Mutations in the positions of codons
| Kinase | 1st codon position | 2nd codon position | 3rd codon position | |||
| Affected residues | Independent occurents | Affected residues | Independent occurents | Affected residues | Independent occurents | |
| ACVRL1 | 2 (28.57%) | 3 (37.50%) | 4 (57.14%) | 4 (50.00%) | 1 (14.29%) | 1 (12.50%) |
| AMHR2 | 2 (33.33%) | 2 (28.57%) | 3 (50.00%) | 4 (57.14%) | 1 (16.67%) | 1 (14.29%) |
| BMPR1A | 3 (50.00%) | 3 (50.00%) | 3 (50.00%) | 3 (50.00%) | 0 (0.00%) | 0 (0.00%) |
| BMPR2 | 6 (66.67%) | 11 (78.57%) | 3 (33.33%) | 3 (21.43%) | 0 (0.00%) | 0 (0.00%) |
| BTK | 43 (38.05%) | 84 (40.19%) | 55 (48.67%) | 105 (50.24%) | 15 (13.27%) | 20 (9.57%) |
| CDK4 | 1 (33.33%) | 13 (86.67%) | 2 (66.67%) | 2 (13.33%) | 0 (0.00%) | 0 (0.00%) |
| CHEK2 | 4 (57.14%) | 4 (57.14%) | 3 (42.86%) | 3 (42.86%) | 0 (0.00%) | 0 (0.00%) |
| FGFR1 | 3 (75.00%) | 3 (75.00%) | 1 (25.00%) | 1 (25.00%) | 0 (0.00%) | 0 (0.00%) |
| FGFR2 | 2 (33.33%) | 3 (37.50%) | 3 (50.00%) | 4 (50.00%) | 1 (16.67%) | 1 (12.50%) |
| FGFR3 | 3 (27.27%) | 20 (37.74%) | 4 (36.36%) | 8 (15.09%) | 4 (36.36%) | 25 (47.17%) |
| FLT3 | 3 (30.00%) | 103 (74.64%) | 5 (50.00%) | 21 (15.22%) | 2 (20.00%) | 14 (10.14%) |
| FLT4 | 2 (33.33%) | 2 (28.57%) | 4 (66.67%) | 5 (71.43%) | 0 (0.00%) | 0 (0.00%) |
| GUCY2D | 6 (54.55%) | 14 (56.00%) | 4 (36.36%) | 9 (36.00%) | 1 (9.09%) | 2 (8.00%) |
| INSR | 7 (35.00%) | 7 (25.93%) | 11 (55.00%) | 18 (66.67%) | 2 (10.00%) | 2 (7.41%) |
| IRAK4 | 1 (100.00%) | 4 (100.00%) | 0 