MSH6 P52701 E877W 877 E W 0.714 Pathogenic MSH6 P52701 E877Y 877 E Y 0.59 Pathogenic MSH6 P52701 V878A 878 V A 0 Neutral 1 MSH6 P52701 V878C 878 V C 0.05 Neutral MSH6 P52701 V878D 878 V D 0.092 Neutral MSH6 P52701 V878E 878 V E 0.064 Neutral MSH6 P52701 V878F 878 V F 0.238 Neutral MSH6 P52701 V878G 878 V G 0.272 Neutral MSH6 P52701 V878H 878 V H 0.076 Neutral MSH6 P52701 V878I 878 V I 0.006 Neutral MSH6 P52701 V878K 878 V K 0.092 Neutral MSH6 P52701 V878L 878 V L 0.008 Neutral MSH6 P52701 V878M 878 V M 0.024 Neutral MSH6 P52701 V878N 878 V N 0.12 Neutral MSH6 P52701 V878P 878 V P 0.31 Neutral MSH6 P52701 V878Q 878 V Q 0.072 Neutral MSH6 P52701 V878R 878 V R 0.314 Neutral MSH6 P52701 V878S 878 V S 0.016 Neutral MSH6 P52701 V878T 878 V T 0.008 Neutral MSH6 P52701 V878W 878 V W 0.55 Pathogenic MSH6 P52701 V878Y 878 V Y 0.246 Neutral MSH6 P52701 A879C 879 A C 0.434 Neutral MSH6 P52701 A879D 879 A D 0.876 Pathogenic MSH6 P52701 A879E 879 A E 0.828 Pathogenic MSH6 P52701 A879F 879 A F 0.552 Pathogenic MSH6 P52701 A879G 879 A G 0.488 Neutral MSH6 P52701 A879H 879 A H 0.826 Pathogenic MSH6 P52701 A879I 879 A I 0.614 Pathogenic MSH6 P52701 A879K 879 A K 0.882 Pathogenic MSH6 P52701 A879L 879 A L 0.572 Pathogenic MSH6 P52701 A879M 879 A M 0.692 Pathogenic MSH6 P52701 A879N 879 A N 0.66 Pathogenic MSH6 P52701 A879P 879 A P 0.828 Pathogenic MSH6 P52701 A879Q 879 A Q 0.492 Neutral MSH6 P52701 A879R 879 A R 0.612 Pathogenic MSH6 P52701 A879S 879 A S 0.02 Neutral MSH6 P52701 A879T 879 A T 0.106 Neutral MSH6 P52701 A879V 879 A V 0.136 Neutral MSH6 P52701 A879W 879 A W 0.924 Pathogenic MSH6 P52701 A879Y 879 A Y 0.918 Pathogenic MSH6 P52701 C88A 88 C A 0.078 Neutral MSH6 P52701 C88D 88 C D 0.056 Neutral MSH6 P52701 C88E 88 C E 0.18 Neutral MSH6 P52701 C88F 88 C F 0.412 Neutral MSH6 P52701 C88G 88 C G 0.166 Neutral MSH6 P52701 C88H 88 C H 0.202 Neutral MSH6 P52701 C88I 88 C I 0.342 Neutral MSH6 P52701 C88K 88 C K 0.184 Neutral MSH6 P52701 C88L 88 C L 0.252 Neutral MSH6 P52701 C88M 88 C M 0.136 Neutral MSH6 P52701 C88N 88 C N 0.018 Neutral MSH6 P52701 C88P 88 C P 0.11 Neutral MSH6 P52701 C88Q 88 C Q 0.14 Neutral MSH6 P52701 C88R 88 C R 0.266 Neutral MSH6 P52701 C88S 88 C S 0.174 Neutral MSH6 P52701 C88T 88 C T 0.108 Neutral MSH6 P52701 C88V 88 C V 0.194 Neutral MSH6 P52701 C88W 88 C W 0.482 Neutral MSH6 P52701 C88Y 88 C Y 0.432 Neutral MSH6 P52701 D880A 880 D A 0.026 Neutral MSH6 P52701 D880C 880 D C 0.26 Neutral MSH6 P52701 D880E 880 D E 0.012 Neutral MSH6 P52701 D880F 880 D F 0.626 Pathogenic MSH6 P52701 D880G 880 D G 0.024 Neutral MSH6 P52701 D880H 880 D H 0.078 Neutral MSH6 P52701 D880I 880 D I 0.326 Neutral MSH6 P52701 D880K 880 D K 0.018 Neutral MSH6 P52701 D880L 880 D L 0.06 Neutral MSH6 P52701 D880M 880 D M 0.338 Neutral MSH6 P52701 D880N 880 D N 0 Neutral MSH6 P52701 D880P 880 D P 0.068 Neutral MSH6 P52701 D880Q 880 D Q 0.01 Neutral MSH6 P52701 D880R 880 D R 0.278 Neutral MSH6 P52701 D880S 880 D S 0.002 Neutral MSH6 P52701 D880T 880 D T 0.03 Neutral MSH6 P52701 D880V 880 D V 0.292 Neutral MSH6 P52701 D880W 880 D W 0.748 Pathogenic MSH6 P52701 D880Y 880 D Y 0.716 Pathogenic MSH6 P52701 G881A 881 G A 0.012 Neutral MSH6 P52701 G881C 881 G C 0.476 Neutral MSH6 P52701 G881D 881 G D 0.302 Neutral MSH6 P52701 G881E 881 G E 0.392 Neutral MSH6 P52701 G881F 881 G F 0.856 Pathogenic MSH6 P52701 G881H 881 G H 0.486 Neutral MSH6 P52701 G881I 881 G I 0.782 Pathogenic MSH6 P52701 G881K 881 G K 0.476 Neutral MSH6 P52701 G881L 881 G L 0.54 Pathogenic MSH6 P52701 G881M 881 G M 0.79 Pathogenic MSH6 P52701 G881N 881 G N 0.336 Neutral MSH6 P52701 G881P 881 G P 0.8 Pathogenic MSH6 P52701 G881Q 881 G Q 0.388 Neutral MSH6 P52701 G881R 881 G R 0.6 Pathogenic MSH6 P52701 G881S 881 G S 0.034 Neutral MSH6 P52701 G881T 881 G T 0.646 Pathogenic MSH6 P52701 G881V 881 G V 0.754 Pathogenic MSH6 P52701 G881W 881 G W 0.852 Pathogenic MSH6 P52701 G881Y 881 G Y 0.686 Pathogenic MSH6 P52701 F882A 882 F A 0.066 Neutral MSH6 P52701 F882C 882 F C 0.012 Neutral MSH6 P52701 F882D 882 F D 0.032 Neutral MSH6 P52701 F882E 882 F E 0.174 Neutral MSH6 P52701 F882G 882 F G 0.058 Neutral MSH6 P52701 F882H 882 F H 0.088 Neutral MSH6 P52701 F882I 882 F I 0.036 Neutral MSH6 P52701 F882K 882 F K 0.17 Neutral MSH6 P52701 F882L 882 F L 0.004 Neutral MSH6 P52701 F882M 882 F M 0.102 Neutral MSH6 P52701 F882N 882 F N 0.068 Neutral MSH6 P52701 F882P 882 F P 0.046 Neutral MSH6 P52701 F882Q 882 F Q 0.078 Neutral MSH6 P52701 F882R 882 F R 0.228 Neutral MSH6 P52701 F882S 882 F S 0.022 Neutral MSH6 P52701 F882T 882 F T 0.018 Neutral MSH6 P52701 F882V 882 F V 0.01 Neutral MSH6 P52701 F882W 882 F W 0.472 Neutral MSH6 P52701 F882Y 882 F Y 0.02 Neutral MSH6 P52701 K883A 883 K A 0.064 Neutral MSH6 P52701 K883C 883 K C 0.01 Neutral MSH6 P52701 K883D 883 K D 0.002 Neutral MSH6 P52701 K883E 883 K E 0.004 Neutral MSH6 P52701 K883F 883 K F 0.35 Neutral MSH6 P52701 K883G 883 K G 0.048 Neutral MSH6 P52701 K883H 883 K H 0 Neutral MSH6 P52701 K883I 883 K I 0.188 Neutral MSH6 P52701 K883L 883 K L 0.368 Neutral MSH6 P52701 K883M 883 K M 0.168 Neutral MSH6 P52701 K883N 883 K N 0.02 Neutral MSH6 P52701 K883P 883 K P 0.378 Neutral MSH6 P52701 K883Q 883 K Q 0.01 Neutral MSH6 P52701 K883R 883 K R 0.006 Neutral MSH6 P52701 K883S 883 K S 0.016 Neutral MSH6 P52701 K883T 883 K T 0.014 Neutral MSH6 P52701 K883V 883 K V 0.168 Neutral MSH6 P52701 K883W 883 K W 0.662 Pathogenic MSH6 P52701 K883Y 883 K Y 0.576 Pathogenic MSH6 P52701 S884A 884 S A 0.366 Neutral MSH6 P52701 S884C 884 S C 0.06 Neutral MSH6 P52701 S884D 884 S D 0.52 Pathogenic MSH6 P52701 S884E 884 S E 0.628 Pathogenic MSH6 P52701 S884F 884 S F 0.892 Pathogenic MSH6 P52701 S884G 884 S G 0.018 Neutral MSH6 P52701 S884H 884 S H 0.804 Pathogenic MSH6 P52701 S884I 884 S I 0.594 Pathogenic MSH6 P52701 S884K 884 S K 0.744 Pathogenic MSH6 P52701 S884L 884 S L 0.532 Pathogenic MSH6 P52701 S884M 884 S M 0.98 Pathogenic MSH6 P52701 S884N 884 S N 0.05 Neutral MSH6 P52701 S884P 884 S P 0.178 Neutral MSH6 P52701 S884Q 884 S Q 0.698 Pathogenic MSH6 P52701 S884R 884 S R 0.814 Pathogenic MSH6 P52701 S884T 884 S T 0.074 Neutral MSH6 P52701 S884V 884 S V 0.826 Pathogenic MSH6 P52701 S884W 884 S W 0.952 Pathogenic MSH6 P52701 S884Y 884 S Y 0.91 Pathogenic MSH6 P52701 K885A 885 K A 0.034 Neutral MSH6 P52701 K885C 885 K C 0.062 Neutral MSH6 P52701 K885D 885 K D 0.056 Neutral MSH6 P52701 K885E 885 K E 0.006 Neutral MSH6 P52701 K885F 885 K F 0.39 Neutral MSH6 P52701 K885G 885 K G 0.052 Neutral MSH6 P52701 K885H 885 K H 0.086 Neutral MSH6 P52701 K885I 885 K I 0.4 Neutral MSH6 P52701 K885L 885 K L 0.052 Neutral MSH6 P52701 K885M 885 K M 0.194 Neutral MSH6 P52701 K885N 885 K N 0.01 Neutral MSH6 P52701 K885P 885 K P 0.026 Neutral MSH6 P52701 K885Q 885 K Q 0.012 Neutral MSH6 P52701 K885R 885 K R 0.008 Neutral MSH6 P52701 K885S 885 K S 0.018 Neutral MSH6 P52701 K885T 885 K T 0.02 Neutral MSH6 P52701 K885V 885 K V 0.306 Neutral MSH6 P52701 K885W 885 K W 0.682 Pathogenic MSH6 P52701 K885Y 885 K Y 0.586 Pathogenic MSH6 P52701 I886A 886 I A 0.074 Neutral MSH6 P52701 I886C 886 I C 0.402 Neutral MSH6 P52701 I886D 886 I D 0.608 Pathogenic MSH6 P52701 I886E 886 I E 0.59 Pathogenic MSH6 P52701 I886F 886 I F 0.216 Neutral MSH6 P52701 I886G 886 I G 0.586 Pathogenic MSH6 P52701 I886H 886 I H 0.464 Neutral MSH6 P52701 I886K 886 I K 0.108 Neutral MSH6 P52701 I886L 886 I L 0.14 Neutral MSH6 P52701 I886M 886 I M 0.054 Neutral MSH6 P52701 I886N 886 I N 0.652 Pathogenic MSH6 P52701 I886P 886 I P 0.6 Pathogenic MSH6 P52701 I886Q 886 I Q 0.15 Neutral MSH6 P52701 I886R 886 I R 0.556 Pathogenic MSH6 P52701 I886S 886 I S 0.498 Neutral MSH6 P52701 I886T 886 I T 0.032 Neutral MSH6 P52701 I886V 886 I V 0.006 Neutral MSH6 P52701 I886W 886 I W 0.902 Pathogenic MSH6 P52701 I886Y 886 I Y 0.906 Pathogenic MSH6 P52701 L887A 887 L A 0.188 Neutral MSH6 P52701 L887C 887 L C 0.698 Pathogenic MSH6 P52701 L887D 887 L D 0.91 Pathogenic MSH6 P52701 L887E 887 L E 0.5 Pathogenic MSH6 P52701 L887F 887 L F 0.96 Pathogenic MSH6 P52701 L887G 887 L G 0.806 Pathogenic MSH6 P52701 L887H 887 L H 0.806 Pathogenic MSH6 P52701 L887I 887 L I 0.14 Neutral MSH6 P52701 L887K 887 L K 0.746 Pathogenic MSH6 P52701 L887M 887 L M 0.18 Neutral MSH6 P52701 L887N 887 L N 0.78 Pathogenic MSH6 P52701 L887P 887 L P 0.994 Pathogenic MSH6 P52701 L887Q 887 L Q 0.624 Pathogenic MSH6 P52701 L887R 887 L R 0.996 Pathogenic MSH6 P52701 L887S 887 L S 0.338 Neutral MSH6 P52701 L887T 887 L T 0.594 Pathogenic MSH6 P52701 L887V 887 L V 0.072 Neutral MSH6 P52701 L887W 887 L W 0.816 Pathogenic MSH6 P52701 L887Y 887 L Y 0.888 Pathogenic MSH6 P52701 K888A 888 K A 0.038 Neutral MSH6 P52701 K888C 888 K C 0.09 Neutral MSH6 P52701 K888D 888 K D 0.004 Neutral MSH6 P52701 K888E 888 K E 0.006 Neutral MSH6 P52701 K888F 888 K F 0.384 Neutral MSH6 P52701 K888G 888 K G 0.046 Neutral MSH6 P52701 K888H 888 K H 0.002 Neutral MSH6 P52701 K888I 888 K I 0.246 Neutral MSH6 P52701 K888L 888 K L 0.056 Neutral MSH6 P52701 K888M 888 K M 0.304 Neutral MSH6 P52701 K888N 888 K N 0.012 Neutral MSH6 P52701 K888P 888 K P 0.43 Neutral MSH6 P52701 K888Q 888 K Q 0.014 Neutral MSH6 P52701 K888R 888 K R 0.008 Neutral MSH6 P52701 K888S 888 K S 0.018 Neutral MSH6 P52701 K888T 888 K T 0.022 Neutral MSH6 P52701 K888V 888 K V 0.06 Neutral MSH6 P52701 K888W 888 K W 0.736 Pathogenic MSH6 P52701 K888Y 888 K Y 0.632 Pathogenic MSH6 P52701 Q889A 889 Q A 0.186 Neutral MSH6 P52701 Q889C 889 Q C 0.36 Neutral MSH6 P52701 Q889D 889 Q D 0.076 Neutral MSH6 P52701 Q889E 889 Q E 0.072 Neutral MSH6 P52701 Q889F 889 Q F 0.578 Pathogenic MSH6 P52701 Q889G 889 Q G 0.38 Neutral MSH6 P52701 Q889H 889 Q H 0.096 Neutral MSH6 P52701 Q889I 889 Q I 0.876 Pathogenic MSH6 P52701 Q889K 889 Q K 0.076 Neutral MSH6 P52701 Q889L 889 Q L 0.246 Neutral MSH6 P52701 Q889M 889 Q M 0.714 Pathogenic MSH6 P52701 Q889N 889 Q N 0.212 Neutral MSH6 P52701 Q889P 889 Q P 0.844 Pathogenic MSH6 P52701 Q889R 889 Q R 0.11 Neutral MSH6 P52701 Q889S 889 Q S 0.12 Neutral MSH6 P52701 Q889T 889 Q T 0.308 Neutral MSH6 P52701 Q889V 889 Q V 0.82 Pathogenic MSH6 P52701 Q889W 889 Q W 0.93 Pathogenic MSH6 P52701 Q889Y 889 Q Y 0.93 Pathogenic MSH6 P52701 D89A 89 D A 0.082 Neutral MSH6 P52701 D89C 89 D C 0.148 Neutral MSH6 P52701 D89E 89 D E 0.014 Neutral MSH6 P52701 D89F 89 D F 0.37 Neutral MSH6 P52701 D89G 89 D G 0.17 Neutral MSH6 P52701 D89H 89 D H 0.09 Neutral MSH6 P52701 D89I 89 D I 0.262 Neutral MSH6 P52701 D89K 89 D K 0.176 Neutral MSH6 P52701 D89L 89 D L 0.108 Neutral MSH6 P52701 D89M 89 D M 0.19 Neutral MSH6 P52701 D89N 89 D N 0.058 Neutral MSH6 P52701 D89P 89 D P 0.144 Neutral MSH6 P52701 D89Q 89 D Q 0.172 Neutral MSH6 P52701 D89R 89 D R 0.166 Neutral MSH6 P52701 D89S 89 D S 0.196 Neutral MSH6 P52701 D89T 89 D T 0.1 Neutral MSH6 P52701 D89V 89 D V 0.242 Neutral MSH6 P52701 D89W 89 D W 0.434 Neutral MSH6 P52701 D89Y 89 D Y 0.404 Neutral MSH6 P52701 V890A 890 V A 0.092 Neutral MSH6 P52701 V890C 890 V C 0.034 Neutral MSH6 P52701 V890D 890 V D 0.436 Neutral MSH6 P52701 V890E 890 V E 0.514 Pathogenic MSH6 P52701 V890F 890 V F 0.62 Pathogenic MSH6 P52701 V890G 890 V G 0.64 Pathogenic MSH6 P52701 V890H 890 V H 0.232 Neutral MSH6 P52701 V890I 890 V I 0.05 Neutral MSH6 P52701 V890K 890 V K 0.804 Pathogenic MSH6 P52701 V890L 890 V L 0.102 Neutral MSH6 P52701 V890M 890 V M 0.51 Pathogenic MSH6 P52701 V890N 890 V N 0.662 Pathogenic MSH6 P52701 V890P 890 V P 0.868 Pathogenic MSH6 P52701 V890Q 890 V Q 0.526 Pathogenic MSH6 P52701 V890R 890 V R 0.842 Pathogenic MSH6 P52701 V890S 890 V S 0.052 Neutral MSH6 P52701 V890T 890 V T 0.028 Neutral MSH6 P52701 V890W 890 V W 0.584 Pathogenic MSH6 P52701 V890Y 890 V Y 0.556 Pathogenic MSH6 P52701 I891A 891 I A 0.168 Neutral MSH6 P52701 I891C 891 I C 0.202 Neutral MSH6 P52701 I891D 891 I D 0.566 Pathogenic MSH6 P52701 I891E 891 I E 0.516 Pathogenic MSH6 P52701 I891F 891 I F 0.164 Neutral MSH6 P52701 I891G 891 I G 0.54 Pathogenic MSH6 P52701 I891H 891 I H 0.434 Neutral MSH6 P52701 I891K 891 I K 0.57 Pathogenic MSH6 P52701 I891L 891 I L 0.014 Neutral MSH6 P52701 I891M 891 I M 0.194 Neutral MSH6 P52701 I891N 891 I N 0.644 Pathogenic MSH6 P52701 I891P 891 I P 0.598 Pathogenic MSH6 P52701 I891Q 891 I Q 0.19 Neutral MSH6 P52701 I891R 891 I R 0.632 Pathogenic MSH6 P52701 I891S 891 I S 0.104 Neutral MSH6 P52701 I891T 891 I T 0.028 Neutral MSH6 P52701 I891V 891 I V 0.012 Neutral MSH6 P52701 I891W 891 I W 0.898 Pathogenic MSH6 P52701 I891Y 891 I Y 0.904 Pathogenic MSH6 P52701 S892A 892 S A 0.032 Neutral MSH6 P52701 S892C 892 S C 0.226 Neutral MSH6 P52701 S892D 892 S D 0.04 Neutral MSH6 P52701 S892E 892 S E 0.37 Neutral MSH6 P52701 S892F 892 S F 0.756 Pathogenic MSH6 P52701 S892G 892 S G 0.032 Neutral MSH6 P52701 S892H 892 S H 0.508 Pathogenic MSH6 P52701 S892I 892 S I 0.412 Neutral MSH6 P52701 S892K 892 S K 0.376 Neutral MSH6 P52701 S892L 892 S L 0.114 Neutral MSH6 P52701 S892M 892 S M 0.68 Pathogenic MSH6 P52701 S892N 892 S N 0.048 Neutral MSH6 P52701 S892P 892 S P 0.462 Neutral MSH6 P52701 S892Q 892 S Q 0.402 Neutral MSH6 P52701 S892R 892 S R 0.408 Neutral MSH6 P52701 S892T 892 S T 0.05 Neutral MSH6 P52701 S892V 892 S V 0.71 Pathogenic MSH6 P52701 S892W 892 S W 0.904 Pathogenic MSH6 P52701 S892Y 892 S Y 0.878 Pathogenic MSH6 P52701 L893A 893 L A 0.008 Neutral MSH6 P52701 L893C 893 L C 0.056 Neutral MSH6 P52701 L893D 893 L D 0.098 Neutral MSH6 P52701 L893E 893 L E 0.044 Neutral MSH6 P52701 L893F 893 L F 0.128 Neutral MSH6 P52701 L893G 893 L G 0.192 Neutral MSH6 P52701 L893H 893 L H 0.084 Neutral MSH6 P52701 L893I 893 L I 0.002 Neutral MSH6 P52701 L893K 893 L K 0.186 Neutral MSH6 P52701 L893M 893 L M 0.032 Neutral MSH6 P52701 L893N 893 L N 0.146 Neutral MSH6 P52701 L893P 893 L P 0.25 Neutral MSH6 P52701 L893Q 893 L Q 0.064 Neutral MSH6 P52701 L893R 893 L R 0.288 Neutral MSH6 P52701 L893S 893 L S 0.01 Neutral MSH6 P52701 L893T 893 L T 0.012 Neutral MSH6 P52701 L893V 893 L V 0 Neutral MSH6 P52701 L893W 893 L W 0.384 Neutral MSH6 P52701 L893Y 893 L Y 0.328 Neutral MSH6 P52701 Q894A 894 Q A 0.138 Neutral MSH6 P52701 Q894C 894 Q C 0.082 Neutral MSH6 P52701 Q894D 894 Q D 0 Neutral MSH6 P52701 Q894E 894 Q E 0.008 Neutral MSH6 P52701 Q894F 894 Q F 0.26 Neutral MSH6 P52701 Q894G 894 Q G 0.036 Neutral MSH6 P52701 Q894H 894 Q H 0.262 Neutral MSH6 P52701 Q894I 894 Q I 0.274 Neutral MSH6 P52701 Q894K 894 Q K 0.018 Neutral MSH6 P52701 Q894L 894 Q L 0.242 Neutral MSH6 P52701 Q894M 894 Q M 0.054 Neutral MSH6 P52701 Q894N 894 Q N 0.082 Neutral MSH6 P52701 Q894P 894 Q P 0.22 Neutral MSH6 P52701 Q894R 894 Q R 0.008 Neutral MSH6 P52701 Q894S 894 Q S 0.036 Neutral MSH6 P52701 Q894T 894 Q T 0.014 Neutral MSH6 P52701 Q894V 894 Q V 0.268 Neutral MSH6 P52701 Q894W 894 Q W 0.42 Neutral MSH6 P52701 Q894Y 894 Q Y 0.336 Neutral MSH6 P52701 T895A 895 T A 0 Neutral MSH6 P52701 T895C 895 T C 0.034 Neutral MSH6 P52701 T895D 895 T D 0.024 Neutral MSH6 P52701 T895E 895 T E 0.05 Neutral MSH6 P52701 T895F 895 T F 0.214 Neutral MSH6 P52701 T895G 895 T G 0.002 Neutral MSH6 P52701 T895H 895 T H 0.084 Neutral MSH6 P52701 T895I 895 T I 0.096 Neutral MSH6 P52701 T895K 895 T K 0.002 Neutral MSH6 P52701 T895L 895 T L 0.074 Neutral MSH6 P52701 T895M 895 T M 0.098 Neutral MSH6 P52701 T895N 895 T N 0.02 Neutral MSH6 P52701 T895P 895 T P 0.1 Neutral MSH6 P52701 T895Q 895 T Q 0.01 Neutral MSH6 P52701 T895R 895 T R 0.26 Neutral MSH6 P52701 T895S 895 T S 0 Neutral MSH6 P52701 T895V 895 T V 0.206 Neutral MSH6 P52701 T895W 895 T W 0.466 Neutral MSH6 P52701 T895Y 895 T Y 0.424 Neutral MSH6 P52701 K896A 896 K A 0.096 Neutral MSH6 P52701 K896C 896 K C 0.028 Neutral MSH6 P52701 K896D 896 K D 0.002 Neutral MSH6 P52701 K896E 896 K E 0.004 Neutral MSH6 P52701 K896F 896 K F 0.212 Neutral MSH6 P52701 K896G 896 K G 0.042 Neutral MSH6 P52701 K896H 896 K H 0.048 Neutral MSH6 P52701 K896I 896 K I 0.042 Neutral MSH6 P52701 K896L 896 K L 0.148 Neutral MSH6 P52701 K896M 896 K M 0.106 Neutral MSH6 P52701 K896N 896 K N 0.05 Neutral MSH6 P52701 K896P 896 K P 0.236 Neutral MSH6 P52701 K896Q 896 K Q 0.006 Neutral MSH6 P52701 K896R 896 K R 0.004 Neutral MSH6 P52701 K896S 896 K S 0.024 Neutral MSH6 P52701 K896T 896 K T 0.012 Neutral MSH6 P52701 K896V 896 K V 0.12 Neutral MSH6 P52701 K896W 896 K W 0.396 Neutral MSH6 P52701 K896Y 896 K Y 0.326 Neutral MSH6 P52701 N897A 897 N A 0.052 Neutral MSH6 P52701 N897C 897 N C 0.158 Neutral MSH6 P52701 N897D 897 N D 0.008 Neutral MSH6 P52701 N897E 897 N E 0.02 Neutral MSH6 P52701 N897F 897 N F 0.224 Neutral MSH6 P52701 N897G 897 N G 0.02 Neutral MSH6 P52701 N897H 897 N H 0.262 Neutral MSH6 P52701 N897I 897 N I 0.266 Neutral MSH6 P52701 N897K 897 N K 0.038 Neutral MSH6 P52701 N897L 897 N L 0.272 Neutral MSH6 P52701 N897M 897 N M 0.22 Neutral MSH6 P52701 N897P 897 N P 0.338 Neutral MSH6 P52701 N897Q 897 N Q 0.014 Neutral MSH6 P52701 N897R 897 N R 0.136 Neutral MSH6 P52701 N897S 897 N S 0.002 Neutral MSH6 P52701 N897T 897 N T 0.024 Neutral MSH6 P52701 N897V 897 N V 0.12 Neutral MSH6 P52701 N897W 897 N W 0.446 Neutral MSH6 P52701 N897Y 897 N Y 0.402 Neutral MSH6 P52701 P898A 898 P A 0.176 Neutral MSH6 P52701 P898C 898 P C 0.148 Neutral MSH6 P52701 P898D 898 P D 0.028 Neutral MSH6 P52701 P898E 898 P E 0.056 Neutral MSH6 P52701 P898F 898 P F 0.226 Neutral MSH6 P52701 P898G 898 P G 0.01 Neutral MSH6 P52701 P898H 898 P H 0.266 Neutral MSH6 P52701 P898I 898 P I 0.104 Neutral MSH6 P52701 P898K 898 P K 0.1 Neutral MSH6 P52701 P898L 898 P L 0.094 Neutral MSH6 P52701 P898M 898 P M 0.22 Neutral MSH6 P52701 P898N 898 P N 0.004 Neutral MSH6 P52701 P898Q 898 P Q 0.06 Neutral MSH6 P52701 P898R 898 P R 0.202 Neutral MSH6 P52701 P898S 898 P S 0.002 Neutral MSH6 P52701 P898T 898 P T 0.188 Neutral MSH6 P52701 P898V 898 P V 0.13 Neutral MSH6 P52701 P898W 898 P W 0.39 Neutral MSH6 P52701 P898Y 898 P Y 0.32 Neutral MSH6 P52701 E899A 899 E A 0.118 Neutral MSH6 P52701 E899C 899 E C 0.064 Neutral MSH6 P52701 E899D 899 E D 0 Neutral MSH6 P52701 E899F 899 E F 0.272 Neutral MSH6 P52701 E899G 899 E G 0 Neutral MSH6 P52701 E899H 899 E H 0.04 Neutral MSH6 P52701 E899I 899 E I 0.284 Neutral MSH6 P52701 E899K 899 E K 0.002 Neutral MSH6 P52701 E899L 899 E L 0.07 Neutral MSH6 P52701 E899M 899 E M 0.164 Neutral MSH6 P52701 E899N 899 E N 0.002 Neutral MSH6 P52701 E899P 899 E P 0.282 Neutral MSH6 P52701 E899Q 899 E Q 0 Neutral MSH6 P52701 E899R 899 E R 0.016 Neutral MSH6 P52701 E899S 899 E S 0.058 Neutral MSH6 P52701 E899T 899 E T 0.14 Neutral MSH6 P52701 E899V 899 E V 0.142 Neutral MSH6 P52701 E899W 899 E W 0.43 Neutral MSH6 P52701 E899Y 899 E Y 0.296 Neutral MSH6 P52701 S9A 9 S A 0.086 Neutral MSH6 P52701 S9C 9 S C 0.032 Neutral MSH6 P52701 S9D 9 S D 0.044 Neutral MSH6 P52701 S9E 9 S E 0.148 Neutral MSH6 P52701 S9F 9 S F 0.276 Neutral MSH6 P52701 S9G 9 S G 0.064 Neutral MSH6 P52701 S9H 9 S H 0.238 Neutral MSH6 P52701 S9I 9 S I 0.026 Neutral MSH6 P52701 S9K 9 S K 0.148 Neutral MSH6 P52701 S9L 9 S L 0.028 Neutral MSH6 P52701 S9M 9 S M 0.332 Neutral MSH6 P52701 S9N 9 S N 0 Neutral MSH6 P52701 S9P 9 S P 0.116 Neutral MSH6 P52701 S9Q 9 S Q 0.158 Neutral MSH6 P52701 S9R 9 S R 0.248 Neutral MSH6 P52701 S9T 9 S T 0.11 Neutral MSH6 P52701 S9V 9 S V 0.248 Neutral MSH6 P52701 S9W 9 S W 0.49 Neutral MSH6 P52701 S9Y 9 S Y 0.448 Neutral MSH6 P52701 F90A 90 F A 0.12 Neutral MSH6 P52701 F90C 90 F C 0.086 Neutral MSH6 P52701 F90D 90 F D 0.232 Neutral MSH6 P52701 F90E 90 F E 0.272 Neutral MSH6 P52701 F90G 90 F G 0.186 Neutral MSH6 P52701 F90H 90 F H 0.104 Neutral MSH6 P52701 F90I 90 F I 0.122 Neutral MSH6 P52701 F90K 90 F K 0.258 Neutral MSH6 P52701 F90L 90 F L 0.102 Neutral MSH6 P52701 F90M 90 F M 0.118 Neutral MSH6 P52701 F90N 90 F N 0.246 Neutral MSH6 P52701 F90P 90 F P 0.27 Neutral MSH6 P52701 F90Q 90 F Q 0.248 Neutral MSH6 P52701 F90R 90 F R 0.222 Neutral MSH6 P52701 F90S 90 F S 0.258 Neutral MSH6 P52701 F90T 90 F T 0.226 Neutral MSH6 P52701 F90V 90 F V 0.226 Neutral MSH6 P52701 F90W 90 F W 0.46 Neutral MSH6 P52701 F90Y 90 F Y 0.024 Neutral MSH6 P52701 G900A 900 G A 0.118 Neutral MSH6 P52701 G900C 900 G C 0.502 Pathogenic MSH6 P52701 G900D 900 G D 0.766 Pathogenic MSH6 P52701 G900E 900 G E 0.814 Pathogenic MSH6 P52701 G900F 900 G F 0.946 Pathogenic MSH6 P52701 G900H 900 G H 0.95 Pathogenic MSH6 P52701 G900I 900 G I 0.93 Pathogenic MSH6 P52701 G900K 900 G K 0.954 Pathogenic MSH6 P52701 G900L 900 G L 0.772 Pathogenic MSH6 P52701 G900M 900 G M 0.95 Pathogenic MSH6 P52701 G900N 900 G N 0.732 Pathogenic MSH6 P52701 G900P 900 G P 0.898 Pathogenic MSH6 P52701 G900Q 900 G Q 0.798 Pathogenic MSH6 P52701 G900R 900 G R 0.968 Pathogenic MSH6 P52701 G900S 900 G S 0.366 Neutral MSH6 P52701 G900T 900 G T 0.82 Pathogenic MSH6 P52701 G900V 900 G V 0.936 Pathogenic MSH6 P52701 G900W 900 G W 0.946 Pathogenic MSH6 P52701 G900Y 900 G Y 0.936 Pathogenic MSH6 P52701 R901A 901 R A 0.036 Neutral MSH6 P52701 R901C 901 R C 0.008 Neutral MSH6 P52701 R901D 901 R D 0.02 Neutral MSH6 P52701 R901E 901 R E 0.024 Neutral MSH6 P52701 R901F 901 R F 0.046 Neutral MSH6 P52701 R901G 901 R G 0.002 Neutral MSH6 P52701 R901H 901 R H 0.004 Neutral MSH6 P52701 R901I 901 R I 0.326 Neutral MSH6 P52701 R901K 901 R K 0.004 Neutral MSH6 P52701 R901L 901 R L 0.018 Neutral MSH6 P52701 R901M 901 R M 0.164 Neutral MSH6 P52701 R901N 901 R N 0.01 Neutral MSH6 P52701 R901P 901 R P 0.254 Neutral MSH6 P52701 R901Q 901 R Q 0.01 Neutral MSH6 P52701 R901S 901 R S 0.016 Neutral MSH6 P52701 R901T 901 R T 0.144 Neutral MSH6 P52701 R901V 901 R V 0.062 Neutral MSH6 P52701 R901W 901 R W 0.426 Neutral MSH6 P52701 R901Y 901 R Y 0.368 Neutral MSH6 P52701 F902A 902 F A 0.158 Neutral MSH6 P52701 F902C 902 F C 0.308 Neutral MSH6 P52701 F902D 902 F D 0.578 Pathogenic MSH6 P52701 F902E 902 F E 0.674 Pathogenic MSH6 P52701 F902G 902 F G 0.366 Neutral MSH6 P52701 F902H 902 F H 0.352 Neutral MSH6 P52701 F902I 902 F I 0.07 Neutral MSH6 P52701 F902K 902 F K 0.63 Pathogenic MSH6 P52701 F902L 902 F L 0.024 Neutral MSH6 P52701 F902M 902 F M 0.032 Neutral MSH6 P52701 F902N 902 F N 0.476 Neutral MSH6 P52701 F902P 902 F P 0.116 Neutral MSH6 P52701 F902Q 902 F Q 0.602 Pathogenic MSH6 P52701 F902R 902 F R 0.502 Pathogenic MSH6 P52701 F902S 902 F S 0.454 Neutral MSH6 P52701 F902T 902 F T 0.412 Neutral MSH6 P52701 F902V 902 F V 0.028 Neutral MSH6 P52701 F902W 902 F W 0.854 Pathogenic MSH6 P52701 F902Y 902 F Y 0.046 Neutral MSH6 P52701 P903A 903 P A 0.262 Neutral MSH6 P52701 P903C 903 P C 0.904 Pathogenic MSH6 P52701 P903D 903 P D 0.854 Pathogenic MSH6 P52701 P903E 903 P E 0.274 Neutral MSH6 P52701 P903F 903 P F 0.998 Pathogenic MSH6 P52701 P903G 903 P G 0.66 Pathogenic MSH6 P52701 P903H 903 P H 0.972 Pathogenic MSH6 P52701 P903I 903 P I 0.932 Pathogenic MSH6 P52701 P903K 903 P K 0.568 Pathogenic MSH6 P52701 P903L 903 P L 0.358 Neutral MSH6 P52701 P903M 903 P M 0.95 Pathogenic MSH6 P52701 P903N 903 P N 0.418 Neutral MSH6 P52701 P903Q 903 P Q 0.542 Pathogenic MSH6 P52701 P903R 903 P R 0.976 Pathogenic MSH6 P52701 P903S 903 P S 0.192 Neutral MSH6 P52701 P903T 903 P T 0.362 Neutral MSH6 P52701 P903V 903 P V 0.206 Neutral MSH6 P52701 P903W 903 P W 0.93 Pathogenic MSH6 P52701 P903Y 903 P Y 0.924 Pathogenic MSH6 P52701 D904A 904 D A 0.332 Neutral MSH6 P52701 D904C 904 D C 0.91 Pathogenic MSH6 P52701 D904E 904 D E 0.264 Neutral MSH6 P52701 D904F 904 D F 0.984 Pathogenic MSH6 P52701 D904G 904 D G 0.376 Neutral MSH6 P52701 D904H 904 D H 0.314 Neutral MSH6 P52701 D904I 904 D I 0.974 Pathogenic MSH6 P52701 D904K 904 D K 0.812 Pathogenic MSH6 P52701 D904L 904 D L 0.982 Pathogenic MSH6 P52701 D904M 904 D M 0.944 Pathogenic MSH6 P52701 D904N 904 D N 0.066 Neutral MSH6 P52701 D904P 904 D P 0.912 Pathogenic MSH6 P52701 D904Q 904 D Q 0.186 Neutral MSH6 P52701 D904R 904 D R 0.526 Pathogenic MSH6 P52701 D904S 904 D S 0.116 Neutral MSH6 P52701 D904T 904 D T 0.458 Neutral MSH6 P52701 D904V 904 D V 0.996 Pathogenic MSH6 P52701 D904W 904 D W 0.986 Pathogenic MSH6 P52701 D904Y 904 D Y 0.924 Pathogenic MSH6 P52701 L905A 905 L A 0.562 Pathogenic MSH6 P52701 L905C 905 L C 0.682 Pathogenic MSH6 P52701 L905D 905 L D 0.902 Pathogenic MSH6 P52701 L905E 905 L E 0.882 Pathogenic MSH6 P52701 L905F 905 L F 0.778 Pathogenic MSH6 P52701 L905G 905 L G 0.804 Pathogenic MSH6 P52701 L905H 905 L H 0.802 Pathogenic MSH6 P52701 L905I 905 L I 0.134 Neutral MSH6 P52701 L905K 905 L K 0.746 Pathogenic MSH6 P52701 L905M 905 L M 0.162 Neutral MSH6 P52701 L905N 905 L N 0.772 Pathogenic MSH6 P52701 L905P 905 L P 0.998 Pathogenic MSH6 P52701 L905Q 905 L Q 0.618 Pathogenic MSH6 P52701 L905R 905 L R 0.996 Pathogenic MSH6 P52701 L905S 905 L S 0.608 Pathogenic MSH6 P52701 L905T 905 L T 0.33 Neutral MSH6 P52701 L905V 905 L V 0.07 Neutral MSH6 P52701 L905W 905 L W 0.934 Pathogenic MSH6 P52701 L905Y 905 L Y 0.656 Pathogenic MSH6 P52701 T906A 906 T A 0.028 Neutral MSH6 P52701 T906C 906 T C 0.042 Neutral MSH6 P52701 T906D 906 T D 0.064 Neutral MSH6 P52701 T906E 906 T E 0.092 Neutral MSH6 P52701 T906F 906 T F 0.588 Pathogenic MSH6 P52701 T906G 906 T G 0.042 Neutral MSH6 P52701 T906H 906 T H 0.134 Neutral MSH6 P52701 T906I 906 T I 0.356 Neutral MSH6 P52701 T906K 906 T K 0.046 Neutral MSH6 P52701 T906L 906 T L 0.106 Neutral MSH6 P52701 T906M 906 T M 0.486 Neutral MSH6 P52701 T906N 906 T N 0.026 Neutral MSH6 P52701 T906P 906 T P 0.446 Neutral MSH6 P52701 T906Q 906 T Q 0.03 Neutral MSH6 P52701 T906R 906 T R 0.368 Neutral MSH6 P52701 T906S 906 T S 0.026 Neutral MSH6 P52701 T906V 906 T V 0.152 Neutral MSH6 P52701 T906W 906 T W 0.87 Pathogenic MSH6 P52701 T906Y 906 T Y 0.862 Pathogenic MSH6 P52701 V907A 907 V A 0.036 Neutral MSH6 P52701 V907C 907 V C 0.318 Neutral MSH6 P52701 V907D 907 V D 0.082 Neutral MSH6 P52701 V907E 907 V E 0.12 Neutral MSH6 P52701 V907F 907 V F 0.558 Pathogenic MSH6 P52701 V907G 907 V G 0.106 Neutral MSH6 P52701 V907H 907 V H 0.428 Neutral MSH6 P52701 V907I 907 V I 0.04 Neutral MSH6 P52701 V907K 907 V K 0.144 Neutral MSH6 P52701 V907L 907 V L 0.376 Neutral MSH6 P52701 V907M 907 V M 0.056 Neutral MSH6 P52701 V907N 907 V N 0.16 Neutral MSH6 P52701 V907P 907 V P 0.086 Neutral MSH6 P52701 V907Q 907 V Q 0.326 Neutral MSH6 P52701 V907R 907 V R 0.592 Pathogenic MSH6 P52701 V907S 907 V S 0.054 Neutral MSH6 P52701 V907T 907 V T 0.038 Neutral MSH6 P52701 V907W 907 V W 0.722 Pathogenic MSH6 P52701 V907Y 907 V Y 0.698 Pathogenic MSH6 P52701 E908A 908 E A 0.082 Neutral MSH6 P52701 E908C 908 E C 0.108 Neutral MSH6 P52701 E908D 908 E D 0.002 Neutral MSH6 P52701 E908F 908 E F 0.23 Neutral MSH6 P52701 E908G 908 E G 0.07 Neutral MSH6 P52701 E908H 908 E H 0.016 Neutral MSH6 P52701 E908I 908 E I 0.14 Neutral MSH6 P52701 E908K 908 E K 0.002 Neutral MSH6 P52701 E908L 908 E L 0.06 Neutral MSH6 P52701 E908M 908 E M 0.12 Neutral MSH6 P52701 E908N 908 E N 0.002 Neutral MSH6 P52701 E908P 908 E P 0.068 Neutral MSH6 P52701 E908Q 908 E Q 0 Neutral MSH6 P52701 E908R 908 E R 0.02 Neutral MSH6 P52701 E908S 908 E S 0.02 Neutral MSH6 P52701 E908T 908 E T 0.01 Neutral MSH6 P52701 E908V 908 E V 0.044 Neutral MSH6 P52701 E908W 908 E W 0.694 Pathogenic MSH6 P52701 E908Y 908 E Y 0.27 Neutral MSH6 P52701 L909A 909 L A 0.702 Pathogenic MSH6 P52701 L909C 909 L C 0.806 Pathogenic MSH6 P52701 L909D 909 L D 0.884 Pathogenic MSH6 P52701 L909E 909 L E 0.866 Pathogenic MSH6 P52701 L909F 909 L F 0.828 Pathogenic MSH6 P52701 L909G 909 L G 0.858 Pathogenic MSH6 P52701 L909H 909 L H 0.898 Pathogenic MSH6 P52701 L909I 909 L I 0.226 Neutral MSH6 P52701 L909K 909 L K 0.69 Pathogenic MSH6 P52701 L909M 909 L M 0.562 Pathogenic MSH6 P52701 L909N 909 L N 0.796 Pathogenic MSH6 P52701 L909P 909 L P 0.966 Pathogenic MSH6 P52701 L909Q 909 L Q 0.756 Pathogenic MSH6 P52701 L909R 909 L R 0.974 Pathogenic MSH6 P52701 L909S 909 L S 0.68 Pathogenic MSH6 P52701 L909T 909 L T 0.598 Pathogenic MSH6 P52701 L909V 909 L V 0.072 Neutral MSH6 P52701 L909W 909 L W 0.846 Pathogenic MSH6 P52701 L909Y 909 L Y 0.868 Pathogenic MSH6 P52701 S91A 91 S A 0.068 Neutral MSH6 P52701 S91C 91 S C 0.032 Neutral MSH6 P52701 S91D 91 S D 0.044 Neutral MSH6 P52701 S91E 91 S E 0.124 Neutral MSH6 P52701 S91F 91 S F 0.276 Neutral MSH6 P52701 S91G 91 S G 0.036 Neutral MSH6 P52701 S91H 91 S H 0.188 Neutral MSH6 P52701 S91I 91 S I 0.026 Neutral MSH6 P52701 S91K 91 S K 0.15 Neutral MSH6 P52701 S91L 91 S L 0.068 Neutral MSH6 P52701 S91M 91 S M 0.332 Neutral MSH6 P52701 S91N 91 S N 0 Neutral MSH6 P52701 S91P 91 S P 0.116 Neutral MSH6 P52701 S91Q 91 S Q 0.17 Neutral MSH6 P52701 S91R 91 S R 0.17 Neutral MSH6 P52701 S91T 91 S T 0.02 Neutral MSH6 P52701 S91V 91 S V 0.288 Neutral MSH6 P52701 S91W 91 S W 0.49 Neutral MSH6 P52701 S91Y 91 S Y 0.448 Neutral MSH6 P52701 N910A 910 N A 0.046 Neutral MSH6 P52701 N910C 910 N C 0.506 Pathogenic MSH6 P52701 N910D 910 N D 0.024 Neutral MSH6 P52701 N910E 910 N E 0.032 Neutral MSH6 P52701 N910F 910 N F 0.866 Pathogenic MSH6 P52701 N910G 910 N G 0.052 Neutral MSH6 P52701 N910H 910 N H 0.16 Neutral MSH6 P52701 N910I 910 N I 0.752 Pathogenic MSH6 P52701 N910K 910 N K 0.066 Neutral MSH6 P52701 N910L 910 N L 0.422 Neutral MSH6 P52701 N910M 910 N M 0.37 Neutral MSH6 P52701 N910P 910 N P 0.658 Pathogenic MSH6 P52701 N910Q 910 N Q 0.028 Neutral MSH6 P52701 N910R 910 N R 0.374 Neutral MSH6 P52701 N910S 910 N S 0.024 Neutral MSH6 P52701 N910T 910 N T 0.026 Neutral MSH6 P52701 N910V 910 N V 0.784 Pathogenic MSH6 P52701 N910W 910 N W 0.892 Pathogenic MSH6 P52701 N910Y 910 N Y 0.752 Pathogenic MSH6 P52701 R911A 911 R A 0.358 Neutral MSH6 P52701 R911C 911 R C 0.642 Pathogenic MSH6 P52701 R911D 911 R D 0.266 Neutral MSH6 P52701 R911E 911 R E 0.278 Neutral MSH6 P52701 R911F 911 R F 0.106 Neutral MSH6 P52701 R911G 911 R G 0.192 Neutral MSH6 P52701 R911H 911 R H 0.028 Neutral MSH6 P52701 R911I 911 R I 0.8 Pathogenic MSH6 P52701 R911K 911 R K 0.06 Neutral MSH6 P52701 R911L 911 R L 0.128 Neutral MSH6 P52701 R911M 911 R M 0.644 Pathogenic MSH6 P52701 R911N 911 R N 0.21 Neutral MSH6 P52701 R911P 911 R P 0.438 Neutral MSH6 P52701 R911Q 911 R Q 0.078 Neutral MSH6 P52701 R911S 911 R S 0.058 Neutral MSH6 P52701 R911T 911 R T 0.462 Neutral MSH6 P52701 R911V 911 R V 0.794 Pathogenic MSH6 P52701 R911W 911 R W 0.55 Pathogenic MSH6 P52701 R911Y 911 R Y 0.14 Neutral MSH6 P52701 W912A 912 W A 0.41 Neutral MSH6 P52701 W912C 912 W C 0.414 Neutral MSH6 P52701 W912D 912 W D 0.48 Neutral MSH6 P52701 W912E 912 W E 0.776 Pathogenic MSH6 P52701 W912F 912 W F 0.14 Neutral MSH6 P52701 W912G 912 W G 0.414 Neutral MSH6 P52701 W912H 912 W H 0.652 Pathogenic MSH6 P52701 W912I 912 W I 0.264 Neutral MSH6 P52701 W912K 912 W K 0.872 Pathogenic MSH6 P52701 W912L 912 W L 0.196 Neutral MSH6 P52701 W912M 912 W M 0.654 Pathogenic MSH6 P52701 W912N 912 W N 0.424 Neutral MSH6 P52701 W912P 912 W P 0.526 Pathogenic MSH6 P52701 W912Q 912 W Q 0.554 Pathogenic MSH6 P52701 W912R 912 W R 0.662 Pathogenic MSH6 P52701 W912S 912 W S 0.424 Neutral MSH6 P52701 W912T 912 W T 0.41 Neutral MSH6 P52701 W912V 912 W V 0.264 Neutral MSH6 P52701 W912Y 912 W Y 0.41 Neutral MSH6 P52701 D913A 913 D A 0.136 Neutral MSH6 P52701 D913C 913 D C 0.728 Pathogenic MSH6 P52701 D913E 913 D E 0.032 Neutral MSH6 P52701 D913F 913 D F 0.41 Neutral MSH6 P52701 D913G 913 D G 0.404 Neutral MSH6 P52701 D913H 913 D H 0.332 Neutral MSH6 P52701 D913I 913 D I 0.886 Pathogenic MSH6 P52701 D913K 913 D K 0.116 Neutral MSH6 P52701 D913L 913 D L 0.884 Pathogenic MSH6 P52701 D913M 913 D M 0.746 Pathogenic MSH6 P52701 D913N 913 D N 0.142 Neutral MSH6 P52701 D913P 913 D P 0.802 Pathogenic MSH6 P52701 D913Q 913 D Q 0.026 Neutral MSH6 P52701 D913R 913 D R 0.476 Neutral MSH6 P52701 D913S 913 D S 0.02 Neutral MSH6 P52701 D913T 913 D T 0.072 Neutral MSH6 P52701 D913V 913 D V 0.822 Pathogenic MSH6 P52701 D913W 913 D W 0.97 Pathogenic MSH6 P52701 D913Y 913 D Y 0.948 Pathogenic MSH6 P52701 T914A 914 T A 0.088 Neutral MSH6 P52701 T914C 914 T C 0.384 Neutral MSH6 P52701 T914D 914 T D 0.112 Neutral MSH6 P52701 T914E 914 T E 0.142 Neutral MSH6 P52701 T914F 914 T F 0.696 Pathogenic MSH6 P52701 T914G 914 T G 0.234 Neutral MSH6 P52701 T914H 914 T H 0.248 Neutral MSH6 P52701 T914I 914 T I 0.508 Pathogenic MSH6 P52701 T914K 914 T K 0.094 Neutral MSH6 P52701 T914L 914 T L 0.444 Neutral MSH6 P52701 T914M 914 T M 0.63 Pathogenic MSH6 P52701 T914N 914 T N 0.02 Neutral MSH6 P52701 T914P 914 T P 0.6 Pathogenic MSH6 P52701 T914Q 914 T Q 0.144 Neutral MSH6 P52701 T914R 914 T R 0.454 Neutral MSH6 P52701 T914S 914 T S 0.024 Neutral MSH6 P52701 T914V 914 T V 0.412 Neutral MSH6 P52701 T914W 914 T W 0.914 Pathogenic MSH6 P52701 T914Y 914 T Y 0.908 Pathogenic MSH6 P52701 A915C 915 A C 0.648 Pathogenic MSH6 P52701 A915D 915 A D 0.788 Pathogenic MSH6 P52701 A915E 915 A E 0.818 Pathogenic MSH6 P52701 A915F 915 A F 0.932 Pathogenic MSH6 P52701 A915G 915 A G 0.47 Neutral MSH6 P52701 A915H 915 A H 0.818 Pathogenic MSH6 P52701 A915I 915 A I 0.888 Pathogenic MSH6 P52701 A915K 915 A K 0.878 Pathogenic MSH6 P52701 A915L 915 A L 0.902 Pathogenic MSH6 P52701 A915M 915 A M 0.492 Neutral MSH6 P52701 A915N 915 A N 0.736 Pathogenic MSH6 P52701 A915P 915 A P 0.818 Pathogenic MSH6 P52701 A915Q 915 A Q 0.764 Pathogenic MSH6 P52701 A915R 915 A R 0.874 Pathogenic MSH6 P52701 A915S 915 A S 0.008 Neutral MSH6 P52701 A915T 915 A T 0.576 Pathogenic MSH6 P52701 A915V 915 A V 0.682 Pathogenic MSH6 P52701 A915W 915 A W 0.924 Pathogenic MSH6 P52701 A915Y 915 A Y 0.914 Pathogenic MSH6 P52701 F916A 916 F A 0.224 Neutral MSH6 P52701 F916C 916 F C 0.264 Neutral MSH6 P52701 F916D 916 F D 0.538 Pathogenic MSH6 P52701 F916E 916 F E 0.624 Pathogenic MSH6 P52701 F916G 916 F G 0.336 Neutral MSH6 P52701 F916H 916 F H 0.294 Neutral MSH6 P52701 F916I 916 F I 0.41 Neutral MSH6 P52701 F916K 916 F K 0.576 Pathogenic MSH6 P52701 F916L 916 F L 0.336 Neutral MSH6 P52701 F916M 916 F M 0.304 Neutral MSH6 P52701 F916N 916 F N 0.528 Pathogenic MSH6 P52701 F916P 916 F P 0.734 Pathogenic MSH6 P52701 F916Q 916 F Q 0.556 Pathogenic MSH6 P52701 F916R 916 F R 0.598 Pathogenic MSH6 P52701 F916S 916 F S 0.432 Neutral MSH6 P52701 F916T 916 F T 0.422 Neutral MSH6 P52701 F916V 916 F V 0.472 Neutral MSH6 P52701 F916W 916 F W 0.862 Pathogenic MSH6 P52701 F916Y 916 F Y 0.548 Pathogenic MSH6 P52701 D917A 917 D A 0.772 Pathogenic MSH6 P52701 D917C 917 D C 0.842 Pathogenic MSH6 P52701 D917E 917 D E 0.73 Pathogenic MSH6 P52701 D917F 917 D F 0.97 Pathogenic MSH6 P52701 D917G 917 D G 0.9 Pathogenic MSH6 P52701 D917H 917 D H 0.57 Pathogenic MSH6 P52701 D917I 917 D I 0.79 Pathogenic MSH6 P52701 D917K 917 D K 0.716 Pathogenic MSH6 P52701 D917L 917 D L 0.954 Pathogenic MSH6 P52701 D917M 917 D M 0.934 Pathogenic MSH6 P52701 D917N 917 D N 0.18 Neutral MSH6 P52701 D917P 917 D P 0.866 Pathogenic MSH6 P52701 D917Q 917 D Q 0.518 Pathogenic MSH6 P52701 D917R 917 D R 0.95 Pathogenic MSH6 P52701 D917S 917 D S 0.134 Neutral MSH6 P52701 D917T 917 D T 0.35 Neutral MSH6 P52701 D917V 917 D V 0.754 Pathogenic MSH6 P52701 D917W 917 D W 0.976 Pathogenic MSH6 P52701 D917Y 917 D Y 0.966 Pathogenic MSH6 P52701 H918A 918 H A 0.148 Neutral MSH6 P52701 H918C 918 H C 0.288 Neutral MSH6 P52701 H918D 918 H D 0.264 Neutral MSH6 P52701 H918E 918 H E 0.38 Neutral MSH6 P52701 H918F 918 H F 0.734 Pathogenic MSH6 P52701 H918G 918 H G 0.32 Neutral MSH6 P52701 H918I 918 H I 0.668 Pathogenic MSH6 P52701 H918K 918 H K 0.112 Neutral MSH6 P52701 H918L 918 H L 0.16 Neutral MSH6 P52701 H918M 918 H M 0.524 Pathogenic MSH6 P52701 H918N 918 H N 0.224 Neutral MSH6 P52701 H918P 918 H P 0.224 Neutral MSH6 P52701 H918Q 918 H Q 0.02 Neutral MSH6 P52701 H918R 918 H R 0.016 Neutral MSH6 P52701 H918S 918 H S 0.372 Neutral MSH6 P52701 H918T 918 H T 0.376 Neutral MSH6 P52701 H918V 918 H V 0.238 Neutral MSH6 P52701 H918W 918 H W 0.566 Pathogenic MSH6 P52701 H918Y 918 H Y 0.786 Pathogenic MSH6 P52701 E919A 919 E A 0.156 Neutral MSH6 P52701 E919C 919 E C 0.348 Neutral MSH6 P52701 E919D 919 E D 0.014 Neutral MSH6 P52701 E919F 919 E F 0.726 Pathogenic MSH6 P52701 E919G 919 E G 0.05 Neutral MSH6 P52701 E919H 919 E H 0.484 Neutral MSH6 P52701 E919I 919 E I 0.782 Pathogenic MSH6 P52701 E919K 919 E K 0.024 Neutral MSH6 P52701 E919L 919 E L 0.772 Pathogenic MSH6 P52701 E919M 919 E M 0.592 Pathogenic MSH6 P52701 E919N 919 E N 0.01 Neutral MSH6 P52701 E919P 919 E P 0.2 Neutral MSH6 P52701 E919Q 919 E Q 0.008 Neutral MSH6 P52701 E919R 919 E R 0.062 Neutral MSH6 P52701 E919S 919 E S 0.038 Neutral MSH6 P52701 E919T 919 E T 0.034 Neutral MSH6 P52701 E919V 919 E V 0.068 Neutral MSH6 P52701 E919W 919 E W 0.89 Pathogenic MSH6 P52701 E919Y 919 E Y 0.8 Pathogenic MSH6 P52701 P92A 92 P A 0.032 Neutral MSH6 P52701 P92C 92 P C 0.156 Neutral MSH6 P52701 P92D 92 P D 0.078 Neutral MSH6 P52701 P92E 92 P E 0.12 Neutral MSH6 P52701 P92F 92 P F 0.318 Neutral MSH6 P52701 P92G 92 P G 0.092 Neutral MSH6 P52701 P92H 92 P H 0.304 Neutral MSH6 P52701 P92I 92 P I 0.096 Neutral MSH6 P52701 P92K 92 P K 0.23 Neutral MSH6 P52701 P92L 92 P L 0.12 Neutral MSH6 P52701 P92M 92 P M 0.248 Neutral MSH6 P52701 P92N 92 P N 0.068 Neutral MSH6 P52701 P92Q 92 P Q 0.236 Neutral MSH6 P52701 P92R 92 P R 0.25 Neutral MSH6 P52701 P92S 92 P S 0.114 Neutral MSH6 P52701 P92T 92 P T 0.126 Neutral MSH6 P52701 P92V 92 P V 0.074 Neutral MSH6 P52701 P92W 92 P W 0.43 Neutral MSH6 P52701 P92Y 92 P Y 0.358 Neutral MSH6 P52701 K920A 920 K A 0.07 Neutral MSH6 P52701 K920C 920 K C 0.196 Neutral MSH6 P52701 K920D 920 K D 0.042 Neutral MSH6 P52701 K920E 920 K E 0.018 Neutral MSH6 P52701 K920F 920 K F 0.848 Pathogenic MSH6 P52701 K920G 920 K G 0.358 Neutral MSH6 P52701 K920H 920 K H 0.396 Neutral MSH6 P52701 K920I 920 K I 0.428 Neutral MSH6 P52701 K920L 920 K L 0.138 Neutral MSH6 P52701 K920M 920 K M 0.558 Pathogenic MSH6 P52701 K920N 920 K N 0.148 Neutral MSH6 P52701 K920P 920 K P 0.834 Pathogenic MSH6 P52701 K920Q 920 K Q 0.03 Neutral MSH6 P52701 K920R 920 K R 0.036 Neutral MSH6 P52701 K920S 920 K S 0.034 Neutral MSH6 P52701 K920T 920 K T 0.04 Neutral MSH6 P52701 K920V 920 K V 0.106 Neutral MSH6 P52701 K920W 920 K W 0.98 Pathogenic MSH6 P52701 K920Y 920 K Y 0.932 Pathogenic MSH6 P52701 A921C 921 A C 0.578 Pathogenic MSH6 P52701 A921D 921 A D 0.734 Pathogenic MSH6 P52701 A921E 921 A E 0.864 Pathogenic MSH6 P52701 A921F 921 A F 0.956 Pathogenic MSH6 P52701 A921G 921 A G 0.342 Neutral MSH6 P52701 A921H 921 A H 0.85 Pathogenic MSH6 P52701 A921I 921 A I 0.95 Pathogenic MSH6 P52701 A921K 921 A K 0.924 Pathogenic MSH6 P52701 A921L 921 A L 0.968 Pathogenic MSH6 P52701 A921M 921 A M 0.836 Pathogenic MSH6 P52701 A921N 921 A N 0.852 Pathogenic MSH6 P52701 A921P 921 A P 0.96 Pathogenic MSH6 P52701 A921Q 921 A Q 0.804 Pathogenic MSH6 P52701 A921R 921 A R 0.952 Pathogenic MSH6 P52701 A921S 921 A S 0.168 Neutral MSH6 P52701 A921T 921 A T 0.296 Neutral MSH6 P52701 A921V 921 A V 0.48 Neutral MSH6 P52701 A921W 921 A W 0.964 Pathogenic MSH6 P52701 A921Y 921 A Y 0.954 Pathogenic MSH6 P52701 R922A 922 R A 0.122 Neutral MSH6 P52701 R922C 922 R C 0.642 Pathogenic MSH6 P52701 R922D 922 R D 0.054 Neutral MSH6 P52701 R922E 922 R E 0.066 Neutral MSH6 P52701 R922F 922 R F 0.896 Pathogenic MSH6 P52701 R922G 922 R G 0.192 Neutral MSH6 P52701 R922H 922 R H 0.108 Neutral MSH6 P52701 R922I 922 R I 0.798 Pathogenic MSH6 P52701 R922K 922 R K 0.064 Neutral MSH6 P52701 R922L 922 R L 0.116 Neutral MSH6 P52701 R922M 922 R M 0.158 Neutral MSH6 P52701 R922N 922 R N 0.026 Neutral MSH6 P52701 R922P 922 R P 0.808 Pathogenic MSH6 P52701 R922Q 922 R Q 0.028 Neutral MSH6 P52701 R922S 922 R S 0.05 Neutral MSH6 P52701 R922T 922 R T 0.456 Neutral MSH6 P52701 R922V 922 R V 0.794 Pathogenic MSH6 P52701 R922W 922 R W 0.888 Pathogenic MSH6 P52701 R922Y 922 R Y 0.856 Pathogenic MSH6 P52701 K923A 923 K A 0.1 Neutral MSH6 P52701 K923C 923 K C 0.18 Neutral MSH6 P52701 K923D 923 K D 0.03 Neutral MSH6 P52701 K923E 923 K E 0.034 Neutral MSH6 P52701 K923F 923 K F 0.804 Pathogenic MSH6 P52701 K923G 923 K G 0.268 Neutral MSH6 P52701 K923H 923 K H 0.034 Neutral MSH6 P52701 K923I 923 K I 0.854 Pathogenic MSH6 P52701 K923L 923 K L 0.818 Pathogenic MSH6 P52701 K923M 923 K M 0.612 Pathogenic MSH6 P52701 K923N 923 K N 0.042 Neutral MSH6 P52701 K923P 923 K P 0.8 Pathogenic MSH6 P52701 K923Q 923 K Q 0.05 Neutral MSH6 P52701 K923R 923 K R 0.044 Neutral MSH6 P52701 K923S 923 K S 0.04 Neutral MSH6 P52701 K923T 923 K T 0.054 Neutral MSH6 P52701 K923V 923 K V 0.688 Pathogenic MSH6 P52701 K923W 923 K W 0.976 Pathogenic MSH6 P52701 K923Y 923 K Y 0.884 Pathogenic MSH6 P52701 T924A 924 T A 0.382 Neutral MSH6 P52701 T924C 924 T C 0.384 Neutral MSH6 P52701 T924D 924 T D 0.106 Neutral MSH6 P52701 T924E 924 T E 0.146 Neutral MSH6 P52701 T924F 924 T F 0.702 Pathogenic MSH6 P52701 T924G 924 T G 0.234 Neutral MSH6 P52701 T924H 924 T H 0.396 Neutral MSH6 P52701 T924I 924 T I 0.462 Neutral MSH6 P52701 T924K 924 T K 0.112 Neutral MSH6 P52701 T924L 924 T L 0.446 Neutral MSH6 P52701 T924M 924 T M 0.638 Pathogenic MSH6 P52701 T924N 924 T N 0.02 Neutral MSH6 P52701 T924P 924 T P 0.606 Pathogenic MSH6 P52701 T924Q 924 T Q 0.028 Neutral MSH6 P52701 T924R 924 T R 0.666 Pathogenic MSH6 P52701 T924S 924 T S 0.024 Neutral MSH6 P52701 T924V 924 T V 0.208 Neutral MSH6 P52701 T924W 924 T W 0.918 Pathogenic MSH6 P52701 T924Y 924 T Y 0.912 Pathogenic MSH6 P52701 G925A 925 G A 0.948 Pathogenic MSH6 P52701 G925C 925 G C 0.94 Pathogenic MSH6 P52701 G925D 925 G D 0.646 Pathogenic MSH6 P52701 G925E 925 G E 0.798 Pathogenic MSH6 P52701 G925F 925 G F 0.976 Pathogenic MSH6 P52701 G925H 925 G H 0.98 Pathogenic MSH6 P52701 G925I 925 G I 0.968 Pathogenic MSH6 P52701 G925K 925 G K 0.652 Pathogenic MSH6 P52701 G925L 925 G L 0.978 Pathogenic MSH6 P52701 G925M 925 G M 0.994 Pathogenic MSH6 P52701 G925N 925 G N 0.984 Pathogenic MSH6 P52701 G925P 925 G P 0.938 Pathogenic MSH6 P52701 G925Q 925 G Q 0.744 Pathogenic MSH6 P52701 G925R 925 G R 0.874 Pathogenic MSH6 P52701 G925S 925 G S 0.77 Pathogenic MSH6 P52701 G925T 925 G T 0.802 Pathogenic MSH6 P52701 G925V 925 G V 0.978 Pathogenic MSH6 P52701 G925W 925 G W 0.972 Pathogenic MSH6 P52701 G925Y 925 G Y 0.864 Pathogenic MSH6 P52701 L926A 926 L A 0.094 Neutral MSH6 P52701 L926C 926 L C 0.044 Neutral MSH6 P52701 L926D 926 L D 0.58 Pathogenic MSH6 P52701 L926E 926 L E 0.254 Neutral MSH6 P52701 L926F 926 L F 0.32 Neutral MSH6 P52701 L926G 926 L G 0.52 Pathogenic MSH6 P52701 L926H 926 L H 0.286 Neutral MSH6 P52701 L926I 926 L I 0.032 Neutral MSH6 P52701 L926K 926 L K 0.068 Neutral MSH6 P52701 L926M 926 L M 0.236 Neutral MSH6 P52701 L926N 926 L N 0.514 Pathogenic MSH6 P52701 L926P 926 L P 0.744 Pathogenic MSH6 P52701 L926Q 926 L Q 0.252 Neutral MSH6 P52701 L926R 926 L R 0.488 Neutral MSH6 P52701 L926S 926 L S 0.08 Neutral MSH6 P52701 L926T 926 L T 0.066 Neutral MSH6 P52701 L926V 926 L V 0.036 Neutral MSH6 P52701 L926W 926 L W 0.756 Pathogenic MSH6 P52701 L926Y 926 L Y 0.658 Pathogenic MSH6 P52701 I927A 927 I A 0.282 Neutral MSH6 P52701 I927C 927 I C 0.434 Neutral MSH6 P52701 I927D 927 I D 0.484 Neutral MSH6 P52701 I927E 927 I E 0.598 Pathogenic MSH6 P52701 I927F 927 I F 0.136 Neutral MSH6 P52701 I927G 927 I G 0.588 Pathogenic MSH6 P52701 I927H 927 I H 0.514 Pathogenic MSH6 P52701 I927K 927 I K 0.442 Neutral MSH6 P52701 I927L 927 I L 0.01 Neutral MSH6 P52701 I927M 927 I M 0.06 Neutral MSH6 P52701 I927N 927 I N 0.654 Pathogenic MSH6 P52701 I927P 927 I P 0.712 Pathogenic MSH6 P52701 I927Q 927 I Q 0.634 Pathogenic MSH6 P52701 I927R 927 I R 0.812 Pathogenic MSH6 P52701 I927S 927 I S 0.378 Neutral MSH6 P52701 I927T 927 I T 0.28 Neutral MSH6 P52701 I927V 927 I V 0.006 Neutral MSH6 P52701 I927W 927 I W 0.856 Pathogenic MSH6 P52701 I927Y 927 I Y 0.848 Pathogenic MSH6 P52701 T928A 928 T A 0.084 Neutral MSH6 P52701 T928C 928 T C 0.458 Neutral MSH6 P52701 T928D 928 T D 0.37 Neutral MSH6 P52701 T928E 928 T E 0.17 Neutral MSH6 P52701 T928F 928 T F 0.634 Pathogenic MSH6 P52701 T928G 928 T G 0.274 Neutral MSH6 P52701 T928H 928 T H 0.536 Pathogenic MSH6 P52701 T928I 928 T I 0.138 Neutral MSH6 P52701 T928K 928 T K 0.188 Neutral MSH6 P52701 T928L 928 T L 0.446 Neutral MSH6 P52701 T928M 928 T M 0.406 Neutral MSH6 P52701 T928N 928 T N 0.148 Neutral MSH6 P52701 T928P 928 T P 0.602 Pathogenic MSH6 P52701 T928Q 928 T Q 0.154 Neutral MSH6 P52701 T928R 928 T R 0.776 Pathogenic MSH6 P52701 T928S 928 T S 0.286 Neutral MSH6 P52701 T928V 928 T V 0.076 Neutral MSH6 P52701 T928W 928 T W 0.916 Pathogenic MSH6 P52701 T928Y 928 T Y 0.91 Pathogenic MSH6 P52701 P929A 929 P A 0.524 Pathogenic MSH6 P52701 P929C 929 P C 0.546 Pathogenic MSH6 P52701 P929D 929 P D 0.37 Neutral MSH6 P52701 P929E 929 P E 0.66 Pathogenic MSH6 P52701 P929F 929 P F 0.904 Pathogenic MSH6 P52701 P929G 929 P G 0.282 Neutral MSH6 P52701 P929H 929 P H 0.802 Pathogenic MSH6 P52701 P929I 929 P I 0.678 Pathogenic MSH6 P52701 P929K 929 P K 0.622 Pathogenic MSH6 P52701 P929L 929 P L 0.626 Pathogenic MSH6 P52701 P929M 929 P M 0.67 Pathogenic MSH6 P52701 P929N 929 P N 0.288 Neutral MSH6 P52701 P929Q 929 P Q 0.63 Pathogenic MSH6 P52701 P929R 929 P R 0.822 Pathogenic MSH6 P52701 P929S 929 P S 0.332 Neutral MSH6 P52701 P929T 929 P T 0.434 Neutral MSH6 P52701 P929V 929 P V 0.532 Pathogenic MSH6 P52701 P929W 929 P W 0.886 Pathogenic MSH6 P52701 P929Y 929 P Y 0.868 Pathogenic MSH6 P52701 G93A 93 G A 0.16 Neutral MSH6 P52701 G93C 93 G C 0.34 Neutral MSH6 P52701 G93D 93 G D 0.43 Neutral MSH6 P52701 G93E 93 G E 0.568 Pathogenic MSH6 P52701 G93F 93 G F 0.762 Pathogenic MSH6 P52701 G93H 93 G H 0.706 Pathogenic MSH6 P52701 G93I 93 G I 0.676 Pathogenic MSH6 P52701 G93K 93 G K 0.686 Pathogenic MSH6 P52701 G93L 93 G L 0.676 Pathogenic MSH6 P52701 G93M 93 G M 0.694 Pathogenic MSH6 P52701 G93N 93 G N 0.424 Neutral MSH6 P52701 G93P 93 G P 0.634 Pathogenic MSH6 P52701 G93Q 93 G Q 0.454 Neutral MSH6 P52701 G93R 93 G R 0.756 Pathogenic MSH6 P52701 G93S 93 G S 0.284 Neutral MSH6 P52701 G93T 93 G T 0.466 Neutral MSH6 P52701 G93V 93 G V 0.656 Pathogenic MSH6 P52701 G93W 93 G W 0.76 Pathogenic MSH6 P52701 G93Y 93 G Y 0.744 Pathogenic MSH6 P52701 K930A 930 K A 0.106 Neutral MSH6 P52701 K930C 930 K C 0.014 Neutral MSH6 P52701 K930D 930 K D 0.102 Neutral MSH6 P52701 K930E 930 K E 0.006 Neutral MSH6 P52701 K930F 930 K F 0.368 Neutral MSH6 P52701 K930G 930 K G 0.134 Neutral MSH6 P52701 K930H 930 K H 0.086 Neutral MSH6 P52701 K930I 930 K I 0.4 Neutral MSH6 P52701 K930L 930 K L 0.306 Neutral MSH6 P52701 K930M 930 K M 0.24 Neutral MSH6 P52701 K930N 930 K N 0.01 Neutral MSH6 P52701 K930P 930 K P 0.392 Neutral MSH6 P52701 K930Q 930 K Q 0.012 Neutral MSH6 P52701 K930R 930 K R 0.008 Neutral MSH6 P52701 K930S 930 K S 0.018 Neutral MSH6 P52701 K930T 930 K T 0.15 Neutral MSH6 P52701 K930V 930 K V 0.306 Neutral MSH6 P52701 K930W 930 K W 0.682 Pathogenic MSH6 P52701 K930Y 930 K Y 0.586 Pathogenic MSH6 P52701 A931C 931 A C 0.204 Neutral MSH6 P52701 A931D 931 A D 0.316 Neutral MSH6 P52701 A931E 931 A E 0.3 Neutral MSH6 P52701 A931F 931 A F 0.526 Pathogenic MSH6 P52701 A931G 931 A G 0.162 Neutral MSH6 P52701 A931H 931 A H 0.308 Neutral MSH6 P52701 A931I 931 A I 0.46 Neutral MSH6 P52701 A931K 931 A K 0.294 Neutral MSH6 P52701 A931L 931 A L 0.384 Neutral MSH6 P52701 A931M 931 A M 0.338 Neutral MSH6 P52701 A931N 931 A N 0.322 Neutral MSH6 P52701 A931P 931 A P 0.044 Neutral MSH6 P52701 A931Q 931 A Q 0.332 Neutral MSH6 P52701 A931R 931 A R 0.316 Neutral MSH6 P52701 A931S 931 A S 0.008 Neutral MSH6 P52701 A931T 931 A T 0.016 Neutral MSH6 P52701 A931V 931 A V 0.044 Neutral MSH6 P52701 A931W 931 A W 0.56 Pathogenic MSH6 P52701 A931Y 931 A Y 0.558 Pathogenic MSH6 P52701 G932A 932 G A 0.966 Pathogenic MSH6 P52701 G932C 932 G C 0.948 Pathogenic MSH6 P52701 G932D 932 G D 1 Pathogenic MSH6 P52701 G932E 932 G E 0.988 Pathogenic MSH6 P52701 G932F 932 G F 0.982 Pathogenic MSH6 P52701 G932H 932 G H 0.986 Pathogenic MSH6 P52701 G932I 932 G I 0.972 Pathogenic MSH6 P52701 G932K 932 G K 0.926 Pathogenic MSH6 P52701 G932L 932 G L 0.982 Pathogenic MSH6 P52701 G932M 932 G M 0.994 Pathogenic MSH6 P52701 G932N 932 G N 0.986 Pathogenic MSH6 P52701 G932P 932 G P 0.964 Pathogenic MSH6 P52701 G932Q 932 G Q 0.994 Pathogenic MSH6 P52701 G932R 932 G R 1 Pathogenic MSH6 P52701 G932S 932 G S 0.648 Pathogenic MSH6 P52701 G932T 932 G T 0.84 Pathogenic MSH6 P52701 G932V 932 G V 0.984 Pathogenic MSH6 P52701 G932W 932 G W 0.978 Pathogenic MSH6 P52701 G932Y 932 G Y 0.958 Pathogenic MSH6 P52701 F933A 933 F A 0.13 Neutral MSH6 P52701 F933C 933 F C 0.042 Neutral MSH6 P52701 F933D 933 F D 0.54 Pathogenic MSH6 P52701 F933E 933 F E 0.624 Pathogenic MSH6 P52701 F933G 933 F G 0.132 Neutral MSH6 P52701 F933H 933 F H 0.172 Neutral MSH6 P52701 F933I 933 F I 0.048 Neutral MSH6 P52701 F933K 933 F K 0.576 Pathogenic MSH6 P52701 F933L 933 F L 0.04 Neutral MSH6 P52701 F933M 933 F M 0.038 Neutral MSH6 P52701 F933N 933 F N 0.53 Pathogenic MSH6 P52701 F933P 933 F P 0.74 Pathogenic MSH6 P52701 F933Q 933 F Q 0.16 Neutral MSH6 P52701 F933R 933 F R 0.528 Pathogenic MSH6 P52701 F933S 933 F S 0.43 Neutral MSH6 P52701 F933T 933 F T 0.06 Neutral MSH6 P52701 F933V 933 F V 0.088 Neutral MSH6 P52701 F933W 933 F W 0.862 Pathogenic MSH6 P52701 F933Y 933 F Y 0.57 Pathogenic MSH6 P52701 D934A 934 D A 0.672 Pathogenic MSH6 P52701 D934C 934 D C 0.908 Pathogenic MSH6 P52701 D934E 934 D E 0.238 Neutral MSH6 P52701 D934F 934 D F 0.606 Pathogenic MSH6 P52701 D934G 934 D G 0.888 Pathogenic MSH6 P52701 D934H 934 D H 0.622 Pathogenic MSH6 P52701 D934I 934 D I 0.418 Neutral MSH6 P52701 D934K 934 D K 0.972 Pathogenic MSH6 P52701 D934L 934 D L 0.978 Pathogenic MSH6 P52701 D934M 934 D M 0.946 Pathogenic MSH6 P52701 D934N 934 D N 0.096 Neutral MSH6 P52701 D934P 934 D P 0.908 Pathogenic MSH6 P52701 D934Q 934 D Q 0.768 Pathogenic MSH6 P52701 D934R 934 D R 0.906 Pathogenic MSH6 P52701 D934S 934 D S 0.168 Neutral MSH6 P52701 D934T 934 D T 0.83 Pathogenic MSH6 P52701 D934V 934 D V 0.992 Pathogenic MSH6 P52701 D934W 934 D W 0.986 Pathogenic MSH6 P52701 D934Y 934 D Y 0.93 Pathogenic MSH6 P52701 S935A 935 S A 0.076 Neutral MSH6 P52701 S935C 935 S C 0.412 Neutral MSH6 P52701 S935D 935 S D 0.092 Neutral MSH6 P52701 S935E 935 S E 0.42 Neutral MSH6 P52701 S935F 935 S F 0.776 Pathogenic MSH6 P52701 S935G 935 S G 0.346 Neutral MSH6 P52701 S935H 935 S H 0.574 Pathogenic MSH6 P52701 S935I 935 S I 0.35 Neutral MSH6 P52701 S935K 935 S K 0.432 Neutral MSH6 P52701 S935L 935 S L 0.518 Pathogenic MSH6 P52701 S935M 935 S M 0.728 Pathogenic MSH6 P52701 S935N 935 S N 0.286 Neutral MSH6 P52701 S935P 935 S P 0.168 Neutral MSH6 P52701 S935Q 935 S Q 0.452 Neutral MSH6 P52701 S935R 935 S R 0.476 Neutral MSH6 P52701 S935T 935 S T 0.076 Neutral MSH6 P52701 S935V 935 S V 0.134 Neutral MSH6 P52701 S935W 935 S W 0.928 Pathogenic MSH6 P52701 S935Y 935 S Y 0.902 Pathogenic MSH6 P52701 D936A 936 D A 0.34 Neutral MSH6 P52701 D936C 936 D C 0.906 Pathogenic MSH6 P52701 D936E 936 D E 0.334 Neutral MSH6 P52701 D936F 936 D F 0.984 Pathogenic MSH6 P52701 D936G 936 D G 0.892 Pathogenic MSH6 P52701 D936H 936 D H 0.626 Pathogenic MSH6 P52701 D936I 936 D I 0.968 Pathogenic MSH6 P52701 D936K 936 D K 0.972 Pathogenic MSH6 P52701 D936L 936 D L 0.768 Pathogenic MSH6 P52701 D936M 936 D M 0.946 Pathogenic MSH6 P52701 D936N 936 D N 0.138 Neutral MSH6 P52701 D936P 936 D P 0.704 Pathogenic MSH6 P52701 D936Q 936 D Q 0.192 Neutral MSH6 P52701 D936R 936 D R 0.906 Pathogenic MSH6 P52701 D936S 936 D S 0.166 Neutral MSH6 P52701 D936T 936 D T 0.832 Pathogenic MSH6 P52701 D936V 936 D V 0.772 Pathogenic MSH6 P52701 D936W 936 D W 0.986 Pathogenic MSH6 P52701 D936Y 936 D Y 0.98 Pathogenic MSH6 P52701 Y937A 937 Y A 0.412 Neutral MSH6 P52701 Y937C 937 Y C 0.644 Pathogenic MSH6 P52701 Y937D 937 Y D 0.8 Pathogenic MSH6 P52701 Y937E 937 Y E 0.708 Pathogenic MSH6 P52701 Y937F 937 Y F 0.118 Neutral MSH6 P52701 Y937G 937 Y G 0.462 Neutral MSH6 P52701 Y937H 937 Y H 0.578 Pathogenic MSH6 P52701 Y937I 937 Y I 0.784 Pathogenic MSH6 P52701 Y937K 937 Y K 0.812 Pathogenic MSH6 P52701 Y937L 937 Y L 0.23 Neutral MSH6 P52701 Y937M 937 Y M 0.662 Pathogenic MSH6 P52701 Y937N 937 Y N 0.692 Pathogenic MSH6 P52701 Y937P 937 Y P 0.78 Pathogenic MSH6 P52701 Y937Q 937 Y Q 0.602 Pathogenic MSH6 P52701 Y937R 937 Y R 0.73 Pathogenic MSH6 P52701 Y937S 937 Y S 0.46 Neutral MSH6 P52701 Y937T 937 Y T 0.638 Pathogenic MSH6 P52701 Y937V 937 Y V 0.764 Pathogenic MSH6 P52701 Y937W 937 Y W 0.468 Neutral MSH6 P52701 D938A 938 D A 0.568 Pathogenic MSH6 P52701 D938C 938 D C 0.878 Pathogenic MSH6 P52701 D938E 938 D E 0.81 Pathogenic MSH6 P52701 D938F 938 D F 0.98 Pathogenic MSH6 P52701 D938G 938 D G 0.932 Pathogenic MSH6 P52701 D938H 938 D H 0.626 Pathogenic MSH6 P52701 D938I 938 D I 0.974 Pathogenic MSH6 P52701 D938K 938 D K 0.924 Pathogenic MSH6 P52701 D938L 938 D L 0.976 Pathogenic MSH6 P52701 D938M 938 D M 0.956 Pathogenic MSH6 P52701 D938N 938 D N 0.43 Neutral MSH6 P52701 D938P 938 D P 0.904 Pathogenic MSH6 P52701 D938Q 938 D Q 0.616 Pathogenic MSH6 P52701 D938R 938 D R 0.958 Pathogenic MSH6 P52701 D938S 938 D S 0.562 Pathogenic MSH6 P52701 D938T 938 D T 0.796 Pathogenic MSH6 P52701 D938V 938 D V 0.996 Pathogenic MSH6 P52701 D938W 938 D W 0.98 Pathogenic MSH6 P52701 D938Y 938 D Y 0.974 Pathogenic MSH6 P52701 Q939A 939 Q A 0.066 Neutral MSH6 P52701 Q939C 939 Q C 0.178 Neutral MSH6 P52701 Q939D 939 Q D 0.002 Neutral MSH6 P52701 Q939E 939 Q E 0.018 Neutral MSH6 P52701 Q939F 939 Q F 0.336 Neutral MSH6 P52701 Q939G 939 Q G 0.072 Neutral MSH6 P52701 Q939H 939 Q H 0.588 Pathogenic MSH6 P52701 Q939I 939 Q I 0.62 Pathogenic MSH6 P52701 Q939K 939 Q K 0.036 Neutral MSH6 P52701 Q939L 939 Q L 0.16 Neutral MSH6 P52701 Q939M 939 Q M 0.48 Neutral MSH6 P52701 Q939N 939 Q N 0.028 Neutral MSH6 P52701 Q939P 939 Q P 0.632 Pathogenic MSH6 P52701 Q939R 939 Q R 0.014 Neutral MSH6 P52701 Q939S 939 Q S 0.066 Neutral MSH6 P52701 Q939T 939 Q T 0.02 Neutral MSH6 P52701 Q939V 939 Q V 0.13 Neutral MSH6 P52701 Q939W 939 Q W 0.804 Pathogenic MSH6 P52701 Q939Y 939 Q Y 0.726 Pathogenic MSH6 P52701 D94A 94 D A 0.018 Neutral MSH6 P52701 D94C 94 D C 0.24 Neutral MSH6 P52701 D94E 94 D E 0.114 Neutral MSH6 P52701 D94F 94 D F 0.588 Pathogenic MSH6 P52701 D94G 94 D G 0.192 Neutral MSH6 P52701 D94H 94 D H 0.154 Neutral MSH6 P52701 D94I 94 D I 0.406 Neutral MSH6 P52701 D94K 94 D K 0.284 Neutral MSH6 P52701 D94L 94 D L 0.4 Neutral MSH6 P52701 D94M 94 D M 0.31 Neutral MSH6 P52701 D94N 94 D N 0.09 Neutral MSH6 P52701 D94P 94 D P 0.422 Neutral MSH6 P52701 D94Q 94 D Q 0.168 Neutral MSH6 P52701 D94R 94 D R 0.32 Neutral MSH6 P52701 D94S 94 D S 0.084 Neutral MSH6 P52701 D94T 94 D T 0.18 Neutral MSH6 P52701 D94V 94 D V 0.398 Neutral MSH6 P52701 D94W 94 D W 0.67 Pathogenic MSH6 P52701 D94Y 94 D Y 0.644 Pathogenic MSH6 P52701 A940C 940 A C 0.43 Neutral MSH6 P52701 A940D 940 A D 0.928 Pathogenic MSH6 P52701 A940E 940 A E 0.956 Pathogenic MSH6 P52701 A940F 940 A F 0.982 Pathogenic MSH6 P52701 A940G 940 A G 0.358 Neutral MSH6 P52701 A940H 940 A H 0.912 Pathogenic MSH6 P52701 A940I 940 A I 0.74 Pathogenic MSH6 P52701 A940K 940 A K 0.95 Pathogenic MSH6 P52701 A940L 940 A L 0.984 Pathogenic MSH6 P52701 A940M 940 A M 0.878 Pathogenic MSH6 P52701 A940N 940 A N 0.868 Pathogenic MSH6 P52701 A940P 940 A P 0.958 Pathogenic MSH6 P52701 A940Q 940 A Q 0.654 Pathogenic MSH6 P52701 A940R 940 A R 0.958 Pathogenic MSH6 P52701 A940S 940 A S 0.144 Neutral MSH6 P52701 A940T 940 A T 0.214 Neutral MSH6 P52701 A940V 940 A V 0.436 Neutral MSH6 P52701 A940W 940 A W 0.982 Pathogenic MSH6 P52701 A940Y 940 A Y 0.948 Pathogenic MSH6 P52701 L941A 941 L A 0.032 Neutral MSH6 P52701 L941C 941 L C 0.01 Neutral MSH6 P52701 L941D 941 L D 0.252 Neutral MSH6 P52701 L941E 941 L E 0.04 Neutral MSH6 P52701 L941F 941 L F 0.382 Neutral MSH6 P52701 L941G 941 L G 0.29 Neutral MSH6 P52701 L941H 941 L H 0.088 Neutral MSH6 P52701 L941I 941 L I 0.002 Neutral MSH6 P52701 L941K 941 L K 0.054 Neutral MSH6 P52701 L941M 941 L M 0.012 Neutral MSH6 P52701 L941N 941 L N 0.04 Neutral MSH6 P52701 L941P 941 L P 0.344 Neutral MSH6 P52701 L941Q 941 L Q 0.01 Neutral MSH6 P52701 L941R 941 L R 0.508 Pathogenic MSH6 P52701 L941S 941 L S 0.042 Neutral MSH6 P52701 L941T 941 L T 0.046 Neutral MSH6 P52701 L941V 941 L V 0.002 Neutral MSH6 P52701 L941W 941 L W 0.572 Pathogenic MSH6 P52701 L941Y 941 L Y 0.532 Pathogenic MSH6 P52701 A942C 942 A C 0.22 Neutral MSH6 P52701 A942D 942 A D 0.45 Neutral MSH6 P52701 A942E 942 A E 0.378 Neutral MSH6 P52701 A942F 942 A F 0.708 Pathogenic MSH6 P52701 A942G 942 A G 0.014 Neutral MSH6 P52701 A942H 942 A H 0.5 Pathogenic MSH6 P52701 A942I 942 A I 0.456 Neutral MSH6 P52701 A942K 942 A K 0.364 Neutral MSH6 P52701 A942L 942 A L 0.65 Pathogenic MSH6 P52701 A942M 942 A M 0.346 Neutral MSH6 P52701 A942N 942 A N 0.398 Neutral MSH6 P52701 A942P 942 A P 0.48 Neutral MSH6 P52701 A942Q 942 A Q 0.34 Neutral MSH6 P52701 A942R 942 A R 0.402 Neutral MSH6 P52701 A942S 942 A S 0.012 Neutral MSH6 P52701 A942T 942 A T 0.03 Neutral MSH6 P52701 A942V 942 A V 0.11 Neutral MSH6 P52701 A942W 942 A W 0.738 Pathogenic MSH6 P52701 A942Y 942 A Y 0.724 Pathogenic MSH6 P52701 D943A 943 D A 0.02 Neutral MSH6 P52701 D943C 943 D C 0.242 Neutral MSH6 P52701 D943E 943 D E 0.012 Neutral MSH6 P52701 D943F 943 D F 0.612 Pathogenic MSH6 P52701 D943G 943 D G 0.02 Neutral MSH6 P52701 D943H 943 D H 0.142 Neutral MSH6 P52701 D943I 943 D I 0.428 Neutral MSH6 P52701 D943K 943 D K 0.026 Neutral MSH6 P52701 D943L 943 D L 0.094 Neutral MSH6 P52701 D943M 943 D M 0.322 Neutral MSH6 P52701 D943N 943 D N 0 Neutral MSH6 P52701 D943P 943 D P 0.436 Neutral MSH6 P52701 D943Q 943 D Q 0.164 Neutral MSH6 P52701 D943R 943 D R 0.252 Neutral MSH6 P52701 D943S 943 D S 0.002 Neutral MSH6 P52701 D943T 943 D T 0.232 Neutral MSH6 P52701 D943V 943 D V 0.42 Neutral MSH6 P52701 D943W 943 D W 0.698 Pathogenic MSH6 P52701 D943Y 943 D Y 0.67 Pathogenic MSH6 P52701 I944A 944 I A 0.472 Neutral MSH6 P52701 I944C 944 I C 0.61 Pathogenic MSH6 P52701 I944D 944 I D 0.762 Pathogenic MSH6 P52701 I944E 944 I E 0.484 Neutral MSH6 P52701 I944F 944 I F 0.584 Pathogenic MSH6 P52701 I944G 944 I G 0.81 Pathogenic MSH6 P52701 I944H 944 I H 0.842 Pathogenic MSH6 P52701 I944K 944 I K 0.854 Pathogenic MSH6 P52701 I944L 944 I L 0.084 Neutral MSH6 P52701 I944M 944 I M 0.168 Neutral MSH6 P52701 I944N 944 I N 0.788 Pathogenic MSH6 P52701 I944P 944 I P 0.302 Neutral MSH6 P52701 I944Q 944 I Q 0.216 Neutral MSH6 P52701 I944R 944 I R 0.882 Pathogenic MSH6 P52701 I944S 944 I S 0.628 Pathogenic MSH6 P52701 I944T 944 I T 0.366 Neutral MSH6 P52701 I944V 944 I V 0.124 Neutral MSH6 P52701 I944W 944 I W 0.988 Pathogenic MSH6 P52701 I944Y 944 I Y 0.984 Pathogenic MSH6 P52701 R945A 945 R A 0.086 Neutral MSH6 P52701 R945C 945 R C 0.592 Pathogenic MSH6 P52701 R945D 945 R D 0.03 Neutral MSH6 P52701 R945E 945 R E 0.04 Neutral MSH6 P52701 R945F 945 R F 0.858 Pathogenic MSH6 P52701 R945G 945 R G 0.02 Neutral MSH6 P52701 R945H 945 R H 0.112 Neutral MSH6 P52701 R945I 945 R I 0.874 Pathogenic MSH6 P52701 R945K 945 R K 0.052 Neutral MSH6 P52701 R945L 945 R L 0.782 Pathogenic MSH6 P52701 R945M 945 R M 0.626 Pathogenic MSH6 P52701 R945N 945 R N 0.022 Neutral MSH6 P52701 R945P 945 R P 0.796 Pathogenic MSH6 P52701 R945Q 945 R Q 0.02 Neutral MSH6 P52701 R945S 945 R S 0.038 Neutral MSH6 P52701 R945T 945 R T 0.052 Neutral MSH6 P52701 R945V 945 R V 0.226 Neutral MSH6 P52701 R945W 945 R W 0.856 Pathogenic MSH6 P52701 R945Y 945 R Y 0.818 Pathogenic MSH6 P52701 E946A 946 E A 0.256 Neutral MSH6 P52701 E946C 946 E C 0.466 Neutral MSH6 P52701 E946D 946 E D 0.044 Neutral MSH6 P52701 E946F 946 E F 0.842 Pathogenic MSH6 P52701 E946G 946 E G 0.052 Neutral MSH6 P52701 E946H 946 E H 0.388 Neutral MSH6 P52701 E946I 946 E I 0.884 Pathogenic MSH6 P52701 E946K 946 E K 0.096 Neutral MSH6 P52701 E946L 946 E L 0.836 Pathogenic MSH6 P52701 E946M 946 E M 0.684 Pathogenic MSH6 P52701 E946N 946 E N 0.05 Neutral MSH6 P52701 E946P 946 E P 0.874 Pathogenic MSH6 P52701 E946Q 946 E Q 0.036 Neutral MSH6 P52701 E946R 946 E R 0.144 Neutral MSH6 P52701 E946S 946 E S 0.068 Neutral MSH6 P52701 E946T 946 E T 0.07 Neutral MSH6 P52701 E946V 946 E V 0.51 Pathogenic MSH6 P52701 E946W 946 E W 0.968 Pathogenic MSH6 P52701 E946Y 946 E Y 0.91 Pathogenic MSH6 P52701 N947A 947 N A 0.068 Neutral MSH6 P52701 N947C 947 N C 0.044 Neutral MSH6 P52701 N947D 947 N D 0.564 Pathogenic MSH6 P52701 N947E 947 N E 0.528 Pathogenic MSH6 P52701 N947F 947 N F 0.912 Pathogenic MSH6 P52701 N947G 947 N G 0.616 Pathogenic MSH6 P52701 N947H 947 N H 0.752 Pathogenic MSH6 P52701 N947I 947 N I 0.37 Neutral MSH6 P52701 N947K 947 N K 0.442 Neutral MSH6 P52701 N947L 947 N L 0.154 Neutral MSH6 P52701 N947M 947 N M 0.83 Pathogenic MSH6 P52701 N947P 947 N P 0.754 Pathogenic MSH6 P52701 N947Q 947 N Q 0.622 Pathogenic MSH6 P52701 N947R 947 N R 0.446 Neutral MSH6 P52701 N947S 947 N S 0.124 Neutral MSH6 P52701 N947T 947 N T 0.04 Neutral MSH6 P52701 N947V 947 N V 0.09 Neutral MSH6 P52701 N947W 947 N W 0.954 Pathogenic MSH6 P52701 N947Y 947 N Y 0.946 Pathogenic MSH6 P52701 E948A 948 E A 0.578 Pathogenic MSH6 P52701 E948C 948 E C 0.492 Neutral MSH6 P52701 E948D 948 E D 0.272 Neutral MSH6 P52701 E948F 948 E F 0.88 Pathogenic MSH6 P52701 E948G 948 E G 0.076 Neutral MSH6 P52701 E948H 948 E H 0.064 Neutral MSH6 P52701 E948I 948 E I 0.24 Neutral MSH6 P52701 E948K 948 E K 0.052 Neutral MSH6 P52701 E948L 948 E L 0.138 Neutral MSH6 P52701 E948M 948 E M 0.112 Neutral MSH6 P52701 E948N 948 E N 0.036 Neutral MSH6 P52701 E948P 948 E P 0.89 Pathogenic MSH6 P52701 E948Q 948 E Q 0.034 Neutral MSH6 P52701 E948R 948 E R 0.164 Neutral MSH6 P52701 E948S 948 E S 0.53 Pathogenic MSH6 P52701 E948T 948 E T 0.252 Neutral MSH6 P52701 E948V 948 E V 0.422 Neutral MSH6 P52701 E948W 948 E W 0.972 Pathogenic MSH6 P52701 E948Y 948 E Y 0.92 Pathogenic MSH6 P52701 Q949A 949 Q A 0.056 Neutral MSH6 P52701 Q949C 949 Q C 0.17 Neutral MSH6 P52701 Q949D 949 Q D 0 Neutral MSH6 P52701 Q949E 949 Q E 0.008 Neutral MSH6 P52701 Q949F 949 Q F 0.446 Neutral MSH6 P52701 Q949G 949 Q G 0.05 Neutral MSH6 P52701 Q949H 949 Q H 0.04 Neutral MSH6 P52701 Q949I 949 Q I 0.382 Neutral MSH6 P52701 Q949K 949 Q K 0.024 Neutral MSH6 P52701 Q949L 949 Q L 0.142 Neutral MSH6 P52701 Q949M 949 Q M 0.18 Neutral MSH6 P52701 Q949N 949 Q N 0.024 Neutral MSH6 P52701 Q949P 949 Q P 0.492 Neutral MSH6 P52701 Q949R 949 Q R 0.008 Neutral MSH6 P52701 Q949S 949 Q S 0.05 Neutral MSH6 P52701 Q949T 949 Q T 0.004 Neutral MSH6 P52701 Q949V 949 Q V 0.192 Neutral MSH6 P52701 Q949W 949 Q W 0.742 Pathogenic MSH6 P52701 Q949Y 949 Q Y 0.464 Neutral MSH6 P52701 L95A 95 L A 0.132 Neutral MSH6 P52701 L95C 95 L C 0.136 Neutral MSH6 P52701 L95D 95 L D 0.25 Neutral MSH6 P52701 L95E 95 L E 0.232 Neutral MSH6 P52701 L95F 95 L F 0.374 Neutral MSH6 P52701 L95G 95 L G 0.264 Neutral MSH6 P52701 L95H 95 L H 0.128 Neutral MSH6 P52701 L95I 95 L I 0.044 Neutral MSH6 P52701 L95K 95 L K 0.182 Neutral MSH6 P52701 L95M 95 L M 0.192 Neutral MSH6 P52701 L95N 95 L N 0.242 Neutral MSH6 P52701 L95P 95 L P 0.344 Neutral MSH6 P52701 L95Q 95 L Q 0.104 Neutral MSH6 P52701 L95R 95 L R 0.504 Pathogenic MSH6 P52701 L95S 95 L S 0.198 Neutral MSH6 P52701 L95T 95 L T 0.178 Neutral MSH6 P52701 L95V 95 L V 0.096 Neutral MSH6 P52701 L95W 95 L W 0.536 Pathogenic MSH6 P52701 L95Y 95 L Y 0.498 Neutral MSH6 P52701 S950A 950 S A 0.372 Neutral MSH6 P52701 S950C 950 S C 0.294 Neutral MSH6 P52701 S950D 950 S D 0.104 Neutral MSH6 P52701 S950E 950 S E 0.44 Neutral MSH6 P52701 S950F 950 S F 0.786 Pathogenic MSH6 P52701 S950G 950 S G 0.068 Neutral MSH6 P52701 S950H 950 S H 0.586 Pathogenic MSH6 P52701 S950I 950 S I 0.55 Pathogenic MSH6 P52701 S950K 950 S K 0.442 Neutral MSH6 P52701 S950L 950 S L 0.39 Neutral MSH6 P52701 S950M 950 S M 0.946 Pathogenic MSH6 P52701 S950N 950 S N 0.058 Neutral MSH6 P52701 S950P 950 S P 0.576 Pathogenic MSH6 P52701 S950Q 950 S Q 0.456 Neutral MSH6 P52701 S950R 950 S R 0.466 Neutral MSH6 P52701 S950T 950 S T 0.66 Pathogenic MSH6 P52701 S950V 950 S V 0.77 Pathogenic MSH6 P52701 S950W 950 S W 0.932 Pathogenic MSH6 P52701 S950Y 950 S Y 0.912 Pathogenic MSH6 P52701 L951A 951 L A 0.19 Neutral MSH6 P52701 L951C 951 L C 0.81 Pathogenic MSH6 P52701 L951D 951 L D 0.878 Pathogenic MSH6 P52701 L951E 951 L E 0.858 Pathogenic MSH6 P52701 L951F 951 L F 0.446 Neutral MSH6 P52701 L951G 951 L G 0.844 Pathogenic MSH6 P52701 L951H 951 L H 0.904 Pathogenic MSH6 P52701 L951I 951 L I 0.508 Pathogenic MSH6 P52701 L951K 951 L K 0.696 Pathogenic MSH6 P52701 L951M 951 L M 0.154 Neutral MSH6 P52701 L951N 951 L N 0.776 Pathogenic MSH6 P52701 L951P 951 L P 0.97 Pathogenic MSH6 P52701 L951Q 951 L Q 0.742 Pathogenic MSH6 P52701 L951R 951 L R 0.974 Pathogenic MSH6 P52701 L951S 951 L S 0.142 Neutral MSH6 P52701 L951T 951 L T 0.586 Pathogenic MSH6 P52701 L951V 951 L V 0.362 Neutral MSH6 P52701 L951W 951 L W 0.838 Pathogenic MSH6 P52701 L951Y 951 L Y 0.86 Pathogenic MSH6 P52701 L952A 952 L A 0.058 Neutral MSH6 P52701 L952C 952 L C 0.3 Neutral MSH6 P52701 L952D 952 L D 0.1 Neutral MSH6 P52701 L952E 952 L E 0.092 Neutral MSH6 P52701 L952F 952 L F 0.648 Pathogenic MSH6 P52701 L952G 952 L G 0.588 Pathogenic MSH6 P52701 L952H 952 L H 0.038 Neutral MSH6 P52701 L952I 952 L I 0.316 Neutral MSH6 P52701 L952K 952 L K 0.068 Neutral MSH6 P52701 L952M 952 L M 0.244 Neutral MSH6 P52701 L952N 952 L N 0.092 Neutral MSH6 P52701 L952P 952 L P 0.706 Pathogenic MSH6 P52701 L952Q 952 L Q 0.052 Neutral MSH6 P52701 L952R 952 L R 0.488 Neutral MSH6 P52701 L952S 952 L S 0.128 Neutral MSH6 P52701 L952T 952 L T 0.074 Neutral MSH6 P52701 L952V 952 L V 0.566 Pathogenic MSH6 P52701 L952W 952 L W 0.766 Pathogenic MSH6 P52701 L952Y 952 L Y 0.664 Pathogenic MSH6 P52701 E953A 953 E A 0.16 Neutral MSH6 P52701 E953C 953 E C 0.36 Neutral MSH6 P52701 E953D 953 E D 0.028 Neutral MSH6 P52701 E953F 953 E F 0.748 Pathogenic MSH6 P52701 E953G 953 E G 0.066 Neutral MSH6 P52701 E953H 953 E H 0.624 Pathogenic MSH6 P52701 E953I 953 E I 0.558 Pathogenic MSH6 P52701 E953K 953 E K 0.034 Neutral MSH6 P52701 E953L 953 E L 0.116 Neutral MSH6 P52701 E953M 953 E M 0.648 Pathogenic MSH6 P52701 E953N 953 E N 0.028 Neutral MSH6 P52701 E953P 953 E P 0.814 Pathogenic MSH6 P52701 E953Q 953 E Q 0.026 Neutral MSH6 P52701 E953R 953 E R 0.08 Neutral MSH6 P52701 E953S 953 E S 0.056 Neutral MSH6 P52701 E953T 953 E T 0.06 Neutral MSH6 P52701 E953V 953 E V 0.078 Neutral MSH6 P52701 E953W 953 E W 0.9 Pathogenic MSH6 P52701 E953Y 953 E Y 0.816 Pathogenic MSH6 P52701 Y954A 954 Y A 0.334 Neutral MSH6 P52701 Y954C 954 Y C 0.542 Pathogenic MSH6 P52701 Y954D 954 Y D 0.79 Pathogenic MSH6 P52701 Y954E 954 Y E 0.424 Neutral MSH6 P52701 Y954F 954 Y F 0.094 Neutral MSH6 P52701 Y954G 954 Y G 0.382 Neutral MSH6 P52701 Y954H 954 Y H 0.08 Neutral MSH6 P52701 Y954I 954 Y I 0.676 Pathogenic MSH6 P52701 Y954K 954 Y K 0.804 Pathogenic MSH6 P52701 Y954L 954 Y L 0.112 Neutral MSH6 P52701 Y954M 954 Y M 0.176 Neutral MSH6 P52701 Y954N 954 Y N 0.616 Pathogenic MSH6 P52701 Y954P 954 Y P 0.702 Pathogenic MSH6 P52701 Y954Q 954 Y Q 0.528 Pathogenic MSH6 P52701 Y954R 954 Y R 0.742 Pathogenic MSH6 P52701 Y954S 954 Y S 0.376 Neutral MSH6 P52701 Y954T 954 Y T 0.534 Pathogenic MSH6 P52701 Y954V 954 Y V 0.162 Neutral MSH6 P52701 Y954W 954 Y W 0.79 Pathogenic MSH6 P52701 L955A 955 L A 0.702 Pathogenic MSH6 P52701 L955C 955 L C 0.806 Pathogenic MSH6 P52701 L955D 955 L D 0.882 Pathogenic MSH6 P52701 L955E 955 L E 0.526 Pathogenic MSH6 P52701 L955F 955 L F 0.828 Pathogenic MSH6 P52701 L955G 955 L G 0.856 Pathogenic MSH6 P52701 L955H 955 L H 0.898 Pathogenic MSH6 P52701 L955I 955 L I 0.52 Pathogenic MSH6 P52701 L955K 955 L K 0.148 Neutral MSH6 P52701 L955M 955 L M 0.56 Pathogenic MSH6 P52701 L955N 955 L N 0.794 Pathogenic MSH6 P52701 L955P 955 L P 0.966 Pathogenic MSH6 P52701 L955Q 955 L Q 0.756 Pathogenic MSH6 P52701 L955R 955 L R 0.542 Pathogenic MSH6 P52701 L955S 955 L S 0.678 Pathogenic MSH6 P52701 L955T 955 L T 0.596 Pathogenic MSH6 P52701 L955V 955 L V 0.354 Neutral MSH6 P52701 L955W 955 L W 0.846 Pathogenic MSH6 P52701 L955Y 955 L Y 0.762 Pathogenic MSH6 P52701 E956A 956 E A 0.238 Neutral MSH6 P52701 E956C 956 E C 0.444 Neutral MSH6 P52701 E956D 956 E D 0.028 Neutral MSH6 P52701 E956F 956 E F 0.804 Pathogenic MSH6 P52701 E956G 956 E G 0.128 Neutral MSH6 P52701 E956H 956 E H 0.084 Neutral MSH6 P52701 E956I 956 E I 0.37 Neutral MSH6 P52701 E956K 956 E K 0.052 Neutral MSH6 P52701 E956L 956 E L 0.174 Neutral MSH6 P52701 E956M 956 E M 0.66 Pathogenic MSH6 P52701 E956N 956 E N 0.032 Neutral MSH6 P52701 E956P 956 E P 0.856 Pathogenic MSH6 P52701 E956Q 956 E Q 0.024 Neutral MSH6 P52701 E956R 956 E R 0.13 Neutral MSH6 P52701 E956S 956 E S 0.042 Neutral MSH6 P52701 E956T 956 E T 0.058 Neutral MSH6 P52701 E956V 956 E V 0.116 Neutral MSH6 P52701 E956W 956 E W 0.944 Pathogenic MSH6 P52701 E956Y 956 E Y 0.87 Pathogenic MSH6 P52701 K957A 957 K A 0.106 Neutral MSH6 P52701 K957C 957 K C 0.206 Neutral MSH6 P52701 K957D 957 K D 0.016 Neutral MSH6 P52701 K957E 957 K E 0.012 Neutral MSH6 P52701 K957F 957 K F 0.844 Pathogenic MSH6 P52701 K957G 957 K G 0.36 Neutral MSH6 P52701 K957H 957 K H 0.148 Neutral MSH6 P52701 K957I 957 K I 0.894 Pathogenic MSH6 P52701 K957L 957 K L 0.86 Pathogenic MSH6 P52701 K957M 957 K M 0.654 Pathogenic MSH6 P52701 K957N 957 K N 0.362 Neutral MSH6 P52701 K957P 957 K P 0.694 Pathogenic MSH6 P52701 K957Q 957 K Q 0.026 Neutral MSH6 P52701 K957R 957 K R 0.032 Neutral MSH6 P52701 K957S 957 K S 0.034 Neutral MSH6 P52701 K957T 957 K T 0.03 Neutral MSH6 P52701 K957V 957 K V 0.102 Neutral MSH6 P52701 K957W 957 K W 0.972 Pathogenic MSH6 P52701 K957Y 957 K Y 0.926 Pathogenic MSH6 P52701 Q958A 958 Q A 0.24 Neutral MSH6 P52701 Q958C 958 Q C 0.33 Neutral MSH6 P52701 Q958D 958 Q D 0.676 Pathogenic MSH6 P52701 Q958E 958 Q E 0.642 Pathogenic MSH6 P52701 Q958F 958 Q F 0.856 Pathogenic MSH6 P52701 Q958G 958 Q G 0.472 Neutral MSH6 P52701 Q958H 958 Q H 0.842 Pathogenic MSH6 P52701 Q958I 958 Q I 0.5 Pathogenic MSH6 P52701 Q958K 958 Q K 0.316 Neutral MSH6 P52701 Q958L 958 Q L 0.456 Neutral MSH6 P52701 Q958M 958 Q M 0.352 Neutral MSH6 P52701 Q958N 958 Q N 0.712 Pathogenic MSH6 P52701 Q958P 958 Q P 0.858 Pathogenic MSH6 P52701 Q958R 958 Q R 0.504 Pathogenic MSH6 P52701 Q958S 958 Q S 0.704 Pathogenic MSH6 P52701 Q958T 958 Q T 0.19 Neutral MSH6 P52701 Q958V 958 Q V 0.306 Neutral MSH6 P52701 Q958W 958 Q W 0.782 Pathogenic MSH6 P52701 Q958Y 958 Q Y 0.684 Pathogenic MSH6 P52701 R959A 959 R A 0.136 Neutral MSH6 P52701 R959C 959 R C 0.068 Neutral MSH6 P52701 R959D 959 R D 0.638 Pathogenic MSH6 P52701 R959E 959 R E 0.062 Neutral MSH6 P52701 R959F 959 R F 0.934 Pathogenic MSH6 P52701 R959G 959 R G 0.156 Neutral MSH6 P52701 R959H 959 R H 0.492 Neutral MSH6 P52701 R959I 959 R I 0.902 Pathogenic MSH6 P52701 R959K 959 R K 0.034 Neutral MSH6 P52701 R959L 959 R L 0.884 Pathogenic MSH6 P52701 R959M 959 R M 0.136 Neutral MSH6 P52701 R959N 959 R N 0.418 Neutral MSH6 P52701 R959P 959 R P 0.388 Neutral MSH6 P52701 R959Q 959 R Q 0.016 Neutral MSH6 P52701 R959S 959 R S 0.064 Neutral MSH6 P52701 R959T 959 R T 0.548 Pathogenic MSH6 P52701 R959V 959 R V 0.634 Pathogenic MSH6 P52701 R959W 959 R W 0.91 Pathogenic MSH6 P52701 R959Y 959 R Y 0.892 Pathogenic MSH6 P52701 V96A 96 V A 0.048 Neutral MSH6 P52701 V96C 96 V C 0.104 Neutral MSH6 P52701 V96D 96 V D 0.196 Neutral MSH6 P52701 V96E 96 V E 0.326 Neutral MSH6 P52701 V96F 96 V F 0.372 Neutral MSH6 P52701 V96G 96 V G 0.28 Neutral MSH6 P52701 V96H 96 V H 0.226 Neutral MSH6 P52701 V96I 96 V I 0.146 Neutral MSH6 P52701 V96K 96 V K 0.296 Neutral MSH6 P52701 V96L 96 V L 0.038 Neutral MSH6 P52701 V96M 96 V M 0.168 Neutral MSH6 P52701 V96N 96 V N 0.216 Neutral MSH6 P52701 V96P 96 V P 0.342 Neutral MSH6 P52701 V96Q 96 V Q 0.352 Neutral MSH6 P52701 V96R 96 V R 0.488 Neutral MSH6 P52701 V96S 96 V S 0.142 Neutral MSH6 P52701 V96T 96 V T 0.126 Neutral MSH6 P52701 V96W 96 V W 0.55 Pathogenic MSH6 P52701 V96Y 96 V Y 0.468 Neutral MSH6 P52701 N960A 960 N A 0.084 Neutral MSH6 P52701 N960C 960 N C 0.608 Pathogenic MSH6 P52701 N960D 960 N D 0.296 Neutral MSH6 P52701 N960E 960 N E 0.066 Neutral MSH6 P52701 N960F 960 N F 0.922 Pathogenic MSH6 P52701 N960G 960 N G 0.144 Neutral MSH6 P52701 N960H 960 N H 0.768 Pathogenic MSH6 P52701 N960I 960 N I 0.864 Pathogenic MSH6 P52701 N960K 960 N K 0.234 Neutral MSH6 P52701 N960L 960 N L 0.826 Pathogenic MSH6 P52701 N960M 960 N M 0.862 Pathogenic MSH6 P52701 N960P 960 N P 0.788 Pathogenic MSH6 P52701 N960Q 960 N Q 0.044 Neutral MSH6 P52701 N960R 960 N R 0.454 Neutral MSH6 P52701 N960S 960 N S 0.03 Neutral MSH6 P52701 N960T 960 N T 0.048 Neutral MSH6 P52701 N960V 960 N V 0.934 Pathogenic MSH6 P52701 N960W 960 N W 0.956 Pathogenic MSH6 P52701 N960Y 960 N Y 0.948 Pathogenic MSH6 P52701 R961A 961 R A 0.098 Neutral MSH6 P52701 R961C 961 R C 0.568 Pathogenic MSH6 P52701 R961D 961 R D 0.062 Neutral MSH6 P52701 R961E 961 R E 0.07 Neutral MSH6 P52701 R961F 961 R F 0.09 Neutral MSH6 P52701 R961G 961 R G 0.254 Neutral MSH6 P52701 R961H 961 R H 0.038 Neutral MSH6 P52701 R961I 961 R I 0.258 Neutral MSH6 P52701 R961K 961 R K 0.042 Neutral MSH6 P52701 R961L 961 R L 0.084 Neutral MSH6 P52701 R961M 961 R M 0.596 Pathogenic MSH6 P52701 R961N 961 R N 0.552 Pathogenic MSH6 P52701 R961P 961 R P 0.696 Pathogenic MSH6 P52701 R961Q 961 R Q 0.062 Neutral MSH6 P52701 R961S 961 R S 0.518 Pathogenic MSH6 P52701 R961T 961 R T 0.56 Pathogenic MSH6 P52701 R961V 961 R V 0.648 Pathogenic MSH6 P52701 R961W 961 R W 0.782 Pathogenic MSH6 P52701 R961Y 961 R Y 0.136 Neutral MSH6 P52701 I962A 962 I A 0.206 Neutral MSH6 P52701 I962C 962 I C 0.614 Pathogenic MSH6 P52701 I962D 962 I D 0.764 Pathogenic MSH6 P52701 I962E 962 I E 0.768 Pathogenic MSH6 P52701 I962F 962 I F 0.314 Neutral MSH6 P52701 I962G 962 I G 0.812 Pathogenic MSH6 P52701 I962H 962 I H 0.846 Pathogenic MSH6 P52701 I962K 962 I K 0.856 Pathogenic MSH6 P52701 I962L 962 I L 0.208 Neutral MSH6 P52701 I962M 962 I M 0.408 Neutral MSH6 P52701 I962N 962 I N 0.27 Neutral MSH6 P52701 I962P 962 I P 0.944 Pathogenic MSH6 P52701 I962Q 962 I Q 0.54 Pathogenic MSH6 P52701 I962R 962 I R 0.884 Pathogenic MSH6 P52701 I962S 962 I S 0.63 Pathogenic MSH6 P52701 I962T 962 I T 0.366 Neutral MSH6 P52701 I962V 962 I V 0.37 Neutral MSH6 P52701 I962W 962 I W 0.988 Pathogenic MSH6 P52701 I962Y 962 I Y 0.618 Pathogenic MSH6 P52701 G963A 963 G A 0.35 Neutral MSH6 P52701 G963C 963 G C 0.918 Pathogenic MSH6 P52701 G963D 963 G D 0.704 Pathogenic MSH6 P52701 G963E 963 G E 0.978 Pathogenic MSH6 P52701 G963F 963 G F 0.982 Pathogenic MSH6 P52701 G963H 963 G H 0.702 Pathogenic MSH6 P52701 G963I 963 G I 0.972 Pathogenic MSH6 P52701 G963K 963 G K 0.684 Pathogenic MSH6 P52701 G963L 963 G L 0.982 Pathogenic MSH6 P52701 G963M 963 G M 0.988 Pathogenic MSH6 P52701 G963N 963 G N 0.502 Pathogenic MSH6 P52701 G963P 963 G P 0.968 Pathogenic MSH6 P52701 G963Q 963 G Q 0.718 Pathogenic MSH6 P52701 G963R 963 G R 0.674 Pathogenic MSH6 P52701 G963S 963 G S 0.302 Neutral MSH6 P52701 G963T 963 G T 0.894 Pathogenic MSH6 P52701 G963V 963 G V 0.982 Pathogenic MSH6 P52701 G963W 963 G W 0.972 Pathogenic MSH6 P52701 G963Y 963 G Y 0.972 Pathogenic MSH6 P52701 C964A 964 C A 0.236 Neutral MSH6 P52701 C964D 964 C D 0.056 Neutral MSH6 P52701 C964E 964 C E 0.51 Pathogenic MSH6 P52701 C964F 964 C F 0.714 Pathogenic MSH6 P52701 C964G 964 C G 0.12 Neutral MSH6 P52701 C964H 964 C H 0.668 Pathogenic MSH6 P52701 C964I 964 C I 0.426 Neutral MSH6 P52701 C964K 964 C K 0.62 Pathogenic MSH6 P52701 C964L 964 C L 0.396 Neutral MSH6 P52701 C964M 964 C M 0.566 Pathogenic MSH6 P52701 C964N 964 C N 0.014 Neutral MSH6 P52701 C964P 964 C P 0.858 Pathogenic MSH6 P52701 C964Q 964 C Q 0.386 Neutral MSH6 P52701 C964R 964 C R 0.654 Pathogenic MSH6 P52701 C964S 964 C S 0.022 Neutral MSH6 P52701 C964T 964 C T 0.01 Neutral MSH6 P52701 C964V 964 C V 0.088 Neutral MSH6 P52701 C964W 964 C W 0.934 Pathogenic MSH6 P52701 C964Y 964 C Y 0.88 Pathogenic MSH6 P52701 R965A 965 R A 0.144 Neutral MSH6 P52701 R965C 965 R C 0.646 Pathogenic MSH6 P52701 R965D 965 R D 0.56 Pathogenic MSH6 P52701 R965E 965 R E 0.3 Neutral MSH6 P52701 R965F 965 R F 0.82 Pathogenic MSH6 P52701 R965G 965 R G 0.196 Neutral MSH6 P52701 R965H 965 R H 0.496 Neutral MSH6 P52701 R965I 965 R I 0.886 Pathogenic MSH6 P52701 R965K 965 R K 0.048 Neutral MSH6 P52701 R965L 965 R L 0.856 Pathogenic MSH6 P52701 R965M 965 R M 0.648 Pathogenic MSH6 P52701 R965N 965 R N 0.036 Neutral MSH6 P52701 R965P 965 R P 0.178 Neutral MSH6 P52701 R965Q 965 R Q 0.034 Neutral MSH6 P52701 R965S 965 R S 0.062 Neutral MSH6 P52701 R965T 965 R T 0.07 Neutral MSH6 P52701 R965V 965 R V 0.798 Pathogenic MSH6 P52701 R965W 965 R W 0.888 Pathogenic MSH6 P52701 R965Y 965 R Y 0.858 Pathogenic MSH6 P52701 T966A 966 T A 0.008 Neutral MSH6 P52701 T966C 966 T C 0.17 Neutral MSH6 P52701 T966D 966 T D 0.032 Neutral MSH6 P52701 T966E 966 T E 0.048 Neutral MSH6 P52701 T966F 966 T F 0.5 Pathogenic MSH6 P52701 T966G 966 T G 0.008 Neutral MSH6 P52701 T966H 966 T H 0.214 Neutral MSH6 P52701 T966I 966 T I 0.216 Neutral MSH6 P52701 T966K 966 T K 0.016 Neutral MSH6 P52701 T966L 966 T L 0.142 Neutral MSH6 P52701 T966M 966 T M 0.342 Neutral MSH6 P52701 T966N 966 T N 0.002 Neutral MSH6 P52701 T966P 966 T P 0.294 Neutral MSH6 P52701 T966Q 966 T Q 0.006 Neutral MSH6 P52701 T966R 966 T R 0.392 Neutral MSH6 P52701 T966S 966 T S 0.002 Neutral MSH6 P52701 T966V 966 T V 0.5 Pathogenic MSH6 P52701 T966W 966 T W 0.81 Pathogenic MSH6 P52701 T966Y 966 T Y 0.772 Pathogenic MSH6 P52701 I967A 967 I A 0.128 Neutral MSH6 P52701 I967C 967 I C 0.27 Neutral MSH6 P52701 I967D 967 I D 0.612 Pathogenic MSH6 P52701 I967E 967 I E 0.6 Pathogenic MSH6 P52701 I967F 967 I F 0.672 Pathogenic MSH6 P52701 I967G 967 I G 0.588 Pathogenic MSH6 P52701 I967H 967 I H 0.512 Pathogenic MSH6 P52701 I967K 967 I K 0.598 Pathogenic MSH6 P52701 I967L 967 I L 0.002 Neutral MSH6 P52701 I967M 967 I M 0.036 Neutral MSH6 P52701 I967N 967 I N 0.656 Pathogenic MSH6 P52701 I967P 967 I P 0.716 Pathogenic MSH6 P52701 I967Q 967 I Q 0.636 Pathogenic MSH6 P52701 I967R 967 I R 0.814 Pathogenic MSH6 P52701 I967S 967 I S 0.382 Neutral MSH6 P52701 I967T 967 I T 0.282 Neutral MSH6 P52701 I967V 967 I V 0.002 Neutral MSH6 P52701 I967W 967 I W 0.612 Pathogenic MSH6 P52701 I967Y 967 I Y 0.85 Pathogenic MSH6 P52701 V968A 968 V A 0.002 Neutral MSH6 P52701 V968C 968 V C 0.012 Neutral MSH6 P52701 V968D 968 V D 0.036 Neutral MSH6 P52701 V968E 968 V E 0.066 Neutral MSH6 P52701 V968F 968 V F 0.428 Neutral MSH6 P52701 V968G 968 V G 0.302 Neutral MSH6 P52701 V968H 968 V H 0.216 Neutral MSH6 P52701 V968I 968 V I 0.012 Neutral MSH6 P52701 V968K 968 V K 0.086 Neutral MSH6 P52701 V968L 968 V L 0.006 Neutral MSH6 P52701 V968M 968 V M 0.04 Neutral MSH6 P52701 V968N 968 V N 0.05 Neutral MSH6 P52701 V968P 968 V P 0.372 Neutral MSH6 P52701 V968Q 968 V Q 0.074 Neutral MSH6 P52701 V968R 968 V R 0.44 Neutral MSH6 P52701 V968S 968 V S 0.018 Neutral MSH6 P52701 V968T 968 V T 0.01 Neutral MSH6 P52701 V968W 968 V W 0.604 Pathogenic MSH6 P52701 V968Y 968 V Y 0.53 Pathogenic MSH6 P52701 Y969A 969 Y A 0.206 Neutral MSH6 P52701 Y969C 969 Y C 0.544 Pathogenic MSH6 P52701 Y969D 969 Y D 0.772 Pathogenic MSH6 P52701 Y969E 969 Y E 0.686 Pathogenic MSH6 P52701 Y969F 969 Y F 0.074 Neutral MSH6 P52701 Y969G 969 Y G 0.388 Neutral MSH6 P52701 Y969H 969 Y H 0.454 Neutral MSH6 P52701 Y969I 969 Y I 0.272 Neutral MSH6 P52701 Y969K 969 Y K 0.784 Pathogenic MSH6 P52701 Y969L 969 Y L 0.556 Pathogenic MSH6 P52701 Y969M 969 Y M 0.57 Pathogenic MSH6 P52701 Y969N 969 Y N 0.254 Neutral MSH6 P52701 Y969P 969 Y P 0.694 Pathogenic MSH6 P52701 Y969Q 969 Y Q 0.512 Pathogenic MSH6 P52701 Y969R 969 Y R 0.722 Pathogenic MSH6 P52701 Y969S 969 Y S 0.23 Neutral MSH6 P52701 Y969T 969 Y T 0.194 Neutral MSH6 P52701 Y969V 969 Y V 0.726 Pathogenic MSH6 P52701 Y969W 969 Y W 0.808 Pathogenic MSH6 P52701 W97A 97 W A 0.128 Neutral MSH6 P52701 W97C 97 W C 0.128 Neutral MSH6 P52701 W97D 97 W D 0.19 Neutral MSH6 P52701 W97E 97 W E 0.24 Neutral MSH6 P52701 W97F 97 W F 0.092 Neutral MSH6 P52701 W97G 97 W G 0.138 Neutral MSH6 P52701 W97H 97 W H 0.128 Neutral MSH6 P52701 W97I 97 W I 0.13 Neutral MSH6 P52701 W97K 97 W K 0.234 Neutral MSH6 P52701 W97L 97 W L 0.094 Neutral MSH6 P52701 W97M 97 W M 0.122 Neutral MSH6 P52701 W97N 97 W N 0.138 Neutral MSH6 P52701 W97P 97 W P 0.146 Neutral MSH6 P52701 W97Q 97 W Q 0.138 Neutral MSH6 P52701 W97R 97 W R 0.228 Neutral MSH6 P52701 W97S 97 W S 0.144 Neutral MSH6 P52701 W97T 97 W T 0.128 Neutral MSH6 P52701 W97V 97 W V 0.15 Neutral MSH6 P52701 W97Y 97 W Y 0.194 Neutral MSH6 P52701 W970A 970 W A 0.172 Neutral MSH6 P52701 W970C 970 W C 0.31 Neutral MSH6 P52701 W970D 970 W D 0.398 Neutral MSH6 P52701 W970E 970 W E 0.534 Pathogenic MSH6 P52701 W970F 970 W F 0.024 Neutral MSH6 P52701 W970G 970 W G 0.296 Neutral MSH6 P52701 W970H 970 W H 0.068 Neutral MSH6 P52701 W970I 970 W I 0.204 Neutral MSH6 P52701 W970K 970 W K 0.104 Neutral MSH6 P52701 W970L 970 W L 0.226 Neutral MSH6 P52701 W970M 970 W M 0.286 Neutral MSH6 P52701 W970N 970 W N 0.344 Neutral MSH6 P52701 W970P 970 W P 0.388 Neutral MSH6 P52701 W970Q 970 W Q 0.316 Neutral MSH6 P52701 W970R 970 W R 0.074 Neutral MSH6 P52701 W970S 970 W S 0.28 Neutral MSH6 P52701 W970T 970 W T 0.12 Neutral MSH6 P52701 W970V 970 W V 0.024 Neutral MSH6 P52701 W970Y 970 W Y 0.024 Neutral MSH6 P52701 G971A 971 G A 0.448 Neutral MSH6 P52701 G971C 971 G C 0.808 Pathogenic MSH6 P52701 G971D 971 G D 0.466 Neutral MSH6 P52701 G971E 971 G E 0.956 Pathogenic MSH6 P52701 G971F 971 G F 0.938 Pathogenic MSH6 P52701 G971H 971 G H 0.636 Pathogenic MSH6 P52701 G971I 971 G I 0.934 Pathogenic MSH6 P52701 G971K 971 G K 0.972 Pathogenic MSH6 P52701 G971L 971 G L 0.93 Pathogenic MSH6 P52701 G971M 971 G M 0.912 Pathogenic MSH6 P52701 G971N 971 G N 0.488 Neutral MSH6 P52701 G971P 971 G P 0.932 Pathogenic MSH6 P52701 G971Q 971 G Q 0.866 Pathogenic MSH6 P52701 G971R 971 G R 0.986 Pathogenic MSH6 P52701 G971S 971 G S 0.102 Neutral MSH6 P52701 G971T 971 G T 0.564 Pathogenic MSH6 P52701 G971V 971 G V 0.974 Pathogenic MSH6 P52701 G971W 971 G W 0.936 Pathogenic MSH6 P52701 G971Y 971 G Y 0.95 Pathogenic MSH6 P52701 I972A 972 I A 0.018 Neutral MSH6 P52701 I972C 972 I C 0.146 Neutral MSH6 P52701 I972D 972 I D 0.224 Neutral MSH6 P52701 I972E 972 I E 0.214 Neutral MSH6 P52701 I972F 972 I F 0.348 Neutral MSH6 P52701 I972G 972 I G 0.122 Neutral MSH6 P52701 I972H 972 I H 0.152 Neutral MSH6 P52701 I972K 972 I K 0.228 Neutral MSH6 P52701 I972L 972 I L 0.208 Neutral MSH6 P52701 I972M 972 I M 0.172 Neutral MSH6 P52701 I972N 972 I N 0.114 Neutral MSH6 P52701 I972P 972 I P 0.2 Neutral MSH6 P52701 I972Q 972 I Q 0.282 Neutral MSH6 P52701 I972R 972 I R 0.446 Neutral MSH6 P52701 I972S 972 I S 0.084 Neutral MSH6 P52701 I972T 972 I T 0.014 Neutral MSH6 P52701 I972V 972 I V 0.098 Neutral MSH6 P52701 I972W 972 I W 0.544 Pathogenic MSH6 P52701 I972Y 972 I Y 0.502 Pathogenic MSH6 P52701 G973A 973 G A 0.32 Neutral MSH6 P52701 G973C 973 G C 0.934 Pathogenic MSH6 P52701 G973D 973 G D 0.526 Pathogenic MSH6 P52701 G973E 973 G E 0.684 Pathogenic MSH6 P52701 G973F 973 G F 0.988 Pathogenic MSH6 P52701 G973H 973 G H 0.992 Pathogenic MSH6 P52701 G973I 973 G I 0.978 Pathogenic MSH6 P52701 G973K 973 G K 0.702 Pathogenic MSH6 P52701 G973L 973 G L 0.988 Pathogenic MSH6 P52701 G973M 973 G M 0.994 Pathogenic MSH6 P52701 G973N 973 G N 0.576 Pathogenic MSH6 P52701 G973P 973 G P 0.982 Pathogenic MSH6 P52701 G973Q 973 G Q 0.978 Pathogenic MSH6 P52701 G973R 973 G R 0.748 Pathogenic MSH6 P52701 G973S 973 G S 0.344 Neutral MSH6 P52701 G973T 973 G T 0.92 Pathogenic MSH6 P52701 G973V 973 G V 0.99 Pathogenic MSH6 P52701 G973W 973 G W 0.984 Pathogenic MSH6 P52701 G973Y 973 G Y 0.984 Pathogenic MSH6 P52701 R974A 974 R A 0.542 Pathogenic MSH6 P52701 R974C 974 R C 0.932 Pathogenic MSH6 P52701 R974D 974 R D 0.192 Neutral MSH6 P52701 R974E 974 R E 0.184 Neutral MSH6 P52701 R974F 974 R F 0.948 Pathogenic MSH6 P52701 R974G 974 R G 0.406 Neutral MSH6 P52701 R974H 974 R H 0.532 Pathogenic MSH6 P52701 R974I 974 R I 0.96 Pathogenic MSH6 P52701 R974K 974 R K 0.548 Pathogenic MSH6 P52701 R974L 974 R L 0.968 Pathogenic MSH6 P52701 R974M 974 R M 0.782 Pathogenic MSH6 P52701 R974N 974 R N 0.138 Neutral MSH6 P52701 R974P 974 R P 0.968 Pathogenic MSH6 P52701 R974Q 974 R Q 0.58 Pathogenic MSH6 P52701 R974S 974 R S 0.868 Pathogenic MSH6 P52701 R974T 974 R T 0.904 Pathogenic MSH6 P52701 R974V 974 R V 0.958 Pathogenic MSH6 P52701 R974W 974 R W 0.954 Pathogenic MSH6 P52701 R974Y 974 R Y 0.95 Pathogenic MSH6 P52701 N975A 975 N A 0.53 Pathogenic MSH6 P52701 N975C 975 N C 0.6 Pathogenic MSH6 P52701 N975D 975 N D 0.016 Neutral MSH6 P52701 N975E 975 N E 0.042 Neutral MSH6 P52701 N975F 975 N F 0.916 Pathogenic MSH6 P52701 N975G 975 N G 0.62 Pathogenic MSH6 P52701 N975H 975 N H 0.764 Pathogenic MSH6 P52701 N975I 975 N I 0.894 Pathogenic MSH6 P52701 N975K 975 N K 0.07 Neutral MSH6 P52701 N975L 975 N L 0.802 Pathogenic MSH6 P52701 N975M 975 N M 0.858 Pathogenic MSH6 P52701 N975P 975 N P 0.766 Pathogenic MSH6 P52701 N975Q 975 N Q 0.652 Pathogenic MSH6 P52701 N975R 975 N R 0.756 Pathogenic MSH6 P52701 N975S 975 N S 0.042 Neutral MSH6 P52701 N975T 975 N T 0.1 Neutral MSH6 P52701 N975V 975 N V 0.136 Neutral MSH6 P52701 N975W 975 N W 0.948 Pathogenic MSH6 P52701 N975Y 975 N Y 0.936 Pathogenic MSH6 P52701 R976A 976 R A 0.138 Neutral MSH6 P52701 R976C 976 R C 0.47 Neutral MSH6 P52701 R976D 976 R D 0.616 Pathogenic MSH6 P52701 R976E 976 R E 0.07 Neutral MSH6 P52701 R976F 976 R F 0.936 Pathogenic MSH6 P52701 R976G 976 R G 0.21 Neutral MSH6 P52701 R976H 976 R H 0.166 Neutral MSH6 P52701 R976I 976 R I 0.178 Neutral MSH6 P52701 R976K 976 R K 0.046 Neutral MSH6 P52701 R976L 976 R L 0.362 Neutral MSH6 P52701 R976M 976 R M 0.546 Pathogenic MSH6 P52701 R976N 976 R N 0.486 Neutral MSH6 P52701 R976P 976 R P 0.676 Pathogenic MSH6 P52701 R976Q 976 R Q 0.422 Neutral MSH6 P52701 R976S 976 R S 0.312 Neutral MSH6 P52701 R976T 976 R T 0.062 Neutral MSH6 P52701 R976V 976 R V 0.124 Neutral MSH6 P52701 R976W 976 R W 0.914 Pathogenic MSH6 P52701 R976Y 976 R Y 0.892 Pathogenic MSH6 P52701 Y977A 977 Y A 0.426 Neutral MSH6 P52701 Y977C 977 Y C 0.36 Neutral MSH6 P52701 Y977D 977 Y D 0.814 Pathogenic MSH6 P52701 Y977E 977 Y E 0.716 Pathogenic MSH6 P52701 Y977F 977 Y F 0.152 Neutral MSH6 P52701 Y977G 977 Y G 0.474 Neutral MSH6 P52701 Y977H 977 Y H 0.272 Neutral MSH6 P52701 Y977I 977 Y I 0.806 Pathogenic MSH6 P52701 Y977K 977 Y K 0.818 Pathogenic MSH6 P52701 Y977L 977 Y L 0.708 Pathogenic MSH6 P52701 Y977M 977 Y M 0.164 Neutral MSH6 P52701 Y977N 977 Y N 0.71 Pathogenic MSH6 P52701 Y977P 977 Y P 0.798 Pathogenic MSH6 P52701 Y977Q 977 Y Q 0.618 Pathogenic MSH6 P52701 Y977R 977 Y R 0.734 Pathogenic MSH6 P52701 Y977S 977 Y S 0.474 Neutral MSH6 P52701 Y977T 977 Y T 0.658 Pathogenic MSH6 P52701 Y977V 977 Y V 0.712 Pathogenic MSH6 P52701 Y977W 977 Y W 0.91 Pathogenic MSH6 P52701 Q978A 978 Q A 0.78 Pathogenic MSH6 P52701 Q978C 978 Q C 0.422 Neutral MSH6 P52701 Q978D 978 Q D 0.858 Pathogenic MSH6 P52701 Q978E 978 Q E 0.572 Pathogenic MSH6 P52701 Q978F 978 Q F 0.93 Pathogenic MSH6 P52701 Q978G 978 Q G 0.57 Pathogenic MSH6 P52701 Q978H 978 Q H 0.988 Pathogenic MSH6 P52701 Q978I 978 Q I 0.95 Pathogenic MSH6 P52701 Q978K 978 Q K 0.972 Pathogenic MSH6 P52701 Q978L 978 Q L 0.388 Neutral MSH6 P52701 Q978M 978 Q M 0.69 Pathogenic MSH6 P52701 Q978N 978 Q N 0.89 Pathogenic MSH6 P52701 Q978P 978 Q P 0.692 Pathogenic MSH6 P52701 Q978R 978 Q R 0.924 Pathogenic MSH6 P52701 Q978S 978 Q S 0.836 Pathogenic MSH6 P52701 Q978T 978 Q T 0.254 Neutral MSH6 P52701 Q978V 978 Q V 0.65 Pathogenic MSH6 P52701 Q978W 978 Q W 0.962 Pathogenic MSH6 P52701 Q978Y 978 Q Y 0.95 Pathogenic MSH6 P52701 L979A 979 L A 0.564 Pathogenic MSH6 P52701 L979C 979 L C 0.684 Pathogenic MSH6 P52701 L979D 979 L D 0.9 Pathogenic MSH6 P52701 L979E 979 L E 0.88 Pathogenic MSH6 P52701 L979F 979 L F 0.966 Pathogenic MSH6 P52701 L979G 979 L G 0.802 Pathogenic MSH6 P52701 L979H 979 L H 0.8 Pathogenic MSH6 P52701 L979I 979 L I 0.136 Neutral MSH6 P52701 L979K 979 L K 0.744 Pathogenic MSH6 P52701 L979M 979 L M 0.162 Neutral MSH6 P52701 L979N 979 L N 0.77 Pathogenic MSH6 P52701 L979P 979 L P 0.996 Pathogenic MSH6 P52701 L979Q 979 L Q 0.616 Pathogenic MSH6 P52701 L979R 979 L R 0.996 Pathogenic MSH6 P52701 L979S 979 L S 0.61 Pathogenic MSH6 P52701 L979T 979 L T 0.588 Pathogenic MSH6 P52701 L979V 979 L V 0.086 Neutral MSH6 P52701 L979W 979 L W 0.934 Pathogenic MSH6 P52701 L979Y 979 L Y 0.894 Pathogenic MSH6 P52701 A98C 98 A C 0.32 Neutral MSH6 P52701 A98D 98 A D 0.452 Neutral MSH6 P52701 A98E 98 A E 0.494 Neutral MSH6 P52701 A98F 98 A F 0.716 Pathogenic MSH6 P52701 A98G 98 A G 0.184 Neutral MSH6 P52701 A98H 98 A H 0.498 Neutral MSH6 P52701 A98I 98 A I 0.66 Pathogenic MSH6 P52701 A98K 98 A K 0.582 Pathogenic MSH6 P52701 A98L 98 A L 0.644 Pathogenic MSH6 P52701 A98M 98 A M 0.478 Neutral MSH6 P52701 A98N 98 A N 0.454 Neutral MSH6 P52701 A98P 98 A P 0.454 Neutral MSH6 P52701 A98Q 98 A Q 0.482 Neutral MSH6 P52701 A98R 98 A R 0.576 Pathogenic MSH6 P52701 A98S 98 A S 0.082 Neutral MSH6 P52701 A98T 98 A T 0.278 Neutral MSH6 P52701 A98V 98 A V 0.37 Neutral MSH6 P52701 A98W 98 A W 0.748 Pathogenic MSH6 P52701 A98Y 98 A Y 0.752 Pathogenic MSH6 P52701 E980A 980 E A 0.808 Pathogenic MSH6 P52701 E980C 980 E C 0.758 Pathogenic MSH6 P52701 E980D 980 E D 0.41 Neutral MSH6 P52701 E980F 980 E F 0.962 Pathogenic MSH6 P52701 E980G 980 E G 0.342 Neutral MSH6 P52701 E980H 980 E H 0.726 Pathogenic MSH6 P52701 E980I 980 E I 0.98 Pathogenic MSH6 P52701 E980K 980 E K 0.902 Pathogenic MSH6 P52701 E980L 980 E L 0.972 Pathogenic MSH6 P52701 E980M 980 E M 0.904 Pathogenic MSH6 P52701 E980N 980 E N 0.778 Pathogenic MSH6 P52701 E980P 980 E P 0.938 Pathogenic MSH6 P52701 E980Q 980 E Q 0.38 Neutral MSH6 P52701 E980R 980 E R 0.932 Pathogenic MSH6 P52701 E980S 980 E S 0.894 Pathogenic MSH6 P52701 E980T 980 E T 0.848 Pathogenic MSH6 P52701 E980V 980 E V 0.92 Pathogenic MSH6 P52701 E980W 980 E W 0.98 Pathogenic MSH6 P52701 E980Y 980 E Y 0.96 Pathogenic MSH6 P52701 I981A 981 I A 0.106 Neutral MSH6 P52701 I981C 981 I C 0.63 Pathogenic MSH6 P52701 I981D 981 I D 0.772 Pathogenic MSH6 P52701 I981E 981 I E 0.774 Pathogenic MSH6 P52701 I981F 981 I F 0.426 Neutral MSH6 P52701 I981G 981 I G 0.814 Pathogenic MSH6 P52701 I981H 981 I H 0.85 Pathogenic MSH6 P52701 I981K 981 I K 0.862 Pathogenic MSH6 P52701 I981L 981 I L 0.108 Neutral MSH6 P52701 I981M 981 I M 0.168 Neutral MSH6 P52701 I981N 981 I N 0.798 Pathogenic MSH6 P52701 I981P 981 I P 0.94 Pathogenic MSH6 P52701 I981Q 981 I Q 0.806 Pathogenic MSH6 P52701 I981R 981 I R 0.884 Pathogenic MSH6 P52701 I981S 981 I S 0.63 Pathogenic MSH6 P52701 I981T 981 I T 0.162 Neutral MSH6 P52701 I981V 981 I V 0.248 Neutral MSH6 P52701 I981W 981 I W 0.976 Pathogenic MSH6 P52701 I981Y 981 I Y 0.97 Pathogenic MSH6 P52701 P982A 982 P A 0.45 Neutral MSH6 P52701 P982C 982 P C 0.92 Pathogenic MSH6 P52701 P982D 982 P D 0.87 Pathogenic MSH6 P52701 P982E 982 P E 0.962 Pathogenic MSH6 P52701 P982F 982 P F 1 Pathogenic MSH6 P52701 P982G 982 P G 0.698 Pathogenic MSH6 P52701 P982H 982 P H 0.98 Pathogenic MSH6 P52701 P982I 982 P I 0.932 Pathogenic MSH6 P52701 P982K 982 P K 0.952 Pathogenic MSH6 P52701 P982L 982 P L 0.998 Pathogenic MSH6 P52701 P982M 982 P M 0.962 Pathogenic MSH6 P52701 P982N 982 P N 0.79 Pathogenic MSH6 P52701 P982Q 982 P Q 0.884 Pathogenic MSH6 P52701 P982R 982 P R 0.766 Pathogenic MSH6 P52701 P982S 982 P S 0.268 Neutral MSH6 P52701 P982T 982 P T 0.746 Pathogenic MSH6 P52701 P982V 982 P V 0.846 Pathogenic MSH6 P52701 P982W 982 P W 0.934 Pathogenic MSH6 P52701 P982Y 982 P Y 0.928 Pathogenic MSH6 P52701 E983A 983 E A 0.382 Neutral MSH6 P52701 E983C 983 E C 0.436 Neutral MSH6 P52701 E983D 983 E D 0.028 Neutral MSH6 P52701 E983F 983 E F 0.796 Pathogenic MSH6 P52701 E983G 983 E G 0.15 Neutral MSH6 P52701 E983H 983 E H 0.554 Pathogenic MSH6 P52701 E983I 983 E I 0.868 Pathogenic MSH6 P52701 E983K 983 E K 0.676 Pathogenic MSH6 P52701 E983L 983 E L 0.846 Pathogenic MSH6 P52701 E983M 983 E M 0.656 Pathogenic MSH6 P52701 E983N 983 E N 0.186 Neutral MSH6 P52701 E983P 983 E P 0.848 Pathogenic MSH6 P52701 E983Q 983 E Q 0.17 Neutral MSH6 P52701 E983R 983 E R 0.412 Neutral MSH6 P52701 E983S 983 E S 0.484 Neutral MSH6 P52701 E983T 983 E T 0.566 Pathogenic MSH6 P52701 E983V 983 E V 0.808 Pathogenic MSH6 P52701 E983W 983 E W 0.94 Pathogenic MSH6 P52701 E983Y 983 E Y 0.862 Pathogenic MSH6 P52701 N984A 984 N A 0.01 Neutral MSH6 P52701 N984C 984 N C 0.232 Neutral MSH6 P52701 N984D 984 N D 0.036 Neutral MSH6 P52701 N984E 984 N E 0.052 Neutral MSH6 P52701 N984F 984 N F 0.58 Pathogenic MSH6 P52701 N984G 984 N G 0.028 Neutral MSH6 P52701 N984H 984 N H 0.176 Neutral MSH6 P52701 N984I 984 N I 0.432 Neutral MSH6 P52701 N984K 984 N K 0.418 Neutral MSH6 P52701 N984L 984 N L 0.434 Neutral MSH6 P52701 N984M 984 N M 0.362 Neutral MSH6 P52701 N984P 984 N P 0.392 Neutral MSH6 P52701 N984Q 984 N Q 0.174 Neutral MSH6 P52701 N984R 984 N R 0.316 Neutral MSH6 P52701 N984S 984 N S 0.006 Neutral MSH6 P52701 N984T 984 N T 0.008 Neutral MSH6 P52701 N984V 984 N V 0.426 Neutral MSH6 P52701 N984W 984 N W 0.712 Pathogenic MSH6 P52701 N984Y 984 N Y 0.666 Pathogenic MSH6 P52701 F985A 985 F A 0.046 Neutral MSH6 P52701 F985C 985 F C 0.088 Neutral MSH6 P52701 F985D 985 F D 0.166 Neutral MSH6 P52701 F985E 985 F E 0.2 Neutral MSH6 P52701 F985G 985 F G 0.148 Neutral MSH6 P52701 F985H 985 F H 0.002 Neutral MSH6 P52701 F985I 985 F I 0.002 Neutral MSH6 P52701 F985K 985 F K 0.194 Neutral MSH6 P52701 F985L 985 F L 0.06 Neutral MSH6 P52701 F985M 985 F M 0.068 Neutral MSH6 P52701 F985N 985 F N 0.184 Neutral MSH6 P52701 F985P 985 F P 0.188 Neutral MSH6 P52701 F985Q 985 F Q 0.18 Neutral MSH6 P52701 F985R 985 F R 0.16 Neutral MSH6 P52701 F985S 985 F S 0.158 Neutral MSH6 P52701 F985T 985 F T 0.172 Neutral MSH6 P52701 F985V 985 F V 0.01 Neutral MSH6 P52701 F985W 985 F W 0.3 Neutral MSH6 P52701 F985Y 985 F Y 0.158 Neutral MSH6 P52701 T986A 986 T A 0.002 Neutral MSH6 P52701 T986C 986 T C 0.034 Neutral MSH6 P52701 T986D 986 T D 0.058 Neutral MSH6 P52701 T986E 986 T E 0.064 Neutral MSH6 P52701 T986F 986 T F 0.23 Neutral MSH6 P52701 T986G 986 T G 0.058 Neutral MSH6 P52701 T986H 986 T H 0.096 Neutral MSH6 P52701 T986I 986 T I 0.044 Neutral MSH6 P52701 T986K 986 T K 0.028 Neutral MSH6 P52701 T986L 986 T L 0.008 Neutral MSH6 P52701 T986M 986 T M 0.106 Neutral MSH6 P52701 T986N 986 T N 0.02 Neutral MSH6 P52701 T986P 986 T P 0.084 Neutral MSH6 P52701 T986Q 986 T Q 0 Neutral MSH6 P52701 T986R 986 T R 0.148 Neutral MSH6 P52701 T986S 986 T S 0 Neutral MSH6 P52701 T986V 986 T V 0.016 Neutral MSH6 P52701 T986W 986 T W 0.498 Neutral MSH6 P52701 T986Y 986 T Y 0.454 Neutral MSH6 P52701 T987A 987 T A 0.002 Neutral MSH6 P52701 T987C 987 T C 0.004 Neutral MSH6 P52701 T987D 987 T D 0.02 Neutral MSH6 P52701 T987E 987 T E 0.024 Neutral MSH6 P52701 T987F 987 T F 0.214 Neutral MSH6 P52701 T987G 987 T G 0.036 Neutral MSH6 P52701 T987H 987 T H 0.034 Neutral MSH6 P52701 T987I 987 T I 0.076 Neutral MSH6 P52701 T987K 987 T K 0.026 Neutral MSH6 P52701 T987L 987 T L 0.008 Neutral MSH6 P52701 T987M 987 T M 0.032 Neutral MSH6 P52701 T987N 987 T N 0.012 Neutral MSH6 P52701 T987P 987 T P 0.02 Neutral MSH6 P52701 T987Q 987 T Q 0.016 Neutral MSH6 P52701 T987R 987 T R 0.26 Neutral MSH6 P52701 T987S 987 T S 0 Neutral MSH6 P52701 T987V 987 T V 0.02 Neutral MSH6 P52701 T987W 987 T W 0.466 Neutral MSH6 P52701 T987Y 987 T Y 0.424 Neutral MSH6 P52701 R988A 988 R A 0.15 Neutral MSH6 P52701 R988C 988 R C 0.242 Neutral MSH6 P52701 R988D 988 R D 0.262 Neutral MSH6 P52701 R988E 988 R E 0.264 Neutral MSH6 P52701 R988F 988 R F 0.458 Neutral MSH6 P52701 R988G 988 R G 0.094 Neutral MSH6 P52701 R988H 988 R H 0.01 Neutral MSH6 P52701 R988I 988 R I 0.496 Neutral MSH6 P52701 R988K 988 R K 0.006 Neutral MSH6 P52701 R988L 988 R L 0.45 Neutral MSH6 P52701 R988M 988 R M 0.256 Neutral MSH6 P52701 R988N 988 R N 0.256 Neutral MSH6 P52701 R988P 988 R P 0.428 Neutral MSH6 P52701 R988Q 988 R Q 0.236 Neutral MSH6 P52701 R988S 988 R S 0.2 Neutral MSH6 P52701 R988T 988 R T 0.212 Neutral MSH6 P52701 R988V 988 R V 0.06 Neutral MSH6 P52701 R988W 988 R W 0.618 Pathogenic MSH6 P52701 R988Y 988 R Y 0.462 Neutral MSH6 P52701 N989A 989 N A 0.012 Neutral MSH6 P52701 N989C 989 N C 0.246 Neutral MSH6 P52701 N989D 989 N D 0.012 Neutral MSH6 P52701 N989E 989 N E 0.012 Neutral MSH6 P52701 N989F 989 N F 0.474 Neutral MSH6 P52701 N989G 989 N G 0.238 Neutral MSH6 P52701 N989H 989 N H 0.028 Neutral MSH6 P52701 N989I 989 N I 0.266 Neutral MSH6 P52701 N989K 989 N K 0.05 Neutral MSH6 P52701 N989L 989 N L 0.116 Neutral MSH6 P52701 N989M 989 N M 0.424 Neutral MSH6 P52701 N989P 989 N P 0.418 Neutral MSH6 P52701 N989Q 989 N Q 0.148 Neutral MSH6 P52701 N989R 989 N R 0.388 Neutral MSH6 P52701 N989S 989 N S 0.006 Neutral MSH6 P52701 N989T 989 N T 0.138 Neutral MSH6 P52701 N989V 989 N V 0.05 Neutral MSH6 P52701 N989W 989 N W 0.766 Pathogenic MSH6 P52701 N989Y 989 N Y 0.598 Pathogenic MSH6 P52701 K99A 99 K A 0.086 Neutral MSH6 P52701 K99C 99 K C 0.058 Neutral MSH6 P52701 K99D 99 K D 0.1 Neutral MSH6 P52701 K99E 99 K E 0.11 Neutral MSH6 P52701 K99F 99 K F 0.364 Neutral MSH6 P52701 K99G 99 K G 0.182 Neutral MSH6 P52701 K99H 99 K H 0.084 Neutral MSH6 P52701 K99I 99 K I 0.396 Neutral MSH6 P52701 K99L 99 K L 0.38 Neutral MSH6 P52701 K99M 99 K M 0.19 Neutral MSH6 P52701 K99N 99 K N 0.122 Neutral MSH6 P52701 K99P 99 K P 0.388 Neutral MSH6 P52701 K99Q 99 K Q 0.018 Neutral MSH6 P52701 K99R 99 K R 0.06 Neutral MSH6 P52701 K99S 99 K S 0.24 Neutral MSH6 P52701 K99T 99 K T 0.146 Neutral MSH6 P52701 K99V 99 K V 0.298 Neutral MSH6 P52701 K99W 99 K W 0.678 Pathogenic MSH6 P52701 K99Y 99 K Y 0.582 Pathogenic MSH6 P52701 L990A 990 L A 0.012 Neutral MSH6 P52701 L990C 990 L C 0.024 Neutral MSH6 P52701 L990D 990 L D 0.05 Neutral MSH6 P52701 L990E 990 L E 0.04 Neutral MSH6 P52701 L990F 990 L F 0.448 Neutral MSH6 P52701 L990G 990 L G 0.098 Neutral MSH6 P52701 L990H 990 L H 0.05 Neutral MSH6 P52701 L990I 990 L I 0.002 Neutral MSH6 P52701 L990K 990 L K 0.022 Neutral MSH6 P52701 L990M 990 L M 0.19 Neutral MSH6 P52701 L990N 990 L N 0.042 Neutral MSH6 P52701 L990P 990 L P 0.344 Neutral MSH6 P52701 L990Q 990 L Q 0.11 Neutral MSH6 P52701 L990R 990 L R 0.378 Neutral MSH6 P52701 L990S 990 L S 0.016 Neutral MSH6 P52701 L990T 990 L T 0.018 Neutral MSH6 P52701 L990V 990 L V 0 Neutral MSH6 P52701 L990W 990 L W 0.572 Pathogenic MSH6 P52701 L990Y 990 L Y 0.57 Pathogenic MSH6 P52701 P991A 991 P A 0.114 Neutral MSH6 P52701 P991C 991 P C 0.286 Neutral MSH6 P52701 P991D 991 P D 0.19 Neutral MSH6 P52701 P991E 991 P E 0.616 Pathogenic MSH6 P52701 P991F 991 P F 0.796 Pathogenic MSH6 P52701 P991G 991 P G 0.068 Neutral MSH6 P52701 P991H 991 P H 0.748 Pathogenic MSH6 P52701 P991I 991 P I 0.096 Neutral MSH6 P52701 P991K 991 P K 0.316 Neutral MSH6 P52701 P991L 991 P L 0.096 Neutral MSH6 P52701 P991M 991 P M 0.248 Neutral MSH6 P52701 P991N 991 P N 0.052 Neutral MSH6 P52701 P991Q 991 P Q 0.602 Pathogenic MSH6 P52701 P991R 991 P R 0.724 Pathogenic MSH6 P52701 P991S 991 P S 0.064 Neutral MSH6 P52701 P991T 991 P T 0.072 Neutral MSH6 P52701 P991V 991 P V 0.092 Neutral MSH6 P52701 P991W 991 P W 0.812 Pathogenic MSH6 P52701 P991Y 991 P Y 0.802 Pathogenic MSH6 P52701 E992A 992 E A 0.076 Neutral MSH6 P52701 E992C 992 E C 0.022 Neutral MSH6 P52701 E992D 992 E D 0.002 Neutral MSH6 P52701 E992F 992 E F 0.422 Neutral MSH6 P52701 E992G 992 E G 0.004 Neutral MSH6 P52701 E992H 992 E H 0.02 Neutral MSH6 P52701 E992I 992 E I 0.49 Neutral MSH6 P52701 E992K 992 E K 0.004 Neutral MSH6 P52701 E992L 992 E L 0.446 Neutral MSH6 P52701 E992M 992 E M 0.278 Neutral MSH6 P52701 E992N 992 E N 0.002 Neutral MSH6 P52701 E992P 992 E P 0.072 Neutral MSH6 P52701 E992Q 992 E Q 0 Neutral MSH6 P52701 E992R 992 E R 0.02 Neutral MSH6 P52701 E992S 992 E S 0.016 Neutral MSH6 P52701 E992T 992 E T 0.248 Neutral MSH6 P52701 E992V 992 E V 0.374 Neutral MSH6 P52701 E992W 992 E W 0.694 Pathogenic MSH6 P52701 E992Y 992 E Y 0.58 Pathogenic MSH6 P52701 E993A 993 E A 0.236 Neutral MSH6 P52701 E993C 993 E C 0.448 Neutral MSH6 P52701 E993D 993 E D 0.022 Neutral MSH6 P52701 E993F 993 E F 0.848 Pathogenic MSH6 P52701 E993G 993 E G 0.028 Neutral MSH6 P52701 E993H 993 E H 0.35 Neutral MSH6 P52701 E993I 993 E I 0.91 Pathogenic MSH6 P52701 E993K 993 E K 0.17 Neutral MSH6 P52701 E993L 993 E L 0.886 Pathogenic MSH6 P52701 E993M 993 E M 0.69 Pathogenic MSH6 P52701 E993N 993 E N 0.014 Neutral MSH6 P52701 E993P 993 E P 0.87 Pathogenic MSH6 P52701 E993Q 993 E Q 0.138 Neutral MSH6 P52701 E993R 993 E R 0.53 Pathogenic MSH6 P52701 E993S 993 E S 0.044 Neutral MSH6 P52701 E993T 993 E T 0.058 Neutral MSH6 P52701 E993V 993 E V 0.826 Pathogenic MSH6 P52701 E993W 993 E W 0.968 Pathogenic MSH6 P52701 E993Y 993 E Y 0.896 Pathogenic MSH6 P52701 Y994A 994 Y A 0.33 Neutral MSH6 P52701 Y994C 994 Y C 0.538 Pathogenic MSH6 P52701 Y994D 994 Y D 0.788 Pathogenic MSH6 P52701 Y994E 994 Y E 0.706 Pathogenic MSH6 P52701 Y994F 994 Y F 0.058 Neutral MSH6 P52701 Y994G 994 Y G 0.378 Neutral MSH6 P52701 Y994H 994 Y H 0.092 Neutral MSH6 P52701 Y994I 994 Y I 0.674 Pathogenic MSH6 P52701 Y994K 994 Y K 0.802 Pathogenic MSH6 P52701 Y994L 994 Y L 0.19 Neutral MSH6 P52701 Y994M 994 Y M 0.58 Pathogenic MSH6 P52701 Y994N 994 Y N 0.612 Pathogenic MSH6 P52701 Y994P 994 Y P 0.7 Pathogenic MSH6 P52701 Y994Q 994 Y Q 0.524 Pathogenic MSH6 P52701 Y994R 994 Y R 0.738 Pathogenic MSH6 P52701 Y994S 994 Y S 0.374 Neutral MSH6 P52701 Y994T 994 Y T 0.532 Pathogenic MSH6 P52701 Y994V 994 Y V 0.74 Pathogenic MSH6 P52701 Y994W 994 Y W 0.158 Neutral MSH6 P52701 E995A 995 E A 0.24 Neutral MSH6 P52701 E995C 995 E C 0.114 Neutral MSH6 P52701 E995D 995 E D 0.018 Neutral MSH6 P52701 E995F 995 E F 0.882 Pathogenic MSH6 P52701 E995G 995 E G 0.052 Neutral MSH6 P52701 E995H 995 E H 0.344 Neutral MSH6 P52701 E995I 995 E I 0.22 Neutral MSH6 P52701 E995K 995 E K 0.166 Neutral MSH6 P52701 E995L 995 E L 0.816 Pathogenic MSH6 P52701 E995M 995 E M 0.726 Pathogenic MSH6 P52701 E995N 995 E N 0.11 Neutral MSH6 P52701 E995P 995 E P 0.89 Pathogenic MSH6 P52701 E995Q 995 E Q 0.022 Neutral MSH6 P52701 E995R 995 E R 0.12 Neutral MSH6 P52701 E995S 995 E S 0.05 Neutral MSH6 P52701 E995T 995 E T 0.062 Neutral MSH6 P52701 E995V 995 E V 0.094 Neutral MSH6 P52701 E995W 995 E W 0.97 Pathogenic MSH6 P52701 E995Y 995 E Y 0.92 Pathogenic MSH6 P52701 L996A 996 L A 0.108 Neutral MSH6 P52701 L996C 996 L C 0.642 Pathogenic MSH6 P52701 L996D 996 L D 0.894 Pathogenic MSH6 P52701 L996E 996 L E 0.858 Pathogenic MSH6 P52701 L996F 996 L F 0.438 Neutral MSH6 P52701 L996G 996 L G 0.804 Pathogenic MSH6 P52701 L996H 996 L H 0.71 Pathogenic MSH6 P52701 L996I 996 L I 0.146 Neutral MSH6 P52701 L996K 996 L K 0.126 Neutral MSH6 P52701 L996M 996 L M 0.23 Neutral MSH6 P52701 L996N 996 L N 0.778 Pathogenic MSH6 P52701 L996P 996 L P 0.676 Pathogenic MSH6 P52701 L996Q 996 L Q 0.126 Neutral MSH6 P52701 L996R 996 L R 0.718 Pathogenic MSH6 P52701 L996S 996 L S 0.358 Neutral MSH6 P52701 L996T 996 L T 0.498 Neutral MSH6 P52701 L996V 996 L V 0.088 Neutral MSH6 P52701 L996W 996 L W 0.764 Pathogenic MSH6 P52701 L996Y 996 L Y 0.748 Pathogenic MSH6 P52701 K997A 997 K A 0.216 Neutral MSH6 P52701 K997C 997 K C 0.022 Neutral MSH6 P52701 K997D 997 K D 0.268 Neutral MSH6 P52701 K997E 997 K E 0.024 Neutral MSH6 P52701 K997F 997 K F 0.802 Pathogenic MSH6 P52701 K997G 997 K G 0.328 Neutral MSH6 P52701 K997H 997 K H 0.164 Neutral MSH6 P52701 K997I 997 K I 0.234 Neutral MSH6 P52701 K997L 997 K L 0.418 Neutral MSH6 P52701 K997M 997 K M 0.054 Neutral MSH6 P52701 K997N 997 K N 0.314 Neutral MSH6 P52701 K997P 997 K P 0.796 Pathogenic MSH6 P52701 K997Q 997 K Q 0.032 Neutral MSH6 P52701 K997R 997 K R 0.032 Neutral MSH6 P52701 K997S 997 K S 0.042 Neutral MSH6 P52701 K997T 997 K T 0.036 Neutral MSH6 P52701 K997V 997 K V 0.744 Pathogenic MSH6 P52701 K997W 997 K W 0.976 Pathogenic MSH6 P52701 K997Y 997 K Y 0.92 Pathogenic MSH6 P52701 S998A 998 S A 0.478 Neutral MSH6 P52701 S998C 998 S C 0.896 Pathogenic MSH6 P52701 S998D 998 S D 0.904 Pathogenic MSH6 P52701 S998E 998 S E 0.958 Pathogenic MSH6 P52701 S998F 998 S F 0.982 Pathogenic MSH6 P52701 S998G 998 S G 0.162 Neutral MSH6 P52701 S998H 998 S H 0.974 Pathogenic MSH6 P52701 S998I 998 S I 0.882 Pathogenic MSH6 P52701 S998K 998 S K 0.954 Pathogenic MSH6 P52701 S998L 998 S L 0.922 Pathogenic MSH6 P52701 S998M 998 S M 0.998 Pathogenic MSH6 P52701 S998N 998 S N 0.394 Neutral MSH6 P52701 S998P 998 S P 0.968 Pathogenic MSH6 P52701 S998Q 998 S Q 0.946 Pathogenic MSH6 P52701 S998R 998 S R 0.972 Pathogenic MSH6 P52701 S998T 998 S T 0.734 Pathogenic MSH6 P52701 S998V 998 S V 0.946 Pathogenic MSH6 P52701 S998W 998 S W 0.936 Pathogenic MSH6 P52701 S998Y 998 S Y 0.944 Pathogenic MSH6 P52701 T999A 999 T A 0.05 Neutral MSH6 P52701 T999C 999 T C 0.268 Neutral MSH6 P52701 T999D 999 T D 0.308 Neutral MSH6 P52701 T999E 999 T E 0.632 Pathogenic MSH6 P52701 T999F 999 T F 0.758 Pathogenic MSH6 P52701 T999G 999 T G 0.044 Neutral MSH6 P52701 T999H 999 T H 0.382 Neutral MSH6 P52701 T999I 999 T I 0.456 Neutral MSH6 P52701 T999K 999 T K 0.11 Neutral MSH6 P52701 T999L 999 T L 0.438 Neutral MSH6 P52701 T999M 999 T M 0.702 Pathogenic MSH6 P52701 T999N 999 T N 0.342 Neutral MSH6 P52701 T999P 999 T P 0.642 Pathogenic MSH6 P52701 T999Q 999 T Q 0.042 Neutral MSH6 P52701 T999R 999 T R 0.482 Neutral MSH6 P52701 T999S 999 T S 0.022 Neutral MSH6 P52701 T999V 999 T V 0.736 Pathogenic MSH6 P52701 T999W 999 T W 0.946 Pathogenic MSH6 P52701 T999Y 999 T Y 0.942 Pathogenic PMS2 P54278 M1A 1 M A 0.046 Neutral PMS2 P54278 M1C 1 M C 0.042 Neutral PMS2 P54278 M1D 1 M D 0.162 Neutral PMS2 P54278 M1E 1 M E 0.008 Neutral PMS2 P54278 M1F 1 M F 0.136 Neutral PMS2 P54278 M1G 1 M G 0.136 Neutral PMS2 P54278 M1H 1 M H 0.022 Neutral PMS2 P54278 M1I 1 M I 0.06 Neutral PMS2 P54278 M1K 1 M K 0.018 Neutral PMS2 P54278 M1L 1 M L 0.004 Neutral PMS2 P54278 M1N 1 M N 0.18 Neutral PMS2 P54278 M1P 1 M P 0.034 Neutral PMS2 P54278 M1Q 1 M Q 0.042 Neutral PMS2 P54278 M1R 1 M R 0.122 Neutral PMS2 P54278 M1S 1 M S 0.018 Neutral PMS2 P54278 M1T 1 M T 0.082 Neutral PMS2 P54278 M1V 1 M V 0.132 Neutral PMS2 P54278 M1W 1 M W 0.422 Neutral PMS2 P54278 M1Y 1 M Y 0.348 Neutral PMS2 P54278 E10A 10 E A 0.076 Neutral PMS2 P54278 E10C 10 E C 0.108 Neutral PMS2 P54278 E10D 10 E D 0.07 Neutral PMS2 P54278 E10F 10 E F 0.424 Neutral PMS2 P54278 E10G 10 E G 0.024 Neutral PMS2 P54278 E10H 10 E H 0.164 Neutral PMS2 P54278 E10I 10 E I 0.448 Neutral PMS2 P54278 E10K 10 E K 0.002 Neutral PMS2 P54278 E10L 10 E L 0.112 Neutral PMS2 P54278 E10M 10 E M 0.032 Neutral PMS2 P54278 E10N 10 E N 0.046 Neutral PMS2 P54278 E10P 10 E P 0.46 Neutral PMS2 P54278 E10Q 10 E Q 0 Neutral PMS2 P54278 E10R 10 E R 0.02 Neutral PMS2 P54278 E10S 10 E S 0.016 Neutral PMS2 P54278 E10T 10 E T 0.028 Neutral PMS2 P54278 E10V 10 E V 0.058 Neutral PMS2 P54278 E10W 10 E W 0.696 Pathogenic PMS2 P54278 E10Y 10 E Y 0.582 Pathogenic PMS2 P54278 Q100A 100 Q A 0.442 Neutral PMS2 P54278 Q100C 100 Q C 0.316 Neutral PMS2 P54278 Q100D 100 Q D 0.348 Neutral PMS2 P54278 Q100E 100 Q E 0.03 Neutral PMS2 P54278 Q100F 100 Q F 0.854 Pathogenic PMS2 P54278 Q100G 100 Q G 0.1 Neutral PMS2 P54278 Q100H 100 Q H 0.062 Neutral PMS2 P54278 Q100I 100 Q I 0.398 Neutral PMS2 P54278 Q100K 100 Q K 0.086 Neutral PMS2 P54278 Q100L 100 Q L 0.188 Neutral PMS2 P54278 Q100M 100 Q M 0.09 Neutral PMS2 P54278 Q100N 100 Q N 0.068 Neutral PMS2 P54278 Q100P 100 Q P 0.836 Pathogenic PMS2 P54278 Q100R 100 Q R 0.054 Neutral PMS2 P54278 Q100S 100 Q S 0.09 Neutral PMS2 P54278 Q100T 100 Q T 0.026 Neutral PMS2 P54278 Q100V 100 Q V 0.428 Neutral PMS2 P54278 Q100W 100 Q W 0.894 Pathogenic PMS2 P54278 Q100Y 100 Q Y 0.85 Pathogenic PMS2 P54278 V101A 101 V A 0.392 Neutral PMS2 P54278 V101C 101 V C 0.77 Pathogenic PMS2 P54278 V101D 101 V D 0.848 Pathogenic PMS2 P54278 V101E 101 V E 0.964 Pathogenic PMS2 P54278 V101F 101 V F 0.9 Pathogenic PMS2 P54278 V101G 101 V G 0.894 Pathogenic PMS2 P54278 V101H 101 V H 0.864 Pathogenic PMS2 P54278 V101I 101 V I 0.196 Neutral PMS2 P54278 V101K 101 V K 0.988 Pathogenic PMS2 P54278 V101L 101 V L 0.232 Neutral PMS2 P54278 V101M 101 V M 0.87 Pathogenic PMS2 P54278 V101N 101 V N 0.914 Pathogenic PMS2 P54278 V101P 101 V P 0.982 Pathogenic PMS2 P54278 V101Q 101 V Q 0.972 Pathogenic PMS2 P54278 V101R 101 V R 0.948 Pathogenic PMS2 P54278 V101S 101 V S 0.772 Pathogenic PMS2 P54278 V101T 101 V T 0.83 Pathogenic PMS2 P54278 V101W 101 V W 0.924 Pathogenic PMS2 P54278 V101Y 101 V Y 0.952 Pathogenic PMS2 P54278 E102A 102 E A 0.234 Neutral PMS2 P54278 E102C 102 E C 0.49 Neutral PMS2 P54278 E102D 102 E D 0.068 Neutral PMS2 P54278 E102F 102 E F 0.882 Pathogenic PMS2 P54278 E102G 102 E G 0.05 Neutral PMS2 P54278 E102H 102 E H 0.06 Neutral PMS2 P54278 E102I 102 E I 0.938 Pathogenic PMS2 P54278 E102K 102 E K 0.324 Neutral PMS2 P54278 E102L 102 E L 0.44 Neutral PMS2 P54278 E102M 102 E M 0.658 Pathogenic PMS2 P54278 E102N 102 E N 0.02 Neutral PMS2 P54278 E102P 102 E P 0.394 Neutral PMS2 P54278 E102Q 102 E Q 0.014 Neutral PMS2 P54278 E102R 102 E R 0.138 Neutral PMS2 P54278 E102S 102 E S 0.052 Neutral PMS2 P54278 E102T 102 E T 0.046 Neutral PMS2 P54278 E102V 102 E V 0.092 Neutral PMS2 P54278 E102W 102 E W 0.972 Pathogenic PMS2 P54278 E102Y 102 E Y 0.92 Pathogenic PMS2 P54278 T103A 103 T A 0.696 Pathogenic PMS2 P54278 T103C 103 T C 0.93 Pathogenic PMS2 P54278 T103D 103 T D 0.944 Pathogenic PMS2 P54278 T103E 103 T E 0.948 Pathogenic PMS2 P54278 T103F 103 T F 0.948 Pathogenic PMS2 P54278 T103G 103 T G 0.73 Pathogenic PMS2 P54278 T103H 103 T H 0.914 Pathogenic PMS2 P54278 T103I 103 T I 0.95 Pathogenic PMS2 P54278 T103K 103 T K 0.938 Pathogenic PMS2 P54278 T103L 103 T L 0.948 Pathogenic PMS2 P54278 T103M 103 T M 0.984 Pathogenic PMS2 P54278 T103N 103 T N 0.882 Pathogenic PMS2 P54278 T103P 103 T P 0.958 Pathogenic PMS2 P54278 T103Q 103 T Q 0.204 Neutral PMS2 P54278 T103R 103 T R 0.638 Pathogenic PMS2 P54278 T103S 103 T S 0.174 Neutral PMS2 P54278 T103V 103 T V 0.894 Pathogenic PMS2 P54278 T103W 103 T W 0.988 Pathogenic PMS2 P54278 T103Y 103 T Y 0.988 Pathogenic PMS2 P54278 F104A 104 F A 0.476 Neutral PMS2 P54278 F104C 104 F C 0.67 Pathogenic PMS2 P54278 F104D 104 F D 0.782 Pathogenic PMS2 P54278 F104E 104 F E 0.844 Pathogenic PMS2 P54278 F104G 104 F G 0.476 Neutral PMS2 P54278 F104H 104 F H 0.148 Neutral PMS2 P54278 F104I 104 F I 0.264 Neutral PMS2 P54278 F104K 104 F K 0.828 Pathogenic PMS2 P54278 F104L 104 F L 0.138 Neutral PMS2 P54278 F104M 104 F M 0.744 Pathogenic PMS2 P54278 F104N 104 F N 0.698 Pathogenic PMS2 P54278 F104P 104 F P 0.95 Pathogenic PMS2 P54278 F104Q 104 F Q 0.716 Pathogenic PMS2 P54278 F104R 104 F R 0.908 Pathogenic PMS2 P54278 F104S 104 F S 0.426 Neutral PMS2 P54278 F104T 104 F T 0.598 Pathogenic PMS2 P54278 F104V 104 F V 0.862 Pathogenic PMS2 P54278 F104W 104 F W 0.942 Pathogenic PMS2 P54278 F104Y 104 F Y 0.29 Neutral PMS2 P54278 G105A 105 G A 0.88 Pathogenic PMS2 P54278 G105C 105 G C 0.918 Pathogenic PMS2 P54278 G105D 105 G D 0.958 Pathogenic PMS2 P54278 G105E 105 G E 0.978 Pathogenic PMS2 P54278 G105F 105 G F 0.984 Pathogenic PMS2 P54278 G105H 105 G H 0.984 Pathogenic PMS2 P54278 G105I 105 G I 0.974 Pathogenic PMS2 P54278 G105K 105 G K 0.986 Pathogenic PMS2 P54278 G105L 105 G L 0.984 Pathogenic PMS2 P54278 G105M 105 G M 0.988 Pathogenic PMS2 P54278 G105N 105 G N 0.918 Pathogenic PMS2 P54278 G105P 105 G P 0.97 Pathogenic PMS2 P54278 G105Q 105 G Q 0.964 Pathogenic PMS2 P54278 G105R 105 G R 0.996 Pathogenic PMS2 P54278 G105S 105 G S 0.918 Pathogenic PMS2 P54278 G105T 105 G T 0.898 Pathogenic PMS2 P54278 G105V 105 G V 0.986 Pathogenic PMS2 P54278 G105W 105 G W 0.974 Pathogenic PMS2 P54278 G105Y 105 G Y 0.974 Pathogenic PMS2 P54278 F106A 106 F A 0.414 Neutral PMS2 P54278 F106C 106 F C 0.576 Pathogenic PMS2 P54278 F106D 106 F D 0.814 Pathogenic PMS2 P54278 F106E 106 F E 0.894 Pathogenic PMS2 P54278 F106G 106 F G 0.492 Neutral PMS2 P54278 F106H 106 F H 0.64 Pathogenic PMS2 P54278 F106I 106 F I 0.558 Pathogenic PMS2 P54278 F106K 106 F K 0.864 Pathogenic PMS2 P54278 F106L 106 F L 0.534 Pathogenic PMS2 P54278 F106M 106 F M 0.656 Pathogenic PMS2 P54278 F106N 106 F N 0.732 Pathogenic PMS2 P54278 F106P 106 F P 0.924 Pathogenic PMS2 P54278 F106Q 106 F Q 0.764 Pathogenic PMS2 P54278 F106R 106 F R 0.932 Pathogenic PMS2 P54278 F106S 106 F S 0.742 Pathogenic PMS2 P54278 F106T 106 F T 0.57 Pathogenic PMS2 P54278 F106V 106 F V 0.792 Pathogenic PMS2 P54278 F106W 106 F W 0.914 Pathogenic PMS2 P54278 F106Y 106 F Y 0.566 Pathogenic PMS2 P54278 R107A 107 R A 0.246 Neutral PMS2 P54278 R107C 107 R C 0.956 Pathogenic PMS2 P54278 R107D 107 R D 0.326 Neutral PMS2 P54278 R107E 107 R E 0.302 Neutral PMS2 P54278 R107F 107 R F 0.974 Pathogenic PMS2 P54278 R107G 107 R G 0.436 Neutral PMS2 P54278 R107H 107 R H 0.542 Pathogenic PMS2 P54278 R107I 107 R I 0.976 Pathogenic PMS2 P54278 R107K 107 R K 0.858 Pathogenic PMS2 P54278 R107L 107 R L 0.988 Pathogenic PMS2 P54278 R107M 107 R M 0.8 Pathogenic PMS2 P54278 R107N 107 R N 0.76 Pathogenic PMS2 P54278 R107P 107 R P 0.988 Pathogenic PMS2 P54278 R107Q 107 R Q 0.09 Neutral PMS2 P54278 R107S 107 R S 0.162 Neutral PMS2 P54278 R107T 107 R T 0.944 Pathogenic PMS2 P54278 R107V 107 R V 0.976 Pathogenic PMS2 P54278 R107W 107 R W 0.968 Pathogenic PMS2 P54278 R107Y 107 R Y 0.972 Pathogenic PMS2 P54278 G108A 108 G A 0.302 Neutral PMS2 P54278 G108C 108 G C 0.678 Pathogenic PMS2 P54278 G108D 108 G D 0.974 Pathogenic PMS2 P54278 G108E 108 G E 0.984 Pathogenic PMS2 P54278 G108F 108 G F 0.988 Pathogenic PMS2 P54278 G108H 108 G H 0.906 Pathogenic PMS2 P54278 G108I 108 G I 0.978 Pathogenic PMS2 P54278 G108K 108 G K 0.992 Pathogenic PMS2 P54278 G108L 108 G L 0.988 Pathogenic PMS2 P54278 G108M 108 G M 0.994 Pathogenic PMS2 P54278 G108N 108 G N 0.938 Pathogenic PMS2 P54278 G108P 108 G P 0.982 Pathogenic PMS2 P54278 G108Q 108 G Q 0.978 Pathogenic PMS2 P54278 G108R 108 G R 1 Pathogenic PMS2 P54278 G108S 108 G S 0.296 Neutral PMS2 P54278 G108T 108 G T 0.608 Pathogenic PMS2 P54278 G108V 108 G V 0.99 Pathogenic PMS2 P54278 G108W 108 G W 0.984 Pathogenic PMS2 P54278 G108Y 108 G Y 0.984 Pathogenic PMS2 P54278 E109A 109 E A 0.812 Pathogenic PMS2 P54278 E109C 109 E C 0.758 Pathogenic PMS2 P54278 E109D 109 E D 0.188 Neutral PMS2 P54278 E109F 109 E F 0.964 Pathogenic PMS2 P54278 E109G 109 E G 0.382 Neutral PMS2 P54278 E109H 109 E H 0.576 Pathogenic PMS2 P54278 E109I 109 E I 0.98 Pathogenic PMS2 P54278 E109K 109 E K 0.67 Pathogenic PMS2 P54278 E109L 109 E L 0.972 Pathogenic PMS2 P54278 E109M 109 E M 0.91 Pathogenic PMS2 P54278 E109N 109 E N 0.77 Pathogenic PMS2 P54278 E109P 109 E P 0.934 Pathogenic PMS2 P54278 E109Q 109 E Q 0.85 Pathogenic PMS2 P54278 E109R 109 E R 0.93 Pathogenic PMS2 P54278 E109S 109 E S 0.306 Neutral PMS2 P54278 E109T 109 E T 0.86 Pathogenic PMS2 P54278 E109V 109 E V 0.916 Pathogenic PMS2 P54278 E109W 109 E W 0.978 Pathogenic PMS2 P54278 E109Y 109 E Y 0.958 Pathogenic PMS2 P54278 P11A 11 P A 0.032 Neutral PMS2 P54278 P11C 11 P C 0.028 Neutral PMS2 P54278 P11D 11 P D 0.028 Neutral PMS2 P54278 P11E 11 P E 0.052 Neutral PMS2 P54278 P11F 11 P F 0.252 Neutral PMS2 P54278 P11G 11 P G 0.092 Neutral PMS2 P54278 P11H 11 P H 0.246 Neutral PMS2 P54278 P11I 11 P I 0.046 Neutral PMS2 P54278 P11K 11 P K 0.052 Neutral PMS2 P54278 P11L 11 P L 0.042 Neutral PMS2 P54278 P11M 11 P M 0.146 Neutral PMS2 P54278 P11N 11 P N 0.018 Neutral PMS2 P54278 P11Q 11 P Q 0.096 Neutral PMS2 P54278 P11R 11 P R 0.204 Neutral PMS2 P54278 P11S 11 P S 0.004 Neutral PMS2 P54278 P11T 11 P T 0.012 Neutral PMS2 P54278 P11V 11 P V 0.044 Neutral PMS2 P54278 P11W 11 P W 0.328 Neutral PMS2 P54278 P11Y 11 P Y 0.25 Neutral PMS2 P54278 A110C 110 A C 0.846 Pathogenic PMS2 P54278 A110D 110 A D 0.912 Pathogenic PMS2 P54278 A110E 110 A E 0.57 Pathogenic PMS2 P54278 A110F 110 A F 0.824 Pathogenic PMS2 P54278 A110G 110 A G 0.742 Pathogenic PMS2 P54278 A110H 110 A H 0.852 Pathogenic PMS2 P54278 A110I 110 A I 0.95 Pathogenic PMS2 P54278 A110K 110 A K 0.918 Pathogenic PMS2 P54278 A110L 110 A L 0.964 Pathogenic PMS2 P54278 A110M 110 A M 0.834 Pathogenic PMS2 P54278 A110N 110 A N 0.842 Pathogenic PMS2 P54278 A110P 110 A P 0.964 Pathogenic PMS2 P54278 A110Q 110 A Q 0.808 Pathogenic PMS2 P54278 A110R 110 A R 0.956 Pathogenic PMS2 P54278 A110S 110 A S 0.416 Neutral PMS2 P54278 A110T 110 A T 0.71 Pathogenic PMS2 P54278 A110V 110 A V 0.902 Pathogenic PMS2 P54278 A110W 110 A W 0.96 Pathogenic PMS2 P54278 A110Y 110 A Y 0.954 Pathogenic PMS2 P54278 L111A 111 L A 0.704 Pathogenic PMS2 P54278 L111C 111 L C 0.82 Pathogenic PMS2 P54278 L111D 111 L D 0.892 Pathogenic PMS2 P54278 L111E 111 L E 0.872 Pathogenic PMS2 P54278 L111F 111 L F 0.918 Pathogenic PMS2 P54278 L111G 111 L G 0.824 Pathogenic PMS2 P54278 L111H 111 L H 0.908 Pathogenic PMS2 P54278 L111I 111 L I 0.264 Neutral PMS2 P54278 L111K 111 L K 0.212 Neutral PMS2 P54278 L111M 111 L M 0.682 Pathogenic PMS2 P54278 L111N 111 L N 0.764 Pathogenic PMS2 P54278 L111P 111 L P 0.994 Pathogenic PMS2 P54278 L111Q 111 L Q 0.402 Neutral PMS2 P54278 L111R 111 L R 0.98 Pathogenic PMS2 P54278 L111S 111 L S 0.644 Pathogenic PMS2 P54278 L111T 111 L T 0.604 Pathogenic PMS2 P54278 L111V 111 L V 0.484 Neutral PMS2 P54278 L111W 111 L W 0.902 Pathogenic PMS2 P54278 L111Y 111 L Y 0.884 Pathogenic PMS2 P54278 S112A 112 S A 0.264 Neutral PMS2 P54278 S112C 112 S C 0.852 Pathogenic PMS2 P54278 S112D 112 S D 0.86 Pathogenic PMS2 P54278 S112E 112 S E 0.93 Pathogenic PMS2 P54278 S112F 112 S F 0.684 Pathogenic PMS2 P54278 S112G 112 S G 0.596 Pathogenic PMS2 P54278 S112H 112 S H 0.95 Pathogenic PMS2 P54278 S112I 112 S I 0.884 Pathogenic PMS2 P54278 S112K 112 S K 0.7 Pathogenic PMS2 P54278 S112L 112 S L 0.75 Pathogenic PMS2 P54278 S112M 112 S M 0.998 Pathogenic PMS2 P54278 S112N 112 S N 0.276 Neutral PMS2 P54278 S112P 112 S P 0.95 Pathogenic PMS2 P54278 S112Q 112 S Q 0.908 Pathogenic PMS2 P54278 S112R 112 S R 0.95 Pathogenic PMS2 P54278 S112T 112 S T 0.892 Pathogenic PMS2 P54278 S112V 112 S V 0.968 Pathogenic PMS2 P54278 S112W 112 S W 0.982 Pathogenic PMS2 P54278 S112Y 112 S Y 0.766 Pathogenic PMS2 P54278 S113A 113 S A 0.292 Neutral PMS2 P54278 S113C 113 S C 0.896 Pathogenic PMS2 P54278 S113D 113 S D 0.898 Pathogenic PMS2 P54278 S113E 113 S E 0.954 Pathogenic PMS2 P54278 S113F 113 S F 0.982 Pathogenic PMS2 P54278 S113G 113 S G 0.678 Pathogenic PMS2 P54278 S113H 113 S H 0.972 Pathogenic PMS2 P54278 S113I 113 S I 0.782 Pathogenic PMS2 P54278 S113K 113 S K 0.952 Pathogenic PMS2 P54278 S113L 113 S L 0.926 Pathogenic PMS2 P54278 S113M 113 S M 0.998 Pathogenic PMS2 P54278 S113N 113 S N 0.238 Neutral PMS2 P54278 S113P 113 S P 0.968 Pathogenic PMS2 P54278 S113Q 113 S Q 0.944 Pathogenic PMS2 P54278 S113R 113 S R 0.576 Pathogenic PMS2 P54278 S113T 113 S T 0.872 Pathogenic PMS2 P54278 S113V 113 S V 0.964 Pathogenic PMS2 P54278 S113W 113 S W 0.978 Pathogenic PMS2 P54278 S113Y 113 S Y 0.976 Pathogenic PMS2 P54278 L114A 114 L A 0.698 Pathogenic PMS2 P54278 L114C 114 L C 0.816 Pathogenic PMS2 P54278 L114D 114 L D 0.892 Pathogenic PMS2 P54278 L114E 114 L E 0.872 Pathogenic PMS2 P54278 L114F 114 L F 0.486 Neutral PMS2 P54278 L114G 114 L G 0.814 Pathogenic PMS2 P54278 L114H 114 L H 0.904 Pathogenic PMS2 P54278 L114I 114 L I 0.51 Pathogenic PMS2 P54278 L114K 114 L K 0.738 Pathogenic PMS2 P54278 L114M 114 L M 0.708 Pathogenic PMS2 P54278 L114N 114 L N 0.762 Pathogenic PMS2 P54278 L114P 114 L P 0.99 Pathogenic PMS2 P54278 L114Q 114 L Q 0.732 Pathogenic PMS2 P54278 L114R 114 L R 0.98 Pathogenic PMS2 P54278 L114S 114 L S 0.638 Pathogenic PMS2 P54278 L114T 114 L T 0.6 Pathogenic PMS2 P54278 L114V 114 L V 0.214 Neutral PMS2 P54278 L114W 114 L W 0.922 Pathogenic PMS2 P54278 L114Y 114 L Y 0.642 Pathogenic PMS2 P54278 C115A 115 C A 0.284 Neutral PMS2 P54278 C115D 115 C D 0.946 Pathogenic PMS2 P54278 C115E 115 C E 0.324 Neutral PMS2 P54278 C115F 115 C F 0.966 Pathogenic PMS2 P54278 C115G 115 C G 0.94 Pathogenic PMS2 P54278 C115H 115 C H 0.804 Pathogenic PMS2 P54278 C115I 115 C I 0.952 Pathogenic PMS2 P54278 C115K 115 C K 0.726 Pathogenic PMS2 P54278 C115L 115 C L 0.956 Pathogenic PMS2 P54278 C115M 115 C M 0.712 Pathogenic PMS2 P54278 C115N 115 C N 0.362 Neutral PMS2 P54278 C115P 115 C P 0.97 Pathogenic PMS2 P54278 C115Q 115 C Q 0.608 Pathogenic PMS2 P54278 C115R 115 C R 1 Pathogenic PMS2 P54278 C115S 115 C S 0.194 Neutral PMS2 P54278 C115T 115 C T 0.674 Pathogenic PMS2 P54278 C115V 115 C V 0.68 Pathogenic PMS2 P54278 C115W 115 C W 0.976 Pathogenic PMS2 P54278 C115Y 115 C Y 0.962 Pathogenic PMS2 P54278 A116C 116 A C 0.254 Neutral PMS2 P54278 A116D 116 A D 0.672 Pathogenic PMS2 P54278 A116E 116 A E 0.76 Pathogenic PMS2 P54278 A116F 116 A F 0.862 Pathogenic PMS2 P54278 A116G 116 A G 0.064 Neutral PMS2 P54278 A116H 116 A H 0.562 Pathogenic PMS2 P54278 A116I 116 A I 0.888 Pathogenic PMS2 P54278 A116K 116 A K 0.572 Pathogenic PMS2 P54278 A116L 116 A L 0.872 Pathogenic PMS2 P54278 A116M 116 A M 0.546 Pathogenic PMS2 P54278 A116N 116 A N 0.612 Pathogenic PMS2 P54278 A116P 116 A P 0.866 Pathogenic PMS2 P54278 A116Q 116 A Q 0.68 Pathogenic PMS2 P54278 A116R 116 A R 0.628 Pathogenic PMS2 P54278 A116S 116 A S 0.022 Neutral PMS2 P54278 A116T 116 A T 0.054 Neutral PMS2 P54278 A116V 116 A V 0.7 Pathogenic PMS2 P54278 A116W 116 A W 0.92 Pathogenic PMS2 P54278 A116Y 116 A Y 0.898 Pathogenic PMS2 P54278 L117A 117 L A 0.422 Neutral PMS2 P54278 L117C 117 L C 0.822 Pathogenic PMS2 P54278 L117D 117 L D 0.91 Pathogenic PMS2 P54278 L117E 117 L E 0.668 Pathogenic PMS2 P54278 L117F 117 L F 0.796 Pathogenic PMS2 P54278 L117G 117 L G 0.864 Pathogenic PMS2 P54278 L117H 117 L H 0.91 Pathogenic PMS2 P54278 L117I 117 L I 0.442 Neutral PMS2 P54278 L117K 117 L K 0.728 Pathogenic PMS2 P54278 L117M 117 L M 0.61 Pathogenic PMS2 P54278 L117N 117 L N 0.82 Pathogenic PMS2 P54278 L117P 117 L P 0.852 Pathogenic PMS2 P54278 L117Q 117 L Q 0.444 Neutral PMS2 P54278 L117R 117 L R 0.986 Pathogenic PMS2 P54278 L117S 117 L S 0.706 Pathogenic PMS2 P54278 L117T 117 L T 0.628 Pathogenic PMS2 P54278 L117V 117 L V 0.27 Neutral PMS2 P54278 L117W 117 L W 0.88 Pathogenic PMS2 P54278 L117Y 117 L Y 0.89 Pathogenic PMS2 P54278 S118A 118 S A 0.128 Neutral PMS2 P54278 S118C 118 S C 0.222 Neutral PMS2 P54278 S118D 118 S D 0.762 Pathogenic PMS2 P54278 S118E 118 S E 0.662 Pathogenic PMS2 P54278 S118F 118 S F 0.97 Pathogenic PMS2 P54278 S118G 118 S G 0.078 Neutral PMS2 P54278 S118H 118 S H 0.912 Pathogenic PMS2 P54278 S118I 118 S I 0.82 Pathogenic PMS2 P54278 S118K 118 S K 0.542 Pathogenic PMS2 P54278 S118L 118 S L 0.846 Pathogenic PMS2 P54278 S118M 118 S M 0.99 Pathogenic PMS2 P54278 S118N 118 S N 0.182 Neutral PMS2 P54278 S118P 118 S P 0.876 Pathogenic PMS2 P54278 S118Q 118 S Q 0.466 Neutral PMS2 P54278 S118R 118 S R 0.558 Pathogenic PMS2 P54278 S118T 118 S T 0.34 Neutral PMS2 P54278 S118V 118 S V 0.868 Pathogenic PMS2 P54278 S118W 118 S W 0.942 Pathogenic PMS2 P54278 S118Y 118 S Y 0.914 Pathogenic PMS2 P54278 D119A 119 D A 0.422 Neutral PMS2 P54278 D119C 119 D C 0.686 Pathogenic PMS2 P54278 D119E 119 D E 0.018 Neutral PMS2 P54278 D119F 119 D F 0.25 Neutral PMS2 P54278 D119G 119 D G 0.464 Neutral PMS2 P54278 D119H 119 D H 0.048 Neutral PMS2 P54278 D119I 119 D I 0.824 Pathogenic PMS2 P54278 D119K 119 D K 0.166 Neutral PMS2 P54278 D119L 119 D L 0.082 Neutral PMS2 P54278 D119M 119 D M 0.078 Neutral PMS2 P54278 D119N 119 D N 0.004 Neutral PMS2 P54278 D119P 119 D P 0.772 Pathogenic PMS2 P54278 D119Q 119 D Q 0.452 Neutral PMS2 P54278 D119R 119 D R 0.566 Pathogenic PMS2 P54278 D119S 119 D S 0.008 Neutral PMS2 P54278 D119T 119 D T 0.026 Neutral PMS2 P54278 D119V 119 D V 0.108 Neutral PMS2 P54278 D119W 119 D W 0.934 Pathogenic PMS2 P54278 D119Y 119 D Y 0.926 Pathogenic PMS2 P54278 A12C 12 A C 0.324 Neutral PMS2 P54278 A12D 12 A D 0.466 Neutral PMS2 P54278 A12E 12 A E 0.382 Neutral PMS2 P54278 A12F 12 A F 0.734 Pathogenic PMS2 P54278 A12G 12 A G 0.006 Neutral PMS2 P54278 A12H 12 A H 0.336 Neutral PMS2 P54278 A12I 12 A I 0.734 Pathogenic PMS2 P54278 A12K 12 A K 0.38 Neutral PMS2 P54278 A12L 12 A L 0.516 Pathogenic PMS2 P54278 A12M 12 A M 0.496 Neutral PMS2 P54278 A12N 12 A N 0.528 Pathogenic PMS2 P54278 A12P 12 A P 0.514 Pathogenic PMS2 P54278 A12Q 12 A Q 0.344 Neutral PMS2 P54278 A12R 12 A R 0.424 Neutral PMS2 P54278 A12S 12 A S 0.004 Neutral PMS2 P54278 A12T 12 A T 0.026 Neutral PMS2 P54278 A12V 12 A V 0.448 Neutral PMS2 P54278 A12W 12 A W 0.768 Pathogenic PMS2 P54278 A12Y 12 A Y 0.774 Pathogenic PMS2 P54278 V120A 120 V A 0.018 Neutral PMS2 P54278 V120C 120 V C 0.242 Neutral PMS2 P54278 V120D 120 V D 0.62 Pathogenic PMS2 P54278 V120E 120 V E 0.514 Pathogenic PMS2 P54278 V120F 120 V F 0.622 Pathogenic PMS2 P54278 V120G 120 V G 0.24 Neutral PMS2 P54278 V120H 120 V H 0.172 Neutral PMS2 P54278 V120I 120 V I 0.068 Neutral PMS2 P54278 V120K 120 V K 0.63 Pathogenic PMS2 P54278 V120L 120 V L 0.044 Neutral PMS2 P54278 V120M 120 V M 0.506 Pathogenic PMS2 P54278 V120N 120 V N 0.204 Neutral PMS2 P54278 V120P 120 V P 0.87 Pathogenic PMS2 P54278 V120Q 120 V Q 0.134 Neutral PMS2 P54278 V120R 120 V R 0.538 Pathogenic PMS2 P54278 V120S 120 V S 0.036 Neutral PMS2 P54278 V120T 120 V T 0.064 Neutral PMS2 P54278 V120W 120 V W 0.842 Pathogenic PMS2 P54278 V120Y 120 V Y 0.832 Pathogenic PMS2 P54278 T121A 121 T A 0.118 Neutral PMS2 P54278 T121C 121 T C 0.574 Pathogenic PMS2 P54278 T121D 121 T D 0.588 Pathogenic PMS2 P54278 T121E 121 T E 0.174 Neutral PMS2 P54278 T121F 121 T F 0.57 Pathogenic PMS2 P54278 T121G 121 T G 0.324 Neutral PMS2 P54278 T121H 121 T H 0.638 Pathogenic PMS2 P54278 T121I 121 T I 0.12 Neutral PMS2 P54278 T121K 121 T K 0.098 Neutral PMS2 P54278 T121L 121 T L 0.272 Neutral PMS2 P54278 T121M 121 T M 0.244 Neutral PMS2 P54278 T121N 121 T N 0.04 Neutral PMS2 P54278 T121P 121 T P 0.686 Pathogenic PMS2 P54278 T121Q 121 T Q 0.046 Neutral PMS2 P54278 T121R 121 T R 0.528 Pathogenic PMS2 P54278 T121S 121 T S 0.016 Neutral PMS2 P54278 T121V 121 T V 0.196 Neutral PMS2 P54278 T121W 121 T W 0.952 Pathogenic PMS2 P54278 T121Y 121 T Y 0.948 Pathogenic PMS2 P54278 I122A 122 I A 0.262 Neutral PMS2 P54278 I122C 122 I C 0.286 Neutral PMS2 P54278 I122D 122 I D 0.612 Pathogenic PMS2 P54278 I122E 122 I E 0.086 Neutral PMS2 P54278 I122F 122 I F 0.212 Neutral PMS2 P54278 I122G 122 I G 0.588 Pathogenic PMS2 P54278 I122H 122 I H 0.27 Neutral PMS2 P54278 I122K 122 I K 0.608 Pathogenic PMS2 P54278 I122L 122 I L 0.052 Neutral PMS2 P54278 I122M 122 I M 0.048 Neutral PMS2 P54278 I122N 122 I N 0.656 Pathogenic PMS2 P54278 I122P 122 I P 0.756 Pathogenic PMS2 P54278 I122Q 122 I Q 0.148 Neutral PMS2 P54278 I122R 122 I R 0.83 Pathogenic PMS2 P54278 I122S 122 I S 0.136 Neutral PMS2 P54278 I122T 122 I T 0.02 Neutral PMS2 P54278 I122V 122 I V 0.004 Neutral PMS2 P54278 I122W 122 I W 0.904 Pathogenic PMS2 P54278 I122Y 122 I Y 0.902 Pathogenic PMS2 P54278 S123A 123 S A 0.554 Pathogenic PMS2 P54278 S123C 123 S C 0.504 Pathogenic PMS2 P54278 S123D 123 S D 0.378 Neutral PMS2 P54278 S123E 123 S E 0.474 Neutral PMS2 P54278 S123F 123 S F 0.578 Pathogenic PMS2 P54278 S123G 123 S G 0.39 Neutral PMS2 P54278 S123H 123 S H 0.578 Pathogenic PMS2 P54278 S123I 123 S I 0.36 Neutral PMS2 P54278 S123K 123 S K 0.45 Neutral PMS2 P54278 S123L 123 S L 0.538 Pathogenic PMS2 P54278 S123M 123 S M 0.982 Pathogenic PMS2 P54278 S123N 123 S N 0.05 Neutral PMS2 P54278 S123P 123 S P 0.66 Pathogenic PMS2 P54278 S123Q 123 S Q 0.48 Neutral PMS2 P54278 S123R 123 S R 0.51 Pathogenic PMS2 P54278 S123T 123 S T 0.214 Neutral PMS2 P54278 S123V 123 S V 0.09 Neutral PMS2 P54278 S123W 123 S W 0.954 Pathogenic PMS2 P54278 S123Y 123 S Y 0.936 Pathogenic PMS2 P54278 T124A 124 T A 0.084 Neutral PMS2 P54278 T124C 124 T C 0.088 Neutral PMS2 P54278 T124D 124 T D 0.474 Neutral PMS2 P54278 T124E 124 T E 0.564 Pathogenic PMS2 P54278 T124F 124 T F 0.698 Pathogenic PMS2 P54278 T124G 124 T G 0.058 Neutral PMS2 P54278 T124H 124 T H 0.208 Neutral PMS2 P54278 T124I 124 T I 0.162 Neutral PMS2 P54278 T124K 124 T K 0.104 Neutral PMS2 P54278 T124L 124 T L 0.446 Neutral PMS2 P54278 T124M 124 T M 0.636 Pathogenic PMS2 P54278 T124N 124 T N 0.028 Neutral PMS2 P54278 T124P 124 T P 0.528 Pathogenic PMS2 P54278 T124Q 124 T Q 0.036 Neutral PMS2 P54278 T124R 124 T R 0.458 Neutral PMS2 P54278 T124S 124 T S 0.03 Neutral PMS2 P54278 T124V 124 T V 0.738 Pathogenic PMS2 P54278 T124W 124 T W 0.916 Pathogenic PMS2 P54278 T124Y 124 T Y 0.624 Pathogenic PMS2 P54278 C125A 125 C A 0.246 Neutral PMS2 P54278 C125D 125 C D 0.368 Neutral PMS2 P54278 C125E 125 C E 0.544 Pathogenic PMS2 P54278 C125F 125 C F 0.96 Pathogenic PMS2 P54278 C125G 125 C G 0.526 Pathogenic PMS2 P54278 C125H 125 C H 0.242 Neutral PMS2 P54278 C125I 125 C I 0.804 Pathogenic PMS2 P54278 C125K 125 C K 0.674 Pathogenic PMS2 P54278 C125L 125 C L 0.832 Pathogenic PMS2 P54278 C125M 125 C M 0.09 Neutral PMS2 P54278 C125N 125 C N 0.364 Neutral PMS2 P54278 C125P 125 C P 0.89 Pathogenic PMS2 P54278 C125Q 125 C Q 0.156 Neutral PMS2 P54278 C125R 125 C R 0.564 Pathogenic PMS2 P54278 C125S 125 C S 0.028 Neutral PMS2 P54278 C125T 125 C T 0.01 Neutral PMS2 P54278 C125V 125 C V 0.782 Pathogenic PMS2 P54278 C125W 125 C W 0.948 Pathogenic PMS2 P54278 C125Y 125 C Y 0.566 Pathogenic PMS2 P54278 H126A 126 H A 0.128 Neutral PMS2 P54278 H126C 126 H C 0.26 Neutral PMS2 P54278 H126D 126 H D 0.158 Neutral PMS2 P54278 H126E 126 H E 0.032 Neutral PMS2 P54278 H126F 126 H F 0.73 Pathogenic PMS2 P54278 H126G 126 H G 0.324 Neutral PMS2 P54278 H126I 126 H I 0.222 Neutral PMS2 P54278 H126K 126 H K 0.042 Neutral PMS2 P54278 H126L 126 H L 0.386 Neutral PMS2 P54278 H126M 126 H M 0.604 Pathogenic PMS2 P54278 H126N 126 H N 0.074 Neutral PMS2 P54278 H126P 126 H P 0.11 Neutral PMS2 P54278 H126Q 126 H Q 0.04 Neutral PMS2 P54278 H126R 126 H R 0.042 Neutral PMS2 P54278 H126S 126 H S 0.046 Neutral PMS2 P54278 H126T 126 H T 0.032 Neutral PMS2 P54278 H126V 126 H V 0.092 Neutral PMS2 P54278 H126W 126 H W 0.954 Pathogenic PMS2 P54278 H126Y 126 H Y 0.758 Pathogenic PMS2 P54278 A127C 127 A C 0.652 Pathogenic PMS2 P54278 A127D 127 A D 0.628 Pathogenic PMS2 P54278 A127E 127 A E 0.55 Pathogenic PMS2 P54278 A127F 127 A F 0.934 Pathogenic PMS2 P54278 A127G 127 A G 0.016 Neutral PMS2 P54278 A127H 127 A H 0.822 Pathogenic PMS2 P54278 A127I 127 A I 0.926 Pathogenic PMS2 P54278 A127K 127 A K 0.526 Pathogenic PMS2 P54278 A127L 127 A L 0.594 Pathogenic PMS2 P54278 A127M 127 A M 0.674 Pathogenic PMS2 P54278 A127N 127 A N 0.552 Pathogenic PMS2 P54278 A127P 127 A P 0.824 Pathogenic PMS2 P54278 A127Q 127 A Q 0.6 Pathogenic PMS2 P54278 A127R 127 A R 0.878 Pathogenic PMS2 P54278 A127S 127 A S 0.008 Neutral PMS2 P54278 A127T 127 A T 0.038 Neutral PMS2 P54278 A127V 127 A V 0.122 Neutral PMS2 P54278 A127W 127 A W 0.926 Pathogenic PMS2 P54278 A127Y 127 A Y 0.64 Pathogenic PMS2 P54278 S128A 128 S A 0.076 Neutral PMS2 P54278 S128C 128 S C 0.364 Neutral PMS2 P54278 S128D 128 S D 0.082 Neutral PMS2 P54278 S128E 128 S E 0.424 Neutral PMS2 P54278 S128F 128 S F 0.68 Pathogenic PMS2 P54278 S128G 128 S G 0.346 Neutral PMS2 P54278 S128H 128 S H 0.662 Pathogenic PMS2 P54278 S128I 128 S I 0.342 Neutral PMS2 P54278 S128K 128 S K 0.612 Pathogenic PMS2 P54278 S128L 128 S L 0.144 Neutral PMS2 P54278 S128M 128 S M 0.938 Pathogenic PMS2 P54278 S128N 128 S N 0.106 Neutral PMS2 P54278 S128P 128 S P 0.504 Pathogenic PMS2 P54278 S128Q 128 S Q 0.438 Neutral PMS2 P54278 S128R 128 S R 0.754 Pathogenic PMS2 P54278 S128T 128 S T 0.056 Neutral PMS2 P54278 S128V 128 S V 0.088 Neutral PMS2 P54278 S128W 128 S W 0.932 Pathogenic PMS2 P54278 S128Y 128 S Y 0.902 Pathogenic PMS2 P54278 A129C 129 A C 0.164 Neutral PMS2 P54278 A129D 129 A D 0.59 Pathogenic PMS2 P54278 A129E 129 A E 0.516 Pathogenic PMS2 P54278 A129F 129 A F 0.894 Pathogenic PMS2 P54278 A129G 129 A G 0.11 Neutral PMS2 P54278 A129H 129 A H 0.464 Neutral PMS2 P54278 A129I 129 A I 0.548 Pathogenic PMS2 P54278 A129K 129 A K 0.49 Neutral PMS2 P54278 A129L 129 A L 0.518 Pathogenic PMS2 P54278 A129M 129 A M 0.724 Pathogenic PMS2 P54278 A129N 129 A N 0.534 Pathogenic PMS2 P54278 A129P 129 A P 0.098 Neutral PMS2 P54278 A129Q 129 A Q 0.464 Neutral PMS2 P54278 A129R 129 A R 0.536 Pathogenic PMS2 P54278 A129S 129 A S 0.04 Neutral PMS2 P54278 A129T 129 A T 0.054 Neutral PMS2 P54278 A129V 129 A V 0.092 Neutral PMS2 P54278 A129W 129 A W 0.888 Pathogenic PMS2 P54278 A129Y 129 A Y 0.54 Pathogenic PMS2 P54278 K13A 13 K A 0.032 Neutral PMS2 P54278 K13C 13 K C 0.056 Neutral PMS2 P54278 K13D 13 K D 0.054 Neutral PMS2 P54278 K13E 13 K E 0.004 Neutral PMS2 P54278 K13F 13 K F 0.364 Neutral PMS2 P54278 K13G 13 K G 0.048 Neutral PMS2 P54278 K13H 13 K H 0.004 Neutral PMS2 P54278 K13I 13 K I 0.186 Neutral PMS2 P54278 K13L 13 K L 0.16 Neutral PMS2 P54278 K13M 13 K M 0.19 Neutral PMS2 P54278 K13N 13 K N 0.056 Neutral PMS2 P54278 K13P 13 K P 0.024 Neutral PMS2 P54278 K13Q 13 K Q 0.01 Neutral PMS2 P54278 K13R 13 K R 0.006 Neutral PMS2 P54278 K13S 13 K S 0.016 Neutral PMS2 P54278 K13T 13 K T 0.014 Neutral PMS2 P54278 K13V 13 K V 0.038 Neutral PMS2 P54278 K13W 13 K W 0.678 Pathogenic PMS2 P54278 K13Y 13 K Y 0.582 Pathogenic PMS2 P54278 K130A 130 K A 0.036 Neutral PMS2 P54278 K130C 130 K C 0.06 Neutral PMS2 P54278 K130D 130 K D 0.064 Neutral PMS2 P54278 K130E 130 K E 0.016 Neutral PMS2 P54278 K130F 130 K F 0.348 Neutral PMS2 P54278 K130G 130 K G 0.18 Neutral PMS2 P54278 K130H 130 K H 0.086 Neutral PMS2 P54278 K130I 130 K I 0.072 Neutral PMS2 P54278 K130L 130 K L 0.36 Neutral PMS2 P54278 K130M 130 K M 0.184 Neutral PMS2 P54278 K130N 130 K N 0.068 Neutral PMS2 P54278 K130P 130 K P 0.028 Neutral PMS2 P54278 K130Q 130 K Q 0.014 Neutral PMS2 P54278 K130R 130 K R 0.058 Neutral PMS2 P54278 K130S 130 K S 0.02 Neutral PMS2 P54278 K130T 130 K T 0.11 Neutral PMS2 P54278 K130V 130 K V 0.288 Neutral PMS2 P54278 K130W 130 K W 0.66 Pathogenic PMS2 P54278 K130Y 130 K Y 0.566 Pathogenic PMS2 P54278 V131A 131 V A 0.028 Neutral PMS2 P54278 V131C 131 V C 0.326 Neutral PMS2 P54278 V131D 131 V D 0.534 Pathogenic PMS2 P54278 V131E 131 V E 0.642 Pathogenic PMS2 P54278 V131F 131 V F 0.628 Pathogenic PMS2 P54278 V131G 131 V G 0.62 Pathogenic PMS2 P54278 V131H 131 V H 0.124 Neutral PMS2 P54278 V131I 131 V I 0.03 Neutral PMS2 P54278 V131K 131 V K 0.134 Neutral PMS2 P54278 V131L 131 V L 0.33 Neutral PMS2 P54278 V131M 131 V M 0.042 Neutral PMS2 P54278 V131N 131 V N 0.144 Neutral PMS2 P54278 V131P 131 V P 0.746 Pathogenic PMS2 P54278 V131Q 131 V Q 0.604 Pathogenic PMS2 P54278 V131R 131 V R 0.76 Pathogenic PMS2 P54278 V131S 131 V S 0.096 Neutral PMS2 P54278 V131T 131 V T 0.06 Neutral PMS2 P54278 V131W 131 V W 0.648 Pathogenic PMS2 P54278 V131Y 131 V Y 0.38 Neutral PMS2 P54278 G132A 132 G A 0.08 Neutral PMS2 P54278 G132C 132 G C 0.81 Pathogenic PMS2 P54278 G132D 132 G D 0.846 Pathogenic PMS2 P54278 G132E 132 G E 0.954 Pathogenic PMS2 P54278 G132F 132 G F 0.972 Pathogenic PMS2 P54278 G132H 132 G H 0.966 Pathogenic PMS2 P54278 G132I 132 G I 0.958 Pathogenic PMS2 P54278 G132K 132 G K 0.912 Pathogenic PMS2 P54278 G132L 132 G L 0.968 Pathogenic PMS2 P54278 G132M 132 G M 0.984 Pathogenic PMS2 P54278 G132N 132 G N 0.64 Pathogenic PMS2 P54278 G132P 132 G P 0.928 Pathogenic PMS2 P54278 G132Q 132 G Q 0.866 Pathogenic PMS2 P54278 G132R 132 G R 0.986 Pathogenic PMS2 P54278 G132S 132 G S 0.712 Pathogenic PMS2 P54278 G132T 132 G T 0.846 Pathogenic PMS2 P54278 G132V 132 G V 0.974 Pathogenic PMS2 P54278 G132W 132 G W 0.956 Pathogenic PMS2 P54278 G132Y 132 G Y 0.946 Pathogenic PMS2 P54278 T133A 133 T A 0.052 Neutral PMS2 P54278 T133C 133 T C 0.496 Neutral PMS2 P54278 T133D 133 T D 0.518 Pathogenic PMS2 P54278 T133E 133 T E 0.63 Pathogenic PMS2 P54278 T133F 133 T F 0.466 Neutral PMS2 P54278 T133G 133 T G 0.278 Neutral PMS2 P54278 T133H 133 T H 0.206 Neutral PMS2 P54278 T133I 133 T I 0.148 Neutral PMS2 P54278 T133K 133 T K 0.292 Neutral PMS2 P54278 T133L 133 T L 0.088 Neutral PMS2 P54278 T133M 133 T M 0.698 Pathogenic PMS2 P54278 T133N 133 T N 0.03 Neutral PMS2 P54278 T133P 133 T P 0.638 Pathogenic PMS2 P54278 T133Q 133 T Q 0.18 Neutral PMS2 P54278 T133R 133 T R 0.842 Pathogenic PMS2 P54278 T133S 133 T S 0.01 Neutral PMS2 P54278 T133V 133 T V 0.082 Neutral PMS2 P54278 T133W 133 T W 0.922 Pathogenic PMS2 P54278 T133Y 133 T Y 0.912 Pathogenic PMS2 P54278 R134A 134 R A 0.39 Neutral PMS2 P54278 R134C 134 R C 0.62 Pathogenic PMS2 P54278 R134D 134 R D 0.292 Neutral PMS2 P54278 R134E 134 R E 0.304 Neutral PMS2 P54278 R134F 134 R F 0.848 Pathogenic PMS2 P54278 R134G 134 R G 0.22 Neutral PMS2 P54278 R134H 134 R H 0.014 Neutral PMS2 P54278 R134I 134 R I 0.288 Neutral PMS2 P54278 R134K 134 R K 0.042 Neutral PMS2 P54278 R134L 134 R L 0.102 Neutral PMS2 P54278 R134M 134 R M 0.624 Pathogenic PMS2 P54278 R134N 134 R N 0.258 Neutral PMS2 P54278 R134P 134 R P 0.784 Pathogenic PMS2 P54278 R134Q 134 R Q 0.488 Neutral PMS2 P54278 R134S 134 R S 0.434 Neutral PMS2 P54278 R134T 134 R T 0.518 Pathogenic PMS2 P54278 R134V 134 R V 0.122 Neutral PMS2 P54278 R134W 134 R W 0.85 Pathogenic PMS2 P54278 R134Y 134 R Y 0.81 Pathogenic PMS2 P54278 L135A 135 L A 0.32 Neutral PMS2 P54278 L135C 135 L C 0.41 Neutral PMS2 P54278 L135D 135 L D 0.678 Pathogenic PMS2 P54278 L135E 135 L E 0.634 Pathogenic PMS2 P54278 L135F 135 L F 0.786 Pathogenic PMS2 P54278 L135G 135 L G 0.58 Pathogenic PMS2 P54278 L135H 135 L H 0.434 Neutral PMS2 P54278 L135I 135 L I 0.038 Neutral PMS2 P54278 L135K 135 L K 0.48 Neutral PMS2 P54278 L135M 135 L M 0.388 Neutral PMS2 P54278 L135N 135 L N 0.622 Pathogenic PMS2 P54278 L135P 135 L P 0.946 Pathogenic PMS2 P54278 L135Q 135 L Q 0.194 Neutral PMS2 P54278 L135R 135 L R 0.87 Pathogenic PMS2 P54278 L135S 135 L S 0.368 Neutral PMS2 P54278 L135T 135 L T 0.376 Neutral PMS2 P54278 L135V 135 L V 0.004 Neutral PMS2 P54278 L135W 135 L W 0.84 Pathogenic PMS2 P54278 L135Y 135 L Y 0.832 Pathogenic PMS2 P54278 M136A 136 M A 0.068 Neutral PMS2 P54278 M136C 136 M C 0.106 Neutral PMS2 P54278 M136D 136 M D 0.066 Neutral PMS2 P54278 M136E 136 M E 0.01 Neutral PMS2 P54278 M136F 136 M F 0.424 Neutral PMS2 P54278 M136G 136 M G 0.2 Neutral PMS2 P54278 M136H 136 M H 0.094 Neutral PMS2 P54278 M136I 136 M I 0.048 Neutral PMS2 P54278 M136K 136 M K 0.032 Neutral PMS2 P54278 M136L 136 M L 0.218 Neutral PMS2 P54278 M136N 136 M N 0.344 Neutral PMS2 P54278 M136P 136 M P 0.494 Neutral PMS2 P54278 M136Q 136 M Q 0.018 Neutral PMS2 P54278 M136R 136 M R 0.334 Neutral PMS2 P54278 M136S 136 M S 0.016 Neutral PMS2 P54278 M136T 136 M T 0.012 Neutral PMS2 P54278 M136V 136 M V 0.212 Neutral PMS2 P54278 M136W 136 M W 0.752 Pathogenic PMS2 P54278 M136Y 136 M Y 0.612 Pathogenic PMS2 P54278 F137A 137 F A 0.242 Neutral PMS2 P54278 F137C 137 F C 0.292 Neutral PMS2 P54278 F137D 137 F D 0.572 Pathogenic PMS2 P54278 F137E 137 F E 0.662 Pathogenic PMS2 P54278 F137G 137 F G 0.36 Neutral PMS2 P54278 F137H 137 F H 0.334 Neutral PMS2 P54278 F137I 137 F I 0.292 Neutral PMS2 P54278 F137K 137 F K 0.508 Pathogenic PMS2 P54278 F137L 137 F L 0.02 Neutral PMS2 P54278 F137M 137 F M 0.348 Neutral PMS2 P54278 F137N 137 F N 0.56 Pathogenic PMS2 P54278 F137P 137 F P 0.762 Pathogenic PMS2 P54278 F137Q 137 F Q 0.592 Pathogenic PMS2 P54278 F137R 137 F R 0.642 Pathogenic PMS2 P54278 F137S 137 F S 0.452 Neutral PMS2 P54278 F137T 137 F T 0.416 Neutral PMS2 P54278 F137V 137 F V 0.472 Neutral PMS2 P54278 F137W 137 F W 0.866 Pathogenic PMS2 P54278 F137Y 137 F Y 0.036 Neutral PMS2 P54278 D138A 138 D A 0.126 Neutral PMS2 P54278 D138C 138 D C 0.756 Pathogenic PMS2 P54278 D138E 138 D E 0.03 Neutral PMS2 P54278 D138F 138 D F 0.938 Pathogenic PMS2 P54278 D138G 138 D G 0.382 Neutral PMS2 P54278 D138H 138 D H 0.448 Neutral PMS2 P54278 D138I 138 D I 0.908 Pathogenic PMS2 P54278 D138K 138 D K 0.754 Pathogenic PMS2 P54278 D138L 138 D L 0.914 Pathogenic PMS2 P54278 D138M 138 D M 0.816 Pathogenic PMS2 P54278 D138N 138 D N 0.012 Neutral PMS2 P54278 D138P 138 D P 0.824 Pathogenic PMS2 P54278 D138Q 138 D Q 0.492 Neutral PMS2 P54278 D138R 138 D R 0.624 Pathogenic PMS2 P54278 D138S 138 D S 0.488 Neutral PMS2 P54278 D138T 138 D T 0.602 Pathogenic PMS2 P54278 D138V 138 D V 0.936 Pathogenic PMS2 P54278 D138W 138 D W 0.974 Pathogenic PMS2 P54278 D138Y 138 D Y 0.968 Pathogenic PMS2 P54278 H139A 139 H A 0.154 Neutral PMS2 P54278 H139C 139 H C 0.234 Neutral PMS2 P54278 H139D 139 H D 0.206 Neutral PMS2 P54278 H139E 139 H E 0.264 Neutral PMS2 P54278 H139F 139 H F 0.706 Pathogenic PMS2 P54278 H139G 139 H G 0.296 Neutral PMS2 P54278 H139I 139 H I 0.212 Neutral PMS2 P54278 H139K 139 H K 0.044 Neutral PMS2 P54278 H139L 139 H L 0.196 Neutral PMS2 P54278 H139M 139 H M 0.376 Neutral PMS2 P54278 H139N 139 H N 0.06 Neutral PMS2 P54278 H139P 139 H P 0.128 Neutral PMS2 P54278 H139Q 139 H Q 0.026 Neutral PMS2 P54278 H139R 139 H R 0.008 Neutral PMS2 P54278 H139S 139 H S 0.254 Neutral PMS2 P54278 H139T 139 H T 0.024 Neutral PMS2 P54278 H139V 139 H V 0.078 Neutral PMS2 P54278 H139W 139 H W 0.914 Pathogenic PMS2 P54278 H139Y 139 H Y 0.222 Neutral PMS2 P54278 A14C 14 A C 0.356 Neutral PMS2 P54278 A14D 14 A D 0.422 Neutral PMS2 P54278 A14E 14 A E 0.484 Neutral PMS2 P54278 A14F 14 A F 0.722 Pathogenic PMS2 P54278 A14G 14 A G 0.09 Neutral PMS2 P54278 A14H 14 A H 0.314 Neutral PMS2 P54278 A14I 14 A I 0.454 Neutral PMS2 P54278 A14K 14 A K 0.358 Neutral PMS2 P54278 A14L 14 A L 0.406 Neutral PMS2 P54278 A14M 14 A M 0.392 Neutral PMS2 P54278 A14N 14 A N 0.392 Neutral PMS2 P54278 A14P 14 A P 0.072 Neutral PMS2 P54278 A14Q 14 A Q 0.334 Neutral PMS2 P54278 A14R 14 A R 0.548 Pathogenic PMS2 P54278 A14S 14 A S 0.006 Neutral PMS2 P54278 A14T 14 A T 0.02 Neutral PMS2 P54278 A14V 14 A V 0.064 Neutral PMS2 P54278 A14W 14 A W 0.754 Pathogenic PMS2 P54278 A14Y 14 A Y 0.566 Pathogenic PMS2 P54278 N140A 140 N A 0.058 Neutral PMS2 P54278 N140C 140 N C 0.364 Neutral PMS2 P54278 N140D 140 N D 0.012 Neutral PMS2 P54278 N140E 140 N E 0.018 Neutral PMS2 P54278 N140F 140 N F 0.702 Pathogenic PMS2 P54278 N140G 140 N G 0.2 Neutral PMS2 P54278 N140H 140 N H 0.042 Neutral PMS2 P54278 N140I 140 N I 0.608 Pathogenic PMS2 P54278 N140K 140 N K 0.048 Neutral PMS2 P54278 N140L 140 N L 0.594 Pathogenic PMS2 P54278 N140M 140 N M 0.56 Pathogenic PMS2 P54278 N140P 140 N P 0.52 Pathogenic PMS2 P54278 N140Q 140 N Q 0.34 Neutral PMS2 P54278 N140R 140 N R 0.322 Neutral PMS2 P54278 N140S 140 N S 0.02 Neutral PMS2 P54278 N140T 140 N T 0.014 Neutral PMS2 P54278 N140V 140 N V 0.604 Pathogenic PMS2 P54278 N140W 140 N W 0.84 Pathogenic PMS2 P54278 N140Y 140 N Y 0.634 Pathogenic PMS2 P54278 G141A 141 G A 0.88 Pathogenic PMS2 P54278 G141C 141 G C 0.918 Pathogenic PMS2 P54278 G141D 141 G D 0.958 Pathogenic PMS2 P54278 G141E 141 G E 0.978 Pathogenic PMS2 P54278 G141F 141 G F 0.982 Pathogenic PMS2 P54278 G141H 141 G H 0.98 Pathogenic PMS2 P54278 G141I 141 G I 0.972 Pathogenic PMS2 P54278 G141K 141 G K 0.982 Pathogenic PMS2 P54278 G141L 141 G L 0.982 Pathogenic PMS2 P54278 G141M 141 G M 0.988 Pathogenic PMS2 P54278 G141N 141 G N 0.918 Pathogenic PMS2 P54278 G141P 141 G P 0.968 Pathogenic PMS2 P54278 G141Q 141 G Q 0.964 Pathogenic PMS2 P54278 G141R 141 G R 0.996 Pathogenic PMS2 P54278 G141S 141 G S 0.914 Pathogenic PMS2 P54278 G141T 141 G T 0.894 Pathogenic PMS2 P54278 G141V 141 G V 0.982 Pathogenic PMS2 P54278 G141W 141 G W 0.972 Pathogenic PMS2 P54278 G141Y 141 G Y 0.912 Pathogenic PMS2 P54278 K142A 142 K A 0.038 Neutral PMS2 P54278 K142C 142 K C 0.018 Neutral PMS2 P54278 K142D 142 K D 0.114 Neutral PMS2 P54278 K142E 142 K E 0.126 Neutral PMS2 P54278 K142F 142 K F 0.212 Neutral PMS2 P54278 K142G 142 K G 0.216 Neutral PMS2 P54278 K142H 142 K H 0.002 Neutral PMS2 P54278 K142I 142 K I 0.07 Neutral PMS2 P54278 K142L 142 K L 0.054 Neutral PMS2 P54278 K142M 142 K M 0.14 Neutral PMS2 P54278 K142N 142 K N 0.012 Neutral PMS2 P54278 K142P 142 K P 0.42 Neutral PMS2 P54278 K142Q 142 K Q 0.024 Neutral PMS2 P54278 K142R 142 K R 0.008 Neutral PMS2 P54278 K142S 142 K S 0.138 Neutral PMS2 P54278 K142T 142 K T 0.31 Neutral PMS2 P54278 K142V 142 K V 0.046 Neutral PMS2 P54278 K142W 142 K W 0.736 Pathogenic PMS2 P54278 K142Y 142 K Y 0.632 Pathogenic PMS2 P54278 I143A 143 I A 0.188 Neutral PMS2 P54278 I143C 143 I C 0.378 Neutral PMS2 P54278 I143D 143 I D 0.578 Pathogenic PMS2 P54278 I143E 143 I E 0.562 Pathogenic PMS2 P54278 I143F 143 I F 0.692 Pathogenic PMS2 P54278 I143G 143 I G 0.556 Pathogenic PMS2 P54278 I143H 143 I H 0.436 Neutral PMS2 P54278 I143K 143 I K 0.578 Pathogenic PMS2 P54278 I143L 143 I L 0.042 Neutral PMS2 P54278 I143M 143 I M 0.192 Neutral PMS2 P54278 I143N 143 I N 0.622 Pathogenic PMS2 P54278 I143P 143 I P 0.71 Pathogenic PMS2 P54278 I143Q 143 I Q 0.598 Pathogenic PMS2 P54278 I143R 143 I R 0.822 Pathogenic PMS2 P54278 I143S 143 I S 0.42 Neutral PMS2 P54278 I143T 143 I T 0.338 Neutral PMS2 P54278 I143V 143 I V 0.012 Neutral PMS2 P54278 I143W 143 I W 0.898 Pathogenic PMS2 P54278 I143Y 143 I Y 0.904 Pathogenic PMS2 P54278 I144A 144 I A 0.026 Neutral PMS2 P54278 I144C 144 I C 0.14 Neutral PMS2 P54278 I144D 144 I D 0.214 Neutral PMS2 P54278 I144E 144 I E 0.224 Neutral PMS2 P54278 I144F 144 I F 0.332 Neutral PMS2 P54278 I144G 144 I G 0.298 Neutral PMS2 P54278 I144H 144 I H 0.144 Neutral PMS2 P54278 I144K 144 I K 0.054 Neutral PMS2 P54278 I144L 144 I L 0 Neutral PMS2 P54278 I144M 144 I M 0.232 Neutral PMS2 P54278 I144N 144 I N 0.258 Neutral PMS2 P54278 I144P 144 I P 0.244 Neutral PMS2 P54278 I144Q 144 I Q 0.108 Neutral PMS2 P54278 I144R 144 I R 0.344 Neutral PMS2 P54278 I144S 144 I S 0.078 Neutral PMS2 P54278 I144T 144 I T 0.012 Neutral PMS2 P54278 I144V 144 I V 0 Neutral PMS2 P54278 I144W 144 I W 0.532 Pathogenic PMS2 P54278 I144Y 144 I Y 0.49 Neutral PMS2 P54278 Q145A 145 Q A 0.19 Neutral PMS2 P54278 Q145C 145 Q C 0.164 Neutral PMS2 P54278 Q145D 145 Q D 0.086 Neutral PMS2 P54278 Q145E 145 Q E 0.04 Neutral PMS2 P54278 Q145F 145 Q F 0.426 Neutral PMS2 P54278 Q145G 145 Q G 0.22 Neutral PMS2 P54278 Q145H 145 Q H 0.354 Neutral PMS2 P54278 Q145I 145 Q I 0.452 Neutral PMS2 P54278 Q145K 145 Q K 0.022 Neutral PMS2 P54278 Q145L 145 Q L 0.136 Neutral PMS2 P54278 Q145M 145 Q M 0.332 Neutral PMS2 P54278 Q145N 145 Q N 0.112 Neutral PMS2 P54278 Q145P 145 Q P 0.472 Neutral PMS2 P54278 Q145R 145 Q R 0.022 Neutral PMS2 P54278 Q145S 145 Q S 0.046 Neutral PMS2 P54278 Q145T 145 Q T 0.008 Neutral PMS2 P54278 Q145V 145 Q V 0.43 Neutral PMS2 P54278 Q145W 145 Q W 0.676 Pathogenic PMS2 P54278 Q145Y 145 Q Y 0.604 Pathogenic PMS2 P54278 K146A 146 K A 0.038 Neutral PMS2 P54278 K146C 146 K C 0.122 Neutral PMS2 P54278 K146D 146 K D 0.026 Neutral PMS2 P54278 K146E 146 K E 0.006 Neutral PMS2 P54278 K146F 146 K F 0.448 Neutral PMS2 P54278 K146G 146 K G 0.054 Neutral PMS2 P54278 K146H 146 K H 0.12 Neutral PMS2 P54278 K146I 146 K I 0.484 Neutral PMS2 P54278 K146L 146 K L 0.454 Neutral PMS2 P54278 K146M 146 K M 0.378 Neutral PMS2 P54278 K146N 146 K N 0.012 Neutral PMS2 P54278 K146P 146 K P 0.488 Neutral PMS2 P54278 K146Q 146 K Q 0.012 Neutral PMS2 P54278 K146R 146 K R 0.008 Neutral PMS2 P54278 K146S 146 K S 0.022 Neutral PMS2 P54278 K146T 146 K T 0.054 Neutral PMS2 P54278 K146V 146 K V 0.396 Neutral PMS2 P54278 K146W 146 K W 0.76 Pathogenic PMS2 P54278 K146Y 146 K Y 0.65 Pathogenic PMS2 P54278 T147A 147 T A 0.014 Neutral PMS2 P54278 T147C 147 T C 0.168 Neutral PMS2 P54278 T147D 147 T D 0.202 Neutral PMS2 P54278 T147E 147 T E 0.064 Neutral PMS2 P54278 T147F 147 T F 0.534 Pathogenic PMS2 P54278 T147G 147 T G 0.172 Neutral PMS2 P54278 T147H 147 T H 0.312 Neutral PMS2 P54278 T147I 147 T I 0.068 Neutral PMS2 P54278 T147K 147 T K 0.022 Neutral PMS2 P54278 T147L 147 T L 0.03 Neutral PMS2 P54278 T147M 147 T M 0.384 Neutral PMS2 P54278 T147N 147 T N 0.12 Neutral PMS2 P54278 T147P 147 T P 0.346 Neutral PMS2 P54278 T147Q 147 T Q 0.006 Neutral PMS2 P54278 T147R 147 T R 0.478 Neutral PMS2 P54278 T147S 147 T S 0.002 Neutral PMS2 P54278 T147V 147 T V 0.032 Neutral PMS2 P54278 T147W 147 T W 0.838 Pathogenic PMS2 P54278 T147Y 147 T Y 0.802 Pathogenic PMS2 P54278 P148A 148 P A 0.076 Neutral PMS2 P54278 P148C 148 P C 0.534 Pathogenic PMS2 P54278 P148D 148 P D 0.356 Neutral PMS2 P54278 P148E 148 P E 0.116 Neutral PMS2 P54278 P148F 148 P F 0.816 Pathogenic PMS2 P54278 P148G 148 P G 0.054 Neutral PMS2 P54278 P148H 148 P H 0.592 Pathogenic PMS2 P54278 P148I 148 P I 0.594 Pathogenic PMS2 P54278 P148K 148 P K 0.102 Neutral PMS2 P54278 P148L 148 P L 0.582 Pathogenic PMS2 P54278 P148M 148 P M 0.646 Pathogenic PMS2 P54278 P148N 148 P N 0.288 Neutral PMS2 P54278 P148Q 148 P Q 0.114 Neutral PMS2 P54278 P148R 148 P R 0.472 Neutral PMS2 P54278 P148S 148 P S 0.038 Neutral PMS2 P54278 P148T 148 P T 0.06 Neutral PMS2 P54278 P148V 148 P V 0.1 Neutral PMS2 P54278 P148W 148 P W 0.826 Pathogenic PMS2 P54278 P148Y 148 P Y 0.81 Pathogenic PMS2 P54278 Y149A 149 Y A 0.074 Neutral PMS2 P54278 Y149C 149 Y C 0.064 Neutral PMS2 P54278 Y149D 149 Y D 0.258 Neutral PMS2 P54278 Y149E 149 Y E 0.252 Neutral PMS2 P54278 Y149F 149 Y F 0.01 Neutral PMS2 P54278 Y149G 149 Y G 0.144 Neutral PMS2 P54278 Y149H 149 Y H 0.006 Neutral PMS2 P54278 Y149I 149 Y I 0.024 Neutral PMS2 P54278 Y149K 149 Y K 0.024 Neutral PMS2 P54278 Y149L 149 Y L 0.068 Neutral PMS2 P54278 Y149M 149 Y M 0.124 Neutral PMS2 P54278 Y149N 149 Y N 0.188 Neutral PMS2 P54278 Y149P 149 Y P 0.1 Neutral PMS2 P54278 Y149Q 149 Y Q 0.176 Neutral PMS2 P54278 Y149R 149 Y R 0.22 Neutral PMS2 P54278 Y149S 149 Y S 0.106 Neutral PMS2 P54278 Y149T 149 Y T 0.09 Neutral PMS2 P54278 Y149V 149 Y V 0.014 Neutral PMS2 P54278 Y149W 149 Y W 0.106 Neutral PMS2 P54278 I15A 15 I A 0.134 Neutral PMS2 P54278 I15C 15 I C 0.436 Neutral PMS2 P54278 I15D 15 I D 0.506 Pathogenic PMS2 P54278 I15E 15 I E 0.114 Neutral PMS2 P54278 I15F 15 I F 0.3 Neutral PMS2 P54278 I15G 15 I G 0.32 Neutral PMS2 P54278 I15H 15 I H 0.056 Neutral PMS2 P54278 I15K 15 I K 0.126 Neutral PMS2 P54278 I15L 15 I L 0.008 Neutral PMS2 P54278 I15M 15 I M 0.036 Neutral PMS2 P54278 I15N 15 I N 0.15 Neutral PMS2 P54278 I15P 15 I P 0.762 Pathogenic PMS2 P54278 I15Q 15 I Q 0.264 Neutral PMS2 P54278 I15R 15 I R 0.744 Pathogenic PMS2 P54278 I15S 15 I S 0.422 Neutral PMS2 P54278 I15T 15 I T 0.352 Neutral PMS2 P54278 I15V 15 I V 0.008 Neutral PMS2 P54278 I15W 15 I W 0.882 Pathogenic PMS2 P54278 I15Y 15 I Y 0.878 Pathogenic PMS2 P54278 P150A 150 P A 0.1 Neutral PMS2 P54278 P150C 150 P C 0.528 Pathogenic PMS2 P54278 P150D 150 P D 0.35 Neutral PMS2 P54278 P150E 150 P E 0.626 Pathogenic PMS2 P54278 P150F 150 P F 0.796 Pathogenic PMS2 P54278 P150G 150 P G 0.296 Neutral PMS2 P54278 P150H 150 P H 0.588 Pathogenic PMS2 P54278 P150I 150 P I 0.098 Neutral PMS2 P54278 P150K 150 P K 0.598 Pathogenic PMS2 P54278 P150L 150 P L 0.516 Pathogenic PMS2 P54278 P150M 150 P M 0.39 Neutral PMS2 P54278 P150N 150 P N 0.286 Neutral PMS2 P54278 P150Q 150 P Q 0.582 Pathogenic PMS2 P54278 P150R 150 P R 0.776 Pathogenic PMS2 P54278 P150S 150 P S 0.062 Neutral PMS2 P54278 P150T 150 P T 0.066 Neutral PMS2 P54278 P150V 150 P V 0.09 Neutral PMS2 P54278 P150W 150 P W 0.812 Pathogenic PMS2 P54278 P150Y 150 P Y 0.79 Pathogenic PMS2 P54278 R151A 151 R A 0.112 Neutral PMS2 P54278 R151C 151 R C 0.666 Pathogenic PMS2 P54278 R151D 151 R D 0.64 Pathogenic PMS2 P54278 R151E 151 R E 0.558 Pathogenic PMS2 P54278 R151F 151 R F 0.8 Pathogenic PMS2 P54278 R151G 151 R G 0.042 Neutral PMS2 P54278 R151H 151 R H 0.016 Neutral PMS2 P54278 R151I 151 R I 0.904 Pathogenic PMS2 P54278 R151K 151 R K 0.27 Neutral PMS2 P54278 R151L 151 R L 0.716 Pathogenic PMS2 P54278 R151M 151 R M 0.678 Pathogenic PMS2 P54278 R151N 151 R N 0.5 Pathogenic PMS2 P54278 R151P 151 R P 0.848 Pathogenic PMS2 P54278 R151Q 151 R Q 0.436 Neutral PMS2 P54278 R151S 151 R S 0.336 Neutral PMS2 P54278 R151T 151 R T 0.548 Pathogenic PMS2 P54278 R151V 151 R V 0.828 Pathogenic PMS2 P54278 R151W 151 R W 0.914 Pathogenic PMS2 P54278 R151Y 151 R Y 0.896 Pathogenic PMS2 P54278 P152A 152 P A 0.084 Neutral PMS2 P54278 P152C 152 P C 0.566 Pathogenic PMS2 P54278 P152D 152 P D 0.38 Neutral PMS2 P54278 P152E 152 P E 0.126 Neutral PMS2 P54278 P152F 152 P F 0.878 Pathogenic PMS2 P54278 P152G 152 P G 0.06 Neutral PMS2 P54278 P152H 152 P H 0.8 Pathogenic PMS2 P54278 P152I 152 P I 0.646 Pathogenic PMS2 P54278 P152K 152 P K 0.322 Neutral PMS2 P54278 P152L 152 P L 0.608 Pathogenic PMS2 P54278 P152M 152 P M 0.684 Pathogenic PMS2 P54278 P152N 152 P N 0.16 Neutral PMS2 P54278 P152Q 152 P Q 0.19 Neutral PMS2 P54278 P152R 152 P R 0.586 Pathogenic PMS2 P54278 P152S 152 P S 0.042 Neutral PMS2 P54278 P152T 152 P T 0.578 Pathogenic PMS2 P54278 P152V 152 P V 0.56 Pathogenic PMS2 P54278 P152W 152 P W 0.866 Pathogenic PMS2 P54278 P152Y 152 P Y 0.846 Pathogenic PMS2 P54278 R153A 153 R A 0.184 Neutral PMS2 P54278 R153C 153 R C 0.244 Neutral PMS2 P54278 R153D 153 R D 0.264 Neutral PMS2 P54278 R153E 153 R E 0.204 Neutral PMS2 P54278 R153F 153 R F 0.47 Neutral PMS2 P54278 R153G 153 R G 0.156 Neutral PMS2 P54278 R153H 153 R H 0.252 Neutral PMS2 P54278 R153I 153 R I 0.116 Neutral PMS2 P54278 R153K 153 R K 0.008 Neutral PMS2 P54278 R153L 153 R L 0.432 Neutral PMS2 P54278 R153M 153 R M 0.258 Neutral PMS2 P54278 R153N 153 R N 0.262 Neutral PMS2 P54278 R153P 153 R P 0.122 Neutral PMS2 P54278 R153Q 153 R Q 0.01 Neutral PMS2 P54278 R153S 153 R S 0.09 Neutral PMS2 P54278 R153T 153 R T 0.022 Neutral PMS2 P54278 R153V 153 R V 0.052 Neutral PMS2 P54278 R153W 153 R W 0.622 Pathogenic PMS2 P54278 R153Y 153 R Y 0.464 Neutral PMS2 P54278 G154A 154 G A 0.88 Pathogenic PMS2 P54278 G154C 154 G C 0.918 Pathogenic PMS2 P54278 G154D 154 G D 0.956 Pathogenic PMS2 P54278 G154E 154 G E 0.978 Pathogenic PMS2 P54278 G154F 154 G F 0.982 Pathogenic PMS2 P54278 G154H 154 G H 0.98 Pathogenic PMS2 P54278 G154I 154 G I 0.972 Pathogenic PMS2 P54278 G154K 154 G K 0.982 Pathogenic PMS2 P54278 G154L 154 G L 0.982 Pathogenic PMS2 P54278 G154M 154 G M 0.988 Pathogenic PMS2 P54278 G154N 154 G N 0.916 Pathogenic PMS2 P54278 G154P 154 G P 0.968 Pathogenic PMS2 P54278 G154Q 154 G Q 0.96 Pathogenic PMS2 P54278 G154R 154 G R 0.996 Pathogenic PMS2 P54278 G154S 154 G S 0.626 Pathogenic PMS2 P54278 G154T 154 G T 0.812 Pathogenic PMS2 P54278 G154V 154 G V 0.982 Pathogenic PMS2 P54278 G154W 154 G W 0.972 Pathogenic PMS2 P54278 G154Y 154 G Y 0.972 Pathogenic PMS2 P54278 T155A 155 T A 0.58 Pathogenic PMS2 P54278 T155C 155 T C 0.798 Pathogenic PMS2 P54278 T155D 155 T D 0.812 Pathogenic PMS2 P54278 T155E 155 T E 0.884 Pathogenic PMS2 P54278 T155F 155 T F 0.902 Pathogenic PMS2 P54278 T155G 155 T G 0.566 Pathogenic PMS2 P54278 T155H 155 T H 0.828 Pathogenic PMS2 P54278 T155I 155 T I 0.858 Pathogenic PMS2 P54278 T155K 155 T K 0.838 Pathogenic PMS2 P54278 T155L 155 T L 0.844 Pathogenic PMS2 P54278 T155M 155 T M 0.486 Neutral PMS2 P54278 T155N 155 T N 0.728 Pathogenic PMS2 P54278 T155P 155 T P 0.888 Pathogenic PMS2 P54278 T155Q 155 T Q 0.738 Pathogenic PMS2 P54278 T155R 155 T R 0.95 Pathogenic PMS2 P54278 T155S 155 T S 0.204 Neutral PMS2 P54278 T155V 155 T V 0.81 Pathogenic PMS2 P54278 T155W 155 T W 0.964 Pathogenic PMS2 P54278 T155Y 155 T Y 0.964 Pathogenic PMS2 P54278 T156A 156 T A 0.076 Neutral PMS2 P54278 T156C 156 T C 0.588 Pathogenic PMS2 P54278 T156D 156 T D 0.598 Pathogenic PMS2 P54278 T156E 156 T E 0.682 Pathogenic PMS2 P54278 T156F 156 T F 0.782 Pathogenic PMS2 P54278 T156G 156 T G 0.096 Neutral PMS2 P54278 T156H 156 T H 0.648 Pathogenic PMS2 P54278 T156I 156 T I 0.456 Neutral PMS2 P54278 T156K 156 T K 0.626 Pathogenic PMS2 P54278 T156L 156 T L 0.426 Neutral PMS2 P54278 T156M 156 T M 0.36 Neutral PMS2 P54278 T156N 156 T N 0.432 Neutral PMS2 P54278 T156P 156 T P 0.686 Pathogenic PMS2 P54278 T156Q 156 T Q 0.456 Neutral PMS2 P54278 T156R 156 T R 0.86 Pathogenic PMS2 P54278 T156S 156 T S 0.02 Neutral PMS2 P54278 T156V 156 T V 0.644 Pathogenic PMS2 P54278 T156W 156 T W 0.912 Pathogenic PMS2 P54278 T156Y 156 T Y 0.908 Pathogenic PMS2 P54278 V157A 157 V A 0.024 Neutral PMS2 P54278 V157C 157 V C 0.412 Neutral PMS2 P54278 V157D 157 V D 0.6 Pathogenic PMS2 P54278 V157E 157 V E 0.702 Pathogenic PMS2 P54278 V157F 157 V F 0.764 Pathogenic PMS2 P54278 V157G 157 V G 0.614 Pathogenic PMS2 P54278 V157H 157 V H 0.56 Pathogenic PMS2 P54278 V157I 157 V I 0.084 Neutral PMS2 P54278 V157K 157 V K 0.768 Pathogenic PMS2 P54278 V157L 157 V L 0.348 Neutral PMS2 P54278 V157M 157 V M 0.52 Pathogenic PMS2 P54278 V157N 157 V N 0.644 Pathogenic PMS2 P54278 V157P 157 V P 0.822 Pathogenic PMS2 P54278 V157Q 157 V Q 0.722 Pathogenic PMS2 P54278 V157R 157 V R 0.824 Pathogenic PMS2 P54278 V157S 157 V S 0.462 Neutral PMS2 P54278 V157T 157 V T 0.084 Neutral PMS2 P54278 V157W 157 V W 0.84 Pathogenic PMS2 P54278 V157Y 157 V Y 0.832 Pathogenic PMS2 P54278 S158A 158 S A 0.04 Neutral PMS2 P54278 S158C 158 S C 0.292 Neutral PMS2 P54278 S158D 158 S D 0.338 Neutral PMS2 P54278 S158E 158 S E 0.568 Pathogenic PMS2 P54278 S158F 158 S F 0.588 Pathogenic PMS2 P54278 S158G 158 S G 0.262 Neutral PMS2 P54278 S158H 158 S H 0.392 Neutral PMS2 P54278 S158I 158 S I 0.27 Neutral PMS2 P54278 S158K 158 S K 0.6 Pathogenic PMS2 P54278 S158L 158 S L 0.104 Neutral PMS2 P54278 S158M 158 S M 0.536 Pathogenic PMS2 P54278 S158N 158 S N 0.042 Neutral PMS2 P54278 S158P 158 S P 0.446 Neutral PMS2 P54278 S158Q 158 S Q 0.458 Neutral PMS2 P54278 S158R 158 S R 0.48 Neutral PMS2 P54278 S158T 158 S T 0.054 Neutral PMS2 P54278 S158V 158 S V 0.188 Neutral PMS2 P54278 S158W 158 S W 0.892 Pathogenic PMS2 P54278 S158Y 158 S Y 0.87 Pathogenic PMS2 P54278 V159A 159 V A 0.13 Neutral PMS2 P54278 V159C 159 V C 0.172 Neutral PMS2 P54278 V159D 159 V D 0.862 Pathogenic PMS2 P54278 V159E 159 V E 0.974 Pathogenic PMS2 P54278 V159F 159 V F 0.86 Pathogenic PMS2 P54278 V159G 159 V G 0.482 Neutral PMS2 P54278 V159H 159 V H 0.792 Pathogenic PMS2 P54278 V159I 159 V I 0.152 Neutral PMS2 P54278 V159K 159 V K 0.96 Pathogenic PMS2 P54278 V159L 159 V L 0.194 Neutral PMS2 P54278 V159M 159 V M 0.24 Neutral PMS2 P54278 V159N 159 V N 0.93 Pathogenic PMS2 P54278 V159P 159 V P 0.342 Neutral PMS2 P54278 V159Q 159 V Q 0.988 Pathogenic PMS2 P54278 V159R 159 V R 0.956 Pathogenic PMS2 P54278 V159S 159 V S 0.154 Neutral PMS2 P54278 V159T 159 V T 0.726 Pathogenic PMS2 P54278 V159W 159 V W 0.898 Pathogenic PMS2 P54278 V159Y 159 V Y 0.92 Pathogenic PMS2 P54278 K16A 16 K A 0.072 Neutral PMS2 P54278 K16C 16 K C 0.17 Neutral PMS2 P54278 K16D 16 K D 0.052 Neutral PMS2 P54278 K16E 16 K E 0.018 Neutral PMS2 P54278 K16F 16 K F 0.776 Pathogenic PMS2 P54278 K16G 16 K G 0.278 Neutral PMS2 P54278 K16H 16 K H 0.01 Neutral PMS2 P54278 K16I 16 K I 0.818 Pathogenic PMS2 P54278 K16L 16 K L 0.096 Neutral PMS2 P54278 K16M 16 K M 0.592 Pathogenic PMS2 P54278 K16N 16 K N 0.03 Neutral PMS2 P54278 K16P 16 K P 0.798 Pathogenic PMS2 P54278 K16Q 16 K Q 0.028 Neutral PMS2 P54278 K16R 16 K R 0.02 Neutral PMS2 P54278 K16S 16 K S 0.034 Neutral PMS2 P54278 K16T 16 K T 0.03 Neutral PMS2 P54278 K16V 16 K V 0.718 Pathogenic PMS2 P54278 K16W 16 K W 0.95 Pathogenic PMS2 P54278 K16Y 16 K Y 0.384 Neutral PMS2 P54278 Q160A 160 Q A 0.154 Neutral PMS2 P54278 Q160C 160 Q C 0.328 Neutral PMS2 P54278 Q160D 160 Q D 0.128 Neutral PMS2 P54278 Q160E 160 Q E 0.034 Neutral PMS2 P54278 Q160F 160 Q F 0.808 Pathogenic PMS2 P54278 Q160G 160 Q G 0.348 Neutral PMS2 P54278 Q160H 160 Q H 0.816 Pathogenic PMS2 P54278 Q160I 160 Q I 0.342 Neutral PMS2 P54278 Q160K 160 Q K 0.064 Neutral PMS2 P54278 Q160L 160 Q L 0.196 Neutral PMS2 P54278 Q160M 160 Q M 0.388 Neutral PMS2 P54278 Q160N 160 Q N 0.112 Neutral PMS2 P54278 Q160P 160 Q P 0.84 Pathogenic PMS2 P54278 Q160R 160 Q R 0.082 Neutral PMS2 P54278 Q160S 160 Q S 0.102 Neutral PMS2 P54278 Q160T 160 Q T 0.04 Neutral PMS2 P54278 Q160V 160 Q V 0.746 Pathogenic PMS2 P54278 Q160W 160 Q W 0.93 Pathogenic PMS2 P54278 Q160Y 160 Q Y 0.89 Pathogenic PMS2 P54278 Q161A 161 Q A 0.146 Neutral PMS2 P54278 Q161C 161 Q C 0.366 Neutral PMS2 P54278 Q161D 161 Q D 0.31 Neutral PMS2 P54278 Q161E 161 Q E 0.06 Neutral PMS2 P54278 Q161F 161 Q F 0.854 Pathogenic PMS2 P54278 Q161G 161 Q G 0.098 Neutral PMS2 P54278 Q161H 161 Q H 0.086 Neutral PMS2 P54278 Q161I 161 Q I 0.572 Pathogenic PMS2 P54278 Q161K 161 Q K 0.052 Neutral PMS2 P54278 Q161L 161 Q L 0.2 Neutral PMS2 P54278 Q161M 161 Q M 0.68 Pathogenic PMS2 P54278 Q161N 161 Q N 0.082 Neutral PMS2 P54278 Q161P 161 Q P 0.318 Neutral PMS2 P54278 Q161R 161 Q R 0.056 Neutral PMS2 P54278 Q161S 161 Q S 0.086 Neutral PMS2 P54278 Q161T 161 Q T 0.026 Neutral PMS2 P54278 Q161V 161 Q V 0.808 Pathogenic PMS2 P54278 Q161W 161 Q W 0.898 Pathogenic PMS2 P54278 Q161Y 161 Q Y 0.656 Pathogenic PMS2 P54278 L162A 162 L A 0.714 Pathogenic PMS2 P54278 L162C 162 L C 0.816 Pathogenic PMS2 P54278 L162D 162 L D 0.9 Pathogenic PMS2 P54278 L162E 162 L E 0.882 Pathogenic PMS2 P54278 L162F 162 L F 0.676 Pathogenic PMS2 P54278 L162G 162 L G 0.87 Pathogenic PMS2 P54278 L162H 162 L H 0.906 Pathogenic PMS2 P54278 L162I 162 L I 0.258 Neutral PMS2 P54278 L162K 162 L K 0.71 Pathogenic PMS2 P54278 L162M 162 L M 0.198 Neutral PMS2 P54278 L162N 162 L N 0.528 Pathogenic PMS2 P54278 L162P 162 L P 0.704 Pathogenic PMS2 P54278 L162Q 162 L Q 0.764 Pathogenic PMS2 P54278 L162R 162 L R 0.982 Pathogenic PMS2 P54278 L162S 162 L S 0.698 Pathogenic PMS2 P54278 L162T 162 L T 0.614 Pathogenic PMS2 P54278 L162V 162 L V 0.122 Neutral PMS2 P54278 L162W 162 L W 0.862 Pathogenic PMS2 P54278 L162Y 162 L Y 0.878 Pathogenic PMS2 P54278 F163A 163 F A 0.42 Neutral PMS2 P54278 F163C 163 F C 0.588 Pathogenic PMS2 P54278 F163D 163 F D 0.144 Neutral PMS2 P54278 F163E 163 F E 0.156 Neutral PMS2 P54278 F163G 163 F G 0.298 Neutral PMS2 P54278 F163H 163 F H 0.098 Neutral PMS2 P54278 F163I 163 F I 0.564 Pathogenic PMS2 P54278 F163K 163 F K 0.482 Neutral PMS2 P54278 F163L 163 F L 0.146 Neutral PMS2 P54278 F163M 163 F M 0.674 Pathogenic PMS2 P54278 F163N 163 F N 0.15 Neutral PMS2 P54278 F163P 163 F P 0.324 Neutral PMS2 P54278 F163Q 163 F Q 0.176 Neutral PMS2 P54278 F163R 163 F R 0.538 Pathogenic PMS2 P54278 F163S 163 F S 0.17 Neutral PMS2 P54278 F163T 163 F T 0.356 Neutral PMS2 P54278 F163V 163 F V 0.822 Pathogenic PMS2 P54278 F163W 163 F W 0.932 Pathogenic PMS2 P54278 F163Y 163 F Y 0.7 Pathogenic PMS2 P54278 S164A 164 S A 0.01 Neutral PMS2 P54278 S164C 164 S C 0.002 Neutral PMS2 P54278 S164D 164 S D 0.1 Neutral PMS2 P54278 S164E 164 S E 0.252 Neutral PMS2 P54278 S164F 164 S F 0.524 Pathogenic PMS2 P54278 S164G 164 S G 0.118 Neutral PMS2 P54278 S164H 164 S H 0.29 Neutral PMS2 P54278 S164I 164 S I 0.184 Neutral PMS2 P54278 S164K 164 S K 0.268 Neutral PMS2 P54278 S164L 164 S L 0.184 Neutral PMS2 P54278 S164M 164 S M 0.648 Pathogenic PMS2 P54278 S164N 164 S N 0.006 Neutral PMS2 P54278 S164P 164 S P 0.224 Neutral PMS2 P54278 S164Q 164 S Q 0.3 Neutral PMS2 P54278 S164R 164 S R 0.318 Neutral PMS2 P54278 S164T 164 S T 0.302 Neutral PMS2 P54278 S164V 164 S V 0.056 Neutral PMS2 P54278 S164W 164 S W 0.772 Pathogenic PMS2 P54278 S164Y 164 S Y 0.522 Pathogenic PMS2 P54278 T165A 165 T A 0.27 Neutral PMS2 P54278 T165C 165 T C 0.238 Neutral PMS2 P54278 T165D 165 T D 0.388 Neutral PMS2 P54278 T165E 165 T E 0.7 Pathogenic PMS2 P54278 T165F 165 T F 0.49 Neutral PMS2 P54278 T165G 165 T G 0.124 Neutral PMS2 P54278 T165H 165 T H 0.65 Pathogenic PMS2 P54278 T165I 165 T I 0.322 Neutral PMS2 P54278 T165K 165 T K 0.126 Neutral PMS2 P54278 T165L 165 T L 0.11 Neutral PMS2 P54278 T165M 165 T M 0.54 Pathogenic PMS2 P54278 T165N 165 T N 0.018 Neutral PMS2 P54278 T165P 165 T P 0.078 Neutral PMS2 P54278 T165Q 165 T Q 0.444 Neutral PMS2 P54278 T165R 165 T R 0.476 Neutral PMS2 P54278 T165S 165 T S 0.012 Neutral PMS2 P54278 T165V 165 T V 0.328 Neutral PMS2 P54278 T165W 165 T W 0.932 Pathogenic PMS2 P54278 T165Y 165 T Y 0.928 Pathogenic PMS2 P54278 L166A 166 L A 0.162 Neutral PMS2 P54278 L166C 166 L C 0.692 Pathogenic PMS2 P54278 L166D 166 L D 0.886 Pathogenic PMS2 P54278 L166E 166 L E 0.51 Pathogenic PMS2 P54278 L166F 166 L F 0.976 Pathogenic PMS2 P54278 L166G 166 L G 0.28 Neutral PMS2 P54278 L166H 166 L H 0.822 Pathogenic PMS2 P54278 L166I 166 L I 0.45 Neutral PMS2 P54278 L166K 166 L K 0.742 Pathogenic PMS2 P54278 L166M 166 L M 0.268 Neutral PMS2 P54278 L166N 166 L N 0.752 Pathogenic PMS2 P54278 L166P 166 L P 0.324 Neutral PMS2 P54278 L166Q 166 L Q 0.624 Pathogenic PMS2 P54278 L166R 166 L R 0.99 Pathogenic PMS2 P54278 L166S 166 L S 0.13 Neutral PMS2 P54278 L166T 166 L T 0.118 Neutral PMS2 P54278 L166V 166 L V 0.546 Pathogenic PMS2 P54278 L166W 166 L W 0.94 Pathogenic PMS2 P54278 L166Y 166 L Y 0.906 Pathogenic PMS2 P54278 P167A 167 P A 0.19 Neutral PMS2 P54278 P167C 167 P C 0.518 Pathogenic PMS2 P54278 P167D 167 P D 0.858 Pathogenic PMS2 P54278 P167E 167 P E 0.954 Pathogenic PMS2 P54278 P167F 167 P F 0.998 Pathogenic PMS2 P54278 P167G 167 P G 0.2 Neutral PMS2 P54278 P167H 167 P H 0.976 Pathogenic PMS2 P54278 P167I 167 P I 0.934 Pathogenic PMS2 P54278 P167K 167 P K 0.946 Pathogenic PMS2 P54278 P167L 167 P L 0.686 Pathogenic PMS2 P54278 P167M 167 P M 0.956 Pathogenic PMS2 P54278 P167N 167 P N 0.752 Pathogenic PMS2 P54278 P167Q 167 P Q 0.844 Pathogenic PMS2 P54278 P167R 167 P R 0.978 Pathogenic PMS2 P54278 P167S 167 P S 0.074 Neutral PMS2 P54278 P167T 167 P T 0.704 Pathogenic PMS2 P54278 P167V 167 P V 0.178 Neutral PMS2 P54278 P167W 167 P W 0.934 Pathogenic PMS2 P54278 P167Y 167 P Y 0.93 Pathogenic PMS2 P54278 V168A 168 V A 0.112 Neutral PMS2 P54278 V168C 168 V C 0.782 Pathogenic PMS2 P54278 V168D 168 V D 0.226 Neutral PMS2 P54278 V168E 168 V E 0.244 Neutral PMS2 P54278 V168F 168 V F 0.91 Pathogenic PMS2 P54278 V168G 168 V G 0.268 Neutral PMS2 P54278 V168H 168 V H 0.878 Pathogenic PMS2 P54278 V168I 168 V I 0.258 Neutral PMS2 P54278 V168K 168 V K 0.988 Pathogenic PMS2 P54278 V168L 168 V L 0.254 Neutral PMS2 P54278 V168M 168 V M 0.344 Neutral PMS2 P54278 V168N 168 V N 0.916 Pathogenic PMS2 P54278 V168P 168 V P 0.986 Pathogenic PMS2 P54278 V168Q 168 V Q 0.972 Pathogenic PMS2 P54278 V168R 168 V R 0.948 Pathogenic PMS2 P54278 V168S 168 V S 0.186 Neutral PMS2 P54278 V168T 168 V T 0.374 Neutral PMS2 P54278 V168W 168 V W 0.934 Pathogenic PMS2 P54278 V168Y 168 V Y 0.96 Pathogenic PMS2 P54278 R169A 169 R A 0.262 Neutral PMS2 P54278 R169C 169 R C 0.946 Pathogenic PMS2 P54278 R169D 169 R D 0.2 Neutral PMS2 P54278 R169E 169 R E 0.188 Neutral PMS2 P54278 R169F 169 R F 0.972 Pathogenic PMS2 P54278 R169G 169 R G 0.088 Neutral PMS2 P54278 R169H 169 R H 0.178 Neutral PMS2 P54278 R169I 169 R I 0.974 Pathogenic PMS2 P54278 R169K 169 R K 0.604 Pathogenic PMS2 P54278 R169L 169 R L 0.984 Pathogenic PMS2 P54278 R169M 169 R M 0.8 Pathogenic PMS2 P54278 R169N 169 R N 0.14 Neutral PMS2 P54278 R169P 169 R P 0.984 Pathogenic PMS2 P54278 R169Q 169 R Q 0.184 Neutral PMS2 P54278 R169S 169 R S 0.172 Neutral PMS2 P54278 R169T 169 R T 0.916 Pathogenic PMS2 P54278 R169V 169 R V 0.972 Pathogenic PMS2 P54278 R169W 169 R W 0.97 Pathogenic PMS2 P54278 R169Y 169 R Y 0.972 Pathogenic PMS2 P54278 P17A 17 P A 0.096 Neutral PMS2 P54278 P17C 17 P C 0.516 Pathogenic PMS2 P54278 P17D 17 P D 0.064 Neutral PMS2 P54278 P17E 17 P E 0.152 Neutral PMS2 P54278 P17F 17 P F 0.916 Pathogenic PMS2 P54278 P17G 17 P G 0.272 Neutral PMS2 P54278 P17H 17 P H 0.646 Pathogenic PMS2 P54278 P17I 17 P I 0.476 Neutral PMS2 P54278 P17K 17 P K 0.144 Neutral PMS2 P54278 P17L 17 P L 0.64 Pathogenic PMS2 P54278 P17M 17 P M 0.68 Pathogenic PMS2 P54278 P17N 17 P N 0.166 Neutral PMS2 P54278 P17Q 17 P Q 0.148 Neutral PMS2 P54278 P17R 17 P R 0.528 Pathogenic PMS2 P54278 P17S 17 P S 0.046 Neutral PMS2 P54278 P17T 17 P T 0.284 Neutral PMS2 P54278 P17V 17 P V 0.112 Neutral PMS2 P54278 P17W 17 P W 0.894 Pathogenic PMS2 P54278 P17Y 17 P Y 0.874 Pathogenic PMS2 P54278 H170A 170 H A 0.112 Neutral PMS2 P54278 H170C 170 H C 0.044 Neutral PMS2 P54278 H170D 170 H D 0.258 Neutral PMS2 P54278 H170E 170 H E 0.06 Neutral PMS2 P54278 H170F 170 H F 0.382 Neutral PMS2 P54278 H170G 170 H G 0.098 Neutral PMS2 P54278 H170I 170 H I 0.78 Pathogenic PMS2 P54278 H170K 170 H K 0.026 Neutral PMS2 P54278 H170L 170 H L 0.636 Pathogenic PMS2 P54278 H170M 170 H M 0.624 Pathogenic PMS2 P54278 H170N 170 H N 0.104 Neutral PMS2 P54278 H170P 170 H P 0.906 Pathogenic PMS2 P54278 H170Q 170 H Q 0.022 Neutral PMS2 P54278 H170R 170 H R 0.02 Neutral PMS2 P54278 H170S 170 H S 0.03 Neutral PMS2 P54278 H170T 170 H T 0.46 Neutral PMS2 P54278 H170V 170 H V 0.534 Pathogenic PMS2 P54278 H170W 170 H W 0.954 Pathogenic PMS2 P54278 H170Y 170 H Y 0.116 Neutral PMS2 P54278 K171A 171 K A 0.078 Neutral PMS2 P54278 K171C 171 K C 0.198 Neutral PMS2 P54278 K171D 171 K D 0.312 Neutral PMS2 P54278 K171E 171 K E 0.024 Neutral PMS2 P54278 K171F 171 K F 0.846 Pathogenic PMS2 P54278 K171G 171 K G 0.302 Neutral PMS2 P54278 K171H 171 K H 0.15 Neutral PMS2 P54278 K171I 171 K I 0.11 Neutral PMS2 P54278 K171L 171 K L 0.396 Neutral PMS2 P54278 K171M 171 K M 0.066 Neutral PMS2 P54278 K171N 171 K N 0.04 Neutral PMS2 P54278 K171P 171 K P 0.832 Pathogenic PMS2 P54278 K171Q 171 K Q 0.046 Neutral PMS2 P54278 K171R 171 K R 0.038 Neutral PMS2 P54278 K171S 171 K S 0.028 Neutral PMS2 P54278 K171T 171 K T 0.042 Neutral PMS2 P54278 K171V 171 K V 0.098 Neutral PMS2 P54278 K171W 171 K W 0.98 Pathogenic PMS2 P54278 K171Y 171 K Y 0.932 Pathogenic PMS2 P54278 E172A 172 E A 0.41 Neutral PMS2 P54278 E172C 172 E C 0.648 Pathogenic PMS2 P54278 E172D 172 E D 0.112 Neutral PMS2 P54278 E172F 172 E F 0.958 Pathogenic PMS2 P54278 E172G 172 E G 0.378 Neutral PMS2 P54278 E172H 172 E H 0.846 Pathogenic PMS2 P54278 E172I 172 E I 0.396 Neutral PMS2 P54278 E172K 172 E K 0.964 Pathogenic PMS2 P54278 E172L 172 E L 0.404 Neutral PMS2 P54278 E172M 172 E M 0.9 Pathogenic PMS2 P54278 E172N 172 E N 0.214 Neutral PMS2 P54278 E172P 172 E P 0.93 Pathogenic PMS2 P54278 E172Q 172 E Q 0.224 Neutral PMS2 P54278 E172R 172 E R 0.522 Pathogenic PMS2 P54278 E172S 172 E S 0.856 Pathogenic PMS2 P54278 E172T 172 E T 0.17 Neutral PMS2 P54278 E172V 172 E V 0.306 Neutral PMS2 P54278 E172W 172 E W 0.986 Pathogenic PMS2 P54278 E172Y 172 E Y 0.966 Pathogenic PMS2 P54278 F173A 173 F A 0.138 Neutral PMS2 P54278 F173C 173 F C 0.58 Pathogenic PMS2 P54278 F173D 173 F D 0.792 Pathogenic PMS2 P54278 F173E 173 F E 0.872 Pathogenic PMS2 P54278 F173G 173 F G 0.486 Neutral PMS2 P54278 F173H 173 F H 0.638 Pathogenic PMS2 P54278 F173I 173 F I 0.108 Neutral PMS2 P54278 F173K 173 F K 0.854 Pathogenic PMS2 P54278 F173L 173 F L 0.09 Neutral PMS2 P54278 F173M 173 F M 0.264 Neutral PMS2 P54278 F173N 173 F N 0.432 Neutral PMS2 P54278 F173P 173 F P 0.944 Pathogenic PMS2 P54278 F173Q 173 F Q 0.744 Pathogenic PMS2 P54278 F173R 173 F R 0.92 Pathogenic PMS2 P54278 F173S 173 F S 0.76 Pathogenic PMS2 P54278 F173T 173 F T 0.586 Pathogenic PMS2 P54278 F173V 173 F V 0.166 Neutral PMS2 P54278 F173W 173 F W 0.938 Pathogenic PMS2 P54278 F173Y 173 F Y 0.584 Pathogenic PMS2 P54278 Q174A 174 Q A 0.492 Neutral PMS2 P54278 Q174C 174 Q C 0.44 Neutral PMS2 P54278 Q174D 174 Q D 0.452 Neutral PMS2 P54278 Q174E 174 Q E 0.042 Neutral PMS2 P54278 Q174F 174 Q F 0.85 Pathogenic PMS2 P54278 Q174G 174 Q G 0.432 Neutral PMS2 P54278 Q174H 174 Q H 0.088 Neutral PMS2 P54278 Q174I 174 Q I 0.33 Neutral PMS2 P54278 Q174K 174 Q K 0.07 Neutral PMS2 P54278 Q174L 174 Q L 0.196 Neutral PMS2 P54278 Q174M 174 Q M 0.072 Neutral PMS2 P54278 Q174N 174 Q N 0.416 Neutral PMS2 P54278 Q174P 174 Q P 0.838 Pathogenic PMS2 P54278 Q174R 174 Q R 0.09 Neutral PMS2 P54278 Q174S 174 Q S 0.1 Neutral PMS2 P54278 Q174T 174 Q T 0.046 Neutral PMS2 P54278 Q174V 174 Q V 0.14 Neutral PMS2 P54278 Q174W 174 Q W 0.9 Pathogenic PMS2 P54278 Q174Y 174 Q Y 0.856 Pathogenic PMS2 P54278 R175A 175 R A 0.332 Neutral PMS2 P54278 R175C 175 R C 0.636 Pathogenic PMS2 P54278 R175D 175 R D 0.042 Neutral PMS2 P54278 R175E 175 R E 0.06 Neutral PMS2 P54278 R175F 175 R F 0.774 Pathogenic PMS2 P54278 R175G 175 R G 0.204 Neutral PMS2 P54278 R175H 175 R H 0.446 Neutral PMS2 P54278 R175I 175 R I 0.19 Neutral PMS2 P54278 R175K 175 R K 0.042 Neutral PMS2 P54278 R175L 175 R L 0.856 Pathogenic PMS2 P54278 R175M 175 R M 0.058 Neutral PMS2 P54278 R175N 175 R N 0.022 Neutral PMS2 P54278 R175P 175 R P 0.826 Pathogenic PMS2 P54278 R175Q 175 R Q 0.016 Neutral PMS2 P54278 R175S 175 R S 0.304 Neutral PMS2 P54278 R175T 175 R T 0.164 Neutral PMS2 P54278 R175V 175 R V 0.804 Pathogenic PMS2 P54278 R175W 175 R W 0.892 Pathogenic PMS2 P54278 R175Y 175 R Y 0.868 Pathogenic PMS2 P54278 N176A 176 N A 0.78 Pathogenic PMS2 P54278 N176C 176 N C 0.73 Pathogenic PMS2 P54278 N176D 176 N D 0.45 Neutral PMS2 P54278 N176E 176 N E 0.486 Neutral PMS2 P54278 N176F 176 N F 0.946 Pathogenic PMS2 P54278 N176G 176 N G 0.678 Pathogenic PMS2 P54278 N176H 176 N H 0.358 Neutral PMS2 P54278 N176I 176 N I 0.932 Pathogenic PMS2 P54278 N176K 176 N K 0.88 Pathogenic PMS2 P54278 N176L 176 N L 0.94 Pathogenic PMS2 P54278 N176M 176 N M 0.942 Pathogenic PMS2 P54278 N176P 176 N P 0.834 Pathogenic PMS2 P54278 N176Q 176 N Q 0.73 Pathogenic PMS2 P54278 N176R 176 N R 0.942 Pathogenic PMS2 P54278 N176S 176 N S 0.146 Neutral PMS2 P54278 N176T 176 N T 0.35 Neutral PMS2 P54278 N176V 176 N V 0.974 Pathogenic PMS2 P54278 N176W 176 N W 0.962 Pathogenic PMS2 P54278 N176Y 176 N Y 0.834 Pathogenic PMS2 P54278 I177A 177 I A 0.054 Neutral PMS2 P54278 I177C 177 I C 0.3 Neutral PMS2 P54278 I177D 177 I D 0.576 Pathogenic PMS2 P54278 I177E 177 I E 0.56 Pathogenic PMS2 P54278 I177F 177 I F 0.69 Pathogenic PMS2 P54278 I177G 177 I G 0.556 Pathogenic PMS2 P54278 I177H 177 I H 0.434 Neutral PMS2 P54278 I177K 177 I K 0.256 Neutral PMS2 P54278 I177L 177 I L 0.006 Neutral PMS2 P54278 I177M 177 I M 0.384 Neutral PMS2 P54278 I177N 177 I N 0.62 Pathogenic PMS2 P54278 I177P 177 I P 0.714 Pathogenic PMS2 P54278 I177Q 177 I Q 0.566 Pathogenic PMS2 P54278 I177R 177 I R 0.822 Pathogenic PMS2 P54278 I177S 177 I S 0.278 Neutral PMS2 P54278 I177T 177 I T 0.422 Neutral PMS2 P54278 I177V 177 I V 0.012 Neutral PMS2 P54278 I177W 177 I W 0.894 Pathogenic PMS2 P54278 I177Y 177 I Y 0.9 Pathogenic PMS2 P54278 K178A 178 K A 0.27 Neutral PMS2 P54278 K178C 178 K C 0.22 Neutral PMS2 P54278 K178D 178 K D 0.344 Neutral PMS2 P54278 K178E 178 K E 0.4 Neutral PMS2 P54278 K178F 178 K F 0.776 Pathogenic PMS2 P54278 K178G 178 K G 0.366 Neutral PMS2 P54278 K178H 178 K H 0.424 Neutral PMS2 P54278 K178I 178 K I 0.738 Pathogenic PMS2 P54278 K178L 178 K L 0.674 Pathogenic PMS2 P54278 K178M 178 K M 0.652 Pathogenic PMS2 P54278 K178N 178 K N 0.386 Neutral PMS2 P54278 K178P 178 K P 0.826 Pathogenic PMS2 P54278 K178Q 178 K Q 0.428 Neutral PMS2 P54278 K178R 178 K R 0.036 Neutral PMS2 P54278 K178S 178 K S 0.432 Neutral PMS2 P54278 K178T 178 K T 0.3 Neutral PMS2 P54278 K178V 178 K V 0.772 Pathogenic PMS2 P54278 K178W 178 K W 0.97 Pathogenic PMS2 P54278 K178Y 178 K Y 0.93 Pathogenic PMS2 P54278 K179A 179 K A 0.254 Neutral PMS2 P54278 K179C 179 K C 0.206 Neutral PMS2 P54278 K179D 179 K D 0.322 Neutral PMS2 P54278 K179E 179 K E 0.154 Neutral PMS2 P54278 K179F 179 K F 0.844 Pathogenic PMS2 P54278 K179G 179 K G 0.36 Neutral PMS2 P54278 K179H 179 K H 0.406 Neutral PMS2 P54278 K179I 179 K I 0.894 Pathogenic PMS2 P54278 K179L 179 K L 0.86 Pathogenic PMS2 P54278 K179M 179 K M 0.654 Pathogenic PMS2 P54278 K179N 179 K N 0.364 Neutral PMS2 P54278 K179P 179 K P 0.832 Pathogenic PMS2 P54278 K179Q 179 K Q 0.166 Neutral PMS2 P54278 K179R 179 K R 0.036 Neutral PMS2 P54278 K179S 179 K S 0.44 Neutral PMS2 P54278 K179T 179 K T 0.28 Neutral PMS2 P54278 K179V 179 K V 0.78 Pathogenic PMS2 P54278 K179W 179 K W 0.972 Pathogenic PMS2 P54278 K179Y 179 K Y 0.926 Pathogenic PMS2 P54278 I18A 18 I A 0.462 Neutral PMS2 P54278 I18C 18 I C 0.604 Pathogenic PMS2 P54278 I18D 18 I D 0.774 Pathogenic PMS2 P54278 I18E 18 I E 0.77 Pathogenic PMS2 P54278 I18F 18 I F 0.79 Pathogenic PMS2 P54278 I18G 18 I G 0.81 Pathogenic PMS2 P54278 I18H 18 I H 0.774 Pathogenic PMS2 P54278 I18K 18 I K 0.81 Pathogenic PMS2 P54278 I18L 18 I L 0.102 Neutral PMS2 P54278 I18M 18 I M 0.544 Pathogenic PMS2 P54278 I18N 18 I N 0.802 Pathogenic PMS2 P54278 I18P 18 I P 0.866 Pathogenic PMS2 P54278 I18Q 18 I Q 0.296 Neutral PMS2 P54278 I18R 18 I R 0.88 Pathogenic PMS2 P54278 I18S 18 I S 0.56 Pathogenic PMS2 P54278 I18T 18 I T 0.35 Neutral PMS2 P54278 I18V 18 I V 0.37 Neutral 2 PMS2 P54278 I18W 18 I W 0.84 Pathogenic PMS2 P54278 I18Y 18 I Y 0.836 Pathogenic PMS2 P54278 E180A 180 E A 0.518 Pathogenic PMS2 P54278 E180C 180 E C 0.494 Neutral PMS2 P54278 E180D 180 E D 0.088 Neutral PMS2 P54278 E180F 180 E F 0.888 Pathogenic PMS2 P54278 E180G 180 E G 0.152 Neutral PMS2 P54278 E180H 180 E H 0.608 Pathogenic PMS2 P54278 E180I 180 E I 0.942 Pathogenic PMS2 P54278 E180K 180 E K 0.054 Neutral PMS2 P54278 E180L 180 E L 0.906 Pathogenic PMS2 P54278 E180M 180 E M 0.714 Pathogenic PMS2 P54278 E180N 180 E N 0.36 Neutral PMS2 P54278 E180P 180 E P 0.888 Pathogenic PMS2 P54278 E180Q 180 E Q 0.06 Neutral PMS2 P54278 E180R 180 E R 0.608 Pathogenic PMS2 P54278 E180S 180 E S 0.522 Pathogenic PMS2 P54278 E180T 180 E T 0.616 Pathogenic PMS2 P54278 E180V 180 E V 0.412 Neutral PMS2 P54278 E180W 180 E W 0.964 Pathogenic PMS2 P54278 E180Y 180 E Y 0.922 Pathogenic PMS2 P54278 Y181A 181 Y A 0.218 Neutral PMS2 P54278 Y181C 181 Y C 0.312 Neutral PMS2 P54278 Y181D 181 Y D 0.55 Pathogenic PMS2 P54278 Y181E 181 Y E 0.546 Pathogenic PMS2 P54278 Y181F 181 Y F 0.048 Neutral PMS2 P54278 Y181G 181 Y G 0.258 Neutral PMS2 P54278 Y181H 181 Y H 0.216 Neutral PMS2 P54278 Y181I 181 Y I 0.46 Neutral PMS2 P54278 Y181K 181 Y K 0.53 Pathogenic PMS2 P54278 Y181L 181 Y L 0.278 Neutral PMS2 P54278 Y181M 181 Y M 0.31 Neutral PMS2 P54278 Y181N 181 Y N 0.382 Neutral PMS2 P54278 Y181P 181 Y P 0.386 Neutral PMS2 P54278 Y181Q 181 Y Q 0.352 Neutral PMS2 P54278 Y181R 181 Y R 0.108 Neutral PMS2 P54278 Y181S 181 Y S 0.262 Neutral PMS2 P54278 Y181T 181 Y T 0.316 Neutral PMS2 P54278 Y181V 181 Y V 0.458 Neutral PMS2 P54278 Y181W 181 Y W 0.074 Neutral PMS2 P54278 A182C 182 A C 0.242 Neutral PMS2 P54278 A182D 182 A D 0.498 Neutral PMS2 P54278 A182E 182 A E 0.542 Pathogenic PMS2 P54278 A182F 182 A F 0.71 Pathogenic PMS2 P54278 A182G 182 A G 0.004 Neutral PMS2 P54278 A182H 182 A H 0.384 Neutral PMS2 P54278 A182I 182 A I 0.514 Pathogenic PMS2 P54278 A182K 182 A K 0.626 Pathogenic PMS2 P54278 A182L 182 A L 0.708 Pathogenic PMS2 P54278 A182M 182 A M 0.526 Pathogenic PMS2 P54278 A182N 182 A N 0.426 Neutral PMS2 P54278 A182P 182 A P 0.47 Neutral PMS2 P54278 A182Q 182 A Q 0.378 Neutral PMS2 P54278 A182R 182 A R 0.622 Pathogenic PMS2 P54278 A182S 182 A S 0.006 Neutral PMS2 P54278 A182T 182 A T 0.022 Neutral PMS2 P54278 A182V 182 A V 0.062 Neutral PMS2 P54278 A182W 182 A W 0.784 Pathogenic PMS2 P54278 A182Y 182 A Y 0.788 Pathogenic PMS2 P54278 K183A 183 K A 0.242 Neutral PMS2 P54278 K183C 183 K C 0.196 Neutral PMS2 P54278 K183D 183 K D 0.308 Neutral PMS2 P54278 K183E 183 K E 0.162 Neutral PMS2 P54278 K183F 183 K F 0.846 Pathogenic PMS2 P54278 K183G 183 K G 0.314 Neutral PMS2 P54278 K183H 183 K H 0.392 Neutral PMS2 P54278 K183I 183 K I 0.754 Pathogenic PMS2 P54278 K183L 183 K L 0.86 Pathogenic PMS2 P54278 K183M 183 K M 0.66 Pathogenic PMS2 P54278 K183N 183 K N 0.35 Neutral PMS2 P54278 K183P 183 K P 0.832 Pathogenic PMS2 P54278 K183Q 183 K Q 0.174 Neutral PMS2 P54278 K183R 183 K R 0.03 Neutral PMS2 P54278 K183S 183 K S 0.436 Neutral PMS2 P54278 K183T 183 K T 0.284 Neutral PMS2 P54278 K183V 183 K V 0.41 Neutral PMS2 P54278 K183W 183 K W 0.98 Pathogenic PMS2 P54278 K183Y 183 K Y 0.934 Pathogenic PMS2 P54278 M184A 184 M A 0.112 Neutral PMS2 P54278 M184C 184 M C 0.21 Neutral PMS2 P54278 M184D 184 M D 0.628 Pathogenic PMS2 P54278 M184E 184 M E 0.34 Neutral PMS2 P54278 M184F 184 M F 0.746 Pathogenic PMS2 P54278 M184G 184 M G 0.36 Neutral PMS2 P54278 M184H 184 M H 0.33 Neutral PMS2 P54278 M184I 184 M I 0.292 Neutral PMS2 P54278 M184K 184 M K 0.478 Neutral PMS2 P54278 M184L 184 M L 0.034 Neutral PMS2 P54278 M184N 184 M N 0.384 Neutral PMS2 P54278 M184P 184 M P 0.812 Pathogenic PMS2 P54278 M184Q 184 M Q 0.284 Neutral PMS2 P54278 M184R 184 M R 0.594 Pathogenic PMS2 P54278 M184S 184 M S 0.52 Pathogenic PMS2 P54278 M184T 184 M T 0.098 Neutral PMS2 P54278 M184V 184 M V 0.052 Neutral PMS2 P54278 M184W 184 M W 0.898 Pathogenic PMS2 P54278 M184Y 184 M Y 0.836 Pathogenic PMS2 P54278 V185A 185 V A 0.004 Neutral PMS2 P54278 V185C 185 V C 0.012 Neutral PMS2 P54278 V185D 185 V D 0.208 Neutral PMS2 P54278 V185E 185 V E 0.338 Neutral PMS2 P54278 V185F 185 V F 0.434 Neutral PMS2 P54278 V185G 185 V G 0.302 Neutral PMS2 P54278 V185H 185 V H 0.258 Neutral PMS2 P54278 V185I 185 V I 0.018 Neutral PMS2 P54278 V185K 185 V K 0.334 Neutral PMS2 P54278 V185L 185 V L 0.004 Neutral PMS2 P54278 V185M 185 V M 0.028 Neutral PMS2 P54278 V185N 185 V N 0.23 Neutral PMS2 P54278 V185P 185 V P 0.372 Neutral PMS2 P54278 V185Q 185 V Q 0.092 Neutral PMS2 P54278 V185R 185 V R 0.558 Pathogenic PMS2 P54278 V185S 185 V S 0.112 Neutral PMS2 P54278 V185T 185 V T 0.01 Neutral PMS2 P54278 V185W 185 V W 0.608 Pathogenic PMS2 P54278 V185Y 185 V Y 0.536 Pathogenic PMS2 P54278 Q186A 186 Q A 0.1 Neutral PMS2 P54278 Q186C 186 Q C 0.394 Neutral PMS2 P54278 Q186D 186 Q D 0.018 Neutral PMS2 P54278 Q186E 186 Q E 0.022 Neutral PMS2 P54278 Q186F 186 Q F 0.534 Pathogenic PMS2 P54278 Q186G 186 Q G 0.096 Neutral PMS2 P54278 Q186H 186 Q H 0.056 Neutral PMS2 P54278 Q186I 186 Q I 0.852 Pathogenic PMS2 P54278 Q186K 186 Q K 0.06 Neutral PMS2 P54278 Q186L 186 Q L 0.778 Pathogenic PMS2 P54278 Q186M 186 Q M 0.666 Pathogenic PMS2 P54278 Q186N 186 Q N 0.058 Neutral PMS2 P54278 Q186P 186 Q P 0.308 Neutral PMS2 P54278 Q186R 186 Q R 0.052 Neutral PMS2 P54278 Q186S 186 Q S 0.078 Neutral PMS2 P54278 Q186T 186 Q T 0.032 Neutral PMS2 P54278 Q186V 186 Q V 0.79 Pathogenic PMS2 P54278 Q186W 186 Q W 0.886 Pathogenic PMS2 P54278 Q186Y 186 Q Y 0.836 Pathogenic PMS2 P54278 V187A 187 V A 0.016 Neutral PMS2 P54278 V187C 187 V C 0.394 Neutral PMS2 P54278 V187D 187 V D 0.602 Pathogenic PMS2 P54278 V187E 187 V E 0.706 Pathogenic PMS2 P54278 V187F 187 V F 0.546 Pathogenic PMS2 P54278 V187G 187 V G 0.246 Neutral PMS2 P54278 V187H 187 V H 0.544 Pathogenic PMS2 P54278 V187I 187 V I 0.054 Neutral PMS2 P54278 V187K 187 V K 0.19 Neutral PMS2 P54278 V187L 187 V L 0.036 Neutral PMS2 P54278 V187M 187 V M 0.074 Neutral PMS2 P54278 V187N 187 V N 0.49 Neutral PMS2 P54278 V187P 187 V P 0.86 Pathogenic PMS2 P54278 V187Q 187 V Q 0.72 Pathogenic PMS2 P54278 V187R 187 V R 0.746 Pathogenic PMS2 P54278 V187S 187 V S 0.268 Neutral PMS2 P54278 V187T 187 V T 0.024 Neutral PMS2 P54278 V187W 187 V W 0.84 Pathogenic PMS2 P54278 V187Y 187 V Y 0.662 Pathogenic PMS2 P54278 L188A 188 L A 0.562 Pathogenic PMS2 P54278 L188C 188 L C 0.682 Pathogenic PMS2 P54278 L188D 188 L D 0.902 Pathogenic PMS2 P54278 L188E 188 L E 0.882 Pathogenic PMS2 P54278 L188F 188 L F 0.452 Neutral PMS2 P54278 L188G 188 L G 0.464 Neutral PMS2 P54278 L188H 188 L H 0.802 Pathogenic PMS2 P54278 L188I 188 L I 0.136 Neutral PMS2 P54278 L188K 188 L K 0.746 Pathogenic PMS2 P54278 L188M 188 L M 0.184 Neutral PMS2 P54278 L188N 188 L N 0.772 Pathogenic PMS2 P54278 L188P 188 L P 0.998 Pathogenic PMS2 P54278 L188Q 188 L Q 0.618 Pathogenic PMS2 P54278 L188R 188 L R 0.996 Pathogenic PMS2 P54278 L188S 188 L S 0.336 Neutral PMS2 P54278 L188T 188 L T 0.586 Pathogenic PMS2 P54278 L188V 188 L V 0.086 Neutral PMS2 P54278 L188W 188 L W 0.658 Pathogenic PMS2 P54278 L188Y 188 L Y 0.824 Pathogenic PMS2 P54278 H189A 189 H A 0.25 Neutral PMS2 P54278 H189C 189 H C 0.23 Neutral PMS2 P54278 H189D 189 H D 0.204 Neutral PMS2 P54278 H189E 189 H E 0.012 Neutral PMS2 P54278 H189F 189 H F 0.702 Pathogenic PMS2 P54278 H189G 189 H G 0.08 Neutral PMS2 P54278 H189I 189 H I 0.754 Pathogenic PMS2 P54278 H189K 189 H K 0.026 Neutral PMS2 P54278 H189L 189 H L 0.384 Neutral PMS2 P54278 H189M 189 H M 0.566 Pathogenic PMS2 P54278 H189N 189 H N 0.018 Neutral PMS2 P54278 H189P 189 H P 0.886 Pathogenic PMS2 P54278 H189Q 189 H Q 0.03 Neutral PMS2 P54278 H189R 189 H R 0.016 Neutral PMS2 P54278 H189S 189 H S 0.028 Neutral PMS2 P54278 H189T 189 H T 0.022 Neutral PMS2 P54278 H189V 189 H V 0.538 Pathogenic PMS2 P54278 H189W 189 H W 0.912 Pathogenic PMS2 P54278 H189Y 189 H Y 0.068 Neutral PMS2 P54278 D19A 19 D A 0.096 Neutral PMS2 P54278 D19C 19 D C 0.66 Pathogenic PMS2 P54278 D19E 19 D E 0.022 Neutral PMS2 P54278 D19F 19 D F 0.872 Pathogenic PMS2 P54278 D19G 19 D G 0.044 Neutral PMS2 P54278 D19H 19 D H 0.334 Neutral PMS2 P54278 D19I 19 D I 0.82 Pathogenic PMS2 P54278 D19K 19 D K 0.674 Pathogenic PMS2 P54278 D19L 19 D L 0.816 Pathogenic PMS2 P54278 D19M 19 D M 0.736 Pathogenic PMS2 P54278 D19N 19 D N 0.008 Neutral PMS2 P54278 D19P 19 D P 0.092 Neutral PMS2 P54278 D19Q 19 D Q 0.526 Pathogenic PMS2 P54278 D19R 19 D R 0.522 Pathogenic PMS2 P54278 D19S 19 D S 0.012 Neutral PMS2 P54278 D19T 19 D T 0.516 Pathogenic PMS2 P54278 D19V 19 D V 0.854 Pathogenic PMS2 P54278 D19W 19 D W 0.93 Pathogenic PMS2 P54278 D19Y 19 D Y 0.922 Pathogenic PMS2 P54278 A190C 190 A C 0.716 Pathogenic PMS2 P54278 A190D 190 A D 0.856 Pathogenic PMS2 P54278 A190E 190 A E 0.884 Pathogenic PMS2 P54278 A190F 190 A F 0.968 Pathogenic PMS2 P54278 A190G 190 A G 0.03 Neutral PMS2 P54278 A190H 190 A H 0.558 Pathogenic PMS2 P54278 A190I 190 A I 0.93 Pathogenic PMS2 P54278 A190K 190 A K 0.916 Pathogenic PMS2 P54278 A190L 190 A L 0.948 Pathogenic PMS2 P54278 A190M 190 A M 0.838 Pathogenic PMS2 P54278 A190N 190 A N 0.788 Pathogenic PMS2 P54278 A190P 190 A P 0.872 Pathogenic PMS2 P54278 A190Q 190 A Q 0.518 Pathogenic PMS2 P54278 A190R 190 A R 0.926 Pathogenic PMS2 P54278 A190S 190 A S 0.018 Neutral PMS2 P54278 A190T 190 A T 0.228 Neutral PMS2 P54278 A190V 190 A V 0.72 Pathogenic PMS2 P54278 A190W 190 A W 0.954 Pathogenic PMS2 P54278 A190Y 190 A Y 0.79 Pathogenic PMS2 P54278 Y191A 191 Y A 0.23 Neutral PMS2 P54278 Y191C 191 Y C 0.24 Neutral PMS2 P54278 Y191D 191 Y D 0.584 Pathogenic PMS2 P54278 Y191E 191 Y E 0.572 Pathogenic PMS2 P54278 Y191F 191 Y F 0.058 Neutral PMS2 P54278 Y191G 191 Y G 0.278 Neutral PMS2 P54278 Y191H 191 Y H 0.104 Neutral PMS2 P54278 Y191I 191 Y I 0.264 Neutral PMS2 P54278 Y191K 191 Y K 0.57 Pathogenic PMS2 P54278 Y191L 191 Y L 0.126 Neutral PMS2 P54278 Y191M 191 Y M 0.348 Neutral PMS2 P54278 Y191N 191 Y N 0.41 Neutral PMS2 P54278 Y191P 191 Y P 0.428 Neutral PMS2 P54278 Y191Q 191 Y Q 0.374 Neutral PMS2 P54278 Y191R 191 Y R 0.61 Pathogenic PMS2 P54278 Y191S 191 Y S 0.282 Neutral PMS2 P54278 Y191T 191 Y T 0.144 Neutral PMS2 P54278 Y191V 191 Y V 0.406 Neutral PMS2 P54278 Y191W 191 Y W 0.556 Pathogenic PMS2 P54278 C192A 192 C A 0.058 Neutral PMS2 P54278 C192D 192 C D 0.524 Pathogenic PMS2 P54278 C192E 192 C E 0.584 Pathogenic PMS2 P54278 C192F 192 C F 0.966 Pathogenic PMS2 P54278 C192G 192 C G 0.206 Neutral PMS2 P54278 C192H 192 C H 0.754 Pathogenic PMS2 P54278 C192I 192 C I 0.834 Pathogenic PMS2 P54278 C192K 192 C K 0.652 Pathogenic PMS2 P54278 C192L 192 C L 0.454 Neutral PMS2 P54278 C192M 192 C M 0.596 Pathogenic PMS2 P54278 C192N 192 C N 0.286 Neutral PMS2 P54278 C192P 192 C P 0.856 Pathogenic PMS2 P54278 C192Q 192 C Q 0.506 Pathogenic PMS2 P54278 C192R 192 C R 0.914 Pathogenic PMS2 P54278 C192S 192 C S 0.228 Neutral PMS2 P54278 C192T 192 C T 0.524 Pathogenic PMS2 P54278 C192V 192 C V 0.204 Neutral PMS2 P54278 C192W 192 C W 0.952 Pathogenic PMS2 P54278 C192Y 192 C Y 0.96 Pathogenic PMS2 P54278 I193A 193 I A 0.06 Neutral PMS2 P54278 I193C 193 I C 0.06 Neutral PMS2 P54278 I193D 193 I D 0.094 Neutral PMS2 P54278 I193E 193 I E 0.088 Neutral PMS2 P54278 I193F 193 I F 0.686 Pathogenic PMS2 P54278 I193G 193 I G 0.548 Pathogenic PMS2 P54278 I193H 193 I H 0.44 Neutral PMS2 P54278 I193K 193 I K 0.088 Neutral PMS2 P54278 I193L 193 I L 0.064 Neutral PMS2 P54278 I193M 193 I M 0.054 Neutral PMS2 P54278 I193N 193 I N 0.652 Pathogenic PMS2 P54278 I193P 193 I P 0.702 Pathogenic PMS2 P54278 I193Q 193 I Q 0.152 Neutral PMS2 P54278 I193R 193 I R 0.792 Pathogenic PMS2 P54278 I193S 193 I S 0.11 Neutral PMS2 P54278 I193T 193 I T 0.082 Neutral PMS2 P54278 I193V 193 I V 0.022 Neutral PMS2 P54278 I193W 193 I W 0.898 Pathogenic PMS2 P54278 I193Y 193 I Y 0.904 Pathogenic PMS2 P54278 I194A 194 I A 0.476 Neutral PMS2 P54278 I194C 194 I C 0.628 Pathogenic PMS2 P54278 I194D 194 I D 0.78 Pathogenic PMS2 P54278 I194E 194 I E 0.784 Pathogenic PMS2 P54278 I194F 194 I F 0.316 Neutral PMS2 P54278 I194G 194 I G 0.818 Pathogenic PMS2 P54278 I194H 194 I H 0.844 Pathogenic PMS2 P54278 I194K 194 I K 0.856 Pathogenic PMS2 P54278 I194L 194 I L 0.11 Neutral PMS2 P54278 I194M 194 I M 0.398 Neutral PMS2 P54278 I194N 194 I N 0.258 Neutral PMS2 P54278 I194P 194 I P 0.922 Pathogenic PMS2 P54278 I194Q 194 I Q 0.812 Pathogenic PMS2 P54278 I194R 194 I R 0.892 Pathogenic PMS2 P54278 I194S 194 I S 0.172 Neutral PMS2 P54278 I194T 194 I T 0.17 Neutral PMS2 P54278 I194V 194 I V 0.134 Neutral PMS2 P54278 I194W 194 I W 0.956 Pathogenic PMS2 P54278 I194Y 194 I Y 0.95 Pathogenic PMS2 P54278 S195A 195 S A 0.046 Neutral PMS2 P54278 S195C 195 S C 0.078 Neutral PMS2 P54278 S195D 195 S D 0.582 Pathogenic PMS2 P54278 S195E 195 S E 0.77 Pathogenic PMS2 P54278 S195F 195 S F 0.898 Pathogenic PMS2 P54278 S195G 195 S G 0.098 Neutral PMS2 P54278 S195H 195 S H 0.67 Pathogenic PMS2 P54278 S195I 195 S I 0.66 Pathogenic PMS2 P54278 S195K 195 S K 0.774 Pathogenic PMS2 P54278 S195L 195 S L 0.548 Pathogenic PMS2 P54278 S195M 195 S M 0.974 Pathogenic PMS2 P54278 S195N 195 S N 0.208 Neutral PMS2 P54278 S195P 195 S P 0.188 Neutral PMS2 P54278 S195Q 195 S Q 0.482 Neutral PMS2 P54278 S195R 195 S R 0.474 Neutral PMS2 P54278 S195T 195 S T 0.064 Neutral PMS2 P54278 S195V 195 S V 0.814 Pathogenic PMS2 P54278 S195W 195 S W 0.936 Pathogenic PMS2 P54278 S195Y 195 S Y 0.892 Pathogenic PMS2 P54278 A196C 196 A C 0.724 Pathogenic PMS2 P54278 A196D 196 A D 0.854 Pathogenic PMS2 P54278 A196E 196 A E 0.606 Pathogenic PMS2 P54278 A196F 196 A F 0.614 Pathogenic PMS2 P54278 A196G 196 A G 0.202 Neutral PMS2 P54278 A196H 196 A H 0.87 Pathogenic PMS2 P54278 A196I 196 A I 0.616 Pathogenic PMS2 P54278 A196K 196 A K 0.548 Pathogenic PMS2 P54278 A196L 196 A L 0.922 Pathogenic PMS2 P54278 A196M 196 A M 0.836 Pathogenic PMS2 P54278 A196N 196 A N 0.658 Pathogenic PMS2 P54278 A196P 196 A P 0.278 Neutral PMS2 P54278 A196Q 196 A Q 0.744 Pathogenic PMS2 P54278 A196R 196 A R 0.634 Pathogenic PMS2 P54278 A196S 196 A S 0.018 Neutral PMS2 P54278 A196T 196 A T 0.058 Neutral PMS2 P54278 A196V 196 A V 0.132 Neutral PMS2 P54278 A196W 196 A W 0.954 Pathogenic PMS2 P54278 A196Y 196 A Y 0.78 Pathogenic PMS2 P54278 G197A 197 G A 0.088 Neutral PMS2 P54278 G197C 197 G C 0.72 Pathogenic PMS2 P54278 G197D 197 G D 0.458 Neutral PMS2 P54278 G197E 197 G E 0.552 Pathogenic PMS2 P54278 G197F 197 G F 0.95 Pathogenic PMS2 P54278 G197H 197 G H 0.764 Pathogenic PMS2 P54278 G197I 197 G I 0.69 Pathogenic PMS2 P54278 G197K 197 G K 0.6 Pathogenic PMS2 P54278 G197L 197 G L 0.624 Pathogenic PMS2 P54278 G197M 197 G M 0.988 Pathogenic PMS2 P54278 G197N 197 G N 0.478 Neutral PMS2 P54278 G197P 197 G P 0.936 Pathogenic PMS2 P54278 G197Q 197 G Q 0.546 Pathogenic PMS2 P54278 G197R 197 G R 0.602 Pathogenic PMS2 P54278 G197S 197 G S 0.114 Neutral PMS2 P54278 G197T 197 G T 0.572 Pathogenic PMS2 P54278 G197V 197 G V 0.618 Pathogenic PMS2 P54278 G197W 197 G W 0.966 Pathogenic PMS2 P54278 G197Y 197 G Y 0.958 Pathogenic PMS2 P54278 I198A 198 I A 0.168 Neutral PMS2 P54278 I198C 198 I C 0.604 Pathogenic PMS2 P54278 I198D 198 I D 0.774 Pathogenic PMS2 P54278 I198E 198 I E 0.77 Pathogenic PMS2 P54278 I198F 198 I F 0.29 Neutral PMS2 P54278 I198G 198 I G 0.81 Pathogenic PMS2 P54278 I198H 198 I H 0.774 Pathogenic PMS2 P54278 I198K 198 I K 0.502 Pathogenic PMS2 P54278 I198L 198 I L 0.092 Neutral PMS2 P54278 I198M 198 I M 0.372 Neutral PMS2 P54278 I198N 198 I N 0.802 Pathogenic PMS2 P54278 I198P 198 I P 0.866 Pathogenic PMS2 P54278 I198Q 198 I Q 0.798 Pathogenic PMS2 P54278 I198R 198 I R 0.88 Pathogenic PMS2 P54278 I198S 198 I S 0.56 Pathogenic PMS2 P54278 I198T 198 I T 0.106 Neutral PMS2 P54278 I198V 198 I V 0.294 Neutral PMS2 P54278 I198W 198 I W 0.84 Pathogenic PMS2 P54278 I198Y 198 I Y 0.836 Pathogenic PMS2 P54278 R199A 199 R A 0.116 Neutral PMS2 P54278 R199C 199 R C 0.492 Neutral PMS2 P54278 R199D 199 R D 0.062 Neutral PMS2 P54278 R199E 199 R E 0.062 Neutral PMS2 P54278 R199F 199 R F 0.936 Pathogenic PMS2 P54278 R199G 199 R G 0.212 Neutral PMS2 P54278 R199H 199 R H 0.074 Neutral PMS2 P54278 R199I 199 R I 0.18 Neutral PMS2 P54278 R199K 199 R K 0.034 Neutral PMS2 P54278 R199L 199 R L 0.212 Neutral PMS2 P54278 R199M 199 R M 0.678 Pathogenic PMS2 P54278 R199N 199 R N 0.028 Neutral PMS2 P54278 R199P 199 R P 0.848 Pathogenic PMS2 P54278 R199Q 199 R Q 0.022 Neutral PMS2 P54278 R199S 199 R S 0.058 Neutral PMS2 P54278 R199T 199 R T 0.064 Neutral PMS2 P54278 R199V 199 R V 0.11 Neutral PMS2 P54278 R199W 199 R W 0.914 Pathogenic PMS2 P54278 R199Y 199 R Y 0.896 Pathogenic PMS2 P54278 E2A 2 E A 0.144 Neutral PMS2 P54278 E2C 2 E C 0.09 Neutral PMS2 P54278 E2D 2 E D 0.004 Neutral PMS2 P54278 E2F 2 E F 0.058 Neutral PMS2 P54278 E2G 2 E G 0.084 Neutral PMS2 P54278 E2H 2 E H 0.104 Neutral PMS2 P54278 E2I 2 E I 0.254 Neutral PMS2 P54278 E2K 2 E K 0.026 Neutral PMS2 P54278 E2L 2 E L 0.038 Neutral PMS2 P54278 E2M 2 E M 0.164 Neutral PMS2 P54278 E2N 2 E N 0.056 Neutral PMS2 P54278 E2P 2 E P 0.124 Neutral PMS2 P54278 E2Q 2 E Q 0 Neutral PMS2 P54278 E2R 2 E R 0.036 Neutral PMS2 P54278 E2S 2 E S 0.168 Neutral PMS2 P54278 E2T 2 E T 0.006 Neutral PMS2 P54278 E2V 2 E V 0.034 Neutral PMS2 P54278 E2W 2 E W 0.43 Neutral PMS2 P54278 E2Y 2 E Y 0.398 Neutral PMS2 P54278 R20A 20 R A 0.052 Neutral PMS2 P54278 R20C 20 R C 0.346 Neutral PMS2 P54278 R20D 20 R D 0.03 Neutral PMS2 P54278 R20E 20 R E 0.044 Neutral PMS2 P54278 R20F 20 R F 0.256 Neutral PMS2 P54278 R20G 20 R G 0.006 Neutral PMS2 P54278 R20H 20 R H 0.012 Neutral PMS2 P54278 R20I 20 R I 0.128 Neutral PMS2 P54278 R20K 20 R K 0.026 Neutral PMS2 P54278 R20L 20 R L 0.048 Neutral PMS2 P54278 R20M 20 R M 0.322 Neutral PMS2 P54278 R20N 20 R N 0.128 Neutral PMS2 P54278 R20P 20 R P 0.066 Neutral PMS2 P54278 R20Q 20 R Q 0.014 Neutral 1 PMS2 P54278 R20S 20 R S 0.028 Neutral PMS2 P54278 R20T 20 R T 0.028 Neutral PMS2 P54278 R20V 20 R V 0.41 Neutral PMS2 P54278 R20W 20 R W 0.652 Pathogenic PMS2 P54278 R20Y 20 R Y 0.518 Pathogenic PMS2 P54278 V200A 200 V A 0.146 Neutral PMS2 P54278 V200C 200 V C 0.242 Neutral PMS2 P54278 V200D 200 V D 0.438 Neutral PMS2 P54278 V200E 200 V E 0.122 Neutral PMS2 P54278 V200F 200 V F 0.46 Neutral PMS2 P54278 V200G 200 V G 0.64 Pathogenic PMS2 P54278 V200H 200 V H 0.328 Neutral PMS2 P54278 V200I 200 V I 0.092 Neutral PMS2 P54278 V200K 200 V K 0.802 Pathogenic PMS2 P54278 V200L 200 V L 0.052 Neutral PMS2 P54278 V200M 200 V M 0.506 Pathogenic PMS2 P54278 V200N 200 V N 0.658 Pathogenic PMS2 P54278 V200P 200 V P 0.87 Pathogenic PMS2 P54278 V200Q 200 V Q 0.736 Pathogenic PMS2 P54278 V200R 200 V R 0.842 Pathogenic PMS2 P54278 V200S 200 V S 0.456 Neutral PMS2 P54278 V200T 200 V T 0.048 Neutral PMS2 P54278 V200W 200 V W 0.686 Pathogenic PMS2 P54278 V200Y 200 V Y 0.664 Pathogenic PMS2 P54278 S201A 201 S A 0.374 Neutral PMS2 P54278 S201C 201 S C 0.3 Neutral PMS2 P54278 S201D 201 S D 0.088 Neutral PMS2 P54278 S201E 201 S E 0.452 Neutral PMS2 P54278 S201F 201 S F 0.768 Pathogenic PMS2 P54278 S201G 201 S G 0.128 Neutral PMS2 P54278 S201H 201 S H 0.658 Pathogenic PMS2 P54278 S201I 201 S I 0.32 Neutral PMS2 P54278 S201K 201 S K 0.458 Neutral PMS2 P54278 S201L 201 S L 0.144 Neutral PMS2 P54278 S201M 201 S M 0.932 Pathogenic PMS2 P54278 S201N 201 S N 0.048 Neutral PMS2 P54278 S201P 201 S P 0.558 Pathogenic PMS2 P54278 S201Q 201 S Q 0.458 Neutral PMS2 P54278 S201R 201 S R 0.658 Pathogenic PMS2 P54278 S201T 201 S T 0.06 Neutral PMS2 P54278 S201V 201 S V 0.092 Neutral PMS2 P54278 S201W 201 S W 0.928 Pathogenic PMS2 P54278 S201Y 201 S Y 0.902 Pathogenic PMS2 P54278 C202A 202 C A 0.066 Neutral PMS2 P54278 C202D 202 C D 0.06 Neutral PMS2 P54278 C202E 202 C E 0.092 Neutral PMS2 P54278 C202F 202 C F 0.924 Pathogenic PMS2 P54278 C202G 202 C G 0.054 Neutral PMS2 P54278 C202H 202 C H 0.498 Neutral PMS2 P54278 C202I 202 C I 0.836 Pathogenic PMS2 P54278 C202K 202 C K 0.118 Neutral PMS2 P54278 C202L 202 C L 0.094 Neutral PMS2 P54278 C202M 202 C M 0.108 Neutral PMS2 P54278 C202N 202 C N 0.334 Neutral PMS2 P54278 C202P 202 C P 0.098 Neutral PMS2 P54278 C202Q 202 C Q 0.032 Neutral PMS2 P54278 C202R 202 C R 0.916 Pathogenic PMS2 P54278 C202S 202 C S 0.072 Neutral PMS2 P54278 C202T 202 C T 0.02 Neutral PMS2 P54278 C202V 202 C V 0.056 Neutral PMS2 P54278 C202W 202 C W 0.954 Pathogenic PMS2 P54278 C202Y 202 C Y 0.742 Pathogenic PMS2 P54278 T203A 203 T A 0.114 Neutral PMS2 P54278 T203C 203 T C 0.458 Neutral PMS2 P54278 T203D 203 T D 0.118 Neutral PMS2 P54278 T203E 203 T E 0.154 Neutral PMS2 P54278 T203F 203 T F 0.452 Neutral PMS2 P54278 T203G 203 T G 0.066 Neutral PMS2 P54278 T203H 203 T H 0.2 Neutral PMS2 P54278 T203I 203 T I 0.17 Neutral PMS2 P54278 T203K 203 T K 0.188 Neutral PMS2 P54278 T203L 203 T L 0.512 Pathogenic PMS2 P54278 T203M 203 T M 0.636 Pathogenic PMS2 P54278 T203N 203 T N 0.028 Neutral PMS2 P54278 T203P 203 T P 0.528 Pathogenic PMS2 P54278 T203Q 203 T Q 0.036 Neutral PMS2 P54278 T203R 203 T R 0.476 Neutral PMS2 P54278 T203S 203 T S 0.03 Neutral PMS2 P54278 T203V 203 T V 0.096 Neutral PMS2 P54278 T203W 203 T W 0.908 Pathogenic PMS2 P54278 T203Y 203 T Y 0.578 Pathogenic PMS2 P54278 N204A 204 N A 0.068 Neutral PMS2 P54278 N204C 204 N C 0.578 Pathogenic PMS2 P54278 N204D 204 N D 0.032 Neutral PMS2 P54278 N204E 204 N E 0.132 Neutral PMS2 P54278 N204F 204 N F 0.916 Pathogenic PMS2 P54278 N204G 204 N G 0.13 Neutral PMS2 P54278 N204H 204 N H 0.082 Neutral PMS2 P54278 N204I 204 N I 0.85 Pathogenic PMS2 P54278 N204K 204 N K 0.81 Pathogenic PMS2 P54278 N204L 204 N L 0.876 Pathogenic PMS2 P54278 N204M 204 N M 0.862 Pathogenic PMS2 P54278 N204P 204 N P 0.23 Neutral PMS2 P54278 N204Q 204 N Q 0.04 Neutral PMS2 P54278 N204R 204 N R 0.764 Pathogenic PMS2 P54278 N204S 204 N S 0.432 Neutral PMS2 P54278 N204T 204 N T 0.502 Pathogenic PMS2 P54278 N204V 204 N V 0.928 Pathogenic PMS2 P54278 N204W 204 N W 0.942 Pathogenic PMS2 P54278 N204Y 204 N Y 0.934 Pathogenic PMS2 P54278 Q205A 205 Q A 0.166 Neutral PMS2 P54278 Q205C 205 Q C 0.34 Neutral PMS2 P54278 Q205D 205 Q D 0.062 Neutral PMS2 P54278 Q205E 205 Q E 0.034 Neutral PMS2 P54278 Q205F 205 Q F 0.57 Pathogenic PMS2 P54278 Q205G 205 Q G 0.45 Neutral PMS2 P54278 Q205H 205 Q H 0.104 Neutral PMS2 P54278 Q205I 205 Q I 0.454 Neutral PMS2 P54278 Q205K 205 Q K 0.404 Neutral PMS2 P54278 Q205L 205 Q L 0.202 Neutral PMS2 P54278 Q205M 205 Q M 0.71 Pathogenic PMS2 P54278 Q205N 205 Q N 0.128 Neutral PMS2 P54278 Q205P 205 Q P 0.334 Neutral PMS2 P54278 Q205R 205 Q R 0.398 Neutral PMS2 P54278 Q205S 205 Q S 0.102 Neutral PMS2 P54278 Q205T 205 Q T 0.036 Neutral PMS2 P54278 Q205V 205 Q V 0.238 Neutral PMS2 P54278 Q205W 205 Q W 0.93 Pathogenic PMS2 P54278 Q205Y 205 Q Y 0.89 Pathogenic PMS2 P54278 L206A 206 L A 0.068 Neutral PMS2 P54278 L206C 206 L C 0.198 Neutral PMS2 P54278 L206D 206 L D 0.562 Pathogenic PMS2 P54278 L206E 206 L E 0.526 Pathogenic PMS2 P54278 L206F 206 L F 0.736 Pathogenic PMS2 P54278 L206G 206 L G 0.39 Neutral PMS2 P54278 L206H 206 L H 0.298 Neutral PMS2 P54278 L206I 206 L I 0.074 Neutral PMS2 P54278 L206K 206 L K 0.236 Neutral PMS2 P54278 L206M 206 L M 0.032 Neutral PMS2 P54278 L206N 206 L N 0.1 Neutral PMS2 P54278 L206P 206 L P 0.224 Neutral PMS2 P54278 L206Q 206 L Q 0.164 Neutral PMS2 P54278 L206R 206 L R 0.808 Pathogenic PMS2 P54278 L206S 206 L S 0.058 Neutral PMS2 P54278 L206T 206 L T 0.04 Neutral PMS2 P54278 L206V 206 L V 0.06 Neutral PMS2 P54278 L206W 206 L W 0.828 Pathogenic PMS2 P54278 L206Y 206 L Y 0.82 Pathogenic PMS2 P54278 G207A 207 G A 0.066 Neutral PMS2 P54278 G207C 207 G C 0.518 Pathogenic PMS2 P54278 G207D 207 G D 0.472 Neutral PMS2 P54278 G207E 207 G E 0.548 Pathogenic PMS2 P54278 G207F 207 G F 0.978 Pathogenic PMS2 P54278 G207H 207 G H 0.974 Pathogenic PMS2 P54278 G207I 207 G I 0.698 Pathogenic PMS2 P54278 G207K 207 G K 0.608 Pathogenic PMS2 P54278 G207L 207 G L 0.772 Pathogenic PMS2 P54278 G207M 207 G M 0.608 Pathogenic PMS2 P54278 G207N 207 G N 0.478 Neutral PMS2 P54278 G207P 207 G P 0.62 Pathogenic PMS2 P54278 G207Q 207 G Q 0.742 Pathogenic PMS2 P54278 G207R 207 G R 0.916 Pathogenic PMS2 P54278 G207S 207 G S 0.096 Neutral PMS2 P54278 G207T 207 G T 0.572 Pathogenic PMS2 P54278 G207V 207 G V 0.616 Pathogenic PMS2 P54278 G207W 207 G W 0.966 Pathogenic PMS2 P54278 G207Y 207 G Y 0.958 Pathogenic PMS2 P54278 Q208A 208 Q A 0.278 Neutral PMS2 P54278 Q208C 208 Q C 0.086 Neutral PMS2 P54278 Q208D 208 Q D 0.074 Neutral PMS2 P54278 Q208E 208 Q E 0.044 Neutral PMS2 P54278 Q208F 208 Q F 0.81 Pathogenic PMS2 P54278 Q208G 208 Q G 0.122 Neutral PMS2 P54278 Q208H 208 Q H 0.1 Neutral PMS2 P54278 Q208I 208 Q I 0.86 Pathogenic PMS2 P54278 Q208K 208 Q K 0.216 Neutral PMS2 P54278 Q208L 208 Q L 0.792 Pathogenic PMS2 P54278 Q208M 208 Q M 0.71 Pathogenic PMS2 P54278 Q208N 208 Q N 0.104 Neutral PMS2 P54278 Q208P 208 Q P 0.846 Pathogenic PMS2 P54278 Q208R 208 Q R 0.094 Neutral PMS2 P54278 Q208S 208 Q S 0.108 Neutral PMS2 P54278 Q208T 208 Q T 0.052 Neutral PMS2 P54278 Q208V 208 Q V 0.754 Pathogenic PMS2 P54278 Q208W 208 Q W 0.93 Pathogenic PMS2 P54278 Q208Y 208 Q Y 0.924 Pathogenic PMS2 P54278 G209A 209 G A 0.336 Neutral PMS2 P54278 G209C 209 G C 0.73 Pathogenic PMS2 P54278 G209D 209 G D 0.462 Neutral PMS2 P54278 G209E 209 G E 0.908 Pathogenic PMS2 P54278 G209F 209 G F 0.956 Pathogenic PMS2 P54278 G209H 209 G H 0.95 Pathogenic PMS2 P54278 G209I 209 G I 0.79 Pathogenic PMS2 P54278 G209K 209 G K 0.576 Pathogenic PMS2 P54278 G209L 209 G L 0.922 Pathogenic PMS2 P54278 G209M 209 G M 0.95 Pathogenic PMS2 P54278 G209N 209 G N 0.438 Neutral PMS2 P54278 G209P 209 G P 0.914 Pathogenic PMS2 P54278 G209Q 209 G Q 0.794 Pathogenic PMS2 P54278 G209R 209 G R 0.966 Pathogenic PMS2 P54278 G209S 209 G S 0.158 Neutral PMS2 P54278 G209T 209 G T 0.562 Pathogenic PMS2 P54278 G209V 209 G V 0.934 Pathogenic PMS2 P54278 G209W 209 G W 0.946 Pathogenic PMS2 P54278 G209Y 209 G Y 0.922 Pathogenic PMS2 P54278 K21A 21 K A 0.032 Neutral PMS2 P54278 K21C 21 K C 0.054 Neutral PMS2 P54278 K21D 21 K D 0.002 Neutral PMS2 P54278 K21E 21 K E 0.004 Neutral PMS2 P54278 K21F 21 K F 0.356 Neutral PMS2 P54278 K21G 21 K G 0.048 Neutral PMS2 P54278 K21H 21 K H 0 Neutral PMS2 P54278 K21I 21 K I 0.398 Neutral PMS2 P54278 K21L 21 K L 0.164 Neutral PMS2 P54278 K21M 21 K M 0.184 Neutral PMS2 P54278 K21N 21 K N 0.008 Neutral PMS2 P54278 K21P 21 K P 0.07 Neutral PMS2 P54278 K21Q 21 K Q 0.01 Neutral PMS2 P54278 K21R 21 K R 0.01 Neutral PMS2 P54278 K21S 21 K S 0.014 Neutral PMS2 P54278 K21T 21 K T 0.02 Neutral PMS2 P54278 K21V 21 K V 0.174 Neutral PMS2 P54278 K21W 21 K W 0.63 Pathogenic PMS2 P54278 K21Y 21 K Y 0.566 Pathogenic PMS2 P54278 K210A 210 K A 0.078 Neutral PMS2 P54278 K210C 210 K C 0.182 Neutral PMS2 P54278 K210D 210 K D 0.236 Neutral PMS2 P54278 K210E 210 K E 0.258 Neutral PMS2 P54278 K210F 210 K F 0.646 Pathogenic PMS2 P54278 K210G 210 K G 0.1 Neutral PMS2 P54278 K210H 210 K H 0.198 Neutral PMS2 P54278 K210I 210 K I 0.692 Pathogenic PMS2 P54278 K210L 210 K L 0.65 Pathogenic PMS2 P54278 K210M 210 K M 0.286 Neutral PMS2 P54278 K210N 210 K N 0.272 Neutral PMS2 P54278 K210P 210 K P 0.072 Neutral PMS2 P54278 K210Q 210 K Q 0.152 Neutral PMS2 P54278 K210R 210 K R 0.032 Neutral PMS2 P54278 K210S 210 K S 0.064 Neutral PMS2 P54278 K210T 210 K T 0.286 Neutral PMS2 P54278 K210V 210 K V 0.092 Neutral PMS2 P54278 K210W 210 K W 0.874 Pathogenic PMS2 P54278 K210Y 210 K Y 0.796 Pathogenic PMS2 P54278 R211A 211 R A 0.37 Neutral PMS2 P54278 R211C 211 R C 0.616 Pathogenic PMS2 P54278 R211D 211 R D 0.604 Pathogenic PMS2 P54278 R211E 211 R E 0.556 Pathogenic PMS2 P54278 R211F 211 R F 0.858 Pathogenic PMS2 P54278 R211G 211 R G 0.154 Neutral PMS2 P54278 R211H 211 R H 0.482 Neutral PMS2 P54278 R211I 211 R I 0.874 Pathogenic PMS2 P54278 R211K 211 R K 0.112 Neutral PMS2 P54278 R211L 211 R L 0.85 Pathogenic PMS2 P54278 R211M 211 R M 0.626 Pathogenic PMS2 P54278 R211N 211 R N 0.02 Neutral PMS2 P54278 R211P 211 R P 0.14 Neutral PMS2 P54278 R211Q 211 R Q 0.028 Neutral PMS2 P54278 R211S 211 R S 0.038 Neutral PMS2 P54278 R211T 211 R T 0.524 Pathogenic PMS2 P54278 R211V 211 R V 0.786 Pathogenic PMS2 P54278 R211W 211 R W 0.856 Pathogenic PMS2 P54278 R211Y 211 R Y 0.818 Pathogenic PMS2 P54278 Q212A 212 Q A 0.218 Neutral PMS2 P54278 Q212C 212 Q C 0.348 Neutral PMS2 P54278 Q212D 212 Q D 0.398 Neutral PMS2 P54278 Q212E 212 Q E 0.59 Pathogenic PMS2 P54278 Q212F 212 Q F 0.756 Pathogenic PMS2 P54278 Q212G 212 Q G 0.44 Neutral PMS2 P54278 Q212H 212 Q H 0.056 Neutral PMS2 P54278 Q212I 212 Q I 0.33 Neutral PMS2 P54278 Q212K 212 Q K 0.036 Neutral PMS2 P54278 Q212L 212 Q L 0.778 Pathogenic PMS2 P54278 Q212M 212 Q M 0.048 Neutral PMS2 P54278 Q212N 212 Q N 0.06 Neutral PMS2 P54278 Q212P 212 Q P 0.812 Pathogenic PMS2 P54278 Q212R 212 Q R 0.046 Neutral PMS2 P54278 Q212S 212 Q S 0.08 Neutral PMS2 P54278 Q212T 212 Q T 0.02 Neutral PMS2 P54278 Q212V 212 Q V 0.076 Neutral PMS2 P54278 Q212W 212 Q W 0.886 Pathogenic PMS2 P54278 Q212Y 212 Q Y 0.646 Pathogenic PMS2 P54278 P213A 213 P A 0.072 Neutral PMS2 P54278 P213C 213 P C 0.068 Neutral PMS2 P54278 P213D 213 P D 0.078 Neutral PMS2 P54278 P213E 213 P E 0.632 Pathogenic PMS2 P54278 P213F 213 P F 0.534 Pathogenic PMS2 P54278 P213G 213 P G 0.296 Neutral PMS2 P54278 P213H 213 P H 0.592 Pathogenic PMS2 P54278 P213I 213 P I 0.084 Neutral PMS2 P54278 P213K 213 P K 0.158 Neutral PMS2 P54278 P213L 213 P L 0.084 Neutral PMS2 P54278 P213M 213 P M 0.194 Neutral PMS2 P54278 P213N 213 P N 0.148 Neutral PMS2 P54278 P213Q 213 P Q 0.118 Neutral PMS2 P54278 P213R 213 P R 0.724 Pathogenic PMS2 P54278 P213S 213 P S 0.044 Neutral PMS2 P54278 P213T 213 P T 0.042 Neutral PMS2 P54278 P213V 213 P V 0.182 Neutral PMS2 P54278 P213W 213 P W 0.826 Pathogenic PMS2 P54278 P213Y 213 P Y 0.518 Pathogenic PMS2 P54278 V214A 214 V A 0.022 Neutral PMS2 P54278 V214C 214 V C 0.384 Neutral PMS2 P54278 V214D 214 V D 0.594 Pathogenic PMS2 P54278 V214E 214 V E 0.116 Neutral PMS2 P54278 V214F 214 V F 0.45 Neutral PMS2 P54278 V214G 214 V G 0.624 Pathogenic PMS2 P54278 V214H 214 V H 0.164 Neutral PMS2 P54278 V214I 214 V I 0.05 Neutral PMS2 P54278 V214K 214 V K 0.182 Neutral PMS2 P54278 V214L 214 V L 0.042 Neutral PMS2 P54278 V214M 214 V M 0.1 Neutral PMS2 P54278 V214N 214 V N 0.63 Pathogenic PMS2 P54278 V214P 214 V P 0.862 Pathogenic PMS2 P54278 V214Q 214 V Q 0.126 Neutral PMS2 P54278 V214R 214 V R 0.522 Pathogenic PMS2 P54278 V214S 214 V S 0.058 Neutral PMS2 P54278 V214T 214 V T 0.172 Neutral PMS2 P54278 V214W 214 V W 0.838 Pathogenic PMS2 P54278 V214Y 214 V Y 0.828 Pathogenic PMS2 P54278 V215A 215 V A 0.128 Neutral PMS2 P54278 V215C 215 V C 0.71 Pathogenic PMS2 P54278 V215D 215 V D 0.864 Pathogenic PMS2 P54278 V215E 215 V E 0.978 Pathogenic PMS2 P54278 V215F 215 V F 0.506 Pathogenic PMS2 P54278 V215G 215 V G 0.906 Pathogenic PMS2 P54278 V215H 215 V H 0.812 Pathogenic PMS2 P54278 V215I 215 V I 0.162 Neutral PMS2 P54278 V215K 215 V K 0.976 Pathogenic PMS2 P54278 V215L 215 V L 0.174 Neutral PMS2 P54278 V215M 215 V M 0.222 Neutral PMS2 P54278 V215N 215 V N 0.932 Pathogenic PMS2 P54278 V215P 215 V P 0.976 Pathogenic PMS2 P54278 V215Q 215 V Q 0.99 Pathogenic PMS2 P54278 V215R 215 V R 0.958 Pathogenic PMS2 P54278 V215S 215 V S 0.744 Pathogenic PMS2 P54278 V215T 215 V T 0.746 Pathogenic PMS2 P54278 V215W 215 V W 0.902 Pathogenic PMS2 P54278 V215Y 215 V Y 0.928 Pathogenic PMS2 P54278 C216A 216 C A 0.014 Neutral PMS2 P54278 C216D 216 C D 0.186 Neutral PMS2 P54278 C216E 216 C E 0.09 Neutral PMS2 P54278 C216F 216 C F 0.756 Pathogenic PMS2 P54278 C216G 216 C G 0.02 Neutral PMS2 P54278 C216H 216 C H 0.54 Pathogenic PMS2 P54278 C216I 216 C I 0.09 Neutral PMS2 P54278 C216K 216 C K 0.04 Neutral PMS2 P54278 C216L 216 C L 0.05 Neutral PMS2 P54278 C216M 216 C M 0.22 Neutral PMS2 P54278 C216N 216 C N 0.002 Neutral PMS2 P54278 C216P 216 C P 0.55 Pathogenic PMS2 P54278 C216Q 216 C Q 0.016 Neutral PMS2 P54278 C216R 216 C R 0.398 Neutral PMS2 P54278 C216S 216 C S 0.026 Neutral PMS2 P54278 C216T 216 C T 0.006 Neutral PMS2 P54278 C216V 216 C V 0.03 Neutral PMS2 P54278 C216W 216 C W 0.826 Pathogenic PMS2 P54278 C216Y 216 C Y 0.794 Pathogenic PMS2 P54278 T217A 217 T A 0.13 Neutral PMS2 P54278 T217C 217 T C 0.208 Neutral PMS2 P54278 T217D 217 T D 0.452 Neutral PMS2 P54278 T217E 217 T E 0.472 Neutral PMS2 P54278 T217F 217 T F 0.908 Pathogenic PMS2 P54278 T217G 217 T G 0.096 Neutral PMS2 P54278 T217H 217 T H 0.834 Pathogenic PMS2 P54278 T217I 217 T I 0.872 Pathogenic PMS2 P54278 T217K 217 T K 0.606 Pathogenic PMS2 P54278 T217L 217 T L 0.858 Pathogenic PMS2 P54278 T217M 217 T M 0.702 Pathogenic PMS2 P54278 T217N 217 T N 0.15 Neutral PMS2 P54278 T217P 217 T P 0.9 Pathogenic PMS2 P54278 T217Q 217 T Q 0.75 Pathogenic PMS2 P54278 T217R 217 T R 0.954 Pathogenic PMS2 P54278 T217S 217 T S 0.064 Neutral PMS2 P54278 T217V 217 T V 0.712 Pathogenic PMS2 P54278 T217W 217 T W 0.988 Pathogenic PMS2 P54278 T217Y 217 T Y 0.916 Pathogenic PMS2 P54278 G218A 218 G A 0.006 Neutral PMS2 P54278 G218C 218 G C 0.364 Neutral PMS2 P54278 G218D 218 G D 0.21 Neutral PMS2 P54278 G218E 218 G E 0.288 Neutral PMS2 P54278 G218F 218 G F 0.578 Pathogenic PMS2 P54278 G218H 218 G H 0.398 Neutral PMS2 P54278 G218I 218 G I 0.516 Pathogenic PMS2 P54278 G218K 218 G K 0.39 Neutral PMS2 P54278 G218L 218 G L 0.442 Neutral PMS2 P54278 G218M 218 G M 0.392 Neutral PMS2 P54278 G218N 218 G N 0.26 Neutral PMS2 P54278 G218P 218 G P 0.462 Neutral PMS2 P54278 G218Q 218 G Q 0.302 Neutral PMS2 P54278 G218R 218 G R 0.416 Neutral PMS2 P54278 G218S 218 G S 0.03 Neutral PMS2 P54278 G218T 218 G T 0.358 Neutral PMS2 P54278 G218V 218 G V 0.428 Neutral PMS2 P54278 G218W 218 G W 0.76 Pathogenic PMS2 P54278 G218Y 218 G Y 0.746 Pathogenic PMS2 P54278 G219A 219 G A 0.41 Neutral PMS2 P54278 G219C 219 G C 0.658 Pathogenic PMS2 P54278 G219D 219 G D 0.702 Pathogenic PMS2 P54278 G219E 219 G E 0.802 Pathogenic PMS2 P54278 G219F 219 G F 0.988 Pathogenic PMS2 P54278 G219H 219 G H 0.992 Pathogenic PMS2 P54278 G219I 219 G I 0.978 Pathogenic PMS2 P54278 G219K 219 G K 0.896 Pathogenic PMS2 P54278 G219L 219 G L 0.988 Pathogenic PMS2 P54278 G219M 219 G M 0.994 Pathogenic PMS2 P54278 G219N 219 G N 0.494 Neutral PMS2 P54278 G219P 219 G P 0.732 Pathogenic PMS2 P54278 G219Q 219 G Q 0.966 Pathogenic PMS2 P54278 G219R 219 G R 1 Pathogenic PMS2 P54278 G219S 219 G S 0.31 Neutral PMS2 P54278 G219T 219 G T 0.926 Pathogenic PMS2 P54278 G219V 219 G V 0.99 Pathogenic PMS2 P54278 G219W 219 G W 0.984 Pathogenic PMS2 P54278 G219Y 219 G Y 0.914 Pathogenic PMS2 P54278 S22A 22 S A 0.076 Neutral PMS2 P54278 S22C 22 S C 0.402 Neutral PMS2 P54278 S22D 22 S D 0.082 Neutral PMS2 P54278 S22E 22 S E 0.424 Neutral PMS2 P54278 S22F 22 S F 0.822 Pathogenic PMS2 P54278 S22G 22 S G 0.278 Neutral PMS2 P54278 S22H 22 S H 0.658 Pathogenic PMS2 P54278 S22I 22 S I 0.336 Neutral PMS2 P54278 S22K 22 S K 0.608 Pathogenic PMS2 P54278 S22L 22 S L 0.542 Pathogenic PMS2 P54278 S22M 22 S M 0.932 Pathogenic PMS2 P54278 S22N 22 S N 0.056 Neutral PMS2 P54278 S22P 22 S P 0.382 Neutral PMS2 P54278 S22Q 22 S Q 0.528 Pathogenic PMS2 P54278 S22R 22 S R 0.442 Neutral PMS2 P54278 S22T 22 S T 0.056 Neutral PMS2 P54278 S22V 22 S V 0.092 Neutral PMS2 P54278 S22W 22 S W 0.928 Pathogenic PMS2 P54278 S22Y 22 S Y 0.902 Pathogenic PMS2 P54278 S220A 220 S A 0.018 Neutral PMS2 P54278 S220C 220 S C 0.04 Neutral PMS2 P54278 S220D 220 S D 0.044 Neutral PMS2 P54278 S220E 220 S E 0.408 Neutral PMS2 P54278 S220F 220 S F 0.442 Neutral PMS2 P54278 S220G 220 S G 0.008 Neutral PMS2 P54278 S220H 220 S H 0.348 Neutral PMS2 P54278 S220I 220 S I 0.238 Neutral PMS2 P54278 S220K 220 S K 0.306 Neutral PMS2 P54278 S220L 220 S L 0.062 Neutral PMS2 P54278 S220M 220 S M 0.464 Neutral PMS2 P54278 S220N 220 S N 0.014 Neutral PMS2 P54278 S220P 220 S P 0.292 Neutral PMS2 P54278 S220Q 220 S Q 0.402 Neutral PMS2 P54278 S220R 220 S R 0.314 Neutral PMS2 P54278 S220T 220 S T 0.028 Neutral PMS2 P54278 S220V 220 S V 0.054 Neutral PMS2 P54278 S220W 220 S W 0.86 Pathogenic PMS2 P54278 S220Y 220 S Y 0.572 Pathogenic PMS2 P54278 P221A 221 P A 0.08 Neutral PMS2 P54278 P221C 221 P C 0.096 Neutral PMS2 P54278 P221D 221 P D 0.046 Neutral PMS2 P54278 P221E 221 P E 0.188 Neutral PMS2 P54278 P221F 221 P F 0.974 Pathogenic PMS2 P54278 P221G 221 P G 0.052 Neutral PMS2 P54278 P221H 221 P H 0.78 Pathogenic PMS2 P54278 P221I 221 P I 0.228 Neutral PMS2 P54278 P221K 221 P K 0.132 Neutral PMS2 P54278 P221L 221 P L 0.144 Neutral PMS2 P54278 P221M 221 P M 0.722 Pathogenic PMS2 P54278 P221N 221 P N 0.038 Neutral PMS2 P54278 P221Q 221 P Q 0.138 Neutral PMS2 P54278 P221R 221 P R 0.596 Pathogenic PMS2 P54278 P221S 221 P S 0.154 Neutral PMS2 P54278 P221T 221 P T 0.046 Neutral PMS2 P54278 P221V 221 P V 0.552 Pathogenic PMS2 P54278 P221W 221 P W 0.924 Pathogenic PMS2 P54278 P221Y 221 P Y 0.906 Pathogenic PMS2 P54278 S222A 222 S A 0.046 Neutral PMS2 P54278 S222C 222 S C 0.334 Neutral PMS2 P54278 S222D 222 S D 0.034 Neutral PMS2 P54278 S222E 222 S E 0.358 Neutral PMS2 P54278 S222F 222 S F 0.76 Pathogenic PMS2 P54278 S222G 222 S G 0.028 Neutral PMS2 P54278 S222H 222 S H 0.512 Pathogenic PMS2 P54278 S222I 222 S I 0.46 Neutral PMS2 P54278 S222K 222 S K 0.378 Neutral PMS2 P54278 S222L 222 S L 0.166 Neutral PMS2 P54278 S222M 222 S M 0.894 Pathogenic PMS2 P54278 S222N 222 S N 0.036 Neutral PMS2 P54278 S222P 222 S P 0.442 Neutral PMS2 P54278 S222Q 222 S Q 0.418 Neutral PMS2 P54278 S222R 222 S R 0.388 Neutral PMS2 P54278 S222T 222 S T 0.04 Neutral PMS2 P54278 S222V 222 S V 0.722 Pathogenic PMS2 P54278 S222W 222 S W 0.906 Pathogenic PMS2 P54278 S222Y 222 S Y 0.65 Pathogenic PMS2 P54278 I223A 223 I A 0.124 Neutral PMS2 P54278 I223C 223 I C 0.156 Neutral PMS2 P54278 I223D 223 I D 0.238 Neutral PMS2 P54278 I223E 223 I E 0.22 Neutral PMS2 P54278 I223F 223 I F 0.23 Neutral PMS2 P54278 I223G 223 I G 0.298 Neutral PMS2 P54278 I223H 223 I H 0.156 Neutral PMS2 P54278 I223K 223 I K 0.226 Neutral PMS2 P54278 I223L 223 I L 0.004 Neutral PMS2 P54278 I223M 223 I M 0.026 Neutral PMS2 P54278 I223N 223 I N 0.286 Neutral PMS2 P54278 I223P 223 I P 0.268 Neutral PMS2 P54278 I223Q 223 I Q 0.276 Neutral PMS2 P54278 I223R 223 I R 0.542 Pathogenic PMS2 P54278 I223S 223 I S 0.238 Neutral PMS2 P54278 I223T 223 I T 0.01 Neutral PMS2 P54278 I223V 223 I V 0.002 Neutral PMS2 P54278 I223W 223 I W 0.618 Pathogenic PMS2 P54278 I223Y 223 I Y 0.48 Neutral PMS2 P54278 K224A 224 K A 0.212 Neutral PMS2 P54278 K224C 224 K C 0.172 Neutral PMS2 P54278 K224D 224 K D 0.186 Neutral PMS2 P54278 K224E 224 K E 0.054 Neutral PMS2 P54278 K224F 224 K F 0.77 Pathogenic PMS2 P54278 K224G 224 K G 0.332 Neutral PMS2 P54278 K224H 224 K H 0.274 Neutral PMS2 P54278 K224I 224 K I 0.486 Neutral PMS2 P54278 K224L 224 K L 0.096 Neutral PMS2 P54278 K224M 224 K M 0.302 Neutral PMS2 P54278 K224N 224 K N 0.278 Neutral PMS2 P54278 K224P 224 K P 0.776 Pathogenic PMS2 P54278 K224Q 224 K Q 0.204 Neutral PMS2 P54278 K224R 224 K R 0.022 Neutral PMS2 P54278 K224S 224 K S 0.258 Neutral PMS2 P54278 K224T 224 K T 0.452 Neutral PMS2 P54278 K224V 224 K V 0.726 Pathogenic PMS2 P54278 K224W 224 K W 0.95 Pathogenic PMS2 P54278 K224Y 224 K Y 0.886 Pathogenic PMS2 P54278 E225A 225 E A 0.206 Neutral PMS2 P54278 E225C 225 E C 0.43 Neutral PMS2 P54278 E225D 225 E D 0.016 Neutral PMS2 P54278 E225F 225 E F 0.812 Pathogenic PMS2 P54278 E225G 225 E G 0.168 Neutral PMS2 P54278 E225H 225 E H 0.56 Pathogenic PMS2 P54278 E225I 225 E I 0.87 Pathogenic PMS2 P54278 E225K 225 E K 0.676 Pathogenic PMS2 P54278 E225L 225 E L 0.848 Pathogenic PMS2 P54278 E225M 225 E M 0.662 Pathogenic PMS2 P54278 E225N 225 E N 0.052 Neutral PMS2 P54278 E225P 225 E P 0.86 Pathogenic PMS2 P54278 E225Q 225 E Q 0.166 Neutral PMS2 P54278 E225R 225 E R 0.4 Neutral PMS2 P54278 E225S 225 E S 0.036 Neutral PMS2 P54278 E225T 225 E T 0.576 Pathogenic PMS2 P54278 E225V 225 E V 0.816 Pathogenic PMS2 P54278 E225W 225 E W 0.94 Pathogenic PMS2 P54278 E225Y 225 E Y 0.866 Pathogenic PMS2 P54278 N226A 226 N A 0.348 Neutral PMS2 P54278 N226C 226 N C 0.542 Pathogenic PMS2 P54278 N226D 226 N D 0.576 Pathogenic PMS2 P54278 N226E 226 N E 0.528 Pathogenic PMS2 P54278 N226F 226 N F 0.924 Pathogenic PMS2 P54278 N226G 226 N G 0.612 Pathogenic PMS2 P54278 N226H 226 N H 0.768 Pathogenic PMS2 P54278 N226I 226 N I 0.438 Neutral PMS2 P54278 N226K 226 N K 0.82 Pathogenic PMS2 P54278 N226L 226 N L 0.886 Pathogenic PMS2 P54278 N226M 226 N M 0.872 Pathogenic PMS2 P54278 N226P 226 N P 0.76 Pathogenic PMS2 P54278 N226Q 226 N Q 0.654 Pathogenic PMS2 P54278 N226R 226 N R 0.62 Pathogenic PMS2 P54278 N226S 226 N S 0.05 Neutral PMS2 P54278 N226T 226 N T 0.246 Neutral PMS2 P54278 N226V 226 N V 0.15 Neutral PMS2 P54278 N226W 226 N W 0.946 Pathogenic PMS2 P54278 N226Y 226 N Y 0.938 Pathogenic PMS2 P54278 I227A 227 I A 0.27 Neutral PMS2 P54278 I227C 227 I C 0.416 Neutral PMS2 P54278 I227D 227 I D 0.616 Pathogenic PMS2 P54278 I227E 227 I E 0.598 Pathogenic PMS2 P54278 I227F 227 I F 0.55 Pathogenic PMS2 P54278 I227G 227 I G 0.5 Pathogenic PMS2 P54278 I227H 227 I H 0.486 Neutral PMS2 P54278 I227K 227 I K 0.612 Pathogenic PMS2 P54278 I227L 227 I L 0.128 Neutral PMS2 P54278 I227M 227 I M 0.37 Neutral PMS2 P54278 I227N 227 I N 0.66 Pathogenic PMS2 P54278 I227P 227 I P 0.764 Pathogenic PMS2 P54278 I227Q 227 I Q 0.634 Pathogenic PMS2 P54278 I227R 227 I R 0.83 Pathogenic PMS2 P54278 I227S 227 I S 0.43 Neutral PMS2 P54278 I227T 227 I T 0.33 Neutral PMS2 P54278 I227V 227 I V 0.002 Neutral PMS2 P54278 I227W 227 I W 0.892 Pathogenic PMS2 P54278 I227Y 227 I Y 0.832 Pathogenic PMS2 P54278 G228A 228 G A 0.048 Neutral PMS2 P54278 G228C 228 G C 0.594 Pathogenic PMS2 P54278 G228D 228 G D 0.744 Pathogenic PMS2 P54278 G228E 228 G E 0.5 Pathogenic PMS2 P54278 G228F 228 G F 0.95 Pathogenic PMS2 P54278 G228H 228 G H 0.564 Pathogenic PMS2 P54278 G228I 228 G I 0.656 Pathogenic PMS2 P54278 G228K 228 G K 0.558 Pathogenic PMS2 P54278 G228L 228 G L 0.926 Pathogenic PMS2 P54278 G228M 228 G M 0.952 Pathogenic PMS2 P54278 G228N 228 G N 0.418 Neutral PMS2 P54278 G228P 228 G P 0.914 Pathogenic PMS2 P54278 G228Q 228 G Q 0.606 Pathogenic PMS2 P54278 G228R 228 G R 0.606 Pathogenic PMS2 P54278 G228S 228 G S 0.062 Neutral PMS2 P54278 G228T 228 G T 0.53 Pathogenic PMS2 P54278 G228V 228 G V 0.574 Pathogenic PMS2 P54278 G228W 228 G W 0.94 Pathogenic PMS2 P54278 G228Y 228 G Y 0.922 Pathogenic PMS2 P54278 S229A 229 S A 0.036 Neutral PMS2 P54278 S229C 229 S C 0.04 Neutral PMS2 P54278 S229D 229 S D 0.106 Neutral PMS2 P54278 S229E 229 S E 0.4 Neutral PMS2 P54278 S229F 229 S F 0.772 Pathogenic PMS2 P54278 S229G 229 S G 0.276 Neutral PMS2 P54278 S229H 229 S H 0.522 Pathogenic PMS2 P54278 S229I 229 S I 0.278 Neutral PMS2 P54278 S229K 229 S K 0.574 Pathogenic PMS2 P54278 S229L 229 S L 0.114 Neutral PMS2 P54278 S229M 229 S M 0.872 Pathogenic PMS2 P54278 S229N 229 S N 0.026 Neutral PMS2 P54278 S229P 229 S P 0.49 Neutral PMS2 P54278 S229Q 229 S Q 0.402 Neutral PMS2 P54278 S229R 229 S R 0.706 Pathogenic PMS2 P54278 S229T 229 S T 0.04 Neutral PMS2 P54278 S229V 229 S V 0.064 Neutral PMS2 P54278 S229W 229 S W 0.638 Pathogenic PMS2 P54278 S229Y 229 S Y 0.89 Pathogenic PMS2 P54278 V23A 23 V A 0.022 Neutral PMS2 P54278 V23C 23 V C 0.05 Neutral PMS2 P54278 V23D 23 V D 0.066 Neutral PMS2 P54278 V23E 23 V E 0.158 Neutral PMS2 P54278 V23F 23 V F 0.624 Pathogenic PMS2 P54278 V23G 23 V G 0.096 Neutral PMS2 P54278 V23H 23 V H 0.544 Pathogenic PMS2 P54278 V23I 23 V I 0.046 Neutral PMS2 P54278 V23K 23 V K 0.636 Pathogenic PMS2 P54278 V23L 23 V L 0.574 Pathogenic PMS2 P54278 V23M 23 V M 0.5 Pathogenic PMS2 P54278 V23N 23 V N 0.104 Neutral PMS2 P54278 V23P 23 V P 0.374 Neutral PMS2 P54278 V23Q 23 V Q 0.532 Pathogenic PMS2 P54278 V23R 23 V R 0.838 Pathogenic PMS2 P54278 V23S 23 V S 0.052 Neutral PMS2 P54278 V23T 23 V T 0.038 Neutral PMS2 P54278 V23W 23 V W 0.842 Pathogenic PMS2 P54278 V23Y 23 V Y 0.832 Pathogenic PMS2 P54278 V230A 230 V A 0.042 Neutral PMS2 P54278 V230C 230 V C 0.404 Neutral PMS2 P54278 V230D 230 V D 0.612 Pathogenic PMS2 P54278 V230E 230 V E 0.126 Neutral PMS2 P54278 V230F 230 V F 0.622 Pathogenic PMS2 P54278 V230G 230 V G 0.632 Pathogenic PMS2 P54278 V230H 230 V H 0.546 Pathogenic PMS2 P54278 V230I 230 V I 0.062 Neutral PMS2 P54278 V230K 230 V K 0.352 Neutral PMS2 P54278 V230L 230 V L 0.046 Neutral PMS2 P54278 V230M 230 V M 0.076 Neutral PMS2 P54278 V230N 230 V N 0.492 Neutral PMS2 P54278 V230P 230 V P 0.702 Pathogenic PMS2 P54278 V230Q 230 V Q 0.138 Neutral PMS2 P54278 V230R 230 V R 0.838 Pathogenic PMS2 P54278 V230S 230 V S 0.052 Neutral PMS2 P54278 V230T 230 V T 0.022 Neutral PMS2 P54278 V230W 230 V W 0.842 Pathogenic PMS2 P54278 V230Y 230 V Y 0.832 Pathogenic PMS2 P54278 F231A 231 F A 0.496 Neutral PMS2 P54278 F231C 231 F C 0.714 Pathogenic PMS2 P54278 F231D 231 F D 0.79 Pathogenic PMS2 P54278 F231E 231 F E 0.836 Pathogenic PMS2 P54278 F231G 231 F G 0.5 Pathogenic PMS2 P54278 F231H 231 F H 0.748 Pathogenic PMS2 P54278 F231I 231 F I 0.312 Neutral PMS2 P54278 F231K 231 F K 0.816 Pathogenic PMS2 P54278 F231L 231 F L 0.172 Neutral PMS2 P54278 F231M 231 F M 0.216 Neutral PMS2 P54278 F231N 231 F N 0.736 Pathogenic PMS2 P54278 F231P 231 F P 0.944 Pathogenic PMS2 P54278 F231Q 231 F Q 0.748 Pathogenic PMS2 P54278 F231R 231 F R 0.884 Pathogenic PMS2 P54278 F231S 231 F S 0.848 Pathogenic PMS2 P54278 F231T 231 F T 0.544 Pathogenic PMS2 P54278 F231V 231 F V 0.694 Pathogenic PMS2 P54278 F231W 231 F W 0.626 Pathogenic PMS2 P54278 F231Y 231 F Y 0.22 Neutral PMS2 P54278 G232A 232 G A 0.944 Pathogenic PMS2 P54278 G232C 232 G C 0.936 Pathogenic PMS2 P54278 G232D 232 G D 0.576 Pathogenic PMS2 P54278 G232E 232 G E 0.978 Pathogenic PMS2 P54278 G232F 232 G F 0.752 Pathogenic PMS2 P54278 G232H 232 G H 0.87 Pathogenic PMS2 P54278 G232I 232 G I 0.966 Pathogenic PMS2 P54278 G232K 232 G K 0.978 Pathogenic PMS2 P54278 G232L 232 G L 0.976 Pathogenic PMS2 P54278 G232M 232 G M 0.99 Pathogenic PMS2 P54278 G232N 232 G N 0.58 Pathogenic PMS2 P54278 G232P 232 G P 0.936 Pathogenic PMS2 P54278 G232Q 232 G Q 0.988 Pathogenic PMS2 P54278 G232R 232 G R 0.996 Pathogenic PMS2 P54278 G232S 232 G S 0.282 Neutral PMS2 P54278 G232T 232 G T 0.696 Pathogenic PMS2 P54278 G232V 232 G V 0.976 Pathogenic PMS2 P54278 G232W 232 G W 0.97 Pathogenic PMS2 P54278 G232Y 232 G Y 0.932 Pathogenic PMS2 P54278 Q233A 233 Q A 0.1 Neutral PMS2 P54278 Q233C 233 Q C 0.366 Neutral PMS2 P54278 Q233D 233 Q D 0.246 Neutral PMS2 P54278 Q233E 233 Q E 0.302 Neutral PMS2 P54278 Q233F 233 Q F 0.508 Pathogenic PMS2 P54278 Q233G 233 Q G 0.478 Neutral PMS2 P54278 Q233H 233 Q H 0.384 Neutral PMS2 P54278 Q233I 233 Q I 0.296 Neutral PMS2 P54278 Q233K 233 Q K 0.048 Neutral PMS2 P54278 Q233L 233 Q L 0.164 Neutral PMS2 P54278 Q233M 233 Q M 0.058 Neutral PMS2 P54278 Q233N 233 Q N 0.34 Neutral PMS2 P54278 Q233P 233 Q P 0.304 Neutral PMS2 P54278 Q233R 233 Q R 0.086 Neutral PMS2 P54278 Q233S 233 Q S 0.096 Neutral PMS2 P54278 Q233T 233 Q T 0.04 Neutral PMS2 P54278 Q233V 233 Q V 0.074 Neutral PMS2 P54278 Q233W 233 Q W 0.864 Pathogenic PMS2 P54278 Q233Y 233 Q Y 0.808 Pathogenic PMS2 P54278 K234A 234 K A 0.216 Neutral PMS2 P54278 K234C 234 K C 0.17 Neutral PMS2 P54278 K234D 234 K D 0.268 Neutral PMS2 P54278 K234E 234 K E 0.306 Neutral PMS2 P54278 K234F 234 K F 0.802 Pathogenic PMS2 P54278 K234G 234 K G 0.328 Neutral PMS2 P54278 K234H 234 K H 0.332 Neutral PMS2 P54278 K234I 234 K I 0.85 Pathogenic PMS2 P54278 K234L 234 K L 0.814 Pathogenic PMS2 P54278 K234M 234 K M 0.61 Pathogenic PMS2 P54278 K234N 234 K N 0.028 Neutral PMS2 P54278 K234P 234 K P 0.796 Pathogenic PMS2 P54278 K234Q 234 K Q 0.102 Neutral PMS2 P54278 K234R 234 K R 0.034 Neutral PMS2 P54278 K234S 234 K S 0.034 Neutral PMS2 P54278 K234T 234 K T 0.392 Neutral PMS2 P54278 K234V 234 K V 0.744 Pathogenic PMS2 P54278 K234W 234 K W 0.976 Pathogenic PMS2 P54278 K234Y 234 K Y 0.92 Pathogenic PMS2 P54278 Q235A 235 Q A 0.146 Neutral PMS2 P54278 Q235C 235 Q C 0.5 Pathogenic PMS2 P54278 Q235D 235 Q D 0.092 Neutral PMS2 P54278 Q235E 235 Q E 0.046 Neutral PMS2 P54278 Q235F 235 Q F 0.84 Pathogenic PMS2 P54278 Q235G 235 Q G 0.182 Neutral PMS2 P54278 Q235H 235 Q H 0.804 Pathogenic PMS2 P54278 Q235I 235 Q I 0.846 Pathogenic PMS2 P54278 Q235K 235 Q K 0.702 Pathogenic PMS2 P54278 Q235L 235 Q L 0.446 Neutral PMS2 P54278 Q235M 235 Q M 0.088 Neutral PMS2 P54278 Q235N 235 Q N 0.61 Pathogenic PMS2 P54278 Q235P 235 Q P 0.844 Pathogenic PMS2 P54278 Q235R 235 Q R 0.4 Neutral PMS2 P54278 Q235S 235 Q S 0.1 Neutral PMS2 P54278 Q235T 235 Q T 0.028 Neutral PMS2 P54278 Q235V 235 Q V 0.364 Neutral PMS2 P54278 Q235W 235 Q W 0.918 Pathogenic PMS2 P54278 Q235Y 235 Q Y 0.888 Pathogenic PMS2 P54278 L236A 236 L A 0.038 Neutral PMS2 P54278 L236C 236 L C 0.372 Neutral PMS2 P54278 L236D 236 L D 0.648 Pathogenic PMS2 P54278 L236E 236 L E 0.6 Pathogenic PMS2 P54278 L236F 236 L F 0.272 Neutral PMS2 P54278 L236G 236 L G 0.568 Pathogenic PMS2 P54278 L236H 236 L H 0.16 Neutral PMS2 P54278 L236I 236 L I 0.03 Neutral PMS2 P54278 L236K 236 L K 0.054 Neutral PMS2 P54278 L236M 236 L M 0.022 Neutral PMS2 P54278 L236N 236 L N 0.598 Pathogenic PMS2 P54278 L236P 236 L P 0.952 Pathogenic PMS2 P54278 L236Q 236 L Q 0.336 Neutral PMS2 P54278 L236R 236 L R 0.864 Pathogenic PMS2 P54278 L236S 236 L S 0.048 Neutral PMS2 P54278 L236T 236 L T 0.046 Neutral PMS2 P54278 L236V 236 L V 0.006 Neutral PMS2 P54278 L236W 236 L W 0.696 Pathogenic PMS2 P54278 L236Y 236 L Y 0.872 Pathogenic PMS2 P54278 Q237A 237 Q A 0.112 Neutral PMS2 P54278 Q237C 237 Q C 0.414 Neutral PMS2 P54278 Q237D 237 Q D 0.032 Neutral PMS2 P54278 Q237E 237 Q E 0.032 Neutral PMS2 P54278 Q237F 237 Q F 0.776 Pathogenic PMS2 P54278 Q237G 237 Q G 0.368 Neutral PMS2 P54278 Q237H 237 Q H 0.432 Neutral PMS2 P54278 Q237I 237 Q I 0.866 Pathogenic PMS2 P54278 Q237K 237 Q K 0.048 Neutral PMS2 P54278 Q237L 237 Q L 0.194 Neutral PMS2 P54278 Q237M 237 Q M 0.678 Pathogenic PMS2 P54278 Q237N 237 Q N 0.068 Neutral PMS2 P54278 Q237P 237 Q P 0.42 Neutral PMS2 P54278 Q237R 237 Q R 0.372 Neutral PMS2 P54278 Q237S 237 Q S 0.084 Neutral PMS2 P54278 Q237T 237 Q T 0.026 Neutral PMS2 P54278 Q237V 237 Q V 0.428 Neutral PMS2 P54278 Q237W 237 Q W 0.894 Pathogenic PMS2 P54278 Q237Y 237 Q Y 0.656 Pathogenic PMS2 P54278 S238A 238 S A 0.042 Neutral PMS2 P54278 S238C 238 S C 0.05 Neutral PMS2 P54278 S238D 238 S D 0.074 Neutral PMS2 P54278 S238E 238 S E 0.462 Neutral PMS2 P54278 S238F 238 S F 0.684 Pathogenic PMS2 P54278 S238G 238 S G 0.024 Neutral PMS2 P54278 S238H 238 S H 0.674 Pathogenic PMS2 P54278 S238I 238 S I 0.598 Pathogenic PMS2 P54278 S238K 238 S K 0.622 Pathogenic PMS2 P54278 S238L 238 S L 0.528 Pathogenic PMS2 P54278 S238M 238 S M 0.976 Pathogenic PMS2 P54278 S238N 238 S N 0.05 Neutral PMS2 P54278 S238P 238 S P 0.602 Pathogenic PMS2 P54278 S238Q 238 S Q 0.488 Neutral PMS2 P54278 S238R 238 S R 0.586 Pathogenic PMS2 P54278 S238T 238 S T 0.078 Neutral PMS2 P54278 S238V 238 S V 0.13 Neutral PMS2 P54278 S238W 238 S W 0.952 Pathogenic PMS2 P54278 S238Y 238 S Y 0.932 Pathogenic PMS2 P54278 L239A 239 L A 0.706 Pathogenic PMS2 P54278 L239C 239 L C 0.81 Pathogenic PMS2 P54278 L239D 239 L D 0.524 Pathogenic PMS2 P54278 L239E 239 L E 0.292 Neutral PMS2 P54278 L239F 239 L F 0.834 Pathogenic PMS2 P54278 L239G 239 L G 0.844 Pathogenic PMS2 P54278 L239H 239 L H 0.442 Neutral PMS2 P54278 L239I 239 L I 0.246 Neutral PMS2 P54278 L239K 239 L K 0.696 Pathogenic PMS2 P54278 L239M 239 L M 0.144 Neutral PMS2 P54278 L239N 239 L N 0.778 Pathogenic PMS2 P54278 L239P 239 L P 0.97 Pathogenic PMS2 P54278 L239Q 239 L Q 0.742 Pathogenic PMS2 P54278 L239R 239 L R 0.974 Pathogenic PMS2 P54278 L239S 239 L S 0.322 Neutral PMS2 P54278 L239T 239 L T 0.586 Pathogenic PMS2 P54278 L239V 239 L V 0.052 Neutral PMS2 P54278 L239W 239 L W 0.836 Pathogenic PMS2 P54278 L239Y 239 L Y 0.86 Pathogenic PMS2 P54278 H24A 24 H A 0.112 Neutral PMS2 P54278 H24C 24 H C 0.298 Neutral PMS2 P54278 H24D 24 H D 0.102 Neutral PMS2 P54278 H24E 24 H E 0.01 Neutral PMS2 P54278 H24F 24 H F 0.724 Pathogenic PMS2 P54278 H24G 24 H G 0.266 Neutral PMS2 P54278 H24I 24 H I 0.74 Pathogenic PMS2 P54278 H24K 24 H K 0.03 Neutral PMS2 P54278 H24L 24 H L 0.604 Pathogenic PMS2 P54278 H24M 24 H M 0.246 Neutral PMS2 P54278 H24N 24 H N 0.02 Neutral PMS2 P54278 H24P 24 H P 0.358 Neutral PMS2 P54278 H24Q 24 H Q 0.098 Neutral PMS2 P54278 H24R 24 H R 0.02 Neutral PMS2 P54278 H24S 24 H S 0.026 Neutral PMS2 P54278 H24T 24 H T 0.032 Neutral PMS2 P54278 H24V 24 H V 0.48 Neutral PMS2 P54278 H24W 24 H W 0.924 Pathogenic PMS2 P54278 H24Y 24 H Y 0.754 Pathogenic PMS2 P54278 I240A 240 I A 0.282 Neutral PMS2 P54278 I240C 240 I C 0.434 Neutral PMS2 P54278 I240D 240 I D 0.092 Neutral PMS2 P54278 I240E 240 I E 0.086 Neutral PMS2 P54278 I240F 240 I F 0.67 Pathogenic PMS2 P54278 I240G 240 I G 0.588 Pathogenic PMS2 P54278 I240H 240 I H 0.514 Pathogenic PMS2 P54278 I240K 240 I K 0.096 Neutral PMS2 P54278 I240L 240 I L 0.008 Neutral PMS2 P54278 I240M 240 I M 0.032 Neutral PMS2 P54278 I240N 240 I N 0.654 Pathogenic PMS2 P54278 I240P 240 I P 0.712 Pathogenic PMS2 P54278 I240Q 240 I Q 0.146 Neutral PMS2 P54278 I240R 240 I R 0.812 Pathogenic PMS2 P54278 I240S 240 I S 0.388 Neutral PMS2 P54278 I240T 240 I T 0.134 Neutral PMS2 P54278 I240V 240 I V 0.006 Neutral PMS2 P54278 I240W 240 I W 0.856 Pathogenic PMS2 P54278 I240Y 240 I Y 0.848 Pathogenic PMS2 P54278 P241A 241 P A 0.07 Neutral PMS2 P54278 P241C 241 P C 0.122 Neutral PMS2 P54278 P241D 241 P D 0.038 Neutral PMS2 P54278 P241E 241 P E 0.138 Neutral PMS2 P54278 P241F 241 P F 0.62 Pathogenic PMS2 P54278 P241G 241 P G 0.08 Neutral PMS2 P54278 P241H 241 P H 0.558 Pathogenic PMS2 P54278 P241I 241 P I 0.666 Pathogenic PMS2 P54278 P241K 241 P K 0.128 Neutral PMS2 P54278 P241L 241 P L 0.628 Pathogenic PMS2 P54278 P241M 241 P M 0.61 Pathogenic PMS2 P54278 P241N 241 P N 0.102 Neutral PMS2 P54278 P241Q 241 P Q 0.546 Pathogenic PMS2 P54278 P241R 241 P R 0.866 Pathogenic PMS2 P54278 P241S 241 P S 0.024 Neutral PMS2 P54278 P241T 241 P T 0.22 Neutral PMS2 P54278 P241V 241 P V 0.078 Neutral PMS2 P54278 P241W 241 P W 0.924 Pathogenic PMS2 P54278 P241Y 241 P Y 0.738 Pathogenic PMS2 P54278 F242A 242 F A 0.234 Neutral PMS2 P54278 F242C 242 F C 0.274 Neutral PMS2 P54278 F242D 242 F D 0.52 Pathogenic PMS2 P54278 F242E 242 F E 0.594 Pathogenic PMS2 P54278 F242G 242 F G 0.398 Neutral PMS2 P54278 F242H 242 F H 0.268 Neutral PMS2 P54278 F242I 242 F I 0.082 Neutral PMS2 P54278 F242K 242 F K 0.548 Pathogenic PMS2 P54278 F242L 242 F L 0.042 Neutral PMS2 P54278 F242M 242 F M 0.05 Neutral PMS2 P54278 F242N 242 F N 0.522 Pathogenic PMS2 P54278 F242P 242 F P 0.678 Pathogenic PMS2 P54278 F242Q 242 F Q 0.55 Pathogenic PMS2 P54278 F242R 242 F R 0.556 Pathogenic PMS2 P54278 F242S 242 F S 0.494 Neutral PMS2 P54278 F242T 242 F T 0.048 Neutral PMS2 P54278 F242V 242 F V 0.024 Neutral PMS2 P54278 F242W 242 F W 0.806 Pathogenic PMS2 P54278 F242Y 242 F Y 0.586 Pathogenic PMS2 P54278 V243A 243 V A 0.024 Neutral PMS2 P54278 V243C 243 V C 0.294 Neutral PMS2 P54278 V243D 243 V D 0.064 Neutral PMS2 P54278 V243E 243 V E 0.094 Neutral PMS2 P54278 V243F 243 V F 0.6 Pathogenic PMS2 P54278 V243G 243 V G 0.582 Pathogenic PMS2 P54278 V243H 243 V H 0.412 Neutral PMS2 P54278 V243I 243 V I 0.022 Neutral PMS2 P54278 V243K 243 V K 0.12 Neutral PMS2 P54278 V243L 243 V L 0.082 Neutral PMS2 P54278 V243M 243 V M 0.164 Neutral PMS2 P54278 V243N 243 V N 0.532 Pathogenic PMS2 P54278 V243P 243 V P 0.658 Pathogenic PMS2 P54278 V243Q 243 V Q 0.098 Neutral PMS2 P54278 V243R 243 V R 0.48 Neutral PMS2 P54278 V243S 243 V S 0.216 Neutral PMS2 P54278 V243T 243 V T 0.134 Neutral PMS2 P54278 V243W 243 V W 0.716 Pathogenic PMS2 P54278 V243Y 243 V Y 0.688 Pathogenic PMS2 P54278 Q244A 244 Q A 0.058 Neutral PMS2 P54278 Q244C 244 Q C 0.158 Neutral PMS2 P54278 Q244D 244 Q D 0.136 Neutral PMS2 P54278 Q244E 244 Q E 0.05 Neutral PMS2 P54278 Q244F 244 Q F 0.61 Pathogenic PMS2 P54278 Q244G 244 Q G 0.056 Neutral PMS2 P54278 Q244H 244 Q H 0.51 Pathogenic PMS2 P54278 Q244I 244 Q I 0.612 Pathogenic PMS2 P54278 Q244K 244 Q K 0.032 Neutral PMS2 P54278 Q244L 244 Q L 0.144 Neutral PMS2 P54278 Q244M 244 Q M 0.194 Neutral PMS2 P54278 Q244N 244 Q N 0.054 Neutral PMS2 P54278 Q244P 244 Q P 0.378 Neutral PMS2 P54278 Q244R 244 Q R 0.01 Neutral PMS2 P54278 Q244S 244 Q S 0.06 Neutral PMS2 P54278 Q244T 244 Q T 0.006 Neutral PMS2 P54278 Q244V 244 Q V 0.496 Neutral PMS2 P54278 Q244W 244 Q W 0.758 Pathogenic PMS2 P54278 Q244Y 244 Q Y 0.668 Pathogenic PMS2 P54278 L245A 245 L A 0.012 Neutral PMS2 P54278 L245C 245 L C 0.076 Neutral PMS2 P54278 L245D 245 L D 0.07 Neutral PMS2 P54278 L245E 245 L E 0.04 Neutral PMS2 P54278 L245F 245 L F 0.168 Neutral PMS2 P54278 L245G 245 L G 0.26 Neutral PMS2 P54278 L245H 245 L H 0.07 Neutral PMS2 P54278 L245I 245 L I 0.004 Neutral PMS2 P54278 L245K 245 L K 0.1 Neutral PMS2 P54278 L245M 245 L M 0.01 Neutral PMS2 P54278 L245N 245 L N 0.224 Neutral PMS2 P54278 L245P 245 L P 0.334 Neutral PMS2 P54278 L245Q 245 L Q 0.078 Neutral PMS2 P54278 L245R 245 L R 0.362 Neutral PMS2 P54278 L245S 245 L S 0.26 Neutral PMS2 P54278 L245T 245 L T 0.04 Neutral PMS2 P54278 L245V 245 L V 0.002 Neutral PMS2 P54278 L245W 245 L W 0.524 Pathogenic PMS2 P54278 L245Y 245 L Y 0.486 Neutral PMS2 P54278 P246A 246 P A 0.068 Neutral PMS2 P54278 P246C 246 P C 0.106 Neutral PMS2 P54278 P246D 246 P D 0.018 Neutral PMS2 P54278 P246E 246 P E 0.086 Neutral PMS2 P54278 P246F 246 P F 0.528 Pathogenic PMS2 P54278 P246G 246 P G 0.036 Neutral PMS2 P54278 P246H 246 P H 0.488 Neutral PMS2 P54278 P246I 246 P I 0.224 Neutral PMS2 P54278 P246K 246 P K 0.082 Neutral PMS2 P54278 P246L 246 P L 0.054 Neutral PMS2 P54278 P246M 246 P M 0.392 Neutral PMS2 P54278 P246N 246 P N 0.084 Neutral PMS2 P54278 P246Q 246 P Q 0.106 Neutral PMS2 P54278 P246R 246 P R 0.348 Neutral PMS2 P54278 P246S 246 P S 0.012 Neutral PMS2 P54278 P246T 246 P T 0.106 Neutral PMS2 P54278 P246V 246 P V 0.158 Neutral PMS2 P54278 P246W 246 P W 0.624 Pathogenic PMS2 P54278 P246Y 246 P Y 0.556 Pathogenic PMS2 P54278 P247A 247 P A 0.068 Neutral PMS2 P54278 P247C 247 P C 0.24 Neutral PMS2 P54278 P247D 247 P D 0.026 Neutral PMS2 P54278 P247E 247 P E 0.102 Neutral PMS2 P54278 P247F 247 P F 0.384 Neutral PMS2 P54278 P247G 247 P G 0.142 Neutral PMS2 P54278 P247H 247 P H 0.492 Neutral PMS2 P54278 P247I 247 P I 0.088 Neutral PMS2 P54278 P247K 247 P K 0.076 Neutral PMS2 P54278 P247L 247 P L 0.052 Neutral PMS2 P54278 P247M 247 P M 0.384 Neutral PMS2 P54278 P247N 247 P N 0.112 Neutral PMS2 P54278 P247Q 247 P Q 0.102 Neutral PMS2 P54278 P247R 247 P R 0.466 Neutral PMS2 P54278 P247S 247 P S 0.17 Neutral PMS2 P54278 P247T 247 P T 0.194 Neutral PMS2 P54278 P247V 247 P V 0.056 Neutral PMS2 P54278 P247W 247 P W 0.62 Pathogenic PMS2 P54278 P247Y 247 P Y 0.366 Neutral PMS2 P54278 S248A 248 S A 0.014 Neutral PMS2 P54278 S248C 248 S C 0.008 Neutral PMS2 P54278 S248D 248 S D 0.012 Neutral PMS2 P54278 S248E 248 S E 0.232 Neutral PMS2 P54278 S248F 248 S F 0.506 Pathogenic PMS2 P54278 S248G 248 S G 0.006 Neutral PMS2 P54278 S248H 248 S H 0.434 Neutral PMS2 P54278 S248I 248 S I 0.224 Neutral PMS2 P54278 S248K 248 S K 0.248 Neutral PMS2 P54278 S248L 248 S L 0.078 Neutral PMS2 P54278 S248M 248 S M 0.608 Pathogenic PMS2 P54278 S248N 248 S N 0.01 Neutral PMS2 P54278 S248P 248 S P 0.204 Neutral PMS2 P54278 S248Q 248 S Q 0.27 Neutral PMS2 P54278 S248R 248 S R 0.25 Neutral PMS2 P54278 S248T 248 S T 0.026 Neutral PMS2 P54278 S248V 248 S V 0.192 Neutral PMS2 P54278 S248W 248 S W 0.724 Pathogenic PMS2 P54278 S248Y 248 S Y 0.686 Pathogenic PMS2 P54278 D249A 249 D A 0.018 Neutral PMS2 P54278 D249C 249 D C 0.178 Neutral PMS2 P54278 D249E 249 D E 0.012 Neutral PMS2 P54278 D249F 249 D F 0.218 Neutral PMS2 P54278 D249G 249 D G 0.09 Neutral PMS2 P54278 D249H 249 D H 0.186 Neutral PMS2 P54278 D249I 249 D I 0.12 Neutral PMS2 P54278 D249K 249 D K 0.218 Neutral PMS2 P54278 D249L 249 D L 0.036 Neutral PMS2 P54278 D249M 249 D M 0.244 Neutral PMS2 P54278 D249N 249 D N 0.016 Neutral PMS2 P54278 D249P 249 D P 0.088 Neutral PMS2 P54278 D249Q 249 D Q 0.016 Neutral PMS2 P54278 D249R 249 D R 0.282 Neutral PMS2 P54278 D249S 249 D S 0.006 Neutral PMS2 P54278 D249T 249 D T 0.042 Neutral PMS2 P54278 D249V 249 D V 0.07 Neutral PMS2 P54278 D249W 249 D W 0.6 Pathogenic PMS2 P54278 D249Y 249 D Y 0.57 Pathogenic PMS2 P54278 Q25A 25 Q A 0.31 Neutral PMS2 P54278 Q25C 25 Q C 0.442 Neutral PMS2 P54278 Q25D 25 Q D 0.354 Neutral PMS2 P54278 Q25E 25 Q E 0.074 Neutral PMS2 P54278 Q25F 25 Q F 0.786 Pathogenic PMS2 P54278 Q25G 25 Q G 0.484 Neutral PMS2 P54278 Q25H 25 Q H 0.114 Neutral PMS2 P54278 Q25I 25 Q I 0.862 Pathogenic PMS2 P54278 Q25K 25 Q K 0.082 Neutral PMS2 P54278 Q25L 25 Q L 0.212 Neutral PMS2 P54278 Q25M 25 Q M 0.682 Pathogenic PMS2 P54278 Q25N 25 Q N 0.142 Neutral PMS2 P54278 Q25P 25 Q P 0.594 Pathogenic PMS2 P54278 Q25R 25 Q R 0.098 Neutral PMS2 P54278 Q25S 25 Q S 0.136 Neutral PMS2 P54278 Q25T 25 Q T 0.16 Neutral PMS2 P54278 Q25V 25 Q V 0.802 Pathogenic PMS2 P54278 Q25W 25 Q W 0.902 Pathogenic PMS2 P54278 Q25Y 25 Q Y 0.86 Pathogenic PMS2 P54278 S250A 250 S A 0.01 Neutral PMS2 P54278 S250C 250 S C 0.008 Neutral PMS2 P54278 S250D 250 S D 0.002 Neutral PMS2 P54278 S250E 250 S E 0.156 Neutral PMS2 P54278 S250F 250 S F 0.32 Neutral PMS2 P54278 S250G 250 S G 0 Neutral PMS2 P54278 S250H 250 S H 0.276 Neutral PMS2 P54278 S250I 250 S I 0.142 Neutral PMS2 P54278 S250K 250 S K 0.166 Neutral PMS2 P54278 S250L 250 S L 0.044 Neutral PMS2 P54278 S250M 250 S M 0.4 Neutral PMS2 P54278 S250N 250 S N 0 Neutral PMS2 P54278 S250P 250 S P 0.062 Neutral PMS2 P54278 S250Q 250 S Q 0.204 Neutral PMS2 P54278 S250R 250 S R 0.288 Neutral PMS2 P54278 S250T 250 S T 0.02 Neutral PMS2 P54278 S250V 250 S V 0.302 Neutral PMS2 P54278 S250W 250 S W 0.542 Pathogenic PMS2 P54278 S250Y 250 S Y 0.498 Neutral PMS2 P54278 V251A 251 V A 0 Neutral PMS2 P54278 V251C 251 V C 0.104 Neutral PMS2 P54278 V251D 251 V D 0.034 Neutral PMS2 P54278 V251E 251 V E 0.284 Neutral PMS2 P54278 V251F 251 V F 0.256 Neutral PMS2 P54278 V251G 251 V G 0.138 Neutral PMS2 P54278 V251H 251 V H 0.172 Neutral PMS2 P54278 V251I 251 V I 0.008 Neutral PMS2 P54278 V251K 251 V K 0.284 Neutral PMS2 P54278 V251L 251 V L 0 Neutral PMS2 P54278 V251M 251 V M 0.026 Neutral PMS2 P54278 V251N 251 V N 0.214 Neutral PMS2 P54278 V251P 251 V P 0.342 Neutral PMS2 P54278 V251Q 251 V Q 0.144 Neutral PMS2 P54278 V251R 251 V R 0.43 Neutral PMS2 P54278 V251S 251 V S 0.016 Neutral PMS2 P54278 V251T 251 V T 0.008 Neutral PMS2 P54278 V251W 251 V W 0.454 Neutral PMS2 P54278 V251Y 251 V Y 0.468 Neutral PMS2 P54278 C252A 252 C A 0.008 Neutral PMS2 P54278 C252D 252 C D 0.014 Neutral PMS2 P54278 C252E 252 C E 0.036 Neutral PMS2 P54278 C252F 252 C F 0.666 Pathogenic PMS2 P54278 C252G 252 C G 0.238 Neutral PMS2 P54278 C252H 252 C H 0.398 Neutral PMS2 P54278 C252I 252 C I 0.094 Neutral PMS2 P54278 C252K 252 C K 0.044 Neutral PMS2 P54278 C252L 252 C L 0.044 Neutral PMS2 P54278 C252M 252 C M 0.296 Neutral PMS2 P54278 C252N 252 C N 0 Neutral PMS2 P54278 C252P 252 C P 0.436 Neutral PMS2 P54278 C252Q 252 C Q 0.014 Neutral PMS2 P54278 C252R 252 C R 0.328 Neutral PMS2 P54278 C252S 252 C S 0.014 Neutral PMS2 P54278 C252T 252 C T 0 Neutral PMS2 P54278 C252V 252 C V 0.132 Neutral PMS2 P54278 C252W 252 C W 0.74 Pathogenic PMS2 P54278 C252Y 252 C Y 0.708 Pathogenic PMS2 P54278 E253A 253 E A 0.106 Neutral PMS2 P54278 E253C 253 E C 0.128 Neutral PMS2 P54278 E253D 253 E D 0.002 Neutral PMS2 P54278 E253F 253 E F 0.51 Pathogenic PMS2 P54278 E253G 253 E G 0 Neutral PMS2 P54278 E253H 253 E H 0.174 Neutral PMS2 P54278 E253I 253 E I 0.168 Neutral PMS2 P54278 E253K 253 E K 0.32 Neutral PMS2 P54278 E253L 253 E L 0.25 Neutral PMS2 P54278 E253M 253 E M 0.344 Neutral PMS2 P54278 E253N 253 E N 0.002 Neutral PMS2 P54278 E253P 253 E P 0.072 Neutral PMS2 P54278 E253Q 253 E Q 0.042 Neutral PMS2 P54278 E253R 253 E R 0.114 Neutral PMS2 P54278 E253S 253 E S 0.034 Neutral PMS2 P54278 E253T 253 E T 0.014 Neutral PMS2 P54278 E253V 253 E V 0.236 Neutral PMS2 P54278 E253W 253 E W 0.742 Pathogenic PMS2 P54278 E253Y 253 E Y 0.606 Pathogenic PMS2 P54278 E254A 254 E A 0.084 Neutral PMS2 P54278 E254C 254 E C 0.018 Neutral PMS2 P54278 E254D 254 E D 0.002 Neutral PMS2 P54278 E254F 254 E F 0.476 Neutral PMS2 P54278 E254G 254 E G 0 Neutral PMS2 P54278 E254H 254 E H 0.158 Neutral PMS2 P54278 E254I 254 E I 0.334 Neutral PMS2 P54278 E254K 254 E K 0.008 Neutral PMS2 P54278 E254L 254 E L 0.454 Neutral PMS2 P54278 E254M 254 E M 0.278 Neutral PMS2 P54278 E254N 254 E N 0.046 Neutral PMS2 P54278 E254P 254 E P 0.468 Neutral PMS2 P54278 E254Q 254 E Q 0.084 Neutral PMS2 P54278 E254R 254 E R 0.098 Neutral PMS2 P54278 E254S 254 E S 0.016 Neutral PMS2 P54278 E254T 254 E T 0.01 Neutral PMS2 P54278 E254V 254 E V 0.046 Neutral PMS2 P54278 E254W 254 E W 0.694 Pathogenic PMS2 P54278 E254Y 254 E Y 0.578 Pathogenic PMS2 P54278 Y255A 255 Y A 0.046 Neutral PMS2 P54278 Y255C 255 Y C 0.14 Neutral PMS2 P54278 Y255D 255 Y D 0.032 Neutral PMS2 P54278 Y255E 255 Y E 0.196 Neutral PMS2 P54278 Y255F 255 Y F 0.01 Neutral PMS2 P54278 Y255G 255 Y G 0.13 Neutral PMS2 P54278 Y255H 255 Y H 0.064 Neutral PMS2 P54278 Y255I 255 Y I 0.016 Neutral PMS2 P54278 Y255K 255 Y K 0.19 Neutral PMS2 P54278 Y255L 255 Y L 0.012 Neutral PMS2 P54278 Y255M 255 Y M 0.026 Neutral PMS2 P54278 Y255N 255 Y N 0.092 Neutral PMS2 P54278 Y255P 255 Y P 0.078 Neutral PMS2 P54278 Y255Q 255 Y Q 0.148 Neutral PMS2 P54278 Y255R 255 Y R 0.164 Neutral PMS2 P54278 Y255S 255 Y S 0.096 Neutral PMS2 P54278 Y255T 255 Y T 0.078 Neutral PMS2 P54278 Y255V 255 Y V 0.016 Neutral PMS2 P54278 Y255W 255 Y W 0.038 Neutral PMS2 P54278 G256A 256 G A 0.006 Neutral PMS2 P54278 G256C 256 G C 0.276 Neutral PMS2 P54278 G256D 256 G D 0.25 Neutral PMS2 P54278 G256E 256 G E 0.432 Neutral PMS2 P54278 G256F 256 G F 0.578 Pathogenic PMS2 P54278 G256H 256 G H 0.716 Pathogenic PMS2 P54278 G256I 256 G I 0.706 Pathogenic PMS2 P54278 G256K 256 G K 0.64 Pathogenic PMS2 P54278 G256L 256 G L 0.69 Pathogenic PMS2 P54278 G256M 256 G M 0.706 Pathogenic PMS2 P54278 G256N 256 G N 0.246 Neutral PMS2 P54278 G256P 256 G P 0.646 Pathogenic PMS2 P54278 G256Q 256 G Q 0.296 Neutral PMS2 P54278 G256R 256 G R 0.416 Neutral PMS2 P54278 G256S 256 G S 0.03 Neutral PMS2 P54278 G256T 256 G T 0.486 Neutral PMS2 P54278 G256V 256 G V 0.668 Pathogenic PMS2 P54278 G256W 256 G W 0.758 Pathogenic PMS2 P54278 G256Y 256 G Y 0.754 Pathogenic PMS2 P54278 L257A 257 L A 0.074 Neutral PMS2 P54278 L257C 257 L C 0.136 Neutral PMS2 P54278 L257D 257 L D 0.05 Neutral PMS2 P54278 L257E 257 L E 0.04 Neutral PMS2 P54278 L257F 257 L F 0.416 Neutral PMS2 P54278 L257G 257 L G 0.25 Neutral PMS2 P54278 L257H 257 L H 0.128 Neutral PMS2 P54278 L257I 257 L I 0.014 Neutral PMS2 P54278 L257K 257 L K 0.102 Neutral PMS2 P54278 L257M 257 L M 0.192 Neutral PMS2 P54278 L257N 257 L N 0.242 Neutral PMS2 P54278 L257P 257 L P 0.356 Neutral PMS2 P54278 L257Q 257 L Q 0.104 Neutral PMS2 P54278 L257R 257 L R 0.504 Pathogenic PMS2 P54278 L257S 257 L S 0.102 Neutral PMS2 P54278 L257T 257 L T 0.248 Neutral PMS2 P54278 L257V 257 L V 0.184 Neutral PMS2 P54278 L257W 257 L W 0.536 Pathogenic PMS2 P54278 L257Y 257 L Y 0.506 Pathogenic PMS2 P54278 S258A 258 S A 0.012 Neutral PMS2 P54278 S258C 258 S C 0.032 Neutral PMS2 P54278 S258D 258 S D 0.024 Neutral PMS2 P54278 S258E 258 S E 0.114 Neutral PMS2 P54278 S258F 258 S F 0.276 Neutral PMS2 P54278 S258G 258 S G 0.01 Neutral PMS2 P54278 S258H 258 S H 0.186 Neutral PMS2 P54278 S258I 258 S I 0.17 Neutral PMS2 P54278 S258K 258 S K 0.164 Neutral PMS2 P54278 S258L 258 S L 0.042 Neutral PMS2 P54278 S258M 258 S M 0.332 Neutral PMS2 P54278 S258N 258 S N 0 Neutral PMS2 P54278 S258P 258 S P 0.116 Neutral PMS2 P54278 S258Q 258 S Q 0.16 Neutral PMS2 P54278 S258R 258 S R 0.152 Neutral PMS2 P54278 S258T 258 S T 0.11 Neutral PMS2 P54278 S258V 258 S V 0.288 Neutral PMS2 P54278 S258W 258 S W 0.49 Neutral PMS2 P54278 S258Y 258 S Y 0.394 Neutral PMS2 P54278 C259A 259 C A 0.004 Neutral PMS2 P54278 C259D 259 C D 0.01 Neutral PMS2 P54278 C259E 259 C E 0.036 Neutral PMS2 P54278 C259F 259 C F 0.318 Neutral PMS2 P54278 C259G 259 C G 0.004 Neutral PMS2 P54278 C259H 259 C H 0.098 Neutral PMS2 P54278 C259I 259 C I 0.27 Neutral PMS2 P54278 C259K 259 C K 0.184 Neutral PMS2 P54278 C259L 259 C L 0.154 Neutral PMS2 P54278 C259M 259 C M 0.136 Neutral PMS2 P54278 C259N 259 C N 0 Neutral PMS2 P54278 C259P 259 C P 0.026 Neutral PMS2 P54278 C259Q 259 C Q 0.082 Neutral PMS2 P54278 C259R 259 C R 0.194 Neutral PMS2 P54278 C259S 259 C S 0.014 Neutral PMS2 P54278 C259T 259 C T 0 Neutral PMS2 P54278 C259V 259 C V 0.186 Neutral PMS2 P54278 C259W 259 C W 0.458 Neutral PMS2 P54278 C259Y 259 C Y 0.432 Neutral PMS2 P54278 I26A 26 I A 0.116 Neutral PMS2 P54278 I26C 26 I C 0.524 Pathogenic PMS2 P54278 I26D 26 I D 0.23 Neutral PMS2 P54278 I26E 26 I E 0.168 Neutral PMS2 P54278 I26F 26 I F 0.762 Pathogenic PMS2 P54278 I26G 26 I G 0.254 Neutral PMS2 P54278 I26H 26 I H 0.682 Pathogenic PMS2 P54278 I26K 26 I K 0.17 Neutral PMS2 P54278 I26L 26 I L 0.168 Neutral PMS2 P54278 I26M 26 I M 0.476 Neutral PMS2 P54278 I26N 26 I N 0.196 Neutral PMS2 P54278 I26P 26 I P 0.236 Neutral PMS2 P54278 I26Q 26 I Q 0.216 Neutral PMS2 P54278 I26R 26 I R 0.544 Pathogenic PMS2 P54278 I26S 26 I S 0.17 Neutral PMS2 P54278 I26T 26 I T 0.18 Neutral PMS2 P54278 I26V 26 I V 0.496 Neutral PMS2 P54278 I26W 26 I W 0.854 Pathogenic PMS2 P54278 I26Y 26 I Y 0.85 Pathogenic PMS2 P54278 S260A 260 S A 0.01 Neutral PMS2 P54278 S260C 260 S C 0.022 Neutral PMS2 P54278 S260D 260 S D 0.044 Neutral PMS2 P54278 S260E 260 S E 0.12 Neutral PMS2 P54278 S260F 260 S F 0.256 Neutral PMS2 P54278 S260G 260 S G 0.01 Neutral PMS2 P54278 S260H 260 S H 0.242 Neutral PMS2 P54278 S260I 260 S I 0.026 Neutral PMS2 P54278 S260K 260 S K 0.146 Neutral PMS2 P54278 S260L 260 S L 0.026 Neutral PMS2 P54278 S260M 260 S M 0.35 Neutral PMS2 P54278 S260N 260 S N 0.02 Neutral PMS2 P54278 S260P 260 S P 0.098 Neutral PMS2 P54278 S260Q 260 S Q 0.162 Neutral PMS2 P54278 S260R 260 S R 0.252 Neutral PMS2 P54278 S260T 260 S T 0.024 Neutral PMS2 P54278 S260V 260 S V 0.138 Neutral PMS2 P54278 S260W 260 S W 0.502 Pathogenic PMS2 P54278 S260Y 260 S Y 0.458 Neutral PMS2 P54278 D261A 261 D A 0.072 Neutral PMS2 P54278 D261C 261 D C 0.156 Neutral PMS2 P54278 D261E 261 D E 0.018 Neutral PMS2 P54278 D261F 261 D F 0.4 Neutral PMS2 P54278 D261G 261 D G 0.172 Neutral PMS2 P54278 D261H 261 D H 0.164 Neutral PMS2 P54278 D261I 261 D I 0.148 Neutral PMS2 P54278 D261K 261 D K 0.02 Neutral PMS2 P54278 D261L 261 D L 0.272 Neutral PMS2 P54278 D261M 261 D M 0.204 Neutral PMS2 P54278 D261N 261 D N 0 Neutral PMS2 P54278 D261P 261 D P 0.296 Neutral PMS2 P54278 D261Q 261 D Q 0.014 Neutral PMS2 P54278 D261R 261 D R 0.174 Neutral PMS2 P54278 D261S 261 D S 0.012 Neutral PMS2 P54278 D261T 261 D T 0.12 Neutral PMS2 P54278 D261V 261 D V 0.276 Neutral PMS2 P54278 D261W 261 D W 0.474 Neutral PMS2 P54278 D261Y 261 D Y 0.44 Neutral PMS2 P54278 A262C 262 A C 0.182 Neutral PMS2 P54278 A262D 262 A D 0.316 Neutral PMS2 P54278 A262E 262 A E 0.276 Neutral PMS2 P54278 A262F 262 A F 0.34 Neutral PMS2 P54278 A262G 262 A G 0.12 Neutral PMS2 P54278 A262H 262 A H 0.26 Neutral PMS2 P54278 A262I 262 A I 0.334 Neutral PMS2 P54278 A262K 262 A K 0.29 Neutral PMS2 P54278 A262L 262 A L 0.312 Neutral PMS2 P54278 A262M 262 A M 0.242 Neutral PMS2 P54278 A262N 262 A N 0.29 Neutral PMS2 P54278 A262P 262 A P 0.138 Neutral PMS2 P54278 A262Q 262 A Q 0.302 Neutral PMS2 P54278 A262R 262 A R 0.36 Neutral PMS2 P54278 A262S 262 A S 0.008 Neutral PMS2 P54278 A262T 262 A T 0.012 Neutral PMS2 P54278 A262V 262 A V 0.04 Neutral PMS2 P54278 A262W 262 A W 0.504 Pathogenic PMS2 P54278 A262Y 262 A Y 0.5 Pathogenic PMS2 P54278 L263A 263 L A 0.088 Neutral PMS2 P54278 L263C 263 L C 0.094 Neutral PMS2 P54278 L263D 263 L D 0.166 Neutral PMS2 P54278 L263E 263 L E 0.034 Neutral PMS2 P54278 L263F 263 L F 0.226 Neutral PMS2 P54278 L263G 263 L G 0.19 Neutral PMS2 P54278 L263H 263 L H 0.084 Neutral PMS2 P54278 L263I 263 L I 0.004 Neutral PMS2 P54278 L263K 263 L K 0.186 Neutral PMS2 P54278 L263M 263 L M 0.18 Neutral PMS2 P54278 L263N 263 L N 0.03 Neutral PMS2 P54278 L263P 263 L P 0.092 Neutral PMS2 P54278 L263Q 263 L Q 0.064 Neutral PMS2 P54278 L263R 263 L R 0.266 Neutral PMS2 P54278 L263S 263 L S 0.136 Neutral PMS2 P54278 L263T 263 L T 0.098 Neutral PMS2 P54278 L263V 263 L V 0.08 Neutral PMS2 P54278 L263W 263 L W 0.37 Neutral PMS2 P54278 L263Y 263 L Y 0.33 Neutral PMS2 P54278 H264A 264 H A 0.076 Neutral PMS2 P54278 H264C 264 H C 0.042 Neutral PMS2 P54278 H264D 264 H D 0 Neutral PMS2 P54278 H264E 264 H E 0 Neutral PMS2 P54278 H264F 264 H F 0.13 Neutral PMS2 P54278 H264G 264 H G 0.13 Neutral PMS2 P54278 H264I 264 H I 0.258 Neutral PMS2 P54278 H264K 264 H K 0.004 Neutral PMS2 P54278 H264L 264 H L 0.016 Neutral PMS2 P54278 H264M 264 H M 0.108 Neutral PMS2 P54278 H264N 264 H N 0.058 Neutral PMS2 P54278 H264P 264 H P 0.026 Neutral PMS2 P54278 H264Q 264 H Q 0.006 Neutral PMS2 P54278 H264R 264 H R 0 Neutral PMS2 P54278 H264S 264 H S 0.014 Neutral PMS2 P54278 H264T 264 H T 0.006 Neutral PMS2 P54278 H264V 264 H V 0.064 Neutral PMS2 P54278 H264W 264 H W 0.398 Neutral PMS2 P54278 H264Y 264 H Y 0.076 Neutral PMS2 P54278 N265A 265 N A 0.004 Neutral PMS2 P54278 N265C 265 N C 0.018 Neutral PMS2 P54278 N265D 265 N D 0.008 Neutral PMS2 P54278 N265E 265 N E 0.016 Neutral PMS2 P54278 N265F 265 N F 0.444 Neutral PMS2 P54278 N265G 265 N G 0.044 Neutral PMS2 P54278 N265H 265 N H 0.134 Neutral PMS2 P54278 N265I 265 N I 0.346 Neutral PMS2 P54278 N265K 265 N K 0.038 Neutral PMS2 P54278 N265L 265 N L 0.112 Neutral PMS2 P54278 N265M 265 N M 0.228 Neutral PMS2 P54278 N265P 265 N P 0.25 Neutral PMS2 P54278 N265Q 265 N Q 0.014 Neutral PMS2 P54278 N265R 265 N R 0.142 Neutral PMS2 P54278 N265S 265 N S 0 Neutral PMS2 P54278 N265T 265 N T 0.006 Neutral PMS2 P54278 N265V 265 N V 0.288 Neutral PMS2 P54278 N265W 265 N W 0.472 Neutral PMS2 P54278 N265Y 265 N Y 0.42 Neutral PMS2 P54278 L266A 266 L A 0.014 Neutral PMS2 P54278 L266C 266 L C 0.07 Neutral PMS2 P54278 L266D 266 L D 0.054 Neutral PMS2 P54278 L266E 266 L E 0.056 Neutral PMS2 P54278 L266F 266 L F 0.408 Neutral PMS2 P54278 L266G 266 L G 0.166 Neutral PMS2 P54278 L266H 266 L H 0.018 Neutral PMS2 P54278 L266I 266 L I 0.008 Neutral PMS2 P54278 L266K 266 L K 0.102 Neutral PMS2 P54278 L266M 266 L M 0.186 Neutral PMS2 P54278 L266N 266 L N 0.216 Neutral PMS2 P54278 L266P 266 L P 0.11 Neutral PMS2 P54278 L266Q 266 L Q 0.024 Neutral PMS2 P54278 L266R 266 L R 0.35 Neutral PMS2 P54278 L266S 266 L S 0.02 Neutral PMS2 P54278 L266T 266 L T 0.022 Neutral PMS2 P54278 L266V 266 L V 0.176 Neutral PMS2 P54278 L266W 266 L W 0.526 Pathogenic PMS2 P54278 L266Y 266 L Y 0.488 Neutral PMS2 P54278 F267A 267 F A 0.174 Neutral PMS2 P54278 F267C 267 F C 0.144 Neutral PMS2 P54278 F267D 267 F D 0.36 Neutral PMS2 P54278 F267E 267 F E 0.346 Neutral PMS2 P54278 F267G 267 F G 0.264 Neutral PMS2 P54278 F267H 267 F H 0.134 Neutral PMS2 P54278 F267I 267 F I 0.006 Neutral PMS2 P54278 F267K 267 F K 0.332 Neutral PMS2 P54278 F267L 267 F L 0.124 Neutral PMS2 P54278 F267M 267 F M 0.038 Neutral PMS2 P54278 F267N 267 F N 0.322 Neutral PMS2 P54278 F267P 267 F P 0.344 Neutral PMS2 P54278 F267Q 267 F Q 0.316 Neutral PMS2 P54278 F267R 267 F R 0.158 Neutral PMS2 P54278 F267S 267 F S 0.364 Neutral PMS2 P54278 F267T 267 F T 0.402 Neutral PMS2 P54278 F267V 267 F V 0.014 Neutral PMS2 P54278 F267W 267 F W 0.56 Pathogenic PMS2 P54278 F267Y 267 F Y 0.018 Neutral PMS2 P54278 Y268A 268 Y A 0.064 Neutral PMS2 P54278 Y268C 268 Y C 0.052 Neutral PMS2 P54278 Y268D 268 Y D 0.032 Neutral PMS2 P54278 Y268E 268 Y E 0.032 Neutral PMS2 P54278 Y268F 268 Y F 0.016 Neutral PMS2 P54278 Y268G 268 Y G 0.164 Neutral PMS2 P54278 Y268H 268 Y H 0.002 Neutral PMS2 P54278 Y268I 268 Y I 0.016 Neutral PMS2 P54278 Y268K 268 Y K 0.022 Neutral PMS2 P54278 Y268L 268 Y L 0.012 Neutral PMS2 P54278 Y268M 268 Y M 0.074 Neutral PMS2 P54278 Y268N 268 Y N 0.072 Neutral PMS2 P54278 Y268P 268 Y P 0.05 Neutral PMS2 P54278 Y268Q 268 Y Q 0.064 Neutral PMS2 P54278 Y268R 268 Y R 0.032 Neutral PMS2 P54278 Y268S 268 Y S 0.096 Neutral PMS2 P54278 Y268T 268 Y T 0.052 Neutral PMS2 P54278 Y268V 268 Y V 0.03 Neutral PMS2 P54278 Y268W 268 Y W 0.048 Neutral PMS2 P54278 I269A 269 I A 0.134 Neutral PMS2 P54278 I269C 269 I C 0.246 Neutral PMS2 P54278 I269D 269 I D 0.4 Neutral PMS2 P54278 I269E 269 I E 0.386 Neutral PMS2 P54278 I269F 269 I F 0.126 Neutral PMS2 P54278 I269G 269 I G 0.13 Neutral PMS2 P54278 I269H 269 I H 0.248 Neutral PMS2 P54278 I269K 269 I K 0.436 Neutral PMS2 P54278 I269L 269 I L 0.012 Neutral PMS2 P54278 I269M 269 I M 0.388 Neutral PMS2 P54278 I269N 269 I N 0.546 Pathogenic PMS2 P54278 I269P 269 I P 0.492 Neutral PMS2 P54278 I269Q 269 I Q 0.16 Neutral PMS2 P54278 I269R 269 I R 0.646 Pathogenic PMS2 P54278 I269S 269 I S 0.088 Neutral PMS2 P54278 I269T 269 I T 0.272 Neutral PMS2 P54278 I269V 269 I V 0.018 Neutral PMS2 P54278 I269W 269 I W 0.462 Neutral PMS2 P54278 I269Y 269 I Y 0.668 Pathogenic PMS2 P54278 C27A 27 C A 0.134 Neutral PMS2 P54278 C27D 27 C D 0.586 Pathogenic PMS2 P54278 C27E 27 C E 0.622 Pathogenic PMS2 P54278 C27F 27 C F 0.754 Pathogenic PMS2 P54278 C27G 27 C G 0.092 Neutral PMS2 P54278 C27H 27 C H 0.76 Pathogenic PMS2 P54278 C27I 27 C I 0.842 Pathogenic PMS2 P54278 C27K 27 C K 0.218 Neutral PMS2 P54278 C27L 27 C L 0.794 Pathogenic PMS2 P54278 C27M 27 C M 0.596 Pathogenic PMS2 P54278 C27N 27 C N 0.144 Neutral PMS2 P54278 C27P 27 C P 0.896 Pathogenic PMS2 P54278 C27Q 27 C Q 0.042 Neutral PMS2 P54278 C27R 27 C R 0.626 Pathogenic PMS2 P54278 C27S 27 C S 0.064 Neutral PMS2 P54278 C27T 27 C T 0.048 Neutral PMS2 P54278 C27V 27 C V 0.208 Neutral PMS2 P54278 C27W 27 C W 0.96 Pathogenic PMS2 P54278 C27Y 27 C Y 0.608 Pathogenic PMS2 P54278 S270A 270 S A 0.03 Neutral PMS2 P54278 S270C 270 S C 0.06 Neutral PMS2 P54278 S270D 270 S D 0.006 Neutral PMS2 P54278 S270E 270 S E 0.23 Neutral PMS2 P54278 S270F 270 S F 0.52 Pathogenic PMS2 P54278 S270G 270 S G 0.076 Neutral PMS2 P54278 S270H 270 S H 0.258 Neutral PMS2 P54278 S270I 270 S I 0.218 Neutral PMS2 P54278 S270K 270 S K 0.236 Neutral PMS2 P54278 S270L 270 S L 0.116 Neutral PMS2 P54278 S270M 270 S M 0.382 Neutral PMS2 P54278 S270N 270 S N 0.012 Neutral PMS2 P54278 S270P 270 S P 0.214 Neutral PMS2 P54278 S270Q 270 S Q 0.258 Neutral PMS2 P54278 S270R 270 S R 0.244 Neutral PMS2 P54278 S270T 270 S T 0.016 Neutral PMS2 P54278 S270V 270 S V 0.044 Neutral PMS2 P54278 S270W 270 S W 0.724 Pathogenic PMS2 P54278 S270Y 270 S Y 0.702 Pathogenic PMS2 P54278 G271A 271 G A 0.46 Neutral PMS2 P54278 G271C 271 G C 0.542 Pathogenic PMS2 P54278 G271D 271 G D 0.846 Pathogenic PMS2 P54278 G271E 271 G E 0.686 Pathogenic PMS2 P54278 G271F 271 G F 0.708 Pathogenic PMS2 P54278 G271H 271 G H 0.976 Pathogenic PMS2 P54278 G271I 271 G I 0.964 Pathogenic PMS2 P54278 G271K 271 G K 0.754 Pathogenic PMS2 P54278 G271L 271 G L 0.974 Pathogenic PMS2 P54278 G271M 271 G M 0.99 Pathogenic PMS2 P54278 G271N 271 G N 0.818 Pathogenic PMS2 P54278 G271P 271 G P 0.938 Pathogenic PMS2 P54278 G271Q 271 G Q 0.872 Pathogenic PMS2 P54278 G271R 271 G R 0.744 Pathogenic PMS2 P54278 G271S 271 G S 0.088 Neutral PMS2 P54278 G271T 271 G T 0.594 Pathogenic PMS2 P54278 G271V 271 G V 0.772 Pathogenic PMS2 P54278 G271W 271 G W 0.966 Pathogenic PMS2 P54278 G271Y 271 G Y 0.958 Pathogenic PMS2 P54278 F272A 272 F A 0.304 Neutral PMS2 P54278 F272C 272 F C 0.256 Neutral PMS2 P54278 F272D 272 F D 0.516 Pathogenic PMS2 P54278 F272E 272 F E 0.124 Neutral PMS2 P54278 F272G 272 F G 0.312 Neutral PMS2 P54278 F272H 272 F H 0.032 Neutral PMS2 P54278 F272I 272 F I 0.108 Neutral PMS2 P54278 F272K 272 F K 0.544 Pathogenic PMS2 P54278 F272L 272 F L 0.05 Neutral PMS2 P54278 F272M 272 F M 0.192 Neutral PMS2 P54278 F272N 272 F N 0.538 Pathogenic PMS2 P54278 F272P 272 F P 0.612 Pathogenic PMS2 P54278 F272Q 272 F Q 0.34 Neutral PMS2 P54278 F272R 272 F R 0.554 Pathogenic PMS2 P54278 F272S 272 F S 0.078 Neutral PMS2 P54278 F272T 272 F T 0.066 Neutral PMS2 P54278 F272V 272 F V 0.046 Neutral PMS2 P54278 F272W 272 F W 0.862 Pathogenic PMS2 P54278 F272Y 272 F Y 0.066 Neutral PMS2 P54278 I273A 273 I A 0.07 Neutral PMS2 P54278 I273C 273 I C 0.428 Neutral PMS2 P54278 I273D 273 I D 0.514 Pathogenic PMS2 P54278 I273E 273 I E 0.478 Neutral PMS2 P54278 I273F 273 I F 0.308 Neutral PMS2 P54278 I273G 273 I G 0.324 Neutral PMS2 P54278 I273H 273 I H 0.058 Neutral PMS2 P54278 I273K 273 I K 0.628 Pathogenic PMS2 P54278 I273L 273 I L 0.004 Neutral PMS2 P54278 I273M 273 I M 0.04 Neutral PMS2 P54278 I273N 273 I N 0.298 Neutral PMS2 P54278 I273P 273 I P 0.766 Pathogenic PMS2 P54278 I273Q 273 I Q 0.648 Pathogenic PMS2 P54278 I273R 273 I R 0.834 Pathogenic PMS2 P54278 I273S 273 I S 0.44 Neutral PMS2 P54278 I273T 273 I T 0.362 Neutral PMS2 P54278 I273V 273 I V 0.052 Neutral PMS2 P54278 I273W 273 I W 0.886 Pathogenic PMS2 P54278 I273Y 273 I Y 0.826 Pathogenic PMS2 P54278 S274A 274 S A 0.372 Neutral PMS2 P54278 S274C 274 S C 0.176 Neutral PMS2 P54278 S274D 274 S D 0.762 Pathogenic PMS2 P54278 S274E 274 S E 0.662 Pathogenic PMS2 P54278 S274F 274 S F 0.694 Pathogenic PMS2 P54278 S274G 274 S G 0.512 Pathogenic PMS2 P54278 S274H 274 S H 0.694 Pathogenic PMS2 P54278 S274I 274 S I 0.624 Pathogenic PMS2 P54278 S274K 274 S K 0.878 Pathogenic PMS2 P54278 S274L 274 S L 0.468 Neutral PMS2 P54278 S274M 274 S M 0.99 Pathogenic PMS2 P54278 S274N 274 S N 0.722 Pathogenic PMS2 P54278 S274P 274 S P 0.312 Neutral PMS2 P54278 S274Q 274 S Q 0.582 Pathogenic PMS2 P54278 S274R 274 S R 0.918 Pathogenic PMS2 P54278 S274T 274 S T 0.338 Neutral PMS2 P54278 S274V 274 S V 0.32 Neutral PMS2 P54278 S274W 274 S W 0.94 Pathogenic PMS2 P54278 S274Y 274 S Y 0.77 Pathogenic PMS2 P54278 Q275A 275 Q A 0.218 Neutral PMS2 P54278 Q275C 275 Q C 0.396 Neutral PMS2 P54278 Q275D 275 Q D 0.284 Neutral PMS2 P54278 Q275E 275 Q E 0.508 Pathogenic PMS2 P54278 Q275F 275 Q F 0.758 Pathogenic PMS2 P54278 Q275G 275 Q G 0.354 Neutral PMS2 P54278 Q275H 275 Q H 0.052 Neutral PMS2 P54278 Q275I 275 Q I 0.852 Pathogenic PMS2 P54278 Q275K 275 Q K 0.04 Neutral PMS2 P54278 Q275L 275 Q L 0.696 Pathogenic PMS2 P54278 Q275M 275 Q M 0.664 Pathogenic PMS2 P54278 Q275N 275 Q N 0.146 Neutral PMS2 P54278 Q275P 275 Q P 0.874 Pathogenic PMS2 P54278 Q275R 275 Q R 0.094 Neutral PMS2 P54278 Q275S 275 Q S 0.076 Neutral PMS2 P54278 Q275T 275 Q T 0.022 Neutral PMS2 P54278 Q275V 275 Q V 0.202 Neutral PMS2 P54278 Q275W 275 Q W 0.886 Pathogenic PMS2 P54278 Q275Y 275 Q Y 0.9 Pathogenic PMS2 P54278 C276A 276 C A 0.014 Neutral PMS2 P54278 C276D 276 C D 0.186 Neutral PMS2 P54278 C276E 276 C E 0.312 Neutral PMS2 P54278 C276F 276 C F 0.474 Neutral PMS2 P54278 C276G 276 C G 0.014 Neutral PMS2 P54278 C276H 276 C H 0.478 Neutral PMS2 P54278 C276I 276 C I 0.634 Pathogenic PMS2 P54278 C276K 276 C K 0.402 Neutral PMS2 P54278 C276L 276 C L 0.506 Pathogenic PMS2 P54278 C276M 276 C M 0.334 Neutral PMS2 P54278 C276N 276 C N 0.114 Neutral PMS2 P54278 C276P 276 C P 0.066 Neutral PMS2 P54278 C276Q 276 C Q 0.326 Neutral PMS2 P54278 C276R 276 C R 0.472 Neutral PMS2 P54278 C276S 276 C S 0.022 Neutral PMS2 P54278 C276T 276 C T 0.366 Neutral PMS2 P54278 C276V 276 C V 0.228 Neutral PMS2 P54278 C276W 276 C W 0.824 Pathogenic PMS2 P54278 C276Y 276 C Y 0.806 Pathogenic PMS2 P54278 T277A 277 T A 0.006 Neutral PMS2 P54278 T277C 277 T C 0.096 Neutral PMS2 P54278 T277D 277 T D 0.028 Neutral PMS2 P54278 T277E 277 T E 0.03 Neutral PMS2 P54278 T277F 277 T F 0.37 Neutral PMS2 P54278 T277G 277 T G 0.004 Neutral PMS2 P54278 T277H 277 T H 0.184 Neutral PMS2 P54278 T277I 277 T I 0.142 Neutral PMS2 P54278 T277K 277 T K 0.102 Neutral PMS2 P54278 T277L 277 T L 0.018 Neutral PMS2 P54278 T277M 277 T M 0.046 Neutral PMS2 P54278 T277N 277 T N 0.004 Neutral PMS2 P54278 T277P 277 T P 0.178 Neutral PMS2 P54278 T277Q 277 T Q 0.004 Neutral PMS2 P54278 T277R 277 T R 0.226 Neutral PMS2 P54278 T277S 277 T S 0.002 Neutral PMS2 P54278 T277V 277 T V 0.02 Neutral PMS2 P54278 T277W 277 T W 0.636 Pathogenic PMS2 P54278 T277Y 277 T Y 0.596 Pathogenic PMS2 P54278 H278A 278 H A 0.064 Neutral PMS2 P54278 H278C 278 H C 0.128 Neutral PMS2 P54278 H278D 278 H D 0.122 Neutral PMS2 P54278 H278E 278 H E 0.114 Neutral PMS2 P54278 H278F 278 H F 0.052 Neutral PMS2 P54278 H278G 278 H G 0.236 Neutral PMS2 P54278 H278I 278 H I 0.57 Pathogenic PMS2 P54278 H278K 278 H K 0.408 Neutral PMS2 P54278 H278L 278 H L 0.226 Neutral PMS2 P54278 H278M 278 H M 0.392 Neutral PMS2 P54278 H278N 278 H N 0.03 Neutral PMS2 P54278 H278P 278 H P 0.06 Neutral PMS2 P54278 H278Q 278 H Q 0.008 Neutral PMS2 P54278 H278R 278 H R 0.108 Neutral PMS2 P54278 H278S 278 H S 0.022 Neutral PMS2 P54278 H278T 278 H T 0.154 Neutral PMS2 P54278 H278V 278 H V 0.036 Neutral PMS2 P54278 H278W 278 H W 0.786 Pathogenic PMS2 P54278 H278Y 278 H Y 0.044 Neutral PMS2 P54278 G279A 279 G A 0.098 Neutral PMS2 P54278 G279C 279 G C 0.81 Pathogenic PMS2 P54278 G279D 279 G D 0.678 Pathogenic PMS2 P54278 G279E 279 G E 0.836 Pathogenic PMS2 P54278 G279F 279 G F 0.98 Pathogenic PMS2 P54278 G279H 279 G H 0.976 Pathogenic PMS2 P54278 G279I 279 G I 0.964 Pathogenic PMS2 P54278 G279K 279 G K 0.982 Pathogenic PMS2 P54278 G279L 279 G L 0.974 Pathogenic PMS2 P54278 G279M 279 G M 0.99 Pathogenic PMS2 P54278 G279N 279 G N 0.572 Pathogenic PMS2 P54278 G279P 279 G P 0.928 Pathogenic PMS2 P54278 G279Q 279 G Q 0.87 Pathogenic PMS2 P54278 G279R 279 G R 0.992 Pathogenic PMS2 P54278 G279S 279 G S 0.178 Neutral PMS2 P54278 G279T 279 G T 0.626 Pathogenic PMS2 P54278 G279V 279 G V 0.77 Pathogenic PMS2 P54278 G279W 279 G W 0.966 Pathogenic PMS2 P54278 G279Y 279 G Y 0.958 Pathogenic PMS2 P54278 S28A 28 S A 0.056 Neutral PMS2 P54278 S28C 28 S C 0.54 Pathogenic PMS2 P54278 S28D 28 S D 0.58 Pathogenic PMS2 P54278 S28E 28 S E 0.606 Pathogenic PMS2 P54278 S28F 28 S F 0.778 Pathogenic PMS2 P54278 S28G 28 S G 0.394 Neutral PMS2 P54278 S28H 28 S H 0.488 Neutral PMS2 P54278 S28I 28 S I 0.648 Pathogenic PMS2 P54278 S28K 28 S K 0.466 Neutral PMS2 P54278 S28L 28 S L 0.364 Neutral PMS2 P54278 S28M 28 S M 0.952 Pathogenic PMS2 P54278 S28N 28 S N 0.52 Pathogenic PMS2 P54278 S28P 28 S P 0.692 Pathogenic PMS2 P54278 S28Q 28 S Q 0.56 Pathogenic PMS2 P54278 S28R 28 S R 0.484 Neutral PMS2 P54278 S28T 28 S T 0.086 Neutral PMS2 P54278 S28V 28 S V 0.772 Pathogenic PMS2 P54278 S28W 28 S W 0.918 Pathogenic PMS2 P54278 S28Y 28 S Y 0.884 Pathogenic PMS2 P54278 V280A 280 V A 0.002 Neutral PMS2 P54278 V280C 280 V C 0.012 Neutral PMS2 P54278 V280D 280 V D 0.034 Neutral PMS2 P54278 V280E 280 V E 0.056 Neutral PMS2 P54278 V280F 280 V F 0.266 Neutral PMS2 P54278 V280G 280 V G 0.058 Neutral PMS2 P54278 V280H 280 V H 0.11 Neutral PMS2 P54278 V280I 280 V I 0.006 Neutral PMS2 P54278 V280K 280 V K 0.24 Neutral PMS2 P54278 V280L 280 V L 0.002 Neutral PMS2 P54278 V280M 280 V M 0.094 Neutral PMS2 P54278 V280N 280 V N 0.046 Neutral PMS2 P54278 V280P 280 V P 0.268 Neutral PMS2 P54278 V280Q 280 V Q 0.066 Neutral PMS2 P54278 V280R 280 V R 0.332 Neutral PMS2 P54278 V280S 280 V S 0.012 Neutral PMS2 P54278 V280T 280 V T 0.01 Neutral PMS2 P54278 V280W 280 V W 0.492 Neutral PMS2 P54278 V280Y 280 V Y 0.312 Neutral PMS2 P54278 G281A 281 G A 0.658 Pathogenic PMS2 P54278 G281C 281 G C 0.8 Pathogenic PMS2 P54278 G281D 281 G D 0.846 Pathogenic PMS2 P54278 G281E 281 G E 0.8 Pathogenic PMS2 P54278 G281F 281 G F 0.952 Pathogenic PMS2 P54278 G281H 281 G H 0.942 Pathogenic PMS2 P54278 G281I 281 G I 0.934 Pathogenic PMS2 P54278 G281K 281 G K 0.946 Pathogenic PMS2 P54278 G281L 281 G L 0.944 Pathogenic PMS2 P54278 G281M 281 G M 0.958 Pathogenic PMS2 P54278 G281N 281 G N 0.818 Pathogenic PMS2 P54278 G281P 281 G P 0.894 Pathogenic PMS2 P54278 G281Q 281 G Q 0.86 Pathogenic PMS2 P54278 G281R 281 G R 0.966 Pathogenic PMS2 P54278 G281S 281 G S 0.296 Neutral PMS2 P54278 G281T 281 G T 0.808 Pathogenic PMS2 P54278 G281V 281 G V 0.944 Pathogenic PMS2 P54278 G281W 281 G W 0.938 Pathogenic PMS2 P54278 G281Y 281 G Y 0.922 Pathogenic PMS2 P54278 R282A 282 R A 0.438 Neutral PMS2 P54278 R282C 282 R C 0.656 Pathogenic PMS2 P54278 R282D 282 R D 0.618 Pathogenic PMS2 P54278 R282E 282 R E 0.418 Neutral PMS2 P54278 R282F 282 R F 0.936 Pathogenic PMS2 P54278 R282G 282 R G 0.21 Neutral PMS2 P54278 R282H 282 R H 0.472 Neutral PMS2 P54278 R282I 282 R I 0.902 Pathogenic PMS2 P54278 R282K 282 R K 0.118 Neutral PMS2 P54278 R282L 282 R L 0.704 Pathogenic PMS2 P54278 R282M 282 R M 0.668 Pathogenic PMS2 P54278 R282N 282 R N 0.488 Neutral PMS2 P54278 R282P 282 R P 0.846 Pathogenic PMS2 P54278 R282Q 282 R Q 0.174 Neutral PMS2 P54278 R282S 282 R S 0.446 Neutral PMS2 P54278 R282T 282 R T 0.536 Pathogenic PMS2 P54278 R282V 282 R V 0.362 Neutral PMS2 P54278 R282W 282 R W 0.914 Pathogenic PMS2 P54278 R282Y 282 R Y 0.892 Pathogenic PMS2 P54278 S283A 283 S A 0.04 Neutral PMS2 P54278 S283C 283 S C 0.36 Neutral PMS2 P54278 S283D 283 S D 0.382 Neutral PMS2 P54278 S283E 283 S E 0.616 Pathogenic PMS2 P54278 S283F 283 S F 0.776 Pathogenic PMS2 P54278 S283G 283 S G 0.036 Neutral PMS2 P54278 S283H 283 S H 0.7 Pathogenic PMS2 P54278 S283I 283 S I 0.48 Neutral PMS2 P54278 S283K 283 S K 0.632 Pathogenic PMS2 P54278 S283L 283 S L 0.178 Neutral PMS2 P54278 S283M 283 S M 0.916 Pathogenic PMS2 P54278 S283N 283 S N 0.024 Neutral PMS2 P54278 S283P 283 S P 0.494 Neutral PMS2 P54278 S283Q 283 S Q 0.406 Neutral PMS2 P54278 S283R 283 S R 0.626 Pathogenic PMS2 P54278 S283T 283 S T 0.042 Neutral PMS2 P54278 S283V 283 S V 0.78 Pathogenic PMS2 P54278 S283W 283 S W 0.918 Pathogenic PMS2 P54278 S283Y 283 S Y 0.892 Pathogenic PMS2 P54278 S284A 284 S A 0.012 Neutral PMS2 P54278 S284C 284 S C 0.09 Neutral PMS2 P54278 S284D 284 S D 0.132 Neutral PMS2 P54278 S284E 284 S E 0.404 Neutral PMS2 P54278 S284F 284 S F 0.606 Pathogenic PMS2 P54278 S284G 284 S G 0.01 Neutral PMS2 P54278 S284H 284 S H 0.516 Pathogenic PMS2 P54278 S284I 284 S I 0.256 Neutral PMS2 P54278 S284K 284 S K 0.44 Neutral PMS2 P54278 S284L 284 S L 0.048 Neutral PMS2 P54278 S284M 284 S M 0.464 Neutral PMS2 P54278 S284N 284 S N 0.12 Neutral PMS2 P54278 S284P 284 S P 0.254 Neutral PMS2 P54278 S284Q 284 S Q 0.328 Neutral PMS2 P54278 S284R 284 S R 0.318 Neutral PMS2 P54278 S284T 284 S T 0.02 Neutral PMS2 P54278 S284V 284 S V 0.538 Pathogenic PMS2 P54278 S284W 284 S W 0.816 Pathogenic PMS2 P54278 S284Y 284 S Y 0.78 Pathogenic PMS2 P54278 T285A 285 T A 0.036 Neutral PMS2 P54278 T285C 285 T C 0.122 Neutral PMS2 P54278 T285D 285 T D 0.58 Pathogenic PMS2 P54278 T285E 285 T E 0.504 Pathogenic PMS2 P54278 T285F 285 T F 0.776 Pathogenic PMS2 P54278 T285G 285 T G 0.026 Neutral PMS2 P54278 T285H 285 T H 0.624 Pathogenic PMS2 P54278 T285I 285 T I 0.458 Neutral PMS2 P54278 T285K 285 T K 0.112 Neutral PMS2 P54278 T285L 285 T L 0.156 Neutral PMS2 P54278 T285M 285 T M 0.728 Pathogenic PMS2 P54278 T285N 285 T N 0.02 Neutral PMS2 P54278 T285P 285 T P 0.11 Neutral PMS2 P54278 T285Q 285 T Q 0.414 Neutral PMS2 P54278 T285R 285 T R 0.488 Neutral PMS2 P54278 T285S 285 T S 0.012 Neutral PMS2 P54278 T285V 285 T V 0.758 Pathogenic PMS2 P54278 T285W 285 T W 0.954 Pathogenic PMS2 P54278 T285Y 285 T Y 0.95 Pathogenic PMS2 P54278 D286A 286 D A 0.668 Pathogenic PMS2 P54278 D286C 286 D C 0.894 Pathogenic PMS2 P54278 D286E 286 D E 0.234 Neutral PMS2 P54278 D286F 286 D F 0.982 Pathogenic PMS2 P54278 D286G 286 D G 0.22 Neutral PMS2 P54278 D286H 286 D H 0.586 Pathogenic PMS2 P54278 D286I 286 D I 0.972 Pathogenic PMS2 P54278 D286K 286 D K 0.804 Pathogenic PMS2 P54278 D286L 286 D L 0.976 Pathogenic PMS2 P54278 D286M 286 D M 0.93 Pathogenic PMS2 P54278 D286N 286 D N 0.222 Neutral PMS2 P54278 D286P 286 D P 0.334 Neutral PMS2 P54278 D286Q 286 D Q 0.768 Pathogenic PMS2 P54278 D286R 286 D R 0.888 Pathogenic PMS2 P54278 D286S 286 D S 0.198 Neutral PMS2 P54278 D286T 286 D T 0.164 Neutral PMS2 P54278 D286V 286 D V 0.756 Pathogenic PMS2 P54278 D286W 286 D W 0.986 Pathogenic PMS2 P54278 D286Y 286 D Y 0.98 Pathogenic PMS2 P54278 R287A 287 R A 0.294 Neutral PMS2 P54278 R287C 287 R C 0.394 Neutral PMS2 P54278 R287D 287 R D 0.244 Neutral PMS2 P54278 R287E 287 R E 0.78 Pathogenic PMS2 P54278 R287F 287 R F 0.738 Pathogenic PMS2 P54278 R287G 287 R G 0.43 Neutral PMS2 P54278 R287H 287 R H 0.182 Neutral PMS2 P54278 R287I 287 R I 0.974 Pathogenic PMS2 P54278 R287K 287 R K 0.288 Neutral PMS2 P54278 R287L 287 R L 0.984 Pathogenic PMS2 P54278 R287M 287 R M 0.762 Pathogenic PMS2 P54278 R287N 287 R N 0.654 Pathogenic PMS2 P54278 R287P 287 R P 0.984 Pathogenic PMS2 P54278 R287Q 287 R Q 0.504 Pathogenic PMS2 P54278 R287S 287 R S 0.216 Neutral PMS2 P54278 R287T 287 R T 0.344 Neutral PMS2 P54278 R287V 287 R V 0.976 Pathogenic PMS2 P54278 R287W 287 R W 0.948 Pathogenic PMS2 P54278 R287Y 287 R Y 0.952 Pathogenic PMS2 P54278 Q288A 288 Q A 0.68 Pathogenic PMS2 P54278 Q288C 288 Q C 0.66 Pathogenic PMS2 P54278 Q288D 288 Q D 0.742 Pathogenic PMS2 P54278 Q288E 288 Q E 0.844 Pathogenic PMS2 P54278 Q288F 288 Q F 0.924 Pathogenic PMS2 P54278 Q288G 288 Q G 0.572 Pathogenic PMS2 P54278 Q288H 288 Q H 0.836 Pathogenic PMS2 P54278 Q288I 288 Q I 0.536 Pathogenic PMS2 P54278 Q288K 288 Q K 0.968 Pathogenic PMS2 P54278 Q288L 288 Q L 0.45 Neutral PMS2 P54278 Q288M 288 Q M 0.734 Pathogenic PMS2 P54278 Q288N 288 Q N 0.366 Neutral PMS2 P54278 Q288P 288 Q P 0.918 Pathogenic PMS2 P54278 Q288R 288 Q R 0.83 Pathogenic PMS2 P54278 Q288S 288 Q S 0.268 Neutral PMS2 P54278 Q288T 288 Q T 0.278 Neutral PMS2 P54278 Q288V 288 Q V 0.494 Neutral PMS2 P54278 Q288W 288 Q W 0.96 Pathogenic PMS2 P54278 Q288Y 288 Q Y 0.95 Pathogenic PMS2 P54278 F289A 289 F A 0.198 Neutral PMS2 P54278 F289C 289 F C 0.16 Neutral PMS2 P54278 F289D 289 F D 0.608 Pathogenic PMS2 P54278 F289E 289 F E 0.712 Pathogenic PMS2 P54278 F289G 289 F G 0.308 Neutral PMS2 P54278 F289H 289 F H 0.196 Neutral PMS2 P54278 F289I 289 F I 0.454 Neutral PMS2 P54278 F289K 289 F K 0.128 Neutral PMS2 P54278 F289L 289 F L 0.138 Neutral PMS2 P54278 F289M 289 F M 0.058 Neutral PMS2 P54278 F289N 289 F N 0.454 Neutral PMS2 P54278 F289P 289 F P 0.732 Pathogenic PMS2 P54278 F289Q 289 F Q 0.252 Neutral PMS2 P54278 F289R 289 F R 0.188 Neutral PMS2 P54278 F289S 289 F S 0.124 Neutral PMS2 P54278 F289T 289 F T 0.362 Neutral PMS2 P54278 F289V 289 F V 0.486 Neutral PMS2 P54278 F289W 289 F W 0.812 Pathogenic PMS2 P54278 F289Y 289 F Y 0.094 Neutral PMS2 P54278 G29A 29 G A 0.288 Neutral PMS2 P54278 G29C 29 G C 0.75 Pathogenic PMS2 P54278 G29D 29 G D 0.704 Pathogenic PMS2 P54278 G29E 29 G E 0.978 Pathogenic PMS2 P54278 G29F 29 G F 0.982 Pathogenic PMS2 P54278 G29H 29 G H 0.98 Pathogenic PMS2 P54278 G29I 29 G I 0.972 Pathogenic PMS2 P54278 G29K 29 G K 0.982 Pathogenic PMS2 P54278 G29L 29 G L 0.982 Pathogenic PMS2 P54278 G29M 29 G M 0.988 Pathogenic PMS2 P54278 G29N 29 G N 0.916 Pathogenic PMS2 P54278 G29P 29 G P 0.968 Pathogenic PMS2 P54278 G29Q 29 G Q 0.96 Pathogenic PMS2 P54278 G29R 29 G R 0.996 Pathogenic PMS2 P54278 G29S 29 G S 0.306 Neutral PMS2 P54278 G29T 29 G T 0.642 Pathogenic PMS2 P54278 G29V 29 G V 0.982 Pathogenic PMS2 P54278 G29W 29 G W 0.972 Pathogenic PMS2 P54278 G29Y 29 G Y 0.972 Pathogenic PMS2 P54278 F290A 290 F A 0.116 Neutral PMS2 P54278 F290C 290 F C 0.292 Neutral PMS2 P54278 F290D 290 F D 0.57 Pathogenic PMS2 P54278 F290E 290 F E 0.278 Neutral PMS2 P54278 F290G 290 F G 0.34 Neutral PMS2 P54278 F290H 290 F H 0.334 Neutral PMS2 P54278 F290I 290 F I 0.05 Neutral PMS2 P54278 F290K 290 F K 0.078 Neutral PMS2 P54278 F290L 290 F L 0.204 Neutral PMS2 P54278 F290M 290 F M 0.128 Neutral PMS2 P54278 F290N 290 F N 0.272 Neutral PMS2 P54278 F290P 290 F P 0.76 Pathogenic PMS2 P54278 F290Q 290 F Q 0.088 Neutral PMS2 P54278 F290R 290 F R 0.102 Neutral PMS2 P54278 F290S 290 F S 0.07 Neutral PMS2 P54278 F290T 290 F T 0.056 Neutral PMS2 P54278 F290V 290 F V 0.19 Neutral PMS2 P54278 F290W 290 F W 0.866 Pathogenic PMS2 P54278 F290Y 290 F Y 0.04 Neutral PMS2 P54278 F291A 291 F A 0.212 Neutral PMS2 P54278 F291C 291 F C 0.212 Neutral PMS2 P54278 F291D 291 F D 0.808 Pathogenic PMS2 P54278 F291E 291 F E 0.518 Pathogenic PMS2 P54278 F291G 291 F G 0.488 Neutral PMS2 P54278 F291H 291 F H 0.626 Pathogenic PMS2 P54278 F291I 291 F I 0.206 Neutral PMS2 P54278 F291K 291 F K 0.86 Pathogenic PMS2 P54278 F291L 291 F L 0.08 Neutral PMS2 P54278 F291M 291 F M 0.118 Neutral PMS2 P54278 F291N 291 F N 0.732 Pathogenic PMS2 P54278 F291P 291 F P 0.884 Pathogenic PMS2 P54278 F291Q 291 F Q 0.77 Pathogenic PMS2 P54278 F291R 291 F R 0.926 Pathogenic PMS2 P54278 F291S 291 F S 0.222 Neutral PMS2 P54278 F291T 291 F T 0.356 Neutral PMS2 P54278 F291V 291 F V 0.394 Neutral PMS2 P54278 F291W 291 F W 0.852 Pathogenic PMS2 P54278 F291Y 291 F Y 0.216 Neutral PMS2 P54278 I292A 292 I A 0.158 Neutral PMS2 P54278 I292C 292 I C 0.432 Neutral PMS2 P54278 I292D 292 I D 0.624 Pathogenic PMS2 P54278 I292E 292 I E 0.608 Pathogenic PMS2 P54278 I292F 292 I F 0.148 Neutral PMS2 P54278 I292G 292 I G 0.596 Pathogenic PMS2 P54278 I292H 292 I H 0.508 Pathogenic PMS2 P54278 I292K 292 I K 0.616 Pathogenic PMS2 P54278 I292L 292 I L 0.012 Neutral PMS2 P54278 I292M 292 I M 0.384 Neutral PMS2 P54278 I292N 292 I N 0.666 Pathogenic PMS2 P54278 I292P 292 I P 0.75 Pathogenic PMS2 P54278 I292Q 292 I Q 0.642 Pathogenic PMS2 P54278 I292R 292 I R 0.822 Pathogenic PMS2 P54278 I292S 292 I S 0.21 Neutral PMS2 P54278 I292T 292 I T 0.306 Neutral PMS2 P54278 I292V 292 I V 0.054 Neutral PMS2 P54278 I292W 292 I W 0.87 Pathogenic PMS2 P54278 I292Y 292 I Y 0.7 Pathogenic PMS2 P54278 N293A 293 N A 0.312 Neutral PMS2 P54278 N293C 293 N C 0.802 Pathogenic PMS2 P54278 N293D 293 N D 0.854 Pathogenic PMS2 P54278 N293E 293 N E 0.74 Pathogenic PMS2 P54278 N293F 293 N F 0.966 Pathogenic PMS2 P54278 N293G 293 N G 0.402 Neutral PMS2 P54278 N293H 293 N H 0.844 Pathogenic PMS2 P54278 N293I 293 N I 0.618 Pathogenic PMS2 P54278 N293K 293 N K 0.986 Pathogenic PMS2 P54278 N293L 293 N L 0.966 Pathogenic PMS2 P54278 N293M 293 N M 0.972 Pathogenic PMS2 P54278 N293P 293 N P 0.896 Pathogenic PMS2 P54278 N293Q 293 N Q 0.966 Pathogenic PMS2 P54278 N293R 293 N R 0.924 Pathogenic PMS2 P54278 N293S 293 N S 0.942 Pathogenic PMS2 P54278 N293T 293 N T 0.686 Pathogenic PMS2 P54278 N293V 293 N V 0.99 Pathogenic PMS2 P54278 N293W 293 N W 0.978 Pathogenic PMS2 P54278 N293Y 293 N Y 0.974 Pathogenic PMS2 P54278 R294A 294 R A 0.134 Neutral PMS2 P54278 R294C 294 R C 0.648 Pathogenic PMS2 P54278 R294D 294 R D 0.54 Pathogenic PMS2 P54278 R294E 294 R E 0.538 Pathogenic PMS2 P54278 R294F 294 R F 0.906 Pathogenic PMS2 P54278 R294G 294 R G 0.026 Neutral PMS2 P54278 R294H 294 R H 0.49 Neutral PMS2 P54278 R294I 294 R I 0.886 Pathogenic PMS2 P54278 R294K 294 R K 0.048 Neutral PMS2 P54278 R294L 294 R L 0.732 Pathogenic PMS2 P54278 R294M 294 R M 0.052 Neutral PMS2 P54278 R294N 294 R N 0.026 Neutral PMS2 P54278 R294P 294 R P 0.82 Pathogenic PMS2 P54278 R294Q 294 R Q 0.02 Neutral PMS2 P54278 R294S 294 R S 0.212 Neutral PMS2 P54278 R294T 294 R T 0.218 Neutral PMS2 P54278 R294V 294 R V 0.656 Pathogenic PMS2 P54278 R294W 294 R W 0.882 Pathogenic PMS2 P54278 R294Y 294 R Y 0.864 Pathogenic PMS2 P54278 R295A 295 R A 0.566 Pathogenic PMS2 P54278 R295C 295 R C 0.424 Neutral PMS2 P54278 R295D 295 R D 0.676 Pathogenic PMS2 P54278 R295E 295 R E 0.776 Pathogenic PMS2 P54278 R295F 295 R F 0.966 Pathogenic PMS2 P54278 R295G 295 R G 0.14 Neutral PMS2 P54278 R295H 295 R H 0.354 Neutral PMS2 P54278 R295I 295 R I 0.974 Pathogenic PMS2 P54278 R295K 295 R K 0.334 Neutral PMS2 P54278 R295L 295 R L 0.988 Pathogenic PMS2 P54278 R295M 295 R M 0.77 Pathogenic PMS2 P54278 R295N 295 R N 0.634 Pathogenic PMS2 P54278 R295P 295 R P 0.986 Pathogenic PMS2 P54278 R295Q 295 R Q 0.486 Neutral PMS2 P54278 R295S 295 R S 0.384 Neutral PMS2 P54278 R295T 295 R T 0.374 Neutral PMS2 P54278 R295V 295 R V 0.974 Pathogenic PMS2 P54278 R295W 295 R W 0.95 Pathogenic PMS2 P54278 R295Y 295 R Y 0.954 Pathogenic PMS2 P54278 P296A 296 P A 0.244 Neutral PMS2 P54278 P296C 296 P C 0.9 Pathogenic PMS2 P54278 P296D 296 P D 0.456 Neutral PMS2 P54278 P296E 296 P E 0.956 Pathogenic PMS2 P54278 P296F 296 P F 0.996 Pathogenic PMS2 P54278 P296G 296 P G 0.586 Pathogenic PMS2 P54278 P296H 296 P H 0.978 Pathogenic PMS2 P54278 P296I 296 P I 0.932 Pathogenic PMS2 P54278 P296K 296 P K 0.952 Pathogenic PMS2 P54278 P296L 296 P L 0.702 Pathogenic PMS2 P54278 P296M 296 P M 0.954 Pathogenic PMS2 P54278 P296N 296 P N 0.708 Pathogenic PMS2 P54278 P296Q 296 P Q 0.842 Pathogenic PMS2 P54278 P296R 296 P R 0.98 Pathogenic PMS2 P54278 P296S 296 P S 0.114 Neutral PMS2 P54278 P296T 296 P T 0.706 Pathogenic PMS2 P54278 P296V 296 P V 0.838 Pathogenic PMS2 P54278 P296W 296 P W 0.94 Pathogenic PMS2 P54278 P296Y 296 P Y 0.94 Pathogenic PMS2 P54278 C297A 297 C A 0.72 Pathogenic PMS2 P54278 C297D 297 C D 0.95 Pathogenic PMS2 P54278 C297E 297 C E 0.528 Pathogenic PMS2 P54278 C297F 297 C F 0.716 Pathogenic PMS2 P54278 C297G 297 C G 0.932 Pathogenic PMS2 P54278 C297H 297 C H 0.862 Pathogenic PMS2 P54278 C297I 297 C I 0.394 Neutral PMS2 P54278 C297K 297 C K 0.892 Pathogenic PMS2 P54278 C297L 297 C L 0.986 Pathogenic PMS2 P54278 C297M 297 C M 0.6 Pathogenic PMS2 P54278 C297N 297 C N 0.812 Pathogenic PMS2 P54278 C297P 297 C P 0.974 Pathogenic PMS2 P54278 C297Q 297 C Q 0.678 Pathogenic PMS2 P54278 C297R 297 C R 0.998 Pathogenic PMS2 P54278 C297S 297 C S 0.572 Pathogenic PMS2 P54278 C297T 297 C T 0.748 Pathogenic PMS2 P54278 C297V 297 C V 0.266 Neutral PMS2 P54278 C297W 297 C W 0.802 Pathogenic PMS2 P54278 C297Y 297 C Y 0.984 Pathogenic PMS2 P54278 D298A 298 D A 0.32 Neutral PMS2 P54278 D298C 298 D C 0.668 Pathogenic PMS2 P54278 D298E 298 D E 0.05 Neutral PMS2 P54278 D298F 298 D F 0.576 Pathogenic PMS2 P54278 D298G 298 D G 0.066 Neutral PMS2 P54278 D298H 298 D H 0.154 Neutral PMS2 P54278 D298I 298 D I 0.862 Pathogenic PMS2 P54278 D298K 298 D K 0.698 Pathogenic PMS2 P54278 D298L 298 D L 0.726 Pathogenic PMS2 P54278 D298M 298 D M 0.37 Neutral PMS2 P54278 D298N 298 D N 0.018 Neutral PMS2 P54278 D298P 298 D P 0.75 Pathogenic PMS2 P54278 D298Q 298 D Q 0.372 Neutral PMS2 P54278 D298R 298 D R 0.504 Pathogenic PMS2 P54278 D298S 298 D S 0.33 Neutral PMS2 P54278 D298T 298 D T 0.07 Neutral PMS2 P54278 D298V 298 D V 0.754 Pathogenic PMS2 P54278 D298W 298 D W 0.936 Pathogenic PMS2 P54278 D298Y 298 D Y 0.924 Pathogenic PMS2 P54278 P299A 299 P A 0.516 Pathogenic PMS2 P54278 P299C 299 P C 0.584 Pathogenic PMS2 P54278 P299D 299 P D 0.41 Neutral PMS2 P54278 P299E 299 P E 0.708 Pathogenic PMS2 P54278 P299F 299 P F 0.668 Pathogenic PMS2 P54278 P299G 299 P G 0.212 Neutral PMS2 P54278 P299H 299 P H 0.556 Pathogenic PMS2 P54278 P299I 299 P I 0.418 Neutral PMS2 P54278 P299K 299 P K 0.142 Neutral PMS2 P54278 P299L 299 P L 0.122 Neutral PMS2 P54278 P299M 299 P M 0.222 Neutral PMS2 P54278 P299N 299 P N 0.316 Neutral PMS2 P54278 P299Q 299 P Q 0.144 Neutral PMS2 P54278 P299R 299 P R 0.764 Pathogenic PMS2 P54278 P299S 299 P S 0.032 Neutral PMS2 P54278 P299T 299 P T 0.454 Neutral PMS2 P54278 P299V 299 P V 0.572 Pathogenic PMS2 P54278 P299W 299 P W 0.924 Pathogenic PMS2 P54278 P299Y 299 P Y 0.6 Pathogenic PMS2 P54278 R3A 3 R A 0.036 Neutral PMS2 P54278 R3C 3 R C 0.148 Neutral PMS2 P54278 R3D 3 R D 0.02 Neutral PMS2 P54278 R3E 3 R E 0.086 Neutral PMS2 P54278 R3F 3 R F 0.28 Neutral PMS2 P54278 R3G 3 R G 0.006 Neutral PMS2 P54278 R3H 3 R H 0.12 Neutral PMS2 P54278 R3I 3 R I 0.194 Neutral PMS2 P54278 R3K 3 R K 0.022 Neutral PMS2 P54278 R3L 3 R L 0.012 Neutral PMS2 P54278 R3M 3 R M 0.002 Neutral PMS2 P54278 R3N 3 R N 0.016 Neutral PMS2 P54278 R3P 3 R P 0.028 Neutral PMS2 P54278 R3Q 3 R Q 0.01 Neutral PMS2 P54278 R3S 3 R S 0.062 Neutral PMS2 P54278 R3T 3 R T 0.016 Neutral PMS2 P54278 R3V 3 R V 0.178 Neutral PMS2 P54278 R3W 3 R W 0.384 Neutral PMS2 P54278 R3Y 3 R Y 0.342 Neutral PMS2 P54278 Q30A 30 Q A 0.358 Neutral PMS2 P54278 Q30C 30 Q C 0.482 Neutral PMS2 P54278 Q30D 30 Q D 0.31 Neutral PMS2 P54278 Q30E 30 Q E 0.062 Neutral PMS2 P54278 Q30F 30 Q F 0.782 Pathogenic PMS2 P54278 Q30G 30 Q G 0.402 Neutral PMS2 P54278 Q30H 30 Q H 0.746 Pathogenic PMS2 P54278 Q30I 30 Q I 0.834 Pathogenic PMS2 P54278 Q30K 30 Q K 0.098 Neutral PMS2 P54278 Q30L 30 Q L 0.244 Neutral PMS2 P54278 Q30M 30 Q M 0.672 Pathogenic PMS2 P54278 Q30N 30 Q N 0.34 Neutral PMS2 P54278 Q30P 30 Q P 0.36 Neutral PMS2 P54278 Q30R 30 Q R 0.122 Neutral PMS2 P54278 Q30S 30 Q S 0.576 Pathogenic PMS2 P54278 Q30T 30 Q T 0.06 Neutral PMS2 P54278 Q30V 30 Q V 0.65 Pathogenic PMS2 P54278 Q30W 30 Q W 0.888 Pathogenic PMS2 P54278 Q30Y 30 Q Y 0.848 Pathogenic PMS2 P54278 A300C 300 A C 0.744 Pathogenic PMS2 P54278 A300D 300 A D 0.862 Pathogenic PMS2 P54278 A300E 300 A E 0.836 Pathogenic PMS2 P54278 A300F 300 A F 0.97 Pathogenic PMS2 P54278 A300G 300 A G 0.076 Neutral PMS2 P54278 A300H 300 A H 0.872 Pathogenic PMS2 P54278 A300I 300 A I 0.624 Pathogenic PMS2 P54278 A300K 300 A K 0.548 Pathogenic PMS2 P54278 A300L 300 A L 0.646 Pathogenic PMS2 P54278 A300M 300 A M 0.692 Pathogenic PMS2 P54278 A300N 300 A N 0.762 Pathogenic PMS2 P54278 A300P 300 A P 0.154 Neutral PMS2 P54278 A300Q 300 A Q 0.54 Pathogenic PMS2 P54278 A300R 300 A R 0.772 Pathogenic PMS2 P54278 A300S 300 A S 0.14 Neutral PMS2 P54278 A300T 300 A T 0.048 Neutral PMS2 P54278 A300V 300 A V 0.138 Neutral PMS2 P54278 A300W 300 A W 0.958 Pathogenic PMS2 P54278 A300Y 300 A Y 0.944 Pathogenic PMS2 P54278 K301A 301 K A 0.108 Neutral PMS2 P54278 K301C 301 K C 0.218 Neutral PMS2 P54278 K301D 301 K D 0.342 Neutral PMS2 P54278 K301E 301 K E 0.398 Neutral PMS2 P54278 K301F 301 K F 0.856 Pathogenic PMS2 P54278 K301G 301 K G 0.368 Neutral PMS2 P54278 K301H 301 K H 0.424 Neutral PMS2 P54278 K301I 301 K I 0.108 Neutral PMS2 P54278 K301L 301 K L 0.864 Pathogenic PMS2 P54278 K301M 301 K M 0.532 Pathogenic PMS2 P54278 K301N 301 K N 0.026 Neutral PMS2 P54278 K301P 301 K P 0.828 Pathogenic PMS2 P54278 K301Q 301 K Q 0.028 Neutral PMS2 P54278 K301R 301 K R 0.034 Neutral PMS2 P54278 K301S 301 K S 0.148 Neutral PMS2 P54278 K301T 301 K T 0.044 Neutral PMS2 P54278 K301V 301 K V 0.106 Neutral PMS2 P54278 K301W 301 K W 0.97 Pathogenic PMS2 P54278 K301Y 301 K Y 0.93 Pathogenic PMS2 P54278 V302A 302 V A 0.076 Neutral PMS2 P54278 V302C 302 V C 0.412 Neutral PMS2 P54278 V302D 302 V D 0.6 Pathogenic PMS2 P54278 V302E 302 V E 0.702 Pathogenic PMS2 P54278 V302F 302 V F 0.484 Neutral PMS2 P54278 V302G 302 V G 0.614 Pathogenic PMS2 P54278 V302H 302 V H 0.56 Pathogenic PMS2 P54278 V302I 302 V I 0.078 Neutral PMS2 P54278 V302K 302 V K 0.326 Neutral PMS2 P54278 V302L 302 V L 0.07 Neutral PMS2 P54278 V302M 302 V M 0.122 Neutral PMS2 P54278 V302N 302 V N 0.644 Pathogenic PMS2 P54278 V302P 302 V P 0.822 Pathogenic PMS2 P54278 V302Q 302 V Q 0.722 Pathogenic PMS2 P54278 V302R 302 V R 0.716 Pathogenic PMS2 P54278 V302S 302 V S 0.082 Neutral PMS2 P54278 V302T 302 V T 0.084 Neutral PMS2 P54278 V302W 302 V W 0.84 Pathogenic PMS2 P54278 V302Y 302 V Y 0.832 Pathogenic PMS2 P54278 C303A 303 C A 0.044 Neutral PMS2 P54278 C303D 303 C D 0.524 Pathogenic PMS2 P54278 C303E 303 C E 0.592 Pathogenic PMS2 P54278 C303F 303 C F 0.93 Pathogenic PMS2 P54278 C303G 303 C G 0.042 Neutral PMS2 P54278 C303H 303 C H 0.754 Pathogenic PMS2 P54278 C303I 303 C I 0.246 Neutral PMS2 P54278 C303K 303 C K 0.674 Pathogenic PMS2 P54278 C303L 303 C L 0.134 Neutral PMS2 P54278 C303M 303 C M 0.358 Neutral PMS2 P54278 C303N 303 C N 0.06 Neutral PMS2 P54278 C303P 303 C P 0.866 Pathogenic PMS2 P54278 C303Q 303 C Q 0.03 Neutral PMS2 P54278 C303R 303 C R 0.908 Pathogenic PMS2 P54278 C303S 303 C S 0.176 Neutral PMS2 P54278 C303T 303 C T 0.01 Neutral PMS2 P54278 C303V 303 C V 0.056 Neutral PMS2 P54278 C303W 303 C W 0.952 Pathogenic PMS2 P54278 C303Y 303 C Y 0.922 Pathogenic PMS2 P54278 R304A 304 R A 0.492 Neutral PMS2 P54278 R304C 304 R C 0.806 Pathogenic PMS2 P54278 R304D 304 R D 0.738 Pathogenic PMS2 P54278 R304E 304 R E 0.676 Pathogenic PMS2 P54278 R304F 304 R F 0.936 Pathogenic PMS2 P54278 R304G 304 R G 0.262 Neutral PMS2 P54278 R304H 304 R H 0.462 Neutral PMS2 P54278 R304I 304 R I 0.938 Pathogenic PMS2 P54278 R304K 304 R K 0.602 Pathogenic PMS2 P54278 R304L 304 R L 0.656 Pathogenic PMS2 P54278 R304M 304 R M 0.71 Pathogenic PMS2 P54278 R304N 304 R N 0.656 Pathogenic PMS2 P54278 R304P 304 R P 0.666 Pathogenic PMS2 P54278 R304Q 304 R Q 0.546 Pathogenic PMS2 P54278 R304S 304 R S 0.188 Neutral PMS2 P54278 R304T 304 R T 0.752 Pathogenic PMS2 P54278 R304V 304 R V 0.908 Pathogenic PMS2 P54278 R304W 304 R W 0.93 Pathogenic PMS2 P54278 R304Y 304 R Y 0.92 Pathogenic PMS2 P54278 L305A 305 L A 0.124 Neutral PMS2 P54278 L305C 305 L C 0.372 Neutral PMS2 P54278 L305D 305 L D 0.648 Pathogenic PMS2 P54278 L305E 305 L E 0.188 Neutral PMS2 P54278 L305F 305 L F 0.808 Pathogenic PMS2 P54278 L305G 305 L G 0.568 Pathogenic PMS2 P54278 L305H 305 L H 0.158 Neutral PMS2 P54278 L305I 305 L I 0.04 Neutral PMS2 P54278 L305K 305 L K 0.472 Neutral PMS2 P54278 L305M 305 L M 0.426 Neutral PMS2 P54278 L305N 305 L N 0.138 Neutral PMS2 P54278 L305P 305 L P 0.184 Neutral PMS2 P54278 L305Q 305 L Q 0.336 Neutral PMS2 P54278 L305R 305 L R 0.864 Pathogenic PMS2 P54278 L305S 305 L S 0.046 Neutral PMS2 P54278 L305T 305 L T 0.04 Neutral PMS2 P54278 L305V 305 L V 0.002 Neutral PMS2 P54278 L305W 305 L W 0.868 Pathogenic PMS2 P54278 L305Y 305 L Y 0.86 Pathogenic PMS2 P54278 V306A 306 V A 0.046 Neutral PMS2 P54278 V306C 306 V C 0.462 Neutral PMS2 P54278 V306D 306 V D 0.654 Pathogenic PMS2 P54278 V306E 306 V E 0.756 Pathogenic PMS2 P54278 V306F 306 V F 0.474 Neutral PMS2 P54278 V306G 306 V G 0.668 Pathogenic PMS2 P54278 V306H 306 V H 0.604 Pathogenic PMS2 P54278 V306I 306 V I 0.092 Neutral PMS2 P54278 V306K 306 V K 0.804 Pathogenic PMS2 P54278 V306L 306 V L 0.146 Neutral PMS2 P54278 V306M 306 V M 0.13 Neutral PMS2 P54278 V306N 306 V N 0.702 Pathogenic PMS2 P54278 V306P 306 V P 0.846 Pathogenic PMS2 P54278 V306Q 306 V Q 0.774 Pathogenic PMS2 P54278 V306R 306 V R 0.854 Pathogenic PMS2 P54278 V306S 306 V S 0.288 Neutral PMS2 P54278 V306T 306 V T 0.202 Neutral PMS2 P54278 V306W 306 V W 0.848 Pathogenic PMS2 P54278 V306Y 306 V Y 0.646 Pathogenic PMS2 P54278 N307A 307 N A 0.684 Pathogenic PMS2 P54278 N307C 307 N C 0.378 Neutral PMS2 P54278 N307D 307 N D 0.284 Neutral PMS2 P54278 N307E 307 N E 0.7 Pathogenic PMS2 P54278 N307F 307 N F 0.966 Pathogenic PMS2 P54278 N307G 307 N G 0.18 Neutral PMS2 P54278 N307H 307 N H 0.57 Pathogenic PMS2 P54278 N307I 307 N I 0.946 Pathogenic PMS2 P54278 N307K 307 N K 0.41 Neutral PMS2 P54278 N307L 307 N L 0.96 Pathogenic PMS2 P54278 N307M 307 N M 0.542 Pathogenic PMS2 P54278 N307P 307 N P 0.864 Pathogenic PMS2 P54278 N307Q 307 N Q 0.606 Pathogenic PMS2 P54278 N307R 307 N R 0.55 Pathogenic PMS2 P54278 N307S 307 N S 0.182 Neutral PMS2 P54278 N307T 307 N T 0.17 Neutral PMS2 P54278 N307V 307 N V 0.982 Pathogenic PMS2 P54278 N307W 307 N W 0.972 Pathogenic PMS2 P54278 N307Y 307 N Y 0.966 Pathogenic PMS2 P54278 E308A 308 E A 0.234 Neutral PMS2 P54278 E308C 308 E C 0.45 Neutral PMS2 P54278 E308D 308 E D 0.02 Neutral PMS2 P54278 E308F 308 E F 0.146 Neutral PMS2 P54278 E308G 308 E G 0.03 Neutral PMS2 P54278 E308H 308 E H 0.048 Neutral PMS2 P54278 E308I 308 E I 0.354 Neutral PMS2 P54278 E308K 308 E K 0.032 Neutral PMS2 P54278 E308L 308 E L 0.89 Pathogenic PMS2 P54278 E308M 308 E M 0.098 Neutral PMS2 P54278 E308N 308 E N 0.014 Neutral PMS2 P54278 E308P 308 E P 0.238 Neutral PMS2 P54278 E308Q 308 E Q 0.012 Neutral PMS2 P54278 E308R 308 E R 0.118 Neutral PMS2 P54278 E308S 308 E S 0.048 Neutral PMS2 P54278 E308T 308 E T 0.048 Neutral PMS2 P54278 E308V 308 E V 0.09 Neutral PMS2 P54278 E308W 308 E W 0.968 Pathogenic PMS2 P54278 E308Y 308 E Y 0.912 Pathogenic PMS2 P54278 V309A 309 V A 0.02 Neutral PMS2 P54278 V309C 309 V C 0.284 Neutral PMS2 P54278 V309D 309 V D 0.508 Pathogenic PMS2 P54278 V309E 309 V E 0.62 Pathogenic PMS2 P54278 V309F 309 V F 0.416 Neutral PMS2 P54278 V309G 309 V G 0.084 Neutral PMS2 P54278 V309H 309 V H 0.426 Neutral PMS2 P54278 V309I 309 V I 0.054 Neutral PMS2 P54278 V309K 309 V K 0.134 Neutral PMS2 P54278 V309L 309 V L 0.052 Neutral PMS2 P54278 V309M 309 V M 0.172 Neutral PMS2 P54278 V309N 309 V N 0.074 Neutral PMS2 P54278 V309P 309 V P 0.134 Neutral PMS2 P54278 V309Q 309 V Q 0.3 Neutral PMS2 P54278 V309R 309 V R 0.492 Neutral PMS2 P54278 V309S 309 V S 0.04 Neutral PMS2 P54278 V309T 309 V T 0.024 Neutral PMS2 P54278 V309W 309 V W 0.772 Pathogenic PMS2 P54278 V309Y 309 V Y 0.752 Pathogenic PMS2 P54278 V31A 31 V A 0.336 Neutral PMS2 P54278 V31C 31 V C 0.716 Pathogenic PMS2 P54278 V31D 31 V D 0.868 Pathogenic PMS2 P54278 V31E 31 V E 0.986 Pathogenic PMS2 P54278 V31F 31 V F 0.876 Pathogenic PMS2 P54278 V31G 31 V G 0.904 Pathogenic PMS2 P54278 V31H 31 V H 0.82 Pathogenic PMS2 P54278 V31I 31 V I 0.152 Neutral PMS2 P54278 V31K 31 V K 0.99 Pathogenic PMS2 P54278 V31L 31 V L 0.474 Neutral PMS2 P54278 V31M 31 V M 0.82 Pathogenic PMS2 P54278 V31N 31 V N 0.928 Pathogenic PMS2 P54278 V31P 31 V P 0.708 Pathogenic PMS2 P54278 V31Q 31 V Q 0.992 Pathogenic PMS2 P54278 V31R 31 V R 0.96 Pathogenic PMS2 P54278 V31S 31 V S 0.728 Pathogenic PMS2 P54278 V31T 31 V T 0.75 Pathogenic PMS2 P54278 V31W 31 V W 0.904 Pathogenic PMS2 P54278 V31Y 31 V Y 0.928 Pathogenic PMS2 P54278 Y310A 310 Y A 0.23 Neutral PMS2 P54278 Y310C 310 Y C 0.24 Neutral PMS2 P54278 Y310D 310 Y D 0.588 Pathogenic PMS2 P54278 Y310E 310 Y E 0.576 Pathogenic PMS2 P54278 Y310F 310 Y F 0.124 Neutral PMS2 P54278 Y310G 310 Y G 0.246 Neutral PMS2 P54278 Y310H 310 Y H 0.13 Neutral PMS2 P54278 Y310I 310 Y I 0.49 Neutral PMS2 P54278 Y310K 310 Y K 0.572 Pathogenic PMS2 P54278 Y310L 310 Y L 0.308 Neutral PMS2 P54278 Y310M 310 Y M 0.348 Neutral PMS2 P54278 Y310N 310 Y N 0.304 Neutral PMS2 P54278 Y310P 310 Y P 0.426 Neutral PMS2 P54278 Y310Q 310 Y Q 0.374 Neutral PMS2 P54278 Y310R 310 Y R 0.468 Neutral PMS2 P54278 Y310S 310 Y S 0.282 Neutral PMS2 P54278 Y310T 310 Y T 0.142 Neutral PMS2 P54278 Y310V 310 Y V 0.412 Neutral PMS2 P54278 Y310W 310 Y W 0.304 Neutral PMS2 P54278 H311A 311 H A 0.24 Neutral PMS2 P54278 H311C 311 H C 0.24 Neutral PMS2 P54278 H311D 311 H D 0.024 Neutral PMS2 P54278 H311E 311 H E 0.006 Neutral PMS2 P54278 H311F 311 H F 0.742 Pathogenic PMS2 P54278 H311G 311 H G 0.236 Neutral PMS2 P54278 H311I 311 H I 0.768 Pathogenic PMS2 P54278 H311K 311 H K 0.026 Neutral PMS2 P54278 H311L 311 H L 0.354 Neutral PMS2 P54278 H311M 311 H M 0.58 Pathogenic PMS2 P54278 H311N 311 H N 0.118 Neutral PMS2 P54278 H311P 311 H P 0.902 Pathogenic PMS2 P54278 H311Q 311 H Q 0.018 Neutral PMS2 P54278 H311R 311 H R 0.014 Neutral PMS2 P54278 H311S 311 H S 0.442 Neutral PMS2 P54278 H311T 311 H T 0.022 Neutral PMS2 P54278 H311V 311 H V 0.542 Pathogenic PMS2 P54278 H311W 311 H W 0.95 Pathogenic PMS2 P54278 H311Y 311 H Y 0.77 Pathogenic PMS2 P54278 M312A 312 M A 0.144 Neutral PMS2 P54278 M312C 312 M C 0.234 Neutral PMS2 P54278 M312D 312 M D 0.14 Neutral PMS2 P54278 M312E 312 M E 0.422 Neutral PMS2 P54278 M312F 312 M F 0.774 Pathogenic PMS2 P54278 M312G 312 M G 0.112 Neutral PMS2 P54278 M312H 312 M H 0.242 Neutral PMS2 P54278 M312I 312 M I 0.276 Neutral PMS2 P54278 M312K 312 M K 0.116 Neutral PMS2 P54278 M312L 312 M L 0.066 Neutral PMS2 P54278 M312N 312 M N 0.53 Pathogenic PMS2 P54278 M312P 312 M P 0.878 Pathogenic PMS2 P54278 M312Q 312 M Q 0.04 Neutral PMS2 P54278 M312R 312 M R 0.13 Neutral PMS2 P54278 M312S 312 M S 0.058 Neutral PMS2 P54278 M312T 312 M T 0.056 Neutral PMS2 P54278 M312V 312 M V 0.24 Neutral PMS2 P54278 M312W 312 M W 0.964 Pathogenic PMS2 P54278 M312Y 312 M Y 0.886 Pathogenic PMS2 P54278 Y313A 313 Y A 0.138 Neutral PMS2 P54278 Y313C 313 Y C 0.34 Neutral PMS2 P54278 Y313D 313 Y D 0.542 Pathogenic PMS2 P54278 Y313E 313 Y E 0.09 Neutral PMS2 P54278 Y313F 313 Y F 0.04 Neutral PMS2 P54278 Y313G 313 Y G 0.368 Neutral PMS2 P54278 Y313H 313 Y H 0.046 Neutral PMS2 P54278 Y313I 313 Y I 0.43 Neutral PMS2 P54278 Y313K 313 Y K 0.06 Neutral PMS2 P54278 Y313L 313 Y L 0.12 Neutral PMS2 P54278 Y313M 313 Y M 0.3 Neutral PMS2 P54278 Y313N 313 Y N 0.408 Neutral PMS2 P54278 Y313P 313 Y P 0.35 Neutral PMS2 P54278 Y313Q 313 Y Q 0.118 Neutral PMS2 P54278 Y313R 313 Y R 0.092 Neutral PMS2 P54278 Y313S 313 Y S 0.194 Neutral PMS2 P54278 Y313T 313 Y T 0.162 Neutral PMS2 P54278 Y313V 313 Y V 0.04 Neutral PMS2 P54278 Y313W 313 Y W 0.406 Neutral PMS2 P54278 N314A 314 N A 0.368 Neutral PMS2 P54278 N314C 314 N C 0.502 Pathogenic PMS2 P54278 N314D 314 N D 0.52 Pathogenic PMS2 P54278 N314E 314 N E 0.264 Neutral PMS2 P54278 N314F 314 N F 0.89 Pathogenic PMS2 P54278 N314G 314 N G 0.198 Neutral PMS2 P54278 N314H 314 N H 0.752 Pathogenic PMS2 P54278 N314I 314 N I 0.588 Pathogenic PMS2 P54278 N314K 314 N K 0.368 Neutral PMS2 P54278 N314L 314 N L 0.866 Pathogenic PMS2 P54278 N314M 314 N M 0.786 Pathogenic PMS2 P54278 N314P 314 N P 0.724 Pathogenic PMS2 P54278 N314Q 314 N Q 0.336 Neutral PMS2 P54278 N314R 314 N R 0.522 Pathogenic PMS2 P54278 N314S 314 N S 0.196 Neutral PMS2 P54278 N314T 314 N T 0.178 Neutral PMS2 P54278 N314V 314 N V 0.74 Pathogenic PMS2 P54278 N314W 314 N W 0.9 Pathogenic PMS2 P54278 N314Y 314 N Y 0.89 Pathogenic PMS2 P54278 R315A 315 R A 0.086 Neutral PMS2 P54278 R315C 315 R C 0.588 Pathogenic PMS2 P54278 R315D 315 R D 0.59 Pathogenic PMS2 P54278 R315E 315 R E 0.496 Neutral PMS2 P54278 R315F 315 R F 0.788 Pathogenic PMS2 P54278 R315G 315 R G 0.026 Neutral PMS2 P54278 R315H 315 R H 0.256 Neutral PMS2 P54278 R315I 315 R I 0.148 Neutral PMS2 P54278 R315K 315 R K 0.026 Neutral PMS2 P54278 R315L 315 R L 0.082 Neutral PMS2 P54278 R315M 315 R M 0.312 Neutral PMS2 P54278 R315N 315 R N 0.024 Neutral PMS2 P54278 R315P 315 R P 0.104 Neutral PMS2 P54278 R315Q 315 R Q 0.086 Neutral PMS2 P54278 R315S 315 R S 0.04 Neutral PMS2 P54278 R315T 315 R T 0.05 Neutral PMS2 P54278 R315V 315 R V 0.084 Neutral PMS2 P54278 R315W 315 R W 0.806 Pathogenic PMS2 P54278 R315Y 315 R Y 0.75 Pathogenic PMS2 P54278 H316A 316 H A 0.254 Neutral PMS2 P54278 H316C 316 H C 0.228 Neutral PMS2 P54278 H316D 316 H D 0.212 Neutral PMS2 P54278 H316E 316 H E 0.256 Neutral PMS2 P54278 H316F 316 H F 0.646 Pathogenic PMS2 P54278 H316G 316 H G 0.392 Neutral PMS2 P54278 H316I 316 H I 0.06 Neutral PMS2 P54278 H316K 316 H K 0.02 Neutral PMS2 P54278 H316L 316 H L 0.046 Neutral PMS2 P54278 H316M 316 H M 0.5 Pathogenic PMS2 P54278 H316N 316 H N 0.02 Neutral PMS2 P54278 H316P 316 H P 0.818 Pathogenic PMS2 P54278 H316Q 316 H Q 0.018 Neutral PMS2 P54278 H316R 316 H R 0.008 Neutral PMS2 P54278 H316S 316 H S 0.078 Neutral PMS2 P54278 H316T 316 H T 0.502 Pathogenic PMS2 P54278 H316V 316 H V 0.056 Neutral PMS2 P54278 H316W 316 H W 0.57 Pathogenic PMS2 P54278 H316Y 316 H Y 0.666 Pathogenic PMS2 P54278 Q317A 317 Q A 0.492 Neutral PMS2 P54278 Q317C 317 Q C 0.086 Neutral PMS2 P54278 Q317D 317 Q D 0.076 Neutral PMS2 P54278 Q317E 317 Q E 0.042 Neutral PMS2 P54278 Q317F 317 Q F 0.784 Pathogenic PMS2 P54278 Q317G 317 Q G 0.132 Neutral PMS2 P54278 Q317H 317 Q H 0.09 Neutral PMS2 P54278 Q317I 317 Q I 0.826 Pathogenic PMS2 P54278 Q317K 317 Q K 0.07 Neutral PMS2 P54278 Q317L 317 Q L 0.794 Pathogenic PMS2 P54278 Q317M 317 Q M 0.212 Neutral PMS2 P54278 Q317N 317 Q N 0.416 Neutral PMS2 P54278 Q317P 317 Q P 0.838 Pathogenic PMS2 P54278 Q317R 317 Q R 0.084 Neutral PMS2 P54278 Q317S 317 Q S 0.116 Neutral PMS2 P54278 Q317T 317 Q T 0.046 Neutral PMS2 P54278 Q317V 317 Q V 0.24 Neutral PMS2 P54278 Q317W 317 Q W 0.9 Pathogenic PMS2 P54278 Q317Y 317 Q Y 0.856 Pathogenic PMS2 P54278 Y318A 318 Y A 0.154 Neutral PMS2 P54278 Y318C 318 Y C 0.326 Neutral PMS2 P54278 Y318D 318 Y D 0.548 Pathogenic PMS2 P54278 Y318E 318 Y E 0.546 Pathogenic PMS2 P54278 Y318F 318 Y F 0.032 Neutral PMS2 P54278 Y318G 318 Y G 0.254 Neutral PMS2 P54278 Y318H 318 Y H 0.062 Neutral PMS2 P54278 Y318I 318 Y I 0.418 Neutral PMS2 P54278 Y318K 318 Y K 0.302 Neutral PMS2 P54278 Y318L 318 Y L 0.25 Neutral PMS2 P54278 Y318M 318 Y M 0.302 Neutral PMS2 P54278 Y318N 318 Y N 0.374 Neutral PMS2 P54278 Y318P 318 Y P 0.306 Neutral PMS2 P54278 Y318Q 318 Y Q 0.102 Neutral PMS2 P54278 Y318R 318 Y R 0.544 Pathogenic PMS2 P54278 Y318S 318 Y S 0.168 Neutral PMS2 P54278 Y318T 318 Y T 0.184 Neutral PMS2 P54278 Y318V 318 Y V 0.488 Neutral PMS2 P54278 Y318W 318 Y W 0.392 Neutral PMS2 P54278 P319A 319 P A 0.838 Pathogenic PMS2 P54278 P319C 319 P C 0.2 Neutral PMS2 P54278 P319D 319 P D 0.406 Neutral PMS2 P54278 P319E 319 P E 0.978 Pathogenic PMS2 P54278 P319F 319 P F 0.996 Pathogenic PMS2 P54278 P319G 319 P G 0.526 Pathogenic PMS2 P54278 P319H 319 P H 0.51 Pathogenic PMS2 P54278 P319I 319 P I 0.92 Pathogenic PMS2 P54278 P319K 319 P K 0.966 Pathogenic PMS2 P54278 P319L 319 P L 0.672 Pathogenic PMS2 P54278 P319M 319 P M 0.97 Pathogenic PMS2 P54278 P319N 319 P N 0.144 Neutral PMS2 P54278 P319Q 319 P Q 0.254 Neutral PMS2 P54278 P319R 319 P R 0.512 Pathogenic PMS2 P54278 P319S 319 P S 0.378 Neutral PMS2 P54278 P319T 319 P T 0.698 Pathogenic PMS2 P54278 P319V 319 P V 0.848 Pathogenic PMS2 P54278 P319W 319 P W 0.938 Pathogenic PMS2 P54278 P319Y 319 P Y 0.934 Pathogenic PMS2 P54278 V32A 32 V A 0.044 Neutral PMS2 P54278 V32C 32 V C 0.038 Neutral PMS2 P54278 V32D 32 V D 0.068 Neutral PMS2 P54278 V32E 32 V E 0.692 Pathogenic PMS2 P54278 V32F 32 V F 0.756 Pathogenic PMS2 P54278 V32G 32 V G 0.624 Pathogenic PMS2 P54278 V32H 32 V H 0.526 Pathogenic PMS2 P54278 V32I 32 V I 0.046 Neutral PMS2 P54278 V32K 32 V K 0.654 Pathogenic PMS2 P54278 V32L 32 V L 0.366 Neutral PMS2 P54278 V32M 32 V M 0.268 Neutral PMS2 P54278 V32N 32 V N 0.088 Neutral PMS2 P54278 V32P 32 V P 0.858 Pathogenic PMS2 P54278 V32Q 32 V Q 0.706 Pathogenic PMS2 P54278 V32R 32 V R 0.602 Pathogenic PMS2 P54278 V32S 32 V S 0.042 Neutral PMS2 P54278 V32T 32 V T 0.37 Neutral PMS2 P54278 V32W 32 V W 0.832 Pathogenic PMS2 P54278 V32Y 32 V Y 0.824 Pathogenic PMS2 P54278 F320A 320 F A 0.222 Neutral PMS2 P54278 F320C 320 F C 0.068 Neutral PMS2 P54278 F320D 320 F D 0.564 Pathogenic PMS2 P54278 F320E 320 F E 0.662 Pathogenic PMS2 P54278 F320G 320 F G 0.354 Neutral PMS2 P54278 F320H 320 F H 0.37 Neutral PMS2 P54278 F320I 320 F I 0.056 Neutral PMS2 P54278 F320K 320 F K 0.612 Pathogenic PMS2 P54278 F320L 320 F L 0.028 Neutral PMS2 P54278 F320M 320 F M 0.042 Neutral PMS2 P54278 F320N 320 F N 0.55 Pathogenic PMS2 P54278 F320P 320 F P 0.712 Pathogenic PMS2 P54278 F320Q 320 F Q 0.452 Neutral PMS2 P54278 F320R 320 F R 0.654 Pathogenic PMS2 P54278 F320S 320 F S 0.352 Neutral PMS2 P54278 F320T 320 F T 0.15 Neutral PMS2 P54278 F320V 320 F V 0.03 Neutral PMS2 P54278 F320W 320 F W 0.818 Pathogenic PMS2 P54278 F320Y 320 F Y 0.492 Neutral PMS2 P54278 V321A 321 V A 0.012 Neutral PMS2 P54278 V321C 321 V C 0.336 Neutral PMS2 P54278 V321D 321 V D 0.554 Pathogenic PMS2 P54278 V321E 321 V E 0.668 Pathogenic PMS2 P54278 V321F 321 V F 0.446 Neutral PMS2 P54278 V321G 321 V G 0.078 Neutral PMS2 P54278 V321H 321 V H 0.504 Pathogenic PMS2 P54278 V321I 321 V I 0.052 Neutral PMS2 P54278 V321K 321 V K 0.65 Pathogenic PMS2 P54278 V321L 321 V L 0.072 Neutral PMS2 P54278 V321M 321 V M 0.448 Neutral PMS2 P54278 V321N 321 V N 0.232 Neutral PMS2 P54278 V321P 321 V P 0.826 Pathogenic PMS2 P54278 V321Q 321 V Q 0.682 Pathogenic PMS2 P54278 V321R 321 V R 0.832 Pathogenic PMS2 P54278 V321S 321 V S 0.036 Neutral PMS2 P54278 V321T 321 V T 0.022 Neutral PMS2 P54278 V321W 321 V W 0.818 Pathogenic PMS2 P54278 V321Y 321 V Y 0.666 Pathogenic PMS2 P54278 V322A 322 V A 0.036 Neutral PMS2 P54278 V322C 322 V C 0.318 Neutral PMS2 P54278 V322D 322 V D 0.08 Neutral PMS2 P54278 V322E 322 V E 0.12 Neutral PMS2 P54278 V322F 322 V F 0.384 Neutral PMS2 P54278 V322G 322 V G 0.112 Neutral PMS2 P54278 V322H 322 V H 0.428 Neutral PMS2 P54278 V322I 322 V I 0.03 Neutral PMS2 P54278 V322K 322 V K 0.646 Pathogenic PMS2 P54278 V322L 322 V L 0.03 Neutral PMS2 P54278 V322M 322 V M 0.056 Neutral PMS2 P54278 V322N 322 V N 0.592 Pathogenic PMS2 P54278 V322P 322 V P 0.714 Pathogenic PMS2 P54278 V322Q 322 V Q 0.122 Neutral PMS2 P54278 V322R 322 V R 0.752 Pathogenic PMS2 P54278 V322S 322 V S 0.364 Neutral PMS2 P54278 V322T 322 V T 0.04 Neutral PMS2 P54278 V322W 322 V W 0.722 Pathogenic PMS2 P54278 V322Y 322 V Y 0.376 Neutral PMS2 P54278 L323A 323 L A 0.1 Neutral PMS2 P54278 L323C 323 L C 0.27 Neutral PMS2 P54278 L323D 323 L D 0.914 Pathogenic PMS2 P54278 L323E 323 L E 0.892 Pathogenic PMS2 P54278 L323F 323 L F 0.46 Neutral PMS2 P54278 L323G 323 L G 0.804 Pathogenic PMS2 P54278 L323H 323 L H 0.772 Pathogenic PMS2 P54278 L323I 323 L I 0.124 Neutral PMS2 P54278 L323K 323 L K 0.694 Pathogenic PMS2 P54278 L323M 323 L M 0.152 Neutral PMS2 P54278 L323N 323 L N 0.786 Pathogenic PMS2 P54278 L323P 323 L P 0.972 Pathogenic PMS2 P54278 L323Q 323 L Q 0.606 Pathogenic PMS2 P54278 L323R 323 L R 0.722 Pathogenic PMS2 P54278 L323S 323 L S 0.578 Pathogenic PMS2 P54278 L323T 323 L T 0.32 Neutral PMS2 P54278 L323V 323 L V 0.3 Neutral PMS2 P54278 L323W 323 L W 0.868 Pathogenic PMS2 P54278 L323Y 323 L Y 0.828 Pathogenic PMS2 P54278 N324A 324 N A 0.538 Pathogenic PMS2 P54278 N324C 324 N C 0.59 Pathogenic PMS2 P54278 N324D 324 N D 0.036 Neutral PMS2 P54278 N324E 324 N E 0.044 Neutral PMS2 P54278 N324F 324 N F 0.508 Pathogenic PMS2 P54278 N324G 324 N G 0.436 Neutral PMS2 P54278 N324H 324 N H 0.374 Neutral PMS2 P54278 N324I 324 N I 0.902 Pathogenic PMS2 P54278 N324K 324 N K 0.086 Neutral PMS2 P54278 N324L 324 N L 0.8 Pathogenic PMS2 P54278 N324M 324 N M 0.872 Pathogenic PMS2 P54278 N324P 324 N P 0.75 Pathogenic PMS2 P54278 N324Q 324 N Q 0.056 Neutral PMS2 P54278 N324R 324 N R 0.468 Neutral PMS2 P54278 N324S 324 N S 0.232 Neutral PMS2 P54278 N324T 324 N T 0.552 Pathogenic PMS2 P54278 N324V 324 N V 0.432 Neutral PMS2 P54278 N324W 324 N W 0.946 Pathogenic PMS2 P54278 N324Y 324 N Y 0.934 Pathogenic PMS2 P54278 I325A 325 I A 0.124 Neutral PMS2 P54278 I325C 325 I C 0.364 Neutral PMS2 P54278 I325D 325 I D 0.588 Pathogenic PMS2 P54278 I325E 325 I E 0.524 Pathogenic PMS2 P54278 I325F 325 I F 0.154 Neutral PMS2 P54278 I325G 325 I G 0.54 Pathogenic PMS2 P54278 I325H 325 I H 0.056 Neutral PMS2 P54278 I325K 325 I K 0.092 Neutral PMS2 P54278 I325L 325 I L 0.018 Neutral PMS2 P54278 I325M 325 I M 0.444 Neutral PMS2 P54278 I325N 325 I N 0.162 Neutral PMS2 P54278 I325P 325 I P 0.636 Pathogenic PMS2 P54278 I325Q 325 I Q 0.154 Neutral PMS2 P54278 I325R 325 I R 0.786 Pathogenic PMS2 P54278 I325S 325 I S 0.118 Neutral PMS2 P54278 I325T 325 I T 0.332 Neutral PMS2 P54278 I325V 325 I V 0.02 Neutral PMS2 P54278 I325W 325 I W 0.848 Pathogenic PMS2 P54278 I325Y 325 I Y 0.846 Pathogenic PMS2 P54278 S326A 326 S A 0.03 Neutral PMS2 P54278 S326C 326 S C 0.022 Neutral PMS2 P54278 S326D 326 S D 0.044 Neutral PMS2 P54278 S326E 326 S E 0.376 Neutral PMS2 P54278 S326F 326 S F 0.73 Pathogenic PMS2 P54278 S326G 326 S G 0.272 Neutral PMS2 P54278 S326H 326 S H 0.408 Neutral PMS2 P54278 S326I 326 S I 0.274 Neutral PMS2 P54278 S326K 326 S K 0.374 Neutral PMS2 P54278 S326L 326 S L 0.314 Neutral PMS2 P54278 S326M 326 S M 0.682 Pathogenic PMS2 P54278 S326N 326 S N 0.042 Neutral PMS2 P54278 S326P 326 S P 0.142 Neutral PMS2 P54278 S326Q 326 S Q 0.412 Neutral PMS2 P54278 S326R 326 S R 0.398 Neutral PMS2 P54278 S326T 326 S T 0.036 Neutral PMS2 P54278 S326V 326 S V 0.072 Neutral PMS2 P54278 S326W 326 S W 0.904 Pathogenic PMS2 P54278 S326Y 326 S Y 0.878 Pathogenic PMS2 P54278 V327A 327 V A 0.024 Neutral PMS2 P54278 V327C 327 V C 0.244 Neutral PMS2 P54278 V327D 327 V D 0.602 Pathogenic PMS2 P54278 V327E 327 V E 0.706 Pathogenic PMS2 P54278 V327F 327 V F 0.764 Pathogenic PMS2 P54278 V327G 327 V G 0.628 Pathogenic PMS2 P54278 V327H 327 V H 0.544 Pathogenic PMS2 P54278 V327I 327 V I 0.054 Neutral PMS2 P54278 V327K 327 V K 0.79 Pathogenic PMS2 P54278 V327L 327 V L 0.05 Neutral PMS2 P54278 V327M 327 V M 0.076 Neutral PMS2 P54278 V327N 327 V N 0.638 Pathogenic PMS2 P54278 V327P 327 V P 0.86 Pathogenic PMS2 P54278 V327Q 327 V Q 0.72 Pathogenic PMS2 P54278 V327R 327 V R 0.838 Pathogenic PMS2 P54278 V327S 327 V S 0.078 Neutral PMS2 P54278 V327T 327 V T 0.026 Neutral PMS2 P54278 V327W 327 V W 0.5 Pathogenic PMS2 P54278 V327Y 327 V Y 0.83 Pathogenic PMS2 P54278 D328A 328 D A 0.104 Neutral PMS2 P54278 D328C 328 D C 0.412 Neutral PMS2 P54278 D328E 328 D E 0.068 Neutral PMS2 P54278 D328F 328 D F 0.928 Pathogenic PMS2 P54278 D328G 328 D G 0.478 Neutral PMS2 P54278 D328H 328 D H 0.18 Neutral PMS2 P54278 D328I 328 D I 0.888 Pathogenic PMS2 P54278 D328K 328 D K 0.078 Neutral PMS2 P54278 D328L 328 D L 0.888 Pathogenic PMS2 P54278 D328M 328 D M 0.804 Pathogenic PMS2 P54278 D328N 328 D N 0.052 Neutral PMS2 P54278 D328P 328 D P 0.098 Neutral PMS2 P54278 D328Q 328 D Q 0.03 Neutral PMS2 P54278 D328R 328 D R 0.476 Neutral PMS2 P54278 D328S 328 D S 0.028 Neutral PMS2 P54278 D328T 328 D T 0.14 Neutral PMS2 P54278 D328V 328 D V 0.824 Pathogenic PMS2 P54278 D328W 328 D W 0.97 Pathogenic PMS2 P54278 D328Y 328 D Y 0.964 Pathogenic PMS2 P54278 S329A 329 S A 0.138 Neutral PMS2 P54278 S329C 329 S C 0.1 Neutral PMS2 P54278 S329D 329 S D 0.37 Neutral PMS2 P54278 S329E 329 S E 0.738 Pathogenic PMS2 P54278 S329F 329 S F 0.886 Pathogenic PMS2 P54278 S329G 329 S G 0.032 Neutral PMS2 P54278 S329H 329 S H 0.674 Pathogenic PMS2 P54278 S329I 329 S I 0.602 Pathogenic PMS2 P54278 S329K 329 S K 0.46 Neutral PMS2 P54278 S329L 329 S L 0.36 Neutral PMS2 P54278 S329M 329 S M 0.724 Pathogenic PMS2 P54278 S329N 329 S N 0.28 Neutral PMS2 P54278 S329P 329 S P 0.158 Neutral PMS2 P54278 S329Q 329 S Q 0.544 Pathogenic PMS2 P54278 S329R 329 S R 0.468 Neutral PMS2 P54278 S329T 329 S T 0.054 Neutral PMS2 P54278 S329V 329 S V 0.796 Pathogenic PMS2 P54278 S329W 329 S W 0.948 Pathogenic PMS2 P54278 S329Y 329 S Y 0.928 Pathogenic PMS2 P54278 L33A 33 L A 0.148 Neutral PMS2 P54278 L33C 33 L C 0.368 Neutral PMS2 P54278 L33D 33 L D 0.646 Pathogenic PMS2 P54278 L33E 33 L E 0.118 Neutral PMS2 P54278 L33F 33 L F 0.278 Neutral PMS2 P54278 L33G 33 L G 0.568 Pathogenic PMS2 P54278 L33H 33 L H 0.164 Neutral PMS2 P54278 L33I 33 L I 0.056 Neutral PMS2 P54278 L33K 33 L K 0.454 Neutral PMS2 P54278 L33M 33 L M 0.46 Neutral PMS2 P54278 L33N 33 L N 0.596 Pathogenic PMS2 P54278 L33P 33 L P 0.188 Neutral PMS2 P54278 L33Q 33 L Q 0.334 Neutral PMS2 P54278 L33R 33 L R 0.764 Pathogenic PMS2 P54278 L33S 33 L S 0.438 Neutral PMS2 P54278 L33T 33 L T 0.092 Neutral PMS2 P54278 L33V 33 L V 0.004 Neutral PMS2 P54278 L33W 33 L W 0.866 Pathogenic PMS2 P54278 L33Y 33 L Y 0.862 Pathogenic PMS2 P54278 E330A 330 E A 0.194 Neutral PMS2 P54278 E330C 330 E C 0.396 Neutral PMS2 P54278 E330D 330 E D 0.01 Neutral PMS2 P54278 E330F 330 E F 0.796 Pathogenic PMS2 P54278 E330G 330 E G 0.016 Neutral PMS2 P54278 E330H 330 E H 0.04 Neutral PMS2 P54278 E330I 330 E I 0.86 Pathogenic PMS2 P54278 E330K 330 E K 0.152 Neutral PMS2 P54278 E330L 330 E L 0.844 Pathogenic PMS2 P54278 E330M 330 E M 0.656 Pathogenic PMS2 P54278 E330N 330 E N 0.008 Neutral PMS2 P54278 E330P 330 E P 0.27 Neutral PMS2 P54278 E330Q 330 E Q 0.01 Neutral PMS2 P54278 E330R 330 E R 0.084 Neutral PMS2 P54278 E330S 330 E S 0.032 Neutral PMS2 P54278 E330T 330 E T 0.028 Neutral PMS2 P54278 E330V 330 E V 0.816 Pathogenic PMS2 P54278 E330W 330 E W 0.934 Pathogenic PMS2 P54278 E330Y 330 E Y 0.86 Pathogenic PMS2 P54278 C331A 331 C A 0.008 Neutral PMS2 P54278 C331D 331 C D 0.014 Neutral PMS2 P54278 C331E 331 C E 0.04 Neutral PMS2 P54278 C331F 331 C F 0.652 Pathogenic PMS2 P54278 C331G 331 C G 0.22 Neutral PMS2 P54278 C331H 331 C H 0.39 Neutral PMS2 P54278 C331I 331 C I 0.422 Neutral PMS2 P54278 C331K 331 C K 0.158 Neutral PMS2 P54278 C331L 331 C L 0.044 Neutral PMS2 P54278 C331M 331 C M 0.034 Neutral PMS2 P54278 C331N 331 C N 0.038 Neutral PMS2 P54278 C331P 331 C P 0.424 Neutral PMS2 P54278 C331Q 331 C Q 0.208 Neutral PMS2 P54278 C331R 331 C R 0.468 Neutral PMS2 P54278 C331S 331 C S 0.014 Neutral PMS2 P54278 C331T 331 C T 0 Neutral PMS2 P54278 C331V 331 C V 0.132 Neutral PMS2 P54278 C331W 331 C W 0.728 Pathogenic PMS2 P54278 C331Y 331 C Y 0.696 Pathogenic PMS2 P54278 V332A 332 V A 0.042 Neutral PMS2 P54278 V332C 332 V C 0.05 Neutral PMS2 P54278 V332D 332 V D 0.52 Pathogenic PMS2 P54278 V332E 332 V E 0.626 Pathogenic PMS2 P54278 V332F 332 V F 0.402 Neutral PMS2 P54278 V332G 332 V G 0.612 Pathogenic PMS2 P54278 V332H 332 V H 0.428 Neutral PMS2 P54278 V332I 332 V I 0.03 Neutral PMS2 P54278 V332K 332 V K 0.636 Pathogenic PMS2 P54278 V332L 332 V L 0.314 Neutral PMS2 P54278 V332M 332 V M 0.364 Neutral PMS2 P54278 V332N 332 V N 0.56 Pathogenic PMS2 P54278 V332P 332 V P 0.714 Pathogenic PMS2 P54278 V332Q 332 V Q 0.648 Pathogenic PMS2 P54278 V332R 332 V R 0.764 Pathogenic PMS2 P54278 V332S 332 V S 0.376 Neutral PMS2 P54278 V332T 332 V T 0.158 Neutral PMS2 P54278 V332W 332 V W 0.722 Pathogenic PMS2 P54278 V332Y 332 V Y 0.382 Neutral PMS2 P54278 D333A 333 D A 0.508 Pathogenic PMS2 P54278 D333C 333 D C 0.668 Pathogenic PMS2 P54278 D333E 333 D E 0.608 Pathogenic PMS2 P54278 D333F 333 D F 0.904 Pathogenic PMS2 P54278 D333G 333 D G 0.45 Neutral PMS2 P54278 D333H 333 D H 0.358 Neutral PMS2 P54278 D333I 333 D I 0.862 Pathogenic PMS2 P54278 D333K 333 D K 0.698 Pathogenic PMS2 P54278 D333L 333 D L 0.852 Pathogenic PMS2 P54278 D333M 333 D M 0.766 Pathogenic PMS2 P54278 D333N 333 D N 0.412 Neutral PMS2 P54278 D333P 333 D P 0.75 Pathogenic PMS2 P54278 D333Q 333 D Q 0.45 Neutral PMS2 P54278 D333R 333 D R 0.77 Pathogenic PMS2 P54278 D333S 333 D S 0.414 Neutral PMS2 P54278 D333T 333 D T 0.518 Pathogenic PMS2 P54278 D333V 333 D V 0.882 Pathogenic PMS2 P54278 D333W 333 D W 0.936 Pathogenic PMS2 P54278 D333Y 333 D Y 0.924 Pathogenic PMS2 P54278 I334A 334 I A 0.246 Neutral PMS2 P54278 I334C 334 I C 0.386 Neutral PMS2 P54278 I334D 334 I D 0.572 Pathogenic PMS2 P54278 I334E 334 I E 0.554 Pathogenic PMS2 P54278 I334F 334 I F 0.686 Pathogenic PMS2 P54278 I334G 334 I G 0.554 Pathogenic PMS2 P54278 I334H 334 I H 0.438 Neutral PMS2 P54278 I334K 334 I K 0.568 Pathogenic PMS2 P54278 I334L 334 I L 0.018 Neutral PMS2 P54278 I334M 334 I M 0.386 Neutral PMS2 P54278 I334N 334 I N 0.616 Pathogenic PMS2 P54278 I334P 334 I P 0.702 Pathogenic PMS2 P54278 I334Q 334 I Q 0.592 Pathogenic PMS2 P54278 I334R 334 I R 0.824 Pathogenic PMS2 P54278 I334S 334 I S 0.42 Neutral PMS2 P54278 I334T 334 I T 0.34 Neutral PMS2 P54278 I334V 334 I V 0.154 Neutral PMS2 P54278 I334W 334 I W 0.898 Pathogenic PMS2 P54278 I334Y 334 I Y 0.904 Pathogenic PMS2 P54278 N335A 335 N A 0.738 Pathogenic PMS2 P54278 N335C 335 N C 0.802 Pathogenic PMS2 P54278 N335D 335 N D 0.854 Pathogenic PMS2 P54278 N335E 335 N E 0.74 Pathogenic PMS2 P54278 N335F 335 N F 0.966 Pathogenic PMS2 P54278 N335G 335 N G 0.89 Pathogenic PMS2 P54278 N335H 335 N H 0.482 Neutral PMS2 P54278 N335I 335 N I 0.948 Pathogenic PMS2 P54278 N335K 335 N K 0.986 Pathogenic PMS2 P54278 N335L 335 N L 0.966 Pathogenic PMS2 P54278 N335M 335 N M 0.972 Pathogenic PMS2 P54278 N335P 335 N P 0.896 Pathogenic PMS2 P54278 N335Q 335 N Q 0.966 Pathogenic PMS2 P54278 N335R 335 N R 0.924 Pathogenic PMS2 P54278 N335S 335 N S 0.944 Pathogenic PMS2 P54278 N335T 335 N T 0.686 Pathogenic PMS2 P54278 N335V 335 N V 0.99 Pathogenic PMS2 P54278 N335W 335 N W 0.978 Pathogenic PMS2 P54278 N335Y 335 N Y 0.974 Pathogenic PMS2 P54278 V336A 336 V A 0.332 Neutral PMS2 P54278 V336C 336 V C 0.712 Pathogenic PMS2 P54278 V336D 336 V D 0.864 Pathogenic PMS2 P54278 V336E 336 V E 0.982 Pathogenic PMS2 P54278 V336F 336 V F 0.876 Pathogenic PMS2 P54278 V336G 336 V G 0.242 Neutral PMS2 P54278 V336H 336 V H 0.82 Pathogenic PMS2 P54278 V336I 336 V I 0.234 Neutral PMS2 P54278 V336K 336 V K 0.99 Pathogenic PMS2 P54278 V336L 336 V L 0.194 Neutral PMS2 P54278 V336M 336 V M 0.82 Pathogenic PMS2 P54278 V336N 336 V N 0.924 Pathogenic PMS2 P54278 V336P 336 V P 0.984 Pathogenic PMS2 P54278 V336Q 336 V Q 0.988 Pathogenic PMS2 P54278 V336R 336 V R 0.956 Pathogenic PMS2 P54278 V336S 336 V S 0.724 Pathogenic PMS2 P54278 V336T 336 V T 0.746 Pathogenic PMS2 P54278 V336W 336 V W 0.904 Pathogenic PMS2 P54278 V336Y 336 V Y 0.928 Pathogenic PMS2 P54278 T337A 337 T A 0.136 Neutral PMS2 P54278 T337C 337 T C 0.806 Pathogenic PMS2 P54278 T337D 337 T D 0.82 Pathogenic PMS2 P54278 T337E 337 T E 0.888 Pathogenic PMS2 P54278 T337F 337 T F 0.906 Pathogenic PMS2 P54278 T337G 337 T G 0.57 Pathogenic PMS2 P54278 T337H 337 T H 0.832 Pathogenic PMS2 P54278 T337I 337 T I 0.868 Pathogenic PMS2 P54278 T337K 337 T K 0.846 Pathogenic PMS2 P54278 T337L 337 T L 0.854 Pathogenic PMS2 P54278 T337M 337 T M 0.944 Pathogenic PMS2 P54278 T337N 337 T N 0.734 Pathogenic PMS2 P54278 T337P 337 T P 0.898 Pathogenic PMS2 P54278 T337Q 337 T Q 0.744 Pathogenic PMS2 P54278 T337R 337 T R 0.522 Pathogenic PMS2 P54278 T337S 337 T S 0.072 Neutral PMS2 P54278 T337V 337 T V 0.706 Pathogenic PMS2 P54278 T337W 337 T W 0.98 Pathogenic PMS2 P54278 T337Y 337 T Y 0.98 Pathogenic PMS2 P54278 P338A 338 P A 0.834 Pathogenic PMS2 P54278 P338C 338 P C 0.92 Pathogenic PMS2 P54278 P338D 338 P D 0.87 Pathogenic PMS2 P54278 P338E 338 P E 0.962 Pathogenic PMS2 P54278 P338F 338 P F 1 Pathogenic PMS2 P54278 P338G 338 P G 0.696 Pathogenic PMS2 P54278 P338H 338 P H 0.98 Pathogenic PMS2 P54278 P338I 338 P I 0.934 Pathogenic PMS2 P54278 P338K 338 P K 0.952 Pathogenic PMS2 P54278 P338L 338 P L 0.998 Pathogenic PMS2 P54278 P338M 338 P M 0.962 Pathogenic PMS2 P54278 P338N 338 P N 0.79 Pathogenic PMS2 P54278 P338Q 338 P Q 0.884 Pathogenic PMS2 P54278 P338R 338 P R 0.988 Pathogenic PMS2 P54278 P338S 338 P S 0.342 Neutral PMS2 P54278 P338T 338 P T 0.746 Pathogenic PMS2 P54278 P338V 338 P V 0.85 Pathogenic PMS2 P54278 P338W 338 P W 0.936 Pathogenic PMS2 P54278 P338Y 338 P Y 0.93 Pathogenic PMS2 P54278 D339A 339 D A 0.718 Pathogenic PMS2 P54278 D339C 339 D C 0.92 Pathogenic PMS2 P54278 D339E 339 D E 0.972 Pathogenic PMS2 P54278 D339F 339 D F 0.984 Pathogenic PMS2 P54278 D339G 339 D G 0.922 Pathogenic PMS2 P54278 D339H 339 D H 0.652 Pathogenic PMS2 P54278 D339I 339 D I 0.97 Pathogenic PMS2 P54278 D339K 339 D K 0.984 Pathogenic PMS2 P54278 D339L 339 D L 0.98 Pathogenic PMS2 P54278 D339M 339 D M 0.962 Pathogenic PMS2 P54278 D339N 339 D N 0.178 Neutral PMS2 P54278 D339P 339 D P 0.914 Pathogenic PMS2 P54278 D339Q 339 D Q 0.768 Pathogenic PMS2 P54278 D339R 339 D R 0.916 Pathogenic PMS2 P54278 D339S 339 D S 0.714 Pathogenic PMS2 P54278 D339T 339 D T 0.27 Neutral PMS2 P54278 D339V 339 D V 0.992 Pathogenic PMS2 P54278 D339W 339 D W 0.986 Pathogenic PMS2 P54278 D339Y 339 D Y 0.98 Pathogenic PMS2 P54278 S34A 34 S A 0.178 Neutral PMS2 P54278 S34C 34 S C 0.3 Neutral PMS2 P54278 S34D 34 S D 0.088 Neutral PMS2 P54278 S34E 34 S E 0.438 Neutral PMS2 P54278 S34F 34 S F 0.83 Pathogenic PMS2 P54278 S34G 34 S G 0.038 Neutral PMS2 P54278 S34H 34 S H 0.744 Pathogenic PMS2 P54278 S34I 34 S I 0.574 Pathogenic PMS2 P54278 S34K 34 S K 0.68 Pathogenic PMS2 P54278 S34L 34 S L 0.552 Pathogenic PMS2 P54278 S34M 34 S M 0.934 Pathogenic PMS2 P54278 S34N 34 S N 0.042 Neutral PMS2 P54278 S34P 34 S P 0.566 Pathogenic PMS2 P54278 S34Q 34 S Q 0.528 Pathogenic PMS2 P54278 S34R 34 S R 0.658 Pathogenic PMS2 P54278 S34T 34 S T 0.052 Neutral PMS2 P54278 S34V 34 S V 0.244 Neutral PMS2 P54278 S34W 34 S W 0.928 Pathogenic PMS2 P54278 S34Y 34 S Y 0.902 Pathogenic PMS2 P54278 K340A 340 K A 0.546 Pathogenic PMS2 P54278 K340C 340 K C 0.434 Neutral PMS2 P54278 K340D 340 K D 0.612 Pathogenic PMS2 P54278 K340E 340 K E 0.728 Pathogenic PMS2 P54278 K340F 340 K F 0.854 Pathogenic PMS2 P54278 K340G 340 K G 0.532 Pathogenic PMS2 P54278 K340H 340 K H 0.75 Pathogenic PMS2 P54278 K340I 340 K I 0.314 Neutral PMS2 P54278 K340L 340 K L 0.694 Pathogenic PMS2 P54278 K340M 340 K M 0.27 Neutral PMS2 P54278 K340N 340 K N 0.658 Pathogenic PMS2 P54278 K340P 340 K P 0.918 Pathogenic PMS2 P54278 K340Q 340 K Q 0.736 Pathogenic PMS2 P54278 K340R 340 K R 0.744 Pathogenic PMS2 P54278 K340S 340 K S 0.702 Pathogenic PMS2 P54278 K340T 340 K T 0.616 Pathogenic PMS2 P54278 K340V 340 K V 0.876 Pathogenic PMS2 P54278 K340W 340 K W 0.992 Pathogenic PMS2 P54278 K340Y 340 K Y 0.986 Pathogenic PMS2 P54278 R341A 341 R A 0.566 Pathogenic PMS2 P54278 R341C 341 R C 0.95 Pathogenic PMS2 P54278 R341D 341 R D 0.676 Pathogenic PMS2 P54278 R341E 341 R E 0.776 Pathogenic PMS2 P54278 R341F 341 R F 0.966 Pathogenic PMS2 P54278 R341G 341 R G 0.158 Neutral PMS2 P54278 R341H 341 R H 0.354 Neutral PMS2 P54278 R341I 341 R I 0.974 Pathogenic PMS2 P54278 R341K 341 R K 0.49 Neutral PMS2 P54278 R341L 341 R L 0.484 Neutral PMS2 P54278 R341M 341 R M 0.77 Pathogenic PMS2 P54278 R341N 341 R N 0.634 Pathogenic PMS2 P54278 R341P 341 R P 0.986 Pathogenic PMS2 P54278 R341Q 341 R Q 0.486 Neutral PMS2 P54278 R341S 341 R S 0.91 Pathogenic PMS2 P54278 R341T 341 R T 0.934 Pathogenic PMS2 P54278 R341V 341 R V 0.974 Pathogenic PMS2 P54278 R341W 341 R W 0.95 Pathogenic PMS2 P54278 R341Y 341 R Y 0.954 Pathogenic PMS2 P54278 Q342A 342 Q A 0.538 Pathogenic PMS2 P54278 Q342C 342 Q C 0.492 Neutral PMS2 P54278 Q342D 342 Q D 0.554 Pathogenic PMS2 P54278 Q342E 342 Q E 0.552 Pathogenic PMS2 P54278 Q342F 342 Q F 0.846 Pathogenic PMS2 P54278 Q342G 342 Q G 0.456 Neutral PMS2 P54278 Q342H 342 Q H 0.23 Neutral PMS2 P54278 Q342I 342 Q I 0.898 Pathogenic PMS2 P54278 Q342K 342 Q K 0.048 Neutral PMS2 P54278 Q342L 342 Q L 0.754 Pathogenic PMS2 P54278 Q342M 342 Q M 0.184 Neutral PMS2 P54278 Q342N 342 Q N 0.602 Pathogenic PMS2 P54278 Q342P 342 Q P 0.848 Pathogenic PMS2 P54278 Q342R 342 Q R 0.396 Neutral PMS2 P54278 Q342S 342 Q S 0.108 Neutral PMS2 P54278 Q342T 342 Q T 0.02 Neutral PMS2 P54278 Q342V 342 Q V 0.708 Pathogenic PMS2 P54278 Q342W 342 Q W 0.92 Pathogenic PMS2 P54278 Q342Y 342 Q Y 0.89 Pathogenic PMS2 P54278 I343A 343 I A 0.212 Neutral PMS2 P54278 I343C 343 I C 0.634 Pathogenic PMS2 P54278 I343D 343 I D 0.782 Pathogenic PMS2 P54278 I343E 343 I E 0.786 Pathogenic PMS2 P54278 I343F 343 I F 0.944 Pathogenic PMS2 P54278 I343G 343 I G 0.82 Pathogenic PMS2 P54278 I343H 343 I H 0.852 Pathogenic PMS2 P54278 I343K 343 I K 0.858 Pathogenic PMS2 P54278 I343L 343 I L 0.218 Neutral PMS2 P54278 I343M 343 I M 0.218 Neutral PMS2 P54278 I343N 343 I N 0.804 Pathogenic PMS2 P54278 I343P 343 I P 0.93 Pathogenic PMS2 P54278 I343Q 343 I Q 0.812 Pathogenic PMS2 P54278 I343R 343 I R 0.892 Pathogenic PMS2 P54278 I343S 343 I S 0.62 Pathogenic PMS2 P54278 I343T 343 I T 0.372 Neutral PMS2 P54278 I343V 343 I V 0.126 Neutral PMS2 P54278 I343W 343 I W 0.964 Pathogenic PMS2 P54278 I343Y 343 I Y 0.958 Pathogenic PMS2 P54278 L344A 344 L A 0.036 Neutral PMS2 P54278 L344C 344 L C 0.024 Neutral PMS2 P54278 L344D 344 L D 0.608 Pathogenic PMS2 P54278 L344E 344 L E 0.562 Pathogenic PMS2 P54278 L344F 344 L F 0.32 Neutral PMS2 P54278 L344G 344 L G 0.536 Pathogenic PMS2 P54278 L344H 344 L H 0.156 Neutral PMS2 P54278 L344I 344 L I 0.036 Neutral PMS2 P54278 L344K 344 L K 0.436 Neutral PMS2 P54278 L344M 344 L M 0.018 Neutral PMS2 P54278 L344N 344 L N 0.562 Pathogenic PMS2 P54278 L344P 344 L P 0.914 Pathogenic PMS2 P54278 L344Q 344 L Q 0.3 Neutral PMS2 P54278 L344R 344 L R 0.856 Pathogenic PMS2 P54278 L344S 344 L S 0.44 Neutral PMS2 P54278 L344T 344 L T 0.37 Neutral PMS2 P54278 L344V 344 L V 0.004 Neutral PMS2 P54278 L344W 344 L W 0.832 Pathogenic PMS2 P54278 L344Y 344 L Y 0.758 Pathogenic PMS2 P54278 L345A 345 L A 0.186 Neutral PMS2 P54278 L345C 345 L C 0.09 Neutral PMS2 P54278 L345D 345 L D 0.1 Neutral PMS2 P54278 L345E 345 L E 0.54 Pathogenic PMS2 P54278 L345F 345 L F 0.296 Neutral PMS2 P54278 L345G 345 L G 0.152 Neutral PMS2 P54278 L345H 345 L H 0.314 Neutral PMS2 P54278 L345I 345 L I 0.08 Neutral PMS2 P54278 L345K 345 L K 0.428 Neutral PMS2 P54278 L345M 345 L M 0.04 Neutral PMS2 P54278 L345N 345 L N 0.1 Neutral PMS2 P54278 L345P 345 L P 0.872 Pathogenic PMS2 P54278 L345Q 345 L Q 0.142 Neutral PMS2 P54278 L345R 345 L R 0.636 Pathogenic PMS2 P54278 L345S 345 L S 0.066 Neutral PMS2 P54278 L345T 345 L T 0.264 Neutral PMS2 P54278 L345V 345 L V 0.022 Neutral PMS2 P54278 L345W 345 L W 0.852 Pathogenic PMS2 P54278 L345Y 345 L Y 0.882 Pathogenic PMS2 P54278 Q346A 346 Q A 0.492 Neutral PMS2 P54278 Q346C 346 Q C 0.444 Neutral PMS2 P54278 Q346D 346 Q D 0.456 Neutral PMS2 P54278 Q346E 346 Q E 0.052 Neutral PMS2 P54278 Q346F 346 Q F 0.566 Pathogenic PMS2 P54278 Q346G 346 Q G 0.436 Neutral PMS2 P54278 Q346H 346 Q H 0.078 Neutral PMS2 P54278 Q346I 346 Q I 0.346 Neutral PMS2 P54278 Q346K 346 Q K 0.414 Neutral PMS2 P54278 Q346L 346 Q L 0.236 Neutral PMS2 P54278 Q346M 346 Q M 0.414 Neutral PMS2 P54278 Q346N 346 Q N 0.108 Neutral PMS2 P54278 Q346P 346 Q P 0.842 Pathogenic PMS2 P54278 Q346R 346 Q R 0.474 Neutral PMS2 P54278 Q346S 346 Q S 0.1 Neutral PMS2 P54278 Q346T 346 Q T 0.046 Neutral PMS2 P54278 Q346V 346 Q V 0.14 Neutral PMS2 P54278 Q346W 346 Q W 0.9 Pathogenic PMS2 P54278 Q346Y 346 Q Y 0.908 Pathogenic PMS2 P54278 E347A 347 E A 0.112 Neutral PMS2 P54278 E347C 347 E C 0.208 Neutral PMS2 P54278 E347D 347 E D 0.004 Neutral PMS2 P54278 E347F 347 E F 0.594 Pathogenic PMS2 P54278 E347G 347 E G 0.014 Neutral PMS2 P54278 E347H 347 E H 0.028 Neutral PMS2 P54278 E347I 347 E I 0.638 Pathogenic PMS2 P54278 E347K 347 E K 0.018 Neutral PMS2 P54278 E347L 347 E L 0.084 Neutral PMS2 P54278 E347M 347 E M 0.446 Neutral PMS2 P54278 E347N 347 E N 0.004 Neutral PMS2 P54278 E347P 347 E P 0.652 Pathogenic PMS2 P54278 E347Q 347 E Q 0.002 Neutral PMS2 P54278 E347R 347 E R 0.034 Neutral PMS2 P54278 E347S 347 E S 0.034 Neutral PMS2 P54278 E347T 347 E T 0.03 Neutral PMS2 P54278 E347V 347 E V 0.596 Pathogenic PMS2 P54278 E347W 347 E W 0.822 Pathogenic PMS2 P54278 E347Y 347 E Y 0.71 Pathogenic PMS2 P54278 E348A 348 E A 0.212 Neutral PMS2 P54278 E348C 348 E C 0.482 Neutral PMS2 P54278 E348D 348 E D 0.52 Pathogenic PMS2 P54278 E348F 348 E F 0.878 Pathogenic PMS2 P54278 E348G 348 E G 0.208 Neutral PMS2 P54278 E348H 348 E H 0.618 Pathogenic PMS2 P54278 E348I 348 E I 0.35 Neutral PMS2 P54278 E348K 348 E K 0.056 Neutral PMS2 P54278 E348L 348 E L 0.112 Neutral PMS2 P54278 E348M 348 E M 0.048 Neutral PMS2 P54278 E348N 348 E N 0.336 Neutral PMS2 P54278 E348P 348 E P 0.886 Pathogenic PMS2 P54278 E348Q 348 E Q 0.012 Neutral PMS2 P54278 E348R 348 E R 0.198 Neutral PMS2 P54278 E348S 348 E S 0.076 Neutral PMS2 P54278 E348T 348 E T 0.05 Neutral PMS2 P54278 E348V 348 E V 0.082 Neutral PMS2 P54278 E348W 348 E W 0.97 Pathogenic PMS2 P54278 E348Y 348 E Y 0.92 Pathogenic PMS2 P54278 K349A 349 K A 0.032 Neutral PMS2 P54278 K349C 349 K C 0.06 Neutral PMS2 P54278 K349D 349 K D 0.058 Neutral PMS2 P54278 K349E 349 K E 0.108 Neutral PMS2 P54278 K349F 349 K F 0.362 Neutral PMS2 P54278 K349G 349 K G 0.048 Neutral PMS2 P54278 K349H 349 K H 0.006 Neutral PMS2 P54278 K349I 349 K I 0.374 Neutral PMS2 P54278 K349L 349 K L 0.314 Neutral PMS2 P54278 K349M 349 K M 0.186 Neutral PMS2 P54278 K349N 349 K N 0.008 Neutral PMS2 P54278 K349P 349 K P 0.394 Neutral PMS2 P54278 K349Q 349 K Q 0.01 Neutral PMS2 P54278 K349R 349 K R 0.006 Neutral PMS2 P54278 K349S 349 K S 0.014 Neutral PMS2 P54278 K349T 349 K T 0.016 Neutral PMS2 P54278 K349V 349 K V 0.298 Neutral PMS2 P54278 K349W 349 K W 0.676 Pathogenic PMS2 P54278 K349Y 349 K Y 0.574 Pathogenic PMS2 P54278 L35A 35 L A 0.19 Neutral PMS2 P54278 L35C 35 L C 0.686 Pathogenic PMS2 P54278 L35D 35 L D 0.248 Neutral PMS2 P54278 L35E 35 L E 0.502 Pathogenic PMS2 P54278 L35F 35 L F 0.936 Pathogenic PMS2 P54278 L35G 35 L G 0.198 Neutral PMS2 P54278 L35H 35 L H 0.334 Neutral PMS2 P54278 L35I 35 L I 0.796 Pathogenic PMS2 P54278 L35K 35 L K 0.724 Pathogenic PMS2 P54278 L35M 35 L M 0.442 Neutral PMS2 P54278 L35N 35 L N 0.16 Neutral PMS2 P54278 L35P 35 L P 0.676 Pathogenic PMS2 P54278 L35Q 35 L Q 0.154 Neutral PMS2 P54278 L35R 35 L R 0.998 Pathogenic PMS2 P54278 L35S 35 L S 0.34 Neutral PMS2 P54278 L35T 35 L T 0.328 Neutral PMS2 P54278 L35V 35 L V 0.304 Neutral PMS2 P54278 L35W 35 L W 0.908 Pathogenic PMS2 P54278 L35Y 35 L Y 0.868 Pathogenic PMS2 P54278 L350A 350 L A 0.014 Neutral PMS2 P54278 L350C 350 L C 0.13 Neutral PMS2 P54278 L350D 350 L D 0.23 Neutral PMS2 P54278 L350E 350 L E 0.048 Neutral PMS2 P54278 L350F 350 L F 0.166 Neutral PMS2 P54278 L350G 350 L G 0.258 Neutral PMS2 P54278 L350H 350 L H 0.018 Neutral PMS2 P54278 L350I 350 L I 0.004 Neutral PMS2 P54278 L350K 350 L K 0.242 Neutral PMS2 P54278 L350M 350 L M 0.23 Neutral PMS2 P54278 L350N 350 L N 0.044 Neutral PMS2 P54278 L350P 350 L P 0.334 Neutral PMS2 P54278 L350Q 350 L Q 0.014 Neutral PMS2 P54278 L350R 350 L R 0.356 Neutral PMS2 P54278 L350S 350 L S 0.02 Neutral PMS2 P54278 L350T 350 L T 0.024 Neutral PMS2 P54278 L350V 350 L V 0.004 Neutral PMS2 P54278 L350W 350 L W 0.526 Pathogenic PMS2 P54278 L350Y 350 L Y 0.394 Neutral PMS2 P54278 L351A 351 L A 0.258 Neutral PMS2 P54278 L351C 351 L C 0.308 Neutral PMS2 P54278 L351D 351 L D 0.58 Pathogenic PMS2 P54278 L351E 351 L E 0.54 Pathogenic PMS2 P54278 L351F 351 L F 0.784 Pathogenic PMS2 P54278 L351G 351 L G 0.526 Pathogenic PMS2 P54278 L351H 351 L H 0.314 Neutral PMS2 P54278 L351I 351 L I 0.076 Neutral PMS2 P54278 L351K 351 L K 0.428 Neutral PMS2 P54278 L351M 351 L M 0.034 Neutral PMS2 P54278 L351N 351 L N 0.548 Pathogenic PMS2 P54278 L351P 351 L P 0.872 Pathogenic PMS2 P54278 L351Q 351 L Q 0.284 Neutral PMS2 P54278 L351R 351 L R 0.834 Pathogenic PMS2 P54278 L351S 351 L S 0.386 Neutral PMS2 P54278 L351T 351 L T 0.366 Neutral PMS2 P54278 L351V 351 L V 0.03 Neutral PMS2 P54278 L351W 351 L W 0.852 Pathogenic PMS2 P54278 L351Y 351 L Y 0.844 Pathogenic PMS2 P54278 L352A 352 L A 0.28 Neutral PMS2 P54278 L352C 352 L C 0.338 Neutral PMS2 P54278 L352D 352 L D 0.604 Pathogenic PMS2 P54278 L352E 352 L E 0.56 Pathogenic PMS2 P54278 L352F 352 L F 0.306 Neutral PMS2 P54278 L352G 352 L G 0.54 Pathogenic PMS2 P54278 L352H 352 L H 0.35 Neutral PMS2 P54278 L352I 352 L I 0.06 Neutral PMS2 P54278 L352K 352 L K 0.438 Neutral PMS2 P54278 L352M 352 L M 0.036 Neutral PMS2 P54278 L352N 352 L N 0.564 Pathogenic PMS2 P54278 L352P 352 L P 0.898 Pathogenic PMS2 P54278 L352Q 352 L Q 0.308 Neutral PMS2 P54278 L352R 352 L R 0.86 Pathogenic PMS2 P54278 L352S 352 L S 0.256 Neutral PMS2 P54278 L352T 352 L T 0.374 Neutral PMS2 P54278 L352V 352 L V 0.022 Neutral PMS2 P54278 L352W 352 L W 0.868 Pathogenic PMS2 P54278 L352Y 352 L Y 0.866 Pathogenic PMS2 P54278 A353C 353 A C 0.33 Neutral PMS2 P54278 A353D 353 A D 0.476 Neutral PMS2 P54278 A353E 353 A E 0.41 Neutral PMS2 P54278 A353F 353 A F 0.522 Pathogenic PMS2 P54278 A353G 353 A G 0.008 Neutral PMS2 P54278 A353H 353 A H 0.364 Neutral PMS2 P54278 A353I 353 A I 0.692 Pathogenic PMS2 P54278 A353K 353 A K 0.616 Pathogenic PMS2 P54278 A353L 353 A L 0.436 Neutral PMS2 P54278 A353M 353 A M 0.512 Pathogenic PMS2 P54278 A353N 353 A N 0.544 Pathogenic PMS2 P54278 A353P 353 A P 0.47 Neutral PMS2 P54278 A353Q 353 A Q 0.366 Neutral PMS2 P54278 A353R 353 A R 0.612 Pathogenic PMS2 P54278 A353S 353 A S 0.008 Neutral PMS2 P54278 A353T 353 A T 0.026 Neutral PMS2 P54278 A353V 353 A V 0.448 Neutral PMS2 P54278 A353W 353 A W 0.778 Pathogenic PMS2 P54278 A353Y 353 A Y 0.782 Pathogenic PMS2 P54278 V354A 354 V A 0.004 Neutral PMS2 P54278 V354C 354 V C 0.084 Neutral PMS2 P54278 V354D 354 V D 0.198 Neutral PMS2 P54278 V354E 354 V E 0.328 Neutral PMS2 P54278 V354F 354 V F 0.24 Neutral PMS2 P54278 V354G 354 V G 0.14 Neutral PMS2 P54278 V354H 354 V H 0.226 Neutral PMS2 P54278 V354I 354 V I 0.014 Neutral PMS2 P54278 V354K 354 V K 0.086 Neutral PMS2 P54278 V354L 354 V L 0.002 Neutral PMS2 P54278 V354M 354 V M 0.116 Neutral PMS2 P54278 V354N 354 V N 0.052 Neutral PMS2 P54278 V354P 354 V P 0.334 Neutral PMS2 P54278 V354Q 354 V Q 0.286 Neutral PMS2 P54278 V354R 354 V R 0.486 Neutral PMS2 P54278 V354S 354 V S 0.018 Neutral PMS2 P54278 V354T 354 V T 0.01 Neutral PMS2 P54278 V354W 354 V W 0.534 Pathogenic PMS2 P54278 V354Y 354 V Y 0.452 Neutral PMS2 P54278 L355A 355 L A 0.26 Neutral PMS2 P54278 L355C 355 L C 0.326 Neutral PMS2 P54278 L355D 355 L D 0.608 Pathogenic PMS2 P54278 L355E 355 L E 0.562 Pathogenic PMS2 P54278 L355F 355 L F 0.772 Pathogenic PMS2 P54278 L355G 355 L G 0.534 Pathogenic PMS2 P54278 L355H 355 L H 0.346 Neutral PMS2 P54278 L355I 355 L I 0.036 Neutral PMS2 P54278 L355K 355 L K 0.442 Neutral PMS2 P54278 L355M 355 L M 0.178 Neutral PMS2 P54278 L355N 355 L N 0.562 Pathogenic PMS2 P54278 L355P 355 L P 0.908 Pathogenic PMS2 P54278 L355Q 355 L Q 0.3 Neutral PMS2 P54278 L355R 355 L R 0.856 Pathogenic PMS2 P54278 L355S 355 L S 0.392 Neutral PMS2 P54278 L355T 355 L T 0.376 Neutral PMS2 P54278 L355V 355 L V 0.006 Neutral PMS2 P54278 L355W 355 L W 0.868 Pathogenic PMS2 P54278 L355Y 355 L Y 0.864 Pathogenic PMS2 P54278 K356A 356 K A 0.216 Neutral PMS2 P54278 K356C 356 K C 0.17 Neutral PMS2 P54278 K356D 356 K D 0.268 Neutral PMS2 P54278 K356E 356 K E 0.306 Neutral PMS2 P54278 K356F 356 K F 0.802 Pathogenic PMS2 P54278 K356G 356 K G 0.328 Neutral PMS2 P54278 K356H 356 K H 0.332 Neutral PMS2 P54278 K356I 356 K I 0.85 Pathogenic PMS2 P54278 K356L 356 K L 0.814 Pathogenic PMS2 P54278 K356M 356 K M 0.61 Pathogenic PMS2 P54278 K356N 356 K N 0.172 Neutral PMS2 P54278 K356P 356 K P 0.796 Pathogenic PMS2 P54278 K356Q 356 K Q 0.188 Neutral PMS2 P54278 K356R 356 K R 0.05 Neutral PMS2 P54278 K356S 356 K S 0.478 Neutral PMS2 P54278 K356T 356 K T 0.398 Neutral PMS2 P54278 K356V 356 K V 0.744 Pathogenic PMS2 P54278 K356W 356 K W 0.976 Pathogenic PMS2 P54278 K356Y 356 K Y 0.92 Pathogenic PMS2 P54278 T357A 357 T A 0 Neutral PMS2 P54278 T357C 357 T C 0.074 Neutral PMS2 P54278 T357D 357 T D 0.07 Neutral PMS2 P54278 T357E 357 T E 0.05 Neutral PMS2 P54278 T357F 357 T F 0.274 Neutral PMS2 P54278 T357G 357 T G 0.092 Neutral PMS2 P54278 T357H 357 T H 0.216 Neutral PMS2 P54278 T357I 357 T I 0.16 Neutral PMS2 P54278 T357K 357 T K 0.012 Neutral PMS2 P54278 T357L 357 T L 0.08 Neutral PMS2 P54278 T357M 357 T M 0.276 Neutral PMS2 P54278 T357N 357 T N 0.004 Neutral PMS2 P54278 T357P 357 T P 0.226 Neutral PMS2 P54278 T357Q 357 T Q 0.024 Neutral PMS2 P54278 T357R 357 T R 0.438 Neutral PMS2 P54278 T357S 357 T S 0 Neutral PMS2 P54278 T357V 357 T V 0.02 Neutral PMS2 P54278 T357W 357 T W 0.708 Pathogenic PMS2 P54278 T357Y 357 T Y 0.51 Pathogenic PMS2 P54278 S358A 358 S A 0.032 Neutral PMS2 P54278 S358C 358 S C 0.242 Neutral PMS2 P54278 S358D 358 S D 0.254 Neutral PMS2 P54278 S358E 358 S E 0.486 Neutral PMS2 P54278 S358F 358 S F 0.77 Pathogenic PMS2 P54278 S358G 358 S G 0.02 Neutral PMS2 P54278 S358H 358 S H 0.622 Pathogenic PMS2 P54278 S358I 358 S I 0.468 Neutral PMS2 P54278 S358K 358 S K 0.488 Neutral PMS2 P54278 S358L 358 S L 0.476 Neutral PMS2 P54278 S358M 358 S M 0.91 Pathogenic PMS2 P54278 S358N 358 S N 0.04 Neutral PMS2 P54278 S358P 358 S P 0.484 Neutral PMS2 P54278 S358Q 358 S Q 0.53 Pathogenic PMS2 P54278 S358R 358 S R 0.704 Pathogenic PMS2 P54278 S358T 358 S T 0.358 Neutral PMS2 P54278 S358V 358 S V 0.736 Pathogenic PMS2 P54278 S358W 358 S W 0.916 Pathogenic PMS2 P54278 S358Y 358 S Y 0.89 Pathogenic PMS2 P54278 L359A 359 L A 0.26 Neutral PMS2 P54278 L359C 359 L C 0.176 Neutral PMS2 P54278 L359D 359 L D 0.608 Pathogenic PMS2 P54278 L359E 359 L E 0.562 Pathogenic PMS2 P54278 L359F 359 L F 0.546 Pathogenic PMS2 P54278 L359G 359 L G 0.534 Pathogenic PMS2 P54278 L359H 359 L H 0.346 Neutral PMS2 P54278 L359I 359 L I 0.042 Neutral PMS2 P54278 L359K 359 L K 0.438 Neutral PMS2 P54278 L359M 359 L M 0.03 Neutral PMS2 P54278 L359N 359 L N 0.562 Pathogenic PMS2 P54278 L359P 359 L P 0.908 Pathogenic PMS2 P54278 L359Q 359 L Q 0.3 Neutral PMS2 P54278 L359R 359 L R 0.856 Pathogenic PMS2 P54278 L359S 359 L S 0.388 Neutral PMS2 P54278 L359T 359 L T 0.222 Neutral PMS2 P54278 L359V 359 L V 0.056 Neutral PMS2 P54278 L359W 359 L W 0.866 Pathogenic PMS2 P54278 L359Y 359 L Y 0.862 Pathogenic PMS2 P54278 S36A 36 S A 0.056 Neutral PMS2 P54278 S36C 36 S C 0.044 Neutral PMS2 P54278 S36D 36 S D 0.13 Neutral PMS2 P54278 S36E 36 S E 0.392 Neutral PMS2 P54278 S36F 36 S F 0.804 Pathogenic PMS2 P54278 S36G 36 S G 0.02 Neutral PMS2 P54278 S36H 36 S H 0.646 Pathogenic PMS2 P54278 S36I 36 S I 0.51 Pathogenic PMS2 P54278 S36K 36 S K 0.406 Neutral PMS2 P54278 S36L 36 S L 0.202 Neutral PMS2 P54278 S36M 36 S M 0.934 Pathogenic PMS2 P54278 S36N 36 S N 0.04 Neutral PMS2 P54278 S36P 36 S P 0.208 Neutral PMS2 P54278 S36Q 36 S Q 0.416 Neutral PMS2 P54278 S36R 36 S R 0.41 Neutral PMS2 P54278 S36T 36 S T 0.072 Neutral PMS2 P54278 S36V 36 S V 0.432 Neutral PMS2 P54278 S36W 36 S W 0.924 Pathogenic PMS2 P54278 S36Y 36 S Y 0.898 Pathogenic PMS2 P54278 I360A 360 I A 0.006 Neutral PMS2 P54278 I360C 360 I C 0.092 Neutral PMS2 P54278 I360D 360 I D 0.174 Neutral PMS2 P54278 I360E 360 I E 0.032 Neutral PMS2 P54278 I360F 360 I F 0.264 Neutral PMS2 P54278 I360G 360 I G 0.234 Neutral PMS2 P54278 I360H 360 I H 0.052 Neutral PMS2 P54278 I360K 360 I K 0.048 Neutral PMS2 P54278 I360L 360 I L 0 Neutral PMS2 P54278 I360M 360 I M 0.02 Neutral PMS2 P54278 I360N 360 I N 0.102 Neutral PMS2 P54278 I360P 360 I P 0.186 Neutral PMS2 P54278 I360Q 360 I Q 0.098 Neutral PMS2 P54278 I360R 360 I R 0.292 Neutral PMS2 P54278 I360S 360 I S 0.144 Neutral PMS2 P54278 I360T 360 I T 0.002 Neutral PMS2 P54278 I360V 360 I V 0 Neutral PMS2 P54278 I360W 360 I W 0.408 Neutral PMS2 P54278 I360Y 360 I Y 0.362 Neutral PMS2 P54278 G361A 361 G A 0.004 Neutral PMS2 P54278 G361C 361 G C 0.178 Neutral PMS2 P54278 G361D 361 G D 0.144 Neutral PMS2 P54278 G361E 361 G E 0.216 Neutral PMS2 P54278 G361F 361 G F 0.54 Pathogenic PMS2 P54278 G361H 361 G H 0.358 Neutral PMS2 P54278 G361I 361 G I 0.452 Neutral PMS2 P54278 G361K 361 G K 0.306 Neutral PMS2 P54278 G361L 361 G L 0.472 Neutral PMS2 P54278 G361M 361 G M 0.478 Neutral PMS2 P54278 G361N 361 G N 0.186 Neutral PMS2 P54278 G361P 361 G P 0.428 Neutral PMS2 P54278 G361Q 361 G Q 0.222 Neutral PMS2 P54278 G361R 361 G R 0.322 Neutral PMS2 P54278 G361S 361 G S 0.02 Neutral PMS2 P54278 G361T 361 G T 0.284 Neutral PMS2 P54278 G361V 361 G V 0.448 Neutral PMS2 P54278 G361W 361 G W 0.546 Pathogenic PMS2 P54278 G361Y 361 G Y 0.542 Pathogenic PMS2 P54278 M362A 362 M A 0.064 Neutral PMS2 P54278 M362C 362 M C 0.078 Neutral PMS2 P54278 M362D 362 M D 0.24 Neutral PMS2 P54278 M362E 362 M E 0.11 Neutral PMS2 P54278 M362F 362 M F 0.426 Neutral PMS2 P54278 M362G 362 M G 0.164 Neutral PMS2 P54278 M362H 362 M H 0.1 Neutral PMS2 P54278 M362I 362 M I 0.012 Neutral PMS2 P54278 M362K 362 M K 0.028 Neutral PMS2 P54278 M362L 362 M L 0.012 Neutral PMS2 P54278 M362N 362 M N 0.278 Neutral PMS2 P54278 M362P 362 M P 0.436 Neutral PMS2 P54278 M362Q 362 M Q 0.05 Neutral PMS2 P54278 M362R 362 M R 0.138 Neutral PMS2 P54278 M362S 362 M S 0.228 Neutral PMS2 P54278 M362T 362 M T 0.008 Neutral PMS2 P54278 M362V 362 M V 0.026 Neutral PMS2 P54278 M362W 362 M W 0.688 Pathogenic PMS2 P54278 M362Y 362 M Y 0.578 Pathogenic PMS2 P54278 F363A 363 F A 0.242 Neutral PMS2 P54278 F363C 363 F C 0.29 Neutral PMS2 P54278 F363D 363 F D 0.594 Pathogenic PMS2 P54278 F363E 363 F E 0.628 Pathogenic PMS2 P54278 F363G 363 F G 0.37 Neutral PMS2 P54278 F363H 363 F H 0.284 Neutral PMS2 P54278 F363I 363 F I 0.382 Neutral PMS2 P54278 F363K 363 F K 0.58 Pathogenic PMS2 P54278 F363L 363 F L 0.274 Neutral PMS2 P54278 F363M 363 F M 0.244 Neutral PMS2 P54278 F363N 363 F N 0.56 Pathogenic PMS2 P54278 F363P 363 F P 0.694 Pathogenic PMS2 P54278 F363Q 363 F Q 0.574 Pathogenic PMS2 P54278 F363R 363 F R 0.578 Pathogenic PMS2 P54278 F363S 363 F S 0.454 Neutral PMS2 P54278 F363T 363 F T 0.462 Neutral PMS2 P54278 F363V 363 F V 0.57 Pathogenic PMS2 P54278 F363W 363 F W 0.528 Pathogenic PMS2 P54278 F363Y 363 F Y 0.036 Neutral PMS2 P54278 D364A 364 D A 0.024 Neutral PMS2 P54278 D364C 364 D C 0.256 Neutral PMS2 P54278 D364E 364 D E 0.018 Neutral PMS2 P54278 D364F 364 D F 0.62 Pathogenic PMS2 P54278 D364G 364 D G 0.02 Neutral PMS2 P54278 D364H 364 D H 0.154 Neutral PMS2 P54278 D364I 364 D I 0.432 Neutral PMS2 P54278 D364K 364 D K 0.02 Neutral PMS2 P54278 D364L 364 D L 0.424 Neutral PMS2 P54278 D364M 364 D M 0.332 Neutral PMS2 P54278 D364N 364 D N 0 Neutral PMS2 P54278 D364P 364 D P 0.444 Neutral PMS2 P54278 D364Q 364 D Q 0.036 Neutral PMS2 P54278 D364R 364 D R 0.26 Neutral PMS2 P54278 D364S 364 D S 0.002 Neutral PMS2 P54278 D364T 364 D T 0.234 Neutral PMS2 P54278 D364V 364 D V 0.396 Neutral PMS2 P54278 D364W 364 D W 0.706 Pathogenic PMS2 P54278 D364Y 364 D Y 0.678 Pathogenic PMS2 P54278 S365A 365 S A 0.014 Neutral PMS2 P54278 S365C 365 S C 0.05 Neutral PMS2 P54278 S365D 365 S D 0.108 Neutral PMS2 P54278 S365E 365 S E 0.222 Neutral PMS2 P54278 S365F 365 S F 0.486 Neutral PMS2 P54278 S365G 365 S G 0.002 Neutral PMS2 P54278 S365H 365 S H 0.344 Neutral PMS2 P54278 S365I 365 S I 0.144 Neutral PMS2 P54278 S365K 365 S K 0.24 Neutral PMS2 P54278 S365L 365 S L 0.064 Neutral PMS2 P54278 S365M 365 S M 0.52 Pathogenic PMS2 P54278 S365N 365 S N 0.002 Neutral PMS2 P54278 S365P 365 S P 0.066 Neutral PMS2 P54278 S365Q 365 S Q 0.248 Neutral PMS2 P54278 S365R 365 S R 0.218 Neutral PMS2 P54278 S365T 365 S T 0.022 Neutral PMS2 P54278 S365V 365 S V 0.382 Neutral PMS2 P54278 S365W 365 S W 0.704 Pathogenic PMS2 P54278 S365Y 365 S Y 0.666 Pathogenic PMS2 P54278 D366A 366 D A 0.1 Neutral PMS2 P54278 D366C 366 D C 0.148 Neutral PMS2 P54278 D366E 366 D E 0.014 Neutral PMS2 P54278 D366F 366 D F 0.296 Neutral PMS2 P54278 D366G 366 D G 0.018 Neutral PMS2 P54278 D366H 366 D H 0.154 Neutral PMS2 P54278 D366I 366 D I 0.11 Neutral PMS2 P54278 D366K 366 D K 0.21 Neutral PMS2 P54278 D366L 366 D L 0.262 Neutral PMS2 P54278 D366M 366 D M 0.19 Neutral PMS2 P54278 D366N 366 D N 0 Neutral PMS2 P54278 D366P 366 D P 0.288 Neutral PMS2 P54278 D366Q 366 D Q 0.172 Neutral PMS2 P54278 D366R 366 D R 0.152 Neutral PMS2 P54278 D366S 366 D S 0.002 Neutral PMS2 P54278 D366T 366 D T 0.012 Neutral PMS2 P54278 D366V 366 D V 0.07 Neutral PMS2 P54278 D366W 366 D W 0.434 Neutral PMS2 P54278 D366Y 366 D Y 0.404 Neutral PMS2 P54278 V367A 367 V A 0 Neutral PMS2 P54278 V367C 367 V C 0.06 Neutral PMS2 P54278 V367D 367 V D 0.136 Neutral PMS2 P54278 V367E 367 V E 0.19 Neutral PMS2 P54278 V367F 367 V F 0.194 Neutral PMS2 P54278 V367G 367 V G 0.184 Neutral PMS2 P54278 V367H 367 V H 0.128 Neutral PMS2 P54278 V367I 367 V I 0.028 Neutral PMS2 P54278 V367K 367 V K 0.19 Neutral PMS2 P54278 V367L 367 V L 0 Neutral PMS2 P54278 V367M 367 V M 0.088 Neutral PMS2 P54278 V367N 367 V N 0.044 Neutral PMS2 P54278 V367P 367 V P 0.042 Neutral PMS2 P54278 V367Q 367 V Q 0.058 Neutral PMS2 P54278 V367R 367 V R 0.26 Neutral PMS2 P54278 V367S 367 V S 0.066 Neutral PMS2 P54278 V367T 367 V T 0.008 Neutral PMS2 P54278 V367W 367 V W 0.374 Neutral PMS2 P54278 V367Y 367 V Y 0.284 Neutral PMS2 P54278 N368A 368 N A 0.012 Neutral PMS2 P54278 N368C 368 N C 0.132 Neutral PMS2 P54278 N368D 368 N D 0.194 Neutral PMS2 P54278 N368E 368 N E 0.166 Neutral PMS2 P54278 N368F 368 N F 0.588 Pathogenic PMS2 P54278 N368G 368 N G 0.224 Neutral PMS2 P54278 N368H 368 N H 0.402 Neutral PMS2 P54278 N368I 368 N I 0.504 Pathogenic PMS2 P54278 N368K 368 N K 0.364 Neutral PMS2 P54278 N368L 368 N L 0.436 Neutral PMS2 P54278 N368M 368 N M 0.368 Neutral PMS2 P54278 N368P 368 N P 0.392 Neutral PMS2 P54278 N368Q 368 N Q 0.192 Neutral PMS2 P54278 N368R 368 N R 0.24 Neutral PMS2 P54278 N368S 368 N S 0.01 Neutral PMS2 P54278 N368T 368 N T 0.014 Neutral PMS2 P54278 N368V 368 N V 0.424 Neutral PMS2 P54278 N368W 368 N W 0.714 Pathogenic PMS2 P54278 N368Y 368 N Y 0.592 Pathogenic PMS2 P54278 K369A 369 K A 0.088 Neutral PMS2 P54278 K369C 369 K C 0.004 Neutral PMS2 P54278 K369D 369 K D 0.102 Neutral PMS2 P54278 K369E 369 K E 0.112 Neutral PMS2 P54278 K369F 369 K F 0.368 Neutral PMS2 P54278 K369G 369 K G 0.186 Neutral PMS2 P54278 K369H 369 K H 0.04 Neutral PMS2 P54278 K369I 369 K I 0.4 Neutral PMS2 P54278 K369L 369 K L 0.164 Neutral PMS2 P54278 K369M 369 K M 0.104 Neutral PMS2 P54278 K369N 369 K N 0.124 Neutral PMS2 P54278 K369P 369 K P 0.392 Neutral PMS2 P54278 K369Q 369 K Q 0.036 Neutral PMS2 P54278 K369R 369 K R 0.014 Neutral PMS2 P54278 K369S 369 K S 0.018 Neutral PMS2 P54278 K369T 369 K T 0.02 Neutral PMS2 P54278 K369V 369 K V 0.306 Neutral PMS2 P54278 K369W 369 K W 0.682 Pathogenic PMS2 P54278 K369Y 369 K Y 0.586 Pathogenic PMS2 P54278 T37A 37 T A 0.034 Neutral PMS2 P54278 T37C 37 T C 0.504 Pathogenic PMS2 P54278 T37D 37 T D 0.122 Neutral PMS2 P54278 T37E 37 T E 0.638 Pathogenic PMS2 P54278 T37F 37 T F 0.754 Pathogenic PMS2 P54278 T37G 37 T G 0.058 Neutral PMS2 P54278 T37H 37 T H 0.598 Pathogenic PMS2 P54278 T37I 37 T I 0.122 Neutral PMS2 P54278 T37K 37 T K 0.11 Neutral PMS2 P54278 T37L 37 T L 0.43 Neutral PMS2 P54278 T37M 37 T M 0.538 Pathogenic PMS2 P54278 T37N 37 T N 0.014 Neutral PMS2 P54278 T37P 37 T P 0.642 Pathogenic PMS2 P54278 T37Q 37 T Q 0.176 Neutral PMS2 P54278 T37R 37 T R 0.844 Pathogenic PMS2 P54278 T37S 37 T S 0.004 Neutral PMS2 P54278 T37V 37 T V 0.052 Neutral PMS2 P54278 T37W 37 T W 0.942 Pathogenic PMS2 P54278 T37Y 37 T Y 0.938 Pathogenic PMS2 P54278 L370A 370 L A 0.124 Neutral PMS2 P54278 L370C 370 L C 0.13 Neutral PMS2 P54278 L370D 370 L D 0.242 Neutral PMS2 P54278 L370E 370 L E 0.226 Neutral PMS2 P54278 L370F 370 L F 0.166 Neutral PMS2 P54278 L370G 370 L G 0.258 Neutral PMS2 P54278 L370H 370 L H 0.122 Neutral PMS2 P54278 L370I 370 L I 0.004 Neutral PMS2 P54278 L370K 370 L K 0.176 Neutral PMS2 P54278 L370M 370 L M 0.094 Neutral PMS2 P54278 L370N 370 L N 0.234 Neutral PMS2 P54278 L370P 370 L P 0.334 Neutral PMS2 P54278 L370Q 370 L Q 0.1 Neutral PMS2 P54278 L370R 370 L R 0.496 Neutral PMS2 P54278 L370S 370 L S 0.19 Neutral PMS2 P54278 L370T 370 L T 0.17 Neutral PMS2 P54278 L370V 370 L V 0.022 Neutral PMS2 P54278 L370W 370 L W 0.526 Pathogenic PMS2 P54278 L370Y 370 L Y 0.386 Neutral PMS2 P54278 N371A 371 N A 0.004 Neutral PMS2 P54278 N371C 371 N C 0.148 Neutral PMS2 P54278 N371D 371 N D 0.008 Neutral PMS2 P54278 N371E 371 N E 0.04 Neutral PMS2 P54278 N371F 371 N F 0.34 Neutral PMS2 P54278 N371G 371 N G 0.1 Neutral PMS2 P54278 N371H 371 N H 0.262 Neutral PMS2 P54278 N371I 371 N I 0.266 Neutral PMS2 P54278 N371K 371 N K 0.082 Neutral PMS2 P54278 N371L 371 N L 0.272 Neutral PMS2 P54278 N371M 371 N M 0.22 Neutral PMS2 P54278 N371P 371 N P 0.338 Neutral PMS2 P54278 N371Q 371 N Q 0.016 Neutral PMS2 P54278 N371R 371 N R 0.136 Neutral PMS2 P54278 N371S 371 N S 0 Neutral PMS2 P54278 N371T 371 N T 0.008 Neutral PMS2 P54278 N371V 371 N V 0.28 Neutral PMS2 P54278 N371W 371 N W 0.446 Neutral PMS2 P54278 N371Y 371 N Y 0.402 Neutral PMS2 P54278 V372A 372 V A 0.074 Neutral PMS2 P54278 V372C 372 V C 0.11 Neutral PMS2 P54278 V372D 372 V D 0.204 Neutral PMS2 P54278 V372E 372 V E 0.334 Neutral PMS2 P54278 V372F 372 V F 0.376 Neutral PMS2 P54278 V372G 372 V G 0.066 Neutral PMS2 P54278 V372H 372 V H 0.23 Neutral PMS2 P54278 V372I 372 V I 0.006 Neutral PMS2 P54278 V372K 372 V K 0.302 Neutral PMS2 P54278 V372L 372 V L 0 Neutral PMS2 P54278 V372M 372 V M 0.024 Neutral PMS2 P54278 V372N 372 V N 0.222 Neutral PMS2 P54278 V372P 372 V P 0.292 Neutral PMS2 P54278 V372Q 372 V Q 0.358 Neutral PMS2 P54278 V372R 372 V R 0.494 Neutral PMS2 P54278 V372S 372 V S 0.148 Neutral PMS2 P54278 V372T 372 V T 0.036 Neutral PMS2 P54278 V372W 372 V W 0.554 Pathogenic PMS2 P54278 V372Y 372 V Y 0.472 Neutral PMS2 P54278 S373A 373 S A 0.144 Neutral PMS2 P54278 S373C 373 S C 0.076 Neutral PMS2 P54278 S373D 373 S D 0.118 Neutral PMS2 P54278 S373E 373 S E 0.33 Neutral PMS2 P54278 S373F 373 S F 0.52 Pathogenic PMS2 P54278 S373G 373 S G 0.12 Neutral PMS2 P54278 S373H 373 S H 0.446 Neutral PMS2 P54278 S373I 373 S I 0.222 Neutral PMS2 P54278 S373K 373 S K 0.374 Neutral PMS2 P54278 S373L 373 S L 0.204 Neutral PMS2 P54278 S373M 373 S M 0.628 Pathogenic PMS2 P54278 S373N 373 S N 0.014 Neutral PMS2 P54278 S373P 373 S P 0.214 Neutral PMS2 P54278 S373Q 373 S Q 0.266 Neutral PMS2 P54278 S373R 373 S R 0.352 Neutral PMS2 P54278 S373T 373 S T 0.264 Neutral PMS2 P54278 S373V 373 S V 0.41 Neutral PMS2 P54278 S373W 373 S W 0.744 Pathogenic PMS2 P54278 S373Y 373 S Y 0.702 Pathogenic PMS2 P54278 Q374A 374 Q A 0.164 Neutral PMS2 P54278 Q374C 374 Q C 0.14 Neutral PMS2 P54278 Q374D 374 Q D 0.134 Neutral PMS2 P54278 Q374E 374 Q E 0.01 Neutral PMS2 P54278 Q374F 374 Q F 0.252 Neutral PMS2 P54278 Q374G 374 Q G 0.168 Neutral PMS2 P54278 Q374H 374 Q H 0.042 Neutral PMS2 P54278 Q374I 374 Q I 0.416 Neutral PMS2 P54278 Q374K 374 Q K 0.142 Neutral PMS2 P54278 Q374L 374 Q L 0.466 Neutral PMS2 P54278 Q374M 374 Q M 0.304 Neutral PMS2 P54278 Q374N 374 Q N 0.024 Neutral PMS2 P54278 Q374P 374 Q P 0.43 Neutral PMS2 P54278 Q374R 374 Q R 0.004 Neutral PMS2 P54278 Q374S 374 Q S 0.064 Neutral PMS2 P54278 Q374T 374 Q T 0.188 Neutral PMS2 P54278 Q374V 374 Q V 0.4 Neutral PMS2 P54278 Q374W 374 Q W 0.646 Pathogenic PMS2 P54278 Q374Y 374 Q Y 0.482 Neutral PMS2 P54278 Q375A 375 Q A 0.138 Neutral PMS2 P54278 Q375C 375 Q C 0.082 Neutral PMS2 P54278 Q375D 375 Q D 0.088 Neutral PMS2 P54278 Q375E 375 Q E 0.084 Neutral PMS2 P54278 Q375F 375 Q F 0.362 Neutral PMS2 P54278 Q375G 375 Q G 0.136 Neutral PMS2 P54278 Q375H 375 Q H 0.262 Neutral PMS2 P54278 Q375I 375 Q I 0.354 Neutral PMS2 P54278 Q375K 375 Q K 0.018 Neutral PMS2 P54278 Q375L 375 Q L 0.116 Neutral PMS2 P54278 Q375M 375 Q M 0.21 Neutral PMS2 P54278 Q375N 375 Q N 0.018 Neutral PMS2 P54278 Q375P 375 Q P 0.294 Neutral PMS2 P54278 Q375R 375 Q R 0.04 Neutral PMS2 P54278 Q375S 375 Q S 0.036 Neutral PMS2 P54278 Q375T 375 Q T 0.002 Neutral PMS2 P54278 Q375V 375 Q V 0.036 Neutral PMS2 P54278 Q375W 375 Q W 0.42 Neutral PMS2 P54278 Q375Y 375 Q Y 0.362 Neutral PMS2 P54278 P376A 376 P A 0.178 Neutral PMS2 P54278 P376C 376 P C 0.152 Neutral PMS2 P54278 P376D 376 P D 0.078 Neutral PMS2 P54278 P376E 376 P E 0.228 Neutral PMS2 P54278 P376F 376 P F 0.29 Neutral PMS2 P54278 P376G 376 P G 0.07 Neutral PMS2 P54278 P376H 376 P H 0.28 Neutral PMS2 P54278 P376I 376 P I 0.112 Neutral PMS2 P54278 P376K 376 P K 0.108 Neutral PMS2 P54278 P376L 376 P L 0.116 Neutral PMS2 P54278 P376M 376 P M 0.102 Neutral PMS2 P54278 P376N 376 P N 0.004 Neutral PMS2 P54278 P376Q 376 P Q 0.168 Neutral PMS2 P54278 P376R 376 P R 0.32 Neutral PMS2 P54278 P376S 376 P S 0.002 Neutral PMS2 P54278 P376T 376 P T 0.086 Neutral PMS2 P54278 P376V 376 P V 0.072 Neutral PMS2 P54278 P376W 376 P W 0.408 Neutral PMS2 P54278 P376Y 376 P Y 0.338 Neutral PMS2 P54278 L377A 377 L A 0.084 Neutral PMS2 P54278 L377C 377 L C 0.078 Neutral PMS2 P54278 L377D 377 L D 0.25 Neutral PMS2 P54278 L377E 377 L E 0.232 Neutral PMS2 P54278 L377F 377 L F 0.416 Neutral PMS2 P54278 L377G 377 L G 0.264 Neutral PMS2 P54278 L377H 377 L H 0.128 Neutral PMS2 P54278 L377I 377 L I 0.006 Neutral PMS2 P54278 L377K 377 L K 0.05 Neutral PMS2 P54278 L377M 377 L M 0.192 Neutral PMS2 P54278 L377N 377 L N 0.242 Neutral PMS2 P54278 L377P 377 L P 0.344 Neutral PMS2 P54278 L377Q 377 L Q 0.032 Neutral PMS2 P54278 L377R 377 L R 0.504 Pathogenic PMS2 P54278 L377S 377 L S 0.198 Neutral PMS2 P54278 L377T 377 L T 0.248 Neutral PMS2 P54278 L377V 377 L V 0.096 Neutral PMS2 P54278 L377W 377 L W 0.536 Pathogenic PMS2 P54278 L377Y 377 L Y 0.498 Neutral PMS2 P54278 L378A 378 L A 0.088 Neutral PMS2 P54278 L378C 378 L C 0.094 Neutral PMS2 P54278 L378D 378 L D 0.098 Neutral PMS2 P54278 L378E 378 L E 0.16 Neutral PMS2 P54278 L378F 378 L F 0.13 Neutral PMS2 P54278 L378G 378 L G 0.192 Neutral PMS2 P54278 L378H 378 L H 0.084 Neutral PMS2 P54278 L378I 378 L I 0.03 Neutral PMS2 P54278 L378K 378 L K 0.124 Neutral PMS2 P54278 L378M 378 L M 0.182 Neutral PMS2 P54278 L378N 378 L N 0.16 Neutral PMS2 P54278 L378P 378 L P 0.1 Neutral PMS2 P54278 L378Q 378 L Q 0.064 Neutral PMS2 P54278 L378R 378 L R 0.356 Neutral PMS2 P54278 L378S 378 L S 0.026 Neutral PMS2 P54278 L378T 378 L T 0.098 Neutral PMS2 P54278 L378V 378 L V 0 Neutral PMS2 P54278 L378W 378 L W 0.398 Neutral PMS2 P54278 L378Y 378 L Y 0.348 Neutral PMS2 P54278 D379A 379 D A 0.028 Neutral PMS2 P54278 D379C 379 D C 0.156 Neutral PMS2 P54278 D379E 379 D E 0.094 Neutral PMS2 P54278 D379F 379 D F 0.388 Neutral PMS2 P54278 D379G 379 D G 0.018 Neutral PMS2 P54278 D379H 379 D H 0.164 Neutral PMS2 P54278 D379I 379 D I 0.27 Neutral PMS2 P54278 D379K 379 D K 0.178 Neutral PMS2 P54278 D379L 379 D L 0.058 Neutral PMS2 P54278 D379M 379 D M 0.198 Neutral PMS2 P54278 D379N 379 D N 0 Neutral PMS2 P54278 D379P 379 D P 0.148 Neutral PMS2 P54278 D379Q 379 D Q 0.174 Neutral PMS2 P54278 D379R 379 D R 0.134 Neutral PMS2 P54278 D379S 379 D S 0.002 Neutral PMS2 P54278 D379T 379 D T 0.16 Neutral PMS2 P54278 D379V 379 D V 0.252 Neutral PMS2 P54278 D379W 379 D W 0.452 Neutral PMS2 P54278 D379Y 379 D Y 0.422 Neutral PMS2 P54278 A38C 38 A C 0.378 Neutral PMS2 P54278 A38D 38 A D 0.912 Pathogenic PMS2 P54278 A38E 38 A E 0.866 Pathogenic PMS2 P54278 A38F 38 A F 0.95 Pathogenic PMS2 P54278 A38G 38 A G 0.742 Pathogenic PMS2 P54278 A38H 38 A H 0.852 Pathogenic PMS2 P54278 A38I 38 A I 0.872 Pathogenic PMS2 P54278 A38K 38 A K 0.918 Pathogenic PMS2 P54278 A38L 38 A L 0.964 Pathogenic PMS2 P54278 A38M 38 A M 0.834 Pathogenic PMS2 P54278 A38N 38 A N 0.842 Pathogenic PMS2 P54278 A38P 38 A P 0.964 Pathogenic PMS2 P54278 A38Q 38 A Q 0.808 Pathogenic PMS2 P54278 A38R 38 A R 0.956 Pathogenic PMS2 P54278 A38S 38 A S 0.416 Neutral PMS2 P54278 A38T 38 A T 0.71 Pathogenic PMS2 P54278 A38V 38 A V 0.398 Neutral PMS2 P54278 A38W 38 A W 0.96 Pathogenic PMS2 P54278 A38Y 38 A Y 0.954 Pathogenic PMS2 P54278 V380A 380 V A 0 Neutral PMS2 P54278 V380C 380 V C 0.058 Neutral PMS2 P54278 V380D 380 V D 0.126 Neutral PMS2 P54278 V380E 380 V E 0.158 Neutral PMS2 P54278 V380F 380 V F 0.172 Neutral PMS2 P54278 V380G 380 V G 0.118 Neutral PMS2 P54278 V380H 380 V H 0.112 Neutral PMS2 P54278 V380I 380 V I 0.008 Neutral PMS2 P54278 V380K 380 V K 0.158 Neutral PMS2 P54278 V380L 380 V L 0.054 Neutral PMS2 P54278 V380M 380 V M 0.012 Neutral PMS2 P54278 V380N 380 V N 0.144 Neutral PMS2 P54278 V380P 380 V P 0.142 Neutral PMS2 P54278 V380Q 380 V Q 0.158 Neutral PMS2 P54278 V380R 380 V R 0.274 Neutral PMS2 P54278 V380S 380 V S 0.064 Neutral PMS2 P54278 V380T 380 V T 0.008 Neutral PMS2 P54278 V380W 380 V W 0.344 Neutral PMS2 P54278 V380Y 380 V Y 0.256 Neutral PMS2 P54278 E381A 381 E A 0.068 Neutral PMS2 P54278 E381C 381 E C 0.064 Neutral PMS2 P54278 E381D 381 E D 0.082 Neutral PMS2 P54278 E381F 381 E F 0.272 Neutral PMS2 P54278 E381G 381 E G 0.024 Neutral PMS2 P54278 E381H 381 E H 0.162 Neutral PMS2 P54278 E381I 381 E I 0.128 Neutral PMS2 P54278 E381K 381 E K 0.068 Neutral PMS2 P54278 E381L 381 E L 0.286 Neutral PMS2 P54278 E381M 381 E M 0.164 Neutral PMS2 P54278 E381N 381 E N 0.04 Neutral PMS2 P54278 E381P 381 E P 0.3 Neutral PMS2 P54278 E381Q 381 E Q 0 Neutral PMS2 P54278 E381R 381 E R 0.03 Neutral PMS2 P54278 E381S 381 E S 0.018 Neutral PMS2 P54278 E381T 381 E T 0.006 Neutral PMS2 P54278 E381V 381 E V 0.142 Neutral PMS2 P54278 E381W 381 E W 0.43 Neutral PMS2 P54278 E381Y 381 E Y 0.338 Neutral PMS2 P54278 G382A 382 G A 0.042 Neutral PMS2 P54278 G382C 382 G C 0.234 Neutral PMS2 P54278 G382D 382 G D 0.16 Neutral PMS2 P54278 G382E 382 G E 0.29 Neutral PMS2 P54278 G382F 382 G F 0.616 Pathogenic PMS2 P54278 G382H 382 G H 0.556 Pathogenic PMS2 P54278 G382I 382 G I 0.534 Pathogenic PMS2 P54278 G382K 382 G K 0.482 Neutral PMS2 P54278 G382L 382 G L 0.364 Neutral PMS2 P54278 G382M 382 G M 0.546 Pathogenic PMS2 P54278 G382N 382 G N 0.326 Neutral PMS2 P54278 G382P 382 G P 0.554 Pathogenic PMS2 P54278 G382Q 382 G Q 0.266 Neutral PMS2 P54278 G382R 382 G R 0.396 Neutral PMS2 P54278 G382S 382 G S 0.022 Neutral PMS2 P54278 G382T 382 G T 0.338 Neutral PMS2 P54278 G382V 382 G V 0.412 Neutral PMS2 P54278 G382W 382 G W 0.614 Pathogenic PMS2 P54278 G382Y 382 G Y 0.522 Pathogenic PMS2 P54278 N383A 383 N A 0.07 Neutral PMS2 P54278 N383C 383 N C 0.158 Neutral PMS2 P54278 N383D 383 N D 0.118 Neutral PMS2 P54278 N383E 383 N E 0.096 Neutral PMS2 P54278 N383F 383 N F 0.34 Neutral PMS2 P54278 N383G 383 N G 0.16 Neutral PMS2 P54278 N383H 383 N H 0.022 Neutral PMS2 P54278 N383I 383 N I 0.266 Neutral PMS2 P54278 N383K 383 N K 0.04 Neutral PMS2 P54278 N383L 383 N L 0.272 Neutral PMS2 P54278 N383M 383 N M 0.22 Neutral PMS2 P54278 N383P 383 N P 0.338 Neutral PMS2 P54278 N383Q 383 N Q 0.038 Neutral PMS2 P54278 N383R 383 N R 0.136 Neutral PMS2 P54278 N383S 383 N S 0 Neutral PMS2 P54278 N383T 383 N T 0.006 Neutral PMS2 P54278 N383V 383 N V 0.12 Neutral PMS2 P54278 N383W 383 N W 0.446 Neutral PMS2 P54278 N383Y 383 N Y 0.414 Neutral PMS2 P54278 L384A 384 L A 0.008 Neutral PMS2 P54278 L384C 384 L C 0.094 Neutral PMS2 P54278 L384D 384 L D 0.156 Neutral PMS2 P54278 L384E 384 L E 0.028 Neutral PMS2 P54278 L384F 384 L F 0.12 Neutral PMS2 P54278 L384G 384 L G 0.186 Neutral PMS2 P54278 L384H 384 L H 0.084 Neutral PMS2 P54278 L384I 384 L I 0.024 Neutral PMS2 P54278 L384K 384 L K 0.178 Neutral PMS2 P54278 L384M 384 L M 0.18 Neutral PMS2 P54278 L384N 384 L N 0.148 Neutral PMS2 P54278 L384P 384 L P 0.216 Neutral PMS2 P54278 L384Q 384 L Q 0.048 Neutral PMS2 P54278 L384R 384 L R 0.232 Neutral PMS2 P54278 L384S 384 L S 0.01 Neutral PMS2 P54278 L384T 384 L T 0.012 Neutral PMS2 P54278 L384V 384 L V 0 Neutral PMS2 P54278 L384W 384 L W 0.334 Neutral PMS2 P54278 L384Y 384 L Y 0.282 Neutral PMS2 P54278 I385A 385 I A 0.072 Neutral PMS2 P54278 I385C 385 I C 0.09 Neutral PMS2 P54278 I385D 385 I D 0.166 Neutral PMS2 P54278 I385E 385 I E 0.076 Neutral PMS2 P54278 I385F 385 I F 0.07 Neutral PMS2 P54278 I385G 385 I G 0.108 Neutral PMS2 P54278 I385H 385 I H 0.08 Neutral PMS2 P54278 I385K 385 I K 0.042 Neutral PMS2 P54278 I385L 385 I L 0.002 Neutral PMS2 P54278 I385M 385 I M 0.018 Neutral PMS2 P54278 I385N 385 I N 0.176 Neutral PMS2 P54278 I385P 385 I P 0.174 Neutral PMS2 P54278 I385Q 385 I Q 0.174 Neutral PMS2 P54278 I385R 385 I R 0.244 Neutral PMS2 P54278 I385S 385 I S 0.16 Neutral PMS2 P54278 I385T 385 I T 0.192 Neutral PMS2 P54278 I385V 385 I V 0 Neutral PMS2 P54278 I385W 385 I W 0.344 Neutral PMS2 P54278 I385Y 385 I Y 0.298 Neutral PMS2 P54278 K386A 386 K A 0.096 Neutral PMS2 P54278 K386C 386 K C 0 Neutral PMS2 P54278 K386D 386 K D 0.066 Neutral PMS2 P54278 K386E 386 K E 0.01 Neutral PMS2 P54278 K386F 386 K F 0.242 Neutral PMS2 P54278 K386G 386 K G 0.13 Neutral PMS2 P54278 K386H 386 K H 0.048 Neutral PMS2 P54278 K386I 386 K I 0.202 Neutral PMS2 P54278 K386L 386 K L 0.058 Neutral PMS2 P54278 K386M 386 K M 0.112 Neutral PMS2 P54278 K386N 386 K N 0.014 Neutral PMS2 P54278 K386P 386 K P 0.014 Neutral PMS2 P54278 K386Q 386 K Q 0.048 Neutral PMS2 P54278 K386R 386 K R 0.004 Neutral PMS2 P54278 K386S 386 K S 0.014 Neutral PMS2 P54278 K386T 386 K T 0.028 Neutral PMS2 P54278 K386V 386 K V 0.194 Neutral PMS2 P54278 K386W 386 K W 0.414 Neutral PMS2 P54278 K386Y 386 K Y 0.346 Neutral PMS2 P54278 M387A 387 M A 0.07 Neutral PMS2 P54278 M387C 387 M C 0.042 Neutral PMS2 P54278 M387D 387 M D 0.154 Neutral PMS2 P54278 M387E 387 M E 0.034 Neutral PMS2 P54278 M387F 387 M F 0.26 Neutral PMS2 P54278 M387G 387 M G 0.11 Neutral PMS2 P54278 M387H 387 M H 0.058 Neutral PMS2 P54278 M387I 387 M I 0.004 Neutral PMS2 P54278 M387K 387 M K 0.016 Neutral PMS2 P54278 M387L 387 M L 0.004 Neutral PMS2 P54278 M387N 387 M N 0.18 Neutral PMS2 P54278 M387P 387 M P 0.128 Neutral PMS2 P54278 M387Q 387 M Q 0.006 Neutral PMS2 P54278 M387R 387 M R 0.044 Neutral PMS2 P54278 M387S 387 M S 0.064 Neutral PMS2 P54278 M387T 387 M T 0.008 Neutral PMS2 P54278 M387V 387 M V 0.016 Neutral PMS2 P54278 M387W 387 M W 0.422 Neutral PMS2 P54278 M387Y 387 M Y 0.386 Neutral PMS2 P54278 H388A 388 H A 0.076 Neutral PMS2 P54278 H388C 388 H C 0.048 Neutral PMS2 P54278 H388D 388 H D 0.006 Neutral PMS2 P54278 H388E 388 H E 0.002 Neutral PMS2 P54278 H388F 388 H F 0.246 Neutral PMS2 P54278 H388G 388 H G 0.11 Neutral PMS2 P54278 H388I 388 H I 0.274 Neutral PMS2 P54278 H388K 388 H K 0.144 Neutral PMS2 P54278 H388L 388 H L 0.02 Neutral PMS2 P54278 H388M 388 H M 0.108 Neutral PMS2 P54278 H388N 388 H N 0.002 Neutral PMS2 P54278 H388P 388 H P 0.028 Neutral PMS2 P54278 H388Q 388 H Q 0.094 Neutral PMS2 P54278 H388R 388 H R 0 Neutral PMS2 P54278 H388S 388 H S 0.014 Neutral PMS2 P54278 H388T 388 H T 0.186 Neutral PMS2 P54278 H388V 388 H V 0.016 Neutral PMS2 P54278 H388W 388 H W 0.398 Neutral PMS2 P54278 H388Y 388 H Y 0.306 Neutral PMS2 P54278 A389C 389 A C 0.182 Neutral PMS2 P54278 A389D 389 A D 0.316 Neutral PMS2 P54278 A389E 389 A E 0.286 Neutral PMS2 P54278 A389F 389 A F 0.468 Neutral PMS2 P54278 A389G 389 A G 0.154 Neutral PMS2 P54278 A389H 389 A H 0.304 Neutral PMS2 P54278 A389I 389 A I 0.406 Neutral PMS2 P54278 A389K 389 A K 0.354 Neutral PMS2 P54278 A389L 389 A L 0.322 Neutral PMS2 P54278 A389M 389 A M 0.29 Neutral PMS2 P54278 A389N 389 A N 0.274 Neutral PMS2 P54278 A389P 389 A P 0.036 Neutral PMS2 P54278 A389Q 389 A Q 0.248 Neutral PMS2 P54278 A389R 389 A R 0.298 Neutral PMS2 P54278 A389S 389 A S 0.004 Neutral PMS2 P54278 A389T 389 A T 0.012 Neutral PMS2 P54278 A389V 389 A V 0.04 Neutral PMS2 P54278 A389W 389 A W 0.484 Neutral PMS2 P54278 A389Y 389 A Y 0.482 Neutral PMS2 P54278 V39A 39 V A 0.07 Neutral PMS2 P54278 V39C 39 V C 0.13 Neutral PMS2 P54278 V39D 39 V D 0.868 Pathogenic PMS2 P54278 V39E 39 V E 0.238 Neutral PMS2 P54278 V39F 39 V F 0.862 Pathogenic PMS2 P54278 V39G 39 V G 0.904 Pathogenic PMS2 P54278 V39H 39 V H 0.802 Pathogenic PMS2 P54278 V39I 39 V I 0.176 Neutral PMS2 P54278 V39K 39 V K 0.966 Pathogenic PMS2 P54278 V39L 39 V L 0.32 Neutral PMS2 P54278 V39M 39 V M 0.218 Neutral PMS2 P54278 V39N 39 V N 0.934 Pathogenic PMS2 P54278 V39P 39 V P 0.966 Pathogenic PMS2 P54278 V39Q 39 V Q 0.602 Pathogenic PMS2 P54278 V39R 39 V R 0.958 Pathogenic PMS2 P54278 V39S 39 V S 0.154 Neutral PMS2 P54278 V39T 39 V T 0.096 Neutral PMS2 P54278 V39W 39 V W 0.896 Pathogenic PMS2 P54278 V39Y 39 V Y 0.92 Pathogenic PMS2 P54278 A390C 390 A C 0.212 Neutral PMS2 P54278 A390D 390 A D 0.266 Neutral PMS2 P54278 A390E 390 A E 0.288 Neutral PMS2 P54278 A390F 390 A F 0.34 Neutral PMS2 P54278 A390G 390 A G 0.022 Neutral PMS2 P54278 A390H 390 A H 0.304 Neutral PMS2 P54278 A390I 390 A I 0.334 Neutral PMS2 P54278 A390K 390 A K 0.354 Neutral PMS2 P54278 A390L 390 A L 0.32 Neutral PMS2 P54278 A390M 390 A M 0.29 Neutral PMS2 P54278 A390N 390 A N 0.314 Neutral PMS2 P54278 A390P 390 A P 0.138 Neutral PMS2 P54278 A390Q 390 A Q 0.278 Neutral PMS2 P54278 A390R 390 A R 0.298 Neutral PMS2 P54278 A390S 390 A S 0.024 Neutral PMS2 P54278 A390T 390 A T 0.012 Neutral PMS2 P54278 A390V 390 A V 0.04 Neutral PMS2 P54278 A390W 390 A W 0.504 Pathogenic PMS2 P54278 A390Y 390 A Y 0.5 Pathogenic PMS2 P54278 D391A 391 D A 0.014 Neutral PMS2 P54278 D391C 391 D C 0.17 Neutral PMS2 P54278 D391E 391 D E 0.016 Neutral PMS2 P54278 D391F 391 D F 0.37 Neutral PMS2 P54278 D391G 391 D G 0.036 Neutral PMS2 P54278 D391H 391 D H 0.106 Neutral PMS2 P54278 D391I 391 D I 0.262 Neutral PMS2 P54278 D391K 391 D K 0.176 Neutral PMS2 P54278 D391L 391 D L 0.262 Neutral PMS2 P54278 D391M 391 D M 0.19 Neutral PMS2 P54278 D391N 391 D N 0.02 Neutral PMS2 P54278 D391P 391 D P 0.036 Neutral PMS2 P54278 D391Q 391 D Q 0.112 Neutral PMS2 P54278 D391R 391 D R 0.152 Neutral PMS2 P54278 D391S 391 D S 0.002 Neutral PMS2 P54278 D391T 391 D T 0.032 Neutral PMS2 P54278 D391V 391 D V 0.242 Neutral PMS2 P54278 D391W 391 D W 0.434 Neutral PMS2 P54278 D391Y 391 D Y 0.404 Neutral PMS2 P54278 L392A 392 L A 0.008 Neutral PMS2 P54278 L392C 392 L C 0.094 Neutral PMS2 P54278 L392D 392 L D 0.038 Neutral PMS2 P54278 L392E 392 L E 0.106 Neutral PMS2 P54278 L392F 392 L F 0.242 Neutral PMS2 P54278 L392G 392 L G 0.08 Neutral PMS2 P54278 L392H 392 L H 0.006 Neutral PMS2 P54278 L392I 392 L I 0.004 Neutral PMS2 P54278 L392K 392 L K 0.116 Neutral PMS2 P54278 L392M 392 L M 0.01 Neutral PMS2 P54278 L392N 392 L N 0.148 Neutral PMS2 P54278 L392P 392 L P 0.224 Neutral PMS2 P54278 L392Q 392 L Q 0.064 Neutral PMS2 P54278 L392R 392 L R 0.236 Neutral PMS2 P54278 L392S 392 L S 0.014 Neutral PMS2 P54278 L392T 392 L T 0.012 Neutral PMS2 P54278 L392V 392 L V 0 Neutral PMS2 P54278 L392W 392 L W 0.334 Neutral PMS2 P54278 L392Y 392 L Y 0.284 Neutral PMS2 P54278 E393A 393 E A 0.212 Neutral PMS2 P54278 E393C 393 E C 0.068 Neutral PMS2 P54278 E393D 393 E D 0 Neutral PMS2 P54278 E393F 393 E F 0.296 Neutral PMS2 P54278 E393G 393 E G 0.002 Neutral PMS2 P54278 E393H 393 E H 0.096 Neutral PMS2 P54278 E393I 393 E I 0.352 Neutral PMS2 P54278 E393K 393 E K 0.068 Neutral PMS2 P54278 E393L 393 E L 0.308 Neutral PMS2 P54278 E393M 393 E M 0.176 Neutral PMS2 P54278 E393N 393 E N 0.002 Neutral PMS2 P54278 E393P 393 E P 0.322 Neutral PMS2 P54278 E393Q 393 E Q 0.012 Neutral PMS2 P54278 E393R 393 E R 0.048 Neutral PMS2 P54278 E393S 393 E S 0.014 Neutral PMS2 P54278 E393T 393 E T 0.008 Neutral PMS2 P54278 E393V 393 E V 0.25 Neutral PMS2 P54278 E393W 393 E W 0.508 Pathogenic PMS2 P54278 E393Y 393 E Y 0.472 Neutral PMS2 P54278 K394A 394 K A 0.056 Neutral PMS2 P54278 K394C 394 K C 0.028 Neutral PMS2 P54278 K394D 394 K D 0.05 Neutral PMS2 P54278 K394E 394 K E 0.01 Neutral PMS2 P54278 K394F 394 K F 0.212 Neutral PMS2 P54278 K394G 394 K G 0.044 Neutral PMS2 P54278 K394H 394 K H 0 Neutral PMS2 P54278 K394I 394 K I 0.19 Neutral PMS2 P54278 K394L 394 K L 0.052 Neutral PMS2 P54278 K394M 394 K M 0.106 Neutral PMS2 P54278 K394N 394 K N 0.05 Neutral PMS2 P54278 K394P 394 K P 0.03 Neutral PMS2 P54278 K394Q 394 K Q 0.006 Neutral PMS2 P54278 K394R 394 K R 0.002 Neutral PMS2 P54278 K394S 394 K S 0.014 Neutral PMS2 P54278 K394T 394 K T 0.012 Neutral PMS2 P54278 K394V 394 K V 0.12 Neutral PMS2 P54278 K394W 394 K W 0.396 Neutral PMS2 P54278 K394Y 394 K Y 0.324 Neutral PMS2 P54278 P395A 395 P A 0.036 Neutral PMS2 P54278 P395C 395 P C 0.158 Neutral PMS2 P54278 P395D 395 P D 0.052 Neutral PMS2 P54278 P395E 395 P E 0.2 Neutral PMS2 P54278 P395F 395 P F 0.326 Neutral PMS2 P54278 P395G 395 P G 0.092 Neutral PMS2 P54278 P395H 395 P H 0.31 Neutral PMS2 P54278 P395I 395 P I 0.12 Neutral PMS2 P54278 P395K 395 P K 0.062 Neutral PMS2 P54278 P395L 395 P L 0.048 Neutral PMS2 P54278 P395M 395 P M 0.218 Neutral PMS2 P54278 P395N 395 P N 0.008 Neutral PMS2 P54278 P395Q 395 P Q 0.11 Neutral PMS2 P54278 P395R 395 P R 0.23 Neutral PMS2 P54278 P395S 395 P S 0.022 Neutral PMS2 P54278 P395T 395 P T 0.016 Neutral PMS2 P54278 P395V 395 P V 0.05 Neutral PMS2 P54278 P395W 395 P W 0.438 Neutral PMS2 P54278 P395Y 395 P Y 0.364 Neutral PMS2 P54278 M396A 396 M A 0.122 Neutral PMS2 P54278 M396C 396 M C 0.048 Neutral PMS2 P54278 M396D 396 M D 0.154 Neutral PMS2 P54278 M396E 396 M E 0.008 Neutral PMS2 P54278 M396F 396 M F 0.034 Neutral PMS2 P54278 M396G 396 M G 0.136 Neutral PMS2 P54278 M396H 396 M H 0.026 Neutral PMS2 P54278 M396I 396 M I 0.004 Neutral PMS2 P54278 M396K 396 M K 0.06 Neutral PMS2 P54278 M396L 396 M L 0.004 Neutral PMS2 P54278 M396N 396 M N 0.072 Neutral PMS2 P54278 M396P 396 M P 0.032 Neutral PMS2 P54278 M396Q 396 M Q 0.002 Neutral PMS2 P54278 M396R 396 M R 0.042 Neutral PMS2 P54278 M396S 396 M S 0.008 Neutral PMS2 P54278 M396T 396 M T 0.142 Neutral PMS2 P54278 M396V 396 M V 0.016 Neutral PMS2 P54278 M396W 396 M W 0.332 Neutral PMS2 P54278 M396Y 396 M Y 0.348 Neutral PMS2 P54278 V397A 397 V A 0 Neutral PMS2 P54278 V397C 397 V C 0.058 Neutral PMS2 P54278 V397D 397 V D 0.122 Neutral PMS2 P54278 V397E 397 V E 0.098 Neutral PMS2 P54278 V397F 397 V F 0.172 Neutral PMS2 P54278 V397G 397 V G 0.038 Neutral PMS2 P54278 V397H 397 V H 0.068 Neutral PMS2 P54278 V397I 397 V I 0.028 Neutral PMS2 P54278 V397K 397 V K 0.074 Neutral PMS2 P54278 V397L 397 V L 0 Neutral PMS2 P54278 V397M 397 V M 0.034 Neutral PMS2 P54278 V397N 397 V N 0.138 Neutral PMS2 P54278 V397P 397 V P 0.04 Neutral PMS2 P54278 V397Q 397 V Q 0.158 Neutral PMS2 P54278 V397R 397 V R 0.274 Neutral PMS2 P54278 V397S 397 V S 0.01 Neutral PMS2 P54278 V397T 397 V T 0.008 Neutral PMS2 P54278 V397W 397 V W 0.344 Neutral PMS2 P54278 V397Y 397 V Y 0.256 Neutral PMS2 P54278 E398A 398 E A 0.066 Neutral PMS2 P54278 E398C 398 E C 0.068 Neutral PMS2 P54278 E398D 398 E D 0 Neutral PMS2 P54278 E398F 398 E F 0.272 Neutral PMS2 P54278 E398G 398 E G 0 Neutral PMS2 P54278 E398H 398 E H 0.162 Neutral PMS2 P54278 E398I 398 E I 0.158 Neutral PMS2 P54278 E398K 398 E K 0.068 Neutral PMS2 P54278 E398L 398 E L 0.042 Neutral PMS2 P54278 E398M 398 E M 0.166 Neutral PMS2 P54278 E398N 398 E N 0.04 Neutral PMS2 P54278 E398P 398 E P 0.042 Neutral PMS2 P54278 E398Q 398 E Q 0 Neutral PMS2 P54278 E398R 398 E R 0.046 Neutral PMS2 P54278 E398S 398 E S 0.014 Neutral PMS2 P54278 E398T 398 E T 0.006 Neutral PMS2 P54278 E398V 398 E V 0.232 Neutral PMS2 P54278 E398W 398 E W 0.43 Neutral PMS2 P54278 E398Y 398 E Y 0.338 Neutral PMS2 P54278 K399A 399 K A 0.056 Neutral PMS2 P54278 K399C 399 K C 0.028 Neutral PMS2 P54278 K399D 399 K D 0.01 Neutral PMS2 P54278 K399E 399 K E 0.004 Neutral PMS2 P54278 K399F 399 K F 0.23 Neutral PMS2 P54278 K399G 399 K G 0.132 Neutral PMS2 P54278 K399H 399 K H 0.018 Neutral PMS2 P54278 K399I 399 K I 0.04 Neutral PMS2 P54278 K399L 399 K L 0.104 Neutral PMS2 P54278 K399M 399 K M 0.028 Neutral PMS2 P54278 K399N 399 K N 0.046 Neutral PMS2 P54278 K399P 399 K P 0.214 Neutral PMS2 P54278 K399Q 399 K Q 0.01 Neutral PMS2 P54278 K399R 399 K R 0.012 Neutral PMS2 P54278 K399S 399 K S 0.014 Neutral PMS2 P54278 K399T 399 K T 0.018 Neutral PMS2 P54278 K399V 399 K V 0.022 Neutral PMS2 P54278 K399W 399 K W 0.396 Neutral PMS2 P54278 K399Y 399 K Y 0.326 Neutral PMS2 P54278 A4C 4 A C 0.182 Neutral PMS2 P54278 A4D 4 A D 0.316 Neutral PMS2 P54278 A4E 4 A E 0.274 Neutral PMS2 P54278 A4F 4 A F 0.292 Neutral PMS2 P54278 A4G 4 A G 0.154 Neutral PMS2 P54278 A4H 4 A H 0.304 Neutral PMS2 P54278 A4I 4 A I 0.334 Neutral PMS2 P54278 A4K 4 A K 0.252 Neutral PMS2 P54278 A4L 4 A L 0.314 Neutral PMS2 P54278 A4M 4 A M 0.256 Neutral PMS2 P54278 A4N 4 A N 0.274 Neutral PMS2 P54278 A4P 4 A P 0.138 Neutral PMS2 P54278 A4Q 4 A Q 0.278 Neutral PMS2 P54278 A4R 4 A R 0.326 Neutral PMS2 P54278 A4S 4 A S 0.008 Neutral PMS2 P54278 A4T 4 A T 0.012 Neutral PMS2 P54278 A4V 4 A V 0.074 Neutral PMS2 P54278 A4W 4 A W 0.504 Pathogenic PMS2 P54278 A4Y 4 A Y 0.5 Pathogenic PMS2 P54278 K40A 40 K A 0.1 Neutral PMS2 P54278 K40C 40 K C 0.44 Neutral PMS2 P54278 K40D 40 K D 0.07 Neutral PMS2 P54278 K40E 40 K E 0.074 Neutral PMS2 P54278 K40F 40 K F 0.946 Pathogenic PMS2 P54278 K40G 40 K G 0.302 Neutral PMS2 P54278 K40H 40 K H 0.724 Pathogenic PMS2 P54278 K40I 40 K I 0.984 Pathogenic PMS2 P54278 K40L 40 K L 0.68 Pathogenic PMS2 P54278 K40M 40 K M 0.892 Pathogenic PMS2 P54278 K40N 40 K N 0.096 Neutral PMS2 P54278 K40P 40 K P 0.908 Pathogenic PMS2 P54278 K40Q 40 K Q 0.272 Neutral PMS2 P54278 K40R 40 K R 0.168 Neutral PMS2 P54278 K40S 40 K S 0.126 Neutral PMS2 P54278 K40T 40 K T 0.118 Neutral PMS2 P54278 K40V 40 K V 0.516 Pathogenic PMS2 P54278 K40W 40 K W 0.988 Pathogenic PMS2 P54278 K40Y 40 K Y 0.978 Pathogenic PMS2 P54278 Q400A 400 Q A 0.08 Neutral PMS2 P54278 Q400C 400 Q C 0.048 Neutral PMS2 P54278 Q400D 400 Q D 0.088 Neutral PMS2 P54278 Q400E 400 Q E 0.028 Neutral PMS2 P54278 Q400F 400 Q F 0.26 Neutral PMS2 P54278 Q400G 400 Q G 0.03 Neutral PMS2 P54278 Q400H 400 Q H 0.14 Neutral PMS2 P54278 Q400I 400 Q I 0.278 Neutral PMS2 P54278 Q400K 400 Q K 0.022 Neutral PMS2 P54278 Q400L 400 Q L 0.112 Neutral PMS2 P54278 Q400M 400 Q M 0.21 Neutral PMS2 P54278 Q400N 400 Q N 0.064 Neutral PMS2 P54278 Q400P 400 Q P 0.22 Neutral PMS2 P54278 Q400R 400 Q R 0.002 Neutral PMS2 P54278 Q400S 400 Q S 0.054 Neutral PMS2 P54278 Q400T 400 Q T 0.002 Neutral PMS2 P54278 Q400V 400 Q V 0.01 Neutral PMS2 P54278 Q400W 400 Q W 0.42 Neutral PMS2 P54278 Q400Y 400 Q Y 0.452 Neutral PMS2 P54278 D401A 401 D A 0.014 Neutral PMS2 P54278 D401C 401 D C 0.124 Neutral PMS2 P54278 D401E 401 D E 0.014 Neutral PMS2 P54278 D401F 401 D F 0.37 Neutral PMS2 P54278 D401G 401 D G 0.018 Neutral PMS2 P54278 D401H 401 D H 0.106 Neutral PMS2 P54278 D401I 401 D I 0.262 Neutral PMS2 P54278 D401K 401 D K 0.022 Neutral PMS2 P54278 D401L 401 D L 0.026 Neutral PMS2 P54278 D401M 401 D M 0.19 Neutral PMS2 P54278 D401N 401 D N 0 Neutral PMS2 P54278 D401P 401 D P 0.042 Neutral PMS2 P54278 D401Q 401 D Q 0.014 Neutral PMS2 P54278 D401R 401 D R 0.166 Neutral PMS2 P54278 D401S 401 D S 0.074 Neutral PMS2 P54278 D401T 401 D T 0.032 Neutral PMS2 P54278 D401V 401 D V 0.188 Neutral PMS2 P54278 D401W 401 D W 0.434 Neutral PMS2 P54278 D401Y 401 D Y 0.404 Neutral PMS2 P54278 Q402A 402 Q A 0.138 Neutral PMS2 P54278 Q402C 402 Q C 0.082 Neutral PMS2 P54278 Q402D 402 Q D 0 Neutral PMS2 P54278 Q402E 402 Q E 0.12 Neutral PMS2 P54278 Q402F 402 Q F 0.26 Neutral PMS2 P54278 Q402G 402 Q G 0.054 Neutral PMS2 P54278 Q402H 402 Q H 0.034 Neutral PMS2 P54278 Q402I 402 Q I 0.354 Neutral PMS2 P54278 Q402K 402 Q K 0.108 Neutral PMS2 P54278 Q402L 402 Q L 0.12 Neutral PMS2 P54278 Q402M 402 Q M 0.104 Neutral PMS2 P54278 Q402N 402 Q N 0.018 Neutral PMS2 P54278 Q402P 402 Q P 0.22 Neutral PMS2 P54278 Q402R 402 Q R 0.002 Neutral PMS2 P54278 Q402S 402 Q S 0.034 Neutral PMS2 P54278 Q402T 402 Q T 0.002 Neutral PMS2 P54278 Q402V 402 Q V 0.092 Neutral PMS2 P54278 Q402W 402 Q W 0.42 Neutral PMS2 P54278 Q402Y 402 Q Y 0.362 Neutral PMS2 P54278 S403A 403 S A 0.01 Neutral PMS2 P54278 S403C 403 S C 0.022 Neutral PMS2 P54278 S403D 403 S D 0.024 Neutral PMS2 P54278 S403E 403 S E 0.122 Neutral PMS2 P54278 S403F 403 S F 0.266 Neutral PMS2 P54278 S403G 403 S G 0.036 Neutral PMS2 P54278 S403H 403 S H 0.176 Neutral PMS2 P54278 S403I 403 S I 0.196 Neutral PMS2 P54278 S403K 403 S K 0.14 Neutral PMS2 P54278 S403L 403 S L 0.062 Neutral PMS2 P54278 S403M 403 S M 0.28 Neutral PMS2 P54278 S403N 403 S N 0.012 Neutral PMS2 P54278 S403P 403 S P 0.056 Neutral PMS2 P54278 S403Q 403 S Q 0.172 Neutral PMS2 P54278 S403R 403 S R 0.17 Neutral PMS2 P54278 S403T 403 S T 0.046 Neutral PMS2 P54278 S403V 403 S V 0.134 Neutral PMS2 P54278 S403W 403 S W 0.49 Neutral PMS2 P54278 S403Y 403 S Y 0.448 Neutral PMS2 P54278 P404A 404 P A 0.032 Neutral PMS2 P54278 P404C 404 P C 0.148 Neutral PMS2 P54278 P404D 404 P D 0.028 Neutral PMS2 P54278 P404E 404 P E 0.052 Neutral PMS2 P54278 P404F 404 P F 0.272 Neutral PMS2 P54278 P404G 404 P G 0.024 Neutral PMS2 P54278 P404H 404 P H 0.266 Neutral PMS2 P54278 P404I 404 P I 0.1 Neutral PMS2 P54278 P404K 404 P K 0.05 Neutral PMS2 P54278 P404L 404 P L 0.042 Neutral PMS2 P54278 P404M 404 P M 0.22 Neutral PMS2 P54278 P404N 404 P N 0.068 Neutral PMS2 P54278 P404Q 404 P Q 0.052 Neutral PMS2 P54278 P404R 404 P R 0.306 Neutral PMS2 P54278 P404S 404 P S 0.004 Neutral PMS2 P54278 P404T 404 P T 0.014 Neutral PMS2 P54278 P404V 404 P V 0.07 Neutral PMS2 P54278 P404W 404 P W 0.39 Neutral PMS2 P54278 P404Y 404 P Y 0.32 Neutral PMS2 P54278 S405A 405 S A 0.01 Neutral PMS2 P54278 S405C 405 S C 0.032 Neutral PMS2 P54278 S405D 405 S D 0.024 Neutral PMS2 P54278 S405E 405 S E 0.148 Neutral PMS2 P54278 S405F 405 S F 0.256 Neutral PMS2 P54278 S405G 405 S G 0.066 Neutral PMS2 P54278 S405H 405 S H 0.238 Neutral PMS2 P54278 S405I 405 S I 0.124 Neutral PMS2 P54278 S405K 405 S K 0.146 Neutral PMS2 P54278 S405L 405 S L 0.032 Neutral PMS2 P54278 S405M 405 S M 0.332 Neutral PMS2 P54278 S405N 405 S N 0.018 Neutral PMS2 P54278 S405P 405 S P 0.062 Neutral PMS2 P54278 S405Q 405 S Q 0.132 Neutral PMS2 P54278 S405R 405 S R 0.152 Neutral PMS2 P54278 S405T 405 S T 0.02 Neutral PMS2 P54278 S405V 405 S V 0.034 Neutral PMS2 P54278 S405W 405 S W 0.49 Neutral PMS2 P54278 S405Y 405 S Y 0.414 Neutral PMS2 P54278 L406A 406 L A 0.022 Neutral PMS2 P54278 L406C 406 L C 0.094 Neutral PMS2 P54278 L406D 406 L D 0.092 Neutral PMS2 P54278 L406E 406 L E 0.032 Neutral PMS2 P54278 L406F 406 L F 0.126 Neutral PMS2 P54278 L406G 406 L G 0.184 Neutral PMS2 P54278 L406H 406 L H 0.084 Neutral PMS2 P54278 L406I 406 L I 0.024 Neutral PMS2 P54278 L406K 406 L K 0.084 Neutral PMS2 P54278 L406M 406 L M 0.132 Neutral PMS2 P54278 L406N 406 L N 0.04 Neutral PMS2 P54278 L406P 406 L P 0.086 Neutral PMS2 P54278 L406Q 406 L Q 0.004 Neutral PMS2 P54278 L406R 406 L R 0.236 Neutral PMS2 P54278 L406S 406 L S 0.01 Neutral PMS2 P54278 L406T 406 L T 0.096 Neutral PMS2 P54278 L406V 406 L V 0 Neutral PMS2 P54278 L406W 406 L W 0.334 Neutral PMS2 P54278 L406Y 406 L Y 0.284 Neutral PMS2 P54278 R407A 407 R A 0.126 Neutral PMS2 P54278 R407C 407 R C 0.14 Neutral PMS2 P54278 R407D 407 R D 0.024 Neutral PMS2 P54278 R407E 407 R E 0.02 Neutral PMS2 P54278 R407F 407 R F 0.27 Neutral PMS2 P54278 R407G 407 R G 0.002 Neutral PMS2 P54278 R407H 407 R H 0.12 Neutral PMS2 P54278 R407I 407 R I 0.304 Neutral PMS2 P54278 R407K 407 R K 0.008 Neutral PMS2 P54278 R407L 407 R L 0.012 Neutral PMS2 P54278 R407M 407 R M 0.15 Neutral PMS2 P54278 R407N 407 R N 0.008 Neutral PMS2 P54278 R407P 407 R P 0.262 Neutral PMS2 P54278 R407Q 407 R Q 0.116 Neutral PMS2 P54278 R407S 407 R S 0.016 Neutral PMS2 P54278 R407T 407 R T 0.026 Neutral PMS2 P54278 R407V 407 R V 0.242 Neutral PMS2 P54278 R407W 407 R W 0.384 Neutral PMS2 P54278 R407Y 407 R Y 0.284 Neutral PMS2 P54278 T408A 408 T A 0.014 Neutral PMS2 P54278 T408C 408 T C 0.064 Neutral PMS2 P54278 T408D 408 T D 0.038 Neutral PMS2 P54278 T408E 408 T E 0.032 Neutral PMS2 P54278 T408F 408 T F 0.214 Neutral PMS2 P54278 T408G 408 T G 0.002 Neutral PMS2 P54278 T408H 408 T H 0.084 Neutral PMS2 P54278 T408I 408 T I 0.066 Neutral PMS2 P54278 T408K 408 T K 0.002 Neutral PMS2 P54278 T408L 408 T L 0.074 Neutral PMS2 P54278 T408M 408 T M 0.098 Neutral PMS2 P54278 T408N 408 T N 0.052 Neutral PMS2 P54278 T408P 408 T P 0.008 Neutral PMS2 P54278 T408Q 408 T Q 0 Neutral PMS2 P54278 T408R 408 T R 0.156 Neutral PMS2 P54278 T408S 408 T S 0.032 Neutral PMS2 P54278 T408V 408 T V 0.212 Neutral PMS2 P54278 T408W 408 T W 0.466 Neutral PMS2 P54278 T408Y 408 T Y 0.424 Neutral PMS2 P54278 G409A 409 G A 0.002 Neutral PMS2 P54278 G409C 409 G C 0.14 Neutral PMS2 P54278 G409D 409 G D 0.244 Neutral PMS2 P54278 G409E 409 G E 0.166 Neutral PMS2 P54278 G409F 409 G F 0.478 Neutral PMS2 P54278 G409H 409 G H 0.442 Neutral PMS2 P54278 G409I 409 G I 0.408 Neutral PMS2 P54278 G409K 409 G K 0.312 Neutral PMS2 P54278 G409L 409 G L 0.412 Neutral PMS2 P54278 G409M 409 G M 0.422 Neutral PMS2 P54278 G409N 409 G N 0.172 Neutral PMS2 P54278 G409P 409 G P 0.402 Neutral PMS2 P54278 G409Q 409 G Q 0.18 Neutral PMS2 P54278 G409R 409 G R 0.306 Neutral PMS2 P54278 G409S 409 G S 0.018 Neutral PMS2 P54278 G409T 409 G T 0.26 Neutral PMS2 P54278 G409V 409 G V 0.394 Neutral PMS2 P54278 G409W 409 G W 0.498 Neutral PMS2 P54278 G409Y 409 G Y 0.5 Pathogenic PMS2 P54278 E41A 41 E A 0.358 Neutral PMS2 P54278 E41C 41 E C 0.382 Neutral PMS2 P54278 E41D 41 E D 0.416 Neutral PMS2 P54278 E41F 41 E F 0.944 Pathogenic PMS2 P54278 E41G 41 E G 0.334 Neutral PMS2 P54278 E41H 41 E H 0.684 Pathogenic PMS2 P54278 E41I 41 E I 0.972 Pathogenic PMS2 P54278 E41K 41 E K 0.286 Neutral PMS2 P54278 E41L 41 E L 0.956 Pathogenic PMS2 P54278 E41M 41 E M 0.886 Pathogenic PMS2 P54278 E41N 41 E N 0.752 Pathogenic PMS2 P54278 E41P 41 E P 0.924 Pathogenic PMS2 P54278 E41Q 41 E Q 0.244 Neutral PMS2 P54278 E41R 41 E R 0.372 Neutral PMS2 P54278 E41S 41 E S 0.854 Pathogenic PMS2 P54278 E41T 41 E T 0.336 Neutral PMS2 P54278 E41V 41 E V 0.908 Pathogenic PMS2 P54278 E41W 41 E W 0.974 Pathogenic PMS2 P54278 E41Y 41 E Y 0.95 Pathogenic PMS2 P54278 E410A 410 E A 0.066 Neutral PMS2 P54278 E410C 410 E C 0.068 Neutral PMS2 P54278 E410D 410 E D 0 Neutral PMS2 P54278 E410F 410 E F 0.282 Neutral PMS2 P54278 E410G 410 E G 0.002 Neutral PMS2 P54278 E410H 410 E H 0.164 Neutral PMS2 P54278 E410I 410 E I 0.294 Neutral PMS2 P54278 E410K 410 E K 0.002 Neutral PMS2 P54278 E410L 410 E L 0.3 Neutral PMS2 P54278 E410M 410 E M 0.172 Neutral PMS2 P54278 E410N 410 E N 0.006 Neutral PMS2 P54278 E410P 410 E P 0.29 Neutral PMS2 P54278 E410Q 410 E Q 0.012 Neutral PMS2 P54278 E410R 410 E R 0.032 Neutral PMS2 P54278 E410S 410 E S 0.058 Neutral PMS2 P54278 E410T 410 E T 0.022 Neutral PMS2 P54278 E410V 410 E V 0.242 Neutral PMS2 P54278 E410W 410 E W 0.448 Neutral PMS2 P54278 E410Y 410 E Y 0.358 Neutral PMS2 P54278 E411A 411 E A 0.118 Neutral PMS2 P54278 E411C 411 E C 0.09 Neutral PMS2 P54278 E411D 411 E D 0 Neutral PMS2 P54278 E411F 411 E F 0.272 Neutral PMS2 P54278 E411G 411 E G 0 Neutral PMS2 P54278 E411H 411 E H 0.162 Neutral PMS2 P54278 E411I 411 E I 0.284 Neutral PMS2 P54278 E411K 411 E K 0.068 Neutral PMS2 P54278 E411L 411 E L 0.286 Neutral PMS2 P54278 E411M 411 E M 0.164 Neutral PMS2 P54278 E411N 411 E N 0.04 Neutral PMS2 P54278 E411P 411 E P 0.282 Neutral PMS2 P54278 E411Q 411 E Q 0.018 Neutral PMS2 P54278 E411R 411 E R 0.016 Neutral PMS2 P54278 E411S 411 E S 0.014 Neutral PMS2 P54278 E411T 411 E T 0.02 Neutral PMS2 P54278 E411V 411 E V 0.232 Neutral PMS2 P54278 E411W 411 E W 0.43 Neutral PMS2 P54278 E411Y 411 E Y 0.338 Neutral PMS2 P54278 K412A 412 K A 0.096 Neutral PMS2 P54278 K412C 412 K C 0.028 Neutral PMS2 P54278 K412D 412 K D 0.01 Neutral PMS2 P54278 K412E 412 K E 0.052 Neutral PMS2 P54278 K412F 412 K F 0.248 Neutral PMS2 P54278 K412G 412 K G 0.134 Neutral PMS2 P54278 K412H 412 K H 0.01 Neutral PMS2 P54278 K412I 412 K I 0.068 Neutral PMS2 P54278 K412L 412 K L 0.166 Neutral PMS2 P54278 K412M 412 K M 0.112 Neutral PMS2 P54278 K412N 412 K N 0.014 Neutral PMS2 P54278 K412P 412 K P 0.016 Neutral PMS2 P54278 K412Q 412 K Q 0.09 Neutral PMS2 P54278 K412R 412 K R 0.002 Neutral PMS2 P54278 K412S 412 K S 0.024 Neutral PMS2 P54278 K412T 412 K T 0.09 Neutral PMS2 P54278 K412V 412 K V 0.192 Neutral PMS2 P54278 K412W 412 K W 0.46 Neutral PMS2 P54278 K412Y 412 K Y 0.374 Neutral PMS2 P54278 K413A 413 K A 0.096 Neutral PMS2 P54278 K413C 413 K C 0.028 Neutral PMS2 P54278 K413D 413 K D 0.066 Neutral PMS2 P54278 K413E 413 K E 0.004 Neutral PMS2 P54278 K413F 413 K F 0.24 Neutral PMS2 P54278 K413G 413 K G 0.116 Neutral PMS2 P54278 K413H 413 K H 0.048 Neutral PMS2 P54278 K413I 413 K I 0.042 Neutral PMS2 P54278 K413L 413 K L 0.108 Neutral PMS2 P54278 K413M 413 K M 0.112 Neutral PMS2 P54278 K413N 413 K N 0.082 Neutral PMS2 P54278 K413P 413 K P 0.242 Neutral PMS2 P54278 K413Q 413 K Q 0.006 Neutral PMS2 P54278 K413R 413 K R 0.006 Neutral PMS2 P54278 K413S 413 K S 0.014 Neutral PMS2 P54278 K413T 413 K T 0.028 Neutral PMS2 P54278 K413V 413 K V 0.186 Neutral PMS2 P54278 K413W 413 K W 0.414 Neutral PMS2 P54278 K413Y 413 K Y 0.344 Neutral PMS2 P54278 D414A 414 D A 0.016 Neutral PMS2 P54278 D414C 414 D C 0.148 Neutral PMS2 P54278 D414E 414 D E 0.094 Neutral PMS2 P54278 D414F 414 D F 0.37 Neutral PMS2 P54278 D414G 414 D G 0.082 Neutral PMS2 P54278 D414H 414 D H 0.09 Neutral PMS2 P54278 D414I 414 D I 0.11 Neutral PMS2 P54278 D414K 414 D K 0.21 Neutral PMS2 P54278 D414L 414 D L 0.262 Neutral PMS2 P54278 D414M 414 D M 0.19 Neutral PMS2 P54278 D414N 414 D N 0.02 Neutral PMS2 P54278 D414P 414 D P 0.036 Neutral PMS2 P54278 D414Q 414 D Q 0.172 Neutral PMS2 P54278 D414R 414 D R 0.15 Neutral PMS2 P54278 D414S 414 D S 0.002 Neutral PMS2 P54278 D414T 414 D T 0.014 Neutral PMS2 P54278 D414V 414 D V 0.06 Neutral PMS2 P54278 D414W 414 D W 0.434 Neutral PMS2 P54278 D414Y 414 D Y 0.404 Neutral PMS2 P54278 V415A 415 V A 0 Neutral PMS2 P54278 V415C 415 V C 0.058 Neutral PMS2 P54278 V415D 415 V D 0.034 Neutral PMS2 P54278 V415E 415 V E 0.042 Neutral PMS2 P54278 V415F 415 V F 0.142 Neutral PMS2 P54278 V415G 415 V G 0.054 Neutral PMS2 P54278 V415H 415 V H 0.068 Neutral PMS2 P54278 V415I 415 V I 0.028 Neutral PMS2 P54278 V415K 415 V K 0.158 Neutral PMS2 P54278 V415L 415 V L 0.002 Neutral PMS2 P54278 V415M 415 V M 0.014 Neutral PMS2 P54278 V415N 415 V N 0.138 Neutral PMS2 P54278 V415P 415 V P 0.088 Neutral PMS2 P54278 V415Q 415 V Q 0.06 Neutral PMS2 P54278 V415R 415 V R 0.21 Neutral PMS2 P54278 V415S 415 V S 0.09 Neutral PMS2 P54278 V415T 415 V T 0.058 Neutral PMS2 P54278 V415W 415 V W 0.344 Neutral PMS2 P54278 V415Y 415 V Y 0.256 Neutral PMS2 P54278 S416A 416 S A 0.01 Neutral PMS2 P54278 S416C 416 S C 0.022 Neutral PMS2 P54278 S416D 416 S D 0.028 Neutral PMS2 P54278 S416E 416 S E 0.132 Neutral PMS2 P54278 S416F 416 S F 0.298 Neutral PMS2 P54278 S416G 416 S G 0.064 Neutral PMS2 P54278 S416H 416 S H 0.21 Neutral PMS2 P54278 S416I 416 S I 0.172 Neutral PMS2 P54278 S416K 416 S K 0.18 Neutral PMS2 P54278 S416L 416 S L 0.032 Neutral PMS2 P54278 S416M 416 S M 0.374 Neutral PMS2 P54278 S416N 416 S N 0.02 Neutral PMS2 P54278 S416P 416 S P 0.116 Neutral PMS2 P54278 S416Q 416 S Q 0.172 Neutral PMS2 P54278 S416R 416 S R 0.168 Neutral PMS2 P54278 S416T 416 S T 0.018 Neutral PMS2 P54278 S416V 416 S V 0.256 Neutral PMS2 P54278 S416W 416 S W 0.524 Pathogenic PMS2 P54278 S416Y 416 S Y 0.48 Neutral PMS2 P54278 I417A 417 I A 0.06 Neutral PMS2 P54278 I417C 417 I C 0.09 Neutral PMS2 P54278 I417D 417 I D 0.03 Neutral PMS2 P54278 I417E 417 I E 0.136 Neutral PMS2 P54278 I417F 417 I F 0.216 Neutral PMS2 P54278 I417G 417 I G 0.208 Neutral PMS2 P54278 I417H 417 I H 0.048 Neutral PMS2 P54278 I417K 417 I K 0.12 Neutral PMS2 P54278 I417L 417 I L 0 Neutral PMS2 P54278 I417M 417 I M 0.114 Neutral PMS2 P54278 I417N 417 I N 0.18 Neutral PMS2 P54278 I417P 417 I P 0.072 Neutral PMS2 P54278 I417Q 417 I Q 0.202 Neutral PMS2 P54278 I417R 417 I R 0.252 Neutral PMS2 P54278 I417S 417 I S 0.162 Neutral PMS2 P54278 I417T 417 I T 0.192 Neutral PMS2 P54278 I417V 417 I V 0 Neutral PMS2 P54278 I417W 417 I W 0.354 Neutral PMS2 P54278 I417Y 417 I Y 0.31 Neutral PMS2 P54278 S418A 418 S A 0.01 Neutral PMS2 P54278 S418C 418 S C 0.008 Neutral PMS2 P54278 S418D 418 S D 0.048 Neutral PMS2 P54278 S418E 418 S E 0.136 Neutral PMS2 P54278 S418F 418 S F 0.308 Neutral PMS2 P54278 S418G 418 S G 0.064 Neutral PMS2 P54278 S418H 418 S H 0.216 Neutral PMS2 P54278 S418I 418 S I 0.142 Neutral PMS2 P54278 S418K 418 S K 0.188 Neutral PMS2 P54278 S418L 418 S L 0.086 Neutral PMS2 P54278 S418M 418 S M 0.384 Neutral PMS2 P54278 S418N 418 S N 0.016 Neutral PMS2 P54278 S418P 418 S P 0.122 Neutral PMS2 P54278 S418Q 418 S Q 0.18 Neutral PMS2 P54278 S418R 418 S R 0.146 Neutral PMS2 P54278 S418T 418 S T 0.046 Neutral PMS2 P54278 S418V 418 S V 0.036 Neutral PMS2 P54278 S418W 418 S W 0.532 Pathogenic PMS2 P54278 S418Y 418 S Y 0.488 Neutral PMS2 P54278 R419A 419 R A 0.08 Neutral PMS2 P54278 R419C 419 R C 0.154 Neutral PMS2 P54278 R419D 419 R D 0.182 Neutral PMS2 P54278 R419E 419 R E 0.022 Neutral PMS2 P54278 R419F 419 R F 0.294 Neutral PMS2 P54278 R419G 419 R G 0.038 Neutral PMS2 P54278 R419H 419 R H 0.122 Neutral PMS2 P54278 R419I 419 R I 0.208 Neutral PMS2 P54278 R419K 419 R K 0.004 Neutral PMS2 P54278 R419L 419 R L 0.07 Neutral PMS2 P54278 R419M 419 R M 0.174 Neutral PMS2 P54278 R419N 419 R N 0.178 Neutral PMS2 P54278 R419P 419 R P 0.036 Neutral PMS2 P54278 R419Q 419 R Q 0.116 Neutral PMS2 P54278 R419S 419 R S 0.016 Neutral PMS2 P54278 R419T 419 R T 0.068 Neutral PMS2 P54278 R419V 419 R V 0.19 Neutral PMS2 P54278 R419W 419 R W 0.444 Neutral PMS2 P54278 R419Y 419 R Y 0.308 Neutral PMS2 P54278 L42A 42 L A 0.712 Pathogenic PMS2 P54278 L42C 42 L C 0.822 Pathogenic PMS2 P54278 L42D 42 L D 0.91 Pathogenic PMS2 P54278 L42E 42 L E 0.894 Pathogenic PMS2 P54278 L42F 42 L F 0.876 Pathogenic PMS2 P54278 L42G 42 L G 0.862 Pathogenic PMS2 P54278 L42H 42 L H 0.908 Pathogenic PMS2 P54278 L42I 42 L I 0.542 Pathogenic PMS2 P54278 L42K 42 L K 0.716 Pathogenic PMS2 P54278 L42M 42 L M 0.606 Pathogenic PMS2 P54278 L42N 42 L N 0.82 Pathogenic PMS2 P54278 L42P 42 L P 0.994 Pathogenic PMS2 P54278 L42Q 42 L Q 0.774 Pathogenic PMS2 P54278 L42R 42 L R 0.984 Pathogenic PMS2 P54278 L42S 42 L S 0.694 Pathogenic PMS2 P54278 L42T 42 L T 0.618 Pathogenic PMS2 P54278 L42V 42 L V 0.332 Neutral PMS2 P54278 L42W 42 L W 0.878 Pathogenic PMS2 P54278 L42Y 42 L Y 0.886 Pathogenic PMS2 P54278 L420A 420 L A 0.032 Neutral PMS2 P54278 L420C 420 L C 0.138 Neutral PMS2 P54278 L420D 420 L D 0.254 Neutral PMS2 P54278 L420E 420 L E 0.044 Neutral PMS2 P54278 L420F 420 L F 0.378 Neutral PMS2 P54278 L420G 420 L G 0.254 Neutral PMS2 P54278 L420H 420 L H 0.13 Neutral PMS2 P54278 L420I 420 L I 0.124 Neutral PMS2 P54278 L420K 420 L K 0.186 Neutral PMS2 P54278 L420M 420 L M 0.196 Neutral PMS2 P54278 L420N 420 L N 0.23 Neutral PMS2 P54278 L420P 420 L P 0.178 Neutral PMS2 P54278 L420Q 420 L Q 0.084 Neutral PMS2 P54278 L420R 420 L R 0.368 Neutral PMS2 P54278 L420S 420 L S 0.106 Neutral PMS2 P54278 L420T 420 L T 0.182 Neutral PMS2 P54278 L420V 420 L V 0.188 Neutral PMS2 P54278 L420W 420 L W 0.54 Pathogenic PMS2 P54278 L420Y 420 L Y 0.502 Pathogenic PMS2 P54278 R421A 421 R A 0.08 Neutral PMS2 P54278 R421C 421 R C 0.236 Neutral PMS2 P54278 R421D 421 R D 0.094 Neutral PMS2 P54278 R421E 421 R E 0.23 Neutral PMS2 P54278 R421F 421 R F 0.074 Neutral PMS2 P54278 R421G 421 R G 0.104 Neutral PMS2 P54278 R421H 421 R H 0.182 Neutral PMS2 P54278 R421I 421 R I 0.266 Neutral PMS2 P54278 R421K 421 R K 0.018 Neutral PMS2 P54278 R421L 421 R L 0.424 Neutral PMS2 P54278 R421M 421 R M 0.25 Neutral PMS2 P54278 R421N 421 R N 0.262 Neutral PMS2 P54278 R421P 421 R P 0.408 Neutral PMS2 P54278 R421Q 421 R Q 0.314 Neutral PMS2 P54278 R421S 421 R S 0.024 Neutral PMS2 P54278 R421T 421 R T 0.21 Neutral PMS2 P54278 R421V 421 R V 0.374 Neutral PMS2 P54278 R421W 421 R W 0.614 Pathogenic PMS2 P54278 R421Y 421 R Y 0.44 Neutral PMS2 P54278 E422A 422 E A 0.084 Neutral PMS2 P54278 E422C 422 E C 0.124 Neutral PMS2 P54278 E422D 422 E D 0.136 Neutral PMS2 P54278 E422F 422 E F 0.43 Neutral PMS2 P54278 E422G 422 E G 0.114 Neutral PMS2 P54278 E422H 422 E H 0.176 Neutral PMS2 P54278 E422I 422 E I 0.45 Neutral PMS2 P54278 E422K 422 E K 0.046 Neutral PMS2 P54278 E422L 422 E L 0.452 Neutral PMS2 P54278 E422M 422 E M 0.288 Neutral PMS2 P54278 E422N 422 E N 0.092 Neutral PMS2 P54278 E422P 422 E P 0.436 Neutral PMS2 P54278 E422Q 422 E Q 0.03 Neutral PMS2 P54278 E422R 422 E R 0.072 Neutral PMS2 P54278 E422S 422 E S 0.022 Neutral PMS2 P54278 E422T 422 E T 0.222 Neutral PMS2 P54278 E422V 422 E V 0.1 Neutral PMS2 P54278 E422W 422 E W 0.702 Pathogenic PMS2 P54278 E422Y 422 E Y 0.586 Pathogenic PMS2 P54278 A423C 423 A C 0.196 Neutral PMS2 P54278 A423D 423 A D 0.356 Neutral PMS2 P54278 A423E 423 A E 0.326 Neutral PMS2 P54278 A423F 423 A F 0.446 Neutral PMS2 P54278 A423G 423 A G 0.126 Neutral PMS2 P54278 A423H 423 A H 0.334 Neutral PMS2 P54278 A423I 423 A I 0.436 Neutral PMS2 P54278 A423K 423 A K 0.386 Neutral PMS2 P54278 A423L 423 A L 0.338 Neutral PMS2 P54278 A423M 423 A M 0.32 Neutral PMS2 P54278 A423N 423 A N 0.338 Neutral PMS2 P54278 A423P 423 A P 0.084 Neutral PMS2 P54278 A423Q 423 A Q 0.332 Neutral PMS2 P54278 A423R 423 A R 0.4 Neutral PMS2 P54278 A423S 423 A S 0.006 Neutral PMS2 P54278 A423T 423 A T 0.016 Neutral PMS2 P54278 A423V 423 A V 0.142 Neutral PMS2 P54278 A423W 423 A W 0.52 Pathogenic PMS2 P54278 A423Y 423 A Y 0.534 Pathogenic PMS2 P54278 F424A 424 F A 0.076 Neutral PMS2 P54278 F424C 424 F C 0.122 Neutral PMS2 P54278 F424D 424 F D 0.224 Neutral PMS2 P54278 F424E 424 F E 0.244 Neutral PMS2 P54278 F424G 424 F G 0.18 Neutral PMS2 P54278 F424H 424 F H 0.106 Neutral PMS2 P54278 F424I 424 F I 0.094 Neutral PMS2 P54278 F424K 424 F K 0.072 Neutral PMS2 P54278 F424L 424 F L 0.018 Neutral PMS2 P54278 F424M 424 F M 0.084 Neutral PMS2 P54278 F424N 424 F N 0.236 Neutral PMS2 P54278 F424P 424 F P 0.224 Neutral PMS2 P54278 F424Q 424 F Q 0.238 Neutral PMS2 P54278 F424R 424 F R 0.112 Neutral PMS2 P54278 F424S 424 F S 0.02 Neutral PMS2 P54278 F424T 424 F T 0.222 Neutral PMS2 P54278 F424V 424 F V 0.22 Neutral PMS2 P54278 F424W 424 F W 0.442 Neutral PMS2 P54278 F424Y 424 F Y 0.224 Neutral PMS2 P54278 S425A 425 S A 0.094 Neutral PMS2 P54278 S425C 425 S C 0.078 Neutral PMS2 P54278 S425D 425 S D 0.054 Neutral PMS2 P54278 S425E 425 S E 0.334 Neutral PMS2 P54278 S425F 425 S F 0.498 Neutral PMS2 P54278 S425G 425 S G 0.078 Neutral PMS2 P54278 S425H 425 S H 0.448 Neutral PMS2 P54278 S425I 425 S I 0.174 Neutral PMS2 P54278 S425K 425 S K 0.266 Neutral PMS2 P54278 S425L 425 S L 0.178 Neutral PMS2 P54278 S425M 425 S M 0.632 Pathogenic PMS2 P54278 S425N 425 S N 0.066 Neutral PMS2 P54278 S425P 425 S P 0.138 Neutral PMS2 P54278 S425Q 425 S Q 0.258 Neutral PMS2 P54278 S425R 425 S R 0.356 Neutral PMS2 P54278 S425T 425 S T 0.268 Neutral PMS2 P54278 S425V 425 S V 0.452 Neutral PMS2 P54278 S425W 425 S W 0.748 Pathogenic PMS2 P54278 S425Y 425 S Y 0.706 Pathogenic PMS2 P54278 L426A 426 L A 0.074 Neutral PMS2 P54278 L426C 426 L C 0.13 Neutral PMS2 P54278 L426D 426 L D 0.242 Neutral PMS2 P54278 L426E 426 L E 0.056 Neutral PMS2 P54278 L426F 426 L F 0.366 Neutral PMS2 P54278 L426G 426 L G 0.166 Neutral PMS2 P54278 L426H 426 L H 0.064 Neutral PMS2 P54278 L426I 426 L I 0.112 Neutral PMS2 P54278 L426K 426 L K 0.242 Neutral PMS2 P54278 L426M 426 L M 0.186 Neutral PMS2 P54278 L426N 426 L N 0.216 Neutral PMS2 P54278 L426P 426 L P 0.334 Neutral PMS2 P54278 L426Q 426 L Q 0.1 Neutral PMS2 P54278 L426R 426 L R 0.496 Neutral PMS2 P54278 L426S 426 L S 0.02 Neutral PMS2 P54278 L426T 426 L T 0.238 Neutral PMS2 P54278 L426V 426 L V 0.096 Neutral PMS2 P54278 L426W 426 L W 0.526 Pathogenic PMS2 P54278 L426Y 426 L Y 0.488 Neutral PMS2 P54278 R427A 427 R A 0.086 Neutral PMS2 P54278 R427C 427 R C 0.14 Neutral PMS2 P54278 R427D 427 R D 0.074 Neutral PMS2 P54278 R427E 427 R E 0.162 Neutral PMS2 P54278 R427F 427 R F 0.28 Neutral PMS2 P54278 R427G 427 R G 0.038 Neutral PMS2 P54278 R427H 427 R H 0.004 Neutral PMS2 P54278 R427I 427 R I 0.304 Neutral PMS2 P54278 R427K 427 R K 0.168 Neutral PMS2 P54278 R427L 427 R L 0.062 Neutral PMS2 P54278 R427M 427 R M 0.164 Neutral PMS2 P54278 R427N 427 R N 0.176 Neutral PMS2 P54278 R427P 427 R P 0.262 Neutral PMS2 P54278 R427Q 427 R Q 0.116 Neutral PMS2 P54278 R427S 427 R S 0.016 Neutral PMS2 P54278 R427T 427 R T 0.164 Neutral PMS2 P54278 R427V 427 R V 0.178 Neutral PMS2 P54278 R427W 427 R W 0.384 Neutral PMS2 P54278 R427Y 427 R Y 0.284 Neutral PMS2 P54278 H428A 428 H A 0.108 Neutral PMS2 P54278 H428C 428 H C 0.042 Neutral PMS2 P54278 H428D 428 H D 0.032 Neutral PMS2 P54278 H428E 428 H E 0.028 Neutral PMS2 P54278 H428F 428 H F 0.204 Neutral PMS2 P54278 H428G 428 H G 0.11 Neutral PMS2 P54278 H428I 428 H I 0.258 Neutral PMS2 P54278 H428K 428 H K 0.144 Neutral PMS2 P54278 H428L 428 H L 0.016 Neutral PMS2 P54278 H428M 428 H M 0.108 Neutral PMS2 P54278 H428N 428 H N 0.058 Neutral PMS2 P54278 H428P 428 H P 0.026 Neutral PMS2 P54278 H428Q 428 H Q 0.006 Neutral PMS2 P54278 H428R 428 H R 0.016 Neutral PMS2 P54278 H428S 428 H S 0.014 Neutral PMS2 P54278 H428T 428 H T 0.008 Neutral PMS2 P54278 H428V 428 H V 0.132 Neutral PMS2 P54278 H428W 428 H W 0.404 Neutral PMS2 P54278 H428Y 428 H Y 0.148 Neutral PMS2 P54278 T429A 429 T A 0 Neutral PMS2 P54278 T429C 429 T C 0.03 Neutral PMS2 P54278 T429D 429 T D 0.02 Neutral PMS2 P54278 T429E 429 T E 0.04 Neutral PMS2 P54278 T429F 429 T F 0.214 Neutral PMS2 P54278 T429G 429 T G 0.036 Neutral PMS2 P54278 T429H 429 T H 0.056 Neutral PMS2 P54278 T429I 429 T I 0.076 Neutral PMS2 P54278 T429K 429 T K 0.002 Neutral PMS2 P54278 T429L 429 T L 0.074 Neutral PMS2 P54278 T429M 429 T M 0.024 Neutral PMS2 P54278 T429N 429 T N 0 Neutral PMS2 P54278 T429P 429 T P 0.008 Neutral PMS2 P54278 T429Q 429 T Q 0 Neutral PMS2 P54278 T429R 429 T R 0.14 Neutral PMS2 P54278 T429S 429 T S 0 Neutral PMS2 P54278 T429V 429 T V 0.212 Neutral PMS2 P54278 T429W 429 T W 0.466 Neutral PMS2 P54278 T429Y 429 T Y 0.424 Neutral PMS2 P54278 V43A 43 V A 0.04 Neutral PMS2 P54278 V43C 43 V C 0.394 Neutral PMS2 P54278 V43D 43 V D 0.06 Neutral PMS2 P54278 V43E 43 V E 0.12 Neutral PMS2 P54278 V43F 43 V F 0.764 Pathogenic PMS2 P54278 V43G 43 V G 0.472 Neutral PMS2 P54278 V43H 43 V H 0.198 Neutral PMS2 P54278 V43I 43 V I 0.048 Neutral PMS2 P54278 V43K 43 V K 0.186 Neutral PMS2 P54278 V43L 43 V L 0.046 Neutral PMS2 P54278 V43M 43 V M 0.262 Neutral PMS2 P54278 V43N 43 V N 0.116 Neutral PMS2 P54278 V43P 43 V P 0.86 Pathogenic PMS2 P54278 V43Q 43 V Q 0.132 Neutral PMS2 P54278 V43R 43 V R 0.544 Pathogenic PMS2 P54278 V43S 43 V S 0.038 Neutral PMS2 P54278 V43T 43 V T 0.026 Neutral PMS2 P54278 V43W 43 V W 0.84 Pathogenic PMS2 P54278 V43Y 43 V Y 0.83 Pathogenic PMS2 P54278 T430A 430 T A 0 Neutral PMS2 P54278 T430C 430 T C 0.064 Neutral PMS2 P54278 T430D 430 T D 0.046 Neutral PMS2 P54278 T430E 430 T E 0.024 Neutral PMS2 P54278 T430F 430 T F 0.186 Neutral PMS2 P54278 T430G 430 T G 0.036 Neutral PMS2 P54278 T430H 430 T H 0.084 Neutral PMS2 P54278 T430I 430 T I 0.096 Neutral PMS2 P54278 T430K 430 T K 0.002 Neutral PMS2 P54278 T430L 430 T L 0.008 Neutral PMS2 P54278 T430M 430 T M 0.048 Neutral PMS2 P54278 T430N 430 T N 0.02 Neutral PMS2 P54278 T430P 430 T P 0.01 Neutral PMS2 P54278 T430Q 430 T Q 0.052 Neutral PMS2 P54278 T430R 430 T R 0.174 Neutral PMS2 P54278 T430S 430 T S 0 Neutral PMS2 P54278 T430V 430 T V 0.016 Neutral PMS2 P54278 T430W 430 T W 0.466 Neutral PMS2 P54278 T430Y 430 T Y 0.424 Neutral PMS2 P54278 E431A 431 E A 0.066 Neutral PMS2 P54278 E431C 431 E C 0.068 Neutral PMS2 P54278 E431D 431 E D 0.004 Neutral PMS2 P54278 E431F 431 E F 0.168 Neutral PMS2 P54278 E431G 431 E G 0 Neutral PMS2 P54278 E431H 431 E H 0.106 Neutral PMS2 P54278 E431I 431 E I 0.332 Neutral PMS2 P54278 E431K 431 E K 0.026 Neutral PMS2 P54278 E431L 431 E L 0.144 Neutral PMS2 P54278 E431M 431 E M 0.04 Neutral PMS2 P54278 E431N 431 E N 0.036 Neutral PMS2 P54278 E431P 431 E P 0.288 Neutral PMS2 P54278 E431Q 431 E Q 0.056 Neutral PMS2 P54278 E431R 431 E R 0.046 Neutral PMS2 P54278 E431S 431 E S 0.014 Neutral PMS2 P54278 E431T 431 E T 0.008 Neutral PMS2 P54278 E431V 431 E V 0.24 Neutral PMS2 P54278 E431W 431 E W 0.448 Neutral PMS2 P54278 E431Y 431 E Y 0.356 Neutral PMS2 P54278 N432A 432 N A 0.004 Neutral PMS2 P54278 N432C 432 N C 0.092 Neutral PMS2 P54278 N432D 432 N D 0.068 Neutral PMS2 P54278 N432E 432 N E 0.016 Neutral PMS2 P54278 N432F 432 N F 0.418 Neutral PMS2 P54278 N432G 432 N G 0.02 Neutral PMS2 P54278 N432H 432 N H 0.132 Neutral PMS2 P54278 N432I 432 N I 0.234 Neutral PMS2 P54278 N432K 432 N K 0.038 Neutral PMS2 P54278 N432L 432 N L 0.314 Neutral PMS2 P54278 N432M 432 N M 0.22 Neutral PMS2 P54278 N432P 432 N P 0.228 Neutral PMS2 P54278 N432Q 432 N Q 0.014 Neutral PMS2 P54278 N432R 432 N R 0.136 Neutral PMS2 P54278 N432S 432 N S 0 Neutral PMS2 P54278 N432T 432 N T 0.006 Neutral PMS2 P54278 N432V 432 N V 0.262 Neutral PMS2 P54278 N432W 432 N W 0.446 Neutral PMS2 P54278 N432Y 432 N Y 0.432 Neutral PMS2 P54278 K433A 433 K A 0.054 Neutral PMS2 P54278 K433C 433 K C 0.028 Neutral PMS2 P54278 K433D 433 K D 0.066 Neutral PMS2 P54278 K433E 433 K E 0.052 Neutral PMS2 P54278 K433F 433 K F 0.064 Neutral PMS2 P54278 K433G 433 K G 0.062 Neutral PMS2 P54278 K433H 433 K H 0.01 Neutral PMS2 P54278 K433I 433 K I 0.124 Neutral PMS2 P54278 K433L 433 K L 0.036 Neutral PMS2 P54278 K433M 433 K M 0.106 Neutral PMS2 P54278 K433N 433 K N 0.046 Neutral PMS2 P54278 K433P 433 K P 0.01 Neutral PMS2 P54278 K433Q 433 K Q 0.006 Neutral PMS2 P54278 K433R 433 K R 0.002 Neutral PMS2 P54278 K433S 433 K S 0.014 Neutral PMS2 P54278 K433T 433 K T 0.092 Neutral PMS2 P54278 K433V 433 K V 0.12 Neutral PMS2 P54278 K433W 433 K W 0.396 Neutral PMS2 P54278 K433Y 433 K Y 0.326 Neutral PMS2 P54278 P434A 434 P A 0.116 Neutral PMS2 P54278 P434C 434 P C 0.126 Neutral PMS2 P54278 P434D 434 P D 0.008 Neutral PMS2 P54278 P434E 434 P E 0.166 Neutral PMS2 P54278 P434F 434 P F 0.226 Neutral PMS2 P54278 P434G 434 P G 0.092 Neutral PMS2 P54278 P434H 434 P H 0.266 Neutral PMS2 P54278 P434I 434 P I 0.104 Neutral PMS2 P54278 P434K 434 P K 0.05 Neutral PMS2 P54278 P434L 434 P L 0.056 Neutral PMS2 P54278 P434M 434 P M 0.22 Neutral PMS2 P54278 P434N 434 P N 0.068 Neutral PMS2 P54278 P434Q 434 P Q 0.15 Neutral PMS2 P54278 P434R 434 P R 0.306 Neutral PMS2 P54278 P434S 434 P S 0.002 Neutral PMS2 P54278 P434T 434 P T 0.122 Neutral PMS2 P54278 P434V 434 P V 0.07 Neutral PMS2 P54278 P434W 434 P W 0.39 Neutral PMS2 P54278 P434Y 434 P Y 0.32 Neutral PMS2 P54278 H435A 435 H A 0.042 Neutral PMS2 P54278 H435C 435 H C 0.042 Neutral PMS2 P54278 H435D 435 H D 0 Neutral PMS2 P54278 H435E 435 H E 0.022 Neutral PMS2 P54278 H435F 435 H F 0.204 Neutral PMS2 P54278 H435G 435 H G 0.06 Neutral PMS2 P54278 H435I 435 H I 0.274 Neutral PMS2 P54278 H435K 435 H K 0.086 Neutral PMS2 P54278 H435L 435 H L 0.23 Neutral PMS2 P54278 H435M 435 H M 0.108 Neutral PMS2 P54278 H435N 435 H N 0.058 Neutral PMS2 P54278 H435P 435 H P 0.042 Neutral PMS2 P54278 H435Q 435 H Q 0.006 Neutral PMS2 P54278 H435R 435 H R 0 Neutral PMS2 P54278 H435S 435 H S 0.026 Neutral PMS2 P54278 H435T 435 H T 0.012 Neutral PMS2 P54278 H435V 435 H V 0.144 Neutral PMS2 P54278 H435W 435 H W 0.306 Neutral PMS2 P54278 H435Y 435 H Y 0.252 Neutral PMS2 P54278 S436A 436 S A 0.012 Neutral PMS2 P54278 S436C 436 S C 0.032 Neutral PMS2 P54278 S436D 436 S D 0.024 Neutral PMS2 P54278 S436E 436 S E 0.114 Neutral PMS2 P54278 S436F 436 S F 0.276 Neutral PMS2 P54278 S436G 436 S G 0 Neutral PMS2 P54278 S436H 436 S H 0.176 Neutral PMS2 P54278 S436I 436 S I 0.124 Neutral PMS2 P54278 S436K 436 S K 0.15 Neutral PMS2 P54278 S436L 436 S L 0.062 Neutral PMS2 P54278 S436M 436 S M 0.332 Neutral PMS2 P54278 S436N 436 S N 0 Neutral PMS2 P54278 S436P 436 S P 0.098 Neutral PMS2 P54278 S436Q 436 S Q 0.17 Neutral PMS2 P54278 S436R 436 S R 0.152 Neutral PMS2 P54278 S436T 436 S T 0.104 Neutral PMS2 P54278 S436V 436 S V 0.248 Neutral PMS2 P54278 S436W 436 S W 0.49 Neutral PMS2 P54278 S436Y 436 S Y 0.404 Neutral PMS2 P54278 P437A 437 P A 0.176 Neutral PMS2 P54278 P437C 437 P C 0.148 Neutral PMS2 P54278 P437D 437 P D 0.05 Neutral PMS2 P54278 P437E 437 P E 0.062 Neutral PMS2 P54278 P437F 437 P F 0.266 Neutral PMS2 P54278 P437G 437 P G 0.07 Neutral PMS2 P54278 P437H 437 P H 0.266 Neutral PMS2 P54278 P437I 437 P I 0.054 Neutral PMS2 P54278 P437K 437 P K 0.206 Neutral PMS2 P54278 P437L 437 P L 0.044 Neutral PMS2 P54278 P437M 437 P M 0.22 Neutral PMS2 P54278 P437N 437 P N 0.018 Neutral PMS2 P54278 P437Q 437 P Q 0.096 Neutral PMS2 P54278 P437R 437 P R 0.202 Neutral PMS2 P54278 P437S 437 P S 0.002 Neutral PMS2 P54278 P437T 437 P T 0.084 Neutral PMS2 P54278 P437V 437 P V 0.13 Neutral PMS2 P54278 P437W 437 P W 0.322 Neutral PMS2 P54278 P437Y 437 P Y 0.27 Neutral PMS2 P54278 K438A 438 K A 0.028 Neutral PMS2 P54278 K438C 438 K C 0.036 Neutral PMS2 P54278 K438D 438 K D 0.05 Neutral PMS2 P54278 K438E 438 K E 0.004 Neutral PMS2 P54278 K438F 438 K F 0.212 Neutral PMS2 P54278 K438G 438 K G 0.132 Neutral PMS2 P54278 K438H 438 K H 0.048 Neutral PMS2 P54278 K438I 438 K I 0.222 Neutral PMS2 P54278 K438L 438 K L 0.104 Neutral PMS2 P54278 K438M 438 K M 0.078 Neutral PMS2 P54278 K438N 438 K N 0.014 Neutral PMS2 P54278 K438P 438 K P 0.076 Neutral PMS2 P54278 K438Q 438 K Q 0.006 Neutral PMS2 P54278 K438R 438 K R 0.002 Neutral PMS2 P54278 K438S 438 K S 0.014 Neutral PMS2 P54278 K438T 438 K T 0.09 Neutral PMS2 P54278 K438V 438 K V 0.18 Neutral PMS2 P54278 K438W 438 K W 0.396 Neutral PMS2 P54278 K438Y 438 K Y 0.326 Neutral PMS2 P54278 T439A 439 T A 0.002 Neutral PMS2 P54278 T439C 439 T C 0.064 Neutral PMS2 P54278 T439D 439 T D 0.024 Neutral PMS2 P54278 T439E 439 T E 0.032 Neutral PMS2 P54278 T439F 439 T F 0.214 Neutral PMS2 P54278 T439G 439 T G 0.058 Neutral PMS2 P54278 T439H 439 T H 0.056 Neutral PMS2 P54278 T439I 439 T I 0.096 Neutral PMS2 P54278 T439K 439 T K 0.008 Neutral PMS2 P54278 T439L 439 T L 0.07 Neutral PMS2 P54278 T439M 439 T M 0.044 Neutral PMS2 P54278 T439N 439 T N 0.02 Neutral PMS2 P54278 T439P 439 T P 0.02 Neutral PMS2 P54278 T439Q 439 T Q 0.016 Neutral PMS2 P54278 T439R 439 T R 0.142 Neutral PMS2 P54278 T439S 439 T S 0 Neutral PMS2 P54278 T439V 439 T V 0.212 Neutral PMS2 P54278 T439W 439 T W 0.466 Neutral PMS2 P54278 T439Y 439 T Y 0.424 Neutral PMS2 P54278 E44A 44 E A 0.398 Neutral PMS2 P54278 E44C 44 E C 0.648 Pathogenic PMS2 P54278 E44D 44 E D 0.128 Neutral PMS2 P54278 E44F 44 E F 0.956 Pathogenic PMS2 P54278 E44G 44 E G 0.14 Neutral PMS2 P54278 E44H 44 E H 0.838 Pathogenic PMS2 P54278 E44I 44 E I 0.98 Pathogenic PMS2 P54278 E44K 44 E K 0.3 Neutral PMS2 P54278 E44L 44 E L 0.306 Neutral PMS2 P54278 E44M 44 E M 0.684 Pathogenic PMS2 P54278 E44N 44 E N 0.096 Neutral PMS2 P54278 E44P 44 E P 0.93 Pathogenic PMS2 P54278 E44Q 44 E Q 0.118 Neutral PMS2 P54278 E44R 44 E R 0.296 Neutral PMS2 P54278 E44S 44 E S 0.852 Pathogenic PMS2 P54278 E44T 44 E T 0.192 Neutral PMS2 P54278 E44V 44 E V 0.916 Pathogenic PMS2 P54278 E44W 44 E W 0.986 Pathogenic PMS2 P54278 E44Y 44 E Y 0.966 Pathogenic PMS2 P54278 P440A 440 P A 0.032 Neutral PMS2 P54278 P440C 440 P C 0.148 Neutral PMS2 P54278 P440D 440 P D 0.05 Neutral PMS2 P54278 P440E 440 P E 0.106 Neutral PMS2 P54278 P440F 440 P F 0.272 Neutral PMS2 P54278 P440G 440 P G 0.07 Neutral PMS2 P54278 P440H 440 P H 0.226 Neutral PMS2 P54278 P440I 440 P I 0.1 Neutral PMS2 P54278 P440K 440 P K 0.05 Neutral PMS2 P54278 P440L 440 P L 0.096 Neutral PMS2 P54278 P440M 440 P M 0.22 Neutral PMS2 P54278 P440N 440 P N 0.068 Neutral PMS2 P54278 P440Q 440 P Q 0.212 Neutral PMS2 P54278 P440R 440 P R 0.206 Neutral PMS2 P54278 P440S 440 P S 0.022 Neutral PMS2 P54278 P440T 440 P T 0.012 Neutral PMS2 P54278 P440V 440 P V 0.184 Neutral PMS2 P54278 P440W 440 P W 0.39 Neutral PMS2 P54278 P440Y 440 P Y 0.32 Neutral PMS2 P54278 E441A 441 E A 0.118 Neutral PMS2 P54278 E441C 441 E C 0.064 Neutral PMS2 P54278 E441D 441 E D 0 Neutral PMS2 P54278 E441F 441 E F 0.272 Neutral PMS2 P54278 E441G 441 E G 0 Neutral PMS2 P54278 E441H 441 E H 0.104 Neutral PMS2 P54278 E441I 441 E I 0.284 Neutral PMS2 P54278 E441K 441 E K 0.002 Neutral PMS2 P54278 E441L 441 E L 0.286 Neutral PMS2 P54278 E441M 441 E M 0.164 Neutral PMS2 P54278 E441N 441 E N 0.006 Neutral PMS2 P54278 E441P 441 E P 0.124 Neutral PMS2 P54278 E441Q 441 E Q 0.056 Neutral PMS2 P54278 E441R 441 E R 0.046 Neutral PMS2 P54278 E441S 441 E S 0.014 Neutral PMS2 P54278 E441T 441 E T 0.168 Neutral PMS2 P54278 E441V 441 E V 0.232 Neutral PMS2 P54278 E441W 441 E W 0.43 Neutral PMS2 P54278 E441Y 441 E Y 0.296 Neutral PMS2 P54278 P442A 442 P A 0.032 Neutral PMS2 P54278 P442C 442 P C 0.148 Neutral PMS2 P54278 P442D 442 P D 0.014 Neutral PMS2 P54278 P442E 442 P E 0.062 Neutral PMS2 P54278 P442F 442 P F 0.272 Neutral PMS2 P54278 P442G 442 P G 0.092 Neutral PMS2 P54278 P442H 442 P H 0.226 Neutral PMS2 P54278 P442I 442 P I 0.104 Neutral PMS2 P54278 P442K 442 P K 0.206 Neutral PMS2 P54278 P442L 442 P L 0.044 Neutral PMS2 P54278 P442M 442 P M 0.22 Neutral PMS2 P54278 P442N 442 P N 0.048 Neutral PMS2 P54278 P442Q 442 P Q 0.052 Neutral PMS2 P54278 P442R 442 P R 0.204 Neutral PMS2 P54278 P442S 442 P S 0.092 Neutral PMS2 P54278 P442T 442 P T 0.188 Neutral PMS2 P54278 P442V 442 P V 0.14 Neutral PMS2 P54278 P442W 442 P W 0.39 Neutral PMS2 P54278 P442Y 442 P Y 0.32 Neutral PMS2 P54278 R443A 443 R A 0.086 Neutral PMS2 P54278 R443C 443 R C 0.074 Neutral PMS2 P54278 R443D 443 R D 0.074 Neutral PMS2 P54278 R443E 443 R E 0.128 Neutral PMS2 P54278 R443F 443 R F 0.28 Neutral PMS2 P54278 R443G 443 R G 0.038 Neutral PMS2 P54278 R443H 443 R H 0.12 Neutral PMS2 P54278 R443I 443 R I 0.304 Neutral PMS2 P54278 R443K 443 R K 0.004 Neutral PMS2 P54278 R443L 443 R L 0.23 Neutral PMS2 P54278 R443M 443 R M 0.164 Neutral PMS2 P54278 R443N 443 R N 0.198 Neutral PMS2 P54278 R443P 443 R P 0.236 Neutral PMS2 P54278 R443Q 443 R Q 0.012 Neutral PMS2 P54278 R443S 443 R S 0.016 Neutral PMS2 P54278 R443T 443 R T 0.016 Neutral PMS2 P54278 R443V 443 R V 0.242 Neutral PMS2 P54278 R443W 443 R W 0.384 Neutral PMS2 P54278 R443Y 443 R Y 0.284 Neutral PMS2 P54278 R444A 444 R A 0.08 Neutral PMS2 P54278 R444C 444 R C 0.074 Neutral PMS2 P54278 R444D 444 R D 0.18 Neutral PMS2 P54278 R444E 444 R E 0.162 Neutral PMS2 P54278 R444F 444 R F 0.28 Neutral PMS2 P54278 R444G 444 R G 0.1 Neutral PMS2 P54278 R444H 444 R H 0.12 Neutral PMS2 P54278 R444I 444 R I 0.304 Neutral PMS2 P54278 R444K 444 R K 0.004 Neutral PMS2 P54278 R444L 444 R L 0.272 Neutral PMS2 P54278 R444M 444 R M 0.066 Neutral PMS2 P54278 R444N 444 R N 0.01 Neutral PMS2 P54278 R444P 444 R P 0.236 Neutral PMS2 P54278 R444Q 444 R Q 0.01 Neutral PMS2 P54278 R444S 444 R S 0.062 Neutral PMS2 P54278 R444T 444 R T 0.026 Neutral PMS2 P54278 R444V 444 R V 0.178 Neutral PMS2 P54278 R444W 444 R W 0.198 Neutral PMS2 P54278 R444Y 444 R Y 0.284 Neutral PMS2 P54278 S445A 445 S A 0.052 Neutral PMS2 P54278 S445C 445 S C 0.022 Neutral PMS2 P54278 S445D 445 S D 0.024 Neutral PMS2 P54278 S445E 445 S E 0.114 Neutral PMS2 P54278 S445F 445 S F 0.264 Neutral PMS2 P54278 S445G 445 S G 0.002 Neutral PMS2 P54278 S445H 445 S H 0.238 Neutral PMS2 P54278 S445I 445 S I 0.194 Neutral PMS2 P54278 S445K 445 S K 0.15 Neutral PMS2 P54278 S445L 445 S L 0.032 Neutral PMS2 P54278 S445M 445 S M 0.332 Neutral PMS2 P54278 S445N 445 S N 0 Neutral PMS2 P54278 S445P 445 S P 0.066 Neutral PMS2 P54278 S445Q 445 S Q 0.158 Neutral PMS2 P54278 S445R 445 S R 0.17 Neutral PMS2 P54278 S445T 445 S T 0.11 Neutral PMS2 P54278 S445V 445 S V 0.03 Neutral PMS2 P54278 S445W 445 S W 0.49 Neutral PMS2 P54278 S445Y 445 S Y 0.448 Neutral PMS2 P54278 P446A 446 P A 0.116 Neutral PMS2 P54278 P446C 446 P C 0.126 Neutral PMS2 P54278 P446D 446 P D 0.008 Neutral PMS2 P54278 P446E 446 P E 0.166 Neutral PMS2 P54278 P446F 446 P F 0.248 Neutral PMS2 P54278 P446G 446 P G 0.01 Neutral PMS2 P54278 P446H 446 P H 0.266 Neutral PMS2 P54278 P446I 446 P I 0.104 Neutral PMS2 P54278 P446K 446 P K 0.052 Neutral PMS2 P54278 P446L 446 P L 0.094 Neutral PMS2 P54278 P446M 446 P M 0.178 Neutral PMS2 P54278 P446N 446 P N 0.018 Neutral PMS2 P54278 P446Q 446 P Q 0.052 Neutral PMS2 P54278 P446R 446 P R 0.306 Neutral PMS2 P54278 P446S 446 P S 0.002 Neutral PMS2 P54278 P446T 446 P T 0.084 Neutral PMS2 P54278 P446V 446 P V 0.184 Neutral PMS2 P54278 P446W 446 P W 0.39 Neutral PMS2 P54278 P446Y 446 P Y 0.244 Neutral PMS2 P54278 L447A 447 L A 0.064 Neutral PMS2 P54278 L447C 447 L C 0.094 Neutral PMS2 P54278 L447D 447 L D 0.162 Neutral PMS2 P54278 L447E 447 L E 0.148 Neutral PMS2 P54278 L447F 447 L F 0.214 Neutral PMS2 P54278 L447G 447 L G 0.188 Neutral PMS2 P54278 L447H 447 L H 0.042 Neutral PMS2 P54278 L447I 447 L I 0.072 Neutral PMS2 P54278 L447K 447 L K 0.044 Neutral PMS2 P54278 L447M 447 L M 0.132 Neutral PMS2 P54278 L447N 447 L N 0.042 Neutral PMS2 P54278 L447P 447 L P 0.088 Neutral PMS2 P54278 L447Q 447 L Q 0.004 Neutral PMS2 P54278 L447R 447 L R 0.254 Neutral PMS2 P54278 L447S 447 L S 0.136 Neutral PMS2 P54278 L447T 447 L T 0.182 Neutral PMS2 P54278 L447V 447 L V 0.08 Neutral PMS2 P54278 L447W 447 L W 0.344 Neutral PMS2 P54278 L447Y 447 L Y 0.298 Neutral PMS2 P54278 G448A 448 G A 0.018 Neutral PMS2 P54278 G448C 448 G C 0.132 Neutral PMS2 P54278 G448D 448 G D 0.244 Neutral PMS2 P54278 G448E 448 G E 0.166 Neutral PMS2 P54278 G448F 448 G F 0.498 Neutral PMS2 P54278 G448H 448 G H 0.37 Neutral PMS2 P54278 G448I 448 G I 0.428 Neutral PMS2 P54278 G448K 448 G K 0.286 Neutral PMS2 P54278 G448L 448 G L 0.332 Neutral PMS2 P54278 G448M 448 G M 0.422 Neutral PMS2 P54278 G448N 448 G N 0.162 Neutral PMS2 P54278 G448P 448 G P 0.35 Neutral PMS2 P54278 G448Q 448 G Q 0.208 Neutral PMS2 P54278 G448R 448 G R 0.302 Neutral PMS2 P54278 G448S 448 G S 0.018 Neutral PMS2 P54278 G448T 448 G T 0.272 Neutral PMS2 P54278 G448V 448 G V 0.394 Neutral PMS2 P54278 G448W 448 G W 0.498 Neutral PMS2 P54278 G448Y 448 G Y 0.5 Pathogenic PMS2 P54278 Q449A 449 Q A 0.1 Neutral PMS2 P54278 Q449C 449 Q C 0.048 Neutral PMS2 P54278 Q449D 449 Q D 0.088 Neutral PMS2 P54278 Q449E 449 Q E 0.008 Neutral PMS2 P54278 Q449F 449 Q F 0.26 Neutral PMS2 P54278 Q449G 449 Q G 0.116 Neutral PMS2 P54278 Q449H 449 Q H 0.034 Neutral PMS2 P54278 Q449I 449 Q I 0.354 Neutral PMS2 P54278 Q449K 449 Q K 0.02 Neutral PMS2 P54278 Q449L 449 Q L 0.214 Neutral PMS2 P54278 Q449M 449 Q M 0.186 Neutral PMS2 P54278 Q449N 449 Q N 0.094 Neutral PMS2 P54278 Q449P 449 Q P 0.22 Neutral PMS2 P54278 Q449R 449 Q R 0.008 Neutral PMS2 P54278 Q449S 449 Q S 0.038 Neutral PMS2 P54278 Q449T 449 Q T 0.13 Neutral PMS2 P54278 Q449V 449 Q V 0.26 Neutral PMS2 P54278 Q449W 449 Q W 0.42 Neutral PMS2 P54278 Q449Y 449 Q Y 0.362 Neutral PMS2 P54278 N45A 45 N A 0.342 Neutral PMS2 P54278 N45C 45 N C 0.378 Neutral PMS2 P54278 N45D 45 N D 0.768 Pathogenic PMS2 P54278 N45E 45 N E 0.238 Neutral PMS2 P54278 N45F 45 N F 0.654 Pathogenic PMS2 P54278 N45G 45 N G 0.836 Pathogenic PMS2 P54278 N45H 45 N H 0.564 Pathogenic PMS2 P54278 N45I 45 N I 0.602 Pathogenic PMS2 P54278 N45K 45 N K 0.47 Neutral PMS2 P54278 N45L 45 N L 0.36 Neutral PMS2 P54278 N45M 45 N M 0.938 Pathogenic PMS2 P54278 N45P 45 N P 0.75 Pathogenic PMS2 P54278 N45Q 45 N Q 0.246 Neutral PMS2 P54278 N45R 45 N R 0.886 Pathogenic PMS2 P54278 N45S 45 N S 0.222 Neutral PMS2 P54278 N45T 45 N T 0.178 Neutral PMS2 P54278 N45V 45 N V 0.478 Neutral PMS2 P54278 N45W 45 N W 0.966 Pathogenic PMS2 P54278 N45Y 45 N Y 0.932 Pathogenic PMS2 P54278 K450A 450 K A 0.028 Neutral PMS2 P54278 K450C 450 K C 0.028 Neutral PMS2 P54278 K450D 450 K D 0.05 Neutral PMS2 P54278 K450E 450 K E 0.01 Neutral PMS2 P54278 K450F 450 K F 0.212 Neutral PMS2 P54278 K450G 450 K G 0.13 Neutral PMS2 P54278 K450H 450 K H 0.018 Neutral PMS2 P54278 K450I 450 K I 0.124 Neutral PMS2 P54278 K450L 450 K L 0.214 Neutral PMS2 P54278 K450M 450 K M 0.146 Neutral PMS2 P54278 K450N 450 K N 0.006 Neutral PMS2 P54278 K450P 450 K P 0.076 Neutral PMS2 P54278 K450Q 450 K Q 0.09 Neutral PMS2 P54278 K450R 450 K R 0.002 Neutral PMS2 P54278 K450S 450 K S 0.012 Neutral PMS2 P54278 K450T 450 K T 0.18 Neutral PMS2 P54278 K450V 450 K V 0.12 Neutral PMS2 P54278 K450W 450 K W 0.396 Neutral PMS2 P54278 K450Y 450 K Y 0.326 Neutral PMS2 P54278 R451A 451 R A 0.08 Neutral PMS2 P54278 R451C 451 R C 0.074 Neutral PMS2 P54278 R451D 451 R D 0.18 Neutral PMS2 P54278 R451E 451 R E 0.02 Neutral PMS2 P54278 R451F 451 R F 0.28 Neutral PMS2 P54278 R451G 451 R G 0.002 Neutral PMS2 P54278 R451H 451 R H 0.004 Neutral PMS2 P54278 R451I 451 R I 0.194 Neutral PMS2 P54278 R451K 451 R K 0.168 Neutral PMS2 P54278 R451L 451 R L 0.012 Neutral PMS2 P54278 R451M 451 R M 0.164 Neutral PMS2 P54278 R451N 451 R N 0.176 Neutral PMS2 P54278 R451P 451 R P 0.028 Neutral PMS2 P54278 R451Q 451 R Q 0.012 Neutral PMS2 P54278 R451S 451 R S 0.016 Neutral PMS2 P54278 R451T 451 R T 0.142 Neutral PMS2 P54278 R451V 451 R V 0.242 Neutral PMS2 P54278 R451W 451 R W 0.384 Neutral PMS2 P54278 R451Y 451 R Y 0.182 Neutral PMS2 P54278 G452A 452 G A 0.004 Neutral PMS2 P54278 G452C 452 G C 0.14 Neutral PMS2 P54278 G452D 452 G D 0.134 Neutral PMS2 P54278 G452E 452 G E 0.19 Neutral PMS2 P54278 G452F 452 G F 0.498 Neutral PMS2 P54278 G452H 452 G H 0.442 Neutral PMS2 P54278 G452I 452 G I 0.394 Neutral PMS2 P54278 G452K 452 G K 0.284 Neutral PMS2 P54278 G452L 452 G L 0.37 Neutral PMS2 P54278 G452M 452 G M 0.34 Neutral PMS2 P54278 G452N 452 G N 0.172 Neutral PMS2 P54278 G452P 452 G P 0.372 Neutral PMS2 P54278 G452Q 452 G Q 0.192 Neutral PMS2 P54278 G452R 452 G R 0.324 Neutral PMS2 P54278 G452S 452 G S 0.018 Neutral PMS2 P54278 G452T 452 G T 0.274 Neutral PMS2 P54278 G452V 452 G V 0.318 Neutral PMS2 P54278 G452W 452 G W 0.488 Neutral PMS2 P54278 G452Y 452 G Y 0.5 Pathogenic PMS2 P54278 M453A 453 M A 0.076 Neutral PMS2 P54278 M453C 453 M C 0.042 Neutral PMS2 P54278 M453D 453 M D 0.162 Neutral PMS2 P54278 M453E 453 M E 0.014 Neutral PMS2 P54278 M453F 453 M F 0.136 Neutral PMS2 P54278 M453G 453 M G 0.118 Neutral PMS2 P54278 M453H 453 M H 0.026 Neutral PMS2 P54278 M453I 453 M I 0.06 Neutral PMS2 P54278 M453K 453 M K 0.016 Neutral PMS2 P54278 M453L 453 M L 0.004 Neutral PMS2 P54278 M453N 453 M N 0.186 Neutral PMS2 P54278 M453P 453 M P 0.032 Neutral PMS2 P54278 M453Q 453 M Q 0.002 Neutral PMS2 P54278 M453R 453 M R 0.042 Neutral PMS2 P54278 M453S 453 M S 0.008 Neutral PMS2 P54278 M453T 453 M T 0.008 Neutral PMS2 P54278 M453V 453 M V 0.068 Neutral PMS2 P54278 M453W 453 M W 0.422 Neutral PMS2 P54278 M453Y 453 M Y 0.348 Neutral PMS2 P54278 L454A 454 L A 0.064 Neutral PMS2 P54278 L454C 454 L C 0.014 Neutral PMS2 P54278 L454D 454 L D 0.156 Neutral PMS2 P54278 L454E 454 L E 0.106 Neutral PMS2 P54278 L454F 454 L F 0.12 Neutral PMS2 P54278 L454G 454 L G 0.184 Neutral PMS2 P54278 L454H 454 L H 0.084 Neutral PMS2 P54278 L454I 454 L I 0.072 Neutral PMS2 P54278 L454K 454 L K 0.084 Neutral PMS2 P54278 L454M 454 L M 0.132 Neutral PMS2 P54278 L454N 454 L N 0.148 Neutral PMS2 P54278 L454P 454 L P 0.086 Neutral PMS2 P54278 L454Q 454 L Q 0.018 Neutral PMS2 P54278 L454R 454 L R 0.25 Neutral PMS2 P54278 L454S 454 L S 0.01 Neutral PMS2 P54278 L454T 454 L T 0.18 Neutral PMS2 P54278 L454V 454 L V 0.114 Neutral PMS2 P54278 L454W 454 L W 0.334 Neutral PMS2 P54278 L454Y 454 L Y 0.282 Neutral PMS2 P54278 S455A 455 S A 0.01 Neutral PMS2 P54278 S455C 455 S C 0.002 Neutral PMS2 P54278 S455D 455 S D 0.008 Neutral PMS2 P54278 S455E 455 S E 0.124 Neutral PMS2 P54278 S455F 455 S F 0.264 Neutral PMS2 P54278 S455G 455 S G 0.064 Neutral PMS2 P54278 S455H 455 S H 0.176 Neutral PMS2 P54278 S455I 455 S I 0.026 Neutral PMS2 P54278 S455K 455 S K 0.164 Neutral PMS2 P54278 S455L 455 S L 0.042 Neutral PMS2 P54278 S455M 455 S M 0.28 Neutral PMS2 P54278 S455N 455 S N 0.018 Neutral PMS2 P54278 S455P 455 S P 0.056 Neutral PMS2 P54278 S455Q 455 S Q 0.158 Neutral PMS2 P54278 S455R 455 S R 0.154 Neutral PMS2 P54278 S455T 455 S T 0.176 Neutral PMS2 P54278 S455V 455 S V 0.248 Neutral PMS2 P54278 S455W 455 S W 0.49 Neutral PMS2 P54278 S455Y 455 S Y 0.448 Neutral PMS2 P54278 S456A 456 S A 0.018 Neutral PMS2 P54278 S456C 456 S C 0.002 Neutral PMS2 P54278 S456D 456 S D 0.024 Neutral PMS2 P54278 S456E 456 S E 0.114 Neutral PMS2 P54278 S456F 456 S F 0.266 Neutral PMS2 P54278 S456G 456 S G 0 Neutral PMS2 P54278 S456H 456 S H 0.176 Neutral PMS2 P54278 S456I 456 S I 0.124 Neutral PMS2 P54278 S456K 456 S K 0.15 Neutral PMS2 P54278 S456L 456 S L 0.034 Neutral PMS2 P54278 S456M 456 S M 0.28 Neutral PMS2 P54278 S456N 456 S N 0.034 Neutral PMS2 P54278 S456P 456 S P 0.132 Neutral PMS2 P54278 S456Q 456 S Q 0.188 Neutral PMS2 P54278 S456R 456 S R 0.138 Neutral PMS2 P54278 S456T 456 S T 0.104 Neutral PMS2 P54278 S456V 456 S V 0.288 Neutral PMS2 P54278 S456W 456 S W 0.49 Neutral PMS2 P54278 S456Y 456 S Y 0.414 Neutral PMS2 P54278 S457A 457 S A 0.01 Neutral PMS2 P54278 S457C 457 S C 0.022 Neutral PMS2 P54278 S457D 457 S D 0.024 Neutral PMS2 P54278 S457E 457 S E 0.124 Neutral PMS2 P54278 S457F 457 S F 0.264 Neutral PMS2 P54278 S457G 457 S G 0.01 Neutral PMS2 P54278 S457H 457 S H 0.238 Neutral PMS2 P54278 S457I 457 S I 0.196 Neutral PMS2 P54278 S457K 457 S K 0.164 Neutral PMS2 P54278 S457L 457 S L 0.032 Neutral PMS2 P54278 S457M 457 S M 0.272 Neutral PMS2 P54278 S457N 457 S N 0.034 Neutral PMS2 P54278 S457P 457 S P 0.064 Neutral PMS2 P54278 S457Q 457 S Q 0.132 Neutral PMS2 P54278 S457R 457 S R 0.152 Neutral PMS2 P54278 S457T 457 S T 0.02 Neutral PMS2 P54278 S457V 457 S V 0.068 Neutral PMS2 P54278 S457W 457 S W 0.49 Neutral PMS2 P54278 S457Y 457 S Y 0.448 Neutral PMS2 P54278 T458A 458 T A 0 Neutral PMS2 P54278 T458C 458 T C 0.03 Neutral PMS2 P54278 T458D 458 T D 0.038 Neutral PMS2 P54278 T458E 458 T E 0.032 Neutral PMS2 P54278 T458F 458 T F 0.204 Neutral PMS2 P54278 T458G 458 T G 0.014 Neutral PMS2 P54278 T458H 458 T H 0.084 Neutral PMS2 P54278 T458I 458 T I 0.066 Neutral PMS2 P54278 T458K 458 T K 0.026 Neutral PMS2 P54278 T458L 458 T L 0.008 Neutral PMS2 P54278 T458M 458 T M 0.044 Neutral PMS2 P54278 T458N 458 T N 0.012 Neutral PMS2 P54278 T458P 458 T P 0.008 Neutral PMS2 P54278 T458Q 458 T Q 0.052 Neutral PMS2 P54278 T458R 458 T R 0.156 Neutral PMS2 P54278 T458S 458 T S 0 Neutral PMS2 P54278 T458V 458 T V 0.212 Neutral PMS2 P54278 T458W 458 T W 0.466 Neutral PMS2 P54278 T458Y 458 T Y 0.424 Neutral PMS2 P54278 S459A 459 S A 0.068 Neutral PMS2 P54278 S459C 459 S C 0.032 Neutral PMS2 P54278 S459D 459 S D 0.002 Neutral PMS2 P54278 S459E 459 S E 0.114 Neutral PMS2 P54278 S459F 459 S F 0.262 Neutral PMS2 P54278 S459G 459 S G 0 Neutral PMS2 P54278 S459H 459 S H 0.17 Neutral PMS2 P54278 S459I 459 S I 0.026 Neutral PMS2 P54278 S459K 459 S K 0.15 Neutral PMS2 P54278 S459L 459 S L 0.032 Neutral PMS2 P54278 S459M 459 S M 0.332 Neutral PMS2 P54278 S459N 459 S N 0.004 Neutral PMS2 P54278 S459P 459 S P 0.132 Neutral PMS2 P54278 S459Q 459 S Q 0.132 Neutral PMS2 P54278 S459R 459 S R 0.17 Neutral PMS2 P54278 S459T 459 S T 0.11 Neutral PMS2 P54278 S459V 459 S V 0.032 Neutral PMS2 P54278 S459W 459 S W 0.49 Neutral PMS2 P54278 S459Y 459 S Y 0.434 Neutral PMS2 P54278 S46A 46 S A 0.166 Neutral PMS2 P54278 S46C 46 S C 0.486 Neutral PMS2 P54278 S46D 46 S D 0.796 Pathogenic PMS2 P54278 S46E 46 S E 0.908 Pathogenic PMS2 P54278 S46F 46 S F 0.7 Pathogenic PMS2 P54278 S46G 46 S G 0.14 Neutral PMS2 P54278 S46H 46 S H 0.922 Pathogenic PMS2 P54278 S46I 46 S I 0.708 Pathogenic 4 PMS2 P54278 S46K 46 S K 0.896 Pathogenic PMS2 P54278 S46L 46 S L 0.476 Neutral PMS2 P54278 S46M 46 S M 0.994 Pathogenic PMS2 P54278 S46N 46 S N 0.748 Pathogenic PMS2 P54278 S46P 46 S P 0.912 Pathogenic PMS2 P54278 S46Q 46 S Q 0.866 Pathogenic PMS2 P54278 S46R 46 S R 0.93 Pathogenic PMS2 P54278 S46T 46 S T 0.812 Pathogenic PMS2 P54278 S46V 46 S V 0.336 Neutral PMS2 P54278 S46W 46 S W 0.968 Pathogenic PMS2 P54278 S46Y 46 S Y 0.966 Pathogenic PMS2 P54278 G460A 460 G A 0.002 Neutral PMS2 P54278 G460C 460 G C 0.14 Neutral PMS2 P54278 G460D 460 G D 0.134 Neutral PMS2 P54278 G460E 460 G E 0.304 Neutral PMS2 P54278 G460F 460 G F 0.478 Neutral PMS2 P54278 G460H 460 G H 0.37 Neutral PMS2 P54278 G460I 460 G I 0.428 Neutral PMS2 P54278 G460K 460 G K 0.358 Neutral PMS2 P54278 G460L 460 G L 0.326 Neutral PMS2 P54278 G460M 460 G M 0.422 Neutral PMS2 P54278 G460N 460 G N 0.252 Neutral PMS2 P54278 G460P 460 G P 0.358 Neutral PMS2 P54278 G460Q 460 G Q 0.194 Neutral PMS2 P54278 G460R 460 G R 0.468 Neutral PMS2 P54278 G460S 460 G S 0.016 Neutral PMS2 P54278 G460T 460 G T 0.25 Neutral PMS2 P54278 G460V 460 G V 0.344 Neutral PMS2 P54278 G460W 460 G W 0.498 Neutral PMS2 P54278 G460Y 460 G Y 0.5 Pathogenic PMS2 P54278 A461C 461 A C 0.096 Neutral PMS2 P54278 A461D 461 A D 0.266 Neutral PMS2 P54278 A461E 461 A E 0.286 Neutral PMS2 P54278 A461F 461 A F 0.468 Neutral PMS2 P54278 A461G 461 A G 0.154 Neutral PMS2 P54278 A461H 461 A H 0.26 Neutral PMS2 P54278 A461I 461 A I 0.348 Neutral PMS2 P54278 A461K 461 A K 0.29 Neutral PMS2 P54278 A461L 461 A L 0.312 Neutral PMS2 P54278 A461M 461 A M 0.29 Neutral PMS2 P54278 A461N 461 A N 0.31 Neutral PMS2 P54278 A461P 461 A P 0.036 Neutral PMS2 P54278 A461Q 461 A Q 0.286 Neutral PMS2 P54278 A461R 461 A R 0.36 Neutral PMS2 P54278 A461S 461 A S 0.008 Neutral PMS2 P54278 A461T 461 A T 0.012 Neutral PMS2 P54278 A461V 461 A V 0.136 Neutral PMS2 P54278 A461W 461 A W 0.504 Pathogenic PMS2 P54278 A461Y 461 A Y 0.5 Pathogenic PMS2 P54278 I462A 462 I A 0.072 Neutral PMS2 P54278 I462C 462 I C 0.012 Neutral PMS2 P54278 I462D 462 I D 0.166 Neutral PMS2 P54278 I462E 462 I E 0.14 Neutral PMS2 P54278 I462F 462 I F 0.218 Neutral PMS2 P54278 I462G 462 I G 0.192 Neutral PMS2 P54278 I462H 462 I H 0.03 Neutral PMS2 P54278 I462K 462 I K 0.042 Neutral PMS2 P54278 I462L 462 I L 0.108 Neutral PMS2 P54278 I462M 462 I M 0.112 Neutral PMS2 P54278 I462N 462 I N 0.158 Neutral PMS2 P54278 I462P 462 I P 0.096 Neutral PMS2 P54278 I462Q 462 I Q 0.108 Neutral PMS2 P54278 I462R 462 I R 0.26 Neutral PMS2 P54278 I462S 462 I S 0.072 Neutral PMS2 P54278 I462T 462 I T 0.002 Neutral PMS2 P54278 I462V 462 I V 0 Neutral PMS2 P54278 I462W 462 I W 0.344 Neutral PMS2 P54278 I462Y 462 I Y 0.298 Neutral PMS2 P54278 S463A 463 S A 0.086 Neutral PMS2 P54278 S463C 463 S C 0.032 Neutral PMS2 P54278 S463D 463 S D 0.002 Neutral PMS2 P54278 S463E 463 S E 0.136 Neutral PMS2 P54278 S463F 463 S F 0.306 Neutral PMS2 P54278 S463G 463 S G 0.036 Neutral PMS2 P54278 S463H 463 S H 0.214 Neutral PMS2 P54278 S463I 463 S I 0.03 Neutral PMS2 P54278 S463K 463 S K 0.164 Neutral PMS2 P54278 S463L 463 S L 0.066 Neutral PMS2 P54278 S463M 463 S M 0.382 Neutral PMS2 P54278 S463N 463 S N 0 Neutral PMS2 P54278 S463P 463 S P 0.062 Neutral PMS2 P54278 S463Q 463 S Q 0.154 Neutral PMS2 P54278 S463R 463 S R 0.198 Neutral PMS2 P54278 S463T 463 S T 0.046 Neutral PMS2 P54278 S463V 463 S V 0.3 Neutral PMS2 P54278 S463W 463 S W 0.53 Pathogenic PMS2 P54278 S463Y 463 S Y 0.486 Neutral PMS2 P54278 D464A 464 D A 0.1 Neutral PMS2 P54278 D464C 464 D C 0.124 Neutral PMS2 P54278 D464E 464 D E 0.038 Neutral PMS2 P54278 D464F 464 D F 0.37 Neutral PMS2 P54278 D464G 464 D G 0.018 Neutral PMS2 P54278 D464H 464 D H 0.154 Neutral PMS2 P54278 D464I 464 D I 0.262 Neutral PMS2 P54278 D464K 464 D K 0.02 Neutral PMS2 P54278 D464L 464 D L 0.262 Neutral PMS2 P54278 D464M 464 D M 0.19 Neutral PMS2 P54278 D464N 464 D N 0.012 Neutral PMS2 P54278 D464P 464 D P 0.31 Neutral PMS2 P54278 D464Q 464 D Q 0.032 Neutral PMS2 P54278 D464R 464 D R 0.128 Neutral PMS2 P54278 D464S 464 D S 0.002 Neutral PMS2 P54278 D464T 464 D T 0.154 Neutral PMS2 P54278 D464V 464 D V 0.188 Neutral PMS2 P54278 D464W 464 D W 0.434 Neutral PMS2 P54278 D464Y 464 D Y 0.338 Neutral PMS2 P54278 K465A 465 K A 0.056 Neutral PMS2 P54278 K465C 465 K C 0.036 Neutral PMS2 P54278 K465D 465 K D 0.002 Neutral PMS2 P54278 K465E 465 K E 0.004 Neutral PMS2 P54278 K465F 465 K F 0.212 Neutral PMS2 P54278 K465G 465 K G 0.116 Neutral PMS2 P54278 K465H 465 K H 0.048 Neutral PMS2 P54278 K465I 465 K I 0.19 Neutral PMS2 P54278 K465L 465 K L 0.104 Neutral PMS2 P54278 K465M 465 K M 0.106 Neutral PMS2 P54278 K465N 465 K N 0.05 Neutral PMS2 P54278 K465P 465 K P 0.236 Neutral PMS2 P54278 K465Q 465 K Q 0.048 Neutral PMS2 P54278 K465R 465 K R 0.002 Neutral PMS2 P54278 K465S 465 K S 0.024 Neutral PMS2 P54278 K465T 465 K T 0.014 Neutral PMS2 P54278 K465V 465 K V 0.18 Neutral PMS2 P54278 K465W 465 K W 0.308 Neutral PMS2 P54278 K465Y 465 K Y 0.326 Neutral PMS2 P54278 G466A 466 G A 0.002 Neutral PMS2 P54278 G466C 466 G C 0.14 Neutral PMS2 P54278 G466D 466 G D 0.138 Neutral PMS2 P54278 G466E 466 G E 0.188 Neutral PMS2 P54278 G466F 466 G F 0.498 Neutral PMS2 P54278 G466H 466 G H 0.37 Neutral PMS2 P54278 G466I 466 G I 0.428 Neutral PMS2 P54278 G466K 466 G K 0.358 Neutral PMS2 P54278 G466L 466 G L 0.412 Neutral PMS2 P54278 G466M 466 G M 0.422 Neutral PMS2 P54278 G466N 466 G N 0.172 Neutral PMS2 P54278 G466P 466 G P 0.372 Neutral PMS2 P54278 G466Q 466 G Q 0.18 Neutral PMS2 P54278 G466R 466 G R 0.362 Neutral PMS2 P54278 G466S 466 G S 0.018 Neutral PMS2 P54278 G466T 466 G T 0.26 Neutral PMS2 P54278 G466V 466 G V 0.344 Neutral PMS2 P54278 G466W 466 G W 0.498 Neutral PMS2 P54278 G466Y 466 G Y 0.5 Pathogenic PMS2 P54278 V467A 467 V A 0.052 Neutral PMS2 P54278 V467C 467 V C 0.038 Neutral PMS2 P54278 V467D 467 V D 0.122 Neutral PMS2 P54278 V467E 467 V E 0.046 Neutral PMS2 P54278 V467F 467 V F 0.166 Neutral PMS2 P54278 V467G 467 V G 0.196 Neutral PMS2 P54278 V467H 467 V H 0.112 Neutral PMS2 P54278 V467I 467 V I 0.06 Neutral PMS2 P54278 V467K 467 V K 0.116 Neutral PMS2 P54278 V467L 467 V L 0 Neutral PMS2 P54278 V467M 467 V M 0.034 Neutral PMS2 P54278 V467N 467 V N 0.138 Neutral PMS2 P54278 V467P 467 V P 0.19 Neutral PMS2 P54278 V467Q 467 V Q 0.052 Neutral PMS2 P54278 V467R 467 V R 0.274 Neutral PMS2 P54278 V467S 467 V S 0.01 Neutral PMS2 P54278 V467T 467 V T 0.03 Neutral PMS2 P54278 V467W 467 V W 0.202 Neutral PMS2 P54278 V467Y 467 V Y 0.256 Neutral PMS2 P54278 L468A 468 L A 0.088 Neutral PMS2 P54278 L468C 468 L C 0.006 Neutral PMS2 P54278 L468D 468 L D 0.054 Neutral PMS2 P54278 L468E 468 L E 0.028 Neutral PMS2 P54278 L468F 468 L F 0.204 Neutral PMS2 P54278 L468G 468 L G 0.08 Neutral PMS2 P54278 L468H 468 L H 0.084 Neutral PMS2 P54278 L468I 468 L I 0.072 Neutral PMS2 P54278 L468K 468 L K 0.022 Neutral PMS2 P54278 L468M 468 L M 0.132 Neutral PMS2 P54278 L468N 468 L N 0.148 Neutral PMS2 P54278 L468P 468 L P 0.136 Neutral PMS2 P54278 L468Q 468 L Q 0.018 Neutral PMS2 P54278 L468R 468 L R 0.236 Neutral PMS2 P54278 L468S 468 L S 0.01 Neutral PMS2 P54278 L468T 468 L T 0.03 Neutral PMS2 P54278 L468V 468 L V 0.08 Neutral PMS2 P54278 L468W 468 L W 0.334 Neutral PMS2 P54278 L468Y 468 L Y 0.284 Neutral PMS2 P54278 R469A 469 R A 0.086 Neutral PMS2 P54278 R469C 469 R C 0.074 Neutral PMS2 P54278 R469D 469 R D 0.02 Neutral PMS2 P54278 R469E 469 R E 0.022 Neutral PMS2 P54278 R469F 469 R F 0.28 Neutral PMS2 P54278 R469G 469 R G 0.002 Neutral PMS2 P54278 R469H 469 R H 0.12 Neutral PMS2 P54278 R469I 469 R I 0.304 Neutral PMS2 P54278 R469K 469 R K 0.022 Neutral PMS2 P54278 R469L 469 R L 0.23 Neutral PMS2 P54278 R469M 469 R M 0.164 Neutral PMS2 P54278 R469N 469 R N 0.176 Neutral PMS2 P54278 R469P 469 R P 0.236 Neutral PMS2 P54278 R469Q 469 R Q 0.16 Neutral PMS2 P54278 R469S 469 R S 0.016 Neutral PMS2 P54278 R469T 469 R T 0.016 Neutral PMS2 P54278 R469V 469 R V 0.094 Neutral PMS2 P54278 R469W 469 R W 0.384 Neutral PMS2 P54278 R469Y 469 R Y 0.284 Neutral PMS2 P54278 L47A 47 L A 0.066 Neutral PMS2 P54278 L47C 47 L C 0.2 Neutral PMS2 P54278 L47D 47 L D 0.16 Neutral PMS2 P54278 L47E 47 L E 0.234 Neutral PMS2 P54278 L47F 47 L F 0.778 Pathogenic PMS2 P54278 L47G 47 L G 0.514 Pathogenic PMS2 P54278 L47H 47 L H 0.124 Neutral PMS2 P54278 L47I 47 L I 0.056 Neutral PMS2 P54278 L47K 47 L K 0.05 Neutral PMS2 P54278 L47M 47 L M 0.444 Neutral PMS2 P54278 L47N 47 L N 0.116 Neutral PMS2 P54278 L47P 47 L P 0.9 Pathogenic PMS2 P54278 L47Q 47 L Q 0.224 Neutral PMS2 P54278 L47R 47 L R 0.552 Pathogenic PMS2 P54278 L47S 47 L S 0.052 Neutral PMS2 P54278 L47T 47 L T 0.044 Neutral PMS2 P54278 L47V 47 L V 0.012 Neutral PMS2 P54278 L47W 47 L W 0.868 Pathogenic PMS2 P54278 L47Y 47 L Y 0.77 Pathogenic PMS2 P54278 P470A 470 P A 0.052 Neutral PMS2 P54278 P470C 470 P C 0.148 Neutral PMS2 P54278 P470D 470 P D 0.078 Neutral PMS2 P54278 P470E 470 P E 0.052 Neutral PMS2 P54278 P470F 470 P F 0.268 Neutral PMS2 P54278 P470G 470 P G 0.07 Neutral PMS2 P54278 P470H 470 P H 0.266 Neutral PMS2 P54278 P470I 470 P I 0.1 Neutral PMS2 P54278 P470K 470 P K 0.206 Neutral PMS2 P54278 P470L 470 P L 0.056 Neutral PMS2 P54278 P470M 470 P M 0.22 Neutral PMS2 P54278 P470N 470 P N 0.068 Neutral PMS2 P54278 P470Q 470 P Q 0.212 Neutral PMS2 P54278 P470R 470 P R 0.204 Neutral PMS2 P54278 P470S 470 P S 0.002 Neutral 1 PMS2 P54278 P470T 470 P T 0.034 Neutral PMS2 P54278 P470V 470 P V 0.184 Neutral PMS2 P54278 P470W 470 P W 0.39 Neutral PMS2 P54278 P470Y 470 P Y 0.32 Neutral PMS2 P54278 Q471A 471 Q A 0.08 Neutral PMS2 P54278 Q471C 471 Q C 0.064 Neutral PMS2 P54278 Q471D 471 Q D 0.006 Neutral PMS2 P54278 Q471E 471 Q E 0.084 Neutral PMS2 P54278 Q471F 471 Q F 0.26 Neutral PMS2 P54278 Q471G 471 Q G 0.03 Neutral PMS2 P54278 Q471H 471 Q H 0.034 Neutral PMS2 P54278 Q471I 471 Q I 0.278 Neutral PMS2 P54278 Q471K 471 Q K 0.02 Neutral PMS2 P54278 Q471L 471 Q L 0.242 Neutral PMS2 P54278 Q471M 471 Q M 0.186 Neutral PMS2 P54278 Q471N 471 Q N 0.026 Neutral PMS2 P54278 Q471P 471 Q P 0.368 Neutral PMS2 P54278 Q471R 471 Q R 0.002 Neutral PMS2 P54278 Q471S 471 Q S 0.184 Neutral PMS2 P54278 Q471T 471 Q T 0.014 Neutral PMS2 P54278 Q471V 471 Q V 0.26 Neutral PMS2 P54278 Q471W 471 Q W 0.432 Neutral PMS2 P54278 Q471Y 471 Q Y 0.362 Neutral PMS2 P54278 K472A 472 K A 0.056 Neutral PMS2 P54278 K472C 472 K C 0 Neutral PMS2 P54278 K472D 472 K D 0.002 Neutral PMS2 P54278 K472E 472 K E 0.004 Neutral PMS2 P54278 K472F 472 K F 0.114 Neutral PMS2 P54278 K472G 472 K G 0.044 Neutral PMS2 P54278 K472H 472 K H 0.048 Neutral PMS2 P54278 K472I 472 K I 0.19 Neutral PMS2 P54278 K472L 472 K L 0.214 Neutral PMS2 P54278 K472M 472 K M 0.106 Neutral PMS2 P54278 K472N 472 K N 0.05 Neutral PMS2 P54278 K472P 472 K P 0.01 Neutral PMS2 P54278 K472Q 472 K Q 0.024 Neutral PMS2 P54278 K472R 472 K R 0.016 Neutral PMS2 P54278 K472S 472 K S 0.014 Neutral PMS2 P54278 K472T 472 K T 0.18 Neutral PMS2 P54278 K472V 472 K V 0.12 Neutral PMS2 P54278 K472W 472 K W 0.268 Neutral PMS2 P54278 K472Y 472 K Y 0.326 Neutral PMS2 P54278 E473A 473 E A 0.066 Neutral PMS2 P54278 E473C 473 E C 0.09 Neutral PMS2 P54278 E473D 473 E D 0.004 Neutral PMS2 P54278 E473F 473 E F 0.092 Neutral PMS2 P54278 E473G 473 E G 0 Neutral PMS2 P54278 E473H 473 E H 0.016 Neutral PMS2 P54278 E473I 473 E I 0.322 Neutral PMS2 P54278 E473K 473 E K 0.002 Neutral PMS2 P54278 E473L 473 E L 0.286 Neutral PMS2 P54278 E473M 473 E M 0.164 Neutral PMS2 P54278 E473N 473 E N 0.036 Neutral PMS2 P54278 E473P 473 E P 0.3 Neutral PMS2 P54278 E473Q 473 E Q 0.018 Neutral PMS2 P54278 E473R 473 E R 0.01 Neutral PMS2 P54278 E473S 473 E S 0.014 Neutral PMS2 P54278 E473T 473 E T 0.08 Neutral PMS2 P54278 E473V 473 E V 0.066 Neutral PMS2 P54278 E473W 473 E W 0.43 Neutral PMS2 P54278 E473Y 473 E Y 0.338 Neutral PMS2 P54278 A474C 474 A C 0.182 Neutral PMS2 P54278 A474D 474 A D 0.33 Neutral PMS2 P54278 A474E 474 A E 0.274 Neutral PMS2 P54278 A474F 474 A F 0.468 Neutral PMS2 P54278 A474G 474 A G 0.004 Neutral PMS2 P54278 A474H 474 A H 0.26 Neutral PMS2 P54278 A474I 474 A I 0.396 Neutral PMS2 P54278 A474K 474 A K 0.262 Neutral PMS2 P54278 A474L 474 A L 0.32 Neutral PMS2 P54278 A474M 474 A M 0.266 Neutral PMS2 P54278 A474N 474 A N 0.296 Neutral PMS2 P54278 A474P 474 A P 0.138 Neutral PMS2 P54278 A474Q 474 A Q 0.248 Neutral PMS2 P54278 A474R 474 A R 0.318 Neutral PMS2 P54278 A474S 474 A S 0.156 Neutral PMS2 P54278 A474T 474 A T 0.08 Neutral PMS2 P54278 A474V 474 A V 0.042 Neutral PMS2 P54278 A474W 474 A W 0.504 Pathogenic PMS2 P54278 A474Y 474 A Y 0.5 Pathogenic PMS2 P54278 V475A 475 V A 0 Neutral PMS2 P54278 V475C 475 V C 0.038 Neutral PMS2 P54278 V475D 475 V D 0.126 Neutral PMS2 P54278 V475E 475 V E 0.098 Neutral PMS2 P54278 V475F 475 V F 0.15 Neutral PMS2 P54278 V475G 475 V G 0.196 Neutral PMS2 P54278 V475H 475 V H 0.068 Neutral PMS2 P54278 V475I 475 V I 0.008 Neutral PMS2 P54278 V475K 475 V K 0.138 Neutral PMS2 P54278 V475L 475 V L 0 Neutral PMS2 P54278 V475M 475 V M 0.014 Neutral PMS2 P54278 V475N 475 V N 0.144 Neutral PMS2 P54278 V475P 475 V P 0.038 Neutral PMS2 P54278 V475Q 475 V Q 0.216 Neutral PMS2 P54278 V475R 475 V R 0.208 Neutral PMS2 P54278 V475S 475 V S 0.024 Neutral PMS2 P54278 V475T 475 V T 0.008 Neutral PMS2 P54278 V475W 475 V W 0.344 Neutral PMS2 P54278 V475Y 475 V Y 0.256 Neutral PMS2 P54278 S476A 476 S A 0.068 Neutral PMS2 P54278 S476C 476 S C 0.008 Neutral PMS2 P54278 S476D 476 S D 0.002 Neutral PMS2 P54278 S476E 476 S E 0.124 Neutral PMS2 P54278 S476F 476 S F 0.276 Neutral PMS2 P54278 S476G 476 S G 0 Neutral PMS2 P54278 S476H 476 S H 0.172 Neutral PMS2 P54278 S476I 476 S I 0.124 Neutral PMS2 P54278 S476K 476 S K 0.15 Neutral PMS2 P54278 S476L 476 S L 0.028 Neutral PMS2 P54278 S476M 476 S M 0.332 Neutral PMS2 P54278 S476N 476 S N 0.018 Neutral PMS2 P54278 S476P 476 S P 0.062 Neutral PMS2 P54278 S476Q 476 S Q 0.132 Neutral PMS2 P54278 S476R 476 S R 0.138 Neutral PMS2 P54278 S476T 476 S T 0.02 Neutral PMS2 P54278 S476V 476 S V 0.288 Neutral PMS2 P54278 S476W 476 S W 0.49 Neutral PMS2 P54278 S476Y 476 S Y 0.448 Neutral PMS2 P54278 S477A 477 S A 0.068 Neutral PMS2 P54278 S477C 477 S C 0.032 Neutral PMS2 P54278 S477D 477 S D 0.026 Neutral PMS2 P54278 S477E 477 S E 0.152 Neutral PMS2 P54278 S477F 477 S F 0.28 Neutral PMS2 P54278 S477G 477 S G 0 Neutral PMS2 P54278 S477H 477 S H 0.242 Neutral PMS2 P54278 S477I 477 S I 0.026 Neutral PMS2 P54278 S477K 477 S K 0.146 Neutral PMS2 P54278 S477L 477 S L 0.032 Neutral PMS2 P54278 S477M 477 S M 0.35 Neutral PMS2 P54278 S477N 477 S N 0.034 Neutral PMS2 P54278 S477P 477 S P 0.056 Neutral PMS2 P54278 S477Q 477 S Q 0.162 Neutral PMS2 P54278 S477R 477 S R 0.154 Neutral PMS2 P54278 S477T 477 S T 0.178 Neutral PMS2 P54278 S477V 477 S V 0.298 Neutral PMS2 P54278 S477W 477 S W 0.502 Pathogenic PMS2 P54278 S477Y 477 S Y 0.458 Neutral PMS2 P54278 S478A 478 S A 0.01 Neutral PMS2 P54278 S478C 478 S C 0.032 Neutral PMS2 P54278 S478D 478 S D 0.004 Neutral PMS2 P54278 S478E 478 S E 0.124 Neutral PMS2 P54278 S478F 478 S F 0.276 Neutral PMS2 P54278 S478G 478 S G 0 Neutral PMS2 P54278 S478H 478 S H 0.17 Neutral PMS2 P54278 S478I 478 S I 0.124 Neutral PMS2 P54278 S478K 478 S K 0.162 Neutral PMS2 P54278 S478L 478 S L 0.028 Neutral PMS2 P54278 S478M 478 S M 0.332 Neutral PMS2 P54278 S478N 478 S N 0 Neutral PMS2 P54278 S478P 478 S P 0.116 Neutral PMS2 P54278 S478Q 478 S Q 0.132 Neutral PMS2 P54278 S478R 478 S R 0.136 Neutral PMS2 P54278 S478T 478 S T 0.024 Neutral PMS2 P54278 S478V 478 S V 0.034 Neutral PMS2 P54278 S478W 478 S W 0.49 Neutral PMS2 P54278 S478Y 478 S Y 0.448 Neutral PMS2 P54278 H479A 479 H A 0.062 Neutral PMS2 P54278 H479C 479 H C 0.042 Neutral PMS2 P54278 H479D 479 H D 0.006 Neutral PMS2 P54278 H479E 479 H E 0 Neutral PMS2 P54278 H479F 479 H F 0.204 Neutral PMS2 P54278 H479G 479 H G 0.042 Neutral PMS2 P54278 H479I 479 H I 0.258 Neutral PMS2 P54278 H479K 479 H K 0.004 Neutral PMS2 P54278 H479L 479 H L 0.104 Neutral PMS2 P54278 H479M 479 H M 0.014 Neutral PMS2 P54278 H479N 479 H N 0.058 Neutral PMS2 P54278 H479P 479 H P 0.026 Neutral PMS2 P54278 H479Q 479 H Q 0.006 Neutral PMS2 P54278 H479R 479 H R 0 Neutral PMS2 P54278 H479S 479 H S 0.218 Neutral PMS2 P54278 H479T 479 H T 0.006 Neutral PMS2 P54278 H479V 479 H V 0.064 Neutral PMS2 P54278 H479W 479 H W 0.398 Neutral PMS2 P54278 H479Y 479 H Y 0.306 Neutral PMS2 P54278 D48A 48 D A 0.778 Pathogenic PMS2 P54278 D48C 48 D C 0.91 Pathogenic PMS2 P54278 D48E 48 D E 0.946 Pathogenic PMS2 P54278 D48F 48 D F 0.986 Pathogenic PMS2 P54278 D48G 48 D G 0.936 Pathogenic PMS2 P54278 D48H 48 D H 0.636 Pathogenic PMS2 P54278 D48I 48 D I 0.972 Pathogenic PMS2 P54278 D48K 48 D K 0.438 Neutral PMS2 P54278 D48L 48 D L 0.978 Pathogenic PMS2 P54278 D48M 48 D M 0.962 Pathogenic PMS2 P54278 D48N 48 D N 0.842 Pathogenic PMS2 P54278 D48P 48 D P 0.904 Pathogenic PMS2 P54278 D48Q 48 D Q 0.366 Neutral PMS2 P54278 D48R 48 D R 0.558 Pathogenic PMS2 P54278 D48S 48 D S 0.686 Pathogenic PMS2 P54278 D48T 48 D T 0.838 Pathogenic PMS2 P54278 D48V 48 D V 0.992 Pathogenic PMS2 P54278 D48W 48 D W 0.984 Pathogenic PMS2 P54278 D48Y 48 D Y 0.978 Pathogenic PMS2 P54278 G480A 480 G A 0.01 Neutral PMS2 P54278 G480C 480 G C 0.162 Neutral PMS2 P54278 G480D 480 G D 0.118 Neutral PMS2 P54278 G480E 480 G E 0.166 Neutral PMS2 P54278 G480F 480 G F 0.478 Neutral PMS2 P54278 G480H 480 G H 0.294 Neutral PMS2 P54278 G480I 480 G I 0.412 Neutral PMS2 P54278 G480K 480 G K 0.416 Neutral PMS2 P54278 G480L 480 G L 0.412 Neutral PMS2 P54278 G480M 480 G M 0.34 Neutral PMS2 P54278 G480N 480 G N 0.252 Neutral PMS2 P54278 G480P 480 G P 0.35 Neutral PMS2 P54278 G480Q 480 G Q 0.262 Neutral PMS2 P54278 G480R 480 G R 0.292 Neutral PMS2 P54278 G480S 480 G S 0.018 Neutral PMS2 P54278 G480T 480 G T 0.272 Neutral PMS2 P54278 G480V 480 G V 0.304 Neutral PMS2 P54278 G480W 480 G W 0.488 Neutral PMS2 P54278 G480Y 480 G Y 0.424 Neutral PMS2 P54278 P481A 481 P A 0.034 Neutral PMS2 P54278 P481C 481 P C 0.148 Neutral PMS2 P54278 P481D 481 P D 0.05 Neutral PMS2 P54278 P481E 481 P E 0.052 Neutral PMS2 P54278 P481F 481 P F 0.272 Neutral PMS2 P54278 P481G 481 P G 0.07 Neutral PMS2 P54278 P481H 481 P H 0.266 Neutral PMS2 P54278 P481I 481 P I 0.088 Neutral PMS2 P54278 P481K 481 P K 0.206 Neutral PMS2 P54278 P481L 481 P L 0.096 Neutral PMS2 P54278 P481M 481 P M 0.22 Neutral PMS2 P54278 P481N 481 P N 0.068 Neutral PMS2 P54278 P481Q 481 P Q 0.15 Neutral PMS2 P54278 P481R 481 P R 0.204 Neutral PMS2 P54278 P481S 481 P S 0.002 Neutral PMS2 P54278 P481T 481 P T 0.084 Neutral PMS2 P54278 P481V 481 P V 0.184 Neutral PMS2 P54278 P481W 481 P W 0.39 Neutral PMS2 P54278 P481Y 481 P Y 0.32 Neutral PMS2 P54278 S482A 482 S A 0.068 Neutral PMS2 P54278 S482C 482 S C 0.002 Neutral PMS2 P54278 S482D 482 S D 0.002 Neutral PMS2 P54278 S482E 482 S E 0.114 Neutral PMS2 P54278 S482F 482 S F 0.276 Neutral PMS2 P54278 S482G 482 S G 0 Neutral PMS2 P54278 S482H 482 S H 0.17 Neutral PMS2 P54278 S482I 482 S I 0.196 Neutral PMS2 P54278 S482K 482 S K 0.14 Neutral PMS2 P54278 S482L 482 S L 0.062 Neutral PMS2 P54278 S482M 482 S M 0.28 Neutral PMS2 P54278 S482N 482 S N 0.034 Neutral PMS2 P54278 S482P 482 S P 0.062 Neutral PMS2 P54278 S482Q 482 S Q 0.158 Neutral PMS2 P54278 S482R 482 S R 0.154 Neutral PMS2 P54278 S482T 482 S T 0.11 Neutral PMS2 P54278 S482V 482 S V 0.032 Neutral PMS2 P54278 S482W 482 S W 0.49 Neutral PMS2 P54278 S482Y 482 S Y 0.448 Neutral PMS2 P54278 D483A 483 D A 0.1 Neutral PMS2 P54278 D483C 483 D C 0.148 Neutral PMS2 P54278 D483E 483 D E 0.162 Neutral PMS2 P54278 D483F 483 D F 0.37 Neutral PMS2 P54278 D483G 483 D G 0.036 Neutral PMS2 P54278 D483H 483 D H 0.09 Neutral PMS2 P54278 D483I 483 D I 0.214 Neutral PMS2 P54278 D483K 483 D K 0.02 Neutral PMS2 P54278 D483L 483 D L 0.108 Neutral PMS2 P54278 D483M 483 D M 0.19 Neutral PMS2 P54278 D483N 483 D N 0.012 Neutral PMS2 P54278 D483P 483 D P 0.036 Neutral PMS2 P54278 D483Q 483 D Q 0.112 Neutral PMS2 P54278 D483R 483 D R 0.15 Neutral PMS2 P54278 D483S 483 D S 0.002 Neutral PMS2 P54278 D483T 483 D T 0.012 Neutral PMS2 P54278 D483V 483 D V 0.262 Neutral PMS2 P54278 D483W 483 D W 0.434 Neutral PMS2 P54278 D483Y 483 D Y 0.404 Neutral PMS2 P54278 P484A 484 P A 0.176 Neutral PMS2 P54278 P484C 484 P C 0.03 Neutral PMS2 P54278 P484D 484 P D 0.028 Neutral PMS2 P54278 P484E 484 P E 0.166 Neutral PMS2 P54278 P484F 484 P F 0.272 Neutral PMS2 P54278 P484G 484 P G 0.01 Neutral PMS2 P54278 P484H 484 P H 0.232 Neutral PMS2 P54278 P484I 484 P I 0.088 Neutral PMS2 P54278 P484K 484 P K 0.144 Neutral PMS2 P54278 P484L 484 P L 0.048 Neutral PMS2 P54278 P484M 484 P M 0.22 Neutral PMS2 P54278 P484N 484 P N 0.008 Neutral PMS2 P54278 P484Q 484 P Q 0.096 Neutral PMS2 P54278 P484R 484 P R 0.222 Neutral PMS2 P54278 P484S 484 P S 0.002 Neutral PMS2 P54278 P484T 484 P T 0.034 Neutral PMS2 P54278 P484V 484 P V 0.14 Neutral PMS2 P54278 P484W 484 P W 0.39 Neutral PMS2 P54278 P484Y 484 P Y 0.32 Neutral PMS2 P54278 T485A 485 T A 0.078 Neutral PMS2 P54278 T485C 485 T C 0.064 Neutral PMS2 P54278 T485D 485 T D 0.024 Neutral PMS2 P54278 T485E 485 T E 0.05 Neutral PMS2 P54278 T485F 485 T F 0.214 Neutral PMS2 P54278 T485G 485 T G 0.036 Neutral PMS2 P54278 T485H 485 T H 0.084 Neutral PMS2 P54278 T485I 485 T I 0.066 Neutral PMS2 P54278 T485K 485 T K 0.002 Neutral 1 PMS2 P54278 T485L 485 T L 0.044 Neutral PMS2 P54278 T485M 485 T M 0.026 Neutral PMS2 P54278 T485N 485 T N 0.012 Neutral PMS2 P54278 T485P 485 T P 0.056 Neutral PMS2 P54278 T485Q 485 T Q 0.002 Neutral PMS2 P54278 T485R 485 T R 0.156 Neutral PMS2 P54278 T485S 485 T S 0 Neutral PMS2 P54278 T485V 485 T V 0.016 Neutral PMS2 P54278 T485W 485 T W 0.466 Neutral PMS2 P54278 T485Y 485 T Y 0.424 Neutral PMS2 P54278 D486A 486 D A 0.072 Neutral PMS2 P54278 D486C 486 D C 0.028 Neutral PMS2 P54278 D486E 486 D E 0.014 Neutral PMS2 P54278 D486F 486 D F 0.37 Neutral PMS2 P54278 D486G 486 D G 0.018 Neutral PMS2 P54278 D486H 486 D H 0.106 Neutral PMS2 P54278 D486I 486 D I 0.214 Neutral PMS2 P54278 D486K 486 D K 0.112 Neutral PMS2 P54278 D486L 486 D L 0.256 Neutral PMS2 P54278 D486M 486 D M 0.19 Neutral PMS2 P54278 D486N 486 D N 0 Neutral PMS2 P54278 D486P 486 D P 0.31 Neutral PMS2 P54278 D486Q 486 D Q 0.032 Neutral PMS2 P54278 D486R 486 D R 0.166 Neutral PMS2 P54278 D486S 486 D S 0.012 Neutral PMS2 P54278 D486T 486 D T 0.1 Neutral PMS2 P54278 D486V 486 D V 0.062 Neutral PMS2 P54278 D486W 486 D W 0.434 Neutral PMS2 P54278 D486Y 486 D Y 0.354 Neutral PMS2 P54278 R487A 487 R A 0.08 Neutral PMS2 P54278 R487C 487 R C 0.14 Neutral PMS2 P54278 R487D 487 R D 0.18 Neutral PMS2 P54278 R487E 487 R E 0.086 Neutral PMS2 P54278 R487F 487 R F 0.27 Neutral PMS2 P54278 R487G 487 R G 0.002 Neutral PMS2 P54278 R487H 487 R H 0.12 Neutral PMS2 P54278 R487I 487 R I 0.304 Neutral PMS2 P54278 R487K 487 R K 0.004 Neutral PMS2 P54278 R487L 487 R L 0.012 Neutral PMS2 P54278 R487M 487 R M 0.15 Neutral PMS2 P54278 R487N 487 R N 0.176 Neutral PMS2 P54278 R487P 487 R P 0.028 Neutral PMS2 P54278 R487Q 487 R Q 0.16 Neutral PMS2 P54278 R487S 487 R S 0.016 Neutral PMS2 P54278 R487T 487 R T 0.022 Neutral PMS2 P54278 R487V 487 R V 0.242 Neutral PMS2 P54278 R487W 487 R W 0.384 Neutral PMS2 P54278 R487Y 487 R Y 0.342 Neutral PMS2 P54278 A488C 488 A C 0.182 Neutral PMS2 P54278 A488D 488 A D 0.33 Neutral PMS2 P54278 A488E 488 A E 0.274 Neutral PMS2 P54278 A488F 488 A F 0.468 Neutral PMS2 P54278 A488G 488 A G 0.006 Neutral PMS2 P54278 A488H 488 A H 0.304 Neutral PMS2 P54278 A488I 488 A I 0.406 Neutral PMS2 P54278 A488K 488 A K 0.32 Neutral PMS2 P54278 A488L 488 A L 0.354 Neutral PMS2 P54278 A488M 488 A M 0.256 Neutral PMS2 P54278 A488N 488 A N 0.274 Neutral PMS2 P54278 A488P 488 A P 0.3 Neutral PMS2 P54278 A488Q 488 A Q 0.302 Neutral PMS2 P54278 A488R 488 A R 0.326 Neutral PMS2 P54278 A488S 488 A S 0.156 Neutral PMS2 P54278 A488T 488 A T 0.172 Neutral PMS2 P54278 A488V 488 A V 0.038 Neutral PMS2 P54278 A488W 488 A W 0.504 Pathogenic PMS2 P54278 A488Y 488 A Y 0.482 Neutral PMS2 P54278 E489A 489 E A 0.144 Neutral PMS2 P54278 E489C 489 E C 0.068 Neutral PMS2 P54278 E489D 489 E D 0 Neutral PMS2 P54278 E489F 489 E F 0.272 Neutral PMS2 P54278 E489G 489 E G 0.084 Neutral PMS2 P54278 E489H 489 E H 0.104 Neutral PMS2 P54278 E489I 489 E I 0.284 Neutral PMS2 P54278 E489K 489 E K 0.002 Neutral PMS2 P54278 E489L 489 E L 0.138 Neutral PMS2 P54278 E489M 489 E M 0.164 Neutral PMS2 P54278 E489N 489 E N 0.04 Neutral PMS2 P54278 E489P 489 E P 0.3 Neutral PMS2 P54278 E489Q 489 E Q 0.012 Neutral PMS2 P54278 E489R 489 E R 0.03 Neutral PMS2 P54278 E489S 489 E S 0.018 Neutral PMS2 P54278 E489T 489 E T 0.14 Neutral PMS2 P54278 E489V 489 E V 0.25 Neutral PMS2 P54278 E489W 489 E W 0.43 Neutral PMS2 P54278 E489Y 489 E Y 0.338 Neutral PMS2 P54278 A49C 49 A C 0.948 Pathogenic PMS2 P54278 A49D 49 A D 0.656 Pathogenic PMS2 P54278 A49E 49 A E 0.592 Pathogenic PMS2 P54278 A49F 49 A F 0.99 Pathogenic PMS2 P54278 A49G 49 A G 0.126 Neutral PMS2 P54278 A49H 49 A H 0.798 Pathogenic PMS2 P54278 A49I 49 A I 0.95 Pathogenic PMS2 P54278 A49K 49 A K 0.666 Pathogenic PMS2 P54278 A49L 49 A L 0.994 Pathogenic PMS2 P54278 A49M 49 A M 0.89 Pathogenic PMS2 P54278 A49N 49 A N 0.872 Pathogenic PMS2 P54278 A49P 49 A P 0.506 Pathogenic PMS2 P54278 A49Q 49 A Q 0.51 Pathogenic PMS2 P54278 A49R 49 A R 0.964 Pathogenic PMS2 P54278 A49S 49 A S 0.126 Neutral PMS2 P54278 A49T 49 A T 0.216 Neutral PMS2 P54278 A49V 49 A V 0.832 Pathogenic PMS2 P54278 A49W 49 A W 0.99 Pathogenic PMS2 P54278 A49Y 49 A Y 0.956 Pathogenic PMS2 P54278 V490A 490 V A 0 Neutral PMS2 P54278 V490C 490 V C 0.058 Neutral PMS2 P54278 V490D 490 V D 0.028 Neutral PMS2 P54278 V490E 490 V E 0.052 Neutral PMS2 P54278 V490F 490 V F 0.172 Neutral PMS2 P54278 V490G 490 V G 0.178 Neutral PMS2 P54278 V490H 490 V H 0.112 Neutral PMS2 P54278 V490I 490 V I 0.002 Neutral PMS2 P54278 V490K 490 V K 0.158 Neutral PMS2 P54278 V490L 490 V L 0.018 Neutral PMS2 P54278 V490M 490 V M 0.014 Neutral PMS2 P54278 V490N 490 V N 0.038 Neutral PMS2 P54278 V490P 490 V P 0.142 Neutral PMS2 P54278 V490Q 490 V Q 0.1 Neutral PMS2 P54278 V490R 490 V R 0.228 Neutral PMS2 P54278 V490S 490 V S 0.01 Neutral PMS2 P54278 V490T 490 V T 0.008 Neutral PMS2 P54278 V490W 490 V W 0.344 Neutral PMS2 P54278 V490Y 490 V Y 0.256 Neutral PMS2 P54278 E491A 491 E A 0.066 Neutral PMS2 P54278 E491C 491 E C 0.068 Neutral PMS2 P54278 E491D 491 E D 0 Neutral PMS2 P54278 E491F 491 E F 0.272 Neutral PMS2 P54278 E491G 491 E G 0 Neutral PMS2 P54278 E491H 491 E H 0.104 Neutral PMS2 P54278 E491I 491 E I 0.284 Neutral PMS2 P54278 E491K 491 E K 0.144 Neutral PMS2 P54278 E491L 491 E L 0.286 Neutral PMS2 P54278 E491M 491 E M 0.166 Neutral PMS2 P54278 E491N 491 E N 0.002 Neutral PMS2 P54278 E491P 491 E P 0.064 Neutral PMS2 P54278 E491Q 491 E Q 0.012 Neutral PMS2 P54278 E491R 491 E R 0.03 Neutral PMS2 P54278 E491S 491 E S 0.168 Neutral PMS2 P54278 E491T 491 E T 0.02 Neutral PMS2 P54278 E491V 491 E V 0.232 Neutral PMS2 P54278 E491W 491 E W 0.43 Neutral PMS2 P54278 E491Y 491 E Y 0.338 Neutral PMS2 P54278 K492A 492 K A 0.056 Neutral PMS2 P54278 K492C 492 K C 0.036 Neutral PMS2 P54278 K492D 492 K D 0.01 Neutral PMS2 P54278 K492E 492 K E 0.004 Neutral PMS2 P54278 K492F 492 K F 0.212 Neutral PMS2 P54278 K492G 492 K G 0.13 Neutral PMS2 P54278 K492H 492 K H 0.048 Neutral PMS2 P54278 K492I 492 K I 0.058 Neutral PMS2 P54278 K492L 492 K L 0.052 Neutral PMS2 P54278 K492M 492 K M 0.078 Neutral PMS2 P54278 K492N 492 K N 0.046 Neutral PMS2 P54278 K492P 492 K P 0.214 Neutral PMS2 P54278 K492Q 492 K Q 0.006 Neutral PMS2 P54278 K492R 492 K R 0.004 Neutral PMS2 P54278 K492S 492 K S 0.014 Neutral PMS2 P54278 K492T 492 K T 0.014 Neutral PMS2 P54278 K492V 492 K V 0.184 Neutral PMS2 P54278 K492W 492 K W 0.396 Neutral PMS2 P54278 K492Y 492 K Y 0.326 Neutral PMS2 P54278 D493A 493 D A 0.014 Neutral PMS2 P54278 D493C 493 D C 0.156 Neutral PMS2 P54278 D493E 493 D E 0.094 Neutral PMS2 P54278 D493F 493 D F 0.44 Neutral PMS2 P54278 D493G 493 D G 0.018 Neutral PMS2 P54278 D493H 493 D H 0.166 Neutral PMS2 P54278 D493I 493 D I 0.288 Neutral PMS2 P54278 D493K 493 D K 0.214 Neutral PMS2 P54278 D493L 493 D L 0.276 Neutral PMS2 P54278 D493M 493 D M 0.212 Neutral PMS2 P54278 D493N 493 D N 0.058 Neutral PMS2 P54278 D493P 493 D P 0.33 Neutral PMS2 P54278 D493Q 493 D Q 0.176 Neutral PMS2 P54278 D493R 493 D R 0.184 Neutral PMS2 P54278 D493S 493 D S 0.15 Neutral PMS2 P54278 D493T 493 D T 0.12 Neutral PMS2 P54278 D493V 493 D V 0.072 Neutral PMS2 P54278 D493W 493 D W 0.514 Pathogenic PMS2 P54278 D493Y 493 D Y 0.48 Neutral PMS2 P54278 S494A 494 S A 0.086 Neutral PMS2 P54278 S494C 494 S C 0.032 Neutral PMS2 P54278 S494D 494 S D 0.008 Neutral PMS2 P54278 S494E 494 S E 0.142 Neutral PMS2 P54278 S494F 494 S F 0.298 Neutral PMS2 P54278 S494G 494 S G 0.064 Neutral PMS2 P54278 S494H 494 S H 0.276 Neutral PMS2 P54278 S494I 494 S I 0.036 Neutral PMS2 P54278 S494K 494 S K 0.2 Neutral PMS2 P54278 S494L 494 S L 0.042 Neutral PMS2 P54278 S494M 494 S M 0.4 Neutral PMS2 P54278 S494N 494 S N 0.036 Neutral PMS2 P54278 S494P 494 S P 0.106 Neutral PMS2 P54278 S494Q 494 S Q 0.166 Neutral PMS2 P54278 S494R 494 S R 0.156 Neutral PMS2 P54278 S494T 494 S T 0.104 Neutral PMS2 P54278 S494V 494 S V 0.302 Neutral PMS2 P54278 S494W 494 S W 0.452 Neutral PMS2 P54278 S494Y 494 S Y 0.498 Neutral PMS2 P54278 G495A 495 G A 0.152 Neutral PMS2 P54278 G495C 495 G C 0.356 Neutral PMS2 P54278 G495D 495 G D 0.222 Neutral PMS2 P54278 G495E 495 G E 0.294 Neutral PMS2 P54278 G495F 495 G F 0.49 Neutral PMS2 P54278 G495H 495 G H 0.696 Pathogenic PMS2 P54278 G495I 495 G I 0.674 Pathogenic PMS2 P54278 G495K 495 G K 0.678 Pathogenic PMS2 P54278 G495L 495 G L 0.674 Pathogenic PMS2 P54278 G495M 495 G M 0.686 Pathogenic PMS2 P54278 G495N 495 G N 0.328 Neutral PMS2 P54278 G495P 495 G P 0.682 Pathogenic PMS2 P54278 G495Q 495 G Q 0.36 Neutral PMS2 P54278 G495R 495 G R 0.62 Pathogenic PMS2 P54278 G495S 495 G S 0.036 Neutral PMS2 P54278 G495T 495 G T 0.474 Neutral PMS2 P54278 G495V 495 G V 0.652 Pathogenic PMS2 P54278 G495W 495 G W 0.75 Pathogenic PMS2 P54278 G495Y 495 G Y 0.734 Pathogenic PMS2 P54278 H496A 496 H A 0.076 Neutral PMS2 P54278 H496C 496 H C 0 Neutral PMS2 P54278 H496D 496 H D 0.04 Neutral PMS2 P54278 H496E 496 H E 0.058 Neutral PMS2 P54278 H496F 496 H F 0.04 Neutral PMS2 P54278 H496G 496 H G 0.13 Neutral PMS2 P54278 H496I 496 H I 0.258 Neutral PMS2 P54278 H496K 496 H K 0.026 Neutral PMS2 P54278 H496L 496 H L 0.016 Neutral PMS2 P54278 H496M 496 H M 0.108 Neutral PMS2 P54278 H496N 496 H N 0.058 Neutral PMS2 P54278 H496P 496 H P 0.042 Neutral PMS2 P54278 H496Q 496 H Q 0.006 Neutral PMS2 P54278 H496R 496 H R 0.016 Neutral PMS2 P54278 H496S 496 H S 0.012 Neutral PMS2 P54278 H496T 496 H T 0.186 Neutral PMS2 P54278 H496V 496 H V 0.144 Neutral PMS2 P54278 H496W 496 H W 0.398 Neutral PMS2 P54278 H496Y 496 H Y 0.028 Neutral PMS2 P54278 G497A 497 G A 0.058 Neutral PMS2 P54278 G497C 497 G C 0.19 Neutral PMS2 P54278 G497D 497 G D 0.16 Neutral PMS2 P54278 G497E 497 G E 0.2 Neutral PMS2 P54278 G497F 497 G F 0.516 Pathogenic PMS2 P54278 G497H 497 G H 0.46 Neutral PMS2 P54278 G497I 497 G I 0.454 Neutral PMS2 P54278 G497K 497 G K 0.294 Neutral PMS2 P54278 G497L 497 G L 0.43 Neutral PMS2 P54278 G497M 497 G M 0.44 Neutral PMS2 P54278 G497N 497 G N 0.178 Neutral PMS2 P54278 G497P 497 G P 0.456 Neutral PMS2 P54278 G497Q 497 G Q 0.266 Neutral PMS2 P54278 G497R 497 G R 0.486 Neutral PMS2 P54278 G497S 497 G S 0.012 Neutral PMS2 P54278 G497T 497 G T 0.284 Neutral PMS2 P54278 G497V 497 G V 0.408 Neutral PMS2 P54278 G497W 497 G W 0.516 Pathogenic PMS2 P54278 G497Y 497 G Y 0.462 Neutral PMS2 P54278 S498A 498 S A 0.052 Neutral PMS2 P54278 S498C 498 S C 0.024 Neutral PMS2 P54278 S498D 498 S D 0.052 Neutral PMS2 P54278 S498E 498 S E 0.156 Neutral PMS2 P54278 S498F 498 S F 0.34 Neutral PMS2 P54278 S498G 498 S G 0 Neutral PMS2 P54278 S498H 498 S H 0.242 Neutral PMS2 P54278 S498I 498 S I 0.144 Neutral PMS2 P54278 S498K 498 S K 0.216 Neutral PMS2 P54278 S498L 498 S L 0.074 Neutral PMS2 P54278 S498M 498 S M 0.42 Neutral PMS2 P54278 S498N 498 S N 0.018 Neutral PMS2 P54278 S498P 498 S P 0.146 Neutral PMS2 P54278 S498Q 498 S Q 0.208 Neutral PMS2 P54278 S498R 498 S R 0.16 Neutral PMS2 P54278 S498T 498 S T 0.114 Neutral PMS2 P54278 S498V 498 S V 0.266 Neutral PMS2 P54278 S498W 498 S W 0.56 Pathogenic PMS2 P54278 S498Y 498 S Y 0.518 Pathogenic PMS2 P54278 T499A 499 T A 0 Neutral PMS2 P54278 T499C 499 T C 0.064 Neutral PMS2 P54278 T499D 499 T D 0.038 Neutral PMS2 P54278 T499E 499 T E 0.062 Neutral PMS2 P54278 T499F 499 T F 0.204 Neutral PMS2 P54278 T499G 499 T G 0.058 Neutral PMS2 P54278 T499H 499 T H 0.064 Neutral PMS2 P54278 T499I 499 T I 0.048 Neutral PMS2 P54278 T499K 499 T K 0.032 Neutral PMS2 P54278 T499L 499 T L 0.008 Neutral PMS2 P54278 T499M 499 T M 0.098 Neutral PMS2 P54278 T499N 499 T N 0.052 Neutral PMS2 P54278 T499P 499 T P 0.056 Neutral PMS2 P54278 T499Q 499 T Q 0.052 Neutral PMS2 P54278 T499R 499 T R 0.26 Neutral PMS2 P54278 T499S 499 T S 0 Neutral PMS2 P54278 T499V 499 T V 0.046 Neutral PMS2 P54278 T499W 499 T W 0.466 Neutral PMS2 P54278 T499Y 499 T Y 0.424 Neutral PMS2 P54278 E5A 5 E A 0.118 Neutral PMS2 P54278 E5C 5 E C 0.064 Neutral PMS2 P54278 E5D 5 E D 0.002 Neutral PMS2 P54278 E5F 5 E F 0.312 Neutral PMS2 P54278 E5G 5 E G 0 Neutral PMS2 P54278 E5H 5 E H 0.104 Neutral PMS2 P54278 E5I 5 E I 0.322 Neutral PMS2 P54278 E5K 5 E K 0.002 Neutral PMS2 P54278 E5L 5 E L 0.286 Neutral PMS2 P54278 E5M 5 E M 0.018 Neutral PMS2 P54278 E5N 5 E N 0.006 Neutral PMS2 P54278 E5P 5 E P 0.3 Neutral PMS2 P54278 E5Q 5 E Q 0 Neutral PMS2 P54278 E5R 5 E R 0.016 Neutral PMS2 P54278 E5S 5 E S 0.014 Neutral PMS2 P54278 E5T 5 E T 0.168 Neutral PMS2 P54278 E5V 5 E V 0.142 Neutral PMS2 P54278 E5W 5 E W 0.43 Neutral PMS2 P54278 E5Y 5 E Y 0.338 Neutral PMS2 P54278 G50A 50 G A 0.88 Pathogenic PMS2 P54278 G50C 50 G C 0.918 Pathogenic PMS2 P54278 G50D 50 G D 0.526 Pathogenic PMS2 P54278 G50E 50 G E 0.978 Pathogenic PMS2 P54278 G50F 50 G F 0.982 Pathogenic PMS2 P54278 G50H 50 G H 0.728 Pathogenic PMS2 P54278 G50I 50 G I 0.972 Pathogenic PMS2 P54278 G50K 50 G K 0.776 Pathogenic PMS2 P54278 G50L 50 G L 0.982 Pathogenic PMS2 P54278 G50M 50 G M 0.68 Pathogenic PMS2 P54278 G50N 50 G N 0.51 Pathogenic PMS2 P54278 G50P 50 G P 0.968 Pathogenic PMS2 P54278 G50Q 50 G Q 0.576 Pathogenic PMS2 P54278 G50R 50 G R 0.676 Pathogenic PMS2 P54278 G50S 50 G S 0.292 Neutral PMS2 P54278 G50T 50 G T 0.894 Pathogenic PMS2 P54278 G50V 50 G V 0.982 Pathogenic PMS2 P54278 G50W 50 G W 0.972 Pathogenic PMS2 P54278 G50Y 50 G Y 0.802 Pathogenic PMS2 P54278 S500A 500 S A 0.094 Neutral PMS2 P54278 S500C 500 S C 0.032 Neutral PMS2 P54278 S500D 500 S D 0.05 Neutral PMS2 P54278 S500E 500 S E 0.186 Neutral PMS2 P54278 S500F 500 S F 0.37 Neutral PMS2 P54278 S500G 500 S G 0.044 Neutral PMS2 P54278 S500H 500 S H 0.318 Neutral PMS2 P54278 S500I 500 S I 0.08 Neutral PMS2 P54278 S500K 500 S K 0.244 Neutral PMS2 P54278 S500L 500 S L 0.084 Neutral PMS2 P54278 S500M 500 S M 0.456 Neutral PMS2 P54278 S500N 500 S N 0.052 Neutral PMS2 P54278 S500P 500 S P 0.064 Neutral PMS2 P54278 S500Q 500 S Q 0.198 Neutral PMS2 P54278 S500R 500 S R 0.246 Neutral PMS2 P54278 S500T 500 S T 0.194 Neutral PMS2 P54278 S500V 500 S V 0.146 Neutral PMS2 P54278 S500W 500 S W 0.594 Pathogenic PMS2 P54278 S500Y 500 S Y 0.552 Pathogenic PMS2 P54278 V501A 501 V A 0 Neutral PMS2 P54278 V501C 501 V C 0.058 Neutral PMS2 P54278 V501D 501 V D 0.034 Neutral PMS2 P54278 V501E 501 V E 0.2 Neutral PMS2 P54278 V501F 501 V F 0.152 Neutral PMS2 P54278 V501G 501 V G 0.118 Neutral PMS2 P54278 V501H 501 V H 0.112 Neutral PMS2 P54278 V501I 501 V I 0.038 Neutral PMS2 P54278 V501K 501 V K 0.158 Neutral PMS2 P54278 V501L 501 V L 0.018 Neutral PMS2 P54278 V501M 501 V M 0.076 Neutral PMS2 P54278 V501N 501 V N 0.138 Neutral PMS2 P54278 V501P 501 V P 0.142 Neutral PMS2 P54278 V501Q 501 V Q 0.216 Neutral PMS2 P54278 V501R 501 V R 0.228 Neutral PMS2 P54278 V501S 501 V S 0.012 Neutral PMS2 P54278 V501T 501 V T 0.008 Neutral PMS2 P54278 V501W 501 V W 0.344 Neutral PMS2 P54278 V501Y 501 V Y 0.256 Neutral PMS2 P54278 D502A 502 D A 0.082 Neutral PMS2 P54278 D502C 502 D C 0.148 Neutral PMS2 P54278 D502E 502 D E 0.014 Neutral PMS2 P54278 D502F 502 D F 0.37 Neutral PMS2 P54278 D502G 502 D G 0.018 Neutral PMS2 P54278 D502H 502 D H 0.09 Neutral PMS2 P54278 D502I 502 D I 0.262 Neutral PMS2 P54278 D502K 502 D K 0.112 Neutral PMS2 P54278 D502L 502 D L 0.054 Neutral PMS2 P54278 D502M 502 D M 0.19 Neutral PMS2 P54278 D502N 502 D N 0.02 Neutral PMS2 P54278 D502P 502 D P 0.144 Neutral PMS2 P54278 D502Q 502 D Q 0.032 Neutral PMS2 P54278 D502R 502 D R 0.152 Neutral PMS2 P54278 D502S 502 D S 0.002 Neutral PMS2 P54278 D502T 502 D T 0.012 Neutral PMS2 P54278 D502V 502 D V 0.242 Neutral PMS2 P54278 D502W 502 D W 0.434 Neutral PMS2 P54278 D502Y 502 D Y 0.404 Neutral PMS2 P54278 S503A 503 S A 0.01 Neutral PMS2 P54278 S503C 503 S C 0.032 Neutral PMS2 P54278 S503D 503 S D 0.002 Neutral PMS2 P54278 S503E 503 S E 0.182 Neutral PMS2 P54278 S503F 503 S F 0.32 Neutral PMS2 P54278 S503G 503 S G 0.066 Neutral PMS2 P54278 S503H 503 S H 0.226 Neutral PMS2 P54278 S503I 503 S I 0.206 Neutral PMS2 P54278 S503K 503 S K 0.2 Neutral PMS2 P54278 S503L 503 S L 0.052 Neutral PMS2 P54278 S503M 503 S M 0.4 Neutral PMS2 P54278 S503N 503 S N 0.016 Neutral PMS2 P54278 S503P 503 S P 0.074 Neutral PMS2 P54278 S503Q 503 S Q 0.166 Neutral PMS2 P54278 S503R 503 S R 0.288 Neutral PMS2 P54278 S503T 503 S T 0.046 Neutral PMS2 P54278 S503V 503 S V 0.302 Neutral PMS2 P54278 S503W 503 S W 0.542 Pathogenic PMS2 P54278 S503Y 503 S Y 0.498 Neutral PMS2 P54278 E504A 504 E A 0.066 Neutral PMS2 P54278 E504C 504 E C 0.064 Neutral PMS2 P54278 E504D 504 E D 0 Neutral PMS2 P54278 E504F 504 E F 0.272 Neutral PMS2 P54278 E504G 504 E G 0.004 Neutral PMS2 P54278 E504H 504 E H 0.104 Neutral PMS2 P54278 E504I 504 E I 0.284 Neutral PMS2 P54278 E504K 504 E K 0.002 Neutral PMS2 P54278 E504L 504 E L 0.286 Neutral PMS2 P54278 E504M 504 E M 0.076 Neutral PMS2 P54278 E504N 504 E N 0.056 Neutral PMS2 P54278 E504P 504 E P 0.044 Neutral PMS2 P54278 E504Q 504 E Q 0.056 Neutral PMS2 P54278 E504R 504 E R 0.036 Neutral PMS2 P54278 E504S 504 E S 0.168 Neutral PMS2 P54278 E504T 504 E T 0.14 Neutral PMS2 P54278 E504V 504 E V 0.034 Neutral PMS2 P54278 E504W 504 E W 0.43 Neutral PMS2 P54278 E504Y 504 E Y 0.338 Neutral PMS2 P54278 G505A 505 G A 0.004 Neutral PMS2 P54278 G505C 505 G C 0.14 Neutral PMS2 P54278 G505D 505 G D 0.118 Neutral PMS2 P54278 G505E 505 G E 0.19 Neutral PMS2 P54278 G505F 505 G F 0.422 Neutral PMS2 P54278 G505H 505 G H 0.442 Neutral PMS2 P54278 G505I 505 G I 0.412 Neutral PMS2 P54278 G505K 505 G K 0.358 Neutral PMS2 P54278 G505L 505 G L 0.412 Neutral PMS2 P54278 G505M 505 G M 0.422 Neutral PMS2 P54278 G505N 505 G N 0.252 Neutral PMS2 P54278 G505P 505 G P 0.392 Neutral PMS2 P54278 G505Q 505 G Q 0.18 Neutral PMS2 P54278 G505R 505 G R 0.362 Neutral PMS2 P54278 G505S 505 G S 0.016 Neutral PMS2 P54278 G505T 505 G T 0.272 Neutral PMS2 P54278 G505V 505 G V 0.306 Neutral PMS2 P54278 G505W 505 G W 0.498 Neutral PMS2 P54278 G505Y 505 G Y 0.5 Pathogenic PMS2 P54278 F506A 506 F A 0.112 Neutral PMS2 P54278 F506C 506 F C 0.072 Neutral PMS2 P54278 F506D 506 F D 0.026 Neutral PMS2 P54278 F506E 506 F E 0.046 Neutral PMS2 P54278 F506G 506 F G 0.146 Neutral PMS2 P54278 F506H 506 F H 0.072 Neutral PMS2 P54278 F506I 506 F I 0.076 Neutral PMS2 P54278 F506K 506 F K 0.184 Neutral PMS2 P54278 F506L 506 F L 0.002 Neutral PMS2 P54278 F506M 506 F M 0.068 Neutral PMS2 P54278 F506N 506 F N 0.052 Neutral PMS2 P54278 F506P 506 F P 0.036 Neutral PMS2 P54278 F506Q 506 F Q 0.172 Neutral PMS2 P54278 F506R 506 F R 0.142 Neutral PMS2 P54278 F506S 506 F S 0.014 Neutral PMS2 P54278 F506T 506 F T 0.172 Neutral PMS2 P54278 F506V 506 F V 0.092 Neutral PMS2 P54278 F506W 506 F W 0.268 Neutral PMS2 P54278 F506Y 506 F Y 0.1 Neutral PMS2 P54278 S507A 507 S A 0.068 Neutral PMS2 P54278 S507C 507 S C 0.022 Neutral PMS2 P54278 S507D 507 S D 0.026 Neutral PMS2 P54278 S507E 507 S E 0.126 Neutral PMS2 P54278 S507F 507 S F 0.28 Neutral PMS2 P54278 S507G 507 S G 0 Neutral PMS2 P54278 S507H 507 S H 0.242 Neutral PMS2 P54278 S507I 507 S I 0.026 Neutral PMS2 P54278 S507K 507 S K 0.168 Neutral PMS2 P54278 S507L 507 S L 0.028 Neutral PMS2 P54278 S507M 507 S M 0.35 Neutral PMS2 P54278 S507N 507 S N 0.014 Neutral PMS2 P54278 S507P 507 S P 0.116 Neutral PMS2 P54278 S507Q 507 S Q 0.17 Neutral PMS2 P54278 S507R 507 S R 0.176 Neutral PMS2 P54278 S507T 507 S T 0.02 Neutral PMS2 P54278 S507V 507 S V 0.138 Neutral PMS2 P54278 S507W 507 S W 0.502 Pathogenic PMS2 P54278 S507Y 507 S Y 0.448 Neutral PMS2 P54278 I508A 508 I A 0.006 Neutral PMS2 P54278 I508C 508 I C 0.09 Neutral PMS2 P54278 I508D 508 I D 0.088 Neutral PMS2 P54278 I508E 508 I E 0.132 Neutral PMS2 P54278 I508F 508 I F 0.206 Neutral PMS2 P54278 I508G 508 I G 0.134 Neutral PMS2 P54278 I508H 508 I H 0.08 Neutral PMS2 P54278 I508K 508 I K 0.118 Neutral PMS2 P54278 I508L 508 I L 0.108 Neutral PMS2 P54278 I508M 508 I M 0.112 Neutral PMS2 P54278 I508N 508 I N 0.176 Neutral PMS2 P54278 I508P 508 I P 0.062 Neutral PMS2 P54278 I508Q 508 I Q 0.174 Neutral PMS2 P54278 I508R 508 I R 0.26 Neutral PMS2 P54278 I508S 508 I S 0.144 Neutral PMS2 P54278 I508T 508 I T 0.002 Neutral PMS2 P54278 I508V 508 I V 0.022 Neutral PMS2 P54278 I508W 508 I W 0.344 Neutral PMS2 P54278 I508Y 508 I Y 0.298 Neutral PMS2 P54278 P509A 509 P A 0.182 Neutral PMS2 P54278 P509C 509 P C 0.164 Neutral PMS2 P54278 P509D 509 P D 0.086 Neutral PMS2 P54278 P509E 509 P E 0.068 Neutral PMS2 P54278 P509F 509 P F 0.356 Neutral PMS2 P54278 P509G 509 P G 0.024 Neutral PMS2 P54278 P509H 509 P H 0.34 Neutral PMS2 P54278 P509I 509 P I 0.124 Neutral PMS2 P54278 P509K 509 P K 0.126 Neutral PMS2 P54278 P509L 509 P L 0.102 Neutral PMS2 P54278 P509M 509 P M 0.274 Neutral PMS2 P54278 P509N 509 P N 0.068 Neutral PMS2 P54278 P509Q 509 P Q 0.198 Neutral PMS2 P54278 P509R 509 P R 0.266 Neutral PMS2 P54278 P509S 509 P S 0.192 Neutral PMS2 P54278 P509T 509 P T 0.192 Neutral PMS2 P54278 P509V 509 P V 0.152 Neutral PMS2 P54278 P509W 509 P W 0.462 Neutral PMS2 P54278 P509Y 509 P Y 0.39 Neutral PMS2 P54278 A51C 51 A C 0.94 Pathogenic PMS2 P54278 A51D 51 A D 0.932 Pathogenic PMS2 P54278 A51E 51 A E 0.942 Pathogenic PMS2 P54278 A51F 51 A F 0.642 Pathogenic PMS2 P54278 A51G 51 A G 0.316 Neutral PMS2 P54278 A51H 51 A H 0.918 Pathogenic PMS2 P54278 A51I 51 A I 0.96 Pathogenic PMS2 P54278 A51K 51 A K 0.962 Pathogenic PMS2 P54278 A51L 51 A L 0.994 Pathogenic PMS2 P54278 A51M 51 A M 0.892 Pathogenic PMS2 P54278 A51N 51 A N 0.854 Pathogenic PMS2 P54278 A51P 51 A P 0.972 Pathogenic PMS2 P54278 A51Q 51 A Q 0.866 Pathogenic PMS2 P54278 A51R 51 A R 0.962 Pathogenic PMS2 P54278 A51S 51 A S 0.114 Neutral PMS2 P54278 A51T 51 A T 0.82 Pathogenic PMS2 P54278 A51V 51 A V 0.928 Pathogenic PMS2 P54278 A51W 51 A W 0.99 Pathogenic PMS2 P54278 A51Y 51 A Y 0.964 Pathogenic PMS2 P54278 D510A 510 D A 0.016 Neutral PMS2 P54278 D510C 510 D C 0.17 Neutral PMS2 P54278 D510E 510 D E 0.01 Neutral PMS2 P54278 D510F 510 D F 0.37 Neutral PMS2 P54278 D510G 510 D G 0.036 Neutral PMS2 P54278 D510H 510 D H 0.09 Neutral PMS2 P54278 D510I 510 D I 0.302 Neutral PMS2 P54278 D510K 510 D K 0.02 Neutral PMS2 P54278 D510L 510 D L 0.256 Neutral PMS2 P54278 D510M 510 D M 0.19 Neutral PMS2 P54278 D510N 510 D N 0.058 Neutral PMS2 P54278 D510P 510 D P 0.038 Neutral PMS2 P54278 D510Q 510 D Q 0.172 Neutral PMS2 P54278 D510R 510 D R 0.166 Neutral PMS2 P54278 D510S 510 D S 0.012 Neutral PMS2 P54278 D510T 510 D T 0.032 Neutral PMS2 P54278 D510V 510 D V 0.064 Neutral PMS2 P54278 D510W 510 D W 0.434 Neutral PMS2 P54278 D510Y 510 D Y 0.404 Neutral PMS2 P54278 T511A 511 T A 0 Neutral 1 PMS2 P54278 T511C 511 T C 0.064 Neutral PMS2 P54278 T511D 511 T D 0.046 Neutral PMS2 P54278 T511E 511 T E 0.024 Neutral PMS2 P54278 T511F 511 T F 0.204 Neutral PMS2 P54278 T511G 511 T G 0.002 Neutral PMS2 P54278 T511H 511 T H 0.084 Neutral PMS2 P54278 T511I 511 T I 0.096 Neutral PMS2 P54278 T511K 511 T K 0.026 Neutral PMS2 P54278 T511L 511 T L 0.074 Neutral PMS2 P54278 T511M 511 T M 0.026 Neutral 1 PMS2 P54278 T511N 511 T N 0.052 Neutral PMS2 P54278 T511P 511 T P 0.1 Neutral PMS2 P54278 T511Q 511 T Q 0.052 Neutral PMS2 P54278 T511R 511 T R 0.174 Neutral PMS2 P54278 T511S 511 T S 0 Neutral PMS2 P54278 T511V 511 T V 0.016 Neutral PMS2 P54278 T511W 511 T W 0.466 Neutral PMS2 P54278 T511Y 511 T Y 0.424 Neutral PMS2 P54278 G512A 512 G A 0.002 Neutral PMS2 P54278 G512C 512 G C 0.14 Neutral PMS2 P54278 G512D 512 G D 0.136 Neutral PMS2 P54278 G512E 512 G E 0.174 Neutral PMS2 P54278 G512F 512 G F 0.498 Neutral PMS2 P54278 G512H 512 G H 0.442 Neutral PMS2 P54278 G512I 512 G I 0.412 Neutral PMS2 P54278 G512K 512 G K 0.312 Neutral PMS2 P54278 G512L 512 G L 0.412 Neutral PMS2 P54278 G512M 512 G M 0.422 Neutral PMS2 P54278 G512N 512 G N 0.168 Neutral PMS2 P54278 G512P 512 G P 0.442 Neutral PMS2 P54278 G512Q 512 G Q 0.262 Neutral PMS2 P54278 G512R 512 G R 0.292 Neutral PMS2 P54278 G512S 512 G S 0.014 Neutral PMS2 P54278 G512T 512 G T 0.274 Neutral PMS2 P54278 G512V 512 G V 0.318 Neutral PMS2 P54278 G512W 512 G W 0.498 Neutral PMS2 P54278 G512Y 512 G Y 0.5 Pathogenic PMS2 P54278 S513A 513 S A 0.068 Neutral PMS2 P54278 S513C 513 S C 0.022 Neutral PMS2 P54278 S513D 513 S D 0.002 Neutral PMS2 P54278 S513E 513 S E 0.148 Neutral PMS2 P54278 S513F 513 S F 0.276 Neutral PMS2 P54278 S513G 513 S G 0.002 Neutral PMS2 P54278 S513H 513 S H 0.17 Neutral PMS2 P54278 S513I 513 S I 0.026 Neutral PMS2 P54278 S513K 513 S K 0.14 Neutral PMS2 P54278 S513L 513 S L 0.028 Neutral PMS2 P54278 S513M 513 S M 0.332 Neutral PMS2 P54278 S513N 513 S N 0.034 Neutral PMS2 P54278 S513P 513 S P 0.116 Neutral PMS2 P54278 S513Q 513 S Q 0.158 Neutral PMS2 P54278 S513R 513 S R 0.152 Neutral PMS2 P54278 S513T 513 S T 0.046 Neutral PMS2 P54278 S513V 513 S V 0.248 Neutral PMS2 P54278 S513W 513 S W 0.49 Neutral PMS2 P54278 S513Y 513 S Y 0.448 Neutral PMS2 P54278 H514A 514 H A 0.076 Neutral PMS2 P54278 H514C 514 H C 0 Neutral PMS2 P54278 H514D 514 H D 0.032 Neutral PMS2 P54278 H514E 514 H E 0.058 Neutral PMS2 P54278 H514F 514 H F 0.246 Neutral PMS2 P54278 H514G 514 H G 0.13 Neutral PMS2 P54278 H514I 514 H I 0.258 Neutral PMS2 P54278 H514K 514 H K 0.116 Neutral PMS2 P54278 H514L 514 H L 0.232 Neutral PMS2 P54278 H514M 514 H M 0.108 Neutral PMS2 P54278 H514N 514 H N 0.058 Neutral PMS2 P54278 H514P 514 H P 0.274 Neutral PMS2 P54278 H514Q 514 H Q 0.014 Neutral PMS2 P54278 H514R 514 H R 0 Neutral PMS2 P54278 H514S 514 H S 0.012 Neutral PMS2 P54278 H514T 514 H T 0.186 Neutral PMS2 P54278 H514V 514 H V 0.016 Neutral PMS2 P54278 H514W 514 H W 0.398 Neutral PMS2 P54278 H514Y 514 H Y 0.306 Neutral PMS2 P54278 C515A 515 C A 0.072 Neutral PMS2 P54278 C515D 515 C D 0.056 Neutral PMS2 P54278 C515E 515 C E 0.112 Neutral PMS2 P54278 C515F 515 C F 0.322 Neutral PMS2 P54278 C515G 515 C G 0.166 Neutral PMS2 P54278 C515H 515 C H 0.202 Neutral PMS2 P54278 C515I 515 C I 0.106 Neutral PMS2 P54278 C515K 515 C K 0.062 Neutral PMS2 P54278 C515L 515 C L 0.042 Neutral PMS2 P54278 C515M 515 C M 0.136 Neutral PMS2 P54278 C515N 515 C N 0.04 Neutral PMS2 P54278 C515P 515 C P 0.024 Neutral PMS2 P54278 C515Q 515 C Q 0.082 Neutral PMS2 P54278 C515R 515 C R 0.208 Neutral PMS2 P54278 C515S 515 C S 0.014 Neutral PMS2 P54278 C515T 515 C T 0.06 Neutral PMS2 P54278 C515V 515 C V 0.012 Neutral PMS2 P54278 C515W 515 C W 0.482 Neutral PMS2 P54278 C515Y 515 C Y 0.444 Neutral PMS2 P54278 S516A 516 S A 0.052 Neutral PMS2 P54278 S516C 516 S C 0.022 Neutral PMS2 P54278 S516D 516 S D 0.046 Neutral PMS2 P54278 S516E 516 S E 0.13 Neutral PMS2 P54278 S516F 516 S F 0.288 Neutral PMS2 P54278 S516G 516 S G 0 Neutral PMS2 P54278 S516H 516 S H 0.258 Neutral PMS2 P54278 S516I 516 S I 0.172 Neutral PMS2 P54278 S516K 516 S K 0.162 Neutral PMS2 P54278 S516L 516 S L 0.032 Neutral PMS2 P54278 S516M 516 S M 0.374 Neutral PMS2 P54278 S516N 516 S N 0 Neutral PMS2 P54278 S516P 516 S P 0.116 Neutral PMS2 P54278 S516Q 516 S Q 0.174 Neutral PMS2 P54278 S516R 516 S R 0.146 Neutral PMS2 P54278 S516T 516 S T 0.104 Neutral PMS2 P54278 S516V 516 S V 0.256 Neutral PMS2 P54278 S516W 516 S W 0.524 Pathogenic PMS2 P54278 S516Y 516 S Y 0.48 Neutral PMS2 P54278 S517A 517 S A 0.018 Neutral PMS2 P54278 S517C 517 S C 0.032 Neutral PMS2 P54278 S517D 517 S D 0.024 Neutral PMS2 P54278 S517E 517 S E 0.138 Neutral PMS2 P54278 S517F 517 S F 0.264 Neutral PMS2 P54278 S517G 517 S G 0.002 Neutral PMS2 P54278 S517H 517 S H 0.238 Neutral PMS2 P54278 S517I 517 S I 0.17 Neutral PMS2 P54278 S517K 517 S K 0.164 Neutral PMS2 P54278 S517L 517 S L 0.068 Neutral PMS2 P54278 S517M 517 S M 0.332 Neutral PMS2 P54278 S517N 517 S N 0 Neutral PMS2 P54278 S517P 517 S P 0.116 Neutral PMS2 P54278 S517Q 517 S Q 0.158 Neutral PMS2 P54278 S517R 517 S R 0.154 Neutral PMS2 P54278 S517T 517 S T 0.02 Neutral PMS2 P54278 S517V 517 S V 0.248 Neutral PMS2 P54278 S517W 517 S W 0.49 Neutral PMS2 P54278 S517Y 517 S Y 0.448 Neutral PMS2 P54278 E518A 518 E A 0.212 Neutral PMS2 P54278 E518C 518 E C 0.068 Neutral PMS2 P54278 E518D 518 E D 0 Neutral PMS2 P54278 E518F 518 E F 0.272 Neutral PMS2 P54278 E518G 518 E G 0 Neutral PMS2 P54278 E518H 518 E H 0.104 Neutral PMS2 P54278 E518I 518 E I 0.254 Neutral PMS2 P54278 E518K 518 E K 0.144 Neutral PMS2 P54278 E518L 518 E L 0.138 Neutral PMS2 P54278 E518M 518 E M 0.164 Neutral PMS2 P54278 E518N 518 E N 0.036 Neutral PMS2 P54278 E518P 518 E P 0.3 Neutral PMS2 P54278 E518Q 518 E Q 0.056 Neutral PMS2 P54278 E518R 518 E R 0.036 Neutral PMS2 P54278 E518S 518 E S 0.058 Neutral PMS2 P54278 E518T 518 E T 0.168 Neutral PMS2 P54278 E518V 518 E V 0.034 Neutral PMS2 P54278 E518W 518 E W 0.43 Neutral PMS2 P54278 E518Y 518 E Y 0.338 Neutral PMS2 P54278 Y519A 519 Y A 0.114 Neutral PMS2 P54278 Y519C 519 Y C 0.052 Neutral PMS2 P54278 Y519D 519 Y D 0.112 Neutral PMS2 P54278 Y519E 519 Y E 0.112 Neutral PMS2 P54278 Y519F 519 Y F 0.016 Neutral PMS2 P54278 Y519G 519 Y G 0.122 Neutral PMS2 P54278 Y519H 519 Y H 0.002 Neutral PMS2 P54278 Y519I 519 Y I 0.094 Neutral PMS2 P54278 Y519K 519 Y K 0.168 Neutral PMS2 P54278 Y519L 519 Y L 0.044 Neutral PMS2 P54278 Y519M 519 Y M 0.076 Neutral PMS2 P54278 Y519N 519 Y N 0.116 Neutral PMS2 P54278 Y519P 519 Y P 0.032 Neutral PMS2 P54278 Y519Q 519 Y Q 0.064 Neutral PMS2 P54278 Y519R 519 Y R 0.032 Neutral PMS2 P54278 Y519S 519 Y S 0.096 Neutral PMS2 P54278 Y519T 519 Y T 0.052 Neutral PMS2 P54278 Y519V 519 Y V 0.162 Neutral PMS2 P54278 Y519W 519 Y W 0.02 Neutral PMS2 P54278 T52A 52 T A 0.12 Neutral PMS2 P54278 T52C 52 T C 0.382 Neutral PMS2 P54278 T52D 52 T D 0.774 Pathogenic PMS2 P54278 T52E 52 T E 0.33 Neutral PMS2 P54278 T52F 52 T F 0.61 Pathogenic PMS2 P54278 T52G 52 T G 0.088 Neutral PMS2 P54278 T52H 52 T H 0.544 Pathogenic PMS2 P54278 T52I 52 T I 0.818 Pathogenic PMS2 P54278 T52K 52 T K 0.308 Neutral PMS2 P54278 T52L 52 T L 0.26 Neutral PMS2 P54278 T52M 52 T M 0.904 Pathogenic PMS2 P54278 T52N 52 T N 0.248 Neutral PMS2 P54278 T52P 52 T P 0.854 Pathogenic PMS2 P54278 T52Q 52 T Q 0.2 Neutral PMS2 P54278 T52R 52 T R 0.548 Pathogenic PMS2 P54278 T52S 52 T S 0.072 Neutral PMS2 P54278 T52V 52 T V 0.772 Pathogenic PMS2 P54278 T52W 52 T W 0.944 Pathogenic PMS2 P54278 T52Y 52 T Y 0.944 Pathogenic PMS2 P54278 A520C 520 A C 0.212 Neutral PMS2 P54278 A520D 520 A D 0.266 Neutral PMS2 P54278 A520E 520 A E 0.276 Neutral PMS2 P54278 A520F 520 A F 0.408 Neutral PMS2 P54278 A520G 520 A G 0.006 Neutral PMS2 P54278 A520H 520 A H 0.26 Neutral PMS2 P54278 A520I 520 A I 0.334 Neutral PMS2 P54278 A520K 520 A K 0.32 Neutral PMS2 P54278 A520L 520 A L 0.354 Neutral PMS2 P54278 A520M 520 A M 0.228 Neutral PMS2 P54278 A520N 520 A N 0.314 Neutral PMS2 P54278 A520P 520 A P 0.272 Neutral PMS2 P54278 A520Q 520 A Q 0.286 Neutral PMS2 P54278 A520R 520 A R 0.36 Neutral PMS2 P54278 A520S 520 A S 0.156 Neutral PMS2 P54278 A520T 520 A T 0.014 Neutral PMS2 P54278 A520V 520 A V 0.042 Neutral PMS2 P54278 A520W 520 A W 0.504 Pathogenic PMS2 P54278 A520Y 520 A Y 0.5 Pathogenic PMS2 P54278 A521C 521 A C 0.182 Neutral PMS2 P54278 A521D 521 A D 0.33 Neutral PMS2 P54278 A521E 521 A E 0.302 Neutral PMS2 P54278 A521F 521 A F 0.408 Neutral PMS2 P54278 A521G 521 A G 0.004 Neutral PMS2 P54278 A521H 521 A H 0.26 Neutral PMS2 P54278 A521I 521 A I 0.356 Neutral PMS2 P54278 A521K 521 A K 0.32 Neutral PMS2 P54278 A521L 521 A L 0.354 Neutral PMS2 P54278 A521M 521 A M 0.226 Neutral PMS2 P54278 A521N 521 A N 0.296 Neutral PMS2 P54278 A521P 521 A P 0.272 Neutral PMS2 P54278 A521Q 521 A Q 0.302 Neutral PMS2 P54278 A521R 521 A R 0.318 Neutral PMS2 P54278 A521S 521 A S 0.068 Neutral PMS2 P54278 A521T 521 A T 0.014 Neutral PMS2 P54278 A521V 521 A V 0.042 Neutral PMS2 P54278 A521W 521 A W 0.504 Pathogenic PMS2 P54278 A521Y 521 A Y 0.5 Pathogenic PMS2 P54278 S522A 522 S A 0.068 Neutral PMS2 P54278 S522C 522 S C 0.022 Neutral PMS2 P54278 S522D 522 S D 0.024 Neutral PMS2 P54278 S522E 522 S E 0.148 Neutral PMS2 P54278 S522F 522 S F 0.264 Neutral PMS2 P54278 S522G 522 S G 0.036 Neutral PMS2 P54278 S522H 522 S H 0.188 Neutral PMS2 P54278 S522I 522 S I 0.124 Neutral PMS2 P54278 S522K 522 S K 0.14 Neutral PMS2 P54278 S522L 522 S L 0.068 Neutral PMS2 P54278 S522M 522 S M 0.27 Neutral PMS2 P54278 S522N 522 S N 0 Neutral PMS2 P54278 S522P 522 S P 0.116 Neutral PMS2 P54278 S522Q 522 S Q 0.158 Neutral PMS2 P54278 S522R 522 S R 0.17 Neutral PMS2 P54278 S522T 522 S T 0.02 Neutral PMS2 P54278 S522V 522 S V 0.248 Neutral PMS2 P54278 S522W 522 S W 0.49 Neutral PMS2 P54278 S522Y 522 S Y 0.448 Neutral PMS2 P54278 S523A 523 S A 0.068 Neutral PMS2 P54278 S523C 523 S C 0.008 Neutral PMS2 P54278 S523D 523 S D 0.044 Neutral PMS2 P54278 S523E 523 S E 0.148 Neutral PMS2 P54278 S523F 523 S F 0.264 Neutral PMS2 P54278 S523G 523 S G 0.064 Neutral PMS2 P54278 S523H 523 S H 0.238 Neutral PMS2 P54278 S523I 523 S I 0.026 Neutral PMS2 P54278 S523K 523 S K 0.14 Neutral PMS2 P54278 S523L 523 S L 0.068 Neutral PMS2 P54278 S523M 523 S M 0.332 Neutral PMS2 P54278 S523N 523 S N 0.012 Neutral PMS2 P54278 S523P 523 S P 0.062 Neutral PMS2 P54278 S523Q 523 S Q 0.16 Neutral PMS2 P54278 S523R 523 S R 0.152 Neutral PMS2 P54278 S523T 523 S T 0.024 Neutral PMS2 P54278 S523V 523 S V 0.248 Neutral PMS2 P54278 S523W 523 S W 0.49 Neutral PMS2 P54278 S523Y 523 S Y 0.448 Neutral PMS2 P54278 P524A 524 P A 0.178 Neutral PMS2 P54278 P524C 524 P C 0.152 Neutral PMS2 P54278 P524D 524 P D 0.028 Neutral PMS2 P54278 P524E 524 P E 0.228 Neutral PMS2 P54278 P524F 524 P F 0.25 Neutral PMS2 P54278 P524G 524 P G 0.066 Neutral PMS2 P54278 P524H 524 P H 0.246 Neutral PMS2 P54278 P524I 524 P I 0.112 Neutral PMS2 P54278 P524K 524 P K 0.164 Neutral PMS2 P54278 P524L 524 P L 0.058 Neutral PMS2 P54278 P524M 524 P M 0.234 Neutral PMS2 P54278 P524N 524 P N 0.068 Neutral PMS2 P54278 P524Q 524 P Q 0.226 Neutral PMS2 P54278 P524R 524 P R 0.212 Neutral PMS2 P54278 P524S 524 P S 0.022 Neutral PMS2 P54278 P524T 524 P T 0.192 Neutral PMS2 P54278 P524V 524 P V 0.144 Neutral PMS2 P54278 P524W 524 P W 0.408 Neutral PMS2 P54278 P524Y 524 P Y 0.338 Neutral PMS2 P54278 G525A 525 G A 0.01 Neutral PMS2 P54278 G525C 525 G C 0.14 Neutral PMS2 P54278 G525D 525 G D 0.12 Neutral PMS2 P54278 G525E 525 G E 0.192 Neutral PMS2 P54278 G525F 525 G F 0.498 Neutral PMS2 P54278 G525H 525 G H 0.37 Neutral PMS2 P54278 G525I 525 G I 0.394 Neutral PMS2 P54278 G525K 525 G K 0.286 Neutral PMS2 P54278 G525L 525 G L 0.412 Neutral PMS2 P54278 G525M 525 G M 0.422 Neutral PMS2 P54278 G525N 525 G N 0.172 Neutral PMS2 P54278 G525P 525 G P 0.372 Neutral PMS2 P54278 G525Q 525 G Q 0.18 Neutral PMS2 P54278 G525R 525 G R 0.362 Neutral PMS2 P54278 G525S 525 G S 0.168 Neutral PMS2 P54278 G525T 525 G T 0.284 Neutral PMS2 P54278 G525V 525 G V 0.39 Neutral PMS2 P54278 G525W 525 G W 0.498 Neutral PMS2 P54278 G525Y 525 G Y 0.5 Pathogenic PMS2 P54278 D526A 526 D A 0.028 Neutral PMS2 P54278 D526C 526 D C 0.156 Neutral PMS2 P54278 D526E 526 D E 0.014 Neutral PMS2 P54278 D526F 526 D F 0.39 Neutral PMS2 P54278 D526G 526 D G 0.172 Neutral PMS2 P54278 D526H 526 D H 0.096 Neutral PMS2 P54278 D526I 526 D I 0.272 Neutral PMS2 P54278 D526K 526 D K 0.112 Neutral PMS2 P54278 D526L 526 D L 0.272 Neutral PMS2 P54278 D526M 526 D M 0.2 Neutral PMS2 P54278 D526N 526 D N 0 Neutral PMS2 P54278 D526P 526 D P 0.296 Neutral PMS2 P54278 D526Q 526 D Q 0.114 Neutral PMS2 P54278 D526R 526 D R 0.15 Neutral PMS2 P54278 D526S 526 D S 0.002 Neutral PMS2 P54278 D526T 526 D T 0.162 Neutral PMS2 P54278 D526V 526 D V 0.272 Neutral PMS2 P54278 D526W 526 D W 0.452 Neutral PMS2 P54278 D526Y 526 D Y 0.422 Neutral PMS2 P54278 R527A 527 R A 0.08 Neutral PMS2 P54278 R527C 527 R C 0.148 Neutral PMS2 P54278 R527D 527 R D 0.02 Neutral PMS2 P54278 R527E 527 R E 0.162 Neutral PMS2 P54278 R527F 527 R F 0.28 Neutral PMS2 P54278 R527G 527 R G 0.002 Neutral PMS2 P54278 R527H 527 R H 0.12 Neutral PMS2 P54278 R527I 527 R I 0.304 Neutral PMS2 P54278 R527K 527 R K 0.168 Neutral PMS2 P54278 R527L 527 R L 0.012 Neutral PMS2 P54278 R527M 527 R M 0.164 Neutral PMS2 P54278 R527N 527 R N 0.198 Neutral PMS2 P54278 R527P 527 R P 0.028 Neutral PMS2 P54278 R527Q 527 R Q 0.16 Neutral PMS2 P54278 R527S 527 R S 0.016 Neutral PMS2 P54278 R527T 527 R T 0.164 Neutral PMS2 P54278 R527V 527 R V 0.056 Neutral PMS2 P54278 R527W 527 R W 0.384 Neutral PMS2 P54278 R527Y 527 R Y 0.284 Neutral PMS2 P54278 G528A 528 G A 0.01 Neutral PMS2 P54278 G528C 528 G C 0.168 Neutral PMS2 P54278 G528D 528 G D 0.154 Neutral PMS2 P54278 G528E 528 G E 0.304 Neutral PMS2 P54278 G528F 528 G F 0.38 Neutral PMS2 P54278 G528H 528 G H 0.294 Neutral PMS2 P54278 G528I 528 G I 0.416 Neutral PMS2 P54278 G528K 528 G K 0.358 Neutral PMS2 P54278 G528L 528 G L 0.332 Neutral PMS2 P54278 G528M 528 G M 0.422 Neutral PMS2 P54278 G528N 528 G N 0.252 Neutral PMS2 P54278 G528P 528 G P 0.358 Neutral PMS2 P54278 G528Q 528 G Q 0.262 Neutral PMS2 P54278 G528R 528 G R 0.468 Neutral PMS2 P54278 G528S 528 G S 0.022 Neutral PMS2 P54278 G528T 528 G T 0.284 Neutral PMS2 P54278 G528V 528 G V 0.304 Neutral PMS2 P54278 G528W 528 G W 0.498 Neutral PMS2 P54278 G528Y 528 G Y 0.456 Neutral PMS2 P54278 S529A 529 S A 0.052 Neutral PMS2 P54278 S529C 529 S C 0.032 Neutral PMS2 P54278 S529D 529 S D 0.026 Neutral PMS2 P54278 S529E 529 S E 0.138 Neutral PMS2 P54278 S529F 529 S F 0.28 Neutral PMS2 P54278 S529G 529 S G 0.066 Neutral PMS2 P54278 S529H 529 S H 0.242 Neutral PMS2 P54278 S529I 529 S I 0.026 Neutral PMS2 P54278 S529K 529 S K 0.152 Neutral PMS2 P54278 S529L 529 S L 0.064 Neutral PMS2 P54278 S529M 529 S M 0.35 Neutral PMS2 P54278 S529N 529 S N 0.02 Neutral PMS2 P54278 S529P 529 S P 0.062 Neutral PMS2 P54278 S529Q 529 S Q 0.162 Neutral PMS2 P54278 S529R 529 S R 0.252 Neutral PMS2 P54278 S529T 529 S T 0.02 Neutral PMS2 P54278 S529V 529 S V 0.256 Neutral PMS2 P54278 S529W 529 S W 0.488 Neutral PMS2 P54278 S529Y 529 S Y 0.458 Neutral PMS2 P54278 N53A 53 N A 0.08 Neutral PMS2 P54278 N53C 53 N C 0.556 Pathogenic PMS2 P54278 N53D 53 N D 0.048 Neutral PMS2 P54278 N53E 53 N E 0.038 Neutral PMS2 P54278 N53F 53 N F 0.9 Pathogenic PMS2 P54278 N53G 53 N G 0.338 Neutral PMS2 P54278 N53H 53 N H 0.074 Neutral PMS2 P54278 N53I 53 N I 0.33 Neutral PMS2 P54278 N53K 53 N K 0.068 Neutral PMS2 P54278 N53L 53 N L 0.146 Neutral PMS2 P54278 N53M 53 N M 0.78 Pathogenic PMS2 P54278 N53P 53 N P 0.718 Pathogenic PMS2 P54278 N53Q 53 N Q 0.034 Neutral PMS2 P54278 N53R 53 N R 0.41 Neutral PMS2 P54278 N53S 53 N S 0.072 Neutral PMS2 P54278 N53T 53 N T 0.028 Neutral PMS2 P54278 N53V 53 N V 0.11 Neutral PMS2 P54278 N53W 53 N W 0.924 Pathogenic PMS2 P54278 N53Y 53 N Y 0.908 Pathogenic PMS2 P54278 Q530A 530 Q A 0.08 Neutral PMS2 P54278 Q530C 530 Q C 0.082 Neutral PMS2 P54278 Q530D 530 Q D 0.054 Neutral PMS2 P54278 Q530E 530 Q E 0.008 Neutral PMS2 P54278 Q530F 530 Q F 0.278 Neutral PMS2 P54278 Q530G 530 Q G 0.138 Neutral PMS2 P54278 Q530H 530 Q H 0.216 Neutral PMS2 P54278 Q530I 530 Q I 0.286 Neutral PMS2 P54278 Q530K 530 Q K 0.054 Neutral PMS2 P54278 Q530L 530 Q L 0.116 Neutral PMS2 P54278 Q530M 530 Q M 0.188 Neutral PMS2 P54278 Q530N 530 Q N 0.094 Neutral PMS2 P54278 Q530P 530 Q P 0.3 Neutral PMS2 P54278 Q530R 530 Q R 0.002 Neutral PMS2 P54278 Q530S 530 Q S 0.186 Neutral PMS2 P54278 Q530T 530 Q T 0.132 Neutral PMS2 P54278 Q530V 530 Q V 0.274 Neutral PMS2 P54278 Q530W 530 Q W 0.45 Neutral PMS2 P54278 Q530Y 530 Q Y 0.38 Neutral PMS2 P54278 E531A 531 E A 0.144 Neutral PMS2 P54278 E531C 531 E C 0.068 Neutral PMS2 P54278 E531D 531 E D 0.004 Neutral PMS2 P54278 E531F 531 E F 0.172 Neutral PMS2 P54278 E531G 531 E G 0 Neutral PMS2 P54278 E531H 531 E H 0.106 Neutral PMS2 P54278 E531I 531 E I 0.264 Neutral PMS2 P54278 E531K 531 E K 0.164 Neutral PMS2 P54278 E531L 531 E L 0.304 Neutral PMS2 P54278 E531M 531 E M 0.172 Neutral PMS2 P54278 E531N 531 E N 0.036 Neutral PMS2 P54278 E531P 531 E P 0.314 Neutral PMS2 P54278 E531Q 531 E Q 0.012 Neutral PMS2 P54278 E531R 531 E R 0.046 Neutral PMS2 P54278 E531S 531 E S 0.018 Neutral PMS2 P54278 E531T 531 E T 0.176 Neutral PMS2 P54278 E531V 531 E V 0.264 Neutral PMS2 P54278 E531W 531 E W 0.476 Neutral PMS2 P54278 E531Y 531 E Y 0.374 Neutral PMS2 P54278 H532A 532 H A 0.076 Neutral PMS2 P54278 H532C 532 H C 0.042 Neutral PMS2 P54278 H532D 532 H D 0.04 Neutral PMS2 P54278 H532E 532 H E 0.028 Neutral PMS2 P54278 H532F 532 H F 0.034 Neutral PMS2 P54278 H532G 532 H G 0.11 Neutral PMS2 P54278 H532I 532 H I 0.258 Neutral PMS2 P54278 H532K 532 H K 0.004 Neutral PMS2 P54278 H532L 532 H L 0.104 Neutral PMS2 P54278 H532M 532 H M 0.136 Neutral PMS2 P54278 H532N 532 H N 0.002 Neutral PMS2 P54278 H532P 532 H P 0.21 Neutral PMS2 P54278 H532Q 532 H Q 0.094 Neutral PMS2 P54278 H532R 532 H R 0.016 Neutral PMS2 P54278 H532S 532 H S 0.012 Neutral PMS2 P54278 H532T 532 H T 0.062 Neutral PMS2 P54278 H532V 532 H V 0.132 Neutral PMS2 P54278 H532W 532 H W 0.404 Neutral PMS2 P54278 H532Y 532 H Y 0.076 Neutral PMS2 P54278 V533A 533 V A 0 Neutral PMS2 P54278 V533C 533 V C 0.008 Neutral PMS2 P54278 V533D 533 V D 0.122 Neutral PMS2 P54278 V533E 533 V E 0.042 Neutral PMS2 P54278 V533F 533 V F 0.142 Neutral PMS2 P54278 V533G 533 V G 0.118 Neutral PMS2 P54278 V533H 533 V H 0.068 Neutral PMS2 P54278 V533I 533 V I 0.008 Neutral PMS2 P54278 V533K 533 V K 0.116 Neutral PMS2 P54278 V533L 533 V L 0.004 Neutral PMS2 P54278 V533M 533 V M 0.014 Neutral PMS2 P54278 V533N 533 V N 0.144 Neutral PMS2 P54278 V533P 533 V P 0.19 Neutral PMS2 P54278 V533Q 533 V Q 0.216 Neutral PMS2 P54278 V533R 533 V R 0.21 Neutral PMS2 P54278 V533S 533 V S 0.01 Neutral PMS2 P54278 V533T 533 V T 0.03 Neutral PMS2 P54278 V533W 533 V W 0.344 Neutral PMS2 P54278 V533Y 533 V Y 0.256 Neutral PMS2 P54278 D534A 534 D A 0.014 Neutral PMS2 P54278 D534C 534 D C 0.17 Neutral PMS2 P54278 D534E 534 D E 0.01 Neutral PMS2 P54278 D534F 534 D F 0.296 Neutral PMS2 P54278 D534G 534 D G 0.082 Neutral PMS2 P54278 D534H 534 D H 0.09 Neutral PMS2 P54278 D534I 534 D I 0.108 Neutral PMS2 P54278 D534K 534 D K 0.052 Neutral PMS2 P54278 D534L 534 D L 0.256 Neutral PMS2 P54278 D534M 534 D M 0.19 Neutral PMS2 P54278 D534N 534 D N 0 Neutral PMS2 P54278 D534P 534 D P 0.288 Neutral PMS2 P54278 D534Q 534 D Q 0.172 Neutral PMS2 P54278 D534R 534 D R 0.166 Neutral PMS2 P54278 D534S 534 D S 0.002 Neutral PMS2 P54278 D534T 534 D T 0.012 Neutral PMS2 P54278 D534V 534 D V 0.262 Neutral PMS2 P54278 D534W 534 D W 0.434 Neutral PMS2 P54278 D534Y 534 D Y 0.404 Neutral PMS2 P54278 S535A 535 S A 0.01 Neutral PMS2 P54278 S535C 535 S C 0.002 Neutral PMS2 P54278 S535D 535 S D 0.03 Neutral PMS2 P54278 S535E 535 S E 0.17 Neutral PMS2 P54278 S535F 535 S F 0.308 Neutral PMS2 P54278 S535G 535 S G 0.066 Neutral PMS2 P54278 S535H 535 S H 0.19 Neutral PMS2 P54278 S535I 535 S I 0.036 Neutral PMS2 P54278 S535K 535 S K 0.188 Neutral PMS2 P54278 S535L 535 S L 0.038 Neutral PMS2 P54278 S535M 535 S M 0.384 Neutral PMS2 P54278 S535N 535 S N 0.016 Neutral PMS2 P54278 S535P 535 S P 0.144 Neutral PMS2 P54278 S535Q 535 S Q 0.172 Neutral PMS2 P54278 S535R 535 S R 0.276 Neutral PMS2 P54278 S535T 535 S T 0.046 Neutral PMS2 P54278 S535V 535 S V 0.036 Neutral PMS2 P54278 S535W 535 S W 0.532 Pathogenic PMS2 P54278 S535Y 535 S Y 0.488 Neutral PMS2 P54278 Q536A 536 Q A 0.08 Neutral PMS2 P54278 Q536C 536 Q C 0 Neutral PMS2 P54278 Q536D 536 Q D 0 Neutral PMS2 P54278 Q536E 536 Q E 0.008 Neutral PMS2 P54278 Q536F 536 Q F 0.26 Neutral PMS2 P54278 Q536G 536 Q G 0.03 Neutral PMS2 P54278 Q536H 536 Q H 0.034 Neutral PMS2 P54278 Q536I 536 Q I 0.278 Neutral PMS2 P54278 Q536K 536 Q K 0.02 Neutral PMS2 P54278 Q536L 536 Q L 0.124 Neutral PMS2 P54278 Q536M 536 Q M 0.186 Neutral PMS2 P54278 Q536N 536 Q N 0.064 Neutral PMS2 P54278 Q536P 536 Q P 0.22 Neutral PMS2 P54278 Q536R 536 Q R 0.002 Neutral PMS2 P54278 Q536S 536 Q S 0.054 Neutral PMS2 P54278 Q536T 536 Q T 0.144 Neutral PMS2 P54278 Q536V 536 Q V 0.26 Neutral PMS2 P54278 Q536W 536 Q W 0.42 Neutral PMS2 P54278 Q536Y 536 Q Y 0.452 Neutral PMS2 P54278 E537A 537 E A 0.122 Neutral PMS2 P54278 E537C 537 E C 0.068 Neutral PMS2 P54278 E537D 537 E D 0 Neutral PMS2 P54278 E537F 537 E F 0.312 Neutral PMS2 P54278 E537G 537 E G 0 Neutral PMS2 P54278 E537H 537 E H 0.162 Neutral PMS2 P54278 E537I 537 E I 0.158 Neutral PMS2 P54278 E537K 537 E K 0.068 Neutral PMS2 P54278 E537L 537 E L 0.038 Neutral PMS2 P54278 E537M 537 E M 0.076 Neutral PMS2 P54278 E537N 537 E N 0.036 Neutral PMS2 P54278 E537P 537 E P 0.124 Neutral PMS2 P54278 E537Q 537 E Q 0.012 Neutral PMS2 P54278 E537R 537 E R 0.016 Neutral PMS2 P54278 E537S 537 E S 0.168 Neutral PMS2 P54278 E537T 537 E T 0.08 Neutral PMS2 P54278 E537V 537 E V 0.25 Neutral PMS2 P54278 E537W 537 E W 0.43 Neutral PMS2 P54278 E537Y 537 E Y 0.338 Neutral PMS2 P54278 K538A 538 K A 0.056 Neutral PMS2 P54278 K538C 538 K C 0.028 Neutral PMS2 P54278 K538D 538 K D 0.066 Neutral PMS2 P54278 K538E 538 K E 0.004 Neutral PMS2 P54278 K538F 538 K F 0.212 Neutral PMS2 P54278 K538G 538 K G 0.13 Neutral PMS2 P54278 K538H 538 K H 0.048 Neutral PMS2 P54278 K538I 538 K I 0.19 Neutral PMS2 P54278 K538L 538 K L 0.148 Neutral PMS2 P54278 K538M 538 K M 0.106 Neutral PMS2 P54278 K538N 538 K N 0.014 Neutral PMS2 P54278 K538P 538 K P 0.01 Neutral PMS2 P54278 K538Q 538 K Q 0.006 Neutral PMS2 P54278 K538R 538 K R 0.012 Neutral PMS2 P54278 K538S 538 K S 0.22 Neutral PMS2 P54278 K538T 538 K T 0.028 Neutral PMS2 P54278 K538V 538 K V 0.18 Neutral PMS2 P54278 K538W 538 K W 0.396 Neutral PMS2 P54278 K538Y 538 K Y 0.326 Neutral PMS2 P54278 A539C 539 A C 0.182 Neutral PMS2 P54278 A539D 539 A D 0.266 Neutral PMS2 P54278 A539E 539 A E 0.286 Neutral PMS2 P54278 A539F 539 A F 0.408 Neutral PMS2 P54278 A539G 539 A G 0.12 Neutral PMS2 P54278 A539H 539 A H 0.304 Neutral PMS2 P54278 A539I 539 A I 0.334 Neutral PMS2 P54278 A539K 539 A K 0.32 Neutral PMS2 P54278 A539L 539 A L 0.312 Neutral PMS2 P54278 A539M 539 A M 0.29 Neutral PMS2 P54278 A539N 539 A N 0.274 Neutral PMS2 P54278 A539P 539 A P 0.138 Neutral PMS2 P54278 A539Q 539 A Q 0.278 Neutral PMS2 P54278 A539R 539 A R 0.36 Neutral PMS2 P54278 A539S 539 A S 0.006 Neutral PMS2 P54278 A539T 539 A T 0.012 Neutral PMS2 P54278 A539V 539 A V 0.136 Neutral PMS2 P54278 A539W 539 A W 0.504 Pathogenic PMS2 P54278 A539Y 539 A Y 0.5 Pathogenic PMS2 P54278 I54A 54 I A 0.466 Neutral PMS2 P54278 I54C 54 I C 0.606 Pathogenic PMS2 P54278 I54D 54 I D 0.748 Pathogenic PMS2 P54278 I54E 54 I E 0.758 Pathogenic PMS2 P54278 I54F 54 I F 0.96 Pathogenic PMS2 P54278 I54G 54 I G 0.798 Pathogenic PMS2 P54278 I54H 54 I H 0.848 Pathogenic PMS2 P54278 I54K 54 I K 0.848 Pathogenic PMS2 P54278 I54L 54 I L 0.348 Neutral PMS2 P54278 I54M 54 I M 0.256 Neutral PMS2 P54278 I54N 54 I N 0.774 Pathogenic PMS2 P54278 I54P 54 I P 0.934 Pathogenic PMS2 P54278 I54Q 54 I Q 0.788 Pathogenic PMS2 P54278 I54R 54 I R 0.874 Pathogenic PMS2 P54278 I54S 54 I S 0.618 Pathogenic PMS2 P54278 I54T 54 I T 0.336 Neutral PMS2 P54278 I54V 54 I V 0.122 Neutral PMS2 P54278 I54W 54 I W 0.986 Pathogenic PMS2 P54278 I54Y 54 I Y 0.976 Pathogenic PMS2 P54278 P540A 540 P A 0.116 Neutral PMS2 P54278 P540C 540 P C 0.148 Neutral PMS2 P54278 P540D 540 P D 0.028 Neutral PMS2 P54278 P540E 540 P E 0.214 Neutral PMS2 P54278 P540F 540 P F 0.272 Neutral PMS2 P54278 P540G 540 P G 0.066 Neutral PMS2 P54278 P540H 540 P H 0.226 Neutral PMS2 P54278 P540I 540 P I 0.1 Neutral PMS2 P54278 P540K 540 P K 0.144 Neutral PMS2 P54278 P540L 540 P L 0.046 Neutral PMS2 P54278 P540M 540 P M 0.22 Neutral PMS2 P54278 P540N 540 P N 0.048 Neutral PMS2 P54278 P540Q 540 P Q 0.212 Neutral PMS2 P54278 P540R 540 P R 0.214 Neutral PMS2 P54278 P540S 540 P S 0.092 Neutral PMS2 P54278 P540T 540 P T 0.034 Neutral PMS2 P54278 P540V 540 P V 0.04 Neutral PMS2 P54278 P540W 540 P W 0.39 Neutral PMS2 P54278 P540Y 540 P Y 0.32 Neutral PMS2 P54278 K541A 541 K A 0.028 Neutral PMS2 P54278 K541C 541 K C 0.036 Neutral PMS2 P54278 K541D 541 K D 0.002 Neutral PMS2 P54278 K541E 541 K E 0.004 Neutral 1 PMS2 P54278 K541F 541 K F 0.212 Neutral PMS2 P54278 K541G 541 K G 0.042 Neutral PMS2 P54278 K541H 541 K H 0.048 Neutral PMS2 P54278 K541I 541 K I 0.222 Neutral PMS2 P54278 K541L 541 K L 0.214 Neutral PMS2 P54278 K541M 541 K M 0.106 Neutral PMS2 P54278 K541N 541 K N 0.082 Neutral PMS2 P54278 K541P 541 K P 0.214 Neutral PMS2 P54278 K541Q 541 K Q 0.048 Neutral PMS2 P54278 K541R 541 K R 0.016 Neutral PMS2 P54278 K541S 541 K S 0.22 Neutral PMS2 P54278 K541T 541 K T 0.012 Neutral PMS2 P54278 K541V 541 K V 0.184 Neutral PMS2 P54278 K541W 541 K W 0.396 Neutral PMS2 P54278 K541Y 541 K Y 0.326 Neutral PMS2 P54278 T542A 542 T A 0.06 Neutral PMS2 P54278 T542C 542 T C 0.004 Neutral PMS2 P54278 T542D 542 T D 0.046 Neutral PMS2 P54278 T542E 542 T E 0.05 Neutral PMS2 P54278 T542F 542 T F 0.204 Neutral PMS2 P54278 T542G 542 T G 0.058 Neutral PMS2 P54278 T542H 542 T H 0.036 Neutral PMS2 P54278 T542I 542 T I 0.076 Neutral PMS2 P54278 T542K 542 T K 0.026 Neutral PMS2 P54278 T542L 542 T L 0.008 Neutral PMS2 P54278 T542M 542 T M 0.044 Neutral PMS2 P54278 T542N 542 T N 0.002 Neutral PMS2 P54278 T542P 542 T P 0.008 Neutral PMS2 P54278 T542Q 542 T Q 0.016 Neutral PMS2 P54278 T542R 542 T R 0.174 Neutral PMS2 P54278 T542S 542 T S 0.032 Neutral PMS2 P54278 T542V 542 T V 0.212 Neutral PMS2 P54278 T542W 542 T W 0.466 Neutral PMS2 P54278 T542Y 542 T Y 0.422 Neutral PMS2 P54278 D543A 543 D A 0.014 Neutral PMS2 P54278 D543C 543 D C 0.17 Neutral PMS2 P54278 D543E 543 D E 0.038 Neutral PMS2 P54278 D543F 543 D F 0.37 Neutral PMS2 P54278 D543G 543 D G 0.018 Neutral PMS2 P54278 D543H 543 D H 0.09 Neutral PMS2 P54278 D543I 543 D I 0.262 Neutral PMS2 P54278 D543K 543 D K 0.052 Neutral PMS2 P54278 D543L 543 D L 0.256 Neutral PMS2 P54278 D543M 543 D M 0.106 Neutral PMS2 P54278 D543N 543 D N 0.02 Neutral PMS2 P54278 D543P 543 D P 0.066 Neutral PMS2 P54278 D543Q 543 D Q 0.172 Neutral PMS2 P54278 D543R 543 D R 0.152 Neutral PMS2 P54278 D543S 543 D S 0.002 Neutral PMS2 P54278 D543T 543 D T 0.154 Neutral PMS2 P54278 D543V 543 D V 0.262 Neutral PMS2 P54278 D543W 543 D W 0.434 Neutral PMS2 P54278 D543Y 543 D Y 0.404 Neutral PMS2 P54278 D544A 544 D A 0.082 Neutral PMS2 P54278 D544C 544 D C 0.056 Neutral PMS2 P54278 D544E 544 D E 0.014 Neutral PMS2 P54278 D544F 544 D F 0.37 Neutral PMS2 P54278 D544G 544 D G 0.17 Neutral PMS2 P54278 D544H 544 D H 0.028 Neutral PMS2 P54278 D544I 544 D I 0.302 Neutral PMS2 P54278 D544K 544 D K 0.21 Neutral PMS2 P54278 D544L 544 D L 0.108 Neutral PMS2 P54278 D544M 544 D M 0.19 Neutral PMS2 P54278 D544N 544 D N 0.02 Neutral PMS2 P54278 D544P 544 D P 0.038 Neutral PMS2 P54278 D544Q 544 D Q 0.014 Neutral PMS2 P54278 D544R 544 D R 0.166 Neutral PMS2 P54278 D544S 544 D S 0.002 Neutral PMS2 P54278 D544T 544 D T 0.032 Neutral PMS2 P54278 D544V 544 D V 0.262 Neutral PMS2 P54278 D544W 544 D W 0.434 Neutral PMS2 P54278 D544Y 544 D Y 0.432 Neutral PMS2 P54278 S545A 545 S A 0.018 Neutral PMS2 P54278 S545C 545 S C 0.022 Neutral PMS2 P54278 S545D 545 S D 0.002 Neutral PMS2 P54278 S545E 545 S E 0.138 Neutral PMS2 P54278 S545F 545 S F 0.264 Neutral PMS2 P54278 S545G 545 S G 0.064 Neutral PMS2 P54278 S545H 545 S H 0.186 Neutral PMS2 P54278 S545I 545 S I 0.026 Neutral PMS2 P54278 S545K 545 S K 0.162 Neutral PMS2 P54278 S545L 545 S L 0.068 Neutral PMS2 P54278 S545M 545 S M 0.332 Neutral PMS2 P54278 S545N 545 S N 0.012 Neutral PMS2 P54278 S545P 545 S P 0.064 Neutral PMS2 P54278 S545Q 545 S Q 0.17 Neutral PMS2 P54278 S545R 545 S R 0.152 Neutral PMS2 P54278 S545T 545 S T 0.176 Neutral PMS2 P54278 S545V 545 S V 0.248 Neutral PMS2 P54278 S545W 545 S W 0.49 Neutral PMS2 P54278 S545Y 545 S Y 0.434 Neutral PMS2 P54278 F546A 546 F A 0.112 Neutral PMS2 P54278 F546C 546 F C 0.072 Neutral PMS2 P54278 F546D 546 F D 0.104 Neutral PMS2 P54278 F546E 546 F E 0.184 Neutral PMS2 P54278 F546G 546 F G 0.146 Neutral PMS2 P54278 F546H 546 F H 0.072 Neutral PMS2 P54278 F546I 546 F I 0.076 Neutral PMS2 P54278 F546K 546 F K 0.174 Neutral PMS2 P54278 F546L 546 F L 0.002 Neutral PMS2 P54278 F546M 546 F M 0.086 Neutral PMS2 P54278 F546N 546 F N 0.114 Neutral PMS2 P54278 F546P 546 F P 0.03 Neutral PMS2 P54278 F546Q 546 F Q 0.116 Neutral PMS2 P54278 F546R 546 F R 0.142 Neutral PMS2 P54278 F546S 546 F S 0.014 Neutral PMS2 P54278 F546T 546 F T 0.092 Neutral PMS2 P54278 F546V 546 F V 0.166 Neutral PMS2 P54278 F546W 546 F W 0.268 Neutral PMS2 P54278 F546Y 546 F Y 0.02 Neutral PMS2 P54278 S547A 547 S A 0.01 Neutral PMS2 P54278 S547C 547 S C 0.032 Neutral PMS2 P54278 S547D 547 S D 0.024 Neutral PMS2 P54278 S547E 547 S E 0.124 Neutral PMS2 P54278 S547F 547 S F 0.276 Neutral PMS2 P54278 S547G 547 S G 0.066 Neutral PMS2 P54278 S547H 547 S H 0.188 Neutral PMS2 P54278 S547I 547 S I 0.026 Neutral PMS2 P54278 S547K 547 S K 0.14 Neutral PMS2 P54278 S547L 547 S L 0.026 Neutral PMS2 P54278 S547M 547 S M 0.332 Neutral PMS2 P54278 S547N 547 S N 0.034 Neutral PMS2 P54278 S547P 547 S P 0.062 Neutral PMS2 P54278 S547Q 547 S Q 0.17 Neutral PMS2 P54278 S547R 547 S R 0.136 Neutral PMS2 P54278 S547T 547 S T 0.11 Neutral PMS2 P54278 S547V 547 S V 0.248 Neutral PMS2 P54278 S547W 547 S W 0.472 Neutral PMS2 P54278 S547Y 547 S Y 0.404 Neutral PMS2 P54278 D548A 548 D A 0.014 Neutral PMS2 P54278 D548C 548 D C 0.148 Neutral PMS2 P54278 D548E 548 D E 0.014 Neutral PMS2 P54278 D548F 548 D F 0.37 Neutral PMS2 P54278 D548G 548 D G 0.018 Neutral PMS2 P54278 D548H 548 D H 0.154 Neutral PMS2 P54278 D548I 548 D I 0.116 Neutral PMS2 P54278 D548K 548 D K 0.176 Neutral PMS2 P54278 D548L 548 D L 0.262 Neutral PMS2 P54278 D548M 548 D M 0.19 Neutral PMS2 P54278 D548N 548 D N 0 Neutral PMS2 P54278 D548P 548 D P 0.038 Neutral PMS2 P54278 D548Q 548 D Q 0.078 Neutral PMS2 P54278 D548R 548 D R 0.128 Neutral PMS2 P54278 D548S 548 D S 0.074 Neutral PMS2 P54278 D548T 548 D T 0.154 Neutral PMS2 P54278 D548V 548 D V 0.242 Neutral PMS2 P54278 D548W 548 D W 0.434 Neutral PMS2 P54278 D548Y 548 D Y 0.404 Neutral PMS2 P54278 V549A 549 V A 0 Neutral PMS2 P54278 V549C 549 V C 0.008 Neutral PMS2 P54278 V549D 549 V D 0.026 Neutral PMS2 P54278 V549E 549 V E 0.098 Neutral PMS2 P54278 V549F 549 V F 0.172 Neutral PMS2 P54278 V549G 549 V G 0.178 Neutral PMS2 P54278 V549H 549 V H 0.048 Neutral PMS2 P54278 V549I 549 V I 0.038 Neutral PMS2 P54278 V549K 549 V K 0.138 Neutral PMS2 P54278 V549L 549 V L 0.018 Neutral PMS2 P54278 V549M 549 V M 0.014 Neutral PMS2 P54278 V549N 549 V N 0.05 Neutral PMS2 P54278 V549P 549 V P 0.036 Neutral PMS2 P54278 V549Q 549 V Q 0.216 Neutral PMS2 P54278 V549R 549 V R 0.208 Neutral PMS2 P54278 V549S 549 V S 0.024 Neutral PMS2 P54278 V549T 549 V T 0.008 Neutral PMS2 P54278 V549W 549 V W 0.344 Neutral PMS2 P54278 V549Y 549 V Y 0.162 Neutral PMS2 P54278 D55A 55 D A 0.38 Neutral PMS2 P54278 D55C 55 D C 0.732 Pathogenic PMS2 P54278 D55E 55 D E 0.084 Neutral PMS2 P54278 D55F 55 D F 0.928 Pathogenic PMS2 P54278 D55G 55 D G 0.406 Neutral PMS2 P54278 D55H 55 D H 0.444 Neutral PMS2 P54278 D55I 55 D I 0.89 Pathogenic PMS2 P54278 D55K 55 D K 0.732 Pathogenic PMS2 P54278 D55L 55 D L 0.89 Pathogenic PMS2 P54278 D55M 55 D M 0.804 Pathogenic PMS2 P54278 D55N 55 D N 0.308 Neutral PMS2 P54278 D55P 55 D P 0.806 Pathogenic PMS2 P54278 D55Q 55 D Q 0.466 Neutral PMS2 P54278 D55R 55 D R 0.742 Pathogenic PMS2 P54278 D55S 55 D S 0.196 Neutral PMS2 P54278 D55T 55 D T 0.576 Pathogenic PMS2 P54278 D55V 55 D V 0.822 Pathogenic PMS2 P54278 D55W 55 D W 0.97 Pathogenic PMS2 P54278 D55Y 55 D Y 0.964 Pathogenic PMS2 P54278 D550A 550 D A 0.072 Neutral PMS2 P54278 D550C 550 D C 0.148 Neutral PMS2 P54278 D550E 550 D E 0.01 Neutral PMS2 P54278 D550F 550 D F 0.37 Neutral PMS2 P54278 D550G 550 D G 0.022 Neutral PMS2 P54278 D550H 550 D H 0.09 Neutral PMS2 P54278 D550I 550 D I 0.302 Neutral PMS2 P54278 D550K 550 D K 0.02 Neutral PMS2 P54278 D550L 550 D L 0.262 Neutral PMS2 P54278 D550M 550 D M 0.19 Neutral PMS2 P54278 D550N 550 D N 0 Neutral PMS2 P54278 D550P 550 D P 0.31 Neutral PMS2 P54278 D550Q 550 D Q 0.078 Neutral PMS2 P54278 D550R 550 D R 0.15 Neutral PMS2 P54278 D550S 550 D S 0.196 Neutral PMS2 P54278 D550T 550 D T 0.1 Neutral PMS2 P54278 D550V 550 D V 0.07 Neutral PMS2 P54278 D550W 550 D W 0.434 Neutral PMS2 P54278 D550Y 550 D Y 0.404 Neutral PMS2 P54278 C551A 551 C A 0.078 Neutral PMS2 P54278 C551D 551 C D 0.026 Neutral PMS2 P54278 C551E 551 C E 0.112 Neutral PMS2 P54278 C551F 551 C F 0.412 Neutral PMS2 P54278 C551G 551 C G 0.158 Neutral PMS2 P54278 C551H 551 C H 0.102 Neutral PMS2 P54278 C551I 551 C I 0.27 Neutral PMS2 P54278 C551K 551 C K 0.208 Neutral PMS2 P54278 C551L 551 C L 0.308 Neutral PMS2 P54278 C551M 551 C M 0.136 Neutral PMS2 P54278 C551N 551 C N 0.04 Neutral PMS2 P54278 C551P 551 C P 0.054 Neutral PMS2 P54278 C551Q 551 C Q 0.082 Neutral PMS2 P54278 C551R 551 C R 0.2 Neutral PMS2 P54278 C551S 551 C S 0.092 Neutral PMS2 P54278 C551T 551 C T 0.142 Neutral PMS2 P54278 C551V 551 C V 0.012 Neutral PMS2 P54278 C551W 551 C W 0.458 Neutral PMS2 P54278 C551Y 551 C Y 0.444 Neutral PMS2 P54278 H552A 552 H A 0.062 Neutral PMS2 P54278 H552C 552 H C 0 Neutral PMS2 P54278 H552D 552 H D 0 Neutral PMS2 P54278 H552E 552 H E 0.002 Neutral PMS2 P54278 H552F 552 H F 0.204 Neutral PMS2 P54278 H552G 552 H G 0.042 Neutral PMS2 P54278 H552I 552 H I 0.258 Neutral PMS2 P54278 H552K 552 H K 0.008 Neutral PMS2 P54278 H552L 552 H L 0.232 Neutral PMS2 P54278 H552M 552 H M 0.108 Neutral PMS2 P54278 H552N 552 H N 0.058 Neutral PMS2 P54278 H552P 552 H P 0.028 Neutral PMS2 P54278 H552Q 552 H Q 0.05 Neutral PMS2 P54278 H552R 552 H R 0.016 Neutral PMS2 P54278 H552S 552 H S 0.092 Neutral PMS2 P54278 H552T 552 H T 0.008 Neutral PMS2 P54278 H552V 552 H V 0.132 Neutral PMS2 P54278 H552W 552 H W 0.398 Neutral PMS2 P54278 H552Y 552 H Y 0.252 Neutral PMS2 P54278 S553A 553 S A 0.086 Neutral PMS2 P54278 S553C 553 S C 0.032 Neutral PMS2 P54278 S553D 553 S D 0.024 Neutral PMS2 P54278 S553E 553 S E 0.148 Neutral PMS2 P54278 S553F 553 S F 0.25 Neutral PMS2 P54278 S553G 553 S G 0.064 Neutral PMS2 P54278 S553H 553 S H 0.238 Neutral PMS2 P54278 S553I 553 S I 0.124 Neutral PMS2 P54278 S553K 553 S K 0.164 Neutral PMS2 P54278 S553L 553 S L 0.026 Neutral PMS2 P54278 S553M 553 S M 0.332 Neutral PMS2 P54278 S553N 553 S N 0.012 Neutral PMS2 P54278 S553P 553 S P 0.062 Neutral PMS2 P54278 S553Q 553 S Q 0.16 Neutral PMS2 P54278 S553R 553 S R 0.152 Neutral PMS2 P54278 S553T 553 S T 0.046 Neutral PMS2 P54278 S553V 553 S V 0.038 Neutral PMS2 P54278 S553W 553 S W 0.49 Neutral PMS2 P54278 S553Y 553 S Y 0.448 Neutral PMS2 P54278 N554A 554 N A 0.052 Neutral PMS2 P54278 N554C 554 N C 0.092 Neutral PMS2 P54278 N554D 554 N D 0.008 Neutral PMS2 P54278 N554E 554 N E 0.016 Neutral PMS2 P54278 N554F 554 N F 0.34 Neutral PMS2 P54278 N554G 554 N G 0.02 Neutral PMS2 P54278 N554H 554 N H 0.07 Neutral PMS2 P54278 N554I 554 N I 0.336 Neutral PMS2 P54278 N554K 554 N K 0.038 Neutral PMS2 P54278 N554L 554 N L 0.172 Neutral PMS2 P54278 N554M 554 N M 0.22 Neutral PMS2 P54278 N554P 554 N P 0.158 Neutral PMS2 P54278 N554Q 554 N Q 0.166 Neutral PMS2 P54278 N554R 554 N R 0.136 Neutral PMS2 P54278 N554S 554 N S 0 Neutral PMS2 P54278 N554T 554 N T 0.006 Neutral PMS2 P54278 N554V 554 N V 0.12 Neutral PMS2 P54278 N554W 554 N W 0.446 Neutral PMS2 P54278 N554Y 554 N Y 0.402 Neutral PMS2 P54278 Q555A 555 Q A 0.08 Neutral PMS2 P54278 Q555C 555 Q C 0.082 Neutral PMS2 P54278 Q555D 555 Q D 0.046 Neutral PMS2 P54278 Q555E 555 Q E 0.008 Neutral PMS2 P54278 Q555F 555 Q F 0.26 Neutral PMS2 P54278 Q555G 555 Q G 0.136 Neutral PMS2 P54278 Q555H 555 Q H 0.038 Neutral PMS2 P54278 Q555I 555 Q I 0.246 Neutral PMS2 P54278 Q555K 555 Q K 0.21 Neutral PMS2 P54278 Q555L 555 Q L 0.146 Neutral PMS2 P54278 Q555M 555 Q M 0.186 Neutral PMS2 P54278 Q555N 555 Q N 0.064 Neutral PMS2 P54278 Q555P 555 Q P 0.22 Neutral PMS2 P54278 Q555R 555 Q R 0.024 Neutral PMS2 P54278 Q555S 555 Q S 0.036 Neutral PMS2 P54278 Q555T 555 Q T 0.13 Neutral PMS2 P54278 Q555V 555 Q V 0.26 Neutral PMS2 P54278 Q555W 555 Q W 0.42 Neutral PMS2 P54278 Q555Y 555 Q Y 0.362 Neutral PMS2 P54278 E556A 556 E A 0.144 Neutral PMS2 P54278 E556C 556 E C 0.068 Neutral PMS2 P54278 E556D 556 E D 0.004 Neutral PMS2 P54278 E556F 556 E F 0.272 Neutral PMS2 P54278 E556G 556 E G 0.084 Neutral PMS2 P54278 E556H 556 E H 0.096 Neutral PMS2 P54278 E556I 556 E I 0.322 Neutral PMS2 P54278 E556K 556 E K 0.026 Neutral PMS2 P54278 E556L 556 E L 0.138 Neutral PMS2 P54278 E556M 556 E M 0.076 Neutral PMS2 P54278 E556N 556 E N 0.036 Neutral PMS2 P54278 E556P 556 E P 0.282 Neutral PMS2 P54278 E556Q 556 E Q 0.056 Neutral PMS2 P54278 E556R 556 E R 0.01 Neutral PMS2 P54278 E556S 556 E S 0.168 Neutral PMS2 P54278 E556T 556 E T 0.168 Neutral PMS2 P54278 E556V 556 E V 0.032 Neutral PMS2 P54278 E556W 556 E W 0.43 Neutral PMS2 P54278 E556Y 556 E Y 0.338 Neutral PMS2 P54278 D557A 557 D A 0.014 Neutral PMS2 P54278 D557C 557 D C 0.148 Neutral PMS2 P54278 D557E 557 D E 0.014 Neutral PMS2 P54278 D557F 557 D F 0.37 Neutral PMS2 P54278 D557G 557 D G 0.018 Neutral PMS2 P54278 D557H 557 D H 0.09 Neutral PMS2 P54278 D557I 557 D I 0.214 Neutral PMS2 P54278 D557K 557 D K 0.21 Neutral PMS2 P54278 D557L 557 D L 0.256 Neutral PMS2 P54278 D557M 557 D M 0.19 Neutral PMS2 P54278 D557N 557 D N 0 Neutral PMS2 P54278 D557P 557 D P 0.038 Neutral PMS2 P54278 D557Q 557 D Q 0.172 Neutral PMS2 P54278 D557R 557 D R 0.128 Neutral PMS2 P54278 D557S 557 D S 0.002 Neutral PMS2 P54278 D557T 557 D T 0.154 Neutral PMS2 P54278 D557V 557 D V 0.242 Neutral PMS2 P54278 D557W 557 D W 0.434 Neutral PMS2 P54278 D557Y 557 D Y 0.404 Neutral PMS2 P54278 T558A 558 T A 0.08 Neutral PMS2 P54278 T558C 558 T C 0.034 Neutral PMS2 P54278 T558D 558 T D 0.022 Neutral PMS2 P54278 T558E 558 T E 0.026 Neutral PMS2 P54278 T558F 558 T F 0.214 Neutral PMS2 P54278 T558G 558 T G 0.002 Neutral PMS2 P54278 T558H 558 T H 0.056 Neutral PMS2 P54278 T558I 558 T I 0.042 Neutral PMS2 P54278 T558K 558 T K 0.032 Neutral PMS2 P54278 T558L 558 T L 0.074 Neutral PMS2 P54278 T558M 558 T M 0.098 Neutral PMS2 P54278 T558N 558 T N 0 Neutral PMS2 P54278 T558P 558 T P 0.02 Neutral PMS2 P54278 T558Q 558 T Q 0.016 Neutral PMS2 P54278 T558R 558 T R 0.14 Neutral PMS2 P54278 T558S 558 T S 0 Neutral PMS2 P54278 T558V 558 T V 0.016 Neutral PMS2 P54278 T558W 558 T W 0.466 Neutral PMS2 P54278 T558Y 558 T Y 0.424 Neutral PMS2 P54278 G559A 559 G A 0.002 Neutral PMS2 P54278 G559C 559 G C 0.162 Neutral PMS2 P54278 G559D 559 G D 0.134 Neutral PMS2 P54278 G559E 559 G E 0.188 Neutral PMS2 P54278 G559F 559 G F 0.498 Neutral PMS2 P54278 G559H 559 G H 0.442 Neutral PMS2 P54278 G559I 559 G I 0.428 Neutral PMS2 P54278 G559K 559 G K 0.358 Neutral PMS2 P54278 G559L 559 G L 0.316 Neutral PMS2 P54278 G559M 559 G M 0.422 Neutral PMS2 P54278 G559N 559 G N 0.172 Neutral PMS2 P54278 G559P 559 G P 0.402 Neutral PMS2 P54278 G559Q 559 G Q 0.206 Neutral PMS2 P54278 G559R 559 G R 0.292 Neutral PMS2 P54278 G559S 559 G S 0.046 Neutral PMS2 P54278 G559T 559 G T 0.274 Neutral PMS2 P54278 G559V 559 G V 0.39 Neutral PMS2 P54278 G559W 559 G W 0.43 Neutral PMS2 P54278 G559Y 559 G Y 0.482 Neutral PMS2 P54278 L56A 56 L A 0.272 Neutral PMS2 P54278 L56C 56 L C 0.324 Neutral PMS2 P54278 L56D 56 L D 0.592 Pathogenic PMS2 P54278 L56E 56 L E 0.552 Pathogenic PMS2 P54278 L56F 56 L F 0.784 Pathogenic PMS2 P54278 L56G 56 L G 0.534 Pathogenic PMS2 P54278 L56H 56 L H 0.33 Neutral PMS2 P54278 L56I 56 L I 0.07 Neutral PMS2 P54278 L56K 56 L K 0.436 Neutral PMS2 P54278 L56M 56 L M 0.446 Neutral PMS2 P54278 L56N 56 L N 0.556 Pathogenic PMS2 P54278 L56P 56 L P 0.886 Pathogenic PMS2 P54278 L56Q 56 L Q 0.294 Neutral PMS2 P54278 L56R 56 L R 0.846 Pathogenic PMS2 P54278 L56S 56 L S 0.48 Neutral PMS2 P54278 L56T 56 L T 0.372 Neutral PMS2 P54278 L56V 56 L V 0.056 Neutral PMS2 P54278 L56W 56 L W 0.866 Pathogenic PMS2 P54278 L56Y 56 L Y 0.858 Pathogenic PMS2 P54278 C560A 560 C A 0.004 Neutral PMS2 P54278 C560D 560 C D 0.026 Neutral PMS2 P54278 C560E 560 C E 0.124 Neutral PMS2 P54278 C560F 560 C F 0.406 Neutral PMS2 P54278 C560G 560 C G 0.05 Neutral PMS2 P54278 C560H 560 C H 0.182 Neutral PMS2 P54278 C560I 560 C I 0.27 Neutral PMS2 P54278 C560K 560 C K 0.116 Neutral PMS2 P54278 C560L 560 C L 0.154 Neutral PMS2 P54278 C560M 560 C M 0.136 Neutral PMS2 P54278 C560N 560 C N 0 Neutral PMS2 P54278 C560P 560 C P 0.11 Neutral PMS2 P54278 C560Q 560 C Q 0.03 Neutral PMS2 P54278 C560R 560 C R 0.202 Neutral PMS2 P54278 C560S 560 C S 0.014 Neutral PMS2 P54278 C560T 560 C T 0 Neutral PMS2 P54278 C560V 560 C V 0.08 Neutral PMS2 P54278 C560W 560 C W 0.482 Neutral PMS2 P54278 C560Y 560 C Y 0.312 Neutral PMS2 P54278 K561A 561 K A 0.096 Neutral PMS2 P54278 K561C 561 K C 0.036 Neutral PMS2 P54278 K561D 561 K D 0.002 Neutral PMS2 P54278 K561E 561 K E 0.004 Neutral PMS2 P54278 K561F 561 K F 0.212 Neutral PMS2 P54278 K561G 561 K G 0.132 Neutral PMS2 P54278 K561H 561 K H 0.048 Neutral PMS2 P54278 K561I 561 K I 0.19 Neutral PMS2 P54278 K561L 561 K L 0.148 Neutral PMS2 P54278 K561M 561 K M 0.078 Neutral PMS2 P54278 K561N 561 K N 0.006 Neutral PMS2 P54278 K561P 561 K P 0.236 Neutral PMS2 P54278 K561Q 561 K Q 0.006 Neutral PMS2 P54278 K561R 561 K R 0.002 Neutral PMS2 P54278 K561S 561 K S 0.024 Neutral PMS2 P54278 K561T 561 K T 0.012 Neutral PMS2 P54278 K561V 561 K V 0.184 Neutral PMS2 P54278 K561W 561 K W 0.396 Neutral PMS2 P54278 K561Y 561 K Y 0.326 Neutral PMS2 P54278 F562A 562 F A 0.046 Neutral PMS2 P54278 F562C 562 F C 0.008 Neutral PMS2 P54278 F562D 562 F D 0.172 Neutral PMS2 P54278 F562E 562 F E 0.128 Neutral PMS2 P54278 F562G 562 F G 0.12 Neutral PMS2 P54278 F562H 562 F H 0.01 Neutral PMS2 P54278 F562I 562 F I 0.076 Neutral PMS2 P54278 F562K 562 F K 0.184 Neutral PMS2 P54278 F562L 562 F L 0.002 Neutral PMS2 P54278 F562M 562 F M 0.086 Neutral PMS2 P54278 F562N 562 F N 0.18 Neutral PMS2 P54278 F562P 562 F P 0.032 Neutral PMS2 P54278 F562Q 562 F Q 0.038 Neutral PMS2 P54278 F562R 562 F R 0.038 Neutral PMS2 P54278 F562S 562 F S 0.014 Neutral PMS2 P54278 F562T 562 F T 0.172 Neutral PMS2 P54278 F562V 562 F V 0.214 Neutral PMS2 P54278 F562W 562 F W 0.268 Neutral PMS2 P54278 F562Y 562 F Y 0.046 Neutral PMS2 P54278 R563A 563 R A 0.08 Neutral PMS2 P54278 R563C 563 R C 0.14 Neutral PMS2 P54278 R563D 563 R D 0.18 Neutral PMS2 P54278 R563E 563 R E 0.162 Neutral PMS2 P54278 R563F 563 R F 0.27 Neutral PMS2 P54278 R563G 563 R G 0.006 Neutral PMS2 P54278 R563H 563 R H 0.12 Neutral PMS2 P54278 R563I 563 R I 0.308 Neutral PMS2 P54278 R563K 563 R K 0.022 Neutral PMS2 P54278 R563L 563 R L 0.062 Neutral 2 PMS2 P54278 R563M 563 R M 0.164 Neutral PMS2 P54278 R563N 563 R N 0.01 Neutral PMS2 P54278 R563P 563 R P 0.106 Neutral PMS2 P54278 R563Q 563 R Q 0.01 Neutral PMS2 P54278 R563S 563 R S 0.02 Neutral PMS2 P54278 R563T 563 R T 0.016 Neutral PMS2 P54278 R563V 563 R V 0.094 Neutral PMS2 P54278 R563W 563 R W 0.384 Neutral PMS2 P54278 R563Y 563 R Y 0.284 Neutral PMS2 P54278 V564A 564 V A 0 Neutral PMS2 P54278 V564C 564 V C 0.056 Neutral PMS2 P54278 V564D 564 V D 0.122 Neutral PMS2 P54278 V564E 564 V E 0.042 Neutral PMS2 P54278 V564F 564 V F 0.172 Neutral PMS2 P54278 V564G 564 V G 0.178 Neutral PMS2 P54278 V564H 564 V H 0.112 Neutral PMS2 P54278 V564I 564 V I 0.038 Neutral PMS2 P54278 V564K 564 V K 0.06 Neutral PMS2 P54278 V564L 564 V L 0 Neutral PMS2 P54278 V564M 564 V M 0.03 Neutral PMS2 P54278 V564N 564 V N 0.038 Neutral PMS2 P54278 V564P 564 V P 0.036 Neutral PMS2 P54278 V564Q 564 V Q 0.158 Neutral PMS2 P54278 V564R 564 V R 0.21 Neutral PMS2 P54278 V564S 564 V S 0.07 Neutral PMS2 P54278 V564T 564 V T 0.008 Neutral PMS2 P54278 V564W 564 V W 0.344 Neutral PMS2 P54278 V564Y 564 V Y 0.256 Neutral PMS2 P54278 L565A 565 L A 0.088 Neutral PMS2 P54278 L565C 565 L C 0.094 Neutral PMS2 P54278 L565D 565 L D 0.092 Neutral PMS2 P54278 L565E 565 L E 0.144 Neutral PMS2 P54278 L565F 565 L F 0.242 Neutral PMS2 P54278 L565G 565 L G 0.186 Neutral PMS2 P54278 L565H 565 L H 0.022 Neutral PMS2 P54278 L565I 565 L I 0.03 Neutral PMS2 P54278 L565K 565 L K 0.178 Neutral PMS2 P54278 L565M 565 L M 0.08 Neutral PMS2 P54278 L565N 565 L N 0.148 Neutral PMS2 P54278 L565P 565 L P 0.088 Neutral PMS2 P54278 L565Q 565 L Q 0.064 Neutral PMS2 P54278 L565R 565 L R 0.218 Neutral PMS2 P54278 L565S 565 L S 0.01 Neutral PMS2 P54278 L565T 565 L T 0.096 Neutral PMS2 P54278 L565V 565 L V 0.17 Neutral PMS2 P54278 L565W 565 L W 0.27 Neutral PMS2 P54278 L565Y 565 L Y 0.284 Neutral PMS2 P54278 P566A 566 P A 0.178 Neutral PMS2 P54278 P566C 566 P C 0.152 Neutral PMS2 P54278 P566D 566 P D 0.078 Neutral PMS2 P54278 P566E 566 P E 0.184 Neutral PMS2 P54278 P566F 566 P F 0.29 Neutral PMS2 P54278 P566G 566 P G 0.07 Neutral PMS2 P54278 P566H 566 P H 0.28 Neutral PMS2 P54278 P566I 566 P I 0.11 Neutral PMS2 P54278 P566K 566 P K 0.22 Neutral PMS2 P54278 P566L 566 P L 0.046 Neutral PMS2 P54278 P566M 566 P M 0.234 Neutral PMS2 P54278 P566N 566 P N 0.068 Neutral PMS2 P54278 P566Q 566 P Q 0.058 Neutral PMS2 P54278 P566R 566 P R 0.222 Neutral PMS2 P54278 P566S 566 P S 0.092 Neutral PMS2 P54278 P566T 566 P T 0.192 Neutral PMS2 P54278 P566V 566 P V 0.144 Neutral PMS2 P54278 P566W 566 P W 0.408 Neutral PMS2 P54278 P566Y 566 P Y 0.338 Neutral PMS2 P54278 Q567A 567 Q A 0.08 Neutral PMS2 P54278 Q567C 567 Q C 0.082 Neutral PMS2 P54278 Q567D 567 Q D 0.088 Neutral PMS2 P54278 Q567E 567 Q E 0.012 Neutral PMS2 P54278 Q567F 567 Q F 0.26 Neutral PMS2 P54278 Q567G 567 Q G 0.136 Neutral PMS2 P54278 Q567H 567 Q H 0.214 Neutral PMS2 P54278 Q567I 567 Q I 0.278 Neutral PMS2 P54278 Q567K 567 Q K 0.21 Neutral PMS2 P54278 Q567L 567 Q L 0.332 Neutral PMS2 P54278 Q567M 567 Q M 0.186 Neutral PMS2 P54278 Q567N 567 Q N 0.026 Neutral PMS2 P54278 Q567P 567 Q P 0.218 Neutral PMS2 P54278 Q567R 567 Q R 0.022 Neutral PMS2 P54278 Q567S 567 Q S 0.184 Neutral PMS2 P54278 Q567T 567 Q T 0.13 Neutral PMS2 P54278 Q567V 567 Q V 0.036 Neutral PMS2 P54278 Q567W 567 Q W 0.42 Neutral PMS2 P54278 Q567Y 567 Q Y 0.452 Neutral PMS2 P54278 P568A 568 P A 0.032 Neutral PMS2 P54278 P568C 568 P C 0.126 Neutral PMS2 P54278 P568D 568 P D 0.05 Neutral PMS2 P54278 P568E 568 P E 0.214 Neutral PMS2 P54278 P568F 568 P F 0.272 Neutral PMS2 P54278 P568G 568 P G 0.092 Neutral PMS2 P54278 P568H 568 P H 0.226 Neutral PMS2 P54278 P568I 568 P I 0.104 Neutral PMS2 P54278 P568K 568 P K 0.206 Neutral PMS2 P54278 P568L 568 P L 0.096 Neutral PMS2 P54278 P568M 568 P M 0.22 Neutral PMS2 P54278 P568N 568 P N 0.068 Neutral PMS2 P54278 P568Q 568 P Q 0.06 Neutral PMS2 P54278 P568R 568 P R 0.214 Neutral PMS2 P54278 P568S 568 P S 0.002 Neutral PMS2 P54278 P568T 568 P T 0.188 Neutral PMS2 P54278 P568V 568 P V 0.07 Neutral PMS2 P54278 P568W 568 P W 0.39 Neutral PMS2 P54278 P568Y 568 P Y 0.27 Neutral PMS2 P54278 T569A 569 T A 0 Neutral PMS2 P54278 T569C 569 T C 0.034 Neutral PMS2 P54278 T569D 569 T D 0.046 Neutral PMS2 P54278 T569E 569 T E 0.032 Neutral PMS2 P54278 T569F 569 T F 0.204 Neutral PMS2 P54278 T569G 569 T G 0.036 Neutral PMS2 P54278 T569H 569 T H 0.056 Neutral PMS2 P54278 T569I 569 T I 0.076 Neutral PMS2 P54278 T569K 569 T K 0.032 Neutral PMS2 P54278 T569L 569 T L 0.07 Neutral PMS2 P54278 T569M 569 T M 0.098 Neutral PMS2 P54278 T569N 569 T N 0 Neutral PMS2 P54278 T569P 569 T P 0.056 Neutral PMS2 P54278 T569Q 569 T Q 0.052 Neutral PMS2 P54278 T569R 569 T R 0.26 Neutral PMS2 P54278 T569S 569 T S 0 Neutral PMS2 P54278 T569V 569 T V 0.046 Neutral PMS2 P54278 T569W 569 T W 0.466 Neutral PMS2 P54278 T569Y 569 T Y 0.424 Neutral PMS2 P54278 K57A 57 K A 0.07 Neutral PMS2 P54278 K57C 57 K C 0.168 Neutral PMS2 P54278 K57D 57 K D 0.236 Neutral PMS2 P54278 K57E 57 K E 0.266 Neutral PMS2 P54278 K57F 57 K F 0.768 Pathogenic PMS2 P54278 K57G 57 K G 0.096 Neutral PMS2 P54278 K57H 57 K H 0.122 Neutral PMS2 P54278 K57I 57 K I 0.822 Pathogenic PMS2 P54278 K57L 57 K L 0.784 Pathogenic PMS2 P54278 K57M 57 K M 0.564 Pathogenic PMS2 P54278 K57N 57 K N 0.03 Neutral PMS2 P54278 K57P 57 K P 0.8 Pathogenic PMS2 P54278 K57Q 57 K Q 0.06 Neutral PMS2 P54278 K57R 57 K R 0.064 Neutral PMS2 P54278 K57S 57 K S 0.024 Neutral PMS2 P54278 K57T 57 K T 0.25 Neutral PMS2 P54278 K57V 57 K V 0.728 Pathogenic PMS2 P54278 K57W 57 K W 0.948 Pathogenic PMS2 P54278 K57Y 57 K Y 0.884 Pathogenic PMS2 P54278 N570A 570 N A 0.052 Neutral PMS2 P54278 N570C 570 N C 0.148 Neutral PMS2 P54278 N570D 570 N D 0.008 Neutral PMS2 P54278 N570E 570 N E 0.086 Neutral PMS2 P54278 N570F 570 N F 0.34 Neutral PMS2 P54278 N570G 570 N G 0.16 Neutral PMS2 P54278 N570H 570 N H 0.07 Neutral PMS2 P54278 N570I 570 N I 0.336 Neutral PMS2 P54278 N570K 570 N K 0.038 Neutral PMS2 P54278 N570L 570 N L 0.314 Neutral PMS2 P54278 N570M 570 N M 0.116 Neutral PMS2 P54278 N570P 570 N P 0.13 Neutral PMS2 P54278 N570Q 570 N Q 0.096 Neutral PMS2 P54278 N570R 570 N R 0.148 Neutral PMS2 P54278 N570S 570 N S 0 Neutral PMS2 P54278 N570T 570 N T 0.116 Neutral PMS2 P54278 N570V 570 N V 0.12 Neutral PMS2 P54278 N570W 570 N W 0.446 Neutral PMS2 P54278 N570Y 570 N Y 0.402 Neutral PMS2 P54278 L571A 571 L A 0.022 Neutral PMS2 P54278 L571C 571 L C 0.056 Neutral PMS2 P54278 L571D 571 L D 0.092 Neutral PMS2 P54278 L571E 571 L E 0.038 Neutral PMS2 P54278 L571F 571 L F 0.242 Neutral PMS2 P54278 L571G 571 L G 0.184 Neutral PMS2 P54278 L571H 571 L H 0.084 Neutral PMS2 P54278 L571I 571 L I 0.024 Neutral 2 PMS2 P54278 L571K 571 L K 0.178 Neutral PMS2 P54278 L571M 571 L M 0.18 Neutral PMS2 P54278 L571N 571 L N 0.028 Neutral PMS2 P54278 L571P 571 L P 0.216 Neutral PMS2 P54278 L571Q 571 L Q 0.018 Neutral PMS2 P54278 L571R 571 L R 0.28 Neutral PMS2 P54278 L571S 571 L S 0.01 Neutral PMS2 P54278 L571T 571 L T 0.096 Neutral PMS2 P54278 L571V 571 L V 0 Neutral PMS2 P54278 L571W 571 L W 0.334 Neutral PMS2 P54278 L571Y 571 L Y 0.284 Neutral PMS2 P54278 A572C 572 A C 0.212 Neutral PMS2 P54278 A572D 572 A D 0.35 Neutral PMS2 P54278 A572E 572 A E 0.286 Neutral PMS2 P54278 A572F 572 A F 0.28 Neutral PMS2 P54278 A572G 572 A G 0.074 Neutral PMS2 P54278 A572H 572 A H 0.304 Neutral PMS2 P54278 A572I 572 A I 0.446 Neutral PMS2 P54278 A572K 572 A K 0.29 Neutral PMS2 P54278 A572L 572 A L 0.302 Neutral PMS2 P54278 A572M 572 A M 0.256 Neutral PMS2 P54278 A572N 572 A N 0.274 Neutral PMS2 P54278 A572P 572 A P 0.3 Neutral PMS2 P54278 A572Q 572 A Q 0.302 Neutral PMS2 P54278 A572R 572 A R 0.36 Neutral PMS2 P54278 A572S 572 A S 0.004 Neutral PMS2 P54278 A572T 572 A T 0.014 Neutral PMS2 P54278 A572V 572 A V 0.202 Neutral PMS2 P54278 A572W 572 A W 0.504 Pathogenic PMS2 P54278 A572Y 572 A Y 0.5 Pathogenic PMS2 P54278 T573A 573 T A 0 Neutral PMS2 P54278 T573C 573 T C 0.064 Neutral PMS2 P54278 T573D 573 T D 0.046 Neutral PMS2 P54278 T573E 573 T E 0.04 Neutral PMS2 P54278 T573F 573 T F 0.182 Neutral PMS2 P54278 T573G 573 T G 0.036 Neutral PMS2 P54278 T573H 573 T H 0.084 Neutral PMS2 P54278 T573I 573 T I 0.076 Neutral PMS2 P54278 T573K 573 T K 0.042 Neutral PMS2 P54278 T573L 573 T L 0.016 Neutral PMS2 P54278 T573M 573 T M 0.044 Neutral PMS2 P54278 T573N 573 T N 0.02 Neutral PMS2 P54278 T573P 573 T P 0.01 Neutral PMS2 P54278 T573Q 573 T Q 0.016 Neutral PMS2 P54278 T573R 573 T R 0.174 Neutral PMS2 P54278 T573S 573 T S 0.004 Neutral PMS2 P54278 T573V 573 T V 0.206 Neutral PMS2 P54278 T573W 573 T W 0.466 Neutral PMS2 P54278 T573Y 573 T Y 0.424 Neutral PMS2 P54278 P574A 574 P A 0.178 Neutral PMS2 P54278 P574C 574 P C 0.152 Neutral PMS2 P54278 P574D 574 P D 0.078 Neutral PMS2 P54278 P574E 574 P E 0.228 Neutral PMS2 P54278 P574F 574 P F 0.29 Neutral PMS2 P54278 P574G 574 P G 0.092 Neutral PMS2 P54278 P574H 574 P H 0.28 Neutral PMS2 P54278 P574I 574 P I 0.06 Neutral PMS2 P54278 P574K 574 P K 0.164 Neutral PMS2 P54278 P574L 574 P L 0.098 Neutral PMS2 P54278 P574M 574 P M 0.198 Neutral PMS2 P54278 P574N 574 P N 0.048 Neutral PMS2 P54278 P574Q 574 P Q 0.168 Neutral PMS2 P54278 P574R 574 P R 0.22 Neutral PMS2 P54278 P574S 574 P S 0.002 Neutral PMS2 P54278 P574T 574 P T 0.192 Neutral PMS2 P54278 P574V 574 P V 0.144 Neutral PMS2 P54278 P574W 574 P W 0.408 Neutral PMS2 P54278 P574Y 574 P Y 0.338 Neutral PMS2 P54278 N575A 575 N A 0.052 Neutral PMS2 P54278 N575C 575 N C 0.148 Neutral PMS2 P54278 N575D 575 N D 0.068 Neutral PMS2 P54278 N575E 575 N E 0.04 Neutral PMS2 P54278 N575F 575 N F 0.34 Neutral PMS2 P54278 N575G 575 N G 0.162 Neutral PMS2 P54278 N575H 575 N H 0.262 Neutral PMS2 P54278 N575I 575 N I 0.266 Neutral PMS2 P54278 N575K 575 N K 0.038 Neutral PMS2 P54278 N575L 575 N L 0.272 Neutral PMS2 P54278 N575M 575 N M 0.22 Neutral PMS2 P54278 N575P 575 N P 0.248 Neutral PMS2 P54278 N575Q 575 N Q 0.166 Neutral PMS2 P54278 N575R 575 N R 0.166 Neutral PMS2 P54278 N575S 575 N S 0 Neutral PMS2 P54278 N575T 575 N T 0.024 Neutral PMS2 P54278 N575V 575 N V 0.262 Neutral PMS2 P54278 N575W 575 N W 0.446 Neutral PMS2 P54278 N575Y 575 N Y 0.45 Neutral PMS2 P54278 T576A 576 T A 0 Neutral PMS2 P54278 T576C 576 T C 0.03 Neutral PMS2 P54278 T576D 576 T D 0.024 Neutral PMS2 P54278 T576E 576 T E 0.062 Neutral PMS2 P54278 T576F 576 T F 0.214 Neutral PMS2 P54278 T576G 576 T G 0.014 Neutral PMS2 P54278 T576H 576 T H 0.084 Neutral PMS2 P54278 T576I 576 T I 0.042 Neutral PMS2 P54278 T576K 576 T K 0.042 Neutral PMS2 P54278 T576L 576 T L 0.07 Neutral PMS2 P54278 T576M 576 T M 0.048 Neutral PMS2 P54278 T576N 576 T N 0.052 Neutral PMS2 P54278 T576P 576 T P 0.056 Neutral PMS2 P54278 T576Q 576 T Q 0.052 Neutral PMS2 P54278 T576R 576 T R 0.156 Neutral PMS2 P54278 T576S 576 T S 0.024 Neutral PMS2 P54278 T576V 576 T V 0.016 Neutral PMS2 P54278 T576W 576 T W 0.466 Neutral PMS2 P54278 T576Y 576 T Y 0.424 Neutral PMS2 P54278 K577A 577 K A 0.054 Neutral PMS2 P54278 K577C 577 K C 0.028 Neutral PMS2 P54278 K577D 577 K D 0.01 Neutral PMS2 P54278 K577E 577 K E 0.03 Neutral PMS2 P54278 K577F 577 K F 0.234 Neutral PMS2 P54278 K577G 577 K G 0.134 Neutral PMS2 P54278 K577H 577 K H 0.048 Neutral PMS2 P54278 K577I 577 K I 0.248 Neutral PMS2 P54278 K577L 577 K L 0.114 Neutral PMS2 P54278 K577M 577 K M 0.112 Neutral PMS2 P54278 K577N 577 K N 0.05 Neutral PMS2 P54278 K577P 577 K P 0.016 Neutral PMS2 P54278 K577Q 577 K Q 0.09 Neutral PMS2 P54278 K577R 577 K R 0.002 Neutral PMS2 P54278 K577S 577 K S 0.22 Neutral PMS2 P54278 K577T 577 K T 0.182 Neutral PMS2 P54278 K577V 577 K V 0.192 Neutral PMS2 P54278 K577W 577 K W 0.474 Neutral PMS2 P54278 K577Y 577 K Y 0.39 Neutral PMS2 P54278 R578A 578 R A 0.08 Neutral PMS2 P54278 R578C 578 R C 0.008 Neutral PMS2 P54278 R578D 578 R D 0.02 Neutral PMS2 P54278 R578E 578 R E 0.032 Neutral PMS2 P54278 R578F 578 R F 0.306 Neutral PMS2 P54278 R578G 578 R G 0.1 Neutral PMS2 P54278 R578H 578 R H 0.144 Neutral PMS2 P54278 R578I 578 R I 0.326 Neutral PMS2 P54278 R578K 578 R K 0.17 Neutral PMS2 P54278 R578L 578 R L 0.07 Neutral PMS2 P54278 R578M 578 R M 0.174 Neutral PMS2 P54278 R578N 578 R N 0.178 Neutral PMS2 P54278 R578P 578 R P 0.254 Neutral PMS2 P54278 R578Q 578 R Q 0.162 Neutral PMS2 P54278 R578S 578 R S 0.166 Neutral PMS2 P54278 R578T 578 R T 0.144 Neutral PMS2 P54278 R578V 578 R V 0.19 Neutral PMS2 P54278 R578W 578 R W 0.444 Neutral PMS2 P54278 R578Y 578 R Y 0.308 Neutral PMS2 P54278 F579A 579 F A 0.046 Neutral PMS2 P54278 F579C 579 F C 0.072 Neutral PMS2 P54278 F579D 579 F D 0.176 Neutral PMS2 P54278 F579E 579 F E 0.192 Neutral PMS2 P54278 F579G 579 F G 0.138 Neutral PMS2 P54278 F579H 579 F H 0.072 Neutral PMS2 P54278 F579I 579 F I 0.076 Neutral PMS2 P54278 F579K 579 F K 0.186 Neutral PMS2 P54278 F579L 579 F L 0.002 Neutral PMS2 P54278 F579M 579 F M 0.086 Neutral PMS2 P54278 F579N 579 F N 0.178 Neutral PMS2 P54278 F579P 579 F P 0.188 Neutral PMS2 P54278 F579Q 579 F Q 0.172 Neutral PMS2 P54278 F579R 579 F R 0.098 Neutral PMS2 P54278 F579S 579 F S 0.21 Neutral PMS2 P54278 F579T 579 F T 0.224 Neutral PMS2 P54278 F579V 579 F V 0.026 Neutral PMS2 P54278 F579W 579 F W 0.3 Neutral PMS2 P54278 F579Y 579 F Y 0.158 Neutral PMS2 P54278 L58A 58 L A 0.13 Neutral PMS2 P54278 L58C 58 L C 0.116 Neutral PMS2 P54278 L58D 58 L D 0.656 Pathogenic PMS2 P54278 L58E 58 L E 0.61 Pathogenic PMS2 P54278 L58F 58 L F 0.262 Neutral PMS2 P54278 L58G 58 L G 0.576 Pathogenic PMS2 P54278 L58H 58 L H 0.406 Neutral PMS2 P54278 L58I 58 L I 0.342 Neutral PMS2 P54278 L58K 58 L K 0.476 Neutral PMS2 P54278 L58M 58 L M 0.146 Neutral PMS2 P54278 L58N 58 L N 0.604 Pathogenic PMS2 P54278 L58P 58 L P 0.954 Pathogenic PMS2 P54278 L58Q 58 L Q 0.35 Neutral PMS2 P54278 L58R 58 L R 0.866 Pathogenic PMS2 P54278 L58S 58 L S 0.402 Neutral PMS2 P54278 L58T 58 L T 0.382 Neutral PMS2 P54278 L58V 58 L V 0.016 Neutral PMS2 P54278 L58W 58 L W 0.864 Pathogenic PMS2 P54278 L58Y 58 L Y 0.854 Pathogenic PMS2 P54278 K580A 580 K A 0.088 Neutral PMS2 P54278 K580C 580 K C 0.06 Neutral PMS2 P54278 K580D 580 K D 0.1 Neutral PMS2 P54278 K580E 580 K E 0.066 Neutral PMS2 P54278 K580F 580 K F 0.356 Neutral PMS2 P54278 K580G 580 K G 0.182 Neutral PMS2 P54278 K580H 580 K H 0.038 Neutral PMS2 P54278 K580I 580 K I 0.386 Neutral PMS2 P54278 K580L 580 K L 0.292 Neutral PMS2 P54278 K580M 580 K M 0.19 Neutral PMS2 P54278 K580N 580 K N 0.122 Neutral PMS2 P54278 K580P 580 K P 0.378 Neutral PMS2 P54278 K580Q 580 K Q 0.13 Neutral PMS2 P54278 K580R 580 K R 0.01 Neutral PMS2 P54278 K580S 580 K S 0.108 Neutral PMS2 P54278 K580T 580 K T 0.236 Neutral PMS2 P54278 K580V 580 K V 0.292 Neutral PMS2 P54278 K580W 580 K W 0.668 Pathogenic PMS2 P54278 K580Y 580 K Y 0.574 Pathogenic PMS2 P54278 K581A 581 K A 0.054 Neutral PMS2 P54278 K581C 581 K C 0.028 Neutral PMS2 P54278 K581D 581 K D 0.066 Neutral PMS2 P54278 K581E 581 K E 0.03 Neutral PMS2 P54278 K581F 581 K F 0.212 Neutral PMS2 P54278 K581G 581 K G 0.13 Neutral PMS2 P54278 K581H 581 K H 0.048 Neutral PMS2 P54278 K581I 581 K I 0.042 Neutral PMS2 P54278 K581L 581 K L 0.214 Neutral PMS2 P54278 K581M 581 K M 0.078 Neutral PMS2 P54278 K581N 581 K N 0.014 Neutral PMS2 P54278 K581P 581 K P 0.236 Neutral PMS2 P54278 K581Q 581 K Q 0.09 Neutral PMS2 P54278 K581R 581 K R 0.002 Neutral PMS2 P54278 K581S 581 K S 0.014 Neutral PMS2 P54278 K581T 581 K T 0.012 Neutral PMS2 P54278 K581V 581 K V 0.184 Neutral PMS2 P54278 K581W 581 K W 0.396 Neutral PMS2 P54278 K581Y 581 K Y 0.326 Neutral PMS2 P54278 E582A 582 E A 0.066 Neutral PMS2 P54278 E582C 582 E C 0.064 Neutral PMS2 P54278 E582D 582 E D 0.002 Neutral PMS2 P54278 E582F 582 E F 0.28 Neutral PMS2 P54278 E582G 582 E G 0.084 Neutral PMS2 P54278 E582H 582 E H 0.106 Neutral PMS2 P54278 E582I 582 E I 0.332 Neutral PMS2 P54278 E582K 582 E K 0.164 Neutral PMS2 P54278 E582L 582 E L 0.296 Neutral PMS2 P54278 E582M 582 E M 0.172 Neutral PMS2 P54278 E582N 582 E N 0.056 Neutral PMS2 P54278 E582P 582 E P 0.306 Neutral PMS2 P54278 E582Q 582 E Q 0.056 Neutral PMS2 P54278 E582R 582 E R 0.016 Neutral PMS2 P54278 E582S 582 E S 0.158 Neutral PMS2 P54278 E582T 582 E T 0.144 Neutral PMS2 P54278 E582V 582 E V 0.256 Neutral PMS2 P54278 E582W 582 E W 0.448 Neutral PMS2 P54278 E582Y 582 E Y 0.356 Neutral PMS2 P54278 E583A 583 E A 0.144 Neutral PMS2 P54278 E583C 583 E C 0.068 Neutral PMS2 P54278 E583D 583 E D 0 Neutral PMS2 P54278 E583F 583 E F 0.272 Neutral PMS2 P54278 E583G 583 E G 0 Neutral PMS2 P54278 E583H 583 E H 0.162 Neutral PMS2 P54278 E583I 583 E I 0.284 Neutral PMS2 P54278 E583K 583 E K 0.068 Neutral PMS2 P54278 E583L 583 E L 0.286 Neutral PMS2 P54278 E583M 583 E M 0.076 Neutral PMS2 P54278 E583N 583 E N 0.006 Neutral PMS2 P54278 E583P 583 E P 0.3 Neutral PMS2 P54278 E583Q 583 E Q 0.056 Neutral PMS2 P54278 E583R 583 E R 0.036 Neutral PMS2 P54278 E583S 583 E S 0.014 Neutral PMS2 P54278 E583T 583 E T 0.14 Neutral PMS2 P54278 E583V 583 E V 0.142 Neutral PMS2 P54278 E583W 583 E W 0.43 Neutral PMS2 P54278 E583Y 583 E Y 0.338 Neutral PMS2 P54278 I584A 584 I A 0.016 Neutral PMS2 P54278 I584C 584 I C 0.09 Neutral PMS2 P54278 I584D 584 I D 0.166 Neutral PMS2 P54278 I584E 584 I E 0.03 Neutral PMS2 P54278 I584F 584 I F 0.144 Neutral PMS2 P54278 I584G 584 I G 0.23 Neutral PMS2 P54278 I584H 584 I H 0.08 Neutral PMS2 P54278 I584K 584 I K 0.118 Neutral PMS2 P54278 I584L 584 I L 0.108 Neutral PMS2 P54278 I584M 584 I M 0.112 Neutral PMS2 P54278 I584N 584 I N 0.176 Neutral PMS2 P54278 I584P 584 I P 0.172 Neutral PMS2 P54278 I584Q 584 I Q 0.138 Neutral PMS2 P54278 I584R 584 I R 0.248 Neutral PMS2 P54278 I584S 584 I S 0.144 Neutral PMS2 P54278 I584T 584 I T 0.002 Neutral PMS2 P54278 I584V 584 I V 0 Neutral PMS2 P54278 I584W 584 I W 0.344 Neutral PMS2 P54278 I584Y 584 I Y 0.298 Neutral PMS2 P54278 L585A 585 L A 0.008 Neutral PMS2 P54278 L585C 585 L C 0.094 Neutral PMS2 P54278 L585D 585 L D 0.158 Neutral PMS2 P54278 L585E 585 L E 0.106 Neutral PMS2 P54278 L585F 585 L F 0.204 Neutral PMS2 P54278 L585G 585 L G 0.186 Neutral PMS2 P54278 L585H 585 L H 0.04 Neutral PMS2 P54278 L585I 585 L I 0.03 Neutral PMS2 P54278 L585K 585 L K 0.042 Neutral PMS2 P54278 L585M 585 L M 0.08 Neutral PMS2 P54278 L585N 585 L N 0.148 Neutral PMS2 P54278 L585P 585 L P 0.086 Neutral PMS2 P54278 L585Q 585 L Q 0.004 Neutral PMS2 P54278 L585R 585 L R 0.218 Neutral PMS2 P54278 L585S 585 L S 0.01 Neutral PMS2 P54278 L585T 585 L T 0.112 Neutral PMS2 P54278 L585V 585 L V 0.08 Neutral PMS2 P54278 L585W 585 L W 0.334 Neutral PMS2 P54278 L585Y 585 L Y 0.284 Neutral PMS2 P54278 S586A 586 S A 0.01 Neutral PMS2 P54278 S586C 586 S C 0.022 Neutral PMS2 P54278 S586D 586 S D 0.002 Neutral PMS2 P54278 S586E 586 S E 0.114 Neutral PMS2 P54278 S586F 586 S F 0.262 Neutral PMS2 P54278 S586G 586 S G 0.036 Neutral PMS2 P54278 S586H 586 S H 0.238 Neutral PMS2 P54278 S586I 586 S I 0.124 Neutral PMS2 P54278 S586K 586 S K 0.146 Neutral PMS2 P54278 S586L 586 S L 0.026 Neutral PMS2 P54278 S586M 586 S M 0.332 Neutral PMS2 P54278 S586N 586 S N 0.034 Neutral PMS2 P54278 S586P 586 S P 0.132 Neutral PMS2 P54278 S586Q 586 S Q 0.158 Neutral PMS2 P54278 S586R 586 S R 0.248 Neutral PMS2 P54278 S586T 586 S T 0.176 Neutral PMS2 P54278 S586V 586 S V 0.034 Neutral PMS2 P54278 S586W 586 S W 0.49 Neutral PMS2 P54278 S586Y 586 S Y 0.448 Neutral PMS2 P54278 S587A 587 S A 0.052 Neutral PMS2 P54278 S587C 587 S C 0.022 Neutral PMS2 P54278 S587D 587 S D 0.004 Neutral PMS2 P54278 S587E 587 S E 0.124 Neutral PMS2 P54278 S587F 587 S F 0.276 Neutral PMS2 P54278 S587G 587 S G 0.066 Neutral PMS2 P54278 S587H 587 S H 0.238 Neutral PMS2 P54278 S587I 587 S I 0.196 Neutral PMS2 P54278 S587K 587 S K 0.148 Neutral PMS2 P54278 S587L 587 S L 0.068 Neutral PMS2 P54278 S587M 587 S M 0.332 Neutral PMS2 P54278 S587N 587 S N 0.004 Neutral PMS2 P54278 S587P 587 S P 0.132 Neutral PMS2 P54278 S587Q 587 S Q 0.132 Neutral PMS2 P54278 S587R 587 S R 0.17 Neutral PMS2 P54278 S587T 587 S T 0.104 Neutral PMS2 P54278 S587V 587 S V 0.288 Neutral PMS2 P54278 S587W 587 S W 0.49 Neutral PMS2 P54278 S587Y 587 S Y 0.448 Neutral PMS2 P54278 S588A 588 S A 0.01 Neutral PMS2 P54278 S588C 588 S C 0.022 Neutral PMS2 P54278 S588D 588 S D 0.044 Neutral PMS2 P54278 S588E 588 S E 0.122 Neutral PMS2 P54278 S588F 588 S F 0.266 Neutral PMS2 P54278 S588G 588 S G 0.036 Neutral PMS2 P54278 S588H 588 S H 0.238 Neutral PMS2 P54278 S588I 588 S I 0.196 Neutral PMS2 P54278 S588K 588 S K 0.164 Neutral PMS2 P54278 S588L 588 S L 0.028 Neutral PMS2 P54278 S588M 588 S M 0.332 Neutral PMS2 P54278 S588N 588 S N 0.034 Neutral PMS2 P54278 S588P 588 S P 0.056 Neutral PMS2 P54278 S588Q 588 S Q 0.16 Neutral PMS2 P54278 S588R 588 S R 0.152 Neutral PMS2 P54278 S588T 588 S T 0.02 Neutral PMS2 P54278 S588V 588 S V 0.134 Neutral PMS2 P54278 S588W 588 S W 0.472 Neutral PMS2 P54278 S588Y 588 S Y 0.448 Neutral PMS2 P54278 D589A 589 D A 0.082 Neutral PMS2 P54278 D589C 589 D C 0.148 Neutral PMS2 P54278 D589E 589 D E 0.038 Neutral PMS2 P54278 D589F 589 D F 0.174 Neutral PMS2 P54278 D589G 589 D G 0.018 Neutral PMS2 P54278 D589H 589 D H 0.09 Neutral PMS2 P54278 D589I 589 D I 0.262 Neutral PMS2 P54278 D589K 589 D K 0.112 Neutral PMS2 P54278 D589L 589 D L 0.026 Neutral PMS2 P54278 D589M 589 D M 0.19 Neutral PMS2 P54278 D589N 589 D N 0 Neutral PMS2 P54278 D589P 589 D P 0.144 Neutral PMS2 P54278 D589Q 589 D Q 0.172 Neutral PMS2 P54278 D589R 589 D R 0.128 Neutral PMS2 P54278 D589S 589 D S 0.002 Neutral PMS2 P54278 D589T 589 D T 0.154 Neutral PMS2 P54278 D589V 589 D V 0.262 Neutral PMS2 P54278 D589W 589 D W 0.434 Neutral PMS2 P54278 D589Y 589 D Y 0.432 Neutral PMS2 P54278 K59A 59 K A 0.256 Neutral PMS2 P54278 K59C 59 K C 0.208 Neutral PMS2 P54278 K59D 59 K D 0.326 Neutral PMS2 P54278 K59E 59 K E 0.156 Neutral PMS2 P54278 K59F 59 K F 0.852 Pathogenic PMS2 P54278 K59G 59 K G 0.36 Neutral PMS2 P54278 K59H 59 K H 0.414 Neutral PMS2 P54278 K59I 59 K I 0.126 Neutral PMS2 P54278 K59L 59 K L 0.862 Pathogenic PMS2 P54278 K59M 59 K M 0.656 Pathogenic PMS2 P54278 K59N 59 K N 0.368 Neutral PMS2 P54278 K59P 59 K P 0.83 Pathogenic PMS2 P54278 K59Q 59 K Q 0.166 Neutral PMS2 P54278 K59R 59 K R 0.036 Neutral PMS2 P54278 K59S 59 K S 0.394 Neutral PMS2 P54278 K59T 59 K T 0.03 Neutral PMS2 P54278 K59V 59 K V 0.628 Pathogenic PMS2 P54278 K59W 59 K W 0.97 Pathogenic PMS2 P54278 K59Y 59 K Y 0.928 Pathogenic PMS2 P54278 I590A 590 I A 0.006 Neutral PMS2 P54278 I590C 590 I C 0.09 Neutral PMS2 P54278 I590D 590 I D 0.166 Neutral PMS2 P54278 I590E 590 I E 0.038 Neutral PMS2 P54278 I590F 590 I F 0.206 Neutral PMS2 P54278 I590G 590 I G 0.206 Neutral PMS2 P54278 I590H 590 I H 0.08 Neutral PMS2 P54278 I590K 590 I K 0.042 Neutral PMS2 P54278 I590L 590 I L 0 Neutral PMS2 P54278 I590M 590 I M 0.112 Neutral PMS2 P54278 I590N 590 I N 0.176 Neutral PMS2 P54278 I590P 590 I P 0.096 Neutral PMS2 P54278 I590Q 590 I Q 0.198 Neutral PMS2 P54278 I590R 590 I R 0.244 Neutral PMS2 P54278 I590S 590 I S 0.144 Neutral PMS2 P54278 I590T 590 I T 0.192 Neutral PMS2 P54278 I590V 590 I V 0 Neutral PMS2 P54278 I590W 590 I W 0.344 Neutral PMS2 P54278 I590Y 590 I Y 0.298 Neutral PMS2 P54278 C591A 591 C A 0.004 Neutral PMS2 P54278 C591D 591 C D 0.026 Neutral PMS2 P54278 C591E 591 C E 0.18 Neutral PMS2 P54278 C591F 591 C F 0.406 Neutral PMS2 P54278 C591G 591 C G 0.05 Neutral PMS2 P54278 C591H 591 C H 0.22 Neutral PMS2 P54278 C591I 591 C I 0.27 Neutral PMS2 P54278 C591K 591 C K 0.208 Neutral PMS2 P54278 C591L 591 C L 0.038 Neutral PMS2 P54278 C591M 591 C M 0.136 Neutral PMS2 P54278 C591N 591 C N 0.018 Neutral PMS2 P54278 C591P 591 C P 0.024 Neutral PMS2 P54278 C591Q 591 C Q 0.03 Neutral PMS2 P54278 C591R 591 C R 0.222 Neutral PMS2 P54278 C591S 591 C S 0.014 Neutral PMS2 P54278 C591T 591 C T 0.108 Neutral PMS2 P54278 C591V 591 C V 0.186 Neutral PMS2 P54278 C591W 591 C W 0.482 Neutral PMS2 P54278 C591Y 591 C Y 0.444 Neutral PMS2 P54278 Q592A 592 Q A 0.036 Neutral PMS2 P54278 Q592C 592 Q C 0.082 Neutral PMS2 P54278 Q592D 592 Q D 0.046 Neutral PMS2 P54278 Q592E 592 Q E 0.068 Neutral PMS2 P54278 Q592F 592 Q F 0.26 Neutral PMS2 P54278 Q592G 592 Q G 0.036 Neutral PMS2 P54278 Q592H 592 Q H 0.076 Neutral PMS2 P54278 Q592I 592 Q I 0.278 Neutral PMS2 P54278 Q592K 592 Q K 0.21 Neutral PMS2 P54278 Q592L 592 Q L 0.214 Neutral PMS2 P54278 Q592M 592 Q M 0.186 Neutral PMS2 P54278 Q592N 592 Q N 0.094 Neutral PMS2 P54278 Q592P 592 Q P 0.218 Neutral PMS2 P54278 Q592R 592 Q R 0.002 Neutral PMS2 P54278 Q592S 592 Q S 0.112 Neutral PMS2 P54278 Q592T 592 Q T 0.064 Neutral PMS2 P54278 Q592V 592 Q V 0.092 Neutral PMS2 P54278 Q592W 592 Q W 0.42 Neutral PMS2 P54278 Q592Y 592 Q Y 0.452 Neutral PMS2 P54278 K593A 593 K A 0.056 Neutral PMS2 P54278 K593C 593 K C 0.028 Neutral PMS2 P54278 K593D 593 K D 0.05 Neutral PMS2 P54278 K593E 593 K E 0.004 Neutral PMS2 P54278 K593F 593 K F 0.212 Neutral PMS2 P54278 K593G 593 K G 0.042 Neutral PMS2 P54278 K593H 593 K H 0.018 Neutral PMS2 P54278 K593I 593 K I 0.124 Neutral PMS2 P54278 K593L 593 K L 0.148 Neutral PMS2 P54278 K593M 593 K M 0.106 Neutral PMS2 P54278 K593N 593 K N 0.082 Neutral PMS2 P54278 K593P 593 K P 0.236 Neutral PMS2 P54278 K593Q 593 K Q 0.09 Neutral PMS2 P54278 K593R 593 K R 0.002 Neutral PMS2 P54278 K593S 593 K S 0.012 Neutral PMS2 P54278 K593T 593 K T 0.028 Neutral PMS2 P54278 K593V 593 K V 0.184 Neutral PMS2 P54278 K593W 593 K W 0.396 Neutral PMS2 P54278 K593Y 593 K Y 0.326 Neutral PMS2 P54278 L594A 594 L A 0.022 Neutral PMS2 P54278 L594C 594 L C 0.006 Neutral PMS2 P54278 L594D 594 L D 0.038 Neutral PMS2 P54278 L594E 594 L E 0.106 Neutral PMS2 P54278 L594F 594 L F 0.204 Neutral PMS2 P54278 L594G 594 L G 0.186 Neutral PMS2 P54278 L594H 594 L H 0.022 Neutral PMS2 P54278 L594I 594 L I 0.072 Neutral PMS2 P54278 L594K 594 L K 0.178 Neutral PMS2 P54278 L594M 594 L M 0.18 Neutral PMS2 P54278 L594N 594 L N 0.138 Neutral PMS2 P54278 L594P 594 L P 0.24 Neutral PMS2 P54278 L594Q 594 L Q 0.048 Neutral PMS2 P54278 L594R 594 L R 0.218 Neutral PMS2 P54278 L594S 594 L S 0.01 Neutral PMS2 P54278 L594T 594 L T 0.112 Neutral PMS2 P54278 L594V 594 L V 0 Neutral PMS2 P54278 L594W 594 L W 0.334 Neutral PMS2 P54278 L594Y 594 L Y 0.282 Neutral PMS2 P54278 V595A 595 V A 0.054 Neutral PMS2 P54278 V595C 595 V C 0.056 Neutral PMS2 P54278 V595D 595 V D 0.122 Neutral PMS2 P54278 V595E 595 V E 0.158 Neutral PMS2 P54278 V595F 595 V F 0.142 Neutral PMS2 P54278 V595G 595 V G 0.196 Neutral PMS2 P54278 V595H 595 V H 0.068 Neutral PMS2 P54278 V595I 595 V I 0.028 Neutral PMS2 P54278 V595K 595 V K 0.158 Neutral PMS2 P54278 V595L 595 V L 0 Neutral PMS2 P54278 V595M 595 V M 0.012 Neutral PMS2 P54278 V595N 595 V N 0.144 Neutral PMS2 P54278 V595P 595 V P 0.036 Neutral PMS2 P54278 V595Q 595 V Q 0.1 Neutral PMS2 P54278 V595R 595 V R 0.21 Neutral PMS2 P54278 V595S 595 V S 0.064 Neutral PMS2 P54278 V595T 595 V T 0.058 Neutral PMS2 P54278 V595W 595 V W 0.344 Neutral PMS2 P54278 V595Y 595 V Y 0.256 Neutral PMS2 P54278 N596A 596 N A 0.07 Neutral PMS2 P54278 N596C 596 N C 0.158 Neutral PMS2 P54278 N596D 596 N D 0.008 Neutral PMS2 P54278 N596E 596 N E 0.014 Neutral PMS2 P54278 N596F 596 N F 0.34 Neutral PMS2 P54278 N596G 596 N G 0.044 Neutral PMS2 P54278 N596H 596 N H 0.23 Neutral PMS2 P54278 N596I 596 N I 0.264 Neutral PMS2 P54278 N596K 596 N K 0.038 Neutral PMS2 P54278 N596L 596 N L 0.272 Neutral PMS2 P54278 N596M 596 N M 0.22 Neutral PMS2 P54278 N596P 596 N P 0.248 Neutral PMS2 P54278 N596Q 596 N Q 0.166 Neutral PMS2 P54278 N596R 596 N R 0.148 Neutral PMS2 P54278 N596S 596 N S 0.02 Neutral PMS2 P54278 N596T 596 N T 0.006 Neutral PMS2 P54278 N596V 596 N V 0.28 Neutral PMS2 P54278 N596W 596 N W 0.446 Neutral PMS2 P54278 N596Y 596 N Y 0.402 Neutral PMS2 P54278 T597A 597 T A 0 Neutral PMS2 P54278 T597C 597 T C 0.064 Neutral PMS2 P54278 T597D 597 T D 0.046 Neutral PMS2 P54278 T597E 597 T E 0.062 Neutral PMS2 P54278 T597F 597 T F 0.214 Neutral PMS2 P54278 T597G 597 T G 0.058 Neutral PMS2 P54278 T597H 597 T H 0.084 Neutral PMS2 P54278 T597I 597 T I 0.076 Neutral PMS2 P54278 T597K 597 T K 0.042 Neutral PMS2 P54278 T597L 597 T L 0.008 Neutral PMS2 P54278 T597M 597 T M 0.032 Neutral PMS2 P54278 T597N 597 T N 0.052 Neutral PMS2 P54278 T597P 597 T P 0.01 Neutral PMS2 P54278 T597Q 597 T Q 0.016 Neutral PMS2 P54278 T597R 597 T R 0.26 Neutral PMS2 P54278 T597S 597 T S 0 Neutral 2 PMS2 P54278 T597V 597 T V 0.016 Neutral PMS2 P54278 T597W 597 T W 0.466 Neutral PMS2 P54278 T597Y 597 T Y 0.424 Neutral PMS2 P54278 Q598A 598 Q A 0.138 Neutral PMS2 P54278 Q598C 598 Q C 0.082 Neutral PMS2 P54278 Q598D 598 Q D 0.088 Neutral PMS2 P54278 Q598E 598 Q E 0.008 Neutral PMS2 P54278 Q598F 598 Q F 0.26 Neutral PMS2 P54278 Q598G 598 Q G 0.116 Neutral PMS2 P54278 Q598H 598 Q H 0.262 Neutral PMS2 P54278 Q598I 598 Q I 0.278 Neutral PMS2 P54278 Q598K 598 Q K 0.02 Neutral PMS2 P54278 Q598L 598 Q L 0.214 Neutral PMS2 P54278 Q598M 598 Q M 0.186 Neutral PMS2 P54278 Q598N 598 Q N 0.094 Neutral PMS2 P54278 Q598P 598 Q P 0.22 Neutral PMS2 P54278 Q598R 598 Q R 0.002 Neutral PMS2 P54278 Q598S 598 Q S 0.176 Neutral PMS2 P54278 Q598T 598 Q T 0.064 Neutral PMS2 P54278 Q598V 598 Q V 0.26 Neutral PMS2 P54278 Q598W 598 Q W 0.42 Neutral PMS2 P54278 Q598Y 598 Q Y 0.362 Neutral PMS2 P54278 D599A 599 D A 0.072 Neutral PMS2 P54278 D599C 599 D C 0.148 Neutral PMS2 P54278 D599E 599 D E 0.162 Neutral PMS2 P54278 D599F 599 D F 0.37 Neutral PMS2 P54278 D599G 599 D G 0.082 Neutral PMS2 P54278 D599H 599 D H 0.09 Neutral PMS2 P54278 D599I 599 D I 0.262 Neutral PMS2 P54278 D599K 599 D K 0.21 Neutral PMS2 P54278 D599L 599 D L 0.262 Neutral PMS2 P54278 D599M 599 D M 0.19 Neutral PMS2 P54278 D599N 599 D N 0 Neutral PMS2 P54278 D599P 599 D P 0.144 Neutral PMS2 P54278 D599Q 599 D Q 0.078 Neutral PMS2 P54278 D599R 599 D R 0.152 Neutral PMS2 P54278 D599S 599 D S 0.002 Neutral PMS2 P54278 D599T 599 D T 0.1 Neutral PMS2 P54278 D599V 599 D V 0.262 Neutral PMS2 P54278 D599W 599 D W 0.434 Neutral PMS2 P54278 D599Y 599 D Y 0.404 Neutral PMS2 P54278 S6A 6 S A 0.01 Neutral PMS2 P54278 S6C 6 S C 0.032 Neutral PMS2 P54278 S6D 6 S D 0.002 Neutral PMS2 P54278 S6E 6 S E 0.138 Neutral PMS2 P54278 S6F 6 S F 0.276 Neutral PMS2 P54278 S6G 6 S G 0 Neutral PMS2 P54278 S6H 6 S H 0.238 Neutral PMS2 P54278 S6I 6 S I 0.196 Neutral PMS2 P54278 S6K 6 S K 0.146 Neutral PMS2 P54278 S6L 6 S L 0.032 Neutral PMS2 P54278 S6M 6 S M 0.272 Neutral PMS2 P54278 S6N 6 S N 0.018 Neutral PMS2 P54278 S6P 6 S P 0.116 Neutral PMS2 P54278 S6Q 6 S Q 0.16 Neutral PMS2 P54278 S6R 6 S R 0.138 Neutral PMS2 P54278 S6T 6 S T 0.046 Neutral PMS2 P54278 S6V 6 S V 0.034 Neutral PMS2 P54278 S6W 6 S W 0.472 Neutral PMS2 P54278 S6Y 6 S Y 0.434 Neutral PMS2 P54278 D60A 60 D A 0.17 Neutral PMS2 P54278 D60C 60 D C 0.68 Pathogenic PMS2 P54278 D60E 60 D E 0.032 Neutral 2 PMS2 P54278 D60F 60 D F 0.894 Pathogenic PMS2 P54278 D60G 60 D G 0.26 Neutral PMS2 P54278 D60H 60 D H 0.41 Neutral PMS2 P54278 D60I 60 D I 0.854 Pathogenic PMS2 P54278 D60K 60 D K 0.42 Neutral PMS2 P54278 D60L 60 D L 0.844 Pathogenic PMS2 P54278 D60M 60 D M 0.76 Pathogenic PMS2 P54278 D60N 60 D N 0.026 Neutral PMS2 P54278 D60P 60 D P 0.784 Pathogenic PMS2 P54278 D60Q 60 D Q 0.214 Neutral PMS2 P54278 D60R 60 D R 0.686 Pathogenic PMS2 P54278 D60S 60 D S 0.036 Neutral PMS2 P54278 D60T 60 D T 0.52 Pathogenic PMS2 P54278 D60V 60 D V 0.88 Pathogenic PMS2 P54278 D60W 60 D W 0.95 Pathogenic PMS2 P54278 D60Y 60 D Y 0.944 Pathogenic PMS2 P54278 M600A 600 M A 0.046 Neutral PMS2 P54278 M600C 600 M C 0.042 Neutral PMS2 P54278 M600D 600 M D 0.14 Neutral PMS2 P54278 M600E 600 M E 0.034 Neutral PMS2 P54278 M600F 600 M F 0.26 Neutral PMS2 P54278 M600G 600 M G 0.136 Neutral PMS2 P54278 M600H 600 M H 0.058 Neutral PMS2 P54278 M600I 600 M I 0.076 Neutral PMS2 P54278 M600K 600 M K 0.06 Neutral PMS2 P54278 M600L 600 M L 0.09 Neutral PMS2 P54278 M600N 600 M N 0.18 Neutral PMS2 P54278 M600P 600 M P 0.214 Neutral PMS2 P54278 M600Q 600 M Q 0.024 Neutral PMS2 P54278 M600R 600 M R 0.084 Neutral PMS2 P54278 M600S 600 M S 0.008 Neutral PMS2 P54278 M600T 600 M T 0.008 Neutral PMS2 P54278 M600V 600 M V 0.016 Neutral PMS2 P54278 M600W 600 M W 0.422 Neutral PMS2 P54278 M600Y 600 M Y 0.348 Neutral PMS2 P54278 S601A 601 S A 0.01 Neutral PMS2 P54278 S601C 601 S C 0.022 Neutral PMS2 P54278 S601D 601 S D 0.044 Neutral PMS2 P54278 S601E 601 S E 0.124 Neutral PMS2 P54278 S601F 601 S F 0.266 Neutral PMS2 P54278 S601G 601 S G 0.01 Neutral PMS2 P54278 S601H 601 S H 0.238 Neutral PMS2 P54278 S601I 601 S I 0.026 Neutral PMS2 P54278 S601K 601 S K 0.14 Neutral PMS2 P54278 S601L 601 S L 0.062 Neutral PMS2 P54278 S601M 601 S M 0.248 Neutral PMS2 P54278 S601N 601 S N 0.034 Neutral PMS2 P54278 S601P 601 S P 0.062 Neutral PMS2 P54278 S601Q 601 S Q 0.158 Neutral PMS2 P54278 S601R 601 S R 0.152 Neutral PMS2 P54278 S601T 601 S T 0.046 Neutral PMS2 P54278 S601V 601 S V 0.068 Neutral PMS2 P54278 S601W 601 S W 0.49 Neutral PMS2 P54278 S601Y 601 S Y 0.448 Neutral PMS2 P54278 A602C 602 A C 0.182 Neutral PMS2 P54278 A602D 602 A D 0.316 Neutral PMS2 P54278 A602E 602 A E 0.302 Neutral PMS2 P54278 A602F 602 A F 0.468 Neutral PMS2 P54278 A602G 602 A G 0.154 Neutral PMS2 P54278 A602H 602 A H 0.304 Neutral PMS2 P54278 A602I 602 A I 0.446 Neutral PMS2 P54278 A602K 602 A K 0.354 Neutral PMS2 P54278 A602L 602 A L 0.354 Neutral PMS2 P54278 A602M 602 A M 0.256 Neutral PMS2 P54278 A602N 602 A N 0.274 Neutral PMS2 P54278 A602P 602 A P 0.038 Neutral PMS2 P54278 A602Q 602 A Q 0.286 Neutral PMS2 P54278 A602R 602 A R 0.326 Neutral PMS2 P54278 A602S 602 A S 0.006 Neutral PMS2 P54278 A602T 602 A T 0.172 Neutral PMS2 P54278 A602V 602 A V 0.042 Neutral PMS2 P54278 A602W 602 A W 0.484 Neutral PMS2 P54278 A602Y 602 A Y 0.5 Pathogenic PMS2 P54278 S603A 603 S A 0.01 Neutral PMS2 P54278 S603C 603 S C 0.022 Neutral PMS2 P54278 S603D 603 S D 0.024 Neutral PMS2 P54278 S603E 603 S E 0.122 Neutral PMS2 P54278 S603F 603 S F 0.266 Neutral PMS2 P54278 S603G 603 S G 0.036 Neutral PMS2 P54278 S603H 603 S H 0.188 Neutral PMS2 P54278 S603I 603 S I 0.026 Neutral PMS2 P54278 S603K 603 S K 0.164 Neutral PMS2 P54278 S603L 603 S L 0.042 Neutral PMS2 P54278 S603M 603 S M 0.332 Neutral PMS2 P54278 S603N 603 S N 0.004 Neutral PMS2 P54278 S603P 603 S P 0.132 Neutral PMS2 P54278 S603Q 603 S Q 0.16 Neutral PMS2 P54278 S603R 603 S R 0.17 Neutral PMS2 P54278 S603T 603 S T 0.02 Neutral PMS2 P54278 S603V 603 S V 0.034 Neutral PMS2 P54278 S603W 603 S W 0.49 Neutral PMS2 P54278 S603Y 603 S Y 0.448 Neutral PMS2 P54278 Q604A 604 Q A 0.1 Neutral PMS2 P54278 Q604C 604 Q C 0.082 Neutral PMS2 P54278 Q604D 604 Q D 0.088 Neutral PMS2 P54278 Q604E 604 Q E 0.008 Neutral PMS2 P54278 Q604F 604 Q F 0.26 Neutral PMS2 P54278 Q604G 604 Q G 0.116 Neutral PMS2 P54278 Q604H 604 Q H 0.034 Neutral PMS2 P54278 Q604I 604 Q I 0.274 Neutral PMS2 P54278 Q604K 604 Q K 0.21 Neutral PMS2 P54278 Q604L 604 Q L 0.12 Neutral PMS2 P54278 Q604M 604 Q M 0.186 Neutral PMS2 P54278 Q604N 604 Q N 0.094 Neutral PMS2 P54278 Q604P 604 Q P 0.294 Neutral PMS2 P54278 Q604R 604 Q R 0.04 Neutral PMS2 P54278 Q604S 604 Q S 0.036 Neutral PMS2 P54278 Q604T 604 Q T 0.014 Neutral PMS2 P54278 Q604V 604 Q V 0.268 Neutral PMS2 P54278 Q604W 604 Q W 0.42 Neutral PMS2 P54278 Q604Y 604 Q Y 0.362 Neutral PMS2 P54278 V605A 605 V A 0.054 Neutral PMS2 P54278 V605C 605 V C 0.058 Neutral PMS2 P54278 V605D 605 V D 0.032 Neutral PMS2 P54278 V605E 605 V E 0.228 Neutral PMS2 P54278 V605F 605 V F 0.192 Neutral PMS2 P54278 V605G 605 V G 0.202 Neutral PMS2 P54278 V605H 605 V H 0.086 Neutral PMS2 P54278 V605I 605 V I 0.028 Neutral PMS2 P54278 V605K 605 V K 0.172 Neutral PMS2 P54278 V605L 605 V L 0.018 Neutral PMS2 P54278 V605M 605 V M 0.088 Neutral PMS2 P54278 V605N 605 V N 0.094 Neutral PMS2 P54278 V605P 605 V P 0.206 Neutral PMS2 P54278 V605Q 605 V Q 0.244 Neutral PMS2 P54278 V605R 605 V R 0.26 Neutral PMS2 P54278 V605S 605 V S 0.026 Neutral PMS2 P54278 V605T 605 V T 0.058 Neutral PMS2 P54278 V605W 605 V W 0.372 Neutral PMS2 P54278 V605Y 605 V Y 0.208 Neutral PMS2 P54278 D606A 606 D A 0.132 Neutral PMS2 P54278 D606C 606 D C 0.24 Neutral PMS2 P54278 D606E 606 D E 0.188 Neutral PMS2 P54278 D606F 606 D F 0.588 Pathogenic PMS2 P54278 D606G 606 D G 0.214 Neutral PMS2 P54278 D606H 606 D H 0.154 Neutral PMS2 P54278 D606I 606 D I 0.446 Neutral PMS2 P54278 D606K 606 D K 0.022 Neutral PMS2 P54278 D606L 606 D L 0.4 Neutral PMS2 P54278 D606M 606 D M 0.31 Neutral PMS2 P54278 D606N 606 D N 0.032 Neutral PMS2 P54278 D606P 606 D P 0.192 Neutral PMS2 P54278 D606Q 606 D Q 0.168 Neutral PMS2 P54278 D606R 606 D R 0.248 Neutral PMS2 P54278 D606S 606 D S 0.084 Neutral PMS2 P54278 D606T 606 D T 0.224 Neutral PMS2 P54278 D606V 606 D V 0.398 Neutral PMS2 P54278 D606W 606 D W 0.67 Pathogenic PMS2 P54278 D606Y 606 D Y 0.644 Pathogenic PMS2 P54278 V607A 607 V A 0 Neutral PMS2 P54278 V607C 607 V C 0.064 Neutral PMS2 P54278 V607D 607 V D 0.14 Neutral PMS2 P54278 V607E 607 V E 0.202 Neutral PMS2 P54278 V607F 607 V F 0.222 Neutral PMS2 P54278 V607G 607 V G 0.12 Neutral PMS2 P54278 V607H 607 V H 0.146 Neutral PMS2 P54278 V607I 607 V I 0.008 Neutral PMS2 P54278 V607K 607 V K 0.186 Neutral PMS2 P54278 V607L 607 V L 0.02 Neutral PMS2 P54278 V607M 607 V M 0.104 Neutral PMS2 P54278 V607N 607 V N 0.152 Neutral PMS2 P54278 V607P 607 V P 0.16 Neutral PMS2 P54278 V607Q 607 V Q 0.26 Neutral PMS2 P54278 V607R 607 V R 0.28 Neutral PMS2 P54278 V607S 607 V S 0.012 Neutral PMS2 P54278 V607T 607 V T 0.094 Neutral PMS2 P54278 V607W 607 V W 0.4 Neutral PMS2 P54278 V607Y 607 V Y 0.312 Neutral PMS2 P54278 A608C 608 A C 0.182 Neutral PMS2 P54278 A608D 608 A D 0.35 Neutral PMS2 P54278 A608E 608 A E 0.302 Neutral PMS2 P54278 A608F 608 A F 0.468 Neutral PMS2 P54278 A608G 608 A G 0.074 Neutral PMS2 P54278 A608H 608 A H 0.304 Neutral PMS2 P54278 A608I 608 A I 0.406 Neutral PMS2 P54278 A608K 608 A K 0.354 Neutral PMS2 P54278 A608L 608 A L 0.318 Neutral PMS2 P54278 A608M 608 A M 0.29 Neutral PMS2 P54278 A608N 608 A N 0.296 Neutral PMS2 P54278 A608P 608 A P 0.038 Neutral PMS2 P54278 A608Q 608 A Q 0.302 Neutral PMS2 P54278 A608R 608 A R 0.318 Neutral PMS2 P54278 A608S 608 A S 0.008 Neutral PMS2 P54278 A608T 608 A T 0.08 Neutral PMS2 P54278 A608V 608 A V 0.202 Neutral PMS2 P54278 A608W 608 A W 0.504 Pathogenic PMS2 P54278 A608Y 608 A Y 0.5 Pathogenic PMS2 P54278 V609A 609 V A 0.052 Neutral PMS2 P54278 V609C 609 V C 0.058 Neutral PMS2 P54278 V609D 609 V D 0.13 Neutral PMS2 P54278 V609E 609 V E 0.214 Neutral PMS2 P54278 V609F 609 V F 0.176 Neutral PMS2 P54278 V609G 609 V G 0.18 Neutral PMS2 P54278 V609H 609 V H 0.116 Neutral PMS2 P54278 V609I 609 V I 0.002 Neutral PMS2 P54278 V609K 609 V K 0.158 Neutral PMS2 P54278 V609L 609 V L 0 Neutral PMS2 P54278 V609M 609 V M 0.04 Neutral PMS2 P54278 V609N 609 V N 0.09 Neutral PMS2 P54278 V609P 609 V P 0.094 Neutral PMS2 P54278 V609Q 609 V Q 0.106 Neutral PMS2 P54278 V609R 609 V R 0.288 Neutral PMS2 P54278 V609S 609 V S 0.07 Neutral PMS2 P54278 V609T 609 V T 0.094 Neutral PMS2 P54278 V609W 609 V W 0.348 Neutral PMS2 P54278 V609Y 609 V Y 0.26 Neutral PMS2 P54278 Y61A 61 Y A 0.224 Neutral PMS2 P54278 Y61C 61 Y C 0.16 Neutral PMS2 P54278 Y61D 61 Y D 0.542 Pathogenic PMS2 P54278 Y61E 61 Y E 0.536 Pathogenic PMS2 P54278 Y61F 61 Y F 0.04 Neutral PMS2 P54278 Y61G 61 Y G 0.262 Neutral PMS2 P54278 Y61H 61 Y H 0.042 Neutral PMS2 P54278 Y61I 61 Y I 0.43 Neutral PMS2 P54278 Y61K 61 Y K 0.514 Pathogenic PMS2 P54278 Y61L 61 Y L 0.254 Neutral PMS2 P54278 Y61M 61 Y M 0.254 Neutral PMS2 P54278 Y61N 61 Y N 0.14 Neutral PMS2 P54278 Y61P 61 Y P 0.35 Neutral PMS2 P54278 Y61Q 61 Y Q 0.118 Neutral PMS2 P54278 Y61R 61 Y R 0.538 Pathogenic PMS2 P54278 Y61S 61 Y S 0.244 Neutral PMS2 P54278 Y61T 61 Y T 0.312 Neutral PMS2 P54278 Y61V 61 Y V 0.398 Neutral PMS2 P54278 Y61W 61 Y W 0.406 Neutral PMS2 P54278 K610A 610 K A 0.028 Neutral PMS2 P54278 K610C 610 K C 0.028 Neutral PMS2 P54278 K610D 610 K D 0.05 Neutral PMS2 P54278 K610E 610 K E 0.004 Neutral PMS2 P54278 K610F 610 K F 0.23 Neutral PMS2 P54278 K610G 610 K G 0.132 Neutral PMS2 P54278 K610H 610 K H 0.01 Neutral PMS2 P54278 K610I 610 K I 0.222 Neutral PMS2 P54278 K610L 610 K L 0.214 Neutral PMS2 P54278 K610M 610 K M 0.106 Neutral PMS2 P54278 K610N 610 K N 0.046 Neutral PMS2 P54278 K610P 610 K P 0.214 Neutral PMS2 P54278 K610Q 610 K Q 0.09 Neutral PMS2 P54278 K610R 610 K R 0.016 Neutral PMS2 P54278 K610S 610 K S 0.22 Neutral PMS2 P54278 K610T 610 K T 0.092 Neutral PMS2 P54278 K610V 610 K V 0.18 Neutral PMS2 P54278 K610W 610 K W 0.396 Neutral PMS2 P54278 K610Y 610 K Y 0.326 Neutral PMS2 P54278 I611A 611 I A 0.006 Neutral PMS2 P54278 I611C 611 I C 0.092 Neutral PMS2 P54278 I611D 611 I D 0.046 Neutral PMS2 P54278 I611E 611 I E 0.148 Neutral PMS2 P54278 I611F 611 I F 0.246 Neutral PMS2 P54278 I611G 611 I G 0.212 Neutral PMS2 P54278 I611H 611 I H 0.086 Neutral PMS2 P54278 I611K 611 I K 0.16 Neutral PMS2 P54278 I611L 611 I L 0.11 Neutral PMS2 P54278 I611M 611 I M 0.168 Neutral PMS2 P54278 I611N 611 I N 0.242 Neutral PMS2 P54278 I611P 611 I P 0.186 Neutral PMS2 P54278 I611Q 611 I Q 0.186 Neutral PMS2 P54278 I611R 611 I R 0.316 Neutral PMS2 P54278 I611S 611 I S 0.162 Neutral PMS2 P54278 I611T 611 I T 0.192 Neutral PMS2 P54278 I611V 611 I V 0 Neutral PMS2 P54278 I611W 611 I W 0.392 Neutral PMS2 P54278 I611Y 611 I Y 0.346 Neutral PMS2 P54278 N612A 612 N A 0.004 Neutral PMS2 P54278 N612C 612 N C 0.148 Neutral PMS2 P54278 N612D 612 N D 0.008 Neutral PMS2 P54278 N612E 612 N E 0.086 Neutral PMS2 P54278 N612F 612 N F 0.34 Neutral PMS2 P54278 N612G 612 N G 0.162 Neutral PMS2 P54278 N612H 612 N H 0.024 Neutral PMS2 P54278 N612I 612 N I 0.336 Neutral PMS2 P54278 N612K 612 N K 0.038 Neutral PMS2 P54278 N612L 612 N L 0.272 Neutral PMS2 P54278 N612M 612 N M 0.22 Neutral PMS2 P54278 N612P 612 N P 0.338 Neutral PMS2 P54278 N612Q 612 N Q 0.014 Neutral PMS2 P54278 N612R 612 N R 0.148 Neutral PMS2 P54278 N612S 612 N S 0 Neutral PMS2 P54278 N612T 612 N T 0.142 Neutral PMS2 P54278 N612V 612 N V 0.12 Neutral PMS2 P54278 N612W 612 N W 0.446 Neutral PMS2 P54278 N612Y 612 N Y 0.402 Neutral PMS2 P54278 K613A 613 K A 0.096 Neutral PMS2 P54278 K613C 613 K C 0.036 Neutral PMS2 P54278 K613D 613 K D 0.05 Neutral PMS2 P54278 K613E 613 K E 0.004 Neutral PMS2 P54278 K613F 613 K F 0.234 Neutral PMS2 P54278 K613G 613 K G 0.134 Neutral PMS2 P54278 K613H 613 K H 0.048 Neutral PMS2 P54278 K613I 613 K I 0.248 Neutral PMS2 P54278 K613L 613 K L 0.166 Neutral PMS2 P54278 K613M 613 K M 0.112 Neutral PMS2 P54278 K613N 613 K N 0.082 Neutral PMS2 P54278 K613P 613 K P 0.232 Neutral PMS2 P54278 K613Q 613 K Q 0.09 Neutral PMS2 P54278 K613R 613 K R 0.002 Neutral PMS2 P54278 K613S 613 K S 0.014 Neutral PMS2 P54278 K613T 613 K T 0.09 Neutral PMS2 P54278 K613V 613 K V 0.198 Neutral PMS2 P54278 K613W 613 K W 0.474 Neutral PMS2 P54278 K613Y 613 K Y 0.39 Neutral PMS2 P54278 K614A 614 K A 0.096 Neutral PMS2 P54278 K614C 614 K C 0.028 Neutral PMS2 P54278 K614D 614 K D 0.046 Neutral PMS2 P54278 K614E 614 K E 0.052 Neutral PMS2 P54278 K614F 614 K F 0.234 Neutral PMS2 P54278 K614G 614 K G 0.134 Neutral PMS2 P54278 K614H 614 K H 0.048 Neutral PMS2 P54278 K614I 614 K I 0.212 Neutral PMS2 P54278 K614L 614 K L 0.236 Neutral PMS2 P54278 K614M 614 K M 0.112 Neutral PMS2 P54278 K614N 614 K N 0.082 Neutral PMS2 P54278 K614P 614 K P 0.016 Neutral PMS2 P54278 K614Q 614 K Q 0.09 Neutral PMS2 P54278 K614R 614 K R 0.002 Neutral PMS2 P54278 K614S 614 K S 0.09 Neutral PMS2 P54278 K614T 614 K T 0.09 Neutral PMS2 P54278 K614V 614 K V 0.198 Neutral PMS2 P54278 K614W 614 K W 0.474 Neutral PMS2 P54278 K614Y 614 K Y 0.39 Neutral PMS2 P54278 V615A 615 V A 0.052 Neutral PMS2 P54278 V615C 615 V C 0.058 Neutral PMS2 P54278 V615D 615 V D 0.126 Neutral PMS2 P54278 V615E 615 V E 0.042 Neutral PMS2 P54278 V615F 615 V F 0.172 Neutral PMS2 P54278 V615G 615 V G 0.196 Neutral PMS2 P54278 V615H 615 V H 0.112 Neutral PMS2 P54278 V615I 615 V I 0.008 Neutral PMS2 P54278 V615K 615 V K 0.06 Neutral PMS2 P54278 V615L 615 V L 0.054 Neutral PMS2 P54278 V615M 615 V M 0.03 Neutral PMS2 P54278 V615N 615 V N 0.138 Neutral PMS2 P54278 V615P 615 V P 0.19 Neutral PMS2 P54278 V615Q 615 V Q 0.158 Neutral PMS2 P54278 V615R 615 V R 0.208 Neutral PMS2 P54278 V615S 615 V S 0.07 Neutral PMS2 P54278 V615T 615 V T 0.008 Neutral PMS2 P54278 V615W 615 V W 0.344 Neutral PMS2 P54278 V615Y 615 V Y 0.256 Neutral PMS2 P54278 V616A 616 V A 0.052 Neutral PMS2 P54278 V616C 616 V C 0.064 Neutral PMS2 P54278 V616D 616 V D 0.14 Neutral PMS2 P54278 V616E 616 V E 0.116 Neutral PMS2 P54278 V616F 616 V F 0.23 Neutral PMS2 P54278 V616G 616 V G 0.204 Neutral PMS2 P54278 V616H 616 V H 0.154 Neutral PMS2 P54278 V616I 616 V I 0.066 Neutral PMS2 P54278 V616K 616 V K 0.072 Neutral PMS2 P54278 V616L 616 V L 0 Neutral PMS2 P54278 V616M 616 V M 0.05 Neutral PMS2 P54278 V616N 616 V N 0.152 Neutral PMS2 P54278 V616P 616 V P 0.212 Neutral PMS2 P54278 V616Q 616 V Q 0.264 Neutral PMS2 P54278 V616R 616 V R 0.296 Neutral PMS2 P54278 V616S 616 V S 0.066 Neutral PMS2 P54278 V616T 616 V T 0.008 Neutral PMS2 P54278 V616W 616 V W 0.406 Neutral PMS2 P54278 V616Y 616 V Y 0.32 Neutral PMS2 P54278 P617A 617 P A 0.034 Neutral PMS2 P54278 P617C 617 P C 0.148 Neutral PMS2 P54278 P617D 617 P D 0.078 Neutral PMS2 P54278 P617E 617 P E 0.166 Neutral PMS2 P54278 P617F 617 P F 0.272 Neutral PMS2 P54278 P617G 617 P G 0.092 Neutral PMS2 P54278 P617H 617 P H 0.232 Neutral PMS2 P54278 P617I 617 P I 0.1 Neutral PMS2 P54278 P617K 617 P K 0.1 Neutral PMS2 P54278 P617L 617 P L 0.056 Neutral PMS2 P54278 P617M 617 P M 0.22 Neutral PMS2 P54278 P617N 617 P N 0.068 Neutral PMS2 P54278 P617Q 617 P Q 0.212 Neutral PMS2 P54278 P617R 617 P R 0.202 Neutral PMS2 P54278 P617S 617 P S 0.022 Neutral PMS2 P54278 P617T 617 P T 0.014 Neutral PMS2 P54278 P617V 617 P V 0.042 Neutral PMS2 P54278 P617W 617 P W 0.39 Neutral PMS2 P54278 P617Y 617 P Y 0.32 Neutral PMS2 P54278 L618A 618 L A 0.124 Neutral PMS2 P54278 L618C 618 L C 0.13 Neutral PMS2 P54278 L618D 618 L D 0.112 Neutral PMS2 P54278 L618E 618 L E 0.218 Neutral PMS2 P54278 L618F 618 L F 0.39 Neutral PMS2 P54278 L618G 618 L G 0.156 Neutral PMS2 P54278 L618H 618 L H 0.122 Neutral PMS2 P54278 L618I 618 L I 0.114 Neutral PMS2 P54278 L618K 618 L K 0.174 Neutral PMS2 P54278 L618M 618 L M 0.184 Neutral PMS2 P54278 L618N 618 L N 0.224 Neutral PMS2 P54278 L618P 618 L P 0.108 Neutral PMS2 P54278 L618Q 618 L Q 0.1 Neutral PMS2 P54278 L618R 618 L R 0.408 Neutral PMS2 P54278 L618S 618 L S 0.252 Neutral PMS2 P54278 L618T 618 L T 0.11 Neutral PMS2 P54278 L618V 618 L V 0.222 Neutral PMS2 P54278 L618W 618 L W 0.512 Pathogenic PMS2 P54278 L618Y 618 L Y 0.468 Neutral PMS2 P54278 D619A 619 D A 0.014 Neutral PMS2 P54278 D619C 619 D C 0.17 Neutral PMS2 P54278 D619E 619 D E 0.014 Neutral PMS2 P54278 D619F 619 D F 0.406 Neutral PMS2 P54278 D619G 619 D G 0.14 Neutral PMS2 P54278 D619H 619 D H 0.09 Neutral PMS2 P54278 D619I 619 D I 0.262 Neutral PMS2 P54278 D619K 619 D K 0.21 Neutral PMS2 P54278 D619L 619 D L 0.024 Neutral PMS2 P54278 D619M 619 D M 0.19 Neutral PMS2 P54278 D619N 619 D N 0.012 Neutral PMS2 P54278 D619P 619 D P 0.066 Neutral PMS2 P54278 D619Q 619 D Q 0.078 Neutral PMS2 P54278 D619R 619 D R 0.15 Neutral PMS2 P54278 D619S 619 D S 0.196 Neutral PMS2 P54278 D619T 619 D T 0.012 Neutral PMS2 P54278 D619V 619 D V 0.262 Neutral PMS2 P54278 D619W 619 D W 0.434 Neutral PMS2 P54278 D619Y 619 D Y 0.404 Neutral PMS2 P54278 G62A 62 G A 0.588 Pathogenic PMS2 P54278 G62C 62 G C 0.918 Pathogenic PMS2 P54278 G62D 62 G D 0.958 Pathogenic PMS2 P54278 G62E 62 G E 0.98 Pathogenic PMS2 P54278 G62F 62 G F 0.986 Pathogenic PMS2 P54278 G62H 62 G H 0.986 Pathogenic PMS2 P54278 G62I 62 G I 0.976 Pathogenic PMS2 P54278 G62K 62 G K 0.988 Pathogenic PMS2 P54278 G62L 62 G L 0.986 Pathogenic PMS2 P54278 G62M 62 G M 0.99 Pathogenic PMS2 P54278 G62N 62 G N 0.918 Pathogenic PMS2 P54278 G62P 62 G P 0.976 Pathogenic PMS2 P54278 G62Q 62 G Q 0.964 Pathogenic PMS2 P54278 G62R 62 G R 0.998 Pathogenic PMS2 P54278 G62S 62 G S 0.928 Pathogenic PMS2 P54278 G62T 62 G T 0.906 Pathogenic PMS2 P54278 G62V 62 G V 0.988 Pathogenic PMS2 P54278 G62W 62 G W 0.976 Pathogenic PMS2 P54278 G62Y 62 G Y 0.98 Pathogenic PMS2 P54278 F620A 620 F A 0.118 Neutral PMS2 P54278 F620C 620 F C 0.098 Neutral PMS2 P54278 F620D 620 F D 0.182 Neutral PMS2 P54278 F620E 620 F E 0.214 Neutral PMS2 P54278 F620G 620 F G 0.158 Neutral PMS2 P54278 F620H 620 F H 0.048 Neutral PMS2 P54278 F620I 620 F I 0.066 Neutral PMS2 P54278 F620K 620 F K 0.198 Neutral PMS2 P54278 F620L 620 F L 0.042 Neutral PMS2 P54278 F620M 620 F M 0.096 Neutral PMS2 P54278 F620N 620 F N 0.194 Neutral PMS2 P54278 F620P 620 F P 0.066 Neutral PMS2 P54278 F620Q 620 F Q 0.062 Neutral PMS2 P54278 F620R 620 F R 0.18 Neutral PMS2 P54278 F620S 620 F S 0.224 Neutral PMS2 P54278 F620T 620 F T 0.236 Neutral PMS2 P54278 F620V 620 F V 0.18 Neutral PMS2 P54278 F620W 620 F W 0.388 Neutral PMS2 P54278 F620Y 620 F Y 0.118 Neutral PMS2 P54278 S621A 621 S A 0.018 Neutral PMS2 P54278 S621C 621 S C 0.07 Neutral PMS2 P54278 S621D 621 S D 0.112 Neutral PMS2 P54278 S621E 621 S E 0.326 Neutral PMS2 P54278 S621F 621 S F 0.366 Neutral PMS2 P54278 S621G 621 S G 0.112 Neutral PMS2 P54278 S621H 621 S H 0.362 Neutral PMS2 P54278 S621I 621 S I 0.16 Neutral PMS2 P54278 S621K 621 S K 0.362 Neutral PMS2 P54278 S621L 621 S L 0.196 Neutral PMS2 P54278 S621M 621 S M 0.616 Pathogenic PMS2 P54278 S621N 621 S N 0.1 Neutral PMS2 P54278 S621P 621 S P 0.204 Neutral PMS2 P54278 S621Q 621 S Q 0.32 Neutral PMS2 P54278 S621R 621 S R 0.344 Neutral PMS2 P54278 S621T 621 S T 0.184 Neutral PMS2 P54278 S621V 621 S V 0.4 Neutral PMS2 P54278 S621W 621 S W 0.732 Pathogenic PMS2 P54278 S621Y 621 S Y 0.676 Pathogenic PMS2 P54278 M622A 622 M A 0.084 Neutral PMS2 P54278 M622C 622 M C 0.032 Neutral PMS2 P54278 M622D 622 M D 0.164 Neutral PMS2 P54278 M622E 622 M E 0.064 Neutral PMS2 P54278 M622F 622 M F 0.266 Neutral PMS2 P54278 M622G 622 M G 0.138 Neutral PMS2 P54278 M622H 622 M H 0.026 Neutral PMS2 P54278 M622I 622 M I 0.016 Neutral 1 PMS2 P54278 M622K 622 M K 0.048 Neutral PMS2 P54278 M622L 622 M L 0.004 Neutral PMS2 P54278 M622N 622 M N 0.196 Neutral PMS2 P54278 M622P 622 M P 0.23 Neutral PMS2 P54278 M622Q 622 M Q 0.068 Neutral PMS2 P54278 M622R 622 M R 0.18 Neutral PMS2 P54278 M622S 622 M S 0.01 Neutral PMS2 P54278 M622T 622 M T 0.146 Neutral PMS2 P54278 M622V 622 M V 0.136 Neutral PMS2 P54278 M622W 622 M W 0.442 Neutral PMS2 P54278 M622Y 622 M Y 0.38 Neutral PMS2 P54278 S623A 623 S A 0.052 Neutral PMS2 P54278 S623C 623 S C 0.022 Neutral PMS2 P54278 S623D 623 S D 0.024 Neutral PMS2 P54278 S623E 623 S E 0.148 Neutral PMS2 P54278 S623F 623 S F 0.276 Neutral PMS2 P54278 S623G 623 S G 0.064 Neutral PMS2 P54278 S623H 623 S H 0.188 Neutral PMS2 P54278 S623I 623 S I 0.124 Neutral PMS2 P54278 S623K 623 S K 0.162 Neutral PMS2 P54278 S623L 623 S L 0.032 Neutral PMS2 P54278 S623M 623 S M 0.28 Neutral PMS2 P54278 S623N 623 S N 0 Neutral PMS2 P54278 S623P 623 S P 0.132 Neutral PMS2 P54278 S623Q 623 S Q 0.16 Neutral PMS2 P54278 S623R 623 S R 0.154 Neutral PMS2 P54278 S623T 623 S T 0.046 Neutral PMS2 P54278 S623V 623 S V 0.248 Neutral PMS2 P54278 S623W 623 S W 0.49 Neutral PMS2 P54278 S623Y 623 S Y 0.448 Neutral PMS2 P54278 S624A 624 S A 0.018 Neutral PMS2 P54278 S624C 624 S C 0.032 Neutral PMS2 P54278 S624D 624 S D 0.044 Neutral PMS2 P54278 S624E 624 S E 0.122 Neutral PMS2 P54278 S624F 624 S F 0.276 Neutral PMS2 P54278 S624G 624 S G 0.064 Neutral PMS2 P54278 S624H 624 S H 0.238 Neutral PMS2 P54278 S624I 624 S I 0.124 Neutral PMS2 P54278 S624K 624 S K 0.15 Neutral PMS2 P54278 S624L 624 S L 0.062 Neutral PMS2 P54278 S624M 624 S M 0.28 Neutral PMS2 P54278 S624N 624 S N 0.012 Neutral PMS2 P54278 S624P 624 S P 0.116 Neutral PMS2 P54278 S624Q 624 S Q 0.172 Neutral PMS2 P54278 S624R 624 S R 0.138 Neutral PMS2 P54278 S624T 624 S T 0.02 Neutral PMS2 P54278 S624V 624 S V 0.034 Neutral PMS2 P54278 S624W 624 S W 0.49 Neutral PMS2 P54278 S624Y 624 S Y 0.434 Neutral PMS2 P54278 L625A 625 L A 0.072 Neutral PMS2 P54278 L625C 625 L C 0.13 Neutral PMS2 P54278 L625D 625 L D 0.222 Neutral PMS2 P54278 L625E 625 L E 0.038 Neutral PMS2 P54278 L625F 625 L F 0.39 Neutral PMS2 P54278 L625G 625 L G 0.25 Neutral PMS2 P54278 L625H 625 L H 0.122 Neutral PMS2 P54278 L625I 625 L I 0.056 Neutral PMS2 P54278 L625K 625 L K 0.174 Neutral PMS2 P54278 L625M 625 L M 0.184 Neutral PMS2 P54278 L625N 625 L N 0.206 Neutral PMS2 P54278 L625P 625 L P 0.32 Neutral PMS2 P54278 L625Q 625 L Q 0.03 Neutral PMS2 P54278 L625R 625 L R 0.408 Neutral PMS2 P54278 L625S 625 L S 0.186 Neutral PMS2 P54278 L625T 625 L T 0.11 Neutral PMS2 P54278 L625V 625 L V 0.168 Neutral PMS2 P54278 L625W 625 L W 0.512 Pathogenic PMS2 P54278 L625Y 625 L Y 0.468 Neutral PMS2 P54278 A626C 626 A C 0.192 Neutral PMS2 P54278 A626D 626 A D 0.28 Neutral PMS2 P54278 A626E 626 A E 0.308 Neutral PMS2 P54278 A626F 626 A F 0.48 Neutral PMS2 P54278 A626G 626 A G 0.162 Neutral PMS2 P54278 A626H 626 A H 0.314 Neutral PMS2 P54278 A626I 626 A I 0.466 Neutral PMS2 P54278 A626K 626 A K 0.366 Neutral PMS2 P54278 A626L 626 A L 0.32 Neutral PMS2 P54278 A626M 626 A M 0.3 Neutral PMS2 P54278 A626N 626 A N 0.288 Neutral PMS2 P54278 A626P 626 A P 0.32 Neutral PMS2 P54278 A626Q 626 A Q 0.312 Neutral PMS2 P54278 A626R 626 A R 0.308 Neutral PMS2 P54278 A626S 626 A S 0.068 Neutral PMS2 P54278 A626T 626 A T 0.02 Neutral PMS2 P54278 A626V 626 A V 0.044 Neutral PMS2 P54278 A626W 626 A W 0.514 Pathogenic PMS2 P54278 A626Y 626 A Y 0.512 Pathogenic PMS2 P54278 K627A 627 K A 0.028 Neutral PMS2 P54278 K627C 627 K C 0.028 Neutral PMS2 P54278 K627D 627 K D 0.002 Neutral PMS2 P54278 K627E 627 K E 0.004 Neutral PMS2 P54278 K627F 627 K F 0.23 Neutral PMS2 P54278 K627G 627 K G 0.132 Neutral PMS2 P54278 K627H 627 K H 0.018 Neutral PMS2 P54278 K627I 627 K I 0.222 Neutral PMS2 P54278 K627L 627 K L 0.104 Neutral PMS2 P54278 K627M 627 K M 0.106 Neutral PMS2 P54278 K627N 627 K N 0.05 Neutral PMS2 P54278 K627P 627 K P 0.214 Neutral PMS2 P54278 K627Q 627 K Q 0.09 Neutral PMS2 P54278 K627R 627 K R 0.016 Neutral PMS2 P54278 K627S 627 K S 0.22 Neutral PMS2 P54278 K627T 627 K T 0.092 Neutral PMS2 P54278 K627V 627 K V 0.18 Neutral PMS2 P54278 K627W 627 K W 0.396 Neutral PMS2 P54278 K627Y 627 K Y 0.326 Neutral PMS2 P54278 R628A 628 R A 0.064 Neutral PMS2 P54278 R628C 628 R C 0.154 Neutral PMS2 P54278 R628D 628 R D 0.182 Neutral PMS2 P54278 R628E 628 R E 0.088 Neutral PMS2 P54278 R628F 628 R F 0.298 Neutral PMS2 P54278 R628G 628 R G 0.002 Neutral PMS2 P54278 R628H 628 R H 0.122 Neutral PMS2 P54278 R628I 628 R I 0.322 Neutral PMS2 P54278 R628K 628 R K 0.004 Neutral PMS2 P54278 R628L 628 R L 0.284 Neutral PMS2 P54278 R628M 628 R M 0.164 Neutral PMS2 P54278 R628N 628 R N 0.2 Neutral PMS2 P54278 R628P 628 R P 0.274 Neutral PMS2 P54278 R628Q 628 R Q 0.01 Neutral PMS2 P54278 R628S 628 R S 0.062 Neutral PMS2 P54278 R628T 628 R T 0.144 Neutral PMS2 P54278 R628V 628 R V 0.254 Neutral PMS2 P54278 R628W 628 R W 0.414 Neutral PMS2 P54278 R628Y 628 R Y 0.298 Neutral PMS2 P54278 I629A 629 I A 0.072 Neutral PMS2 P54278 I629C 629 I C 0.09 Neutral PMS2 P54278 I629D 629 I D 0.166 Neutral PMS2 P54278 I629E 629 I E 0.14 Neutral PMS2 P54278 I629F 629 I F 0.144 Neutral PMS2 P54278 I629G 629 I G 0.23 Neutral PMS2 P54278 I629H 629 I H 0.046 Neutral PMS2 P54278 I629K 629 I K 0.068 Neutral PMS2 P54278 I629L 629 I L 0 Neutral PMS2 P54278 I629M 629 I M 0.02 Neutral PMS2 P54278 I629N 629 I N 0.176 Neutral PMS2 P54278 I629P 629 I P 0.174 Neutral PMS2 P54278 I629Q 629 I Q 0.198 Neutral PMS2 P54278 I629R 629 I R 0.23 Neutral PMS2 P54278 I629S 629 I S 0.16 Neutral PMS2 P54278 I629T 629 I T 0.114 Neutral PMS2 P54278 I629V 629 I V 0 Neutral PMS2 P54278 I629W 629 I W 0.344 Neutral PMS2 P54278 I629Y 629 I Y 0.298 Neutral PMS2 P54278 V63A 63 V A 0 Neutral PMS2 P54278 V63C 63 V C 0.088 Neutral PMS2 P54278 V63D 63 V D 0.196 Neutral PMS2 P54278 V63E 63 V E 0.062 Neutral PMS2 P54278 V63F 63 V F 0.26 Neutral PMS2 P54278 V63G 63 V G 0.138 Neutral PMS2 P54278 V63H 63 V H 0.228 Neutral PMS2 P54278 V63I 63 V I 0.01 Neutral PMS2 P54278 V63K 63 V K 0.082 Neutral PMS2 P54278 V63L 63 V L 0.006 Neutral PMS2 P54278 V63M 63 V M 0.024 Neutral PMS2 P54278 V63N 63 V N 0.216 Neutral PMS2 P54278 V63P 63 V P 0.346 Neutral PMS2 P54278 V63Q 63 V Q 0.072 Neutral PMS2 P54278 V63R 63 V R 0.49 Neutral PMS2 P54278 V63S 63 V S 0.016 Neutral PMS2 P54278 V63T 63 V T 0.008 Neutral PMS2 P54278 V63W 63 V W 0.554 Pathogenic PMS2 P54278 V63Y 63 V Y 0.372 Neutral PMS2 P54278 K630A 630 K A 0.054 Neutral PMS2 P54278 K630C 630 K C 0.028 Neutral PMS2 P54278 K630D 630 K D 0.066 Neutral PMS2 P54278 K630E 630 K E 0.03 Neutral PMS2 P54278 K630F 630 K F 0.212 Neutral PMS2 P54278 K630G 630 K G 0.13 Neutral PMS2 P54278 K630H 630 K H 0.048 Neutral PMS2 P54278 K630I 630 K I 0.19 Neutral PMS2 P54278 K630L 630 K L 0.104 Neutral PMS2 P54278 K630M 630 K M 0.024 Neutral PMS2 P54278 K630N 630 K N 0.006 Neutral PMS2 P54278 K630P 630 K P 0.214 Neutral PMS2 P54278 K630Q 630 K Q 0.006 Neutral PMS2 P54278 K630R 630 K R 0.002 Neutral PMS2 P54278 K630S 630 K S 0.09 Neutral PMS2 P54278 K630T 630 K T 0.18 Neutral PMS2 P54278 K630V 630 K V 0.12 Neutral PMS2 P54278 K630W 630 K W 0.396 Neutral PMS2 P54278 K630Y 630 K Y 0.326 Neutral PMS2 P54278 Q631A 631 Q A 0.1 Neutral PMS2 P54278 Q631C 631 Q C 0.082 Neutral PMS2 P54278 Q631D 631 Q D 0.046 Neutral PMS2 P54278 Q631E 631 Q E 0.068 Neutral PMS2 P54278 Q631F 631 Q F 0.26 Neutral PMS2 P54278 Q631G 631 Q G 0.116 Neutral PMS2 P54278 Q631H 631 Q H 0.14 Neutral PMS2 P54278 Q631I 631 Q I 0.278 Neutral PMS2 P54278 Q631K 631 Q K 0.02 Neutral PMS2 P54278 Q631L 631 Q L 0.146 Neutral PMS2 P54278 Q631M 631 Q M 0.186 Neutral PMS2 P54278 Q631N 631 Q N 0.094 Neutral PMS2 P54278 Q631P 631 Q P 0.368 Neutral PMS2 P54278 Q631R 631 Q R 0.002 Neutral PMS2 P54278 Q631S 631 Q S 0.112 Neutral PMS2 P54278 Q631T 631 Q T 0.13 Neutral PMS2 P54278 Q631V 631 Q V 0.092 Neutral PMS2 P54278 Q631W 631 Q W 0.432 Neutral PMS2 P54278 Q631Y 631 Q Y 0.362 Neutral PMS2 P54278 L632A 632 L A 0.06 Neutral PMS2 P54278 L632C 632 L C 0.094 Neutral PMS2 P54278 L632D 632 L D 0.166 Neutral PMS2 P54278 L632E 632 L E 0.116 Neutral PMS2 P54278 L632F 632 L F 0.228 Neutral PMS2 P54278 L632G 632 L G 0.188 Neutral PMS2 P54278 L632H 632 L H 0.084 Neutral PMS2 P54278 L632I 632 L I 0.004 Neutral PMS2 P54278 L632K 632 L K 0.186 Neutral PMS2 P54278 L632M 632 L M 0.132 Neutral PMS2 P54278 L632N 632 L N 0.156 Neutral PMS2 P54278 L632P 632 L P 0.232 Neutral PMS2 P54278 L632Q 632 L Q 0.018 Neutral PMS2 P54278 L632R 632 L R 0.272 Neutral PMS2 P54278 L632S 632 L S 0.086 Neutral PMS2 P54278 L632T 632 L T 0.114 Neutral PMS2 P54278 L632V 632 L V 0 Neutral PMS2 P54278 L632W 632 L W 0.372 Neutral PMS2 P54278 L632Y 632 L Y 0.324 Neutral PMS2 P54278 H633A 633 H A 0.108 Neutral PMS2 P54278 H633C 633 H C 0 Neutral PMS2 P54278 H633D 633 H D 0.032 Neutral PMS2 P54278 H633E 633 H E 0.058 Neutral PMS2 P54278 H633F 633 H F 0.246 Neutral PMS2 P54278 H633G 633 H G 0.13 Neutral PMS2 P54278 H633I 633 H I 0.014 Neutral PMS2 P54278 H633K 633 H K 0.086 Neutral PMS2 P54278 H633L 633 H L 0.016 Neutral PMS2 P54278 H633M 633 H M 0.092 Neutral PMS2 P54278 H633N 633 H N 0.058 Neutral PMS2 P54278 H633P 633 H P 0.274 Neutral PMS2 P54278 H633Q 633 H Q 0.006 Neutral PMS2 P54278 H633R 633 H R 0 Neutral PMS2 P54278 H633S 633 H S 0.154 Neutral PMS2 P54278 H633T 633 H T 0.062 Neutral PMS2 P54278 H633V 633 H V 0.064 Neutral PMS2 P54278 H633W 633 H W 0.404 Neutral PMS2 P54278 H633Y 633 H Y 0.148 Neutral PMS2 P54278 H634A 634 H A 0.076 Neutral PMS2 P54278 H634C 634 H C 0.042 Neutral PMS2 P54278 H634D 634 H D 0.028 Neutral PMS2 P54278 H634E 634 H E 0.028 Neutral PMS2 P54278 H634F 634 H F 0.246 Neutral PMS2 P54278 H634G 634 H G 0.13 Neutral PMS2 P54278 H634I 634 H I 0.274 Neutral PMS2 P54278 H634K 634 H K 0.116 Neutral PMS2 P54278 H634L 634 H L 0.044 Neutral PMS2 P54278 H634M 634 H M 0.108 Neutral PMS2 P54278 H634N 634 H N 0.058 Neutral PMS2 P54278 H634P 634 H P 0.21 Neutral PMS2 P54278 H634Q 634 H Q 0.006 Neutral PMS2 P54278 H634R 634 H R 0 Neutral PMS2 P54278 H634S 634 H S 0.154 Neutral PMS2 P54278 H634T 634 H T 0.186 Neutral PMS2 P54278 H634V 634 H V 0.132 Neutral PMS2 P54278 H634W 634 H W 0.398 Neutral PMS2 P54278 H634Y 634 H Y 0.252 Neutral PMS2 P54278 E635A 635 E A 0.212 Neutral PMS2 P54278 E635C 635 E C 0.068 Neutral PMS2 P54278 E635D 635 E D 0 Neutral PMS2 P54278 E635F 635 E F 0.28 Neutral PMS2 P54278 E635G 635 E G 0.054 Neutral PMS2 P54278 E635H 635 E H 0.106 Neutral PMS2 P54278 E635I 635 E I 0.332 Neutral PMS2 P54278 E635K 635 E K 0.164 Neutral PMS2 P54278 E635L 635 E L 0.046 Neutral PMS2 P54278 E635M 635 E M 0.172 Neutral PMS2 P54278 E635N 635 E N 0.056 Neutral PMS2 P54278 E635P 635 E P 0.288 Neutral PMS2 P54278 E635Q 635 E Q 0.002 Neutral PMS2 P54278 E635R 635 E R 0.01 Neutral PMS2 P54278 E635S 635 E S 0.17 Neutral PMS2 P54278 E635T 635 E T 0.144 Neutral PMS2 P54278 E635V 635 E V 0.24 Neutral PMS2 P54278 E635W 635 E W 0.448 Neutral PMS2 P54278 E635Y 635 E Y 0.356 Neutral PMS2 P54278 A636C 636 A C 0.182 Neutral PMS2 P54278 A636D 636 A D 0.33 Neutral PMS2 P54278 A636E 636 A E 0.286 Neutral PMS2 P54278 A636F 636 A F 0.468 Neutral PMS2 P54278 A636G 636 A G 0.006 Neutral PMS2 P54278 A636H 636 A H 0.304 Neutral PMS2 P54278 A636I 636 A I 0.406 Neutral PMS2 P54278 A636K 636 A K 0.276 Neutral PMS2 P54278 A636L 636 A L 0.32 Neutral PMS2 P54278 A636M 636 A M 0.29 Neutral PMS2 P54278 A636N 636 A N 0.314 Neutral PMS2 P54278 A636P 636 A P 0.272 Neutral PMS2 P54278 A636Q 636 A Q 0.26 Neutral PMS2 P54278 A636R 636 A R 0.326 Neutral PMS2 P54278 A636S 636 A S 0.156 Neutral PMS2 P54278 A636T 636 A T 0.03 Neutral PMS2 P54278 A636V 636 A V 0.202 Neutral PMS2 P54278 A636W 636 A W 0.504 Pathogenic PMS2 P54278 A636Y 636 A Y 0.5 Pathogenic PMS2 P54278 Q637A 637 Q A 0.138 Neutral PMS2 P54278 Q637C 637 Q C 0.082 Neutral PMS2 P54278 Q637D 637 Q D 0.054 Neutral PMS2 P54278 Q637E 637 Q E 0.008 Neutral PMS2 P54278 Q637F 637 Q F 0.362 Neutral PMS2 P54278 Q637G 637 Q G 0.116 Neutral PMS2 P54278 Q637H 637 Q H 0.034 Neutral PMS2 P54278 Q637I 637 Q I 0.278 Neutral PMS2 P54278 Q637K 637 Q K 0.222 Neutral PMS2 P54278 Q637L 637 Q L 0.242 Neutral PMS2 P54278 Q637M 637 Q M 0.186 Neutral PMS2 P54278 Q637N 637 Q N 0.018 Neutral PMS2 P54278 Q637P 637 Q P 0.368 Neutral PMS2 P54278 Q637R 637 Q R 0.002 Neutral PMS2 P54278 Q637S 637 Q S 0.184 Neutral PMS2 P54278 Q637T 637 Q T 0.13 Neutral PMS2 P54278 Q637V 637 Q V 0.268 Neutral PMS2 P54278 Q637W 637 Q W 0.42 Neutral PMS2 P54278 Q637Y 637 Q Y 0.362 Neutral PMS2 P54278 Q638A 638 Q A 0.138 Neutral PMS2 P54278 Q638C 638 Q C 0.082 Neutral PMS2 P54278 Q638D 638 Q D 0.046 Neutral PMS2 P54278 Q638E 638 Q E 0.008 Neutral PMS2 P54278 Q638F 638 Q F 0.26 Neutral PMS2 P54278 Q638G 638 Q G 0.136 Neutral PMS2 P54278 Q638H 638 Q H 0.214 Neutral PMS2 P54278 Q638I 638 Q I 0.354 Neutral PMS2 P54278 Q638K 638 Q K 0.02 Neutral PMS2 P54278 Q638L 638 Q L 0.242 Neutral PMS2 P54278 Q638M 638 Q M 0.186 Neutral PMS2 P54278 Q638N 638 Q N 0.064 Neutral PMS2 P54278 Q638P 638 Q P 0.22 Neutral PMS2 P54278 Q638R 638 Q R 0.004 Neutral PMS2 P54278 Q638S 638 Q S 0.054 Neutral PMS2 P54278 Q638T 638 Q T 0.144 Neutral PMS2 P54278 Q638V 638 Q V 0.268 Neutral PMS2 P54278 Q638W 638 Q W 0.42 Neutral PMS2 P54278 Q638Y 638 Q Y 0.452 Neutral PMS2 P54278 S639A 639 S A 0.01 Neutral PMS2 P54278 S639C 639 S C 0.022 Neutral PMS2 P54278 S639D 639 S D 0.024 Neutral PMS2 P54278 S639E 639 S E 0.148 Neutral PMS2 P54278 S639F 639 S F 0.264 Neutral PMS2 P54278 S639G 639 S G 0.066 Neutral PMS2 P54278 S639H 639 S H 0.188 Neutral PMS2 P54278 S639I 639 S I 0.026 Neutral PMS2 P54278 S639K 639 S K 0.164 Neutral PMS2 P54278 S639L 639 S L 0.042 Neutral PMS2 P54278 S639M 639 S M 0.332 Neutral PMS2 P54278 S639N 639 S N 0 Neutral PMS2 P54278 S639P 639 S P 0.116 Neutral PMS2 P54278 S639Q 639 S Q 0.19 Neutral PMS2 P54278 S639R 639 S R 0.152 Neutral PMS2 P54278 S639T 639 S T 0.176 Neutral PMS2 P54278 S639V 639 S V 0.248 Neutral PMS2 P54278 S639W 639 S W 0.49 Neutral PMS2 P54278 S639Y 639 S Y 0.448 Neutral PMS2 P54278 D64A 64 D A 0.188 Neutral PMS2 P54278 D64C 64 D C 0.744 Pathogenic PMS2 P54278 D64E 64 D E 0.178 Neutral PMS2 P54278 D64F 64 D F 0.95 Pathogenic PMS2 P54278 D64G 64 D G 0.166 Neutral PMS2 P54278 D64H 64 D H 0.08 Neutral PMS2 P54278 D64I 64 D I 0.828 Pathogenic PMS2 P54278 D64K 64 D K 0.05 Neutral PMS2 P54278 D64L 64 D L 0.778 Pathogenic PMS2 P54278 D64M 64 D M 0.74 Pathogenic PMS2 P54278 D64N 64 D N 0.398 Neutral PMS2 P54278 D64P 64 D P 0.812 Pathogenic PMS2 P54278 D64Q 64 D Q 0.012 Neutral PMS2 P54278 D64R 64 D R 0.484 Neutral PMS2 P54278 D64S 64 D S 0.044 Neutral PMS2 P54278 D64T 64 D T 0.058 Neutral PMS2 P54278 D64V 64 D V 0.802 Pathogenic PMS2 P54278 D64W 64 D W 0.968 Pathogenic PMS2 P54278 D64Y 64 D Y 0.96 Pathogenic PMS2 P54278 E640A 640 E A 0.068 Neutral PMS2 P54278 E640C 640 E C 0.068 Neutral PMS2 P54278 E640D 640 E D 0 Neutral PMS2 P54278 E640F 640 E F 0.272 Neutral PMS2 P54278 E640G 640 E G 0.002 Neutral PMS2 P54278 E640H 640 E H 0.104 Neutral PMS2 P54278 E640I 640 E I 0.284 Neutral PMS2 P54278 E640K 640 E K 0.002 Neutral PMS2 P54278 E640L 640 E L 0.138 Neutral PMS2 P54278 E640M 640 E M 0.166 Neutral PMS2 P54278 E640N 640 E N 0.056 Neutral PMS2 P54278 E640P 640 E P 0.3 Neutral PMS2 P54278 E640Q 640 E Q 0.056 Neutral PMS2 P54278 E640R 640 E R 0.016 Neutral PMS2 P54278 E640S 640 E S 0.168 Neutral PMS2 P54278 E640T 640 E T 0.006 Neutral PMS2 P54278 E640V 640 E V 0.04 Neutral PMS2 P54278 E640W 640 E W 0.43 Neutral PMS2 P54278 E640Y 640 E Y 0.338 Neutral PMS2 P54278 G641A 641 G A 0.01 Neutral PMS2 P54278 G641C 641 G C 0.14 Neutral PMS2 P54278 G641D 641 G D 0.134 Neutral PMS2 P54278 G641E 641 G E 0.192 Neutral PMS2 P54278 G641F 641 G F 0.478 Neutral PMS2 P54278 G641H 641 G H 0.324 Neutral PMS2 P54278 G641I 641 G I 0.412 Neutral PMS2 P54278 G641K 641 G K 0.27 Neutral PMS2 P54278 G641L 641 G L 0.412 Neutral PMS2 P54278 G641M 641 G M 0.422 Neutral PMS2 P54278 G641N 641 G N 0.252 Neutral PMS2 P54278 G641P 641 G P 0.392 Neutral PMS2 P54278 G641Q 641 G Q 0.194 Neutral PMS2 P54278 G641R 641 G R 0.362 Neutral PMS2 P54278 G641S 641 G S 0.016 Neutral PMS2 P54278 G641T 641 G T 0.272 Neutral PMS2 P54278 G641V 641 G V 0.39 Neutral PMS2 P54278 G641W 641 G W 0.498 Neutral PMS2 P54278 G641Y 641 G Y 0.5 Pathogenic PMS2 P54278 E642A 642 E A 0.066 Neutral PMS2 P54278 E642C 642 E C 0.068 Neutral PMS2 P54278 E642D 642 E D 0 Neutral PMS2 P54278 E642F 642 E F 0.272 Neutral PMS2 P54278 E642G 642 E G 0.004 Neutral PMS2 P54278 E642H 642 E H 0.162 Neutral PMS2 P54278 E642I 642 E I 0.254 Neutral PMS2 P54278 E642K 642 E K 0.006 Neutral PMS2 P54278 E642L 642 E L 0.286 Neutral PMS2 P54278 E642M 642 E M 0.076 Neutral PMS2 P54278 E642N 642 E N 0.056 Neutral PMS2 P54278 E642P 642 E P 0.282 Neutral PMS2 P54278 E642Q 642 E Q 0 Neutral PMS2 P54278 E642R 642 E R 0.036 Neutral PMS2 P54278 E642S 642 E S 0.168 Neutral PMS2 P54278 E642T 642 E T 0.006 Neutral PMS2 P54278 E642V 642 E V 0.25 Neutral PMS2 P54278 E642W 642 E W 0.43 Neutral PMS2 P54278 E642Y 642 E Y 0.338 Neutral PMS2 P54278 Q643A 643 Q A 0.102 Neutral PMS2 P54278 Q643C 643 Q C 0.084 Neutral PMS2 P54278 Q643D 643 Q D 0.046 Neutral PMS2 P54278 Q643E 643 Q E 0.068 Neutral PMS2 P54278 Q643F 643 Q F 0.284 Neutral PMS2 P54278 Q643G 643 Q G 0.118 Neutral PMS2 P54278 Q643H 643 Q H 0.27 Neutral PMS2 P54278 Q643I 643 Q I 0.264 Neutral PMS2 P54278 Q643K 643 Q K 0.22 Neutral PMS2 P54278 Q643L 643 Q L 0.13 Neutral PMS2 P54278 Q643M 643 Q M 0.196 Neutral PMS2 P54278 Q643N 643 Q N 0.064 Neutral PMS2 P54278 Q643P 643 Q P 0.276 Neutral PMS2 P54278 Q643R 643 Q R 0.034 Neutral PMS2 P54278 Q643S 643 Q S 0.178 Neutral PMS2 P54278 Q643T 643 Q T 0.146 Neutral PMS2 P54278 Q643V 643 Q V 0.28 Neutral PMS2 P54278 Q643W 643 Q W 0.49 Neutral PMS2 P54278 Q643Y 643 Q Y 0.424 Neutral PMS2 P54278 N644A 644 N A 0.014 Neutral PMS2 P54278 N644C 644 N C 0.014 Neutral PMS2 P54278 N644D 644 N D 0.068 Neutral PMS2 P54278 N644E 644 N E 0.096 Neutral PMS2 P54278 N644F 644 N F 0.34 Neutral PMS2 P54278 N644G 644 N G 0.044 Neutral PMS2 P54278 N644H 644 N H 0.132 Neutral PMS2 P54278 N644I 644 N I 0.336 Neutral PMS2 P54278 N644K 644 N K 0.038 Neutral PMS2 P54278 N644L 644 N L 0.272 Neutral PMS2 P54278 N644M 644 N M 0.22 Neutral PMS2 P54278 N644P 644 N P 0.248 Neutral PMS2 P54278 N644Q 644 N Q 0.166 Neutral PMS2 P54278 N644R 644 N R 0.148 Neutral PMS2 P54278 N644S 644 N S 0.004 Neutral PMS2 P54278 N644T 644 N T 0.142 Neutral PMS2 P54278 N644V 644 N V 0.28 Neutral PMS2 P54278 N644W 644 N W 0.446 Neutral PMS2 P54278 N644Y 644 N Y 0.402 Neutral PMS2 P54278 Y645A 645 Y A 0.132 Neutral PMS2 P54278 Y645C 645 Y C 0.094 Neutral PMS2 P54278 Y645D 645 Y D 0.266 Neutral PMS2 P54278 Y645E 645 Y E 0.26 Neutral PMS2 P54278 Y645F 645 Y F 0.054 Neutral PMS2 P54278 Y645G 645 Y G 0.15 Neutral PMS2 P54278 Y645H 645 Y H 0.09 Neutral PMS2 P54278 Y645I 645 Y I 0.146 Neutral PMS2 P54278 Y645K 645 Y K 0.118 Neutral PMS2 P54278 Y645L 645 Y L 0.082 Neutral PMS2 P54278 Y645M 645 Y M 0.132 Neutral PMS2 P54278 Y645N 645 Y N 0.176 Neutral PMS2 P54278 Y645P 645 Y P 0.124 Neutral PMS2 P54278 Y645Q 645 Y Q 0.14 Neutral PMS2 P54278 Y645R 645 Y R 0.22 Neutral PMS2 P54278 Y645S 645 Y S 0.152 Neutral PMS2 P54278 Y645T 645 Y T 0.148 Neutral PMS2 P54278 Y645V 645 Y V 0.268 Neutral PMS2 P54278 Y645W 645 Y W 0.108 Neutral PMS2 P54278 R646A 646 R A 0.132 Neutral PMS2 P54278 R646C 646 R C 0.246 Neutral PMS2 P54278 R646D 646 R D 0.256 Neutral PMS2 P54278 R646E 646 R E 0.106 Neutral PMS2 P54278 R646F 646 R F 0.44 Neutral PMS2 P54278 R646G 646 R G 0.102 Neutral PMS2 P54278 R646H 646 R H 0.216 Neutral PMS2 P54278 R646I 646 R I 0.478 Neutral PMS2 P54278 R646K 646 R K 0.28 Neutral PMS2 P54278 R646L 646 R L 0.386 Neutral PMS2 P54278 R646M 646 R M 0.258 Neutral PMS2 P54278 R646N 646 R N 0.254 Neutral PMS2 P54278 R646P 646 R P 0.164 Neutral PMS2 P54278 R646Q 646 R Q 0.234 Neutral PMS2 P54278 R646S 646 R S 0.206 Neutral PMS2 P54278 R646T 646 R T 0.212 Neutral PMS2 P54278 R646V 646 R V 0.388 Neutral PMS2 P54278 R646W 646 R W 0.628 Pathogenic PMS2 P54278 R646Y 646 R Y 0.456 Neutral PMS2 P54278 K647A 647 K A 0.054 Neutral PMS2 P54278 K647C 647 K C 0.028 Neutral PMS2 P54278 K647D 647 K D 0.05 Neutral PMS2 P54278 K647E 647 K E 0.072 Neutral PMS2 P54278 K647F 647 K F 0.25 Neutral PMS2 P54278 K647G 647 K G 0.134 Neutral PMS2 P54278 K647H 647 K H 0.02 Neutral PMS2 P54278 K647I 647 K I 0.212 Neutral PMS2 P54278 K647L 647 K L 0.236 Neutral PMS2 P54278 K647M 647 K M 0.154 Neutral PMS2 P54278 K647N 647 K N 0.05 Neutral PMS2 P54278 K647P 647 K P 0.254 Neutral PMS2 P54278 K647Q 647 K Q 0.09 Neutral PMS2 P54278 K647R 647 K R 0.002 Neutral PMS2 P54278 K647S 647 K S 0.176 Neutral PMS2 P54278 K647T 647 K T 0.09 Neutral PMS2 P54278 K647V 647 K V 0.192 Neutral PMS2 P54278 K647W 647 K W 0.474 Neutral PMS2 P54278 K647Y 647 K Y 0.39 Neutral PMS2 P54278 F648A 648 F A 0.134 Neutral PMS2 P54278 F648C 648 F C 0.13 Neutral PMS2 P54278 F648D 648 F D 0.246 Neutral PMS2 P54278 F648E 648 F E 0.28 Neutral PMS2 P54278 F648G 648 F G 0.192 Neutral PMS2 P54278 F648H 648 F H 0.108 Neutral PMS2 P54278 F648I 648 F I 0.134 Neutral PMS2 P54278 F648K 648 F K 0.266 Neutral PMS2 P54278 F648L 648 F L 0.064 Neutral PMS2 P54278 F648M 648 F M 0.124 Neutral PMS2 P54278 F648N 648 F N 0.256 Neutral PMS2 P54278 F648P 648 F P 0.278 Neutral PMS2 P54278 F648Q 648 F Q 0.256 Neutral PMS2 P54278 F648R 648 F R 0.228 Neutral PMS2 P54278 F648S 648 F S 0.22 Neutral PMS2 P54278 F648T 648 F T 0.29 Neutral PMS2 P54278 F648V 648 F V 0.28 Neutral PMS2 P54278 F648W 648 F W 0.468 Neutral PMS2 P54278 F648Y 648 F Y 0.174 Neutral PMS2 P54278 R649A 649 R A 0.122 Neutral PMS2 P54278 R649C 649 R C 0.236 Neutral PMS2 P54278 R649D 649 R D 0.248 Neutral PMS2 P54278 R649E 649 R E 0.196 Neutral PMS2 P54278 R649F 649 R F 0.426 Neutral PMS2 P54278 R649G 649 R G 0.048 Neutral PMS2 P54278 R649H 649 R H 0.208 Neutral PMS2 P54278 R649I 649 R I 0.462 Neutral PMS2 P54278 R649K 649 R K 0.01 Neutral PMS2 P54278 R649L 649 R L 0.424 Neutral PMS2 P54278 R649M 649 R M 0.248 Neutral PMS2 P54278 R649N 649 R N 0.244 Neutral PMS2 P54278 R649P 649 R P 0.406 Neutral PMS2 P54278 R649Q 649 R Q 0.224 Neutral PMS2 P54278 R649S 649 R S 0.202 Neutral PMS2 P54278 R649T 649 R T 0.206 Neutral PMS2 P54278 R649V 649 R V 0.374 Neutral PMS2 P54278 R649W 649 R W 0.614 Pathogenic PMS2 P54278 R649Y 649 R Y 0.44 Neutral PMS2 P54278 L65A 65 L A 0.04 Neutral PMS2 P54278 L65C 65 L C 0.024 Neutral PMS2 P54278 L65D 65 L D 0.606 Pathogenic PMS2 P54278 L65E 65 L E 0.56 Pathogenic PMS2 P54278 L65F 65 L F 0.306 Neutral PMS2 P54278 L65G 65 L G 0.126 Neutral PMS2 P54278 L65H 65 L H 0.346 Neutral PMS2 P54278 L65I 65 L I 0.032 Neutral PMS2 P54278 L65K 65 L K 0.434 Neutral PMS2 P54278 L65M 65 L M 0.438 Neutral PMS2 P54278 L65N 65 L N 0.56 Pathogenic PMS2 P54278 L65P 65 L P 0.832 Pathogenic PMS2 P54278 L65Q 65 L Q 0.036 Neutral PMS2 P54278 L65R 65 L R 0.612 Pathogenic PMS2 P54278 L65S 65 L S 0.044 Neutral PMS2 P54278 L65T 65 L T 0.22 Neutral PMS2 P54278 L65V 65 L V 0.006 Neutral PMS2 P54278 L65W 65 L W 0.544 Pathogenic PMS2 P54278 L65Y 65 L Y 0.632 Pathogenic PMS2 P54278 A650C 650 A C 0.332 Neutral PMS2 P54278 A650D 650 A D 0.528 Pathogenic PMS2 P54278 A650E 650 A E 0.418 Neutral PMS2 P54278 A650F 650 A F 0.662 Pathogenic PMS2 P54278 A650G 650 A G 0.194 Neutral PMS2 P54278 A650H 650 A H 0.472 Neutral PMS2 P54278 A650I 650 A I 0.672 Pathogenic PMS2 P54278 A650K 650 A K 0.594 Pathogenic PMS2 P54278 A650L 650 A L 0.656 Pathogenic PMS2 P54278 A650M 650 A M 0.49 Neutral PMS2 P54278 A650N 650 A N 0.49 Neutral PMS2 P54278 A650P 650 A P 0.466 Neutral PMS2 P54278 A650Q 650 A Q 0.472 Neutral PMS2 P54278 A650R 650 A R 0.586 Pathogenic PMS2 P54278 A650S 650 A S 0.22 Neutral PMS2 P54278 A650T 650 A T 0.288 Neutral PMS2 P54278 A650V 650 A V 0.382 Neutral PMS2 P54278 A650W 650 A W 0.758 Pathogenic PMS2 P54278 A650Y 650 A Y 0.762 Pathogenic PMS2 P54278 K651A 651 K A 0.082 Neutral PMS2 P54278 K651C 651 K C 0.054 Neutral PMS2 P54278 K651D 651 K D 0.058 Neutral PMS2 P54278 K651E 651 K E 0.104 Neutral PMS2 P54278 K651F 651 K F 0.35 Neutral PMS2 P54278 K651G 651 K G 0.176 Neutral PMS2 P54278 K651H 651 K H 0.08 Neutral PMS2 P54278 K651I 651 K I 0.338 Neutral PMS2 P54278 K651L 651 K L 0.286 Neutral PMS2 P54278 K651M 651 K M 0.05 Neutral PMS2 P54278 K651N 651 K N 0.062 Neutral PMS2 P54278 K651P 651 K P 0.372 Neutral PMS2 P54278 K651Q 651 K Q 0.124 Neutral PMS2 P54278 K651R 651 K R 0.008 Neutral PMS2 P54278 K651S 651 K S 0.272 Neutral PMS2 P54278 K651T 651 K T 0.136 Neutral PMS2 P54278 K651V 651 K V 0.286 Neutral PMS2 P54278 K651W 651 K W 0.662 Pathogenic PMS2 P54278 K651Y 651 K Y 0.568 Pathogenic PMS2 P54278 I652A 652 I A 0.118 Neutral PMS2 P54278 I652C 652 I C 0.15 Neutral PMS2 P54278 I652D 652 I D 0.254 Neutral PMS2 P54278 I652E 652 I E 0.224 Neutral PMS2 P54278 I652F 652 I F 0.356 Neutral PMS2 P54278 I652G 652 I G 0.288 Neutral PMS2 P54278 I652H 652 I H 0.156 Neutral PMS2 P54278 I652K 652 I K 0.23 Neutral PMS2 P54278 I652L 652 I L 0.074 Neutral PMS2 P54278 I652M 652 I M 0.176 Neutral PMS2 P54278 I652N 652 I N 0.27 Neutral PMS2 P54278 I652P 652 I P 0.262 Neutral PMS2 P54278 I652Q 652 I Q 0.288 Neutral PMS2 P54278 I652R 652 I R 0.482 Neutral PMS2 P54278 I652S 652 I S 0.326 Neutral PMS2 P54278 I652T 652 I T 0.176 Neutral PMS2 P54278 I652V 652 I V 0.234 Neutral PMS2 P54278 I652W 652 I W 0.552 Pathogenic PMS2 P54278 I652Y 652 I Y 0.51 Pathogenic PMS2 P54278 C653A 653 C A 0.072 Neutral PMS2 P54278 C653D 653 C D 0.022 Neutral PMS2 P54278 C653E 653 C E 0.132 Neutral PMS2 P54278 C653F 653 C F 0.418 Neutral PMS2 P54278 C653G 653 C G 0.162 Neutral PMS2 P54278 C653H 653 C H 0.236 Neutral PMS2 P54278 C653I 653 C I 0.352 Neutral PMS2 P54278 C653K 653 C K 0.22 Neutral PMS2 P54278 C653L 653 C L 0.31 Neutral PMS2 P54278 C653M 653 C M 0.146 Neutral PMS2 P54278 C653N 653 C N 0 Neutral PMS2 P54278 C653P 653 C P 0.276 Neutral PMS2 P54278 C653Q 653 C Q 0.146 Neutral PMS2 P54278 C653R 653 C R 0.27 Neutral PMS2 P54278 C653S 653 C S 0.014 Neutral PMS2 P54278 C653T 653 C T 0.144 Neutral PMS2 P54278 C653V 653 C V 0.198 Neutral PMS2 P54278 C653W 653 C W 0.492 Neutral PMS2 P54278 C653Y 653 C Y 0.448 Neutral PMS2 P54278 P654A 654 P A 0.252 Neutral PMS2 P54278 P654C 654 P C 0.246 Neutral PMS2 P54278 P654D 654 P D 0.14 Neutral PMS2 P54278 P654E 654 P E 0.374 Neutral PMS2 P54278 P654F 654 P F 0.482 Neutral PMS2 P54278 P654G 654 P G 0.14 Neutral PMS2 P54278 P654H 654 P H 0.448 Neutral PMS2 P54278 P654I 654 P I 0.084 Neutral PMS2 P54278 P654K 654 P K 0.368 Neutral PMS2 P54278 P654L 654 P L 0.202 Neutral PMS2 P54278 P654M 654 P M 0.392 Neutral PMS2 P54278 P654N 654 P N 0.11 Neutral PMS2 P54278 P654Q 654 P Q 0.376 Neutral PMS2 P54278 P654R 654 P R 0.434 Neutral PMS2 P54278 P654S 654 P S 0.176 Neutral PMS2 P54278 P654T 654 P T 0.264 Neutral PMS2 P54278 P654V 654 P V 0.268 Neutral PMS2 P54278 P654W 654 P W 0.624 Pathogenic PMS2 P54278 P654Y 654 P Y 0.556 Pathogenic PMS2 P54278 G655A 655 G A 0.166 Neutral PMS2 P54278 G655C 655 G C 0.37 Neutral PMS2 P54278 G655D 655 G D 0.328 Neutral PMS2 P54278 G655E 655 G E 0.344 Neutral PMS2 P54278 G655F 655 G F 0.772 Pathogenic PMS2 P54278 G655H 655 G H 0.716 Pathogenic PMS2 P54278 G655I 655 G I 0.688 Pathogenic PMS2 P54278 G655K 655 G K 0.64 Pathogenic PMS2 P54278 G655L 655 G L 0.69 Pathogenic PMS2 P54278 G655M 655 G M 0.618 Pathogenic PMS2 P54278 G655N 655 G N 0.428 Neutral PMS2 P54278 G655P 655 G P 0.646 Pathogenic PMS2 P54278 G655Q 655 G Q 0.368 Neutral PMS2 P54278 G655R 655 G R 0.646 Pathogenic PMS2 P54278 G655S 655 G S 0.296 Neutral PMS2 P54278 G655T 655 G T 0.486 Neutral PMS2 P54278 G655V 655 G V 0.668 Pathogenic PMS2 P54278 G655W 655 G W 0.77 Pathogenic PMS2 P54278 G655Y 655 G Y 0.754 Pathogenic PMS2 P54278 E656A 656 E A 0.172 Neutral PMS2 P54278 E656C 656 E C 0.118 Neutral PMS2 P54278 E656D 656 E D 0.006 Neutral PMS2 P54278 E656F 656 E F 0.422 Neutral PMS2 P54278 E656G 656 E G 0.078 Neutral PMS2 P54278 E656H 656 E H 0.17 Neutral PMS2 P54278 E656I 656 E I 0.444 Neutral PMS2 P54278 E656K 656 E K 0.276 Neutral PMS2 P54278 E656L 656 E L 0.442 Neutral PMS2 P54278 E656M 656 E M 0.122 Neutral PMS2 P54278 E656N 656 E N 0.086 Neutral PMS2 P54278 E656P 656 E P 0.454 Neutral PMS2 P54278 E656Q 656 E Q 0.02 Neutral PMS2 P54278 E656R 656 E R 0.118 Neutral PMS2 P54278 E656S 656 E S 0.224 Neutral PMS2 P54278 E656T 656 E T 0.246 Neutral PMS2 P54278 E656V 656 E V 0.392 Neutral PMS2 P54278 E656W 656 E W 0.696 Pathogenic PMS2 P54278 E656Y 656 E Y 0.58 Pathogenic PMS2 P54278 N657A 657 N A 0.184 Neutral PMS2 P54278 N657C 657 N C 0.254 Neutral PMS2 P54278 N657D 657 N D 0.154 Neutral PMS2 P54278 N657E 657 N E 0.17 Neutral PMS2 P54278 N657F 657 N F 0.446 Neutral PMS2 P54278 N657G 657 N G 0.228 Neutral PMS2 P54278 N657H 657 N H 0.414 Neutral PMS2 P54278 N657I 657 N I 0.514 Pathogenic PMS2 P54278 N657K 657 N K 0.376 Neutral PMS2 P54278 N657L 657 N L 0.248 Neutral PMS2 P54278 N657M 657 N M 0.38 Neutral PMS2 P54278 N657P 657 N P 0.404 Neutral PMS2 P54278 N657Q 657 N Q 0.196 Neutral PMS2 P54278 N657R 657 N R 0.318 Neutral PMS2 P54278 N657S 657 N S 0.032 Neutral PMS2 P54278 N657T 657 N T 0.196 Neutral PMS2 P54278 N657V 657 N V 0.458 Neutral PMS2 P54278 N657W 657 N W 0.728 Pathogenic PMS2 P54278 N657Y 657 N Y 0.682 Pathogenic PMS2 P54278 Q658A 658 Q A 0.116 Neutral PMS2 P54278 Q658C 658 Q C 0.098 Neutral PMS2 P54278 Q658D 658 Q D 0.096 Neutral PMS2 P54278 Q658E 658 Q E 0.098 Neutral PMS2 P54278 Q658F 658 Q F 0.424 Neutral PMS2 P54278 Q658G 658 Q G 0.126 Neutral PMS2 P54278 Q658H 658 Q H 0.298 Neutral PMS2 P54278 Q658I 658 Q I 0.416 Neutral PMS2 P54278 Q658K 658 Q K 0.022 Neutral PMS2 P54278 Q658L 658 Q L 0.382 Neutral PMS2 P54278 Q658M 658 Q M 0.226 Neutral PMS2 P54278 Q658N 658 Q N 0.086 Neutral PMS2 P54278 Q658P 658 Q P 0.346 Neutral PMS2 P54278 Q658R 658 Q R 0.07 Neutral PMS2 P54278 Q658S 658 Q S 0.116 Neutral PMS2 P54278 Q658T 658 Q T 0.158 Neutral PMS2 P54278 Q658V 658 Q V 0.318 Neutral PMS2 P54278 Q658W 658 Q W 0.53 Pathogenic PMS2 P54278 Q658Y 658 Q Y 0.468 Neutral PMS2 P54278 A659C 659 A C 0.192 Neutral PMS2 P54278 A659D 659 A D 0.338 Neutral PMS2 P54278 A659E 659 A E 0.302 Neutral PMS2 P54278 A659F 659 A F 0.48 Neutral PMS2 P54278 A659G 659 A G 0.162 Neutral PMS2 P54278 A659H 659 A H 0.314 Neutral PMS2 P54278 A659I 659 A I 0.418 Neutral PMS2 P54278 A659K 659 A K 0.366 Neutral PMS2 P54278 A659L 659 A L 0.324 Neutral PMS2 P54278 A659M 659 A M 0.3 Neutral PMS2 P54278 A659N 659 A N 0.316 Neutral PMS2 P54278 A659P 659 A P 0.288 Neutral PMS2 P54278 A659Q 659 A Q 0.284 Neutral PMS2 P54278 A659R 659 A R 0.344 Neutral PMS2 P54278 A659S 659 A S 0.008 Neutral PMS2 P54278 A659T 659 A T 0.016 Neutral PMS2 P54278 A659V 659 A V 0.046 Neutral PMS2 P54278 A659W 659 A W 0.514 Pathogenic PMS2 P54278 A659Y 659 A Y 0.512 Pathogenic PMS2 P54278 I66A 66 I A 0.108 Neutral PMS2 P54278 I66C 66 I C 0.328 Neutral PMS2 P54278 I66D 66 I D 0.762 Pathogenic PMS2 P54278 I66E 66 I E 0.766 Pathogenic PMS2 P54278 I66F 66 I F 0.3 Neutral PMS2 P54278 I66G 66 I G 0.81 Pathogenic PMS2 P54278 I66H 66 I H 0.842 Pathogenic PMS2 P54278 I66K 66 I K 0.5 Pathogenic PMS2 P54278 I66L 66 I L 0.084 Neutral PMS2 P54278 I66M 66 I M 0.18 Neutral PMS2 P54278 I66N 66 I N 0.788 Pathogenic PMS2 P54278 I66P 66 I P 0.944 Pathogenic PMS2 P54278 I66Q 66 I Q 0.798 Pathogenic PMS2 P54278 I66R 66 I R 0.882 Pathogenic PMS2 P54278 I66S 66 I S 0.628 Pathogenic PMS2 P54278 I66T 66 I T 0.278 Neutral PMS2 P54278 I66V 66 I V 0.132 Neutral PMS2 P54278 I66W 66 I W 0.988 Pathogenic PMS2 P54278 I66Y 66 I Y 0.984 Pathogenic PMS2 P54278 A660C 660 A C 0.332 Neutral PMS2 P54278 A660D 660 A D 0.528 Pathogenic PMS2 P54278 A660E 660 A E 0.506 Pathogenic PMS2 P54278 A660F 660 A F 0.662 Pathogenic PMS2 P54278 A660G 660 A G 0.092 Neutral PMS2 P54278 A660H 660 A H 0.472 Neutral PMS2 P54278 A660I 660 A I 0.672 Pathogenic PMS2 P54278 A660K 660 A K 0.594 Pathogenic PMS2 P54278 A660L 660 A L 0.656 Pathogenic PMS2 P54278 A660M 660 A M 0.49 Neutral PMS2 P54278 A660N 660 A N 0.464 Neutral PMS2 P54278 A660P 660 A P 0.466 Neutral PMS2 P54278 A660Q 660 A Q 0.39 Neutral PMS2 P54278 A660R 660 A R 0.55 Pathogenic PMS2 P54278 A660S 660 A S 0.166 Neutral PMS2 P54278 A660T 660 A T 0.272 Neutral PMS2 P54278 A660V 660 A V 0.382 Neutral PMS2 P54278 A660W 660 A W 0.758 Pathogenic PMS2 P54278 A660Y 660 A Y 0.762 Pathogenic PMS2 P54278 E661A 661 E A 0.184 Neutral PMS2 P54278 E661C 661 E C 0.13 Neutral PMS2 P54278 E661D 661 E D 0.142 Neutral PMS2 P54278 E661F 661 E F 0.138 Neutral PMS2 P54278 E661G 661 E G 0.086 Neutral PMS2 P54278 E661H 661 E H 0.18 Neutral PMS2 P54278 E661I 661 E I 0.464 Neutral PMS2 P54278 E661K 661 E K 0.294 Neutral PMS2 P54278 E661L 661 E L 0.462 Neutral PMS2 P54278 E661M 661 E M 0.126 Neutral PMS2 P54278 E661N 661 E N 0.056 Neutral PMS2 P54278 E661P 661 E P 0.474 Neutral PMS2 P54278 E661Q 661 E Q 0.092 Neutral PMS2 P54278 E661R 661 E R 0.102 Neutral PMS2 P54278 E661S 661 E S 0.24 Neutral PMS2 P54278 E661T 661 E T 0.26 Neutral PMS2 P54278 E661V 661 E V 0.382 Neutral PMS2 P54278 E661W 661 E W 0.712 Pathogenic PMS2 P54278 E661Y 661 E Y 0.598 Pathogenic PMS2 P54278 D662A 662 D A 0.014 Neutral PMS2 P54278 D662C 662 D C 0.156 Neutral PMS2 P54278 D662E 662 D E 0.018 Neutral PMS2 P54278 D662F 662 D F 0.462 Neutral PMS2 P54278 D662G 662 D G 0.172 Neutral PMS2 P54278 D662H 662 D H 0.098 Neutral PMS2 P54278 D662I 662 D I 0.236 Neutral PMS2 P54278 D662K 662 D K 0.222 Neutral PMS2 P54278 D662L 662 D L 0.294 Neutral PMS2 P54278 D662M 662 D M 0.216 Neutral PMS2 P54278 D662N 662 D N 0.02 Neutral PMS2 P54278 D662P 662 D P 0.318 Neutral PMS2 P54278 D662Q 662 D Q 0.116 Neutral PMS2 P54278 D662R 662 D R 0.188 Neutral PMS2 P54278 D662S 662 D S 0.198 Neutral PMS2 P54278 D662T 662 D T 0.12 Neutral PMS2 P54278 D662V 662 D V 0.272 Neutral PMS2 P54278 D662W 662 D W 0.528 Pathogenic PMS2 P54278 D662Y 662 D Y 0.498 Neutral PMS2 P54278 E663A 663 E A 0.182 Neutral PMS2 P54278 E663C 663 E C 0.126 Neutral PMS2 P54278 E663D 663 E D 0.14 Neutral PMS2 P54278 E663F 663 E F 0.436 Neutral PMS2 P54278 E663G 663 E G 0.082 Neutral PMS2 P54278 E663H 663 E H 0.176 Neutral PMS2 P54278 E663I 663 E I 0.496 Neutral PMS2 P54278 E663K 663 E K 0.29 Neutral PMS2 P54278 E663L 663 E L 0.112 Neutral PMS2 P54278 E663M 663 E M 0.298 Neutral PMS2 P54278 E663N 663 E N 0.092 Neutral PMS2 P54278 E663P 663 E P 0.184 Neutral PMS2 P54278 E663Q 663 E Q 0.09 Neutral PMS2 P54278 E663R 663 E R 0.126 Neutral PMS2 P54278 E663S 663 E S 0.236 Neutral PMS2 P54278 E663T 663 E T 0.224 Neutral PMS2 P54278 E663V 663 E V 0.096 Neutral PMS2 P54278 E663W 663 E W 0.708 Pathogenic PMS2 P54278 E663Y 663 E Y 0.594 Pathogenic PMS2 P54278 L664A 664 L A 0.032 Neutral PMS2 P54278 L664C 664 L C 0.138 Neutral PMS2 P54278 L664D 664 L D 0.244 Neutral PMS2 P54278 L664E 664 L E 0.236 Neutral PMS2 P54278 L664F 664 L F 0.378 Neutral PMS2 P54278 L664G 664 L G 0.168 Neutral PMS2 P54278 L664H 664 L H 0.13 Neutral PMS2 P54278 L664I 664 L I 0.124 Neutral PMS2 P54278 L664K 664 L K 0.186 Neutral PMS2 P54278 L664M 664 L M 0.196 Neutral PMS2 P54278 L664N 664 L N 0.246 Neutral PMS2 P54278 L664P 664 L P 0.36 Neutral PMS2 P54278 L664Q 664 L Q 0.084 Neutral PMS2 P54278 L664R 664 L R 0.508 Pathogenic PMS2 P54278 L664S 664 L S 0.202 Neutral PMS2 P54278 L664T 664 L T 0.252 Neutral PMS2 P54278 L664V 664 L V 0.244 Neutral PMS2 P54278 L664W 664 L W 0.54 Pathogenic PMS2 P54278 L664Y 664 L Y 0.502 Pathogenic PMS2 P54278 R665A 665 R A 0.134 Neutral PMS2 P54278 R665C 665 R C 0.226 Neutral PMS2 P54278 R665D 665 R D 0.244 Neutral PMS2 P54278 R665E 665 R E 0.184 Neutral PMS2 P54278 R665F 665 R F 0.412 Neutral PMS2 P54278 R665G 665 R G 0.046 Neutral PMS2 P54278 R665H 665 R H 0.176 Neutral PMS2 P54278 R665I 665 R I 0.44 Neutral PMS2 P54278 R665K 665 R K 0.008 Neutral PMS2 P54278 R665L 665 R L 0.356 Neutral PMS2 P54278 R665M 665 R M 0.242 Neutral PMS2 P54278 R665N 665 R N 0.252 Neutral PMS2 P54278 R665P 665 R P 0.392 Neutral PMS2 P54278 R665Q 665 R Q 0.216 Neutral PMS2 P54278 R665S 665 R S 0.074 Neutral PMS2 P54278 R665T 665 R T 0.202 Neutral PMS2 P54278 R665V 665 R V 0.282 Neutral PMS2 P54278 R665W 665 R W 0.59 Pathogenic PMS2 P54278 R665Y 665 R Y 0.426 Neutral PMS2 P54278 K666A 666 K A 0.082 Neutral PMS2 P54278 K666C 666 K C 0.054 Neutral PMS2 P54278 K666D 666 K D 0.094 Neutral PMS2 P54278 K666E 666 K E 0.104 Neutral PMS2 P54278 K666F 666 K F 0.35 Neutral PMS2 P54278 K666G 666 K G 0.176 Neutral PMS2 P54278 K666H 666 K H 0.08 Neutral PMS2 P54278 K666I 666 K I 0.338 Neutral PMS2 P54278 K666L 666 K L 0.16 Neutral PMS2 P54278 K666M 666 K M 0.184 Neutral PMS2 P54278 K666N 666 K N 0.116 Neutral PMS2 P54278 K666P 666 K P 0.372 Neutral PMS2 P54278 K666Q 666 K Q 0.034 Neutral PMS2 P54278 K666R 666 K R 0.028 Neutral PMS2 P54278 K666S 666 K S 0.02 Neutral PMS2 P54278 K666T 666 K T 0.23 Neutral PMS2 P54278 K666V 666 K V 0.286 Neutral PMS2 P54278 K666W 666 K W 0.662 Pathogenic PMS2 P54278 K666Y 666 K Y 0.568 Pathogenic PMS2 P54278 E667A 667 E A 0.178 Neutral PMS2 P54278 E667C 667 E C 0.118 Neutral PMS2 P54278 E667D 667 E D 0.068 Neutral PMS2 P54278 E667F 667 E F 0.468 Neutral PMS2 P54278 E667G 667 E G 0.108 Neutral PMS2 P54278 E667H 667 E H 0.24 Neutral PMS2 P54278 E667I 667 E I 0.482 Neutral PMS2 P54278 E667K 667 E K 0.104 Neutral PMS2 P54278 E667L 667 E L 0.444 Neutral PMS2 P54278 E667M 667 E M 0.282 Neutral PMS2 P54278 E667N 667 E N 0.086 Neutral PMS2 P54278 E667P 667 E P 0.454 Neutral PMS2 P54278 E667Q 667 E Q 0.084 Neutral PMS2 P54278 E667R 667 E R 0.118 Neutral PMS2 P54278 E667S 667 E S 0.22 Neutral PMS2 P54278 E667T 667 E T 0.216 Neutral PMS2 P54278 E667V 667 E V 0.362 Neutral PMS2 P54278 E667W 667 E W 0.696 Pathogenic PMS2 P54278 E667Y 667 E Y 0.58 Pathogenic PMS2 P54278 I668A 668 I A 0.094 Neutral PMS2 P54278 I668C 668 I C 0.14 Neutral PMS2 P54278 I668D 668 I D 0.116 Neutral PMS2 P54278 I668E 668 I E 0.208 Neutral PMS2 P54278 I668F 668 I F 0.344 Neutral PMS2 P54278 I668G 668 I G 0.278 Neutral PMS2 P54278 I668H 668 I H 0.146 Neutral PMS2 P54278 I668K 668 I K 0.238 Neutral PMS2 P54278 I668L 668 I L 0.202 Neutral PMS2 P54278 I668M 668 I M 0.166 Neutral PMS2 P54278 I668N 668 I N 0.188 Neutral PMS2 P54278 I668P 668 I P 0.252 Neutral PMS2 P54278 I668Q 668 I Q 0.258 Neutral PMS2 P54278 I668R 668 I R 0.47 Neutral PMS2 P54278 I668S 668 I S 0.158 Neutral PMS2 P54278 I668T 668 I T 0.164 Neutral PMS2 P54278 I668V 668 I V 0.22 Neutral PMS2 P54278 I668W 668 I W 0.538 Pathogenic PMS2 P54278 I668Y 668 I Y 0.496 Neutral PMS2 P54278 S669A 669 S A 0.068 Neutral PMS2 P54278 S669C 669 S C 0.058 Neutral PMS2 P54278 S669D 669 S D 0.004 Neutral PMS2 P54278 S669E 669 S E 0.288 Neutral PMS2 P54278 S669F 669 S F 0.456 Neutral PMS2 P54278 S669G 669 S G 0.094 Neutral PMS2 P54278 S669H 669 S H 0.392 Neutral PMS2 P54278 S669I 669 S I 0.2 Neutral PMS2 P54278 S669K 669 S K 0.272 Neutral PMS2 P54278 S669L 669 S L 0.138 Neutral PMS2 P54278 S669M 669 S M 0.534 Pathogenic PMS2 P54278 S669N 669 S N 0.072 Neutral PMS2 P54278 S669P 669 S P 0.178 Neutral PMS2 P54278 S669Q 669 S Q 0.286 Neutral PMS2 P54278 S669R 669 S R 0.212 Neutral PMS2 P54278 S669T 669 S T 0.142 Neutral PMS2 P54278 S669V 669 S V 0.324 Neutral PMS2 P54278 S669W 669 S W 0.658 Pathogenic PMS2 P54278 S669Y 669 S Y 0.592 Pathogenic PMS2 P54278 E67A 67 E A 0.706 Pathogenic PMS2 P54278 E67C 67 E C 0.648 Pathogenic PMS2 P54278 E67D 67 E D 0.756 Pathogenic PMS2 P54278 E67F 67 E F 0.962 Pathogenic PMS2 P54278 E67G 67 E G 0.238 Neutral PMS2 P54278 E67H 67 E H 0.858 Pathogenic PMS2 P54278 E67I 67 E I 0.982 Pathogenic PMS2 P54278 E67K 67 E K 0.338 Neutral PMS2 P54278 E67L 67 E L 0.978 Pathogenic PMS2 P54278 E67M 67 E M 0.91 Pathogenic PMS2 P54278 E67N 67 E N 0.634 Pathogenic PMS2 P54278 E67P 67 E P 0.93 Pathogenic PMS2 P54278 E67Q 67 E Q 0.074 Neutral PMS2 P54278 E67R 67 E R 0.836 Pathogenic PMS2 P54278 E67S 67 E S 0.164 Neutral PMS2 P54278 E67T 67 E T 0.18 Neutral PMS2 P54278 E67V 67 E V 0.92 Pathogenic PMS2 P54278 E67W 67 E W 0.986 Pathogenic PMS2 P54278 E67Y 67 E Y 0.966 Pathogenic PMS2 P54278 K670A 670 K A 0.106 Neutral PMS2 P54278 K670C 670 K C 0.062 Neutral PMS2 P54278 K670D 670 K D 0.102 Neutral PMS2 P54278 K670E 670 K E 0.038 Neutral PMS2 P54278 K670F 670 K F 0.368 Neutral PMS2 P54278 K670G 670 K G 0.182 Neutral PMS2 P54278 K670H 670 K H 0.086 Neutral PMS2 P54278 K670I 670 K I 0.4 Neutral PMS2 P54278 K670L 670 K L 0.086 Neutral PMS2 P54278 K670M 670 K M 0.194 Neutral PMS2 P54278 K670N 670 K N 0.124 Neutral PMS2 P54278 K670P 670 K P 0.392 Neutral PMS2 P54278 K670Q 670 K Q 0.132 Neutral PMS2 P54278 K670R 670 K R 0.12 Neutral PMS2 P54278 K670S 670 K S 0.288 Neutral PMS2 P54278 K670T 670 K T 0.15 Neutral PMS2 P54278 K670V 670 K V 0.172 Neutral PMS2 P54278 K670W 670 K W 0.682 Pathogenic PMS2 P54278 K670Y 670 K Y 0.586 Pathogenic PMS2 P54278 T671A 671 T A 0 Neutral PMS2 P54278 T671C 671 T C 0.064 Neutral PMS2 P54278 T671D 671 T D 0.02 Neutral PMS2 P54278 T671E 671 T E 0.024 Neutral PMS2 P54278 T671F 671 T F 0.186 Neutral PMS2 P54278 T671G 671 T G 0.058 Neutral PMS2 P54278 T671H 671 T H 0.084 Neutral PMS2 P54278 T671I 671 T I 0.066 Neutral PMS2 P54278 T671K 671 T K 0.042 Neutral PMS2 P54278 T671L 671 T L 0.074 Neutral PMS2 P54278 T671M 671 T M 0.098 Neutral PMS2 P54278 T671N 671 T N 0.052 Neutral PMS2 P54278 T671P 671 T P 0.056 Neutral PMS2 P54278 T671Q 671 T Q 0.01 Neutral PMS2 P54278 T671R 671 T R 0.26 Neutral PMS2 P54278 T671S 671 T S 0 Neutral PMS2 P54278 T671V 671 T V 0.206 Neutral PMS2 P54278 T671W 671 T W 0.466 Neutral PMS2 P54278 T671Y 671 T Y 0.424 Neutral PMS2 P54278 M672A 672 M A 0.114 Neutral PMS2 P54278 M672C 672 M C 0.078 Neutral PMS2 P54278 M672D 672 M D 0.246 Neutral PMS2 P54278 M672E 672 M E 0.072 Neutral PMS2 P54278 M672F 672 M F 0.406 Neutral PMS2 P54278 M672G 672 M G 0.172 Neutral PMS2 P54278 M672H 672 M H 0.102 Neutral PMS2 P54278 M672I 672 M I 0.038 Neutral PMS2 P54278 M672K 672 M K 0.17 Neutral PMS2 P54278 M672L 672 M L 0.136 Neutral PMS2 P54278 M672N 672 M N 0.28 Neutral PMS2 P54278 M672P 672 M P 0.364 Neutral PMS2 P54278 M672Q 672 M Q 0.066 Neutral PMS2 P54278 M672R 672 M R 0.278 Neutral PMS2 P54278 M672S 672 M S 0.084 Neutral PMS2 P54278 M672T 672 M T 0.22 Neutral PMS2 P54278 M672V 672 M V 0.206 Neutral PMS2 P54278 M672W 672 M W 0.686 Pathogenic PMS2 P54278 M672Y 672 M Y 0.592 Pathogenic PMS2 P54278 F673A 673 F A 0.124 Neutral PMS2 P54278 F673C 673 F C 0.13 Neutral PMS2 P54278 F673D 673 F D 0.246 Neutral PMS2 P54278 F673E 673 F E 0.28 Neutral PMS2 P54278 F673G 673 F G 0.192 Neutral PMS2 P54278 F673H 673 F H 0.074 Neutral PMS2 P54278 F673I 673 F I 0 Neutral PMS2 P54278 F673K 673 F K 0.25 Neutral PMS2 P54278 F673L 673 F L 0.108 Neutral PMS2 P54278 F673M 673 F M 0.124 Neutral PMS2 P54278 F673N 673 F N 0.256 Neutral PMS2 P54278 F673P 673 F P 0.278 Neutral PMS2 P54278 F673Q 673 F Q 0.256 Neutral PMS2 P54278 F673R 673 F R 0.118 Neutral PMS2 P54278 F673S 673 F S 0.22 Neutral PMS2 P54278 F673T 673 F T 0.236 Neutral PMS2 P54278 F673V 673 F V 0.28 Neutral PMS2 P54278 F673W 673 F W 0.468 Neutral PMS2 P54278 F673Y 673 F Y 0.174 Neutral PMS2 P54278 A674C 674 A C 0.354 Neutral PMS2 P54278 A674D 674 A D 0.478 Neutral PMS2 P54278 A674E 674 A E 0.478 Neutral PMS2 P54278 A674F 674 A F 0.708 Pathogenic PMS2 P54278 A674G 674 A G 0.188 Neutral PMS2 P54278 A674H 674 A H 0.5 Pathogenic PMS2 P54278 A674I 674 A I 0.698 Pathogenic PMS2 P54278 A674K 674 A K 0.366 Neutral PMS2 P54278 A674L 674 A L 0.492 Neutral PMS2 P54278 A674M 674 A M 0.486 Neutral PMS2 P54278 A674N 674 A N 0.458 Neutral PMS2 P54278 A674P 674 A P 0.452 Neutral PMS2 P54278 A674Q 674 A Q 0.486 Neutral PMS2 P54278 A674R 674 A R 0.572 Pathogenic PMS2 P54278 A674S 674 A S 0.162 Neutral PMS2 P54278 A674T 674 A T 0.284 Neutral PMS2 P54278 A674V 674 A V 0.366 Neutral PMS2 P54278 A674W 674 A W 0.738 Pathogenic PMS2 P54278 A674Y 674 A Y 0.724 Pathogenic PMS2 P54278 E675A 675 E A 0.122 Neutral PMS2 P54278 E675C 675 E C 0.068 Neutral PMS2 P54278 E675D 675 E D 0 Neutral PMS2 P54278 E675F 675 E F 0.336 Neutral PMS2 P54278 E675G 675 E G 0.084 Neutral PMS2 P54278 E675H 675 E H 0.164 Neutral PMS2 P54278 E675I 675 E I 0.306 Neutral PMS2 P54278 E675K 675 E K 0.002 Neutral PMS2 P54278 E675L 675 E L 0.15 Neutral PMS2 P54278 E675M 675 E M 0.172 Neutral PMS2 P54278 E675N 675 E N 0.056 Neutral PMS2 P54278 E675P 675 E P 0.318 Neutral PMS2 P54278 E675Q 675 E Q 0 Neutral PMS2 P54278 E675R 675 E R 0.048 Neutral PMS2 P54278 E675S 675 E S 0.17 Neutral PMS2 P54278 E675T 675 E T 0.144 Neutral PMS2 P54278 E675V 675 E V 0.266 Neutral PMS2 P54278 E675W 675 E W 0.478 Neutral PMS2 P54278 E675Y 675 E Y 0.38 Neutral PMS2 P54278 M676A 676 M A 0.114 Neutral PMS2 P54278 M676C 676 M C 0.078 Neutral PMS2 P54278 M676D 676 M D 0.24 Neutral PMS2 P54278 M676E 676 M E 0.044 Neutral PMS2 P54278 M676F 676 M F 0.362 Neutral PMS2 P54278 M676G 676 M G 0.172 Neutral PMS2 P54278 M676H 676 M H 0.034 Neutral PMS2 P54278 M676I 676 M I 0.158 Neutral PMS2 P54278 M676K 676 M K 0.17 Neutral PMS2 P54278 M676L 676 M L 0.034 Neutral PMS2 P54278 M676N 676 M N 0.28 Neutral PMS2 P54278 M676P 676 M P 0.186 Neutral PMS2 P54278 M676Q 676 M Q 0.066 Neutral PMS2 P54278 M676R 676 M R 0.278 Neutral PMS2 P54278 M676S 676 M S 0.236 Neutral PMS2 P54278 M676T 676 M T 0.22 Neutral PMS2 P54278 M676V 676 M V 0.206 Neutral PMS2 P54278 M676W 676 M W 0.686 Pathogenic PMS2 P54278 M676Y 676 M Y 0.592 Pathogenic PMS2 P54278 E677A 677 E A 0.14 Neutral PMS2 P54278 E677C 677 E C 0.122 Neutral PMS2 P54278 E677D 677 E D 0.016 Neutral PMS2 P54278 E677F 677 E F 0.422 Neutral PMS2 P54278 E677G 677 E G 0.114 Neutral PMS2 P54278 E677H 677 E H 0.242 Neutral PMS2 P54278 E677I 677 E I 0.48 Neutral PMS2 P54278 E677K 677 E K 0.274 Neutral PMS2 P54278 E677L 677 E L 0.444 Neutral PMS2 P54278 E677M 677 E M 0.282 Neutral PMS2 P54278 E677N 677 E N 0.092 Neutral PMS2 P54278 E677P 677 E P 0.454 Neutral PMS2 P54278 E677Q 677 E Q 0.03 Neutral PMS2 P54278 E677R 677 E R 0.122 Neutral PMS2 P54278 E677S 677 E S 0.222 Neutral PMS2 P54278 E677T 677 E T 0.244 Neutral PMS2 P54278 E677V 677 E V 0.36 Neutral PMS2 P54278 E677W 677 E W 0.694 Pathogenic PMS2 P54278 E677Y 677 E Y 0.578 Pathogenic PMS2 P54278 I678A 678 I A 0.03 Neutral PMS2 P54278 I678C 678 I C 0.122 Neutral PMS2 P54278 I678D 678 I D 0.118 Neutral PMS2 P54278 I678E 678 I E 0.21 Neutral PMS2 P54278 I678F 678 I F 0.344 Neutral PMS2 P54278 I678G 678 I G 0.28 Neutral PMS2 P54278 I678H 678 I H 0.15 Neutral PMS2 P54278 I678K 678 I K 0.224 Neutral PMS2 P54278 I678L 678 I L 0.204 Neutral PMS2 P54278 I678M 678 I M 0.17 Neutral PMS2 P54278 I678N 678 I N 0.26 Neutral PMS2 P54278 I678P 678 I P 0.254 Neutral PMS2 P54278 I678Q 678 I Q 0.258 Neutral PMS2 P54278 I678R 678 I R 0.472 Neutral PMS2 P54278 I678S 678 I S 0.1 Neutral PMS2 P54278 I678T 678 I T 0.248 Neutral PMS2 P54278 I678V 678 I V 0.03 Neutral PMS2 P54278 I678W 678 I W 0.536 Pathogenic PMS2 P54278 I678Y 678 I Y 0.494 Neutral PMS2 P54278 I679A 679 I A 0.072 Neutral PMS2 P54278 I679C 679 I C 0.092 Neutral PMS2 P54278 I679D 679 I D 0.032 Neutral PMS2 P54278 I679E 679 I E 0.144 Neutral PMS2 P54278 I679F 679 I F 0.234 Neutral PMS2 P54278 I679G 679 I G 0.234 Neutral PMS2 P54278 I679H 679 I H 0.01 Neutral PMS2 P54278 I679K 679 I K 0.162 Neutral PMS2 P54278 I679L 679 I L 0 Neutral PMS2 P54278 I679M 679 I M 0.116 Neutral PMS2 P54278 I679N 679 I N 0.186 Neutral PMS2 P54278 I679P 679 I P 0.186 Neutral PMS2 P54278 I679Q 679 I Q 0.206 Neutral PMS2 P54278 I679R 679 I R 0.288 Neutral PMS2 P54278 I679S 679 I S 0.262 Neutral PMS2 P54278 I679T 679 I T 0.114 Neutral PMS2 P54278 I679V 679 I V 0.022 Neutral PMS2 P54278 I679W 679 I W 0.394 Neutral PMS2 P54278 I679Y 679 I Y 0.348 Neutral PMS2 P54278 V68A 68 V A 0.498 Neutral PMS2 P54278 V68C 68 V C 0.792 Pathogenic PMS2 P54278 V68D 68 V D 0.846 Pathogenic PMS2 P54278 V68E 68 V E 0.952 Pathogenic PMS2 P54278 V68F 68 V F 0.932 Pathogenic PMS2 P54278 V68G 68 V G 0.924 Pathogenic PMS2 P54278 V68H 68 V H 0.896 Pathogenic PMS2 P54278 V68I 68 V I 0.374 Neutral PMS2 P54278 V68K 68 V K 0.97 Pathogenic PMS2 P54278 V68L 68 V L 0.946 Pathogenic PMS2 P54278 V68M 68 V M 0.904 Pathogenic PMS2 P54278 V68N 68 V N 0.906 Pathogenic PMS2 P54278 V68P 68 V P 0.98 Pathogenic PMS2 P54278 V68Q 68 V Q 0.288 Neutral PMS2 P54278 V68R 68 V R 0.944 Pathogenic PMS2 P54278 V68S 68 V S 0.8 Pathogenic PMS2 P54278 V68T 68 V T 0.874 Pathogenic PMS2 P54278 V68W 68 V W 0.956 Pathogenic PMS2 P54278 V68Y 68 V Y 0.976 Pathogenic PMS2 P54278 G680A 680 G A 0.152 Neutral PMS2 P54278 G680C 680 G C 0.356 Neutral PMS2 P54278 G680D 680 G D 0.222 Neutral PMS2 P54278 G680E 680 G E 0.346 Neutral PMS2 P54278 G680F 680 G F 0.752 Pathogenic PMS2 P54278 G680H 680 G H 0.624 Pathogenic PMS2 P54278 G680I 680 G I 0.674 Pathogenic PMS2 P54278 G680K 680 G K 0.678 Pathogenic PMS2 P54278 G680L 680 G L 0.678 Pathogenic PMS2 P54278 G680M 680 G M 0.686 Pathogenic PMS2 P54278 G680N 680 G N 0.422 Neutral PMS2 P54278 G680P 680 G P 0.682 Pathogenic PMS2 P54278 G680Q 680 G Q 0.454 Neutral PMS2 P54278 G680R 680 G R 0.738 Pathogenic PMS2 P54278 G680S 680 G S 0.304 Neutral PMS2 P54278 G680T 680 G T 0.412 Neutral PMS2 P54278 G680V 680 G V 0.652 Pathogenic PMS2 P54278 G680W 680 G W 0.544 Pathogenic PMS2 P54278 G680Y 680 G Y 0.734 Pathogenic PMS2 P54278 Q681A 681 Q A 0.132 Neutral PMS2 P54278 Q681C 681 Q C 0.148 Neutral PMS2 P54278 Q681D 681 Q D 0.138 Neutral PMS2 P54278 Q681E 681 Q E 0.042 Neutral PMS2 P54278 Q681F 681 Q F 0.524 Pathogenic PMS2 P54278 Q681G 681 Q G 0.178 Neutral PMS2 P54278 Q681H 681 Q H 0.34 Neutral PMS2 P54278 Q681I 681 Q I 0.43 Neutral PMS2 P54278 Q681K 681 Q K 0.15 Neutral PMS2 P54278 Q681L 681 Q L 0.38 Neutral PMS2 P54278 Q681M 681 Q M 0.314 Neutral PMS2 P54278 Q681N 681 Q N 0.15 Neutral PMS2 P54278 Q681P 681 Q P 0.252 Neutral PMS2 P54278 Q681R 681 Q R 0.134 Neutral PMS2 P54278 Q681S 681 Q S 0.144 Neutral PMS2 P54278 Q681T 681 Q T 0.21 Neutral PMS2 P54278 Q681V 681 Q V 0.414 Neutral PMS2 P54278 Q681W 681 Q W 0.668 Pathogenic PMS2 P54278 Q681Y 681 Q Y 0.598 Pathogenic PMS2 P54278 F682A 682 F A 0.12 Neutral PMS2 P54278 F682C 682 F C 0.122 Neutral PMS2 P54278 F682D 682 F D 0.224 Neutral PMS2 P54278 F682E 682 F E 0.244 Neutral PMS2 P54278 F682G 682 F G 0.18 Neutral PMS2 P54278 F682H 682 F H 0.106 Neutral PMS2 P54278 F682I 682 F I 0.084 Neutral PMS2 P54278 F682K 682 F K 0.232 Neutral PMS2 P54278 F682L 682 F L 0.056 Neutral PMS2 P54278 F682M 682 F M 0.12 Neutral PMS2 P54278 F682N 682 F N 0.236 Neutral PMS2 P54278 F682P 682 F P 0.258 Neutral PMS2 P54278 F682Q 682 F Q 0.224 Neutral PMS2 P54278 F682R 682 F R 0.216 Neutral PMS2 P54278 F682S 682 F S 0.098 Neutral PMS2 P54278 F682T 682 F T 0.106 Neutral PMS2 P54278 F682V 682 F V 0.014 Neutral PMS2 P54278 F682W 682 F W 0.442 Neutral PMS2 P54278 F682Y 682 F Y 0.116 Neutral PMS2 P54278 N683A 683 N A 0.184 Neutral PMS2 P54278 N683C 683 N C 0.254 Neutral PMS2 P54278 N683D 683 N D 0.198 Neutral PMS2 P54278 N683E 683 N E 0.17 Neutral PMS2 P54278 N683F 683 N F 0.446 Neutral PMS2 P54278 N683G 683 N G 0.242 Neutral PMS2 P54278 N683H 683 N H 0.378 Neutral PMS2 P54278 N683I 683 N I 0.444 Neutral PMS2 P54278 N683K 683 N K 0.424 Neutral PMS2 P54278 N683L 683 N L 0.248 Neutral PMS2 P54278 N683M 683 N M 0.38 Neutral PMS2 P54278 N683P 683 N P 0.404 Neutral PMS2 P54278 N683Q 683 N Q 0.02 Neutral PMS2 P54278 N683R 683 N R 0.362 Neutral PMS2 P54278 N683S 683 N S 0.228 Neutral PMS2 P54278 N683T 683 N T 0.196 Neutral PMS2 P54278 N683V 683 N V 0.434 Neutral PMS2 P54278 N683W 683 N W 0.728 Pathogenic PMS2 P54278 N683Y 683 N Y 0.682 Pathogenic PMS2 P54278 L684A 684 L A 0.134 Neutral PMS2 P54278 L684C 684 L C 0.138 Neutral PMS2 P54278 L684D 684 L D 0.244 Neutral PMS2 P54278 L684E 684 L E 0.094 Neutral PMS2 P54278 L684F 684 L F 0.166 Neutral PMS2 P54278 L684G 684 L G 0.268 Neutral PMS2 P54278 L684H 684 L H 0.13 Neutral PMS2 P54278 L684I 684 L I 0.124 Neutral PMS2 P54278 L684K 684 L K 0.186 Neutral PMS2 P54278 L684M 684 L M 0.196 Neutral PMS2 P54278 L684N 684 L N 0.044 Neutral PMS2 P54278 L684P 684 L P 0.348 Neutral PMS2 P54278 L684Q 684 L Q 0.108 Neutral PMS2 P54278 L684R 684 L R 0.508 Pathogenic PMS2 P54278 L684S 684 L S 0.202 Neutral PMS2 P54278 L684T 684 L T 0.182 Neutral PMS2 P54278 L684V 684 L V 0.188 Neutral PMS2 P54278 L684W 684 L W 0.54 Pathogenic PMS2 P54278 L684Y 684 L Y 0.502 Pathogenic PMS2 P54278 G685A 685 G A 0.142 Neutral PMS2 P54278 G685C 685 G C 0.336 Neutral PMS2 P54278 G685D 685 G D 0.412 Neutral PMS2 P54278 G685E 685 G E 0.286 Neutral PMS2 P54278 G685F 685 G F 0.71 Pathogenic PMS2 P54278 G685H 685 G H 0.672 Pathogenic PMS2 P54278 G685I 685 G I 0.65 Pathogenic PMS2 P54278 G685K 685 G K 0.596 Pathogenic PMS2 P54278 G685L 685 G L 0.654 Pathogenic PMS2 P54278 G685M 685 G M 0.574 Pathogenic PMS2 P54278 G685N 685 G N 0.314 Neutral PMS2 P54278 G685P 685 G P 0.614 Pathogenic PMS2 P54278 G685Q 685 G Q 0.278 Neutral PMS2 P54278 G685R 685 G R 0.382 Neutral PMS2 P54278 G685S 685 G S 0.278 Neutral PMS2 P54278 G685T 685 G T 0.45 Neutral PMS2 P54278 G685V 685 G V 0.628 Pathogenic PMS2 P54278 G685W 685 G W 0.716 Pathogenic PMS2 P54278 G685Y 685 G Y 0.714 Pathogenic PMS2 P54278 F686A 686 F A 0.082 Neutral PMS2 P54278 F686C 686 F C 0.122 Neutral PMS2 P54278 F686D 686 F D 0.232 Neutral PMS2 P54278 F686E 686 F E 0.272 Neutral PMS2 P54278 F686G 686 F G 0.186 Neutral PMS2 P54278 F686H 686 F H 0.104 Neutral PMS2 P54278 F686I 686 F I 0.122 Neutral PMS2 P54278 F686K 686 F K 0.258 Neutral PMS2 P54278 F686L 686 F L 0.076 Neutral PMS2 P54278 F686M 686 F M 0.118 Neutral PMS2 P54278 F686N 686 F N 0.066 Neutral PMS2 P54278 F686P 686 F P 0.27 Neutral PMS2 P54278 F686Q 686 F Q 0.248 Neutral PMS2 P54278 F686R 686 F R 0.12 Neutral PMS2 P54278 F686S 686 F S 0.216 Neutral PMS2 P54278 F686T 686 F T 0.226 Neutral PMS2 P54278 F686V 686 F V 0.016 Neutral PMS2 P54278 F686W 686 F W 0.46 Neutral PMS2 P54278 F686Y 686 F Y 0.168 Neutral PMS2 P54278 I687A 687 I A 0.108 Neutral PMS2 P54278 I687C 687 I C 0.116 Neutral PMS2 P54278 I687D 687 I D 0.212 Neutral PMS2 P54278 I687E 687 I E 0.206 Neutral PMS2 P54278 I687F 687 I F 0.334 Neutral PMS2 P54278 I687G 687 I G 0.142 Neutral PMS2 P54278 I687H 687 I H 0.142 Neutral PMS2 P54278 I687K 687 I K 0.218 Neutral PMS2 P54278 I687L 687 I L 0.066 Neutral PMS2 P54278 I687M 687 I M 0.164 Neutral PMS2 P54278 I687N 687 I N 0.25 Neutral PMS2 P54278 I687P 687 I P 0.246 Neutral PMS2 P54278 I687Q 687 I Q 0.268 Neutral PMS2 P54278 I687R 687 I R 0.422 Neutral PMS2 P54278 I687S 687 I S 0.212 Neutral PMS2 P54278 I687T 687 I T 0.24 Neutral PMS2 P54278 I687V 687 I V 0.17 Neutral PMS2 P54278 I687W 687 I W 0.518 Pathogenic PMS2 P54278 I687Y 687 I Y 0.37 Neutral PMS2 P54278 I688A 688 I A 0.072 Neutral PMS2 P54278 I688C 688 I C 0.092 Neutral PMS2 P54278 I688D 688 I D 0.174 Neutral PMS2 P54278 I688E 688 I E 0.08 Neutral PMS2 P54278 I688F 688 I F 0.234 Neutral PMS2 P54278 I688G 688 I G 0.212 Neutral PMS2 P54278 I688H 688 I H 0.088 Neutral PMS2 P54278 I688K 688 I K 0.162 Neutral PMS2 P54278 I688L 688 I L 0.11 Neutral PMS2 P54278 I688M 688 I M 0.116 Neutral PMS2 P54278 I688N 688 I N 0.1 Neutral PMS2 P54278 I688P 688 I P 0.198 Neutral PMS2 P54278 I688Q 688 I Q 0.206 Neutral PMS2 P54278 I688R 688 I R 0.288 Neutral PMS2 P54278 I688S 688 I S 0.262 Neutral PMS2 P54278 I688T 688 I T 0.114 Neutral PMS2 P54278 I688V 688 I V 0 Neutral PMS2 P54278 I688W 688 I W 0.394 Neutral PMS2 P54278 I688Y 688 I Y 0.35 Neutral PMS2 P54278 T689A 689 T A 0 Neutral PMS2 P54278 T689C 689 T C 0.064 Neutral PMS2 P54278 T689D 689 T D 0.04 Neutral PMS2 P54278 T689E 689 T E 0.054 Neutral PMS2 P54278 T689F 689 T F 0.266 Neutral PMS2 P54278 T689G 689 T G 0.036 Neutral PMS2 P54278 T689H 689 T H 0.12 Neutral PMS2 P54278 T689I 689 T I 0.084 Neutral PMS2 P54278 T689K 689 T K 0.048 Neutral PMS2 P54278 T689L 689 T L 0.084 Neutral PMS2 P54278 T689M 689 T M 0.142 Neutral PMS2 P54278 T689N 689 T N 0.052 Neutral PMS2 P54278 T689P 689 T P 0.114 Neutral PMS2 P54278 T689Q 689 T Q 0.02 Neutral PMS2 P54278 T689R 689 T R 0.312 Neutral PMS2 P54278 T689S 689 T S 0 Neutral PMS2 P54278 T689V 689 T V 0.216 Neutral PMS2 P54278 T689W 689 T W 0.536 Pathogenic PMS2 P54278 T689Y 689 T Y 0.492 Neutral PMS2 P54278 S69A 69 S A 0.044 Neutral PMS2 P54278 S69C 69 S C 0.078 Neutral PMS2 P54278 S69D 69 S D 0.582 Pathogenic PMS2 P54278 S69E 69 S E 0.77 Pathogenic PMS2 P54278 S69F 69 S F 0.604 Pathogenic PMS2 P54278 S69G 69 S G 0.404 Neutral PMS2 P54278 S69H 69 S H 0.67 Pathogenic PMS2 P54278 S69I 69 S I 0.382 Neutral PMS2 P54278 S69K 69 S K 0.774 Pathogenic PMS2 P54278 S69L 69 S L 0.548 Pathogenic PMS2 P54278 S69M 69 S M 0.712 Pathogenic PMS2 P54278 S69N 69 S N 0.106 Neutral PMS2 P54278 S69P 69 S P 0.69 Pathogenic PMS2 P54278 S69Q 69 S Q 0.482 Neutral PMS2 P54278 S69R 69 S R 0.834 Pathogenic PMS2 P54278 S69T 69 S T 0.072 Neutral PMS2 P54278 S69V 69 S V 0.1 Neutral PMS2 P54278 S69W 69 S W 0.936 Pathogenic PMS2 P54278 S69Y 69 S Y 0.92 Pathogenic PMS2 P54278 K690A 690 K A 0.088 Neutral PMS2 P54278 K690C 690 K C 0.062 Neutral PMS2 P54278 K690D 690 K D 0.056 Neutral PMS2 P54278 K690E 690 K E 0.07 Neutral PMS2 P54278 K690F 690 K F 0.39 Neutral PMS2 P54278 K690G 690 K G 0.186 Neutral PMS2 P54278 K690H 690 K H 0.086 Neutral PMS2 P54278 K690I 690 K I 0.4 Neutral PMS2 P54278 K690L 690 K L 0.306 Neutral PMS2 P54278 K690M 690 K M 0.194 Neutral PMS2 P54278 K690N 690 K N 0.072 Neutral PMS2 P54278 K690P 690 K P 0.392 Neutral PMS2 P54278 K690Q 690 K Q 0.036 Neutral PMS2 P54278 K690R 690 K R 0.062 Neutral PMS2 P54278 K690S 690 K S 0.244 Neutral PMS2 P54278 K690T 690 K T 0.112 Neutral PMS2 P54278 K690V 690 K V 0.302 Neutral PMS2 P54278 K690W 690 K W 0.682 Pathogenic PMS2 P54278 K690Y 690 K Y 0.586 Pathogenic PMS2 P54278 L691A 691 L A 0.072 Neutral PMS2 P54278 L691C 691 L C 0.13 Neutral PMS2 P54278 L691D 691 L D 0.222 Neutral PMS2 P54278 L691E 691 L E 0.218 Neutral PMS2 P54278 L691F 691 L F 0.348 Neutral PMS2 P54278 L691G 691 L G 0.25 Neutral PMS2 P54278 L691H 691 L H 0.066 Neutral PMS2 P54278 L691I 691 L I 0.056 Neutral PMS2 P54278 L691K 691 L K 0.174 Neutral PMS2 P54278 L691M 691 L M 0.184 Neutral PMS2 P54278 L691N 691 L N 0.224 Neutral PMS2 P54278 L691P 691 L P 0.32 Neutral PMS2 P54278 L691Q 691 L Q 0.074 Neutral PMS2 P54278 L691R 691 L R 0.408 Neutral PMS2 P54278 L691S 691 L S 0.252 Neutral PMS2 P54278 L691T 691 L T 0.234 Neutral PMS2 P54278 L691V 691 L V 0.002 Neutral PMS2 P54278 L691W 691 L W 0.512 Pathogenic PMS2 P54278 L691Y 691 L Y 0.474 Neutral PMS2 P54278 N692A 692 N A 0.092 Neutral PMS2 P54278 N692C 692 N C 0.148 Neutral PMS2 P54278 N692D 692 N D 0.012 Neutral PMS2 P54278 N692E 692 N E 0.016 Neutral PMS2 P54278 N692F 692 N F 0.418 Neutral PMS2 P54278 N692G 692 N G 0.16 Neutral PMS2 P54278 N692H 692 N H 0.07 Neutral PMS2 P54278 N692I 692 N I 0.266 Neutral PMS2 P54278 N692K 692 N K 0.038 Neutral PMS2 P54278 N692L 692 N L 0.314 Neutral PMS2 P54278 N692M 692 N M 0.116 Neutral PMS2 P54278 N692P 692 N P 0.248 Neutral PMS2 P54278 N692Q 692 N Q 0.114 Neutral PMS2 P54278 N692R 692 N R 0.148 Neutral PMS2 P54278 N692S 692 N S 0.146 Neutral PMS2 P54278 N692T 692 N T 0.142 Neutral PMS2 P54278 N692V 692 N V 0.262 Neutral PMS2 P54278 N692W 692 N W 0.446 Neutral PMS2 P54278 N692Y 692 N Y 0.402 Neutral PMS2 P54278 E693A 693 E A 0.066 Neutral PMS2 P54278 E693C 693 E C 0.068 Neutral PMS2 P54278 E693D 693 E D 0.038 Neutral PMS2 P54278 E693F 693 E F 0.312 Neutral PMS2 P54278 E693G 693 E G 0.054 Neutral PMS2 P54278 E693H 693 E H 0.104 Neutral PMS2 P54278 E693I 693 E I 0.284 Neutral PMS2 P54278 E693K 693 E K 0.144 Neutral PMS2 P54278 E693L 693 E L 0.286 Neutral PMS2 P54278 E693M 693 E M 0.164 Neutral PMS2 P54278 E693N 693 E N 0.036 Neutral PMS2 P54278 E693P 693 E P 0.282 Neutral PMS2 P54278 E693Q 693 E Q 0.056 Neutral PMS2 P54278 E693R 693 E R 0.046 Neutral PMS2 P54278 E693S 693 E S 0.014 Neutral PMS2 P54278 E693T 693 E T 0.168 Neutral PMS2 P54278 E693V 693 E V 0.232 Neutral PMS2 P54278 E693W 693 E W 0.43 Neutral PMS2 P54278 E693Y 693 E Y 0.338 Neutral PMS2 P54278 D694A 694 D A 0.124 Neutral PMS2 P54278 D694C 694 D C 0.266 Neutral PMS2 P54278 D694E 694 D E 0.122 Neutral PMS2 P54278 D694F 694 D F 0.63 Pathogenic PMS2 P54278 D694G 694 D G 0.098 Neutral PMS2 P54278 D694H 694 D H 0.164 Neutral PMS2 P54278 D694I 694 D I 0.48 Neutral PMS2 P54278 D694K 694 D K 0.312 Neutral PMS2 P54278 D694L 694 D L 0.424 Neutral PMS2 P54278 D694M 694 D M 0.342 Neutral PMS2 P54278 D694N 694 D N 0.038 Neutral PMS2 P54278 D694P 694 D P 0.454 Neutral PMS2 P54278 D694Q 694 D Q 0.24 Neutral PMS2 P54278 D694R 694 D R 0.292 Neutral PMS2 P54278 D694S 694 D S 0.222 Neutral PMS2 P54278 D694T 694 D T 0.244 Neutral PMS2 P54278 D694V 694 D V 0.434 Neutral PMS2 P54278 D694W 694 D W 0.716 Pathogenic PMS2 P54278 D694Y 694 D Y 0.688 Pathogenic PMS2 P54278 I695A 695 I A 0.072 Neutral PMS2 P54278 I695C 695 I C 0.092 Neutral PMS2 P54278 I695D 695 I D 0.15 Neutral PMS2 P54278 I695E 695 I E 0.144 Neutral PMS2 P54278 I695F 695 I F 0.246 Neutral PMS2 P54278 I695G 695 I G 0.212 Neutral PMS2 P54278 I695H 695 I H 0.088 Neutral PMS2 P54278 I695K 695 I K 0.162 Neutral PMS2 P54278 I695L 695 I L 0 Neutral PMS2 P54278 I695M 695 I M 0.116 Neutral PMS2 P54278 I695N 695 I N 0.242 Neutral PMS2 P54278 I695P 695 I P 0.198 Neutral PMS2 P54278 I695Q 695 I Q 0.1 Neutral PMS2 P54278 I695R 695 I R 0.318 Neutral PMS2 P54278 I695S 695 I S 0.162 Neutral PMS2 P54278 I695T 695 I T 0.114 Neutral PMS2 P54278 I695V 695 I V 0.022 Neutral PMS2 P54278 I695W 695 I W 0.394 Neutral PMS2 P54278 I695Y 695 I Y 0.348 Neutral PMS2 P54278 F696A 696 F A 0.128 Neutral PMS2 P54278 F696C 696 F C 0.13 Neutral PMS2 P54278 F696D 696 F D 0.124 Neutral PMS2 P54278 F696E 696 F E 0.28 Neutral PMS2 P54278 F696G 696 F G 0.192 Neutral PMS2 P54278 F696H 696 F H 0.108 Neutral PMS2 P54278 F696I 696 F I 0.096 Neutral PMS2 P54278 F696K 696 F K 0.25 Neutral PMS2 P54278 F696L 696 F L 0.074 Neutral PMS2 P54278 F696M 696 F M 0.124 Neutral PMS2 P54278 F696N 696 F N 0.256 Neutral PMS2 P54278 F696P 696 F P 0.278 Neutral PMS2 P54278 F696Q 696 F Q 0.244 Neutral PMS2 P54278 F696R 696 F R 0.228 Neutral PMS2 P54278 F696S 696 F S 0.22 Neutral PMS2 P54278 F696T 696 F T 0.236 Neutral PMS2 P54278 F696V 696 F V 0.108 Neutral PMS2 P54278 F696W 696 F W 0.468 Neutral PMS2 P54278 F696Y 696 F Y 0.174 Neutral PMS2 P54278 I697A 697 I A 0.072 Neutral PMS2 P54278 I697C 697 I C 0.092 Neutral PMS2 P54278 I697D 697 I D 0.174 Neutral PMS2 P54278 I697E 697 I E 0.032 Neutral PMS2 P54278 I697F 697 I F 0.272 Neutral PMS2 P54278 I697G 697 I G 0.212 Neutral PMS2 P54278 I697H 697 I H 0.088 Neutral PMS2 P54278 I697K 697 I K 0.162 Neutral PMS2 P54278 I697L 697 I L 0 Neutral PMS2 P54278 I697M 697 I M 0.02 Neutral PMS2 P54278 I697N 697 I N 0.186 Neutral PMS2 P54278 I697P 697 I P 0.186 Neutral PMS2 P54278 I697Q 697 I Q 0.208 Neutral PMS2 P54278 I697R 697 I R 0.31 Neutral PMS2 P54278 I697S 697 I S 0.162 Neutral PMS2 P54278 I697T 697 I T 0.114 Neutral PMS2 P54278 I697V 697 I V 0.122 Neutral PMS2 P54278 I697W 697 I W 0.414 Neutral PMS2 P54278 I697Y 697 I Y 0.37 Neutral PMS2 P54278 V698A 698 V A 0.022 Neutral PMS2 P54278 V698C 698 V C 0.064 Neutral PMS2 P54278 V698D 698 V D 0.14 Neutral PMS2 P54278 V698E 698 V E 0.242 Neutral PMS2 P54278 V698F 698 V F 0.222 Neutral PMS2 P54278 V698G 698 V G 0.204 Neutral PMS2 P54278 V698H 698 V H 0.146 Neutral PMS2 P54278 V698I 698 V I 0.002 Neutral PMS2 P54278 V698K 698 V K 0.204 Neutral PMS2 P54278 V698L 698 V L 0.004 Neutral PMS2 P54278 V698M 698 V M 0.104 Neutral PMS2 P54278 V698N 698 V N 0.152 Neutral PMS2 P54278 V698P 698 V P 0.16 Neutral PMS2 P54278 V698Q 698 V Q 0.118 Neutral PMS2 P54278 V698R 698 V R 0.28 Neutral PMS2 P54278 V698S 698 V S 0.094 Neutral PMS2 P54278 V698T 698 V T 0.094 Neutral PMS2 P54278 V698W 698 V W 0.4 Neutral PMS2 P54278 V698Y 698 V Y 0.236 Neutral PMS2 P54278 D699A 699 D A 0.132 Neutral PMS2 P54278 D699C 699 D C 0.266 Neutral PMS2 P54278 D699E 699 D E 0.21 Neutral PMS2 P54278 D699F 699 D F 0.63 Pathogenic PMS2 P54278 D699G 699 D G 0.204 Neutral PMS2 P54278 D699H 699 D H 0.164 Neutral PMS2 P54278 D699I 699 D I 0.48 Neutral PMS2 P54278 D699K 699 D K 0.312 Neutral PMS2 P54278 D699L 699 D L 0.434 Neutral PMS2 P54278 D699M 699 D M 0.342 Neutral PMS2 P54278 D699N 699 D N 0.038 Neutral PMS2 P54278 D699P 699 D P 0.454 Neutral PMS2 P54278 D699Q 699 D Q 0.24 Neutral PMS2 P54278 D699R 699 D R 0.292 Neutral PMS2 P54278 D699S 699 D S 0.268 Neutral PMS2 P54278 D699T 699 D T 0.244 Neutral PMS2 P54278 D699V 699 D V 0.406 Neutral PMS2 P54278 D699W 699 D W 0.716 Pathogenic PMS2 P54278 D699Y 699 D Y 0.688 Pathogenic PMS2 P54278 S7A 7 S A 0.01 Neutral PMS2 P54278 S7C 7 S C 0.022 Neutral PMS2 P54278 S7D 7 S D 0.002 Neutral PMS2 P54278 S7E 7 S E 0.138 Neutral PMS2 P54278 S7F 7 S F 0.264 Neutral PMS2 P54278 S7G 7 S G 0.01 Neutral PMS2 P54278 S7H 7 S H 0.176 Neutral PMS2 P54278 S7I 7 S I 0.196 Neutral PMS2 P54278 S7K 7 S K 0.146 Neutral PMS2 P54278 S7L 7 S L 0.028 Neutral PMS2 P54278 S7M 7 S M 0.332 Neutral PMS2 P54278 S7N 7 S N 0.004 Neutral PMS2 P54278 S7P 7 S P 0.056 Neutral PMS2 P54278 S7Q 7 S Q 0.16 Neutral PMS2 P54278 S7R 7 S R 0.136 Neutral PMS2 P54278 S7T 7 S T 0.02 Neutral PMS2 P54278 S7V 7 S V 0.034 Neutral PMS2 P54278 S7W 7 S W 0.472 Neutral PMS2 P54278 S7Y 7 S Y 0.448 Neutral PMS2 P54278 D70A 70 D A 0.788 Pathogenic PMS2 P54278 D70C 70 D C 0.898 Pathogenic PMS2 P54278 D70E 70 D E 0.88 Pathogenic PMS2 P54278 D70F 70 D F 0.982 Pathogenic PMS2 P54278 D70G 70 D G 0.166 Neutral PMS2 P54278 D70H 70 D H 0.61 Pathogenic PMS2 P54278 D70I 70 D I 0.972 Pathogenic PMS2 P54278 D70K 70 D K 0.754 Pathogenic PMS2 P54278 D70L 70 D L 0.976 Pathogenic PMS2 P54278 D70M 70 D M 0.958 Pathogenic PMS2 P54278 D70N 70 D N 0.156 Neutral PMS2 P54278 D70P 70 D P 0.892 Pathogenic PMS2 P54278 D70Q 70 D Q 0.678 Pathogenic PMS2 P54278 D70R 70 D R 0.956 Pathogenic PMS2 P54278 D70S 70 D S 0.626 Pathogenic PMS2 P54278 D70T 70 D T 0.81 Pathogenic PMS2 P54278 D70V 70 D V 0.992 Pathogenic PMS2 P54278 D70W 70 D W 0.98 Pathogenic PMS2 P54278 D70Y 70 D Y 0.972 Pathogenic PMS2 P54278 Q700A 700 Q A 0.184 Neutral PMS2 P54278 Q700C 700 Q C 0.16 Neutral PMS2 P54278 Q700D 700 Q D 0.084 Neutral PMS2 P54278 Q700E 700 Q E 0.15 Neutral PMS2 P54278 Q700F 700 Q F 0.426 Neutral PMS2 P54278 Q700G 700 Q G 0.184 Neutral PMS2 P54278 Q700H 700 Q H 0.356 Neutral PMS2 P54278 Q700I 700 Q I 0.526 Pathogenic PMS2 P54278 Q700K 700 Q K 0.352 Neutral PMS2 P54278 Q700L 700 Q L 0.178 Neutral PMS2 P54278 Q700M 700 Q M 0.332 Neutral PMS2 P54278 Q700N 700 Q N 0.156 Neutral PMS2 P54278 Q700P 700 Q P 0.328 Neutral PMS2 P54278 Q700R 700 Q R 0.11 Neutral PMS2 P54278 Q700S 700 Q S 0.268 Neutral PMS2 P54278 Q700T 700 Q T 0.218 Neutral PMS2 P54278 Q700V 700 Q V 0.43 Neutral PMS2 P54278 Q700W 700 Q W 0.684 Pathogenic PMS2 P54278 Q700Y 700 Q Y 0.612 Pathogenic PMS2 P54278 H701A 701 H A 0.114 Neutral PMS2 P54278 H701C 701 H C 0.076 Neutral PMS2 P54278 H701D 701 H D 0.06 Neutral PMS2 P54278 H701E 701 H E 0.04 Neutral PMS2 P54278 H701F 701 H F 0.358 Neutral PMS2 P54278 H701G 701 H G 0.162 Neutral PMS2 P54278 H701I 701 H I 0.414 Neutral PMS2 P54278 H701K 701 H K 0.23 Neutral PMS2 P54278 H701L 701 H L 0.364 Neutral PMS2 P54278 H701M 701 H M 0.196 Neutral PMS2 P54278 H701N 701 H N 0.088 Neutral PMS2 P54278 H701P 701 H P 0.37 Neutral PMS2 P54278 H701Q 701 H Q 0.074 Neutral PMS2 P54278 H701R 701 H R 0.08 Neutral PMS2 P54278 H701S 701 H S 0.014 Neutral PMS2 P54278 H701T 701 H T 0.258 Neutral PMS2 P54278 H701V 701 H V 0.228 Neutral PMS2 P54278 H701W 701 H W 0.658 Pathogenic PMS2 P54278 H701Y 701 H Y 0.424 Neutral PMS2 P54278 A702C 702 A C 0.336 Neutral PMS2 P54278 A702D 702 A D 0.468 Neutral PMS2 P54278 A702E 702 A E 0.422 Neutral PMS2 P54278 A702F 702 A F 0.732 Pathogenic PMS2 P54278 A702G 702 A G 0.198 Neutral PMS2 P54278 A702H 702 A H 0.514 Pathogenic PMS2 P54278 A702I 702 A I 0.716 Pathogenic PMS2 P54278 A702K 702 A K 0.562 Pathogenic PMS2 P54278 A702L 702 A L 0.666 Pathogenic PMS2 P54278 A702M 702 A M 0.494 Neutral PMS2 P54278 A702N 702 A N 0.468 Neutral PMS2 P54278 A702P 702 A P 0.21 Neutral PMS2 P54278 A702Q 702 A Q 0.496 Neutral PMS2 P54278 A702R 702 A R 0.554 Pathogenic PMS2 P54278 A702S 702 A S 0.17 Neutral PMS2 P54278 A702T 702 A T 0.276 Neutral PMS2 P54278 A702V 702 A V 0.386 Neutral PMS2 P54278 A702W 702 A W 0.762 Pathogenic PMS2 P54278 A702Y 702 A Y 0.748 Pathogenic PMS2 P54278 T703A 703 T A 0.002 Neutral PMS2 P54278 T703C 703 T C 0.096 Neutral PMS2 P54278 T703D 703 T D 0.088 Neutral PMS2 P54278 T703E 703 T E 0.126 Neutral PMS2 P54278 T703F 703 T F 0.37 Neutral PMS2 P54278 T703G 703 T G 0.084 Neutral PMS2 P54278 T703H 703 T H 0.142 Neutral PMS2 P54278 T703I 703 T I 0.124 Neutral PMS2 P54278 T703K 703 T K 0.102 Neutral PMS2 P54278 T703L 703 T L 0.062 Neutral PMS2 P54278 T703M 703 T M 0.214 Neutral PMS2 P54278 T703N 703 T N 0.074 Neutral PMS2 P54278 T703P 703 T P 0.178 Neutral PMS2 P54278 T703Q 703 T Q 0.084 Neutral PMS2 P54278 T703R 703 T R 0.3 Neutral PMS2 P54278 T703S 703 T S 0.002 Neutral PMS2 P54278 T703V 703 T V 0.11 Neutral PMS2 P54278 T703W 703 T W 0.636 Pathogenic PMS2 P54278 T703Y 703 T Y 0.596 Pathogenic PMS2 P54278 D704A 704 D A 0.15 Neutral PMS2 P54278 D704C 704 D C 0.266 Neutral PMS2 P54278 D704E 704 D E 0.248 Neutral PMS2 P54278 D704F 704 D F 0.63 Pathogenic PMS2 P54278 D704G 704 D G 0.204 Neutral PMS2 P54278 D704H 704 D H 0.164 Neutral PMS2 P54278 D704I 704 D I 0.294 Neutral PMS2 P54278 D704K 704 D K 0.312 Neutral PMS2 P54278 D704L 704 D L 0.424 Neutral PMS2 P54278 D704M 704 D M 0.342 Neutral PMS2 P54278 D704N 704 D N 0.096 Neutral PMS2 P54278 D704P 704 D P 0.47 Neutral PMS2 P54278 D704Q 704 D Q 0.096 Neutral PMS2 P54278 D704R 704 D R 0.344 Neutral PMS2 P54278 D704S 704 D S 0.092 Neutral PMS2 P54278 D704T 704 D T 0.2 Neutral PMS2 P54278 D704V 704 D V 0.406 Neutral PMS2 P54278 D704W 704 D W 0.716 Pathogenic PMS2 P54278 D704Y 704 D Y 0.688 Pathogenic PMS2 P54278 E705A 705 E A 0.172 Neutral PMS2 P54278 E705C 705 E C 0.118 Neutral PMS2 P54278 E705D 705 E D 0.068 Neutral PMS2 P54278 E705F 705 E F 0.422 Neutral PMS2 P54278 E705G 705 E G 0.078 Neutral PMS2 P54278 E705H 705 E H 0.24 Neutral PMS2 P54278 E705I 705 E I 0.444 Neutral PMS2 P54278 E705K 705 E K 0.276 Neutral PMS2 P54278 E705L 705 E L 0.206 Neutral PMS2 P54278 E705M 705 E M 0.282 Neutral PMS2 P54278 E705N 705 E N 0.086 Neutral PMS2 P54278 E705P 705 E P 0.428 Neutral PMS2 P54278 E705Q 705 E Q 0.02 Neutral PMS2 P54278 E705R 705 E R 0.118 Neutral PMS2 P54278 E705S 705 E S 0.076 Neutral PMS2 P54278 E705T 705 E T 0.216 Neutral PMS2 P54278 E705V 705 E V 0.392 Neutral PMS2 P54278 E705W 705 E W 0.696 Pathogenic PMS2 P54278 E705Y 705 E Y 0.58 Pathogenic PMS2 P54278 K706A 706 K A 0.088 Neutral PMS2 P54278 K706C 706 K C 0.06 Neutral PMS2 P54278 K706D 706 K D 0.102 Neutral PMS2 P54278 K706E 706 K E 0.07 Neutral PMS2 P54278 K706F 706 K F 0.368 Neutral PMS2 P54278 K706G 706 K G 0.186 Neutral PMS2 P54278 K706H 706 K H 0.086 Neutral PMS2 P54278 K706I 706 K I 0.4 Neutral PMS2 P54278 K706L 706 K L 0.306 Neutral PMS2 P54278 K706M 706 K M 0.194 Neutral PMS2 P54278 K706N 706 K N 0.124 Neutral PMS2 P54278 K706P 706 K P 0.368 Neutral PMS2 P54278 K706Q 706 K Q 0.132 Neutral PMS2 P54278 K706R 706 K R 0.062 Neutral PMS2 P54278 K706S 706 K S 0.244 Neutral PMS2 P54278 K706T 706 K T 0.038 Neutral PMS2 P54278 K706V 706 K V 0.302 Neutral PMS2 P54278 K706W 706 K W 0.682 Pathogenic PMS2 P54278 K706Y 706 K Y 0.586 Pathogenic PMS2 P54278 Y707A 707 Y A 0.13 Neutral PMS2 P54278 Y707C 707 Y C 0.15 Neutral PMS2 P54278 Y707D 707 Y D 0.264 Neutral PMS2 P54278 Y707E 707 Y E 0.246 Neutral PMS2 P54278 Y707F 707 Y F 0.096 Neutral PMS2 P54278 Y707G 707 Y G 0.148 Neutral PMS2 P54278 Y707H 707 Y H 0.088 Neutral PMS2 P54278 Y707I 707 Y I 0.144 Neutral PMS2 P54278 Y707K 707 Y K 0.208 Neutral PMS2 P54278 Y707L 707 Y L 0.076 Neutral PMS2 P54278 Y707M 707 Y M 0.114 Neutral PMS2 P54278 Y707N 707 Y N 0.174 Neutral PMS2 P54278 Y707P 707 Y P 0.122 Neutral PMS2 P54278 Y707Q 707 Y Q 0.174 Neutral PMS2 P54278 Y707R 707 Y R 0.238 Neutral PMS2 P54278 Y707S 707 Y S 0.176 Neutral PMS2 P54278 Y707T 707 Y T 0.146 Neutral PMS2 P54278 Y707V 707 Y V 0.214 Neutral PMS2 P54278 Y707W 707 Y W 0.106 Neutral PMS2 P54278 N708A 708 N A 0.102 Neutral PMS2 P54278 N708C 708 N C 0.236 Neutral PMS2 P54278 N708D 708 N D 0.016 Neutral PMS2 P54278 N708E 708 N E 0.16 Neutral PMS2 P54278 N708F 708 N F 0.582 Pathogenic PMS2 P54278 N708G 708 N G 0.218 Neutral PMS2 P54278 N708H 708 N H 0.36 Neutral PMS2 P54278 N708I 708 N I 0.426 Neutral PMS2 P54278 N708K 708 N K 0.358 Neutral PMS2 P54278 N708L 708 N L 0.43 Neutral PMS2 P54278 N708M 708 N M 0.362 Neutral PMS2 P54278 N708P 708 N P 0.386 Neutral PMS2 P54278 N708Q 708 N Q 0.186 Neutral PMS2 P54278 N708R 708 N R 0.3 Neutral PMS2 P54278 N708S 708 N S 0.208 Neutral PMS2 P54278 N708T 708 N T 0.184 Neutral PMS2 P54278 N708V 708 N V 0.182 Neutral PMS2 P54278 N708W 708 N W 0.708 Pathogenic PMS2 P54278 N708Y 708 N Y 0.666 Pathogenic PMS2 P54278 F709A 709 F A 0.124 Neutral PMS2 P54278 F709C 709 F C 0.13 Neutral PMS2 P54278 F709D 709 F D 0.242 Neutral PMS2 P54278 F709E 709 F E 0.28 Neutral PMS2 P54278 F709G 709 F G 0.192 Neutral PMS2 P54278 F709H 709 F H 0.108 Neutral PMS2 P54278 F709I 709 F I 0.134 Neutral PMS2 P54278 F709K 709 F K 0.266 Neutral PMS2 P54278 F709L 709 F L 0.064 Neutral PMS2 P54278 F709M 709 F M 0.124 Neutral PMS2 P54278 F709N 709 F N 0.136 Neutral PMS2 P54278 F709P 709 F P 0.278 Neutral PMS2 P54278 F709Q 709 F Q 0.256 Neutral PMS2 P54278 F709R 709 F R 0.234 Neutral PMS2 P54278 F709S 709 F S 0.22 Neutral PMS2 P54278 F709T 709 F T 0.236 Neutral PMS2 P54278 F709V 709 F V 0.108 Neutral PMS2 P54278 F709W 709 F W 0.468 Neutral PMS2 P54278 F709Y 709 F Y 0.174 Neutral PMS2 P54278 N71A 71 N A 0.738 Pathogenic PMS2 P54278 N71C 71 N C 0.802 Pathogenic PMS2 P54278 N71D 71 N D 0.242 Neutral PMS2 P54278 N71E 71 N E 0.74 Pathogenic PMS2 P54278 N71F 71 N F 0.966 Pathogenic PMS2 P54278 N71G 71 N G 0.89 Pathogenic PMS2 P54278 N71H 71 N H 0.844 Pathogenic PMS2 P54278 N71I 71 N I 0.948 Pathogenic PMS2 P54278 N71K 71 N K 0.428 Neutral PMS2 P54278 N71L 71 N L 0.434 Neutral PMS2 P54278 N71M 71 N M 0.494 Neutral PMS2 P54278 N71P 71 N P 0.896 Pathogenic PMS2 P54278 N71Q 71 N Q 0.628 Pathogenic PMS2 P54278 N71R 71 N R 0.702 Pathogenic PMS2 P54278 N71S 71 N S 0.408 Neutral PMS2 P54278 N71T 71 N T 0.686 Pathogenic PMS2 P54278 N71V 71 N V 0.99 Pathogenic PMS2 P54278 N71W 71 N W 0.978 Pathogenic PMS2 P54278 N71Y 71 N Y 0.974 Pathogenic PMS2 P54278 E710A 710 E A 0.182 Neutral PMS2 P54278 E710C 710 E C 0.126 Neutral PMS2 P54278 E710D 710 E D 0.14 Neutral PMS2 P54278 E710F 710 E F 0.48 Neutral PMS2 P54278 E710G 710 E G 0.082 Neutral PMS2 P54278 E710H 710 E H 0.176 Neutral PMS2 P54278 E710I 710 E I 0.46 Neutral PMS2 P54278 E710K 710 E K 0.272 Neutral PMS2 P54278 E710L 710 E L 0.458 Neutral PMS2 P54278 E710M 710 E M 0.298 Neutral PMS2 P54278 E710N 710 E N 0.092 Neutral PMS2 P54278 E710P 710 E P 0.442 Neutral PMS2 P54278 E710Q 710 E Q 0.09 Neutral PMS2 P54278 E710R 710 E R 0.126 Neutral PMS2 P54278 E710S 710 E S 0.076 Neutral PMS2 P54278 E710T 710 E T 0.256 Neutral PMS2 P54278 E710V 710 E V 0.408 Neutral PMS2 P54278 E710W 710 E W 0.708 Pathogenic PMS2 P54278 E710Y 710 E Y 0.594 Pathogenic PMS2 P54278 M711A 711 M A 0.084 Neutral PMS2 P54278 M711C 711 M C 0.042 Neutral PMS2 P54278 M711D 711 M D 0.166 Neutral PMS2 P54278 M711E 711 M E 0.036 Neutral PMS2 P54278 M711F 711 M F 0.23 Neutral PMS2 P54278 M711G 711 M G 0.138 Neutral PMS2 P54278 M711H 711 M H 0.058 Neutral PMS2 P54278 M711I 711 M I 0.06 Neutral PMS2 P54278 M711K 711 M K 0.048 Neutral PMS2 P54278 M711L 711 M L 0.068 Neutral PMS2 P54278 M711N 711 M N 0.198 Neutral PMS2 P54278 M711P 711 M P 0.23 Neutral PMS2 P54278 M711Q 711 M Q 0.042 Neutral PMS2 P54278 M711R 711 M R 0.186 Neutral PMS2 P54278 M711S 711 M S 0.066 Neutral PMS2 P54278 M711T 711 M T 0.218 Neutral PMS2 P54278 M711V 711 M V 0.026 Neutral PMS2 P54278 M711W 711 M W 0.492 Neutral PMS2 P54278 M711Y 711 M Y 0.404 Neutral PMS2 P54278 L712A 712 L A 0.134 Neutral PMS2 P54278 L712C 712 L C 0.138 Neutral PMS2 P54278 L712D 712 L D 0.254 Neutral PMS2 P54278 L712E 712 L E 0.192 Neutral PMS2 P54278 L712F 712 L F 0.378 Neutral PMS2 P54278 L712G 712 L G 0.268 Neutral PMS2 P54278 L712H 712 L H 0.13 Neutral PMS2 P54278 L712I 712 L I 0.124 Neutral PMS2 P54278 L712K 712 L K 0.186 Neutral PMS2 P54278 L712M 712 L M 0.04 Neutral PMS2 P54278 L712N 712 L N 0.23 Neutral PMS2 P54278 L712P 712 L P 0.36 Neutral PMS2 P54278 L712Q 712 L Q 0.108 Neutral PMS2 P54278 L712R 712 L R 0.508 Pathogenic PMS2 P54278 L712S 712 L S 0.202 Neutral PMS2 P54278 L712T 712 L T 0.182 Neutral PMS2 P54278 L712V 712 L V 0.024 Neutral PMS2 P54278 L712W 712 L W 0.54 Pathogenic PMS2 P54278 L712Y 712 L Y 0.502 Pathogenic PMS2 P54278 Q713A 713 Q A 0.128 Neutral PMS2 P54278 Q713C 713 Q C 0.144 Neutral PMS2 P54278 Q713D 713 Q D 0.132 Neutral PMS2 P54278 Q713E 713 Q E 0.144 Neutral PMS2 P54278 Q713F 713 Q F 0.414 Neutral PMS2 P54278 Q713G 713 Q G 0.176 Neutral PMS2 P54278 Q713H 713 Q H 0.342 Neutral PMS2 P54278 Q713I 713 Q I 0.514 Pathogenic PMS2 P54278 Q713K 713 Q K 0.348 Neutral PMS2 P54278 Q713L 713 Q L 0.18 Neutral PMS2 P54278 Q713M 713 Q M 0.316 Neutral PMS2 P54278 Q713N 713 Q N 0.108 Neutral PMS2 P54278 Q713P 713 Q P 0.446 Neutral PMS2 P54278 Q713R 713 Q R 0.13 Neutral PMS2 P54278 Q713S 713 Q S 0.262 Neutral PMS2 P54278 Q713T 713 Q T 0.21 Neutral PMS2 P54278 Q713V 713 Q V 0.414 Neutral PMS2 P54278 Q713W 713 Q W 0.67 Pathogenic PMS2 P54278 Q713Y 713 Q Y 0.6 Pathogenic PMS2 P54278 Q714A 714 Q A 0.118 Neutral PMS2 P54278 Q714C 714 Q C 0.1 Neutral PMS2 P54278 Q714D 714 Q D 0.098 Neutral PMS2 P54278 Q714E 714 Q E 0.01 Neutral PMS2 P54278 Q714F 714 Q F 0.32 Neutral PMS2 P54278 Q714G 714 Q G 0.13 Neutral PMS2 P54278 Q714H 714 Q H 0.256 Neutral PMS2 P54278 Q714I 714 Q I 0.308 Neutral PMS2 P54278 Q714K 714 Q K 0.262 Neutral PMS2 P54278 Q714L 714 Q L 0.13 Neutral PMS2 P54278 Q714M 714 Q M 0.228 Neutral PMS2 P54278 Q714N 714 Q N 0.106 Neutral PMS2 P54278 Q714P 714 Q P 0.35 Neutral PMS2 P54278 Q714R 714 Q R 0.034 Neutral PMS2 P54278 Q714S 714 Q S 0.19 Neutral PMS2 P54278 Q714T 714 Q T 0.142 Neutral PMS2 P54278 Q714V 714 Q V 0.052 Neutral PMS2 P54278 Q714W 714 Q W 0.574 Pathogenic PMS2 P54278 Q714Y 714 Q Y 0.488 Neutral PMS2 P54278 H715A 715 H A 0.086 Neutral PMS2 P54278 H715C 715 H C 0.052 Neutral PMS2 P54278 H715D 715 H D 0.038 Neutral PMS2 P54278 H715E 715 H E 0.002 Neutral PMS2 P54278 H715F 715 H F 0.252 Neutral PMS2 P54278 H715G 715 H G 0.124 Neutral PMS2 P54278 H715I 715 H I 0.052 Neutral PMS2 P54278 H715K 715 H K 0.162 Neutral PMS2 P54278 H715L 715 H L 0.268 Neutral PMS2 P54278 H715M 715 H M 0.152 Neutral PMS2 P54278 H715N 715 H N 0.066 Neutral PMS2 P54278 H715P 715 H P 0.264 Neutral PMS2 P54278 H715Q 715 H Q 0.064 Neutral PMS2 P54278 H715R 715 H R 0.056 Neutral PMS2 P54278 H715S 715 H S 0.166 Neutral PMS2 P54278 H715T 715 H T 0.202 Neutral PMS2 P54278 H715V 715 H V 0.154 Neutral PMS2 P54278 H715W 715 H W 0.506 Pathogenic PMS2 P54278 H715Y 715 H Y 0.366 Neutral PMS2 P54278 T716A 716 T A 0.094 Neutral PMS2 P54278 T716C 716 T C 0.114 Neutral PMS2 P54278 T716D 716 T D 0.112 Neutral PMS2 P54278 T716E 716 T E 0.138 Neutral PMS2 P54278 T716F 716 T F 0.416 Neutral PMS2 P54278 T716G 716 T G 0.02 Neutral PMS2 P54278 T716H 716 T H 0.218 Neutral PMS2 P54278 T716I 716 T I 0.154 Neutral PMS2 P54278 T716K 716 T K 0.144 Neutral PMS2 P54278 T716L 716 T L 0.168 Neutral PMS2 P54278 T716M 716 T M 0.27 Neutral PMS2 P54278 T716N 716 T N 0.004 Neutral PMS2 P54278 T716P 716 T P 0.218 Neutral PMS2 P54278 T716Q 716 T Q 0.11 Neutral PMS2 P54278 T716R 716 T R 0.442 Neutral PMS2 P54278 T716S 716 T S 0.042 Neutral PMS2 P54278 T716V 716 T V 0.334 Neutral PMS2 P54278 T716W 716 T W 0.704 Pathogenic PMS2 P54278 T716Y 716 T Y 0.666 Pathogenic PMS2 P54278 V717A 717 V A 0 Neutral PMS2 P54278 V717C 717 V C 0.064 Neutral PMS2 P54278 V717D 717 V D 0.138 Neutral PMS2 P54278 V717E 717 V E 0.19 Neutral PMS2 P54278 V717F 717 V F 0.206 Neutral PMS2 P54278 V717G 717 V G 0.204 Neutral PMS2 P54278 V717H 717 V H 0.13 Neutral PMS2 P54278 V717I 717 V I 0.002 Neutral PMS2 P54278 V717K 717 V K 0.174 Neutral PMS2 P54278 V717L 717 V L 0.018 Neutral PMS2 P54278 V717M 717 V M 0.088 Neutral PMS2 P54278 V717N 717 V N 0.154 Neutral PMS2 P54278 V717P 717 V P 0.208 Neutral PMS2 P54278 V717Q 717 V Q 0.07 Neutral PMS2 P54278 V717R 717 V R 0.274 Neutral PMS2 P54278 V717S 717 V S 0.072 Neutral PMS2 P54278 V717T 717 V T 0.058 Neutral PMS2 P54278 V717W 717 V W 0.386 Neutral PMS2 P54278 V717Y 717 V Y 0.296 Neutral PMS2 P54278 L718A 718 L A 0.124 Neutral PMS2 P54278 L718C 718 L C 0.13 Neutral PMS2 P54278 L718D 718 L D 0.23 Neutral PMS2 P54278 L718E 718 L E 0.18 Neutral PMS2 P54278 L718F 718 L F 0.204 Neutral PMS2 P54278 L718G 718 L G 0.258 Neutral PMS2 P54278 L718H 718 L H 0.122 Neutral PMS2 P54278 L718I 718 L I 0.056 Neutral PMS2 P54278 L718K 718 L K 0.242 Neutral PMS2 P54278 L718M 718 L M 0.186 Neutral PMS2 P54278 L718N 718 L N 0.234 Neutral PMS2 P54278 L718P 718 L P 0.334 Neutral PMS2 P54278 L718Q 718 L Q 0.074 Neutral PMS2 P54278 L718R 718 L R 0.496 Neutral PMS2 P54278 L718S 718 L S 0.256 Neutral PMS2 P54278 L718T 718 L T 0.17 Neutral PMS2 P54278 L718V 718 L V 0.176 Neutral PMS2 P54278 L718W 718 L W 0.526 Pathogenic PMS2 P54278 L718Y 718 L Y 0.488 Neutral PMS2 P54278 Q719A 719 Q A 0.122 Neutral PMS2 P54278 Q719C 719 Q C 0.14 Neutral PMS2 P54278 Q719D 719 Q D 0.074 Neutral PMS2 P54278 Q719E 719 Q E 0.094 Neutral PMS2 P54278 Q719F 719 Q F 0.398 Neutral PMS2 P54278 Q719G 719 Q G 0.168 Neutral PMS2 P54278 Q719H 719 Q H 0.38 Neutral PMS2 P54278 Q719I 719 Q I 0.498 Neutral PMS2 P54278 Q719K 719 Q K 0.142 Neutral PMS2 P54278 Q719L 719 Q L 0.37 Neutral PMS2 P54278 Q719M 719 Q M 0.304 Neutral PMS2 P54278 Q719N 719 Q N 0.024 Neutral PMS2 P54278 Q719P 719 Q P 0.43 Neutral PMS2 P54278 Q719R 719 Q R 0.124 Neutral PMS2 P54278 Q719S 719 Q S 0.246 Neutral PMS2 P54278 Q719T 719 Q T 0.188 Neutral PMS2 P54278 Q719V 719 Q V 0.388 Neutral PMS2 P54278 Q719W 719 Q W 0.646 Pathogenic PMS2 P54278 Q719Y 719 Q Y 0.574 Pathogenic PMS2 P54278 G72A 72 G A 0.768 Pathogenic PMS2 P54278 G72C 72 G C 0.948 Pathogenic PMS2 P54278 G72D 72 G D 1 Pathogenic PMS2 P54278 G72E 72 G E 0.988 Pathogenic PMS2 P54278 G72F 72 G F 0.984 Pathogenic PMS2 P54278 G72H 72 G H 0.988 Pathogenic PMS2 P54278 G72I 72 G I 0.974 Pathogenic PMS2 P54278 G72K 72 G K 0.988 Pathogenic PMS2 P54278 G72L 72 G L 0.984 Pathogenic PMS2 P54278 G72M 72 G M 0.994 Pathogenic PMS2 P54278 G72N 72 G N 0.986 Pathogenic PMS2 P54278 G72P 72 G P 0.966 Pathogenic PMS2 P54278 G72Q 72 G Q 0.994 Pathogenic PMS2 P54278 G72R 72 G R 1 Pathogenic PMS2 P54278 G72S 72 G S 0.832 Pathogenic PMS2 P54278 G72T 72 G T 0.846 Pathogenic PMS2 P54278 G72V 72 G V 0.986 Pathogenic PMS2 P54278 G72W 72 G W 0.98 Pathogenic PMS2 P54278 G72Y 72 G Y 0.96 Pathogenic PMS2 P54278 G720A 720 G A 0.004 Neutral PMS2 P54278 G720C 720 G C 0.186 Neutral PMS2 P54278 G720D 720 G D 0.192 Neutral PMS2 P54278 G720E 720 G E 0.24 Neutral PMS2 P54278 G720F 720 G F 0.468 Neutral PMS2 P54278 G720H 720 G H 0.436 Neutral PMS2 P54278 G720I 720 G I 0.476 Neutral PMS2 P54278 G720K 720 G K 0.482 Neutral PMS2 P54278 G720L 720 G L 0.37 Neutral PMS2 P54278 G720M 720 G M 0.41 Neutral PMS2 P54278 G720N 720 G N 0.29 Neutral PMS2 P54278 G720P 720 G P 0.494 Neutral PMS2 P54278 G720Q 720 G Q 0.312 Neutral PMS2 P54278 G720R 720 G R 0.548 Pathogenic PMS2 P54278 G720S 720 G S 0.188 Neutral PMS2 P54278 G720T 720 G T 0.32 Neutral PMS2 P54278 G720V 720 G V 0.382 Neutral PMS2 P54278 G720W 720 G W 0.556 Pathogenic PMS2 P54278 G720Y 720 G Y 0.558 Pathogenic PMS2 P54278 Q721A 721 Q A 0.17 Neutral PMS2 P54278 Q721C 721 Q C 0.144 Neutral PMS2 P54278 Q721D 721 Q D 0.132 Neutral PMS2 P54278 Q721E 721 Q E 0.19 Neutral PMS2 P54278 Q721F 721 Q F 0.414 Neutral PMS2 P54278 Q721G 721 Q G 0.048 Neutral PMS2 P54278 Q721H 721 Q H 0.342 Neutral PMS2 P54278 Q721I 721 Q I 0.432 Neutral PMS2 P54278 Q721K 721 Q K 0.338 Neutral PMS2 P54278 Q721L 721 Q L 0.27 Neutral PMS2 P54278 Q721M 721 Q M 0.336 Neutral PMS2 P54278 Q721N 721 Q N 0.098 Neutral PMS2 P54278 Q721P 721 Q P 0.446 Neutral PMS2 P54278 Q721R 721 Q R 0.13 Neutral PMS2 P54278 Q721S 721 Q S 0.258 Neutral PMS2 P54278 Q721T 721 Q T 0.21 Neutral PMS2 P54278 Q721V 721 Q V 0.414 Neutral PMS2 P54278 Q721W 721 Q W 0.67 Pathogenic PMS2 P54278 Q721Y 721 Q Y 0.6 Pathogenic PMS2 P54278 R722A 722 R A 0.088 Neutral PMS2 P54278 R722C 722 R C 0.154 Neutral PMS2 P54278 R722D 722 R D 0.182 Neutral PMS2 P54278 R722E 722 R E 0.168 Neutral PMS2 P54278 R722F 722 R F 0.05 Neutral PMS2 P54278 R722G 722 R G 0.072 Neutral PMS2 P54278 R722H 722 R H 0.122 Neutral PMS2 P54278 R722I 722 R I 0.326 Neutral PMS2 P54278 R722K 722 R K 0.004 Neutral PMS2 P54278 R722L 722 R L 0.29 Neutral PMS2 P54278 R722M 722 R M 0.174 Neutral PMS2 P54278 R722N 722 R N 0.178 Neutral PMS2 P54278 R722P 722 R P 0.254 Neutral PMS2 P54278 R722Q 722 R Q 0.252 Neutral PMS2 P54278 R722S 722 R S 0.144 Neutral PMS2 P54278 R722T 722 R T 0.168 Neutral PMS2 P54278 R722V 722 R V 0.258 Neutral PMS2 P54278 R722W 722 R W 0.444 Neutral PMS2 P54278 R722Y 722 R Y 0.308 Neutral PMS2 P54278 L723A 723 L A 0.124 Neutral PMS2 P54278 L723C 723 L C 0.13 Neutral PMS2 P54278 L723D 723 L D 0.242 Neutral PMS2 P54278 L723E 723 L E 0.226 Neutral PMS2 P54278 L723F 723 L F 0.408 Neutral PMS2 P54278 L723G 723 L G 0.242 Neutral PMS2 P54278 L723H 723 L H 0.122 Neutral PMS2 P54278 L723I 723 L I 0.008 Neutral PMS2 P54278 L723K 723 L K 0.242 Neutral PMS2 P54278 L723M 723 L M 0.186 Neutral PMS2 P54278 L723N 723 L N 0.104 Neutral PMS2 P54278 L723P 723 L P 0.334 Neutral PMS2 P54278 L723Q 723 L Q 0.1 Neutral PMS2 P54278 L723R 723 L R 0.496 Neutral PMS2 P54278 L723S 723 L S 0.19 Neutral PMS2 P54278 L723T 723 L T 0.17 Neutral PMS2 P54278 L723V 723 L V 0.23 Neutral PMS2 P54278 L723W 723 L W 0.526 Pathogenic PMS2 P54278 L723Y 723 L Y 0.488 Neutral PMS2 P54278 I724A 724 I A 0.118 Neutral PMS2 P54278 I724C 724 I C 0.15 Neutral PMS2 P54278 I724D 724 I D 0.23 Neutral PMS2 P54278 I724E 724 I E 0.218 Neutral PMS2 P54278 I724F 724 I F 0.356 Neutral PMS2 P54278 I724G 724 I G 0.216 Neutral PMS2 P54278 I724H 724 I H 0.156 Neutral PMS2 P54278 I724K 724 I K 0.23 Neutral PMS2 P54278 I724L 724 I L 0.216 Neutral PMS2 P54278 I724M 724 I M 0.236 Neutral PMS2 P54278 I724N 724 I N 0.326 Neutral PMS2 P54278 I724P 724 I P 0.27 Neutral PMS2 P54278 I724Q 724 I Q 0.268 Neutral PMS2 P54278 I724R 724 I R 0.482 Neutral PMS2 P54278 I724S 724 I S 0.326 Neutral PMS2 P54278 I724T 724 I T 0.176 Neutral PMS2 P54278 I724V 724 I V 0.186 Neutral PMS2 P54278 I724W 724 I W 0.552 Pathogenic PMS2 P54278 I724Y 724 I Y 0.51 Pathogenic PMS2 P54278 A725C 725 A C 0.182 Neutral PMS2 P54278 A725D 725 A D 0.316 Neutral PMS2 P54278 A725E 725 A E 0.286 Neutral PMS2 P54278 A725F 725 A F 0.34 Neutral PMS2 P54278 A725G 725 A G 0.154 Neutral PMS2 P54278 A725H 725 A H 0.304 Neutral PMS2 P54278 A725I 725 A I 0.356 Neutral PMS2 P54278 A725K 725 A K 0.354 Neutral PMS2 P54278 A725L 725 A L 0.4 Neutral PMS2 P54278 A725M 725 A M 0.256 Neutral PMS2 P54278 A725N 725 A N 0.274 Neutral PMS2 P54278 A725P 725 A P 0.272 Neutral PMS2 P54278 A725Q 725 A Q 0.278 Neutral PMS2 P54278 A725R 725 A R 0.326 Neutral PMS2 P54278 A725S 725 A S 0.008 Neutral PMS2 P54278 A725T 725 A T 0.014 Neutral PMS2 P54278 A725V 725 A V 0.044 Neutral PMS2 P54278 A725W 725 A W 0.504 Pathogenic PMS2 P54278 A725Y 725 A Y 0.5 Pathogenic PMS2 P54278 P726A 726 P A 0.238 Neutral PMS2 P54278 P726C 726 P C 0.234 Neutral PMS2 P54278 P726D 726 P D 0.092 Neutral PMS2 P54278 P726E 726 P E 0.316 Neutral PMS2 P54278 P726F 726 P F 0.464 Neutral PMS2 P54278 P726G 726 P G 0.136 Neutral PMS2 P54278 P726H 726 P H 0.436 Neutral PMS2 P54278 P726I 726 P I 0.21 Neutral PMS2 P54278 P726K 726 P K 0.29 Neutral PMS2 P54278 P726L 726 P L 0.19 Neutral PMS2 P54278 P726M 726 P M 0.382 Neutral PMS2 P54278 P726N 726 P N 0.08 Neutral PMS2 P54278 P726Q 726 P Q 0.364 Neutral PMS2 P54278 P726R 726 P R 0.418 Neutral PMS2 P54278 P726S 726 P S 0.168 Neutral PMS2 P54278 P726T 726 P T 0.104 Neutral PMS2 P54278 P726V 726 P V 0.218 Neutral PMS2 P54278 P726W 726 P W 0.606 Pathogenic PMS2 P54278 P726Y 726 P Y 0.54 Pathogenic PMS2 P54278 Q727A 727 Q A 0.17 Neutral PMS2 P54278 Q727C 727 Q C 0.144 Neutral PMS2 P54278 Q727D 727 Q D 0.132 Neutral PMS2 P54278 Q727E 727 Q E 0.144 Neutral PMS2 P54278 Q727F 727 Q F 0.346 Neutral PMS2 P54278 Q727G 727 Q G 0.176 Neutral PMS2 P54278 Q727H 727 Q H 0.342 Neutral PMS2 P54278 Q727I 727 Q I 0.294 Neutral PMS2 P54278 Q727K 727 Q K 0.338 Neutral PMS2 P54278 Q727L 727 Q L 0.38 Neutral PMS2 P54278 Q727M 727 Q M 0.316 Neutral PMS2 P54278 Q727N 727 Q N 0.098 Neutral PMS2 P54278 Q727P 727 Q P 0.446 Neutral PMS2 P54278 Q727R 727 Q R 0.054 Neutral PMS2 P54278 Q727S 727 Q S 0.258 Neutral PMS2 P54278 Q727T 727 Q T 0.192 Neutral PMS2 P54278 Q727V 727 Q V 0.414 Neutral PMS2 P54278 Q727W 727 Q W 0.67 Pathogenic PMS2 P54278 Q727Y 727 Q Y 0.696 Pathogenic PMS2 P54278 T728A 728 T A 0.014 Neutral PMS2 P54278 T728C 728 T C 0.064 Neutral PMS2 P54278 T728D 728 T D 0.058 Neutral PMS2 P54278 T728E 728 T E 0.05 Neutral PMS2 P54278 T728F 728 T F 0.214 Neutral PMS2 P54278 T728G 728 T G 0.056 Neutral PMS2 P54278 T728H 728 T H 0.084 Neutral PMS2 P54278 T728I 728 T I 0.076 Neutral PMS2 P54278 T728K 728 T K 0.004 Neutral PMS2 P54278 T728L 728 T L 0.07 Neutral PMS2 P54278 T728M 728 T M 0.098 Neutral PMS2 P54278 T728N 728 T N 0 Neutral PMS2 P54278 T728P 728 T P 0.056 Neutral PMS2 P54278 T728Q 728 T Q 0.052 Neutral PMS2 P54278 T728R 728 T R 0.174 Neutral PMS2 P54278 T728S 728 T S 0.032 Neutral PMS2 P54278 T728V 728 T V 0.212 Neutral PMS2 P54278 T728W 728 T W 0.466 Neutral PMS2 P54278 T728Y 728 T Y 0.424 Neutral PMS2 P54278 L729A 729 L A 0.088 Neutral PMS2 P54278 L729C 729 L C 0.048 Neutral PMS2 P54278 L729D 729 L D 0.156 Neutral PMS2 P54278 L729E 729 L E 0.144 Neutral PMS2 P54278 L729F 729 L F 0.142 Neutral PMS2 P54278 L729G 729 L G 0.186 Neutral PMS2 P54278 L729H 729 L H 0.084 Neutral PMS2 P54278 L729I 729 L I 0.072 Neutral PMS2 P54278 L729K 729 L K 0.178 Neutral PMS2 P54278 L729M 729 L M 0.132 Neutral PMS2 P54278 L729N 729 L N 0.148 Neutral PMS2 P54278 L729P 729 L P 0.224 Neutral PMS2 P54278 L729Q 729 L Q 0.064 Neutral PMS2 P54278 L729R 729 L R 0.28 Neutral PMS2 P54278 L729S 729 L S 0.134 Neutral PMS2 P54278 L729T 729 L T 0.18 Neutral PMS2 P54278 L729V 729 L V 0.17 Neutral PMS2 P54278 L729W 729 L W 0.334 Neutral PMS2 P54278 L729Y 729 L Y 0.284 Neutral PMS2 P54278 C73A 73 C A 0.07 Neutral PMS2 P54278 C73D 73 C D 0.074 Neutral PMS2 P54278 C73E 73 C E 0.618 Pathogenic PMS2 P54278 C73F 73 C F 0.642 Pathogenic PMS2 P54278 C73G 73 C G 0.054 Neutral PMS2 P54278 C73H 73 C H 0.264 Neutral PMS2 P54278 C73I 73 C I 0.262 Neutral PMS2 P54278 C73K 73 C K 0.088 Neutral PMS2 P54278 C73L 73 C L 0.228 Neutral PMS2 P54278 C73M 73 C M 0.61 Pathogenic PMS2 P54278 C73N 73 C N 0.142 Neutral PMS2 P54278 C73P 73 C P 0.396 Neutral PMS2 P54278 C73Q 73 C Q 0.514 Pathogenic PMS2 P54278 C73R 73 C R 0.766 Pathogenic PMS2 P54278 C73S 73 C S 0.032 Neutral PMS2 P54278 C73T 73 C T 0.024 Neutral PMS2 P54278 C73V 73 C V 0.696 Pathogenic PMS2 P54278 C73W 73 C W 0.958 Pathogenic PMS2 P54278 C73Y 73 C Y 0.582 Pathogenic PMS2 P54278 N730A 730 N A 0.092 Neutral PMS2 P54278 N730C 730 N C 0.148 Neutral PMS2 P54278 N730D 730 N D 0.118 Neutral PMS2 P54278 N730E 730 N E 0.096 Neutral PMS2 P54278 N730F 730 N F 0.34 Neutral PMS2 P54278 N730G 730 N G 0.162 Neutral PMS2 P54278 N730H 730 N H 0.23 Neutral PMS2 P54278 N730I 730 N I 0.248 Neutral PMS2 P54278 N730K 730 N K 0.148 Neutral PMS2 P54278 N730L 730 N L 0.272 Neutral PMS2 P54278 N730M 730 N M 0.22 Neutral PMS2 P54278 N730P 730 N P 0.248 Neutral PMS2 P54278 N730Q 730 N Q 0.166 Neutral PMS2 P54278 N730R 730 N R 0.136 Neutral PMS2 P54278 N730S 730 N S 0.076 Neutral PMS2 P54278 N730T 730 N T 0.116 Neutral PMS2 P54278 N730V 730 N V 0.262 Neutral PMS2 P54278 N730W 730 N W 0.446 Neutral PMS2 P54278 N730Y 730 N Y 0.402 Neutral PMS2 P54278 L731A 731 L A 0.116 Neutral PMS2 P54278 L731C 731 L C 0.122 Neutral PMS2 P54278 L731D 731 L D 0.204 Neutral PMS2 P54278 L731E 731 L E 0.19 Neutral PMS2 P54278 L731F 731 L F 0.306 Neutral PMS2 P54278 L731G 731 L G 0.226 Neutral PMS2 P54278 L731H 731 L H 0.11 Neutral PMS2 P54278 L731I 731 L I 0.01 Neutral PMS2 P54278 L731K 731 L K 0.144 Neutral PMS2 P54278 L731M 731 L M 0.156 Neutral PMS2 P54278 L731N 731 L N 0.196 Neutral PMS2 P54278 L731P 731 L P 0.272 Neutral PMS2 P54278 L731Q 731 L Q 0.09 Neutral PMS2 P54278 L731R 731 L R 0.362 Neutral PMS2 P54278 L731S 731 L S 0.156 Neutral PMS2 P54278 L731T 731 L T 0.136 Neutral PMS2 P54278 L731V 731 L V 0.018 Neutral PMS2 P54278 L731W 731 L W 0.474 Neutral PMS2 P54278 L731Y 731 L Y 0.428 Neutral PMS2 P54278 T732A 732 T A 0.086 Neutral PMS2 P54278 T732C 732 T C 0.076 Neutral PMS2 P54278 T732D 732 T D 0.026 Neutral PMS2 P54278 T732E 732 T E 0.106 Neutral PMS2 P54278 T732F 732 T F 0.3 Neutral PMS2 P54278 T732G 732 T G 0.068 Neutral PMS2 P54278 T732H 732 T H 0.142 Neutral PMS2 P54278 T732I 732 T I 0.1 Neutral PMS2 P54278 T732K 732 T K 0.076 Neutral PMS2 P54278 T732L 732 T L 0.112 Neutral PMS2 P54278 T732M 732 T M 0.18 Neutral PMS2 P54278 T732N 732 T N 0.062 Neutral PMS2 P54278 T732P 732 T P 0.082 Neutral PMS2 P54278 T732Q 732 T Q 0.068 Neutral PMS2 P54278 T732R 732 T R 0.336 Neutral PMS2 P54278 T732S 732 T S 0.032 Neutral PMS2 P54278 T732V 732 T V 0.25 Neutral PMS2 P54278 T732W 732 T W 0.574 Pathogenic PMS2 P54278 T732Y 732 T Y 0.534 Pathogenic PMS2 P54278 A733C 733 A C 0.26 Neutral PMS2 P54278 A733D 733 A D 0.398 Neutral PMS2 P54278 A733E 733 A E 0.44 Neutral PMS2 P54278 A733F 733 A F 0.636 Pathogenic PMS2 P54278 A733G 733 A G 0.176 Neutral PMS2 P54278 A733H 733 A H 0.442 Neutral PMS2 P54278 A733I 733 A I 0.578 Pathogenic PMS2 P54278 A733K 733 A K 0.512 Pathogenic PMS2 P54278 A733L 733 A L 0.458 Neutral PMS2 P54278 A733M 733 A M 0.43 Neutral PMS2 P54278 A733N 733 A N 0.406 Neutral PMS2 P54278 A733P 733 A P 0.368 Neutral PMS2 P54278 A733Q 733 A Q 0.328 Neutral PMS2 P54278 A733R 733 A R 0.462 Neutral PMS2 P54278 A733S 733 A S 0.174 Neutral PMS2 P54278 A733T 733 A T 0.218 Neutral PMS2 P54278 A733V 733 A V 0.288 Neutral PMS2 P54278 A733W 733 A W 0.668 Pathogenic PMS2 P54278 A733Y 733 A Y 0.668 Pathogenic PMS2 P54278 V734A 734 V A 0.022 Neutral PMS2 P54278 V734C 734 V C 0.064 Neutral PMS2 P54278 V734D 734 V D 0.14 Neutral PMS2 P54278 V734E 734 V E 0.242 Neutral PMS2 P54278 V734F 734 V F 0.222 Neutral PMS2 P54278 V734G 734 V G 0.12 Neutral PMS2 P54278 V734H 734 V H 0.064 Neutral PMS2 P54278 V734I 734 V I 0.002 Neutral PMS2 P54278 V734K 734 V K 0.186 Neutral PMS2 P54278 V734L 734 V L 0.018 Neutral PMS2 P54278 V734M 734 V M 0.104 Neutral PMS2 P54278 V734N 734 V N 0.152 Neutral PMS2 P54278 V734P 734 V P 0.212 Neutral PMS2 P54278 V734Q 734 V Q 0.26 Neutral PMS2 P54278 V734R 734 V R 0.352 Neutral PMS2 P54278 V734S 734 V S 0.066 Neutral PMS2 P54278 V734T 734 V T 0.094 Neutral PMS2 P54278 V734W 734 V W 0.4 Neutral PMS2 P54278 V734Y 734 V Y 0.312 Neutral PMS2 P54278 N735A 735 N A 0.014 Neutral PMS2 P54278 N735C 735 N C 0.154 Neutral PMS2 P54278 N735D 735 N D 0.086 Neutral PMS2 P54278 N735E 735 N E 0.1 Neutral PMS2 P54278 N735F 735 N F 0.418 Neutral PMS2 P54278 N735G 735 N G 0.1 Neutral PMS2 P54278 N735H 735 N H 0.246 Neutral PMS2 P54278 N735I 735 N I 0.294 Neutral PMS2 P54278 N735K 735 N K 0.084 Neutral PMS2 P54278 N735L 735 N L 0.296 Neutral PMS2 P54278 N735M 735 N M 0.244 Neutral PMS2 P54278 N735P 735 N P 0.358 Neutral PMS2 P54278 N735Q 735 N Q 0.118 Neutral PMS2 P54278 N735R 735 N R 0.186 Neutral PMS2 P54278 N735S 735 N S 0.148 Neutral PMS2 P54278 N735T 735 N T 0.118 Neutral PMS2 P54278 N735V 735 N V 0.306 Neutral PMS2 P54278 N735W 735 N W 0.53 Pathogenic PMS2 P54278 N735Y 735 N Y 0.486 Neutral PMS2 P54278 E736A 736 E A 0.124 Neutral PMS2 P54278 E736C 736 E C 0.07 Neutral PMS2 P54278 E736D 736 E D 0.084 Neutral PMS2 P54278 E736F 736 E F 0.308 Neutral PMS2 P54278 E736G 736 E G 0.054 Neutral PMS2 P54278 E736H 736 E H 0.108 Neutral PMS2 P54278 E736I 736 E I 0.322 Neutral PMS2 P54278 E736K 736 E K 0.154 Neutral PMS2 P54278 E736L 736 E L 0.152 Neutral PMS2 P54278 E736M 736 E M 0.178 Neutral PMS2 P54278 E736N 736 E N 0.058 Neutral PMS2 P54278 E736P 736 E P 0.138 Neutral PMS2 P54278 E736Q 736 E Q 0.018 Neutral PMS2 P54278 E736R 736 E R 0.042 Neutral PMS2 P54278 E736S 736 E S 0.014 Neutral PMS2 P54278 E736T 736 E T 0.144 Neutral PMS2 P54278 E736V 736 E V 0.28 Neutral PMS2 P54278 E736W 736 E W 0.526 Pathogenic PMS2 P54278 E736Y 736 E Y 0.426 Neutral PMS2 P54278 A737C 737 A C 0.182 Neutral PMS2 P54278 A737D 737 A D 0.33 Neutral PMS2 P54278 A737E 737 A E 0.306 Neutral PMS2 P54278 A737F 737 A F 0.468 Neutral PMS2 P54278 A737G 737 A G 0.12 Neutral PMS2 P54278 A737H 737 A H 0.304 Neutral PMS2 P54278 A737I 737 A I 0.406 Neutral PMS2 P54278 A737K 737 A K 0.29 Neutral PMS2 P54278 A737L 737 A L 0.4 Neutral PMS2 P54278 A737M 737 A M 0.266 Neutral PMS2 P54278 A737N 737 A N 0.296 Neutral PMS2 P54278 A737P 737 A P 0.272 Neutral PMS2 P54278 A737Q 737 A Q 0.302 Neutral PMS2 P54278 A737R 737 A R 0.36 Neutral PMS2 P54278 A737S 737 A S 0.008 Neutral PMS2 P54278 A737T 737 A T 0.012 Neutral PMS2 P54278 A737V 737 A V 0.202 Neutral PMS2 P54278 A737W 737 A W 0.484 Neutral PMS2 P54278 A737Y 737 A Y 0.482 Neutral PMS2 P54278 V738A 738 V A 0.022 Neutral PMS2 P54278 V738C 738 V C 0.058 Neutral PMS2 P54278 V738D 738 V D 0.134 Neutral PMS2 P54278 V738E 738 V E 0.06 Neutral PMS2 P54278 V738F 738 V F 0.16 Neutral PMS2 P54278 V738G 738 V G 0.2 Neutral PMS2 P54278 V738H 738 V H 0.124 Neutral PMS2 P54278 V738I 738 V I 0.002 Neutral PMS2 P54278 V738K 738 V K 0.166 Neutral PMS2 P54278 V738L 738 V L 0.054 Neutral PMS2 P54278 V738M 738 V M 0.084 Neutral PMS2 P54278 V738N 738 V N 0.146 Neutral PMS2 P54278 V738P 738 V P 0.204 Neutral PMS2 P54278 V738Q 738 V Q 0.182 Neutral PMS2 P54278 V738R 738 V R 0.316 Neutral PMS2 P54278 V738S 738 V S 0.07 Neutral PMS2 P54278 V738T 738 V T 0.094 Neutral PMS2 P54278 V738W 738 V W 0.292 Neutral PMS2 P54278 V738Y 738 V Y 0.276 Neutral PMS2 P54278 L739A 739 L A 0.068 Neutral PMS2 P54278 L739C 739 L C 0.106 Neutral PMS2 P54278 L739D 739 L D 0.19 Neutral PMS2 P54278 L739E 739 L E 0.178 Neutral PMS2 P54278 L739F 739 L F 0.33 Neutral PMS2 P54278 L739G 739 L G 0.212 Neutral PMS2 P54278 L739H 739 L H 0.098 Neutral PMS2 P54278 L739I 739 L I 0.002 Neutral PMS2 P54278 L739K 739 L K 0.136 Neutral PMS2 P54278 L739M 739 L M 0.032 Neutral PMS2 P54278 L739N 739 L N 0.182 Neutral PMS2 P54278 L739P 739 L P 0.268 Neutral PMS2 P54278 L739Q 739 L Q 0.078 Neutral PMS2 P54278 L739R 739 L R 0.358 Neutral PMS2 P54278 L739S 739 L S 0.146 Neutral PMS2 P54278 L739T 739 L T 0.192 Neutral PMS2 P54278 L739V 739 L V 0.016 Neutral PMS2 P54278 L739W 739 L W 0.46 Neutral PMS2 P54278 L739Y 739 L Y 0.414 Neutral PMS2 P54278 G74A 74 G A 0.96 Pathogenic PMS2 P54278 G74C 74 G C 0.942 Pathogenic PMS2 P54278 G74D 74 G D 0.998 Pathogenic PMS2 P54278 G74E 74 G E 0.982 Pathogenic PMS2 P54278 G74F 74 G F 0.982 Pathogenic PMS2 P54278 G74H 74 G H 0.986 Pathogenic PMS2 P54278 G74I 74 G I 0.75 Pathogenic PMS2 P54278 G74K 74 G K 0.986 Pathogenic PMS2 P54278 G74L 74 G L 0.984 Pathogenic PMS2 P54278 G74M 74 G M 0.886 Pathogenic PMS2 P54278 G74N 74 G N 0.986 Pathogenic PMS2 P54278 G74P 74 G P 0.964 Pathogenic PMS2 P54278 G74Q 74 G Q 0.99 Pathogenic PMS2 P54278 G74R 74 G R 0.87 Pathogenic PMS2 P54278 G74S 74 G S 0.87 Pathogenic PMS2 P54278 G74T 74 G T 0.85 Pathogenic PMS2 P54278 G74V 74 G V 0.702 Pathogenic PMS2 P54278 G74W 74 G W 0.978 Pathogenic PMS2 P54278 G74Y 74 G Y 0.958 Pathogenic PMS2 P54278 I740A 740 I A 0.072 Neutral PMS2 P54278 I740C 740 I C 0.09 Neutral PMS2 P54278 I740D 740 I D 0.032 Neutral PMS2 P54278 I740E 740 I E 0.08 Neutral PMS2 P54278 I740F 740 I F 0.156 Neutral PMS2 P54278 I740G 740 I G 0.192 Neutral PMS2 P54278 I740H 740 I H 0.08 Neutral PMS2 P54278 I740K 740 I K 0.176 Neutral PMS2 P54278 I740L 740 I L 0 Neutral PMS2 P54278 I740M 740 I M 0.02 Neutral PMS2 P54278 I740N 740 I N 0.184 Neutral PMS2 P54278 I740P 740 I P 0.182 Neutral PMS2 P54278 I740Q 740 I Q 0.182 Neutral PMS2 P54278 I740R 740 I R 0.274 Neutral PMS2 P54278 I740S 740 I S 0.162 Neutral PMS2 P54278 I740T 740 I T 0.192 Neutral PMS2 P54278 I740V 740 I V 0.122 Neutral PMS2 P54278 I740W 740 I W 0.376 Neutral PMS2 P54278 I740Y 740 I Y 0.33 Neutral PMS2 P54278 E741A 741 E A 0.212 Neutral PMS2 P54278 E741C 741 E C 0.068 Neutral PMS2 P54278 E741D 741 E D 0.048 Neutral PMS2 P54278 E741F 741 E F 0.296 Neutral PMS2 P54278 E741G 741 E G 0.054 Neutral PMS2 P54278 E741H 741 E H 0.108 Neutral PMS2 P54278 E741I 741 E I 0.138 Neutral PMS2 P54278 E741K 741 E K 0.146 Neutral PMS2 P54278 E741L 741 E L 0.308 Neutral PMS2 P54278 E741M 741 E M 0.08 Neutral PMS2 P54278 E741N 741 E N 0.056 Neutral PMS2 P54278 E741P 741 E P 0.322 Neutral PMS2 P54278 E741Q 741 E Q 0.018 Neutral PMS2 P54278 E741R 741 E R 0.036 Neutral PMS2 P54278 E741S 741 E S 0.018 Neutral PMS2 P54278 E741T 741 E T 0.144 Neutral PMS2 P54278 E741V 741 E V 0.272 Neutral PMS2 P54278 E741W 741 E W 0.508 Pathogenic PMS2 P54278 E741Y 741 E Y 0.404 Neutral PMS2 P54278 N742A 742 N A 0.17 Neutral PMS2 P54278 N742C 742 N C 0.238 Neutral PMS2 P54278 N742D 742 N D 0.148 Neutral PMS2 P54278 N742E 742 N E 0.164 Neutral PMS2 P54278 N742F 742 N F 0.306 Neutral PMS2 P54278 N742G 742 N G 0.232 Neutral PMS2 P54278 N742H 742 N H 0.358 Neutral PMS2 P54278 N742I 742 N I 0.424 Neutral PMS2 P54278 N742K 742 N K 0.356 Neutral PMS2 P54278 N742L 742 N L 0.428 Neutral PMS2 P54278 N742M 742 N M 0.378 Neutral PMS2 P54278 N742P 742 N P 0.286 Neutral PMS2 P54278 N742Q 742 N Q 0.184 Neutral PMS2 P54278 N742R 742 N R 0.304 Neutral PMS2 P54278 N742S 742 N S 0.206 Neutral PMS2 P54278 N742T 742 N T 0.186 Neutral PMS2 P54278 N742V 742 N V 0.416 Neutral PMS2 P54278 N742W 742 N W 0.706 Pathogenic PMS2 P54278 N742Y 742 N Y 0.664 Pathogenic PMS2 P54278 L743A 743 L A 0.116 Neutral PMS2 P54278 L743C 743 L C 0.122 Neutral PMS2 P54278 L743D 743 L D 0.204 Neutral PMS2 P54278 L743E 743 L E 0.19 Neutral PMS2 P54278 L743F 743 L F 0.306 Neutral PMS2 P54278 L743G 743 L G 0.084 Neutral PMS2 P54278 L743H 743 L H 0.056 Neutral PMS2 P54278 L743I 743 L I 0.104 Neutral PMS2 P54278 L743K 743 L K 0.144 Neutral PMS2 P54278 L743M 743 L M 0.196 Neutral PMS2 P54278 L743N 743 L N 0.196 Neutral PMS2 P54278 L743P 743 L P 0.274 Neutral PMS2 P54278 L743Q 743 L Q 0.066 Neutral PMS2 P54278 L743R 743 L R 0.328 Neutral PMS2 P54278 L743S 743 L S 0.156 Neutral PMS2 P54278 L743T 743 L T 0.136 Neutral PMS2 P54278 L743V 743 L V 0.186 Neutral PMS2 P54278 L743W 743 L W 0.474 Neutral PMS2 P54278 L743Y 743 L Y 0.428 Neutral PMS2 P54278 E744A 744 E A 0.212 Neutral PMS2 P54278 E744C 744 E C 0.068 Neutral PMS2 P54278 E744D 744 E D 0 Neutral PMS2 P54278 E744F 744 E F 0.178 Neutral PMS2 P54278 E744G 744 E G 0.054 Neutral PMS2 P54278 E744H 744 E H 0.106 Neutral PMS2 P54278 E744I 744 E I 0.352 Neutral PMS2 P54278 E744K 744 E K 0.002 Neutral PMS2 P54278 E744L 744 E L 0.308 Neutral PMS2 P54278 E744M 744 E M 0.172 Neutral PMS2 P54278 E744N 744 E N 0.056 Neutral PMS2 P54278 E744P 744 E P 0.318 Neutral PMS2 P54278 E744Q 744 E Q 0.056 Neutral PMS2 P54278 E744R 744 E R 0.048 Neutral PMS2 P54278 E744S 744 E S 0.17 Neutral PMS2 P54278 E744T 744 E T 0.176 Neutral PMS2 P54278 E744V 744 E V 0.266 Neutral PMS2 P54278 E744W 744 E W 0.478 Neutral PMS2 P54278 E744Y 744 E Y 0.454 Neutral PMS2 P54278 I745A 745 I A 0.086 Neutral PMS2 P54278 I745C 745 I C 0.072 Neutral PMS2 P54278 I745D 745 I D 0.184 Neutral PMS2 P54278 I745E 745 I E 0.088 Neutral PMS2 P54278 I745F 745 I F 0.296 Neutral PMS2 P54278 I745G 745 I G 0.256 Neutral PMS2 P54278 I745H 745 I H 0.12 Neutral PMS2 P54278 I745K 745 I K 0.2 Neutral PMS2 P54278 I745L 745 I L 0.13 Neutral PMS2 P54278 I745M 745 I M 0.136 Neutral PMS2 P54278 I745N 745 I N 0.104 Neutral PMS2 P54278 I745P 745 I P 0.214 Neutral PMS2 P54278 I745Q 745 I Q 0.232 Neutral PMS2 P54278 I745R 745 I R 0.416 Neutral PMS2 P54278 I745S 745 I S 0.182 Neutral PMS2 P54278 I745T 745 I T 0.134 Neutral PMS2 P54278 I745V 745 I V 0.144 Neutral PMS2 P54278 I745W 745 I W 0.48 Neutral PMS2 P54278 I745Y 745 I Y 0.436 Neutral PMS2 P54278 F746A 746 F A 0.116 Neutral PMS2 P54278 F746C 746 F C 0.114 Neutral PMS2 P54278 F746D 746 F D 0.194 Neutral PMS2 P54278 F746E 746 F E 0.232 Neutral PMS2 P54278 F746G 746 F G 0.05 Neutral PMS2 P54278 F746H 746 F H 0.098 Neutral PMS2 P54278 F746I 746 F I 0.07 Neutral PMS2 P54278 F746K 746 F K 0.222 Neutral PMS2 P54278 F746L 746 F L 0.086 Neutral PMS2 P54278 F746M 746 F M 0.112 Neutral PMS2 P54278 F746N 746 F N 0.204 Neutral PMS2 P54278 F746P 746 F P 0.22 Neutral PMS2 P54278 F746Q 746 F Q 0.21 Neutral PMS2 P54278 F746R 746 F R 0.102 Neutral PMS2 P54278 F746S 746 F S 0.092 Neutral PMS2 P54278 F746T 746 F T 0.24 Neutral PMS2 P54278 F746V 746 F V 0.232 Neutral PMS2 P54278 F746W 746 F W 0.404 Neutral PMS2 P54278 F746Y 746 F Y 0.13 Neutral PMS2 P54278 R747A 747 R A 0.064 Neutral PMS2 P54278 R747C 747 R C 0.154 Neutral PMS2 P54278 R747D 747 R D 0.182 Neutral PMS2 P54278 R747E 747 R E 0.168 Neutral PMS2 P54278 R747F 747 R F 0.046 Neutral PMS2 P54278 R747G 747 R G 0.072 Neutral PMS2 P54278 R747H 747 R H 0.122 Neutral PMS2 P54278 R747I 747 R I 0.322 Neutral PMS2 P54278 R747K 747 R K 0.004 Neutral PMS2 P54278 R747L 747 R L 0.246 Neutral PMS2 P54278 R747M 747 R M 0.174 Neutral PMS2 P54278 R747N 747 R N 0.2 Neutral PMS2 P54278 R747P 747 R P 0.278 Neutral PMS2 P54278 R747Q 747 R Q 0.252 Neutral PMS2 P54278 R747S 747 R S 0.062 Neutral PMS2 P54278 R747T 747 R T 0.168 Neutral PMS2 P54278 R747V 747 R V 0.254 Neutral PMS2 P54278 R747W 747 R W 0.42 Neutral PMS2 P54278 R747Y 747 R Y 0.302 Neutral PMS2 P54278 K748A 748 K A 0.062 Neutral PMS2 P54278 K748C 748 K C 0.038 Neutral PMS2 P54278 K748D 748 K D 0.056 Neutral PMS2 P54278 K748E 748 K E 0.004 Neutral PMS2 P54278 K748F 748 K F 0.26 Neutral PMS2 P54278 K748G 748 K G 0.142 Neutral PMS2 P54278 K748H 748 K H 0.058 Neutral PMS2 P54278 K748I 748 K I 0.28 Neutral PMS2 P54278 K748L 748 K L 0.196 Neutral PMS2 P54278 K748M 748 K M 0.166 Neutral PMS2 P54278 K748N 748 K N 0.058 Neutral PMS2 P54278 K748P 748 K P 0.28 Neutral PMS2 P54278 K748Q 748 K Q 0.1 Neutral PMS2 P54278 K748R 748 K R 0.076 Neutral PMS2 P54278 K748S 748 K S 0.014 Neutral PMS2 P54278 K748T 748 K T 0.096 Neutral PMS2 P54278 K748V 748 K V 0.136 Neutral PMS2 P54278 K748W 748 K W 0.514 Pathogenic PMS2 P54278 K748Y 748 K Y 0.434 Neutral PMS2 P54278 N749A 749 N A 0.14 Neutral PMS2 P54278 N749C 749 N C 0.186 Neutral PMS2 P54278 N749D 749 N D 0.14 Neutral PMS2 P54278 N749E 749 N E 0.176 Neutral PMS2 P54278 N749F 749 N F 0.282 Neutral PMS2 P54278 N749G 749 N G 0.188 Neutral PMS2 P54278 N749H 749 N H 0.292 Neutral PMS2 P54278 N749I 749 N I 0.412 Neutral PMS2 P54278 N749K 749 N K 0.288 Neutral PMS2 P54278 N749L 749 N L 0.354 Neutral PMS2 P54278 N749M 749 N M 0.298 Neutral PMS2 P54278 N749P 749 N P 0.316 Neutral PMS2 P54278 N749Q 749 N Q 0.142 Neutral PMS2 P54278 N749R 749 N R 0.258 Neutral PMS2 P54278 N749S 749 N S 0.16 Neutral PMS2 P54278 N749T 749 N T 0.144 Neutral PMS2 P54278 N749V 749 N V 0.328 Neutral PMS2 P54278 N749W 749 N W 0.628 Pathogenic PMS2 P54278 N749Y 749 N Y 0.584 Pathogenic PMS2 P54278 V75A 75 V A 0.4 Neutral PMS2 P54278 V75C 75 V C 0.774 Pathogenic PMS2 P54278 V75D 75 V D 0.848 Pathogenic PMS2 P54278 V75E 75 V E 0.576 Pathogenic PMS2 P54278 V75F 75 V F 0.906 Pathogenic PMS2 P54278 V75G 75 V G 0.894 Pathogenic PMS2 P54278 V75H 75 V H 0.866 Pathogenic PMS2 P54278 V75I 75 V I 0.184 Neutral PMS2 P54278 V75K 75 V K 0.988 Pathogenic PMS2 P54278 V75L 75 V L 0.252 Neutral PMS2 P54278 V75M 75 V M 0.872 Pathogenic PMS2 P54278 V75N 75 V N 0.914 Pathogenic PMS2 P54278 V75P 75 V P 0.982 Pathogenic PMS2 P54278 V75Q 75 V Q 0.972 Pathogenic PMS2 P54278 V75R 75 V R 0.948 Pathogenic PMS2 P54278 V75S 75 V S 0.4 Neutral PMS2 P54278 V75T 75 V T 0.834 Pathogenic PMS2 P54278 V75W 75 V W 0.93 Pathogenic PMS2 P54278 V75Y 75 V Y 0.956 Pathogenic PMS2 P54278 G750A 750 G A 0.118 Neutral PMS2 P54278 G750C 750 G C 0.302 Neutral PMS2 P54278 G750D 750 G D 0.384 Neutral PMS2 P54278 G750E 750 G E 0.31 Neutral PMS2 P54278 G750F 750 G F 0.648 Pathogenic PMS2 P54278 G750H 750 G H 0.62 Pathogenic PMS2 P54278 G750I 750 G I 0.606 Pathogenic PMS2 P54278 G750K 750 G K 0.598 Pathogenic PMS2 P54278 G750L 750 G L 0.436 Neutral PMS2 P54278 G750M 750 G M 0.432 Neutral PMS2 P54278 G750N 750 G N 0.384 Neutral PMS2 P54278 G750P 750 G P 0.56 Pathogenic PMS2 P54278 G750Q 750 G Q 0.274 Neutral PMS2 P54278 G750R 750 G R 0.44 Neutral PMS2 P54278 G750S 750 G S 0.23 Neutral PMS2 P54278 G750T 750 G T 0.412 Neutral PMS2 P54278 G750V 750 G V 0.572 Pathogenic PMS2 P54278 G750W 750 G W 0.676 Pathogenic PMS2 P54278 G750Y 750 G Y 0.666 Pathogenic PMS2 P54278 F751A 751 F A 0.108 Neutral PMS2 P54278 F751C 751 F C 0.072 Neutral PMS2 P54278 F751D 751 F D 0.18 Neutral PMS2 P54278 F751E 751 F E 0.204 Neutral PMS2 P54278 F751G 751 F G 0.148 Neutral PMS2 P54278 F751H 751 F H 0.082 Neutral PMS2 P54278 F751I 751 F I 0.014 Neutral PMS2 P54278 F751K 751 F K 0.206 Neutral PMS2 P54278 F751L 751 F L 0.042 Neutral PMS2 P54278 F751M 751 F M 0.096 Neutral PMS2 P54278 F751N 751 F N 0.192 Neutral PMS2 P54278 F751P 751 F P 0.204 Neutral PMS2 P54278 F751Q 751 F Q 0.184 Neutral PMS2 P54278 F751R 751 F R 0.172 Neutral PMS2 P54278 F751S 751 F S 0.088 Neutral PMS2 P54278 F751T 751 F T 0.234 Neutral PMS2 P54278 F751V 751 F V 0.012 Neutral PMS2 P54278 F751W 751 F W 0.348 Neutral PMS2 P54278 F751Y 751 F Y 0.116 Neutral PMS2 P54278 D752A 752 D A 0.11 Neutral PMS2 P54278 D752C 752 D C 0.252 Neutral PMS2 P54278 D752E 752 D E 0.198 Neutral PMS2 P54278 D752F 752 D F 0.612 Pathogenic PMS2 P54278 D752G 752 D G 0.044 Neutral PMS2 P54278 D752H 752 D H 0.154 Neutral PMS2 P54278 D752I 752 D I 0.422 Neutral PMS2 P54278 D752K 752 D K 0.294 Neutral PMS2 P54278 D752L 752 D L 0.414 Neutral PMS2 P54278 D752M 752 D M 0.324 Neutral PMS2 P54278 D752N 752 D N 0.028 Neutral PMS2 P54278 D752P 752 D P 0.434 Neutral PMS2 P54278 D752Q 752 D Q 0.172 Neutral PMS2 P54278 D752R 752 D R 0.332 Neutral PMS2 P54278 D752S 752 D S 0.208 Neutral PMS2 P54278 D752T 752 D T 0.234 Neutral PMS2 P54278 D752V 752 D V 0.25 Neutral PMS2 P54278 D752W 752 D W 0.696 Pathogenic PMS2 P54278 D752Y 752 D Y 0.67 Pathogenic PMS2 P54278 F753A 753 F A 0.108 Neutral PMS2 P54278 F753C 753 F C 0.098 Neutral PMS2 P54278 F753D 753 F D 0.19 Neutral PMS2 P54278 F753E 753 F E 0.048 Neutral PMS2 P54278 F753G 753 F G 0.148 Neutral PMS2 P54278 F753H 753 F H 0.082 Neutral PMS2 P54278 F753I 753 F I 0.086 Neutral PMS2 P54278 F753K 753 F K 0.068 Neutral PMS2 P54278 F753L 753 F L 0.042 Neutral PMS2 P54278 F753M 753 F M 0.096 Neutral PMS2 P54278 F753N 753 F N 0.198 Neutral PMS2 P54278 F753P 753 F P 0.204 Neutral PMS2 P54278 F753Q 753 F Q 0.184 Neutral PMS2 P54278 F753R 753 F R 0.172 Neutral PMS2 P54278 F753S 753 F S 0.168 Neutral PMS2 P54278 F753T 753 F T 0.234 Neutral PMS2 P54278 F753V 753 F V 0.228 Neutral PMS2 P54278 F753W 753 F W 0.348 Neutral PMS2 P54278 F753Y 753 F Y 0.116 Neutral PMS2 P54278 V754A 754 V A 0.052 Neutral PMS2 P54278 V754C 754 V C 0.058 Neutral PMS2 P54278 V754D 754 V D 0.026 Neutral PMS2 P54278 V754E 754 V E 0.2 Neutral PMS2 P54278 V754F 754 V F 0.172 Neutral PMS2 P54278 V754G 754 V G 0.178 Neutral PMS2 P54278 V754H 754 V H 0.068 Neutral PMS2 P54278 V754I 754 V I 0.002 Neutral PMS2 P54278 V754K 754 V K 0.138 Neutral PMS2 P54278 V754L 754 V L 0 Neutral PMS2 P54278 V754M 754 V M 0.034 Neutral PMS2 P54278 V754N 754 V N 0.138 Neutral PMS2 P54278 V754P 754 V P 0.088 Neutral PMS2 P54278 V754Q 754 V Q 0.216 Neutral PMS2 P54278 V754R 754 V R 0.274 Neutral PMS2 P54278 V754S 754 V S 0.07 Neutral PMS2 P54278 V754T 754 V T 0.058 Neutral PMS2 P54278 V754W 754 V W 0.344 Neutral PMS2 P54278 V754Y 754 V Y 0.256 Neutral PMS2 P54278 I755A 755 I A 0.082 Neutral PMS2 P54278 I755C 755 I C 0.102 Neutral PMS2 P54278 I755D 755 I D 0.164 Neutral PMS2 P54278 I755E 755 I E 0.166 Neutral PMS2 P54278 I755F 755 I F 0.28 Neutral PMS2 P54278 I755G 755 I G 0.134 Neutral PMS2 P54278 I755H 755 I H 0.07 Neutral PMS2 P54278 I755K 755 I K 0.178 Neutral PMS2 P54278 I755L 755 I L 0.058 Neutral PMS2 P54278 I755M 755 I M 0.18 Neutral PMS2 P54278 I755N 755 I N 0.2 Neutral PMS2 P54278 I755P 755 I P 0.2 Neutral PMS2 P54278 I755Q 755 I Q 0.202 Neutral PMS2 P54278 I755R 755 I R 0.33 Neutral PMS2 P54278 I755S 755 I S 0.168 Neutral PMS2 P54278 I755T 755 I T 0.12 Neutral PMS2 P54278 I755V 755 I V 0.084 Neutral PMS2 P54278 I755W 755 I W 0.424 Neutral PMS2 P54278 I755Y 755 I Y 0.38 Neutral PMS2 P54278 D756A 756 D A 0.072 Neutral PMS2 P54278 D756C 756 D C 0.156 Neutral PMS2 P54278 D756E 756 D E 0.122 Neutral PMS2 P54278 D756F 756 D F 0.414 Neutral PMS2 P54278 D756G 756 D G 0.172 Neutral PMS2 P54278 D756H 756 D H 0.096 Neutral PMS2 P54278 D756I 756 D I 0.284 Neutral PMS2 P54278 D756K 756 D K 0.178 Neutral PMS2 P54278 D756L 756 D L 0.276 Neutral PMS2 P54278 D756M 756 D M 0.206 Neutral PMS2 P54278 D756N 756 D N 0 Neutral PMS2 P54278 D756P 756 D P 0.302 Neutral PMS2 P54278 D756Q 756 D Q 0.114 Neutral PMS2 P54278 D756R 756 D R 0.152 Neutral PMS2 P54278 D756S 756 D S 0.198 Neutral PMS2 P54278 D756T 756 D T 0.104 Neutral PMS2 P54278 D756V 756 D V 0.112 Neutral PMS2 P54278 D756W 756 D W 0.484 Neutral PMS2 P54278 D756Y 756 D Y 0.45 Neutral PMS2 P54278 E757A 757 E A 0.124 Neutral PMS2 P54278 E757C 757 E C 0.07 Neutral PMS2 P54278 E757D 757 E D 0.04 Neutral PMS2 P54278 E757F 757 E F 0.308 Neutral PMS2 P54278 E757G 757 E G 0.024 Neutral PMS2 P54278 E757H 757 E H 0.108 Neutral PMS2 P54278 E757I 757 E I 0.322 Neutral PMS2 P54278 E757K 757 E K 0.068 Neutral PMS2 P54278 E757L 757 E L 0.318 Neutral PMS2 P54278 E757M 757 E M 0.178 Neutral PMS2 P54278 E757N 757 E N 0.04 Neutral PMS2 P54278 E757P 757 E P 0.334 Neutral PMS2 P54278 E757Q 757 E Q 0.058 Neutral PMS2 P54278 E757R 757 E R 0.016 Neutral PMS2 P54278 E757S 757 E S 0.158 Neutral PMS2 P54278 E757T 757 E T 0.144 Neutral PMS2 P54278 E757V 757 E V 0.258 Neutral PMS2 P54278 E757W 757 E W 0.526 Pathogenic PMS2 P54278 E757Y 757 E Y 0.426 Neutral PMS2 P54278 N758A 758 N A 0.014 Neutral PMS2 P54278 N758C 758 N C 0.148 Neutral PMS2 P54278 N758D 758 N D 0.006 Neutral PMS2 P54278 N758E 758 N E 0.016 Neutral PMS2 P54278 N758F 758 N F 0.418 Neutral PMS2 P54278 N758G 758 N G 0.022 Neutral PMS2 P54278 N758H 758 N H 0.024 Neutral PMS2 P54278 N758I 758 N I 0.264 Neutral PMS2 P54278 N758K 758 N K 0.272 Neutral PMS2 P54278 N758L 758 N L 0.314 Neutral PMS2 P54278 N758M 758 N M 0.22 Neutral PMS2 P54278 N758P 758 N P 0.248 Neutral PMS2 P54278 N758Q 758 N Q 0.114 Neutral PMS2 P54278 N758R 758 N R 0.158 Neutral PMS2 P54278 N758S 758 N S 0 Neutral PMS2 P54278 N758T 758 N T 0.116 Neutral PMS2 P54278 N758V 758 N V 0.262 Neutral PMS2 P54278 N758W 758 N W 0.446 Neutral PMS2 P54278 N758Y 758 N Y 0.402 Neutral PMS2 P54278 A759C 759 A C 0.262 Neutral PMS2 P54278 A759D 759 A D 0.4 Neutral PMS2 P54278 A759E 759 A E 0.442 Neutral PMS2 P54278 A759F 759 A F 0.638 Pathogenic PMS2 P54278 A759G 759 A G 0.176 Neutral PMS2 P54278 A759H 759 A H 0.442 Neutral PMS2 P54278 A759I 759 A I 0.61 Pathogenic PMS2 P54278 A759K 759 A K 0.466 Neutral PMS2 P54278 A759L 759 A L 0.566 Pathogenic PMS2 P54278 A759M 759 A M 0.39 Neutral PMS2 P54278 A759N 759 A N 0.406 Neutral PMS2 P54278 A759P 759 A P 0.37 Neutral PMS2 P54278 A759Q 759 A Q 0.368 Neutral PMS2 P54278 A759R 759 A R 0.464 Neutral PMS2 P54278 A759S 759 A S 0.174 Neutral PMS2 P54278 A759T 759 A T 0.218 Neutral PMS2 P54278 A759V 759 A V 0.318 Neutral PMS2 P54278 A759W 759 A W 0.67 Pathogenic PMS2 P54278 A759Y 759 A Y 0.67 Pathogenic PMS2 P54278 E76A 76 E A 0.236 Neutral PMS2 P54278 E76C 76 E C 0.134 Neutral PMS2 P54278 E76D 76 E D 0.276 Neutral PMS2 P54278 E76F 76 E F 0.836 Pathogenic PMS2 P54278 E76G 76 E G 0.036 Neutral PMS2 P54278 E76H 76 E H 0.06 Neutral PMS2 P54278 E76I 76 E I 0.866 Pathogenic PMS2 P54278 E76K 76 E K 0.072 Neutral PMS2 P54278 E76L 76 E L 0.132 Neutral PMS2 P54278 E76M 76 E M 0.68 Pathogenic PMS2 P54278 E76N 76 E N 0.068 Neutral PMS2 P54278 E76P 76 E P 0.128 Neutral PMS2 P54278 E76Q 76 E Q 0.114 Neutral PMS2 P54278 E76R 76 E R 0.426 Neutral PMS2 P54278 E76S 76 E S 0.054 Neutral PMS2 P54278 E76T 76 E T 0.054 Neutral PMS2 P54278 E76V 76 E V 0.098 Neutral PMS2 P54278 E76W 76 E W 0.968 Pathogenic PMS2 P54278 E76Y 76 E Y 0.906 Pathogenic PMS2 P54278 P760A 760 P A 0.184 Neutral PMS2 P54278 P760C 760 P C 0.166 Neutral PMS2 P54278 P760D 760 P D 0.088 Neutral PMS2 P54278 P760E 760 P E 0.226 Neutral PMS2 P54278 P760F 760 P F 0.366 Neutral PMS2 P54278 P760G 760 P G 0.094 Neutral PMS2 P54278 P760H 760 P H 0.31 Neutral PMS2 P54278 P760I 760 P I 0.126 Neutral PMS2 P54278 P760K 760 P K 0.206 Neutral PMS2 P54278 P760L 760 P L 0.062 Neutral PMS2 P54278 P760M 760 P M 0.18 Neutral PMS2 P54278 P760N 760 P N 0.07 Neutral PMS2 P54278 P760Q 760 P Q 0.066 Neutral PMS2 P54278 P760R 760 P R 0.396 Neutral PMS2 P54278 P760S 760 P S 0.114 Neutral PMS2 P54278 P760T 760 P T 0.126 Neutral PMS2 P54278 P760V 760 P V 0.154 Neutral PMS2 P54278 P760W 760 P W 0.468 Neutral PMS2 P54278 P760Y 760 P Y 0.396 Neutral PMS2 P54278 V761A 761 V A 0 Neutral PMS2 P54278 V761C 761 V C 0.064 Neutral PMS2 P54278 V761D 761 V D 0.14 Neutral PMS2 P54278 V761E 761 V E 0.206 Neutral PMS2 P54278 V761F 761 V F 0.23 Neutral PMS2 P54278 V761G 761 V G 0.204 Neutral PMS2 P54278 V761H 761 V H 0.112 Neutral PMS2 P54278 V761I 761 V I 0.008 Neutral PMS2 P54278 V761K 761 V K 0.208 Neutral PMS2 P54278 V761L 761 V L 0.02 Neutral PMS2 P54278 V761M 761 V M 0.074 Neutral PMS2 P54278 V761N 761 V N 0.156 Neutral PMS2 P54278 V761P 761 V P 0.212 Neutral PMS2 P54278 V761Q 761 V Q 0.118 Neutral PMS2 P54278 V761R 761 V R 0.358 Neutral PMS2 P54278 V761S 761 V S 0.094 Neutral PMS2 P54278 V761T 761 V T 0.094 Neutral PMS2 P54278 V761W 761 V W 0.406 Neutral PMS2 P54278 V761Y 761 V Y 0.32 Neutral PMS2 P54278 T762A 762 T A 0.08 Neutral PMS2 P54278 T762C 762 T C 0.034 Neutral PMS2 P54278 T762D 762 T D 0.058 Neutral PMS2 P54278 T762E 762 T E 0.082 Neutral PMS2 P54278 T762F 762 T F 0.276 Neutral PMS2 P54278 T762G 762 T G 0.036 Neutral PMS2 P54278 T762H 762 T H 0.13 Neutral PMS2 P54278 T762I 762 T I 0.076 Neutral PMS2 P54278 T762K 762 T K 0.042 Neutral PMS2 P54278 T762L 762 T L 0.086 Neutral PMS2 P54278 T762M 762 T M 0.038 Neutral PMS2 P54278 T762N 762 T N 0.052 Neutral PMS2 P54278 T762P 762 T P 0.066 Neutral PMS2 P54278 T762Q 762 T Q 0.056 Neutral PMS2 P54278 T762R 762 T R 0.236 Neutral PMS2 P54278 T762S 762 T S 0.054 Neutral PMS2 P54278 T762V 762 T V 0.218 Neutral PMS2 P54278 T762W 762 T W 0.542 Pathogenic PMS2 P54278 T762Y 762 T Y 0.502 Pathogenic PMS2 P54278 E763A 763 E A 0.122 Neutral PMS2 P54278 E763C 763 E C 0.068 Neutral PMS2 P54278 E763D 763 E D 0.038 Neutral PMS2 P54278 E763F 763 E F 0.282 Neutral PMS2 P54278 E763G 763 E G 0.054 Neutral PMS2 P54278 E763H 763 E H 0.106 Neutral PMS2 P54278 E763I 763 E I 0.334 Neutral PMS2 P54278 E763K 763 E K 0.002 Neutral PMS2 P54278 E763L 763 E L 0.3 Neutral PMS2 P54278 E763M 763 E M 0.176 Neutral PMS2 P54278 E763N 763 E N 0.056 Neutral PMS2 P54278 E763P 763 E P 0.308 Neutral PMS2 P54278 E763Q 763 E Q 0 Neutral PMS2 P54278 E763R 763 E R 0.046 Neutral PMS2 P54278 E763S 763 E S 0.158 Neutral PMS2 P54278 E763T 763 E T 0.144 Neutral PMS2 P54278 E763V 763 E V 0.07 Neutral PMS2 P54278 E763W 763 E W 0.39 Neutral PMS2 P54278 E763Y 763 E Y 0.358 Neutral PMS2 P54278 R764A 764 R A 0.14 Neutral PMS2 P54278 R764C 764 R C 0.236 Neutral PMS2 P54278 R764D 764 R D 0.254 Neutral PMS2 P54278 R764E 764 R E 0.194 Neutral PMS2 P54278 R764F 764 R F 0.44 Neutral PMS2 P54278 R764G 764 R G 0.104 Neutral PMS2 P54278 R764H 764 R H 0.182 Neutral PMS2 P54278 R764I 764 R I 0.456 Neutral PMS2 P54278 R764K 764 R K 0.26 Neutral PMS2 P54278 R764L 764 R L 0.424 Neutral PMS2 P54278 R764M 764 R M 0.25 Neutral PMS2 P54278 R764N 764 R N 0.09 Neutral PMS2 P54278 R764P 764 R P 0.106 Neutral PMS2 P54278 R764Q 764 R Q 0.314 Neutral PMS2 P54278 R764S 764 R S 0.206 Neutral PMS2 P54278 R764T 764 R T 0.21 Neutral PMS2 P54278 R764V 764 R V 0.142 Neutral PMS2 P54278 R764W 764 R W 0.614 Pathogenic PMS2 P54278 R764Y 764 R Y 0.44 Neutral PMS2 P54278 A765C 765 A C 0.164 Neutral PMS2 P54278 A765D 765 A D 0.302 Neutral PMS2 P54278 A765E 765 A E 0.326 Neutral PMS2 P54278 A765F 765 A F 0.508 Pathogenic PMS2 P54278 A765G 765 A G 0.126 Neutral PMS2 P54278 A765H 765 A H 0.338 Neutral PMS2 P54278 A765I 765 A I 0.42 Neutral PMS2 P54278 A765K 765 A K 0.36 Neutral PMS2 P54278 A765L 765 A L 0.434 Neutral PMS2 P54278 A765M 765 A M 0.324 Neutral PMS2 P54278 A765N 765 A N 0.31 Neutral PMS2 P54278 A765P 765 A P 0.292 Neutral PMS2 P54278 A765Q 765 A Q 0.324 Neutral PMS2 P54278 A765R 765 A R 0.404 Neutral PMS2 P54278 A765S 765 A S 0.158 Neutral PMS2 P54278 A765T 765 A T 0.19 Neutral PMS2 P54278 A765V 765 A V 0.042 Neutral PMS2 P54278 A765W 765 A W 0.542 Pathogenic PMS2 P54278 A765Y 765 A Y 0.54 Pathogenic PMS2 P54278 K766A 766 K A 0.084 Neutral PMS2 P54278 K766C 766 K C 0.056 Neutral PMS2 P54278 K766D 766 K D 0.096 Neutral PMS2 P54278 K766E 766 K E 0.106 Neutral PMS2 P54278 K766F 766 K F 0.334 Neutral PMS2 P54278 K766G 766 K G 0.172 Neutral PMS2 P54278 K766H 766 K H 0.082 Neutral PMS2 P54278 K766I 766 K I 0.364 Neutral PMS2 P54278 K766L 766 K L 0.348 Neutral PMS2 P54278 K766M 766 K M 0.176 Neutral PMS2 P54278 K766N 766 K N 0.066 Neutral PMS2 P54278 K766P 766 K P 0.116 Neutral PMS2 P54278 K766Q 766 K Q 0.016 Neutral PMS2 P54278 K766R 766 K R 0.008 Neutral PMS2 P54278 K766S 766 K S 0.102 Neutral PMS2 P54278 K766T 766 K T 0.226 Neutral PMS2 P54278 K766V 766 K V 0.272 Neutral PMS2 P54278 K766W 766 K W 0.636 Pathogenic PMS2 P54278 K766Y 766 K Y 0.542 Pathogenic PMS2 P54278 L767A 767 L A 0.078 Neutral PMS2 P54278 L767C 767 L C 0.134 Neutral PMS2 P54278 L767D 767 L D 0.246 Neutral PMS2 P54278 L767E 767 L E 0.23 Neutral PMS2 P54278 L767F 767 L F 0.37 Neutral PMS2 P54278 L767G 767 L G 0.262 Neutral PMS2 P54278 L767H 767 L H 0.034 Neutral PMS2 P54278 L767I 767 L I 0.116 Neutral PMS2 P54278 L767K 767 L K 0.102 Neutral PMS2 P54278 L767M 767 L M 0.094 Neutral PMS2 P54278 L767N 767 L N 0.238 Neutral PMS2 P54278 L767P 767 L P 0.35 Neutral PMS2 P54278 L767Q 767 L Q 0.104 Neutral PMS2 P54278 L767R 767 L R 0.432 Neutral PMS2 P54278 L767S 767 L S 0.194 Neutral PMS2 P54278 L767T 767 L T 0.174 Neutral PMS2 P54278 L767V 767 L V 0.18 Neutral PMS2 P54278 L767W 767 L W 0.53 Pathogenic PMS2 P54278 L767Y 767 L Y 0.492 Neutral PMS2 P54278 I768A 768 I A 0.072 Neutral PMS2 P54278 I768C 768 I C 0.09 Neutral PMS2 P54278 I768D 768 I D 0.148 Neutral PMS2 P54278 I768E 768 I E 0.14 Neutral PMS2 P54278 I768F 768 I F 0.23 Neutral PMS2 P54278 I768G 768 I G 0.106 Neutral PMS2 P54278 I768H 768 I H 0.082 Neutral PMS2 P54278 I768K 768 I K 0.158 Neutral PMS2 P54278 I768L 768 I L 0.152 Neutral PMS2 P54278 I768M 768 I M 0.114 Neutral PMS2 P54278 I768N 768 I N 0.242 Neutral PMS2 P54278 I768P 768 I P 0.184 Neutral PMS2 P54278 I768Q 768 I Q 0.182 Neutral PMS2 P54278 I768R 768 I R 0.302 Neutral PMS2 P54278 I768S 768 I S 0.162 Neutral PMS2 P54278 I768T 768 I T 0.092 Neutral PMS2 P54278 I768V 768 I V 0 Neutral PMS2 P54278 I768W 768 I W 0.336 Neutral PMS2 P54278 I768Y 768 I Y 0.336 Neutral PMS2 P54278 S769A 769 S A 0.136 Neutral PMS2 P54278 S769C 769 S C 0.07 Neutral PMS2 P54278 S769D 769 S D 0.112 Neutral PMS2 P54278 S769E 769 S E 0.326 Neutral PMS2 P54278 S769F 769 S F 0.508 Pathogenic PMS2 P54278 S769G 769 S G 0.112 Neutral PMS2 P54278 S769H 769 S H 0.434 Neutral PMS2 P54278 S769I 769 S I 0.25 Neutral PMS2 P54278 S769K 769 S K 0.362 Neutral PMS2 P54278 S769L 769 S L 0.164 Neutral PMS2 P54278 S769M 769 S M 0.616 Pathogenic PMS2 P54278 S769N 769 S N 0.062 Neutral PMS2 P54278 S769P 769 S P 0.21 Neutral PMS2 P54278 S769Q 769 S Q 0.32 Neutral PMS2 P54278 S769R 769 S R 0.272 Neutral PMS2 P54278 S769T 769 S T 0.06 Neutral PMS2 P54278 S769V 769 S V 0.44 Neutral PMS2 P54278 S769W 769 S W 0.732 Pathogenic PMS2 P54278 S769Y 769 S Y 0.692 Pathogenic PMS2 P54278 E77A 77 E A 0.45 Neutral PMS2 P54278 E77C 77 E C 0.492 Neutral PMS2 P54278 E77D 77 E D 0.54 Pathogenic PMS2 P54278 E77F 77 E F 0.89 Pathogenic PMS2 P54278 E77G 77 E G 0.212 Neutral PMS2 P54278 E77H 77 E H 0.608 Pathogenic PMS2 P54278 E77I 77 E I 0.842 Pathogenic PMS2 P54278 E77K 77 E K 0.038 Neutral PMS2 P54278 E77L 77 E L 0.908 Pathogenic PMS2 P54278 E77M 77 E M 0.714 Pathogenic PMS2 P54278 E77N 77 E N 0.13 Neutral PMS2 P54278 E77P 77 E P 0.124 Neutral PMS2 P54278 E77Q 77 E Q 0.018 Neutral PMS2 P54278 E77R 77 E R 0.12 Neutral PMS2 P54278 E77S 77 E S 0.046 Neutral PMS2 P54278 E77T 77 E T 0.044 Neutral PMS2 P54278 E77V 77 E V 0.098 Neutral PMS2 P54278 E77W 77 E W 0.964 Pathogenic PMS2 P54278 E77Y 77 E Y 0.924 Pathogenic PMS2 P54278 L770A 770 L A 0.128 Neutral PMS2 P54278 L770C 770 L C 0.074 Neutral PMS2 P54278 L770D 770 L D 0.246 Neutral PMS2 P54278 L770E 770 L E 0.23 Neutral PMS2 P54278 L770F 770 L F 0.37 Neutral PMS2 P54278 L770G 770 L G 0.262 Neutral PMS2 P54278 L770H 770 L H 0.126 Neutral PMS2 P54278 L770I 770 L I 0.042 Neutral PMS2 P54278 L770K 770 L K 0.18 Neutral PMS2 P54278 L770M 770 L M 0.19 Neutral PMS2 P54278 L770N 770 L N 0.238 Neutral PMS2 P54278 L770P 770 L P 0.304 Neutral PMS2 P54278 L770Q 770 L Q 0.104 Neutral PMS2 P54278 L770R 770 L R 0.5 Pathogenic PMS2 P54278 L770S 770 L S 0.26 Neutral PMS2 P54278 L770T 770 L T 0.242 Neutral PMS2 P54278 L770V 770 L V 0.096 Neutral PMS2 P54278 L770W 770 L W 0.53 Pathogenic PMS2 P54278 L770Y 770 L Y 0.492 Neutral PMS2 P54278 P771A 771 P A 0.25 Neutral PMS2 P54278 P771C 771 P C 0.234 Neutral PMS2 P54278 P771D 771 P D 0.088 Neutral PMS2 P54278 P771E 771 P E 0.314 Neutral PMS2 P54278 P771F 771 P F 0.374 Neutral PMS2 P54278 P771G 771 P G 0.13 Neutral PMS2 P54278 P771H 771 P H 0.476 Neutral PMS2 P54278 P771I 771 P I 0.21 Neutral PMS2 P54278 P771K 771 P K 0.356 Neutral PMS2 P54278 P771L 771 P L 0.176 Neutral PMS2 P54278 P771M 771 P M 0.38 Neutral PMS2 P54278 P771N 771 P N 0.102 Neutral PMS2 P54278 P771Q 771 P Q 0.3 Neutral PMS2 P54278 P771R 771 P R 0.528 Pathogenic PMS2 P54278 P771S 771 P S 0.164 Neutral PMS2 P54278 P771T 771 P T 0.102 Neutral PMS2 P54278 P771V 771 P V 0.216 Neutral PMS2 P54278 P771W 771 P W 0.608 Pathogenic PMS2 P54278 P771Y 771 P Y 0.54 Pathogenic PMS2 P54278 T772A 772 T A 0.12 Neutral PMS2 P54278 T772C 772 T C 0.11 Neutral PMS2 P54278 T772D 772 T D 0.066 Neutral PMS2 P54278 T772E 772 T E 0.16 Neutral PMS2 P54278 T772F 772 T F 0.37 Neutral PMS2 P54278 T772G 772 T G 0.052 Neutral PMS2 P54278 T772H 772 T H 0.164 Neutral PMS2 P54278 T772I 772 T I 0.144 Neutral PMS2 P54278 T772K 772 T K 0.1 Neutral PMS2 P54278 T772L 772 T L 0.156 Neutral PMS2 P54278 T772M 772 T M 0.068 Neutral PMS2 P54278 T772N 772 T N 0.084 Neutral PMS2 P54278 T772P 772 T P 0.206 Neutral PMS2 P54278 T772Q 772 T Q 0.052 Neutral PMS2 P54278 T772R 772 T R 0.424 Neutral PMS2 P54278 T772S 772 T S 0.04 Neutral PMS2 P54278 T772V 772 T V 0.318 Neutral PMS2 P54278 T772W 772 T W 0.684 Pathogenic PMS2 P54278 T772Y 772 T Y 0.646 Pathogenic PMS2 P54278 S773A 773 S A 0.138 Neutral PMS2 P54278 S773C 773 S C 0.056 Neutral PMS2 P54278 S773D 773 S D 0.114 Neutral PMS2 P54278 S773E 773 S E 0.278 Neutral PMS2 P54278 S773F 773 S F 0.51 Pathogenic PMS2 P54278 S773G 773 S G 0.07 Neutral PMS2 P54278 S773H 773 S H 0.436 Neutral PMS2 P54278 S773I 773 S I 0.162 Neutral PMS2 P54278 S773K 773 S K 0.364 Neutral PMS2 P54278 S773L 773 S L 0.198 Neutral PMS2 P54278 S773M 773 S M 0.618 Pathogenic PMS2 P54278 S773N 773 S N 0.102 Neutral PMS2 P54278 S773P 773 S P 0.138 Neutral PMS2 P54278 S773Q 773 S Q 0.322 Neutral PMS2 P54278 S773R 773 S R 0.274 Neutral PMS2 P54278 S773T 773 S T 0.186 Neutral PMS2 P54278 S773V 773 S V 0.442 Neutral PMS2 P54278 S773W 773 S W 0.732 Pathogenic PMS2 P54278 S773Y 773 S Y 0.694 Pathogenic PMS2 P54278 K774A 774 K A 0.088 Neutral PMS2 P54278 K774C 774 K C 0.06 Neutral PMS2 P54278 K774D 774 K D 0.1 Neutral PMS2 P54278 K774E 774 K E 0.11 Neutral PMS2 P54278 K774F 774 K F 0.356 Neutral PMS2 P54278 K774G 774 K G 0.182 Neutral PMS2 P54278 K774H 774 K H 0.02 Neutral PMS2 P54278 K774I 774 K I 0.386 Neutral PMS2 P54278 K774L 774 K L 0.37 Neutral PMS2 P54278 K774M 774 K M 0.19 Neutral PMS2 P54278 K774N 774 K N 0.068 Neutral PMS2 P54278 K774P 774 K P 0.378 Neutral PMS2 P54278 K774Q 774 K Q 0.066 Neutral PMS2 P54278 K774R 774 K R 0.014 Neutral PMS2 P54278 K774S 774 K S 0.236 Neutral PMS2 P54278 K774T 774 K T 0.142 Neutral PMS2 P54278 K774V 774 K V 0.296 Neutral PMS2 P54278 K774W 774 K W 0.464 Neutral PMS2 P54278 K774Y 774 K Y 0.574 Pathogenic PMS2 P54278 N775A 775 N A 0.158 Neutral PMS2 P54278 N775C 775 N C 0.23 Neutral PMS2 P54278 N775D 775 N D 0.038 Neutral PMS2 P54278 N775E 775 N E 0.16 Neutral PMS2 P54278 N775F 775 N F 0.556 Pathogenic PMS2 P54278 N775G 775 N G 0.222 Neutral PMS2 P54278 N775H 775 N H 0.348 Neutral PMS2 P54278 N775I 775 N I 0.41 Neutral PMS2 P54278 N775K 775 N K 0.346 Neutral PMS2 P54278 N775L 775 N L 0.236 Neutral PMS2 P54278 N775M 775 N M 0.346 Neutral PMS2 P54278 N775P 775 N P 0.472 Neutral PMS2 P54278 N775Q 775 N Q 0.23 Neutral PMS2 P54278 N775R 775 N R 0.286 Neutral PMS2 P54278 N775S 775 N S 0.004 Neutral 1 PMS2 P54278 N775T 775 N T 0.18 Neutral PMS2 P54278 N775V 775 N V 0.424 Neutral PMS2 P54278 N775W 775 N W 0.682 Pathogenic PMS2 P54278 N775Y 775 N Y 0.64 Pathogenic PMS2 P54278 W776A 776 W A 0.134 Neutral PMS2 P54278 W776C 776 W C 0.14 Neutral PMS2 P54278 W776D 776 W D 0.198 Neutral PMS2 P54278 W776E 776 W E 0.23 Neutral PMS2 P54278 W776F 776 W F 0.044 Neutral PMS2 P54278 W776G 776 W G 0.146 Neutral PMS2 P54278 W776H 776 W H 0.132 Neutral PMS2 P54278 W776I 776 W I 0.122 Neutral PMS2 P54278 W776K 776 W K 0.25 Neutral PMS2 P54278 W776L 776 W L 0.122 Neutral PMS2 P54278 W776M 776 W M 0.128 Neutral PMS2 P54278 W776N 776 W N 0.146 Neutral PMS2 P54278 W776P 776 W P 0.156 Neutral PMS2 P54278 W776Q 776 W Q 0.148 Neutral PMS2 P54278 W776R 776 W R 0.236 Neutral PMS2 P54278 W776S 776 W S 0.15 Neutral PMS2 P54278 W776T 776 W T 0.138 Neutral PMS2 P54278 W776V 776 W V 0.212 Neutral PMS2 P54278 W776Y 776 W Y 0.208 Neutral PMS2 P54278 T777A 777 T A 0.12 Neutral PMS2 P54278 T777C 777 T C 0.11 Neutral PMS2 P54278 T777D 777 T D 0.108 Neutral PMS2 P54278 T777E 777 T E 0.136 Neutral PMS2 P54278 T777F 777 T F 0.412 Neutral PMS2 P54278 T777G 777 T G 0.092 Neutral PMS2 P54278 T777H 777 T H 0.212 Neutral PMS2 P54278 T777I 777 T I 0.15 Neutral PMS2 P54278 T777K 777 T K 0.14 Neutral PMS2 P54278 T777L 777 T L 0.082 Neutral PMS2 P54278 T777M 777 T M 0.196 Neutral PMS2 P54278 T777N 777 T N 0.02 Neutral PMS2 P54278 T777P 777 T P 0.108 Neutral PMS2 P54278 T777Q 777 T Q 0.05 Neutral PMS2 P54278 T777R 777 T R 0.438 Neutral PMS2 P54278 T777S 777 T S 0.088 Neutral PMS2 P54278 T777V 777 T V 0.33 Neutral PMS2 P54278 T777W 777 T W 0.706 Pathogenic PMS2 P54278 T777Y 777 T Y 0.668 Pathogenic PMS2 P54278 F778A 778 F A 0.12 Neutral PMS2 P54278 F778C 778 F C 0.122 Neutral PMS2 P54278 F778D 778 F D 0.232 Neutral PMS2 P54278 F778E 778 F E 0.08 Neutral PMS2 P54278 F778G 778 F G 0.186 Neutral PMS2 P54278 F778H 778 F H 0.018 Neutral PMS2 P54278 F778I 778 F I 0.122 Neutral PMS2 P54278 F778K 778 F K 0.258 Neutral PMS2 P54278 F778L 778 F L 0.076 Neutral PMS2 P54278 F778M 778 F M 0.118 Neutral PMS2 P54278 F778N 778 F N 0.246 Neutral PMS2 P54278 F778P 778 F P 0.27 Neutral PMS2 P54278 F778Q 778 F Q 0.248 Neutral PMS2 P54278 F778R 778 F R 0.226 Neutral PMS2 P54278 F778S 778 F S 0.216 Neutral PMS2 P54278 F778T 778 F T 0.226 Neutral PMS2 P54278 F778V 778 F V 0.226 Neutral PMS2 P54278 F778W 778 F W 0.46 Neutral PMS2 P54278 F778Y 778 F Y 0.168 Neutral PMS2 P54278 G779A 779 G A 0.098 Neutral PMS2 P54278 G779C 779 G C 0.37 Neutral PMS2 P54278 G779D 779 G D 0.328 Neutral PMS2 P54278 G779E 779 G E 0.574 Pathogenic PMS2 P54278 G779F 779 G F 0.772 Pathogenic PMS2 P54278 G779H 779 G H 0.644 Pathogenic PMS2 P54278 G779I 779 G I 0.706 Pathogenic PMS2 P54278 G779K 779 G K 0.698 Pathogenic PMS2 P54278 G779L 779 G L 0.526 Pathogenic PMS2 P54278 G779M 779 G M 0.706 Pathogenic PMS2 P54278 G779N 779 G N 0.428 Neutral PMS2 P54278 G779P 779 G P 0.646 Pathogenic PMS2 P54278 G779Q 779 G Q 0.46 Neutral PMS2 P54278 G779R 779 G R 0.764 Pathogenic PMS2 P54278 G779S 779 G S 0.296 Neutral PMS2 P54278 G779T 779 G T 0.478 Neutral PMS2 P54278 G779V 779 G V 0.668 Pathogenic PMS2 P54278 G779W 779 G W 0.77 Pathogenic PMS2 P54278 G779Y 779 G Y 0.754 Pathogenic PMS2 P54278 E78A 78 E A 0.234 Neutral PMS2 P54278 E78C 78 E C 0.42 Neutral PMS2 P54278 E78D 78 E D 0.028 Neutral PMS2 P54278 E78F 78 E F 0.8 Pathogenic PMS2 P54278 E78G 78 E G 0.02 Neutral PMS2 P54278 E78H 78 E H 0.072 Neutral PMS2 P54278 E78I 78 E I 0.87 Pathogenic PMS2 P54278 E78K 78 E K 0.064 Neutral PMS2 P54278 E78L 78 E L 0.278 Neutral PMS2 P54278 E78M 78 E M 0.388 Neutral PMS2 P54278 E78N 78 E N 0.026 Neutral PMS2 P54278 E78P 78 E P 0.806 Pathogenic PMS2 P54278 E78Q 78 E Q 0.024 Neutral PMS2 P54278 E78R 78 E R 0.122 Neutral PMS2 P54278 E78S 78 E S 0.036 Neutral PMS2 P54278 E78T 78 E T 0.05 Neutral PMS2 P54278 E78V 78 E V 0.812 Pathogenic PMS2 P54278 E78W 78 E W 0.94 Pathogenic PMS2 P54278 E78Y 78 E Y 0.886 Pathogenic PMS2 P54278 P780A 780 P A 0.228 Neutral PMS2 P54278 P780C 780 P C 0.226 Neutral PMS2 P54278 P780D 780 P D 0.128 Neutral PMS2 P54278 P780E 780 P E 0.35 Neutral PMS2 P54278 P780F 780 P F 0.488 Neutral PMS2 P54278 P780G 780 P G 0.13 Neutral PMS2 P54278 P780H 780 P H 0.458 Neutral PMS2 P54278 P780I 780 P I 0.13 Neutral PMS2 P54278 P780K 780 P K 0.342 Neutral PMS2 P54278 P780L 780 P L 0.05 Neutral PMS2 P54278 P780M 780 P M 0.366 Neutral PMS2 P54278 P780N 780 P N 0.102 Neutral PMS2 P54278 P780Q 780 P Q 0.286 Neutral PMS2 P54278 P780R 780 P R 0.298 Neutral PMS2 P54278 P780S 780 P S 0.16 Neutral PMS2 P54278 P780T 780 P T 0.186 Neutral PMS2 P54278 P780V 780 P V 0.25 Neutral PMS2 P54278 P780W 780 P W 0.586 Pathogenic PMS2 P54278 P780Y 780 P Y 0.52 Pathogenic PMS2 P54278 Q781A 781 Q A 0.036 Neutral PMS2 P54278 Q781C 781 Q C 0.084 Neutral PMS2 P54278 Q781D 781 Q D 0.088 Neutral PMS2 P54278 Q781E 781 Q E 0.068 Neutral PMS2 P54278 Q781F 781 Q F 0.284 Neutral PMS2 P54278 Q781G 781 Q G 0.118 Neutral PMS2 P54278 Q781H 781 Q H 0.268 Neutral PMS2 P54278 Q781I 781 Q I 0.292 Neutral PMS2 P54278 Q781K 781 Q K 0.22 Neutral PMS2 P54278 Q781L 781 Q L 0.35 Neutral PMS2 P54278 Q781M 781 Q M 0.196 Neutral PMS2 P54278 Q781N 781 Q N 0.082 Neutral PMS2 P54278 Q781P 781 Q P 0.276 Neutral PMS2 P54278 Q781R 781 Q R 0.046 Neutral PMS2 P54278 Q781S 781 Q S 0.186 Neutral PMS2 P54278 Q781T 781 Q T 0.132 Neutral PMS2 P54278 Q781V 781 Q V 0.288 Neutral PMS2 P54278 Q781W 781 Q W 0.476 Neutral PMS2 P54278 Q781Y 781 Q Y 0.504 Pathogenic PMS2 P54278 D782A 782 D A 0.136 Neutral PMS2 P54278 D782C 782 D C 0.252 Neutral PMS2 P54278 D782E 782 D E 0.198 Neutral PMS2 P54278 D782F 782 D F 0.612 Pathogenic PMS2 P54278 D782G 782 D G 0.196 Neutral PMS2 P54278 D782H 782 D H 0.154 Neutral PMS2 P54278 D782I 782 D I 0.422 Neutral PMS2 P54278 D782K 782 D K 0.294 Neutral PMS2 P54278 D782L 782 D L 0.17 Neutral PMS2 P54278 D782M 782 D M 0.324 Neutral PMS2 P54278 D782N 782 D N 0.028 Neutral PMS2 P54278 D782P 782 D P 0.434 Neutral PMS2 P54278 D782Q 782 D Q 0.226 Neutral PMS2 P54278 D782R 782 D R 0.28 Neutral PMS2 P54278 D782S 782 D S 0.208 Neutral PMS2 P54278 D782T 782 D T 0.128 Neutral PMS2 P54278 D782V 782 D V 0.414 Neutral PMS2 P54278 D782W 782 D W 0.696 Pathogenic PMS2 P54278 D782Y 782 D Y 0.67 Pathogenic PMS2 P54278 V783A 783 V A 0.052 Neutral PMS2 P54278 V783C 783 V C 0.108 Neutral PMS2 P54278 V783D 783 V D 0.2 Neutral PMS2 P54278 V783E 783 V E 0.282 Neutral PMS2 P54278 V783F 783 V F 0.364 Neutral PMS2 P54278 V783G 783 V G 0.276 Neutral PMS2 P54278 V783H 783 V H 0.232 Neutral PMS2 P54278 V783I 783 V I 0.018 Neutral PMS2 P54278 V783K 783 V K 0.296 Neutral PMS2 P54278 V783L 783 V L 0.04 Neutral PMS2 P54278 V783M 783 V M 0.072 Neutral PMS2 P54278 V783N 783 V N 0.218 Neutral PMS2 P54278 V783P 783 V P 0.332 Neutral PMS2 P54278 V783Q 783 V Q 0.352 Neutral PMS2 P54278 V783R 783 V R 0.488 Neutral PMS2 P54278 V783S 783 V S 0.146 Neutral PMS2 P54278 V783T 783 V T 0.13 Neutral PMS2 P54278 V783W 783 V W 0.536 Pathogenic PMS2 P54278 V783Y 783 V Y 0.456 Neutral PMS2 P54278 D784A 784 D A 0.082 Neutral PMS2 P54278 D784C 784 D C 0.156 Neutral PMS2 P54278 D784E 784 D E 0.014 Neutral PMS2 P54278 D784F 784 D F 0.44 Neutral PMS2 P54278 D784G 784 D G 0.142 Neutral PMS2 P54278 D784H 784 D H 0.098 Neutral PMS2 P54278 D784I 784 D I 0.288 Neutral PMS2 P54278 D784K 784 D K 0.184 Neutral PMS2 P54278 D784L 784 D L 0.284 Neutral PMS2 P54278 D784M 784 D M 0.21 Neutral PMS2 P54278 D784N 784 D N 0.058 Neutral PMS2 P54278 D784P 784 D P 0.306 Neutral PMS2 P54278 D784Q 784 D Q 0.116 Neutral PMS2 P54278 D784R 784 D R 0.172 Neutral PMS2 P54278 D784S 784 D S 0.15 Neutral PMS2 P54278 D784T 784 D T 0.162 Neutral PMS2 P54278 D784V 784 D V 0.288 Neutral PMS2 P54278 D784W 784 D W 0.514 Pathogenic PMS2 P54278 D784Y 784 D Y 0.48 Neutral PMS2 P54278 E785A 785 E A 0.184 Neutral PMS2 P54278 E785C 785 E C 0.13 Neutral PMS2 P54278 E785D 785 E D 0.08 Neutral PMS2 P54278 E785F 785 E F 0.44 Neutral PMS2 P54278 E785G 785 E G 0.086 Neutral PMS2 P54278 E785H 785 E H 0.13 Neutral PMS2 P54278 E785I 785 E I 0.464 Neutral PMS2 P54278 E785K 785 E K 0.294 Neutral PMS2 P54278 E785L 785 E L 0.462 Neutral PMS2 P54278 E785M 785 E M 0.302 Neutral PMS2 P54278 E785N 785 E N 0.094 Neutral PMS2 P54278 E785P 785 E P 0.474 Neutral PMS2 P54278 E785Q 785 E Q 0.092 Neutral PMS2 P54278 E785R 785 E R 0.102 Neutral PMS2 P54278 E785S 785 E S 0.234 Neutral PMS2 P54278 E785T 785 E T 0.228 Neutral PMS2 P54278 E785V 785 E V 0.412 Neutral PMS2 P54278 E785W 785 E W 0.712 Pathogenic PMS2 P54278 E785Y 785 E Y 0.598 Pathogenic PMS2 P54278 L786A 786 L A 0.132 Neutral PMS2 P54278 L786C 786 L C 0.136 Neutral PMS2 P54278 L786D 786 L D 0.25 Neutral PMS2 P54278 L786E 786 L E 0.232 Neutral PMS2 P54278 L786F 786 L F 0.374 Neutral PMS2 P54278 L786G 786 L G 0.25 Neutral PMS2 P54278 L786H 786 L H 0.128 Neutral PMS2 P54278 L786I 786 L I 0.122 Neutral PMS2 P54278 L786K 786 L K 0.182 Neutral PMS2 P54278 L786M 786 L M 0.094 Neutral PMS2 P54278 L786N 786 L N 0.242 Neutral PMS2 P54278 L786P 786 L P 0.344 Neutral PMS2 P54278 L786Q 786 L Q 0.104 Neutral PMS2 P54278 L786R 786 L R 0.504 Pathogenic PMS2 P54278 L786S 786 L S 0.198 Neutral PMS2 P54278 L786T 786 L T 0.248 Neutral PMS2 P54278 L786V 786 L V 0.184 Neutral PMS2 P54278 L786W 786 L W 0.536 Pathogenic PMS2 P54278 L786Y 786 L Y 0.498 Neutral PMS2 P54278 I787A 787 I A 0.094 Neutral PMS2 P54278 I787C 787 I C 0.138 Neutral PMS2 P54278 I787D 787 I D 0.212 Neutral PMS2 P54278 I787E 787 I E 0.202 Neutral PMS2 P54278 I787F 787 I F 0.332 Neutral PMS2 P54278 I787G 787 I G 0.27 Neutral PMS2 P54278 I787H 787 I H 0.142 Neutral PMS2 P54278 I787K 787 I K 0.218 Neutral PMS2 P54278 I787L 787 I L 0.066 Neutral PMS2 P54278 I787M 787 I M 0.222 Neutral PMS2 P54278 I787N 787 I N 0.25 Neutral PMS2 P54278 I787P 787 I P 0.246 Neutral PMS2 P54278 I787Q 787 I Q 0.268 Neutral PMS2 P54278 I787R 787 I R 0.452 Neutral PMS2 P54278 I787S 787 I S 0.308 Neutral PMS2 P54278 I787T 787 I T 0.24 Neutral PMS2 P54278 I787V 787 I V 0.092 Neutral PMS2 P54278 I787W 787 I W 0.518 Pathogenic PMS2 P54278 I787Y 787 I Y 0.476 Neutral PMS2 P54278 F788A 788 F A 0.122 Neutral PMS2 P54278 F788C 788 F C 0.122 Neutral PMS2 P54278 F788D 788 F D 0.234 Neutral PMS2 P54278 F788E 788 F E 0.254 Neutral PMS2 P54278 F788G 788 F G 0.186 Neutral PMS2 P54278 F788H 788 F H 0.104 Neutral PMS2 P54278 F788I 788 F I 0.122 Neutral PMS2 P54278 F788K 788 F K 0.258 Neutral PMS2 P54278 F788L 788 F L 0.102 Neutral PMS2 P54278 F788M 788 F M 0.118 Neutral PMS2 P54278 F788N 788 F N 0.244 Neutral PMS2 P54278 F788P 788 F P 0.236 Neutral PMS2 P54278 F788Q 788 F Q 0.248 Neutral PMS2 P54278 F788R 788 F R 0.222 Neutral PMS2 P54278 F788S 788 F S 0.258 Neutral PMS2 P54278 F788T 788 F T 0.226 Neutral PMS2 P54278 F788V 788 F V 0.226 Neutral PMS2 P54278 F788W 788 F W 0.46 Neutral PMS2 P54278 F788Y 788 F Y 0.168 Neutral PMS2 P54278 M789A 789 M A 0.108 Neutral PMS2 P54278 M789C 789 M C 0.068 Neutral PMS2 P54278 M789D 789 M D 0.228 Neutral PMS2 P54278 M789E 789 M E 0.104 Neutral PMS2 P54278 M789F 789 M F 0.344 Neutral PMS2 P54278 M789G 789 M G 0.174 Neutral PMS2 P54278 M789H 789 M H 0.096 Neutral PMS2 P54278 M789I 789 M I 0.18 Neutral PMS2 P54278 M789K 789 M K 0.156 Neutral PMS2 P54278 M789L 789 M L 0.118 Neutral PMS2 P54278 M789N 789 M N 0.268 Neutral PMS2 P54278 M789P 789 M P 0.408 Neutral PMS2 P54278 M789Q 789 M Q 0.056 Neutral PMS2 P54278 M789R 789 M R 0.268 Neutral PMS2 P54278 M789S 789 M S 0.222 Neutral PMS2 P54278 M789T 789 M T 0.272 Neutral PMS2 P54278 M789V 789 M V 0.094 Neutral PMS2 P54278 M789W 789 M W 0.668 Pathogenic PMS2 P54278 M789Y 789 M Y 0.574 Pathogenic PMS2 P54278 N79A 79 N A 0.278 Neutral PMS2 P54278 N79C 79 N C 0.72 Pathogenic PMS2 P54278 N79D 79 N D 0.23 Neutral PMS2 P54278 N79E 79 N E 0.234 Neutral PMS2 P54278 N79F 79 N F 0.962 Pathogenic PMS2 P54278 N79G 79 N G 0.192 Neutral PMS2 P54278 N79H 79 N H 0.894 Pathogenic PMS2 P54278 N79I 79 N I 0.938 Pathogenic PMS2 P54278 N79K 79 N K 0.4 Neutral PMS2 P54278 N79L 79 N L 0.95 Pathogenic PMS2 P54278 N79M 79 N M 0.942 Pathogenic PMS2 P54278 N79P 79 N P 0.454 Neutral PMS2 P54278 N79Q 79 N Q 0.286 Neutral PMS2 P54278 N79R 79 N R 0.596 Pathogenic PMS2 P54278 N79S 79 N S 0.194 Neutral PMS2 P54278 N79T 79 N T 0.316 Neutral PMS2 P54278 N79V 79 N V 0.974 Pathogenic PMS2 P54278 N79W 79 N W 0.968 Pathogenic PMS2 P54278 N79Y 79 N Y 0.962 Pathogenic PMS2 P54278 L790A 790 L A 0.124 Neutral PMS2 P54278 L790C 790 L C 0.13 Neutral PMS2 P54278 L790D 790 L D 0.23 Neutral PMS2 P54278 L790E 790 L E 0.226 Neutral PMS2 P54278 L790F 790 L F 0.366 Neutral PMS2 P54278 L790G 790 L G 0.242 Neutral PMS2 P54278 L790H 790 L H 0.122 Neutral PMS2 P54278 L790I 790 L I 0.112 Neutral PMS2 P54278 L790K 790 L K 0.176 Neutral PMS2 P54278 L790M 790 L M 0.186 Neutral PMS2 P54278 L790N 790 L N 0.216 Neutral PMS2 P54278 L790P 790 L P 0.334 Neutral PMS2 P54278 L790Q 790 L Q 0.1 Neutral PMS2 P54278 L790R 790 L R 0.428 Neutral PMS2 P54278 L790S 790 L S 0.256 Neutral PMS2 P54278 L790T 790 L T 0.17 Neutral PMS2 P54278 L790V 790 L V 0.176 Neutral PMS2 P54278 L790W 790 L W 0.526 Pathogenic PMS2 P54278 L790Y 790 L Y 0.488 Neutral PMS2 P54278 S791A 791 S A 0.086 Neutral PMS2 P54278 S791C 791 S C 0.066 Neutral PMS2 P54278 S791D 791 S D 0.108 Neutral PMS2 P54278 S791E 791 S E 0.272 Neutral PMS2 P54278 S791F 791 S F 0.504 Pathogenic PMS2 P54278 S791G 791 S G 0.108 Neutral PMS2 P54278 S791H 791 S H 0.43 Neutral PMS2 P54278 S791I 791 S I 0.156 Neutral PMS2 P54278 S791K 791 S K 0.358 Neutral PMS2 P54278 S791L 791 S L 0.16 Neutral PMS2 P54278 S791M 791 S M 0.612 Pathogenic PMS2 P54278 S791N 791 S N 0.058 Neutral PMS2 P54278 S791P 791 S P 0.206 Neutral PMS2 P54278 S791Q 791 S Q 0.316 Neutral PMS2 P54278 S791R 791 S R 0.34 Neutral PMS2 P54278 S791T 791 S T 0.258 Neutral PMS2 P54278 S791V 791 S V 0.394 Neutral PMS2 P54278 S791W 791 S W 0.728 Pathogenic PMS2 P54278 S791Y 791 S Y 0.688 Pathogenic PMS2 P54278 D792A 792 D A 0.128 Neutral PMS2 P54278 D792C 792 D C 0.252 Neutral PMS2 P54278 D792E 792 D E 0.238 Neutral PMS2 P54278 D792F 792 D F 0.612 Pathogenic PMS2 P54278 D792G 792 D G 0.196 Neutral PMS2 P54278 D792H 792 D H 0.154 Neutral PMS2 P54278 D792I 792 D I 0.422 Neutral PMS2 P54278 D792K 792 D K 0.294 Neutral PMS2 P54278 D792L 792 D L 0.414 Neutral PMS2 P54278 D792M 792 D M 0.324 Neutral PMS2 P54278 D792N 792 D N 0.088 Neutral PMS2 P54278 D792P 792 D P 0.434 Neutral PMS2 P54278 D792Q 792 D Q 0.172 Neutral PMS2 P54278 D792R 792 D R 0.28 Neutral PMS2 P54278 D792S 792 D S 0.208 Neutral PMS2 P54278 D792T 792 D T 0.19 Neutral PMS2 P54278 D792V 792 D V 0.386 Neutral PMS2 P54278 D792W 792 D W 0.698 Pathogenic PMS2 P54278 D792Y 792 D Y 0.67 Pathogenic PMS2 P54278 S793A 793 S A 0.052 Neutral PMS2 P54278 S793C 793 S C 0.002 Neutral PMS2 P54278 S793D 793 S D 0.048 Neutral PMS2 P54278 S793E 793 S E 0.182 Neutral PMS2 P54278 S793F 793 S F 0.326 Neutral PMS2 P54278 S793G 793 S G 0.036 Neutral PMS2 P54278 S793H 793 S H 0.278 Neutral PMS2 P54278 S793I 793 S I 0.042 Neutral PMS2 P54278 S793K 793 S K 0.176 Neutral PMS2 P54278 S793L 793 S L 0.044 Neutral PMS2 P54278 S793M 793 S M 0.406 Neutral PMS2 P54278 S793N 793 S N 0.016 Neutral PMS2 P54278 S793P 793 S P 0.124 Neutral PMS2 P54278 S793Q 793 S Q 0.192 Neutral PMS2 P54278 S793R 793 S R 0.21 Neutral PMS2 P54278 S793T 793 S T 0.114 Neutral PMS2 P54278 S793V 793 S V 0.266 Neutral PMS2 P54278 S793W 793 S W 0.548 Pathogenic PMS2 P54278 S793Y 793 S Y 0.504 Pathogenic PMS2 P54278 P794A 794 P A 0.248 Neutral PMS2 P54278 P794C 794 P C 0.242 Neutral PMS2 P54278 P794D 794 P D 0.136 Neutral PMS2 P54278 P794E 794 P E 0.37 Neutral PMS2 P54278 P794F 794 P F 0.524 Pathogenic PMS2 P54278 P794G 794 P G 0.138 Neutral PMS2 P54278 P794H 794 P H 0.484 Neutral PMS2 P54278 P794I 794 P I 0.22 Neutral PMS2 P54278 P794K 794 P K 0.3 Neutral PMS2 P54278 P794L 794 P L 0.18 Neutral PMS2 P54278 P794M 794 P M 0.388 Neutral PMS2 P54278 P794N 794 P N 0.106 Neutral PMS2 P54278 P794Q 794 P Q 0.372 Neutral PMS2 P54278 P794R 794 P R 0.43 Neutral PMS2 P54278 P794S 794 P S 0.172 Neutral PMS2 P54278 P794T 794 P T 0.196 Neutral PMS2 P54278 P794V 794 P V 0.224 Neutral PMS2 P54278 P794W 794 P W 0.62 Pathogenic PMS2 P54278 P794Y 794 P Y 0.552 Pathogenic PMS2 P54278 G795A 795 G A 0.166 Neutral PMS2 P54278 G795C 795 G C 0.37 Neutral PMS2 P54278 G795D 795 G D 0.434 Neutral PMS2 P54278 G795E 795 G E 0.432 Neutral PMS2 P54278 G795F 795 G F 0.772 Pathogenic PMS2 P54278 G795H 795 G H 0.716 Pathogenic PMS2 P54278 G795I 795 G I 0.688 Pathogenic PMS2 P54278 G795K 795 G K 0.698 Pathogenic PMS2 P54278 G795L 795 G L 0.688 Pathogenic PMS2 P54278 G795M 795 G M 0.706 Pathogenic PMS2 P54278 G795N 795 G N 0.334 Neutral PMS2 P54278 G795P 795 G P 0.646 Pathogenic PMS2 P54278 G795Q 795 G Q 0.46 Neutral PMS2 P54278 G795R 795 G R 0.764 Pathogenic PMS2 P54278 G795S 795 G S 0.296 Neutral PMS2 P54278 G795T 795 G T 0.478 Neutral PMS2 P54278 G795V 795 G V 0.668 Pathogenic PMS2 P54278 G795W 795 G W 0.77 Pathogenic PMS2 P54278 G795Y 795 G Y 0.754 Pathogenic PMS2 P54278 V796A 796 V A 0.072 Neutral PMS2 P54278 V796C 796 V C 0.108 Neutral PMS2 P54278 V796D 796 V D 0.192 Neutral PMS2 P54278 V796E 796 V E 0.33 Neutral PMS2 P54278 V796F 796 V F 0.364 Neutral PMS2 P54278 V796G 796 V G 0.276 Neutral PMS2 P54278 V796H 796 V H 0.232 Neutral PMS2 P54278 V796I 796 V I 0.01 Neutral PMS2 P54278 V796K 796 V K 0.296 Neutral PMS2 P54278 V796L 796 V L 0.04 Neutral PMS2 P54278 V796M 796 V M 0.176 Neutral PMS2 P54278 V796N 796 V N 0.218 Neutral PMS2 P54278 V796P 796 V P 0.332 Neutral PMS2 P54278 V796Q 796 V Q 0.352 Neutral PMS2 P54278 V796R 796 V R 0.488 Neutral PMS2 P54278 V796S 796 V S 0.146 Neutral PMS2 P54278 V796T 796 V T 0.13 Neutral PMS2 P54278 V796W 796 V W 0.536 Pathogenic PMS2 P54278 V796Y 796 V Y 0.456 Neutral PMS2 P54278 M797A 797 M A 0.114 Neutral PMS2 P54278 M797C 797 M C 0.078 Neutral PMS2 P54278 M797D 797 M D 0.24 Neutral PMS2 P54278 M797E 797 M E 0.072 Neutral PMS2 P54278 M797F 797 M F 0.362 Neutral PMS2 P54278 M797G 797 M G 0.186 Neutral PMS2 P54278 M797H 797 M H 0.102 Neutral PMS2 P54278 M797I 797 M I 0.198 Neutral PMS2 P54278 M797K 797 M K 0.124 Neutral PMS2 P54278 M797L 797 M L 0.186 Neutral PMS2 P54278 M797N 797 M N 0.28 Neutral PMS2 P54278 M797P 797 M P 0.428 Neutral PMS2 P54278 M797Q 797 M Q 0.106 Neutral PMS2 P54278 M797R 797 M R 0.23 Neutral PMS2 P54278 M797S 797 M S 0.236 Neutral PMS2 P54278 M797T 797 M T 0.22 Neutral PMS2 P54278 M797V 797 M V 0.206 Neutral PMS2 P54278 M797W 797 M W 0.686 Pathogenic PMS2 P54278 M797Y 797 M Y 0.592 Pathogenic PMS2 P54278 C798A 798 C A 0.136 Neutral PMS2 P54278 C798D 798 C D 0.118 Neutral PMS2 P54278 C798E 798 C E 0.22 Neutral PMS2 P54278 C798F 798 C F 0.666 Pathogenic PMS2 P54278 C798G 798 C G 0.238 Neutral PMS2 P54278 C798H 798 C H 0.372 Neutral PMS2 P54278 C798I 798 C I 0.436 Neutral PMS2 P54278 C798K 798 C K 0.328 Neutral PMS2 P54278 C798L 798 C L 0.456 Neutral PMS2 P54278 C798M 798 C M 0.25 Neutral PMS2 P54278 C798N 798 C N 0.072 Neutral PMS2 P54278 C798P 798 C P 0.438 Neutral PMS2 P54278 C798Q 798 C Q 0.224 Neutral PMS2 P54278 C798R 798 C R 0.478 Neutral PMS2 P54278 C798S 798 C S 0.192 Neutral PMS2 P54278 C798T 798 C T 0.178 Neutral PMS2 P54278 C798V 798 C V 0.342 Neutral PMS2 P54278 C798W 798 C W 0.74 Pathogenic PMS2 P54278 C798Y 798 C Y 0.708 Pathogenic PMS2 P54278 R799A 799 R A 0.146 Neutral PMS2 P54278 R799C 799 R C 0.246 Neutral PMS2 P54278 R799D 799 R D 0.262 Neutral PMS2 P54278 R799E 799 R E 0.204 Neutral PMS2 P54278 R799F 799 R F 0.456 Neutral PMS2 P54278 R799G 799 R G 0.102 Neutral PMS2 P54278 R799H 799 R H 0.188 Neutral PMS2 P54278 R799I 799 R I 0.478 Neutral PMS2 P54278 R799K 799 R K 0.28 Neutral PMS2 P54278 R799L 799 R L 0.44 Neutral PMS2 P54278 R799M 799 R M 0.258 Neutral PMS2 P54278 R799N 799 R N 0.254 Neutral PMS2 P54278 R799P 799 R P 0.42 Neutral PMS2 P54278 R799Q 799 R Q 0.234 Neutral PMS2 P54278 R799S 799 R S 0.206 Neutral PMS2 P54278 R799T 799 R T 0.212 Neutral PMS2 P54278 R799V 799 R V 0.388 Neutral PMS2 P54278 R799W 799 R W 0.628 Pathogenic PMS2 P54278 R799Y 799 R Y 0.456 Neutral PMS2 P54278 S8A 8 S A 0.01 Neutral PMS2 P54278 S8C 8 S C 0.002 Neutral PMS2 P54278 S8D 8 S D 0.036 Neutral PMS2 P54278 S8E 8 S E 0.146 Neutral PMS2 P54278 S8F 8 S F 0.328 Neutral PMS2 P54278 S8G 8 S G 0.066 Neutral PMS2 P54278 S8H 8 S H 0.242 Neutral PMS2 P54278 S8I 8 S I 0.042 Neutral PMS2 P54278 S8K 8 S K 0.192 Neutral PMS2 P54278 S8L 8 S L 0.042 Neutral PMS2 P54278 S8M 8 S M 0.364 Neutral PMS2 P54278 S8N 8 S N 0.02 Neutral PMS2 P54278 S8P 8 S P 0.124 Neutral PMS2 P54278 S8Q 8 S Q 0.182 Neutral PMS2 P54278 S8R 8 S R 0.176 Neutral PMS2 P54278 S8T 8 S T 0.02 Neutral PMS2 P54278 S8V 8 S V 0.036 Neutral PMS2 P54278 S8W 8 S W 0.56 Pathogenic PMS2 P54278 S8Y 8 S Y 0.462 Neutral PMS2 P54278 F80A 80 F A 0.126 Neutral PMS2 P54278 F80C 80 F C 0.294 Neutral PMS2 P54278 F80D 80 F D 0.246 Neutral PMS2 P54278 F80E 80 F E 0.662 Pathogenic PMS2 P54278 F80G 80 F G 0.334 Neutral PMS2 P54278 F80H 80 F H 0.336 Neutral PMS2 P54278 F80I 80 F I 0.454 Neutral PMS2 P54278 F80K 80 F K 0.618 Pathogenic PMS2 P54278 F80L 80 F L 0.028 Neutral PMS2 P54278 F80M 80 F M 0.35 Neutral PMS2 P54278 F80N 80 F N 0.558 Pathogenic PMS2 P54278 F80P 80 F P 0.136 Neutral PMS2 P54278 F80Q 80 F Q 0.592 Pathogenic PMS2 P54278 F80R 80 F R 0.644 Pathogenic PMS2 P54278 F80S 80 F S 0.07 Neutral PMS2 P54278 F80T 80 F T 0.414 Neutral PMS2 P54278 F80V 80 F V 0.474 Neutral PMS2 P54278 F80W 80 F W 0.85 Pathogenic PMS2 P54278 F80Y 80 F Y 0.034 Neutral PMS2 P54278 P800A 800 P A 0.258 Neutral PMS2 P54278 P800C 800 P C 0.212 Neutral PMS2 P54278 P800D 800 P D 0.136 Neutral PMS2 P54278 P800E 800 P E 0.37 Neutral PMS2 P54278 P800F 800 P F 0.524 Pathogenic PMS2 P54278 P800G 800 P G 0.138 Neutral PMS2 P54278 P800H 800 P H 0.484 Neutral PMS2 P54278 P800I 800 P I 0.22 Neutral PMS2 P54278 P800K 800 P K 0.364 Neutral PMS2 P54278 P800L 800 P L 0.18 Neutral PMS2 P54278 P800M 800 P M 0.388 Neutral PMS2 P54278 P800N 800 P N 0.106 Neutral PMS2 P54278 P800Q 800 P Q 0.372 Neutral PMS2 P54278 P800R 800 P R 0.538 Pathogenic PMS2 P54278 P800S 800 P S 0.172 Neutral PMS2 P54278 P800T 800 P T 0.196 Neutral PMS2 P54278 P800V 800 P V 0.224 Neutral PMS2 P54278 P800W 800 P W 0.62 Pathogenic PMS2 P54278 P800Y 800 P Y 0.512 Pathogenic PMS2 P54278 S801A 801 S A 0.144 Neutral PMS2 P54278 S801C 801 S C 0.076 Neutral PMS2 P54278 S801D 801 S D 0.118 Neutral PMS2 P54278 S801E 801 S E 0.33 Neutral PMS2 P54278 S801F 801 S F 0.52 Pathogenic PMS2 P54278 S801G 801 S G 0.12 Neutral PMS2 P54278 S801H 801 S H 0.446 Neutral PMS2 P54278 S801I 801 S I 0.17 Neutral PMS2 P54278 S801K 801 S K 0.374 Neutral PMS2 P54278 S801L 801 S L 0.174 Neutral PMS2 P54278 S801M 801 S M 0.628 Pathogenic PMS2 P54278 S801N 801 S N 0.1 Neutral PMS2 P54278 S801P 801 S P 0.214 Neutral PMS2 P54278 S801Q 801 S Q 0.32 Neutral PMS2 P54278 S801R 801 S R 0.352 Neutral PMS2 P54278 S801T 801 S T 0.264 Neutral PMS2 P54278 S801V 801 S V 0.41 Neutral PMS2 P54278 S801W 801 S W 0.744 Pathogenic PMS2 P54278 S801Y 801 S Y 0.702 Pathogenic PMS2 P54278 R802A 802 R A 0.146 Neutral PMS2 P54278 R802C 802 R C 0.246 Neutral PMS2 P54278 R802D 802 R D 0.262 Neutral PMS2 P54278 R802E 802 R E 0.204 Neutral PMS2 P54278 R802F 802 R F 0.456 Neutral PMS2 P54278 R802G 802 R G 0.102 Neutral PMS2 P54278 R802H 802 R H 0.188 Neutral PMS2 P54278 R802I 802 R I 0.478 Neutral PMS2 P54278 R802K 802 R K 0.11 Neutral PMS2 P54278 R802L 802 R L 0.44 Neutral PMS2 P54278 R802M 802 R M 0.258 Neutral PMS2 P54278 R802N 802 R N 0.254 Neutral PMS2 P54278 R802P 802 R P 0.42 Neutral PMS2 P54278 R802Q 802 R Q 0.234 Neutral PMS2 P54278 R802S 802 R S 0.206 Neutral PMS2 P54278 R802T 802 R T 0.212 Neutral PMS2 P54278 R802V 802 R V 0.388 Neutral PMS2 P54278 R802W 802 R W 0.628 Pathogenic PMS2 P54278 R802Y 802 R Y 0.456 Neutral PMS2 P54278 V803A 803 V A 0.062 Neutral PMS2 P54278 V803C 803 V C 0.104 Neutral PMS2 P54278 V803D 803 V D 0.198 Neutral PMS2 P54278 V803E 803 V E 0.328 Neutral PMS2 P54278 V803F 803 V F 0.308 Neutral PMS2 P54278 V803G 803 V G 0.276 Neutral PMS2 P54278 V803H 803 V H 0.226 Neutral PMS2 P54278 V803I 803 V I 0.052 Neutral PMS2 P54278 V803K 803 V K 0.298 Neutral PMS2 P54278 V803L 803 V L 0.114 Neutral PMS2 P54278 V803M 803 V M 0.17 Neutral PMS2 P54278 V803N 803 V N 0.216 Neutral PMS2 P54278 V803P 803 V P 0.334 Neutral PMS2 P54278 V803Q 803 V Q 0.352 Neutral PMS2 P54278 V803R 803 V R 0.486 Neutral PMS2 P54278 V803S 803 V S 0.142 Neutral PMS2 P54278 V803T 803 V T 0.124 Neutral PMS2 P54278 V803W 803 V W 0.534 Pathogenic PMS2 P54278 V803Y 803 V Y 0.452 Neutral PMS2 P54278 K804A 804 K A 0.088 Neutral PMS2 P54278 K804C 804 K C 0.062 Neutral PMS2 P54278 K804D 804 K D 0.102 Neutral PMS2 P54278 K804E 804 K E 0.112 Neutral PMS2 P54278 K804F 804 K F 0.368 Neutral PMS2 P54278 K804G 804 K G 0.186 Neutral PMS2 P54278 K804H 804 K H 0.086 Neutral PMS2 P54278 K804I 804 K I 0.4 Neutral PMS2 P54278 K804L 804 K L 0.384 Neutral PMS2 P54278 K804M 804 K M 0.194 Neutral PMS2 P54278 K804N 804 K N 0.124 Neutral PMS2 P54278 K804P 804 K P 0.392 Neutral PMS2 P54278 K804Q 804 K Q 0.132 Neutral PMS2 P54278 K804R 804 K R 0.014 Neutral PMS2 P54278 K804S 804 K S 0.244 Neutral PMS2 P54278 K804T 804 K T 0.15 Neutral PMS2 P54278 K804V 804 K V 0.302 Neutral PMS2 P54278 K804W 804 K W 0.682 Pathogenic PMS2 P54278 K804Y 804 K Y 0.586 Pathogenic PMS2 P54278 Q805A 805 Q A 0.172 Neutral PMS2 P54278 Q805C 805 Q C 0.162 Neutral PMS2 P54278 Q805D 805 Q D 0.144 Neutral PMS2 P54278 Q805E 805 Q E 0.154 Neutral PMS2 P54278 Q805F 805 Q F 0.43 Neutral PMS2 P54278 Q805G 805 Q G 0.188 Neutral PMS2 P54278 Q805H 805 Q H 0.36 Neutral PMS2 P54278 Q805I 805 Q I 0.45 Neutral PMS2 P54278 Q805K 805 Q K 0.356 Neutral PMS2 P54278 Q805L 805 Q L 0.398 Neutral PMS2 P54278 Q805M 805 Q M 0.336 Neutral PMS2 P54278 Q805N 805 Q N 0.11 Neutral PMS2 P54278 Q805P 805 Q P 0.464 Neutral PMS2 P54278 Q805R 805 Q R 0.112 Neutral PMS2 P54278 Q805S 805 Q S 0.272 Neutral PMS2 P54278 Q805T 805 Q T 0.204 Neutral PMS2 P54278 Q805V 805 Q V 0.434 Neutral PMS2 P54278 Q805W 805 Q W 0.688 Pathogenic PMS2 P54278 Q805Y 805 Q Y 0.616 Pathogenic PMS2 P54278 M806A 806 M A 0.112 Neutral PMS2 P54278 M806C 806 M C 0.076 Neutral PMS2 P54278 M806D 806 M D 0.236 Neutral PMS2 P54278 M806E 806 M E 0.11 Neutral PMS2 P54278 M806F 806 M F 0.358 Neutral PMS2 P54278 M806G 806 M G 0.168 Neutral PMS2 P54278 M806H 806 M H 0.1 Neutral PMS2 P54278 M806I 806 M I 0.194 Neutral PMS2 P54278 M806K 806 M K 0.12 Neutral PMS2 P54278 M806L 806 M L 0.134 Neutral PMS2 P54278 M806N 806 M N 0.276 Neutral PMS2 P54278 M806P 806 M P 0.424 Neutral PMS2 P54278 M806Q 806 M Q 0.102 Neutral PMS2 P54278 M806R 806 M R 0.274 Neutral PMS2 P54278 M806S 806 M S 0.232 Neutral PMS2 P54278 M806T 806 M T 0.216 Neutral PMS2 P54278 M806V 806 M V 0.202 Neutral PMS2 P54278 M806W 806 M W 0.682 Pathogenic PMS2 P54278 M806Y 806 M Y 0.588 Pathogenic PMS2 P54278 F807A 807 F A 0.124 Neutral PMS2 P54278 F807C 807 F C 0.13 Neutral PMS2 P54278 F807D 807 F D 0.242 Neutral PMS2 P54278 F807E 807 F E 0.28 Neutral PMS2 P54278 F807G 807 F G 0.192 Neutral PMS2 P54278 F807H 807 F H 0.108 Neutral PMS2 P54278 F807I 807 F I 0.096 Neutral PMS2 P54278 F807K 807 F K 0.266 Neutral PMS2 P54278 F807L 807 F L 0.064 Neutral PMS2 P54278 F807M 807 F M 0.124 Neutral PMS2 P54278 F807N 807 F N 0.256 Neutral PMS2 P54278 F807P 807 F P 0.278 Neutral PMS2 P54278 F807Q 807 F Q 0.256 Neutral PMS2 P54278 F807R 807 F R 0.228 Neutral PMS2 P54278 F807S 807 F S 0.22 Neutral PMS2 P54278 F807T 807 F T 0.236 Neutral PMS2 P54278 F807V 807 F V 0.236 Neutral PMS2 P54278 F807W 807 F W 0.468 Neutral PMS2 P54278 F807Y 807 F Y 0.174 Neutral PMS2 P54278 A808C 808 A C 0.332 Neutral PMS2 P54278 A808D 808 A D 0.464 Neutral PMS2 P54278 A808E 808 A E 0.506 Pathogenic PMS2 P54278 A808F 808 A F 0.728 Pathogenic PMS2 P54278 A808G 808 A G 0.194 Neutral PMS2 P54278 A808H 808 A H 0.51 Pathogenic PMS2 P54278 A808I 808 A I 0.672 Pathogenic PMS2 P54278 A808K 808 A K 0.594 Pathogenic PMS2 P54278 A808L 808 A L 0.656 Pathogenic PMS2 P54278 A808M 808 A M 0.49 Neutral PMS2 P54278 A808N 808 A N 0.464 Neutral PMS2 P54278 A808P 808 A P 0.466 Neutral PMS2 P54278 A808Q 808 A Q 0.492 Neutral PMS2 P54278 A808R 808 A R 0.586 Pathogenic PMS2 P54278 A808S 808 A S 0.22 Neutral PMS2 P54278 A808T 808 A T 0.288 Neutral PMS2 P54278 A808V 808 A V 0.382 Neutral PMS2 P54278 A808W 808 A W 0.758 Pathogenic PMS2 P54278 A808Y 808 A Y 0.744 Pathogenic PMS2 P54278 S809A 809 S A 0.144 Neutral PMS2 P54278 S809C 809 S C 0.076 Neutral PMS2 P54278 S809D 809 S D 0.118 Neutral PMS2 P54278 S809E 809 S E 0.33 Neutral PMS2 P54278 S809F 809 S F 0.52 Pathogenic PMS2 P54278 S809G 809 S G 0.076 Neutral PMS2 P54278 S809H 809 S H 0.446 Neutral PMS2 P54278 S809I 809 S I 0.17 Neutral PMS2 P54278 S809K 809 S K 0.374 Neutral PMS2 P54278 S809L 809 S L 0.174 Neutral PMS2 P54278 S809M 809 S M 0.564 Pathogenic PMS2 P54278 S809N 809 S N 0.1 Neutral PMS2 P54278 S809P 809 S P 0.218 Neutral PMS2 P54278 S809Q 809 S Q 0.32 Neutral PMS2 P54278 S809R 809 S R 0.446 Neutral PMS2 P54278 S809T 809 S T 0.186 Neutral PMS2 P54278 S809V 809 S V 0.41 Neutral PMS2 P54278 S809W 809 S W 0.744 Pathogenic PMS2 P54278 S809Y 809 S Y 0.702 Pathogenic PMS2 P54278 E81A 81 E A 0.24 Neutral PMS2 P54278 E81C 81 E C 0.44 Neutral PMS2 P54278 E81D 81 E D 0.028 Neutral PMS2 P54278 E81F 81 E F 0.8 Pathogenic PMS2 P54278 E81G 81 E G 0.226 Neutral PMS2 P54278 E81H 81 E H 0.388 Neutral PMS2 P54278 E81I 81 E I 0.87 Pathogenic PMS2 P54278 E81K 81 E K 0.052 Neutral PMS2 P54278 E81L 81 E L 0.85 Pathogenic PMS2 P54278 E81M 81 E M 0.658 Pathogenic PMS2 P54278 E81N 81 E N 0.258 Neutral PMS2 P54278 E81P 81 E P 0.136 Neutral PMS2 P54278 E81Q 81 E Q 0.024 Neutral PMS2 P54278 E81R 81 E R 0.204 Neutral PMS2 P54278 E81S 81 E S 0.042 Neutral PMS2 P54278 E81T 81 E T 0.052 Neutral PMS2 P54278 E81V 81 E V 0.782 Pathogenic PMS2 P54278 E81W 81 E W 0.94 Pathogenic PMS2 P54278 E81Y 81 E Y 0.862 Pathogenic PMS2 P54278 R810A 810 R A 0.146 Neutral PMS2 P54278 R810C 810 R C 0.246 Neutral PMS2 P54278 R810D 810 R D 0.262 Neutral PMS2 P54278 R810E 810 R E 0.204 Neutral PMS2 P54278 R810F 810 R F 0.456 Neutral PMS2 P54278 R810G 810 R G 0.13 Neutral PMS2 P54278 R810H 810 R H 0.188 Neutral PMS2 P54278 R810I 810 R I 0.478 Neutral PMS2 P54278 R810K 810 R K 0.28 Neutral PMS2 P54278 R810L 810 R L 0.44 Neutral PMS2 P54278 R810M 810 R M 0.258 Neutral PMS2 P54278 R810N 810 R N 0.254 Neutral PMS2 P54278 R810P 810 R P 0.42 Neutral PMS2 P54278 R810Q 810 R Q 0.134 Neutral PMS2 P54278 R810S 810 R S 0.206 Neutral PMS2 P54278 R810T 810 R T 0.212 Neutral PMS2 P54278 R810V 810 R V 0.388 Neutral PMS2 P54278 R810W 810 R W 0.628 Pathogenic PMS2 P54278 R810Y 810 R Y 0.456 Neutral PMS2 P54278 A811C 811 A C 0.332 Neutral PMS2 P54278 A811D 811 A D 0.464 Neutral PMS2 P54278 A811E 811 A E 0.49 Neutral PMS2 P54278 A811F 811 A F 0.728 Pathogenic PMS2 P54278 A811G 811 A G 0.194 Neutral PMS2 P54278 A811H 811 A H 0.51 Pathogenic PMS2 P54278 A811I 811 A I 0.672 Pathogenic PMS2 P54278 A811K 811 A K 0.594 Pathogenic PMS2 P54278 A811L 811 A L 0.656 Pathogenic PMS2 P54278 A811M 811 A M 0.49 Neutral PMS2 P54278 A811N 811 A N 0.464 Neutral PMS2 P54278 A811P 811 A P 0.466 Neutral PMS2 P54278 A811Q 811 A Q 0.472 Neutral PMS2 P54278 A811R 811 A R 0.586 Pathogenic PMS2 P54278 A811S 811 A S 0.166 Neutral PMS2 P54278 A811T 811 A T 0.288 Neutral PMS2 P54278 A811V 811 A V 0.382 Neutral PMS2 P54278 A811W 811 A W 0.758 Pathogenic PMS2 P54278 A811Y 811 A Y 0.762 Pathogenic PMS2 P54278 C812A 812 C A 0.136 Neutral PMS2 P54278 C812D 812 C D 0.118 Neutral PMS2 P54278 C812E 812 C E 0.22 Neutral PMS2 P54278 C812F 812 C F 0.666 Pathogenic PMS2 P54278 C812G 812 C G 0.238 Neutral PMS2 P54278 C812H 812 C H 0.372 Neutral PMS2 P54278 C812I 812 C I 0.436 Neutral PMS2 P54278 C812K 812 C K 0.328 Neutral PMS2 P54278 C812L 812 C L 0.402 Neutral PMS2 P54278 C812M 812 C M 0.25 Neutral PMS2 P54278 C812N 812 C N 0.04 Neutral PMS2 P54278 C812P 812 C P 0.438 Neutral PMS2 P54278 C812Q 812 C Q 0.224 Neutral PMS2 P54278 C812R 812 C R 0.478 Neutral PMS2 P54278 C812S 812 C S 0.242 Neutral PMS2 P54278 C812T 812 C T 0.178 Neutral PMS2 P54278 C812V 812 C V 0.342 Neutral PMS2 P54278 C812W 812 C W 0.74 Pathogenic PMS2 P54278 C812Y 812 C Y 0.708 Pathogenic PMS2 P54278 R813A 813 R A 0.146 Neutral PMS2 P54278 R813C 813 R C 0.246 Neutral PMS2 P54278 R813D 813 R D 0.262 Neutral PMS2 P54278 R813E 813 R E 0.204 Neutral PMS2 P54278 R813F 813 R F 0.456 Neutral PMS2 P54278 R813G 813 R G 0.102 Neutral PMS2 P54278 R813H 813 R H 0.216 Neutral PMS2 P54278 R813I 813 R I 0.478 Neutral PMS2 P54278 R813K 813 R K 0.28 Neutral PMS2 P54278 R813L 813 R L 0.44 Neutral PMS2 P54278 R813M 813 R M 0.258 Neutral PMS2 P54278 R813N 813 R N 0.254 Neutral PMS2 P54278 R813P 813 R P 0.42 Neutral PMS2 P54278 R813Q 813 R Q 0.324 Neutral PMS2 P54278 R813S 813 R S 0.206 Neutral PMS2 P54278 R813T 813 R T 0.212 Neutral PMS2 P54278 R813V 813 R V 0.388 Neutral PMS2 P54278 R813W 813 R W 0.628 Pathogenic PMS2 P54278 R813Y 813 R Y 0.456 Neutral PMS2 P54278 K814A 814 K A 0.086 Neutral PMS2 P54278 K814C 814 K C 0.058 Neutral PMS2 P54278 K814D 814 K D 0.1 Neutral PMS2 P54278 K814E 814 K E 0.11 Neutral PMS2 P54278 K814F 814 K F 0.364 Neutral PMS2 P54278 K814G 814 K G 0.182 Neutral PMS2 P54278 K814H 814 K H 0.084 Neutral PMS2 P54278 K814I 814 K I 0.396 Neutral PMS2 P54278 K814L 814 K L 0.38 Neutral PMS2 P54278 K814M 814 K M 0.19 Neutral PMS2 P54278 K814N 814 K N 0.122 Neutral PMS2 P54278 K814P 814 K P 0.388 Neutral PMS2 P54278 K814Q 814 K Q 0.13 Neutral PMS2 P54278 K814R 814 K R 0.118 Neutral PMS2 P54278 K814S 814 K S 0.03 Neutral PMS2 P54278 K814T 814 K T 0.242 Neutral PMS2 P54278 K814V 814 K V 0.298 Neutral PMS2 P54278 K814W 814 K W 0.678 Pathogenic PMS2 P54278 K814Y 814 K Y 0.582 Pathogenic PMS2 P54278 S815A 815 S A 0.098 Neutral PMS2 P54278 S815C 815 S C 0.076 Neutral PMS2 P54278 S815D 815 S D 0.118 Neutral PMS2 P54278 S815E 815 S E 0.33 Neutral PMS2 P54278 S815F 815 S F 0.52 Pathogenic PMS2 P54278 S815G 815 S G 0.12 Neutral PMS2 P54278 S815H 815 S H 0.446 Neutral PMS2 P54278 S815I 815 S I 0.17 Neutral PMS2 P54278 S815K 815 S K 0.374 Neutral PMS2 P54278 S815L 815 S L 0.174 Neutral PMS2 P54278 S815M 815 S M 0.628 Pathogenic PMS2 P54278 S815N 815 S N 0.1 Neutral PMS2 P54278 S815P 815 S P 0.214 Neutral PMS2 P54278 S815Q 815 S Q 0.28 Neutral PMS2 P54278 S815R 815 S R 0.446 Neutral PMS2 P54278 S815T 815 S T 0.186 Neutral PMS2 P54278 S815V 815 S V 0.41 Neutral PMS2 P54278 S815W 815 S W 0.744 Pathogenic PMS2 P54278 S815Y 815 S Y 0.702 Pathogenic PMS2 P54278 V816A 816 V A 0.056 Neutral PMS2 P54278 V816C 816 V C 0.114 Neutral PMS2 P54278 V816D 816 V D 0.202 Neutral PMS2 P54278 V816E 816 V E 0.338 Neutral PMS2 P54278 V816F 816 V F 0.378 Neutral PMS2 P54278 V816G 816 V G 0.29 Neutral PMS2 P54278 V816H 816 V H 0.234 Neutral PMS2 P54278 V816I 816 V I 0.024 Neutral PMS2 P54278 V816K 816 V K 0.306 Neutral PMS2 P54278 V816L 816 V L 0.132 Neutral PMS2 P54278 V816M 816 V M 0.124 Neutral PMS2 P54278 V816N 816 V N 0.226 Neutral PMS2 P54278 V816P 816 V P 0.354 Neutral PMS2 P54278 V816Q 816 V Q 0.362 Neutral PMS2 P54278 V816R 816 V R 0.498 Neutral PMS2 P54278 V816S 816 V S 0.152 Neutral PMS2 P54278 V816T 816 V T 0.132 Neutral PMS2 P54278 V816W 816 V W 0.556 Pathogenic PMS2 P54278 V816Y 816 V Y 0.474 Neutral PMS2 P54278 M817A 817 M A 0.114 Neutral PMS2 P54278 M817C 817 M C 0.078 Neutral PMS2 P54278 M817D 817 M D 0.24 Neutral PMS2 P54278 M817E 817 M E 0.072 Neutral PMS2 P54278 M817F 817 M F 0.362 Neutral PMS2 P54278 M817G 817 M G 0.172 Neutral PMS2 P54278 M817H 817 M H 0.102 Neutral PMS2 P54278 M817I 817 M I 0.158 Neutral PMS2 P54278 M817K 817 M K 0.104 Neutral PMS2 P54278 M817L 817 M L 0.186 Neutral PMS2 P54278 M817N 817 M N 0.28 Neutral PMS2 P54278 M817P 817 M P 0.428 Neutral PMS2 P54278 M817Q 817 M Q 0.106 Neutral PMS2 P54278 M817R 817 M R 0.278 Neutral PMS2 P54278 M817S 817 M S 0.236 Neutral PMS2 P54278 M817T 817 M T 0.22 Neutral PMS2 P54278 M817V 817 M V 0.206 Neutral PMS2 P54278 M817W 817 M W 0.686 Pathogenic PMS2 P54278 M817Y 817 M Y 0.592 Pathogenic PMS2 P54278 I818A 818 I A 0.108 Neutral PMS2 P54278 I818C 818 I C 0.14 Neutral PMS2 P54278 I818D 818 I D 0.218 Neutral PMS2 P54278 I818E 818 I E 0.208 Neutral PMS2 P54278 I818F 818 I F 0.342 Neutral PMS2 P54278 I818G 818 I G 0.288 Neutral PMS2 P54278 I818H 818 I H 0.146 Neutral PMS2 P54278 I818K 818 I K 0.222 Neutral PMS2 P54278 I818L 818 I L 0.018 Neutral PMS2 P54278 I818M 818 I M 0.166 Neutral PMS2 P54278 I818N 818 I N 0.258 Neutral PMS2 P54278 I818P 818 I P 0.252 Neutral PMS2 P54278 I818Q 818 I Q 0.258 Neutral PMS2 P54278 I818R 818 I R 0.47 Neutral PMS2 P54278 I818S 818 I S 0.216 Neutral PMS2 P54278 I818T 818 I T 0.164 Neutral PMS2 P54278 I818V 818 I V 0.028 Neutral PMS2 P54278 I818W 818 I W 0.538 Pathogenic PMS2 P54278 I818Y 818 I Y 0.496 Neutral PMS2 P54278 G819A 819 G A 0.166 Neutral PMS2 P54278 G819C 819 G C 0.37 Neutral PMS2 P54278 G819D 819 G D 0.434 Neutral PMS2 P54278 G819E 819 G E 0.574 Pathogenic PMS2 P54278 G819F 819 G F 0.772 Pathogenic PMS2 P54278 G819H 819 G H 0.716 Pathogenic PMS2 P54278 G819I 819 G I 0.572 Pathogenic PMS2 P54278 G819K 819 G K 0.64 Pathogenic PMS2 P54278 G819L 819 G L 0.688 Pathogenic PMS2 P54278 G819M 819 G M 0.706 Pathogenic PMS2 P54278 G819N 819 G N 0.428 Neutral PMS2 P54278 G819P 819 G P 0.646 Pathogenic PMS2 P54278 G819Q 819 G Q 0.46 Neutral PMS2 P54278 G819R 819 G R 0.764 Pathogenic PMS2 P54278 G819S 819 G S 0.296 Neutral PMS2 P54278 G819T 819 G T 0.478 Neutral PMS2 P54278 G819V 819 G V 0.668 Pathogenic PMS2 P54278 G819W 819 G W 0.77 Pathogenic PMS2 P54278 G819Y 819 G Y 0.754 Pathogenic PMS2 P54278 G82A 82 G A 0.05 Neutral PMS2 P54278 G82C 82 G C 0.602 Pathogenic PMS2 P54278 G82D 82 G D 0.34 Neutral PMS2 P54278 G82E 82 G E 0.802 Pathogenic PMS2 P54278 G82F 82 G F 0.906 Pathogenic PMS2 P54278 G82H 82 G H 0.894 Pathogenic PMS2 P54278 G82I 82 G I 0.856 Pathogenic PMS2 P54278 G82K 82 G K 0.87 Pathogenic PMS2 P54278 G82L 82 G L 0.88 Pathogenic PMS2 P54278 G82M 82 G M 0.85 Pathogenic PMS2 P54278 G82N 82 G N 0.628 Pathogenic PMS2 P54278 G82P 82 G P 0.878 Pathogenic PMS2 P54278 G82Q 82 G Q 0.688 Pathogenic PMS2 P54278 G82R 82 G R 0.906 Pathogenic PMS2 P54278 G82S 82 G S 0.082 Neutral PMS2 P54278 G82T 82 G T 0.63 Pathogenic PMS2 P54278 G82V 82 G V 0.692 Pathogenic PMS2 P54278 G82W 82 G W 0.902 Pathogenic PMS2 P54278 G82Y 82 G Y 0.894 Pathogenic PMS2 P54278 T820A 820 T A 0.134 Neutral PMS2 P54278 T820C 820 T C 0.122 Neutral PMS2 P54278 T820D 820 T D 0.12 Neutral PMS2 P54278 T820E 820 T E 0.182 Neutral PMS2 P54278 T820F 820 T F 0.43 Neutral PMS2 P54278 T820G 820 T G 0.1 Neutral PMS2 P54278 T820H 820 T H 0.224 Neutral PMS2 P54278 T820I 820 T I 0.166 Neutral PMS2 P54278 T820K 820 T K 0.128 Neutral PMS2 P54278 T820L 820 T L 0.18 Neutral PMS2 P54278 T820M 820 T M 0.288 Neutral PMS2 P54278 T820N 820 T N 0.02 Neutral PMS2 P54278 T820P 820 T P 0.234 Neutral PMS2 P54278 T820Q 820 T Q 0.06 Neutral PMS2 P54278 T820R 820 T R 0.45 Neutral PMS2 P54278 T820S 820 T S 0.094 Neutral PMS2 P54278 T820V 820 T V 0.35 Neutral PMS2 P54278 T820W 820 T W 0.724 Pathogenic PMS2 P54278 T820Y 820 T Y 0.684 Pathogenic PMS2 P54278 A821C 821 A C 0.336 Neutral PMS2 P54278 A821D 821 A D 0.468 Neutral PMS2 P54278 A821E 821 A E 0.494 Neutral PMS2 P54278 A821F 821 A F 0.732 Pathogenic PMS2 P54278 A821G 821 A G 0.198 Neutral PMS2 P54278 A821H 821 A H 0.514 Pathogenic PMS2 P54278 A821I 821 A I 0.676 Pathogenic PMS2 P54278 A821K 821 A K 0.598 Pathogenic PMS2 P54278 A821L 821 A L 0.66 Pathogenic PMS2 P54278 A821M 821 A M 0.494 Neutral PMS2 P54278 A821N 821 A N 0.468 Neutral PMS2 P54278 A821P 821 A P 0.076 Neutral PMS2 P54278 A821Q 821 A Q 0.496 Neutral PMS2 P54278 A821R 821 A R 0.59 Pathogenic PMS2 P54278 A821S 821 A S 0.17 Neutral PMS2 P54278 A821T 821 A T 0.292 Neutral PMS2 P54278 A821V 821 A V 0.386 Neutral PMS2 P54278 A821W 821 A W 0.762 Pathogenic PMS2 P54278 A821Y 821 A Y 0.766 Pathogenic PMS2 P54278 L822A 822 L A 0.132 Neutral PMS2 P54278 L822C 822 L C 0.136 Neutral PMS2 P54278 L822D 822 L D 0.252 Neutral PMS2 P54278 L822E 822 L E 0.234 Neutral PMS2 P54278 L822F 822 L F 0.374 Neutral PMS2 P54278 L822G 822 L G 0.266 Neutral PMS2 P54278 L822H 822 L H 0.128 Neutral PMS2 P54278 L822I 822 L I 0.066 Neutral PMS2 P54278 L822K 822 L K 0.182 Neutral PMS2 P54278 L822M 822 L M 0.192 Neutral PMS2 P54278 L822N 822 L N 0.244 Neutral PMS2 P54278 L822P 822 L P 0.344 Neutral PMS2 P54278 L822Q 822 L Q 0.104 Neutral PMS2 P54278 L822R 822 L R 0.506 Pathogenic PMS2 P54278 L822S 822 L S 0.198 Neutral PMS2 P54278 L822T 822 L T 0.178 Neutral PMS2 P54278 L822V 822 L V 0.184 Neutral PMS2 P54278 L822W 822 L W 0.536 Pathogenic PMS2 P54278 L822Y 822 L Y 0.498 Neutral PMS2 P54278 N823A 823 N A 0.14 Neutral PMS2 P54278 N823C 823 N C 0.186 Neutral PMS2 P54278 N823D 823 N D 0.112 Neutral PMS2 P54278 N823E 823 N E 0.128 Neutral PMS2 P54278 N823F 823 N F 0.496 Neutral PMS2 P54278 N823G 823 N G 0.188 Neutral PMS2 P54278 N823H 823 N H 0.292 Neutral PMS2 P54278 N823I 823 N I 0.354 Neutral PMS2 P54278 N823K 823 N K 0.288 Neutral PMS2 P54278 N823L 823 N L 0.354 Neutral PMS2 P54278 N823M 823 N M 0.294 Neutral PMS2 P54278 N823P 823 N P 0.316 Neutral PMS2 P54278 N823Q 823 N Q 0.142 Neutral PMS2 P54278 N823R 823 N R 0.302 Neutral PMS2 P54278 N823S 823 N S 0.004 Neutral PMS2 P54278 N823T 823 N T 0.014 Neutral PMS2 P54278 N823V 823 N V 0.364 Neutral PMS2 P54278 N823W 823 N W 0.628 Pathogenic PMS2 P54278 N823Y 823 N Y 0.584 Pathogenic PMS2 P54278 T824A 824 T A 0 Neutral PMS2 P54278 T824C 824 T C 0.064 Neutral PMS2 P54278 T824D 824 T D 0.058 Neutral PMS2 P54278 T824E 824 T E 0.062 Neutral PMS2 P54278 T824F 824 T F 0.214 Neutral PMS2 P54278 T824G 824 T G 0.058 Neutral PMS2 P54278 T824H 824 T H 0.056 Neutral PMS2 P54278 T824I 824 T I 0.076 Neutral PMS2 P54278 T824K 824 T K 0.008 Neutral PMS2 P54278 T824L 824 T L 0.016 Neutral PMS2 P54278 T824M 824 T M 0.044 Neutral PMS2 P54278 T824N 824 T N 0.052 Neutral PMS2 P54278 T824P 824 T P 0.084 Neutral PMS2 P54278 T824Q 824 T Q 0.052 Neutral PMS2 P54278 T824R 824 T R 0.174 Neutral PMS2 P54278 T824S 824 T S 0.024 Neutral PMS2 P54278 T824V 824 T V 0.016 Neutral PMS2 P54278 T824W 824 T W 0.466 Neutral PMS2 P54278 T824Y 824 T Y 0.424 Neutral PMS2 P54278 S825A 825 S A 0.052 Neutral PMS2 P54278 S825C 825 S C 0.032 Neutral PMS2 P54278 S825D 825 S D 0.024 Neutral PMS2 P54278 S825E 825 S E 0.148 Neutral PMS2 P54278 S825F 825 S F 0.276 Neutral PMS2 P54278 S825G 825 S G 0 Neutral PMS2 P54278 S825H 825 S H 0.188 Neutral PMS2 P54278 S825I 825 S I 0.026 Neutral PMS2 P54278 S825K 825 S K 0.14 Neutral PMS2 P54278 S825L 825 S L 0.028 Neutral PMS2 P54278 S825M 825 S M 0.332 Neutral PMS2 P54278 S825N 825 S N 0 Neutral PMS2 P54278 S825P 825 S P 0.116 Neutral PMS2 P54278 S825Q 825 S Q 0.188 Neutral PMS2 P54278 S825R 825 S R 0.248 Neutral PMS2 P54278 S825T 825 S T 0.104 Neutral PMS2 P54278 S825V 825 S V 0.248 Neutral PMS2 P54278 S825W 825 S W 0.49 Neutral PMS2 P54278 S825Y 825 S Y 0.448 Neutral PMS2 P54278 E826A 826 E A 0.184 Neutral PMS2 P54278 E826C 826 E C 0.13 Neutral PMS2 P54278 E826D 826 E D 0.142 Neutral PMS2 P54278 E826F 826 E F 0.44 Neutral PMS2 P54278 E826G 826 E G 0.086 Neutral PMS2 P54278 E826H 826 E H 0.18 Neutral PMS2 P54278 E826I 826 E I 0.464 Neutral PMS2 P54278 E826K 826 E K 0.276 Neutral PMS2 P54278 E826L 826 E L 0.462 Neutral PMS2 P54278 E826M 826 E M 0.302 Neutral PMS2 P54278 E826N 826 E N 0.094 Neutral PMS2 P54278 E826P 826 E P 0.474 Neutral PMS2 P54278 E826Q 826 E Q 0.092 Neutral PMS2 P54278 E826R 826 E R 0.074 Neutral PMS2 P54278 E826S 826 E S 0.234 Neutral PMS2 P54278 E826T 826 E T 0.228 Neutral PMS2 P54278 E826V 826 E V 0.412 Neutral PMS2 P54278 E826W 826 E W 0.712 Pathogenic PMS2 P54278 E826Y 826 E Y 0.598 Pathogenic PMS2 P54278 M827A 827 M A 0.112 Neutral PMS2 P54278 M827C 827 M C 0.076 Neutral PMS2 P54278 M827D 827 M D 0.236 Neutral PMS2 P54278 M827E 827 M E 0.11 Neutral PMS2 P54278 M827F 827 M F 0.358 Neutral PMS2 P54278 M827G 827 M G 0.168 Neutral PMS2 P54278 M827H 827 M H 0.1 Neutral PMS2 P54278 M827I 827 M I 0.194 Neutral PMS2 P54278 M827K 827 M K 0.166 Neutral PMS2 P54278 M827L 827 M L 0.184 Neutral PMS2 P54278 M827N 827 M N 0.276 Neutral PMS2 P54278 M827P 827 M P 0.424 Neutral PMS2 P54278 M827Q 827 M Q 0.102 Neutral PMS2 P54278 M827R 827 M R 0.274 Neutral PMS2 P54278 M827S 827 M S 0.232 Neutral PMS2 P54278 M827T 827 M T 0.216 Neutral PMS2 P54278 M827V 827 M V 0.202 Neutral PMS2 P54278 M827W 827 M W 0.682 Pathogenic PMS2 P54278 M827Y 827 M Y 0.588 Pathogenic PMS2 P54278 K828A 828 K A 0.078 Neutral PMS2 P54278 K828C 828 K C 0.048 Neutral PMS2 P54278 K828D 828 K D 0.09 Neutral PMS2 P54278 K828E 828 K E 0.098 Neutral PMS2 P54278 K828F 828 K F 0.284 Neutral PMS2 P54278 K828G 828 K G 0.152 Neutral PMS2 P54278 K828H 828 K H 0.072 Neutral PMS2 P54278 K828I 828 K I 0.308 Neutral PMS2 P54278 K828L 828 K L 0.296 Neutral PMS2 P54278 K828M 828 K M 0.14 Neutral PMS2 P54278 K828N 828 K N 0.11 Neutral PMS2 P54278 K828P 828 K P 0.304 Neutral PMS2 P54278 K828Q 828 K Q 0.058 Neutral PMS2 P54278 K828R 828 K R 0.004 Neutral PMS2 P54278 K828S 828 K S 0.234 Neutral PMS2 P54278 K828T 828 K T 0.194 Neutral PMS2 P54278 K828V 828 K V 0.23 Neutral PMS2 P54278 K828W 828 K W 0.582 Pathogenic PMS2 P54278 K828Y 828 K Y 0.48 Neutral PMS2 P54278 K829A 829 K A 0.106 Neutral PMS2 P54278 K829C 829 K C 0.054 Neutral PMS2 P54278 K829D 829 K D 0.094 Neutral PMS2 P54278 K829E 829 K E 0.104 Neutral PMS2 P54278 K829F 829 K F 0.35 Neutral PMS2 P54278 K829G 829 K G 0.176 Neutral PMS2 P54278 K829H 829 K H 0.08 Neutral PMS2 P54278 K829I 829 K I 0.38 Neutral PMS2 P54278 K829L 829 K L 0.364 Neutral PMS2 P54278 K829M 829 K M 0.184 Neutral PMS2 P54278 K829N 829 K N 0.116 Neutral PMS2 P54278 K829P 829 K P 0.372 Neutral PMS2 P54278 K829Q 829 K Q 0.06 Neutral PMS2 P54278 K829R 829 K R 0.052 Neutral PMS2 P54278 K829S 829 K S 0.23 Neutral PMS2 P54278 K829T 829 K T 0.136 Neutral PMS2 P54278 K829V 829 K V 0.286 Neutral PMS2 P54278 K829W 829 K W 0.662 Pathogenic PMS2 P54278 K829Y 829 K Y 0.568 Pathogenic PMS2 P54278 L83A 83 L A 0.132 Neutral PMS2 P54278 L83C 83 L C 0.136 Neutral PMS2 P54278 L83D 83 L D 0.24 Neutral PMS2 P54278 L83E 83 L E 0.188 Neutral PMS2 P54278 L83F 83 L F 0.416 Neutral PMS2 P54278 L83G 83 L G 0.164 Neutral PMS2 P54278 L83H 83 L H 0.128 Neutral PMS2 P54278 L83I 83 L I 0.122 Neutral PMS2 P54278 L83K 83 L K 0.25 Neutral PMS2 P54278 L83M 83 L M 0.192 Neutral PMS2 P54278 L83N 83 L N 0.226 Neutral PMS2 P54278 L83P 83 L P 0.356 Neutral PMS2 P54278 L83Q 83 L Q 0.08 Neutral PMS2 P54278 L83R 83 L R 0.364 Neutral PMS2 P54278 L83S 83 L S 0.016 Neutral PMS2 P54278 L83T 83 L T 0.114 Neutral PMS2 P54278 L83V 83 L V 0.24 Neutral PMS2 P54278 L83W 83 L W 0.536 Pathogenic PMS2 P54278 L83Y 83 L Y 0.498 Neutral PMS2 P54278 L830A 830 L A 0.134 Neutral PMS2 P54278 L830C 830 L C 0.138 Neutral PMS2 P54278 L830D 830 L D 0.254 Neutral PMS2 P54278 L830E 830 L E 0.236 Neutral PMS2 P54278 L830F 830 L F 0.378 Neutral PMS2 P54278 L830G 830 L G 0.268 Neutral PMS2 P54278 L830H 830 L H 0.13 Neutral PMS2 P54278 L830I 830 L I 0.124 Neutral PMS2 P54278 L830K 830 L K 0.186 Neutral PMS2 P54278 L830M 830 L M 0.196 Neutral PMS2 P54278 L830N 830 L N 0.246 Neutral PMS2 P54278 L830P 830 L P 0.348 Neutral PMS2 P54278 L830Q 830 L Q 0.108 Neutral PMS2 P54278 L830R 830 L R 0.508 Pathogenic PMS2 P54278 L830S 830 L S 0.202 Neutral PMS2 P54278 L830T 830 L T 0.182 Neutral PMS2 P54278 L830V 830 L V 0.024 Neutral PMS2 P54278 L830W 830 L W 0.54 Pathogenic PMS2 P54278 L830Y 830 L Y 0.502 Pathogenic PMS2 P54278 I831A 831 I A 0.072 Neutral PMS2 P54278 I831C 831 I C 0.092 Neutral PMS2 P54278 I831D 831 I D 0.15 Neutral PMS2 P54278 I831E 831 I E 0.144 Neutral PMS2 P54278 I831F 831 I F 0.25 Neutral PMS2 P54278 I831G 831 I G 0.212 Neutral PMS2 P54278 I831H 831 I H 0.088 Neutral PMS2 P54278 I831K 831 I K 0.162 Neutral PMS2 P54278 I831L 831 I L 0 Neutral PMS2 P54278 I831M 831 I M 0.116 Neutral PMS2 P54278 I831N 831 I N 0.186 Neutral PMS2 P54278 I831P 831 I P 0.186 Neutral PMS2 P54278 I831Q 831 I Q 0.188 Neutral PMS2 P54278 I831R 831 I R 0.332 Neutral PMS2 P54278 I831S 831 I S 0.162 Neutral PMS2 P54278 I831T 831 I T 0.114 Neutral PMS2 P54278 I831V 831 I V 0 Neutral PMS2 P54278 I831W 831 I W 0.408 Neutral PMS2 P54278 I831Y 831 I Y 0.362 Neutral PMS2 P54278 T832A 832 T A 0.06 Neutral PMS2 P54278 T832C 832 T C 0.064 Neutral PMS2 P54278 T832D 832 T D 0.058 Neutral PMS2 P54278 T832E 832 T E 0.062 Neutral PMS2 P54278 T832F 832 T F 0.218 Neutral PMS2 P54278 T832G 832 T G 0.058 Neutral PMS2 P54278 T832H 832 T H 0.088 Neutral PMS2 P54278 T832I 832 T I 0.096 Neutral PMS2 P54278 T832K 832 T K 0.042 Neutral PMS2 P54278 T832L 832 T L 0.074 Neutral PMS2 P54278 T832M 832 T M 0.102 Neutral PMS2 P54278 T832N 832 T N 0.02 Neutral PMS2 P54278 T832P 832 T P 0.1 Neutral PMS2 P54278 T832Q 832 T Q 0.018 Neutral PMS2 P54278 T832R 832 T R 0.264 Neutral PMS2 P54278 T832S 832 T S 0 Neutral PMS2 P54278 T832V 832 T V 0.018 Neutral PMS2 P54278 T832W 832 T W 0.456 Neutral PMS2 P54278 T832Y 832 T Y 0.434 Neutral PMS2 P54278 H833A 833 H A 0.114 Neutral PMS2 P54278 H833C 833 H C 0.076 Neutral PMS2 P54278 H833D 833 H D 0.06 Neutral PMS2 P54278 H833E 833 H E 0.096 Neutral PMS2 P54278 H833F 833 H F 0.358 Neutral PMS2 P54278 H833G 833 H G 0.162 Neutral PMS2 P54278 H833I 833 H I 0.414 Neutral PMS2 P54278 H833K 833 H K 0.19 Neutral PMS2 P54278 H833L 833 H L 0.368 Neutral PMS2 P54278 H833M 833 H M 0.196 Neutral PMS2 P54278 H833N 833 H N 0.064 Neutral PMS2 P54278 H833P 833 H P 0.448 Neutral PMS2 P54278 H833Q 833 H Q 0.132 Neutral PMS2 P54278 H833R 833 H R 0.08 Neutral PMS2 P54278 H833S 833 H S 0.218 Neutral PMS2 P54278 H833T 833 H T 0.238 Neutral PMS2 P54278 H833V 833 H V 0.228 Neutral PMS2 P54278 H833W 833 H W 0.658 Pathogenic PMS2 P54278 H833Y 833 H Y 0.424 Neutral PMS2 P54278 M834A 834 M A 0.112 Neutral PMS2 P54278 M834C 834 M C 0.076 Neutral PMS2 P54278 M834D 834 M D 0.236 Neutral PMS2 P54278 M834E 834 M E 0.11 Neutral PMS2 P54278 M834F 834 M F 0.358 Neutral PMS2 P54278 M834G 834 M G 0.168 Neutral PMS2 P54278 M834H 834 M H 0.1 Neutral PMS2 P54278 M834I 834 M I 0.194 Neutral PMS2 P54278 M834K 834 M K 0.166 Neutral PMS2 P54278 M834L 834 M L 0.094 Neutral PMS2 P54278 M834N 834 M N 0.276 Neutral PMS2 P54278 M834P 834 M P 0.424 Neutral PMS2 P54278 M834Q 834 M Q 0.102 Neutral PMS2 P54278 M834R 834 M R 0.274 Neutral PMS2 P54278 M834S 834 M S 0.232 Neutral PMS2 P54278 M834T 834 M T 0.216 Neutral PMS2 P54278 M834V 834 M V 0.202 Neutral PMS2 P54278 M834W 834 M W 0.682 Pathogenic PMS2 P54278 M834Y 834 M Y 0.588 Pathogenic PMS2 P54278 G835A 835 G A 0.166 Neutral PMS2 P54278 G835C 835 G C 0.37 Neutral PMS2 P54278 G835D 835 G D 0.434 Neutral PMS2 P54278 G835E 835 G E 0.574 Pathogenic PMS2 P54278 G835F 835 G F 0.772 Pathogenic PMS2 P54278 G835H 835 G H 0.716 Pathogenic PMS2 P54278 G835I 835 G I 0.688 Pathogenic PMS2 P54278 G835K 835 G K 0.698 Pathogenic PMS2 P54278 G835L 835 G L 0.688 Pathogenic PMS2 P54278 G835M 835 G M 0.706 Pathogenic PMS2 P54278 G835N 835 G N 0.428 Neutral PMS2 P54278 G835P 835 G P 0.646 Pathogenic PMS2 P54278 G835Q 835 G Q 0.46 Neutral PMS2 P54278 G835R 835 G R 0.764 Pathogenic PMS2 P54278 G835S 835 G S 0.31 Neutral PMS2 P54278 G835T 835 G T 0.478 Neutral PMS2 P54278 G835V 835 G V 0.668 Pathogenic PMS2 P54278 G835W 835 G W 0.77 Pathogenic PMS2 P54278 G835Y 835 G Y 0.754 Pathogenic PMS2 P54278 E836A 836 E A 0.172 Neutral PMS2 P54278 E836C 836 E C 0.118 Neutral PMS2 P54278 E836D 836 E D 0.13 Neutral PMS2 P54278 E836F 836 E F 0.422 Neutral PMS2 P54278 E836G 836 E G 0.078 Neutral PMS2 P54278 E836H 836 E H 0.17 Neutral PMS2 P54278 E836I 836 E I 0.444 Neutral PMS2 P54278 E836K 836 E K 0.276 Neutral PMS2 P54278 E836L 836 E L 0.442 Neutral PMS2 P54278 E836M 836 E M 0.282 Neutral PMS2 P54278 E836N 836 E N 0.086 Neutral PMS2 P54278 E836P 836 E P 0.454 Neutral PMS2 P54278 E836Q 836 E Q 0.02 Neutral PMS2 P54278 E836R 836 E R 0.118 Neutral PMS2 P54278 E836S 836 E S 0.22 Neutral PMS2 P54278 E836T 836 E T 0.246 Neutral PMS2 P54278 E836V 836 E V 0.392 Neutral PMS2 P54278 E836W 836 E W 0.696 Pathogenic PMS2 P54278 E836Y 836 E Y 0.58 Pathogenic PMS2 P54278 M837A 837 M A 0.076 Neutral PMS2 P54278 M837C 837 M C 0.042 Neutral PMS2 P54278 M837D 837 M D 0.166 Neutral PMS2 P54278 M837E 837 M E 0.066 Neutral PMS2 P54278 M837F 837 M F 0.23 Neutral PMS2 P54278 M837G 837 M G 0.122 Neutral PMS2 P54278 M837H 837 M H 0.058 Neutral PMS2 P54278 M837I 837 M I 0.004 Neutral PMS2 P54278 M837K 837 M K 0.086 Neutral PMS2 P54278 M837L 837 M L 0.066 Neutral PMS2 P54278 M837N 837 M N 0.198 Neutral PMS2 P54278 M837P 837 M P 0.284 Neutral PMS2 P54278 M837Q 837 M Q 0.068 Neutral PMS2 P54278 M837R 837 M R 0.186 Neutral PMS2 P54278 M837S 837 M S 0.164 Neutral PMS2 P54278 M837T 837 M T 0.146 Neutral PMS2 P54278 M837V 837 M V 0.126 Neutral PMS2 P54278 M837W 837 M W 0.492 Neutral PMS2 P54278 M837Y 837 M Y 0.404 Neutral PMS2 P54278 D838A 838 D A 0.084 Neutral PMS2 P54278 D838C 838 D C 0.156 Neutral PMS2 P54278 D838E 838 D E 0.01 Neutral PMS2 P54278 D838F 838 D F 0.462 Neutral PMS2 P54278 D838G 838 D G 0.142 Neutral PMS2 P54278 D838H 838 D H 0.098 Neutral PMS2 P54278 D838I 838 D I 0.3 Neutral PMS2 P54278 D838K 838 D K 0.192 Neutral PMS2 P54278 D838L 838 D L 0.294 Neutral PMS2 P54278 D838M 838 D M 0.216 Neutral PMS2 P54278 D838N 838 D N 0.06 Neutral PMS2 P54278 D838P 838 D P 0.318 Neutral PMS2 P54278 D838Q 838 D Q 0.116 Neutral PMS2 P54278 D838R 838 D R 0.224 Neutral PMS2 P54278 D838S 838 D S 0.15 Neutral PMS2 P54278 D838T 838 D T 0.12 Neutral PMS2 P54278 D838V 838 D V 0.296 Neutral PMS2 P54278 D838W 838 D W 0.528 Pathogenic PMS2 P54278 D838Y 838 D Y 0.498 Neutral PMS2 P54278 H839A 839 H A 0.086 Neutral PMS2 P54278 H839C 839 H C 0.062 Neutral PMS2 P54278 H839D 839 H D 0.048 Neutral PMS2 P54278 H839E 839 H E 0.082 Neutral PMS2 P54278 H839F 839 H F 0.272 Neutral PMS2 P54278 H839G 839 H G 0.134 Neutral PMS2 P54278 H839I 839 H I 0.328 Neutral PMS2 P54278 H839K 839 H K 0.168 Neutral PMS2 P54278 H839L 839 H L 0.286 Neutral PMS2 P54278 H839M 839 H M 0.136 Neutral PMS2 P54278 H839N 839 H N 0.068 Neutral PMS2 P54278 H839P 839 H P 0.356 Neutral PMS2 P54278 H839Q 839 H Q 0.008 Neutral PMS2 P54278 H839R 839 H R 0.068 Neutral PMS2 P54278 H839S 839 H S 0.18 Neutral PMS2 P54278 H839T 839 H T 0.188 Neutral PMS2 P54278 H839V 839 H V 0.176 Neutral PMS2 P54278 H839W 839 H W 0.568 Pathogenic PMS2 P54278 H839Y 839 H Y 0.334 Neutral PMS2 P54278 T84A 84 T A 0.002 Neutral PMS2 P54278 T84C 84 T C 0.064 Neutral PMS2 P54278 T84D 84 T D 0.072 Neutral PMS2 P54278 T84E 84 T E 0.096 Neutral PMS2 P54278 T84F 84 T F 0.384 Neutral PMS2 P54278 T84G 84 T G 0.092 Neutral PMS2 P54278 T84H 84 T H 0.174 Neutral PMS2 P54278 T84I 84 T I 0.15 Neutral PMS2 P54278 T84K 84 T K 0.11 Neutral PMS2 P54278 T84L 84 T L 0.162 Neutral PMS2 P54278 T84M 84 T M 0.268 Neutral PMS2 P54278 T84N 84 T N 0.082 Neutral PMS2 P54278 T84P 84 T P 0.182 Neutral PMS2 P54278 T84Q 84 T Q 0.104 Neutral PMS2 P54278 T84R 84 T R 0.438 Neutral PMS2 P54278 T84S 84 T S 0.002 Neutral PMS2 P54278 T84V 84 T V 0.33 Neutral PMS2 P54278 T84W 84 T W 0.706 Pathogenic PMS2 P54278 T84Y 84 T Y 0.668 Pathogenic PMS2 P54278 P840A 840 P A 0.258 Neutral PMS2 P54278 P840C 840 P C 0.242 Neutral PMS2 P54278 P840D 840 P D 0.136 Neutral PMS2 P54278 P840E 840 P E 0.37 Neutral PMS2 P54278 P840F 840 P F 0.524 Pathogenic PMS2 P54278 P840G 840 P G 0.138 Neutral PMS2 P54278 P840H 840 P H 0.484 Neutral PMS2 P54278 P840I 840 P I 0.22 Neutral PMS2 P54278 P840K 840 P K 0.364 Neutral PMS2 P54278 P840L 840 P L 0.18 Neutral PMS2 P54278 P840M 840 P M 0.388 Neutral PMS2 P54278 P840N 840 P N 0.106 Neutral PMS2 P54278 P840Q 840 P Q 0.372 Neutral PMS2 P54278 P840R 840 P R 0.538 Pathogenic PMS2 P54278 P840S 840 P S 0.172 Neutral PMS2 P54278 P840T 840 P T 0.196 Neutral PMS2 P54278 P840V 840 P V 0.224 Neutral PMS2 P54278 P840W 840 P W 0.62 Pathogenic PMS2 P54278 P840Y 840 P Y 0.552 Pathogenic PMS2 P54278 W841A 841 W A 0.132 Neutral PMS2 P54278 W841C 841 W C 0.132 Neutral PMS2 P54278 W841D 841 W D 0.198 Neutral PMS2 P54278 W841E 841 W E 0.252 Neutral PMS2 P54278 W841F 841 W F 0.098 Neutral PMS2 P54278 W841G 841 W G 0.144 Neutral PMS2 P54278 W841H 841 W H 0.134 Neutral PMS2 P54278 W841I 841 W I 0.134 Neutral PMS2 P54278 W841K 841 W K 0.25 Neutral PMS2 P54278 W841L 841 W L 0.098 Neutral PMS2 P54278 W841M 841 W M 0.128 Neutral PMS2 P54278 W841N 841 W N 0.144 Neutral PMS2 P54278 W841P 841 W P 0.156 Neutral PMS2 P54278 W841Q 841 W Q 0.144 Neutral PMS2 P54278 W841R 841 W R 0.24 Neutral PMS2 P54278 W841S 841 W S 0.148 Neutral PMS2 P54278 W841T 841 W T 0.132 Neutral PMS2 P54278 W841V 841 W V 0.162 Neutral PMS2 P54278 W841Y 841 W Y 0.21 Neutral PMS2 P54278 N842A 842 N A 0.18 Neutral PMS2 P54278 N842C 842 N C 0.25 Neutral PMS2 P54278 N842D 842 N D 0.15 Neutral PMS2 P54278 N842E 842 N E 0.166 Neutral PMS2 P54278 N842F 842 N F 0.594 Pathogenic PMS2 P54278 N842G 842 N G 0.238 Neutral PMS2 P54278 N842H 842 N H 0.374 Neutral PMS2 P54278 N842I 842 N I 0.44 Neutral PMS2 P54278 N842K 842 N K 0.372 Neutral PMS2 P54278 N842L 842 N L 0.444 Neutral PMS2 P54278 N842M 842 N M 0.376 Neutral PMS2 P54278 N842P 842 N P 0.4 Neutral PMS2 P54278 N842Q 842 N Q 0.192 Neutral PMS2 P54278 N842R 842 N R 0.36 Neutral PMS2 P54278 N842S 842 N S 0.214 Neutral PMS2 P54278 N842T 842 N T 0.192 Neutral PMS2 P54278 N842V 842 N V 0.454 Neutral PMS2 P54278 N842W 842 N W 0.724 Pathogenic PMS2 P54278 N842Y 842 N Y 0.678 Pathogenic PMS2 P54278 C843A 843 C A 0.136 Neutral PMS2 P54278 C843D 843 C D 0.118 Neutral PMS2 P54278 C843E 843 C E 0.22 Neutral PMS2 P54278 C843F 843 C F 0.666 Pathogenic PMS2 P54278 C843G 843 C G 0.238 Neutral PMS2 P54278 C843H 843 C H 0.372 Neutral PMS2 P54278 C843I 843 C I 0.436 Neutral PMS2 P54278 C843K 843 C K 0.328 Neutral PMS2 P54278 C843L 843 C L 0.402 Neutral PMS2 P54278 C843M 843 C M 0.25 Neutral PMS2 P54278 C843N 843 C N 0.072 Neutral PMS2 P54278 C843P 843 C P 0.438 Neutral PMS2 P54278 C843Q 843 C Q 0.224 Neutral PMS2 P54278 C843R 843 C R 0.478 Neutral PMS2 P54278 C843S 843 C S 0.192 Neutral PMS2 P54278 C843T 843 C T 0.178 Neutral PMS2 P54278 C843V 843 C V 0.342 Neutral PMS2 P54278 C843W 843 C W 0.74 Pathogenic PMS2 P54278 C843Y 843 C Y 0.708 Pathogenic PMS2 P54278 P844A 844 P A 0.258 Neutral PMS2 P54278 P844C 844 P C 0.242 Neutral PMS2 P54278 P844D 844 P D 0.136 Neutral PMS2 P54278 P844E 844 P E 0.37 Neutral PMS2 P54278 P844F 844 P F 0.524 Pathogenic PMS2 P54278 P844G 844 P G 0.138 Neutral PMS2 P54278 P844H 844 P H 0.484 Neutral PMS2 P54278 P844I 844 P I 0.22 Neutral PMS2 P54278 P844K 844 P K 0.364 Neutral PMS2 P54278 P844L 844 P L 0.18 Neutral PMS2 P54278 P844M 844 P M 0.388 Neutral PMS2 P54278 P844N 844 P N 0.106 Neutral PMS2 P54278 P844Q 844 P Q 0.372 Neutral PMS2 P54278 P844R 844 P R 0.538 Pathogenic PMS2 P54278 P844S 844 P S 0.172 Neutral PMS2 P54278 P844T 844 P T 0.196 Neutral PMS2 P54278 P844V 844 P V 0.224 Neutral PMS2 P54278 P844W 844 P W 0.62 Pathogenic PMS2 P54278 P844Y 844 P Y 0.552 Pathogenic PMS2 P54278 H845A 845 H A 0.114 Neutral PMS2 P54278 H845C 845 H C 0.076 Neutral PMS2 P54278 H845D 845 H D 0.06 Neutral PMS2 P54278 H845E 845 H E 0.096 Neutral PMS2 P54278 H845F 845 H F 0.358 Neutral PMS2 P54278 H845G 845 H G 0.162 Neutral PMS2 P54278 H845I 845 H I 0.414 Neutral PMS2 P54278 H845K 845 H K 0.19 Neutral PMS2 P54278 H845L 845 H L 0.368 Neutral PMS2 P54278 H845M 845 H M 0.196 Neutral PMS2 P54278 H845N 845 H N 0.088 Neutral PMS2 P54278 H845P 845 H P 0.448 Neutral PMS2 P54278 H845Q 845 H Q 0.132 Neutral PMS2 P54278 H845R 845 H R 0.08 Neutral PMS2 P54278 H845S 845 H S 0.218 Neutral PMS2 P54278 H845T 845 H T 0.238 Neutral PMS2 P54278 H845V 845 H V 0.228 Neutral PMS2 P54278 H845W 845 H W 0.658 Pathogenic PMS2 P54278 H845Y 845 H Y 0.424 Neutral PMS2 P54278 G846A 846 G A 0.166 Neutral PMS2 P54278 G846C 846 G C 0.37 Neutral PMS2 P54278 G846D 846 G D 0.434 Neutral PMS2 P54278 G846E 846 G E 0.574 Pathogenic PMS2 P54278 G846F 846 G F 0.772 Pathogenic PMS2 P54278 G846H 846 G H 0.716 Pathogenic PMS2 P54278 G846I 846 G I 0.688 Pathogenic PMS2 P54278 G846K 846 G K 0.698 Pathogenic PMS2 P54278 G846L 846 G L 0.688 Pathogenic PMS2 P54278 G846M 846 G M 0.706 Pathogenic PMS2 P54278 G846N 846 G N 0.428 Neutral PMS2 P54278 G846P 846 G P 0.646 Pathogenic PMS2 P54278 G846Q 846 G Q 0.46 Neutral PMS2 P54278 G846R 846 G R 0.764 Pathogenic PMS2 P54278 G846S 846 G S 0.296 Neutral PMS2 P54278 G846T 846 G T 0.478 Neutral PMS2 P54278 G846V 846 G V 0.668 Pathogenic PMS2 P54278 G846W 846 G W 0.77 Pathogenic PMS2 P54278 G846Y 846 G Y 0.754 Pathogenic PMS2 P54278 R847A 847 R A 0.146 Neutral PMS2 P54278 R847C 847 R C 0.246 Neutral PMS2 P54278 R847D 847 R D 0.262 Neutral PMS2 P54278 R847E 847 R E 0.204 Neutral PMS2 P54278 R847F 847 R F 0.456 Neutral PMS2 P54278 R847G 847 R G 0.102 Neutral PMS2 P54278 R847H 847 R H 0.188 Neutral PMS2 P54278 R847I 847 R I 0.478 Neutral PMS2 P54278 R847K 847 R K 0.28 Neutral PMS2 P54278 R847L 847 R L 0.44 Neutral PMS2 P54278 R847M 847 R M 0.258 Neutral PMS2 P54278 R847N 847 R N 0.254 Neutral PMS2 P54278 R847P 847 R P 0.42 Neutral PMS2 P54278 R847Q 847 R Q 0.234 Neutral PMS2 P54278 R847S 847 R S 0.206 Neutral PMS2 P54278 R847T 847 R T 0.212 Neutral PMS2 P54278 R847V 847 R V 0.388 Neutral PMS2 P54278 R847W 847 R W 0.628 Pathogenic PMS2 P54278 R847Y 847 R Y 0.456 Neutral PMS2 P54278 P848A 848 P A 0.258 Neutral PMS2 P54278 P848C 848 P C 0.242 Neutral PMS2 P54278 P848D 848 P D 0.136 Neutral PMS2 P54278 P848E 848 P E 0.37 Neutral PMS2 P54278 P848F 848 P F 0.524 Pathogenic PMS2 P54278 P848G 848 P G 0.138 Neutral PMS2 P54278 P848H 848 P H 0.484 Neutral PMS2 P54278 P848I 848 P I 0.22 Neutral PMS2 P54278 P848K 848 P K 0.364 Neutral PMS2 P54278 P848L 848 P L 0.18 Neutral PMS2 P54278 P848M 848 P M 0.388 Neutral PMS2 P54278 P848N 848 P N 0.106 Neutral PMS2 P54278 P848Q 848 P Q 0.372 Neutral PMS2 P54278 P848R 848 P R 0.538 Pathogenic PMS2 P54278 P848S 848 P S 0.172 Neutral PMS2 P54278 P848T 848 P T 0.196 Neutral PMS2 P54278 P848V 848 P V 0.224 Neutral PMS2 P54278 P848W 848 P W 0.62 Pathogenic PMS2 P54278 P848Y 848 P Y 0.552 Pathogenic PMS2 P54278 T849A 849 T A 0.132 Neutral PMS2 P54278 T849C 849 T C 0.12 Neutral PMS2 P54278 T849D 849 T D 0.116 Neutral PMS2 P54278 T849E 849 T E 0.178 Neutral PMS2 P54278 T849F 849 T F 0.428 Neutral PMS2 P54278 T849G 849 T G 0.098 Neutral PMS2 P54278 T849H 849 T H 0.222 Neutral PMS2 P54278 T849I 849 T I 0.164 Neutral PMS2 P54278 T849K 849 T K 0.154 Neutral PMS2 P54278 T849L 849 T L 0.176 Neutral PMS2 P54278 T849M 849 T M 0.284 Neutral PMS2 P54278 T849N 849 T N 0.086 Neutral PMS2 P54278 T849P 849 T P 0.23 Neutral PMS2 P54278 T849Q 849 T Q 0.11 Neutral PMS2 P54278 T849R 849 T R 0.446 Neutral PMS2 P54278 T849S 849 T S 0.092 Neutral PMS2 P54278 T849V 849 T V 0.346 Neutral PMS2 P54278 T849W 849 T W 0.72 Pathogenic PMS2 P54278 T849Y 849 T Y 0.68 Pathogenic PMS2 P54278 L85A 85 L A 0.04 Neutral PMS2 P54278 L85C 85 L C 0.166 Neutral PMS2 P54278 L85D 85 L D 0.676 Pathogenic PMS2 P54278 L85E 85 L E 0.63 Pathogenic PMS2 P54278 L85F 85 L F 0.796 Pathogenic PMS2 P54278 L85G 85 L G 0.586 Pathogenic PMS2 P54278 L85H 85 L H 0.424 Neutral PMS2 P54278 L85I 85 L I 0.226 Neutral PMS2 P54278 L85K 85 L K 0.042 Neutral PMS2 P54278 L85M 85 L M 0.052 Neutral PMS2 P54278 L85N 85 L N 0.622 Pathogenic PMS2 P54278 L85P 85 L P 0.794 Pathogenic PMS2 P54278 L85Q 85 L Q 0.192 Neutral PMS2 P54278 L85R 85 L R 0.746 Pathogenic PMS2 P54278 L85S 85 L S 0.402 Neutral PMS2 P54278 L85T 85 L T 0.366 Neutral PMS2 P54278 L85V 85 L V 0.426 Neutral PMS2 P54278 L85W 85 L W 0.848 Pathogenic PMS2 P54278 L85Y 85 L Y 0.84 Pathogenic PMS2 P54278 M850A 850 M A 0.108 Neutral PMS2 P54278 M850C 850 M C 0.068 Neutral PMS2 P54278 M850D 850 M D 0.228 Neutral PMS2 P54278 M850E 850 M E 0.104 Neutral PMS2 P54278 M850F 850 M F 0.344 Neutral PMS2 P54278 M850G 850 M G 0.162 Neutral PMS2 P54278 M850H 850 M H 0.096 Neutral PMS2 P54278 M850I 850 M I 0.09 Neutral PMS2 P54278 M850K 850 M K 0.156 Neutral PMS2 P54278 M850L 850 M L 0.118 Neutral PMS2 P54278 M850N 850 M N 0.268 Neutral PMS2 P54278 M850P 850 M P 0.408 Neutral PMS2 P54278 M850Q 850 M Q 0.098 Neutral PMS2 P54278 M850R 850 M R 0.268 Neutral PMS2 P54278 M850S 850 M S 0.222 Neutral PMS2 P54278 M850T 850 M T 0.206 Neutral PMS2 P54278 M850V 850 M V 0.202 Neutral PMS2 P54278 M850W 850 M W 0.668 Pathogenic PMS2 P54278 M850Y 850 M Y 0.574 Pathogenic PMS2 P54278 R851A 851 R A 0.146 Neutral PMS2 P54278 R851C 851 R C 0.246 Neutral PMS2 P54278 R851D 851 R D 0.262 Neutral PMS2 P54278 R851E 851 R E 0.204 Neutral PMS2 P54278 R851F 851 R F 0.456 Neutral PMS2 P54278 R851G 851 R G 0.102 Neutral PMS2 P54278 R851H 851 R H 0.188 Neutral PMS2 P54278 R851I 851 R I 0.478 Neutral PMS2 P54278 R851K 851 R K 0.28 Neutral PMS2 P54278 R851L 851 R L 0.44 Neutral PMS2 P54278 R851M 851 R M 0.258 Neutral PMS2 P54278 R851N 851 R N 0.254 Neutral PMS2 P54278 R851P 851 R P 0.42 Neutral PMS2 P54278 R851Q 851 R Q 0.234 Neutral PMS2 P54278 R851S 851 R S 0.206 Neutral PMS2 P54278 R851T 851 R T 0.212 Neutral PMS2 P54278 R851V 851 R V 0.388 Neutral PMS2 P54278 R851W 851 R W 0.628 Pathogenic PMS2 P54278 R851Y 851 R Y 0.456 Neutral PMS2 P54278 H852A 852 H A 0.114 Neutral PMS2 P54278 H852C 852 H C 0.076 Neutral PMS2 P54278 H852D 852 H D 0.06 Neutral PMS2 P54278 H852E 852 H E 0.096 Neutral PMS2 P54278 H852F 852 H F 0.358 Neutral PMS2 P54278 H852G 852 H G 0.162 Neutral PMS2 P54278 H852I 852 H I 0.414 Neutral PMS2 P54278 H852K 852 H K 0.19 Neutral PMS2 P54278 H852L 852 H L 0.368 Neutral PMS2 P54278 H852M 852 H M 0.196 Neutral PMS2 P54278 H852N 852 H N 0.088 Neutral PMS2 P54278 H852P 852 H P 0.448 Neutral PMS2 P54278 H852Q 852 H Q 0.132 Neutral PMS2 P54278 H852R 852 H R 0.08 Neutral PMS2 P54278 H852S 852 H S 0.218 Neutral PMS2 P54278 H852T 852 H T 0.238 Neutral PMS2 P54278 H852V 852 H V 0.228 Neutral PMS2 P54278 H852W 852 H W 0.658 Pathogenic PMS2 P54278 H852Y 852 H Y 0.424 Neutral PMS2 P54278 I853A 853 I A 0.072 Neutral PMS2 P54278 I853C 853 I C 0.092 Neutral PMS2 P54278 I853D 853 I D 0.15 Neutral PMS2 P54278 I853E 853 I E 0.144 Neutral PMS2 P54278 I853F 853 I F 0.25 Neutral PMS2 P54278 I853G 853 I G 0.212 Neutral PMS2 P54278 I853H 853 I H 0.088 Neutral PMS2 P54278 I853K 853 I K 0.162 Neutral PMS2 P54278 I853L 853 I L 0 Neutral PMS2 P54278 I853M 853 I M 0.17 Neutral PMS2 P54278 I853N 853 I N 0.186 Neutral PMS2 P54278 I853P 853 I P 0.186 Neutral PMS2 P54278 I853Q 853 I Q 0.188 Neutral PMS2 P54278 I853R 853 I R 0.332 Neutral PMS2 P54278 I853S 853 I S 0.162 Neutral PMS2 P54278 I853T 853 I T 0.114 Neutral PMS2 P54278 I853V 853 I V 0.022 Neutral PMS2 P54278 I853W 853 I W 0.408 Neutral PMS2 P54278 I853Y 853 I Y 0.362 Neutral PMS2 P54278 A854C 854 A C 0.24 Neutral PMS2 P54278 A854D 854 A D 0.346 Neutral PMS2 P54278 A854E 854 A E 0.386 Neutral PMS2 P54278 A854F 854 A F 0.572 Pathogenic PMS2 P54278 A854G 854 A G 0.136 Neutral PMS2 P54278 A854H 854 A H 0.384 Neutral PMS2 P54278 A854I 854 A I 0.402 Neutral PMS2 P54278 A854K 854 A K 0.45 Neutral PMS2 P54278 A854L 854 A L 0.514 Pathogenic PMS2 P54278 A854M 854 A M 0.372 Neutral PMS2 P54278 A854N 854 A N 0.354 Neutral PMS2 P54278 A854P 854 A P 0.34 Neutral PMS2 P54278 A854Q 854 A Q 0.38 Neutral PMS2 P54278 A854R 854 A R 0.45 Neutral PMS2 P54278 A854S 854 A S 0.116 Neutral PMS2 P54278 A854T 854 A T 0.218 Neutral PMS2 P54278 A854V 854 A V 0.056 Neutral PMS2 P54278 A854W 854 A W 0.606 Pathogenic PMS2 P54278 A854Y 854 A Y 0.606 Pathogenic PMS2 P54278 N855A 855 N A 0.142 Neutral PMS2 P54278 N855C 855 N C 0.188 Neutral PMS2 P54278 N855D 855 N D 0.112 Neutral PMS2 P54278 N855E 855 N E 0.128 Neutral PMS2 P54278 N855F 855 N F 0.498 Neutral PMS2 P54278 N855G 855 N G 0.19 Neutral PMS2 P54278 N855H 855 N H 0.294 Neutral PMS2 P54278 N855I 855 N I 0.356 Neutral PMS2 P54278 N855K 855 N K 0.29 Neutral PMS2 P54278 N855L 855 N L 0.356 Neutral PMS2 P54278 N855M 855 N M 0.296 Neutral PMS2 P54278 N855P 855 N P 0.318 Neutral PMS2 P54278 N855Q 855 N Q 0.144 Neutral PMS2 P54278 N855R 855 N R 0.306 Neutral PMS2 P54278 N855S 855 N S 0.004 Neutral PMS2 P54278 N855T 855 N T 0.144 Neutral PMS2 P54278 N855V 855 N V 0.366 Neutral PMS2 P54278 N855W 855 N W 0.63 Pathogenic PMS2 P54278 N855Y 855 N Y 0.586 Pathogenic PMS2 P54278 L856A 856 L A 0.134 Neutral PMS2 P54278 L856C 856 L C 0.138 Neutral PMS2 P54278 L856D 856 L D 0.254 Neutral PMS2 P54278 L856E 856 L E 0.236 Neutral PMS2 P54278 L856F 856 L F 0.378 Neutral PMS2 P54278 L856G 856 L G 0.268 Neutral PMS2 P54278 L856H 856 L H 0.13 Neutral PMS2 P54278 L856I 856 L I 0.068 Neutral PMS2 P54278 L856K 856 L K 0.186 Neutral PMS2 P54278 L856M 856 L M 0.196 Neutral PMS2 P54278 L856N 856 L N 0.246 Neutral PMS2 P54278 L856P 856 L P 0.348 Neutral PMS2 P54278 L856Q 856 L Q 0.108 Neutral PMS2 P54278 L856R 856 L R 0.508 Pathogenic PMS2 P54278 L856S 856 L S 0.202 Neutral PMS2 P54278 L856T 856 L T 0.182 Neutral PMS2 P54278 L856V 856 L V 0.188 Neutral PMS2 P54278 L856W 856 L W 0.54 Pathogenic PMS2 P54278 L856Y 856 L Y 0.502 Pathogenic PMS2 P54278 G857A 857 G A 0.012 Neutral 1 PMS2 P54278 G857C 857 G C 0.182 Neutral PMS2 P54278 G857D 857 G D 0.156 Neutral PMS2 P54278 G857E 857 G E 0.21 Neutral PMS2 P54278 G857F 857 G F 0.558 Pathogenic PMS2 P54278 G857H 857 G H 0.502 Pathogenic PMS2 P54278 G857I 857 G I 0.47 Neutral PMS2 P54278 G857K 857 G K 0.424 Neutral PMS2 P54278 G857L 857 G L 0.47 Neutral PMS2 P54278 G857M 857 G M 0.49 Neutral PMS2 P54278 G857N 857 G N 0.192 Neutral PMS2 P54278 G857P 857 G P 0.438 Neutral PMS2 P54278 G857Q 857 G Q 0.31 Neutral PMS2 P54278 G857R 857 G R 0.542 Pathogenic PMS2 P54278 G857S 857 G S 0.206 Neutral PMS2 P54278 G857T 857 G T 0.318 Neutral PMS2 P54278 G857V 857 G V 0.446 Neutral PMS2 P54278 G857W 857 G W 0.556 Pathogenic PMS2 P54278 G857Y 857 G Y 0.552 Pathogenic PMS2 P54278 V858A 858 V A 0.022 Neutral PMS2 P54278 V858C 858 V C 0.058 Neutral PMS2 P54278 V858D 858 V D 0.126 Neutral PMS2 P54278 V858E 858 V E 0.2 Neutral PMS2 P54278 V858F 858 V F 0.15 Neutral PMS2 P54278 V858G 858 V G 0.196 Neutral PMS2 P54278 V858H 858 V H 0.112 Neutral PMS2 P54278 V858I 858 V I 0.002 Neutral PMS2 P54278 V858K 858 V K 0.158 Neutral PMS2 P54278 V858L 858 V L 0 Neutral PMS2 P54278 V858M 858 V M 0.012 Neutral PMS2 P54278 V858N 858 V N 0.138 Neutral PMS2 P54278 V858P 858 V P 0.19 Neutral PMS2 P54278 V858Q 858 V Q 0.216 Neutral PMS2 P54278 V858R 858 V R 0.274 Neutral PMS2 P54278 V858S 858 V S 0.09 Neutral PMS2 P54278 V858T 858 V T 0.058 Neutral PMS2 P54278 V858W 858 V W 0.344 Neutral PMS2 P54278 V858Y 858 V Y 0.256 Neutral PMS2 P54278 I859A 859 I A 0.072 Neutral PMS2 P54278 I859C 859 I C 0.092 Neutral PMS2 P54278 I859D 859 I D 0.15 Neutral PMS2 P54278 I859E 859 I E 0.144 Neutral PMS2 P54278 I859F 859 I F 0.258 Neutral PMS2 P54278 I859G 859 I G 0.212 Neutral PMS2 P54278 I859H 859 I H 0.088 Neutral PMS2 P54278 I859K 859 I K 0.162 Neutral PMS2 P54278 I859L 859 I L 0 Neutral PMS2 P54278 I859M 859 I M 0.116 Neutral PMS2 P54278 I859N 859 I N 0.186 Neutral PMS2 P54278 I859P 859 I P 0.186 Neutral PMS2 P54278 I859Q 859 I Q 0.188 Neutral PMS2 P54278 I859R 859 I R 0.338 Neutral PMS2 P54278 I859S 859 I S 0.162 Neutral PMS2 P54278 I859T 859 I T 0.192 Neutral PMS2 P54278 I859V 859 I V 0 Neutral PMS2 P54278 I859W 859 I W 0.414 Neutral PMS2 P54278 I859Y 859 I Y 0.37 Neutral PMS2 P54278 K86A 86 K A 0.138 Neutral PMS2 P54278 K86C 86 K C 0.398 Neutral PMS2 P54278 K86D 86 K D 0.548 Pathogenic PMS2 P54278 K86E 86 K E 0.63 Pathogenic PMS2 P54278 K86F 86 K F 0.824 Pathogenic PMS2 P54278 K86G 86 K G 0.32 Neutral PMS2 P54278 K86H 86 K H 0.632 Pathogenic PMS2 P54278 K86I 86 K I 0.936 Pathogenic PMS2 P54278 K86L 86 K L 0.914 Pathogenic PMS2 P54278 K86M 86 K M 0.438 Neutral PMS2 P54278 K86N 86 K N 0.61 Pathogenic PMS2 P54278 K86P 86 K P 0.336 Neutral PMS2 P54278 K86Q 86 K Q 0.254 Neutral PMS2 P54278 K86R 86 K R 0.162 Neutral PMS2 P54278 K86S 86 K S 0.604 Pathogenic PMS2 P54278 K86T 86 K T 0.47 Neutral PMS2 P54278 K86V 86 K V 0.77 Pathogenic PMS2 P54278 K86W 86 K W 0.926 Pathogenic PMS2 P54278 K86Y 86 K Y 0.896 Pathogenic PMS2 P54278 S860A 860 S A 0.032 Neutral PMS2 P54278 S860C 860 S C 0.072 Neutral PMS2 P54278 S860D 860 S D 0.114 Neutral PMS2 P54278 S860E 860 S E 0.328 Neutral PMS2 P54278 S860F 860 S F 0.506 Pathogenic PMS2 P54278 S860G 860 S G 0.112 Neutral PMS2 P54278 S860H 860 S H 0.434 Neutral PMS2 P54278 S860I 860 S I 0.158 Neutral PMS2 P54278 S860K 860 S K 0.362 Neutral PMS2 P54278 S860L 860 S L 0.162 Neutral PMS2 P54278 S860M 860 S M 0.608 Pathogenic PMS2 P54278 S860N 860 S N 0.1 Neutral PMS2 P54278 S860P 860 S P 0.204 Neutral PMS2 P54278 S860Q 860 S Q 0.32 Neutral PMS2 P54278 S860R 860 S R 0.44 Neutral PMS2 P54278 S860T 860 S T 0.138 Neutral PMS2 P54278 S860V 860 S V 0.394 Neutral PMS2 P54278 S860W 860 S W 0.724 Pathogenic PMS2 P54278 S860Y 860 S Y 0.686 Pathogenic PMS2 P54278 Q861A 861 Q A 0.116 Neutral PMS2 P54278 Q861C 861 Q C 0.098 Neutral PMS2 P54278 Q861D 861 Q D 0.096 Neutral PMS2 P54278 Q861E 861 Q E 0.098 Neutral PMS2 P54278 Q861F 861 Q F 0.316 Neutral PMS2 P54278 Q861G 861 Q G 0.126 Neutral PMS2 P54278 Q861H 861 Q H 0.252 Neutral PMS2 P54278 Q861I 861 Q I 0.332 Neutral PMS2 P54278 Q861K 861 Q K 0.25 Neutral PMS2 P54278 Q861L 861 Q L 0.288 Neutral PMS2 P54278 Q861M 861 Q M 0.226 Neutral PMS2 P54278 Q861N 861 Q N 0.104 Neutral PMS2 P54278 Q861P 861 Q P 0.428 Neutral PMS2 P54278 Q861R 861 Q R 0.054 Neutral PMS2 P54278 Q861S 861 Q S 0.19 Neutral PMS2 P54278 Q861T 861 Q T 0.142 Neutral PMS2 P54278 Q861V 861 Q V 0.318 Neutral PMS2 P54278 Q861W 861 Q W 0.53 Pathogenic PMS2 P54278 Q861Y 861 Q Y 0.468 Neutral PMS2 P54278 N862A 862 N A 0.092 Neutral PMS2 P54278 N862C 862 N C 0.148 Neutral PMS2 P54278 N862D 862 N D 0.01 Neutral PMS2 P54278 N862E 862 N E 0.096 Neutral PMS2 P54278 N862F 862 N F 0.34 Neutral PMS2 P54278 N862G 862 N G 0.162 Neutral PMS2 P54278 N862H 862 N H 0.132 Neutral PMS2 P54278 N862I 862 N I 0.266 Neutral PMS2 P54278 N862K 862 N K 0.224 Neutral PMS2 P54278 N862L 862 N L 0.272 Neutral PMS2 P54278 N862M 862 N M 0.22 Neutral PMS2 P54278 N862P 862 N P 0.248 Neutral PMS2 P54278 N862Q 862 N Q 0.114 Neutral PMS2 P54278 N862R 862 N R 0.158 Neutral PMS2 P54278 N862S 862 N S 0 Neutral PMS2 P54278 N862T 862 N T 0.116 Neutral PMS2 P54278 N862V 862 N V 0.28 Neutral PMS2 P54278 N862W 862 N W 0.446 Neutral PMS2 P54278 N862Y 862 N Y 0.402 Neutral PMS2 P54278 H87A 87 H A 0.366 Neutral PMS2 P54278 H87C 87 H C 0.292 Neutral PMS2 P54278 H87D 87 H D 0.266 Neutral PMS2 P54278 H87E 87 H E 0.39 Neutral PMS2 P54278 H87F 87 H F 0.704 Pathogenic PMS2 P54278 H87G 87 H G 0.304 Neutral PMS2 P54278 H87I 87 H I 0.72 Pathogenic PMS2 P54278 H87K 87 H K 0.546 Pathogenic PMS2 P54278 H87L 87 H L 0.66 Pathogenic PMS2 P54278 H87M 87 H M 0.558 Pathogenic PMS2 P54278 H87N 87 H N 0.232 Neutral PMS2 P54278 H87P 87 H P 0.856 Pathogenic PMS2 P54278 H87Q 87 H Q 0.412 Neutral PMS2 P54278 H87R 87 H R 0.438 Neutral PMS2 P54278 H87S 87 H S 0.05 Neutral PMS2 P54278 H87T 87 H T 0.406 Neutral PMS2 P54278 H87V 87 H V 0.454 Neutral PMS2 P54278 H87W 87 H W 0.914 Pathogenic PMS2 P54278 H87Y 87 H Y 0.11 Neutral PMS2 P54278 H88A 88 H A 0.154 Neutral PMS2 P54278 H88C 88 H C 0.126 Neutral PMS2 P54278 H88D 88 H D 0.246 Neutral PMS2 P54278 H88E 88 H E 0.352 Neutral PMS2 P54278 H88F 88 H F 0.23 Neutral PMS2 P54278 H88G 88 H G 0.31 Neutral PMS2 P54278 H88I 88 H I 0.786 Pathogenic PMS2 P54278 H88K 88 H K 0.616 Pathogenic PMS2 P54278 H88L 88 H L 0.672 Pathogenic PMS2 P54278 H88M 88 H M 0.638 Pathogenic PMS2 P54278 H88N 88 H N 0.202 Neutral PMS2 P54278 H88P 88 H P 0.752 Pathogenic PMS2 P54278 H88Q 88 H Q 0.364 Neutral PMS2 P54278 H88R 88 H R 0.4 Neutral PMS2 P54278 H88S 88 H S 0.074 Neutral PMS2 P54278 H88T 88 H T 0.432 Neutral PMS2 P54278 H88V 88 H V 0.554 Pathogenic PMS2 P54278 H88W 88 H W 0.912 Pathogenic PMS2 P54278 H88Y 88 H Y 0.094 Neutral PMS2 P54278 T89A 89 T A 0.256 Neutral PMS2 P54278 T89C 89 T C 0.806 Pathogenic PMS2 P54278 T89D 89 T D 0.82 Pathogenic PMS2 P54278 T89E 89 T E 0.888 Pathogenic PMS2 P54278 T89F 89 T F 0.906 Pathogenic PMS2 P54278 T89G 89 T G 0.57 Pathogenic PMS2 P54278 T89H 89 T H 0.832 Pathogenic PMS2 P54278 T89I 89 T I 0.868 Pathogenic PMS2 P54278 T89K 89 T K 0.846 Pathogenic PMS2 P54278 T89L 89 T L 0.854 Pathogenic PMS2 P54278 T89M 89 T M 0.944 Pathogenic PMS2 P54278 T89N 89 T N 0.734 Pathogenic PMS2 P54278 T89P 89 T P 0.61 Pathogenic PMS2 P54278 T89Q 89 T Q 0.744 Pathogenic PMS2 P54278 T89R 89 T R 0.952 Pathogenic PMS2 P54278 T89S 89 T S 0.658 Pathogenic PMS2 P54278 T89V 89 T V 0.852 Pathogenic PMS2 P54278 T89W 89 T W 0.98 Pathogenic PMS2 P54278 T89Y 89 T Y 0.98 Pathogenic PMS2 P54278 T9A 9 T A 0.002 Neutral PMS2 P54278 T9C 9 T C 0.034 Neutral PMS2 P54278 T9D 9 T D 0.024 Neutral PMS2 P54278 T9E 9 T E 0.026 Neutral PMS2 P54278 T9F 9 T F 0.236 Neutral PMS2 P54278 T9G 9 T G 0.036 Neutral PMS2 P54278 T9H 9 T H 0.074 Neutral PMS2 P54278 T9I 9 T I 0.042 Neutral PMS2 P54278 T9K 9 T K 0.002 Neutral PMS2 P54278 T9L 9 T L 0.044 Neutral PMS2 P54278 T9M 9 T M 0.06 Neutral PMS2 P54278 T9N 9 T N 0 Neutral PMS2 P54278 T9P 9 T P 0.012 Neutral PMS2 P54278 T9Q 9 T Q 0 Neutral PMS2 P54278 T9R 9 T R 0.2 Neutral PMS2 P54278 T9S 9 T S 0 Neutral PMS2 P54278 T9V 9 T V 0.096 Neutral PMS2 P54278 T9W 9 T W 0.504 Pathogenic PMS2 P54278 T9Y 9 T Y 0.326 Neutral PMS2 P54278 S90A 90 S A 0.164 Neutral PMS2 P54278 S90C 90 S C 0.232 Neutral PMS2 P54278 S90D 90 S D 0.762 Pathogenic PMS2 P54278 S90E 90 S E 0.886 Pathogenic PMS2 P54278 S90F 90 S F 0.97 Pathogenic PMS2 P54278 S90G 90 S G 0.512 Pathogenic PMS2 P54278 S90H 90 S H 0.912 Pathogenic PMS2 P54278 S90I 90 S I 0.82 Pathogenic PMS2 P54278 S90K 90 S K 0.878 Pathogenic PMS2 P54278 S90L 90 S L 0.846 Pathogenic PMS2 P54278 S90M 90 S M 0.99 Pathogenic PMS2 P54278 S90N 90 S N 0.722 Pathogenic PMS2 P54278 S90P 90 S P 0.874 Pathogenic PMS2 P54278 S90Q 90 S Q 0.582 Pathogenic PMS2 P54278 S90R 90 S R 0.918 Pathogenic PMS2 P54278 S90T 90 S T 0.688 Pathogenic PMS2 P54278 S90V 90 S V 0.866 Pathogenic PMS2 P54278 S90W 90 S W 0.94 Pathogenic PMS2 P54278 S90Y 90 S Y 0.938 Pathogenic PMS2 P54278 K91A 91 K A 0.486 Neutral PMS2 P54278 K91C 91 K C 0.404 Neutral PMS2 P54278 K91D 91 K D 0.134 Neutral PMS2 P54278 K91E 91 K E 0.104 Neutral PMS2 P54278 K91F 91 K F 0.88 Pathogenic PMS2 P54278 K91G 91 K G 0.162 Neutral PMS2 P54278 K91H 91 K H 0.666 Pathogenic PMS2 P54278 K91I 91 K I 0.96 Pathogenic PMS2 P54278 K91L 91 K L 0.942 Pathogenic PMS2 P54278 K91M 91 K M 0.448 Neutral PMS2 P54278 K91N 91 K N 0.238 Neutral PMS2 P54278 K91P 91 K P 0.642 Pathogenic PMS2 P54278 K91Q 91 K Q 0.686 Pathogenic PMS2 P54278 K91R 91 K R 0.252 Neutral PMS2 P54278 K91S 91 K S 0.358 Neutral PMS2 P54278 K91T 91 K T 0.278 Neutral PMS2 P54278 K91V 91 K V 0.798 Pathogenic PMS2 P54278 K91W 91 K W 0.966 Pathogenic PMS2 P54278 K91Y 91 K Y 0.944 Pathogenic PMS2 P54278 I92A 92 I A 0.16 Neutral PMS2 P54278 I92C 92 I C 0.406 Neutral PMS2 P54278 I92D 92 I D 0.608 Pathogenic PMS2 P54278 I92E 92 I E 0.59 Pathogenic PMS2 P54278 I92F 92 I F 0.706 Pathogenic PMS2 P54278 I92G 92 I G 0.586 Pathogenic PMS2 P54278 I92H 92 I H 0.468 Neutral PMS2 P54278 I92K 92 I K 0.508 Pathogenic PMS2 P54278 I92L 92 I L 0.14 Neutral PMS2 P54278 I92M 92 I M 0.412 Neutral PMS2 P54278 I92N 92 I N 0.634 Pathogenic PMS2 P54278 I92P 92 I P 0.598 Pathogenic PMS2 P54278 I92Q 92 I Q 0.566 Pathogenic PMS2 P54278 I92R 92 I R 0.828 Pathogenic PMS2 P54278 I92S 92 I S 0.496 Neutral PMS2 P54278 I92T 92 I T 0.076 Neutral PMS2 P54278 I92V 92 I V 0.186 Neutral PMS2 P54278 I92W 92 I W 0.902 Pathogenic PMS2 P54278 I92Y 92 I Y 0.906 Pathogenic PMS2 P54278 Q93A 93 Q A 0.058 Neutral PMS2 P54278 Q93C 93 Q C 0.19 Neutral PMS2 P54278 Q93D 93 Q D 0.13 Neutral PMS2 P54278 Q93E 93 Q E 0.014 Neutral PMS2 P54278 Q93F 93 Q F 0.488 Neutral PMS2 P54278 Q93G 93 Q G 0.282 Neutral PMS2 P54278 Q93H 93 Q H 0.516 Pathogenic PMS2 P54278 Q93I 93 Q I 0.388 Neutral PMS2 P54278 Q93K 93 Q K 0.03 Neutral PMS2 P54278 Q93L 93 Q L 0.564 Pathogenic PMS2 P54278 Q93M 93 Q M 0.452 Neutral PMS2 P54278 Q93N 93 Q N 0.164 Neutral PMS2 P54278 Q93P 93 Q P 0.63 Pathogenic PMS2 P54278 Q93R 93 Q R 0.012 Neutral PMS2 P54278 Q93S 93 Q S 0.06 Neutral PMS2 P54278 Q93T 93 Q T 0.006 Neutral PMS2 P54278 Q93V 93 Q V 0.512 Pathogenic PMS2 P54278 Q93W 93 Q W 0.758 Pathogenic PMS2 P54278 Q93Y 93 Q Y 0.668 Pathogenic PMS2 P54278 E94A 94 E A 0.308 Neutral PMS2 P54278 E94C 94 E C 0.396 Neutral PMS2 P54278 E94D 94 E D 0.024 Neutral PMS2 P54278 E94F 94 E F 0.784 Pathogenic PMS2 P54278 E94G 94 E G 0.148 Neutral PMS2 P54278 E94H 94 E H 0.538 Pathogenic PMS2 P54278 E94I 94 E I 0.838 Pathogenic PMS2 P54278 E94K 94 E K 0.338 Neutral PMS2 P54278 E94L 94 E L 0.812 Pathogenic PMS2 P54278 E94M 94 E M 0.638 Pathogenic PMS2 P54278 E94N 94 E N 0.018 Neutral PMS2 P54278 E94P 94 E P 0.844 Pathogenic PMS2 P54278 E94Q 94 E Q 0.014 Neutral PMS2 P54278 E94R 94 E R 0.148 Neutral PMS2 P54278 E94S 94 E S 0.034 Neutral PMS2 P54278 E94T 94 E T 0.03 Neutral PMS2 P54278 E94V 94 E V 0.798 Pathogenic PMS2 P54278 E94W 94 E W 0.92 Pathogenic PMS2 P54278 E94Y 94 E Y 0.846 Pathogenic PMS2 P54278 F95A 95 F A 0.122 Neutral PMS2 P54278 F95C 95 F C 0.314 Neutral PMS2 P54278 F95D 95 F D 0.458 Neutral PMS2 P54278 F95E 95 F E 0.682 Pathogenic PMS2 P54278 F95G 95 F G 0.368 Neutral PMS2 P54278 F95H 95 F H 0.1 Neutral PMS2 P54278 F95I 95 F I 0.462 Neutral PMS2 P54278 F95K 95 F K 0.084 Neutral PMS2 P54278 F95L 95 F L 0.17 Neutral PMS2 P54278 F95M 95 F M 0.374 Neutral PMS2 P54278 F95N 95 F N 0.474 Neutral PMS2 P54278 F95P 95 F P 0.764 Pathogenic PMS2 P54278 F95Q 95 F Q 0.474 Neutral PMS2 P54278 F95R 95 F R 0.67 Pathogenic PMS2 P54278 F95S 95 F S 0.182 Neutral PMS2 P54278 F95T 95 F T 0.392 Neutral PMS2 P54278 F95V 95 F V 0.47 Neutral PMS2 P54278 F95W 95 F W 0.85 Pathogenic PMS2 P54278 F95Y 95 F Y 0.032 Neutral PMS2 P54278 A96C 96 A C 0.666 Pathogenic PMS2 P54278 A96D 96 A D 0.616 Pathogenic PMS2 P54278 A96E 96 A E 0.544 Pathogenic PMS2 P54278 A96F 96 A F 0.932 Pathogenic PMS2 P54278 A96G 96 A G 0.024 Neutral PMS2 P54278 A96H 96 A H 0.512 Pathogenic PMS2 P54278 A96I 96 A I 0.926 Pathogenic PMS2 P54278 A96K 96 A K 0.86 Pathogenic PMS2 P54278 A96L 96 A L 0.908 Pathogenic PMS2 P54278 A96M 96 A M 0.79 Pathogenic PMS2 P54278 A96N 96 A N 0.546 Pathogenic PMS2 P54278 A96P 96 A P 0.126 Neutral PMS2 P54278 A96Q 96 A Q 0.482 Neutral PMS2 P54278 A96R 96 A R 0.584 Pathogenic PMS2 P54278 A96S 96 A S 0.052 Neutral PMS2 P54278 A96T 96 A T 0.034 Neutral PMS2 P54278 A96V 96 A V 0.122 Neutral PMS2 P54278 A96W 96 A W 0.922 Pathogenic PMS2 P54278 A96Y 96 A Y 0.912 Pathogenic PMS2 P54278 D97A 97 D A 0.558 Pathogenic PMS2 P54278 D97C 97 D C 0.882 Pathogenic PMS2 P54278 D97E 97 D E 0.418 Neutral PMS2 P54278 D97F 97 D F 0.98 Pathogenic PMS2 P54278 D97G 97 D G 0.392 Neutral PMS2 P54278 D97H 97 D H 0.654 Pathogenic PMS2 P54278 D97I 97 D I 0.974 Pathogenic PMS2 P54278 D97K 97 D K 0.912 Pathogenic PMS2 P54278 D97L 97 D L 0.978 Pathogenic PMS2 P54278 D97M 97 D M 0.956 Pathogenic PMS2 P54278 D97N 97 D N 0.384 Neutral PMS2 P54278 D97P 97 D P 0.902 Pathogenic PMS2 P54278 D97Q 97 D Q 0.606 Pathogenic PMS2 P54278 D97R 97 D R 0.958 Pathogenic PMS2 P54278 D97S 97 D S 0.556 Pathogenic PMS2 P54278 D97T 97 D T 0.796 Pathogenic PMS2 P54278 D97V 97 D V 0.996 Pathogenic PMS2 P54278 D97W 97 D W 0.982 Pathogenic PMS2 P54278 D97Y 97 D Y 0.974 Pathogenic PMS2 P54278 L98A 98 L A 0.714 Pathogenic PMS2 P54278 L98C 98 L C 0.822 Pathogenic PMS2 P54278 L98D 98 L D 0.91 Pathogenic PMS2 P54278 L98E 98 L E 0.896 Pathogenic PMS2 P54278 L98F 98 L F 0.656 Pathogenic PMS2 P54278 L98G 98 L G 0.864 Pathogenic PMS2 P54278 L98H 98 L H 0.91 Pathogenic PMS2 P54278 L98I 98 L I 0.396 Neutral PMS2 P54278 L98K 98 L K 0.728 Pathogenic PMS2 P54278 L98M 98 L M 0.47 Neutral PMS2 P54278 L98N 98 L N 0.82 Pathogenic PMS2 P54278 L98P 98 L P 0.992 Pathogenic PMS2 P54278 L98Q 98 L Q 0.776 Pathogenic PMS2 P54278 L98R 98 L R 0.986 Pathogenic PMS2 P54278 L98S 98 L S 0.706 Pathogenic PMS2 P54278 L98T 98 L T 0.626 Pathogenic PMS2 P54278 L98V 98 L V 0.284 Neutral PMS2 P54278 L98W 98 L W 0.878 Pathogenic PMS2 P54278 L98Y 98 L Y 0.89 Pathogenic PMS2 P54278 T99A 99 T A 0.082 Neutral PMS2 P54278 T99C 99 T C 0.46 Neutral PMS2 P54278 T99D 99 T D 0.218 Neutral PMS2 P54278 T99E 99 T E 0.16 Neutral PMS2 P54278 T99F 99 T F 0.462 Neutral PMS2 P54278 T99G 99 T G 0.108 Neutral PMS2 P54278 T99H 99 T H 0.55 Pathogenic PMS2 P54278 T99I 99 T I 0.136 Neutral PMS2 P54278 T99K 99 T K 0.428 Neutral PMS2 P54278 T99L 99 T L 0.09 Neutral PMS2 P54278 T99M 99 T M 0.188 Neutral PMS2 P54278 T99N 99 T N 0.03 Neutral PMS2 P54278 T99P 99 T P 0.384 Neutral PMS2 P54278 T99Q 99 T Q 0.036 Neutral PMS2 P54278 T99R 99 T R 0.674 Pathogenic PMS2 P54278 T99S 99 T S 0.026 Neutral PMS2 P54278 T99V 99 T V 0.1 Neutral PMS2 P54278 T99W 99 T W 0.924 Pathogenic PMS2 P54278 T99Y 99 T Y 0.754 Pathogenic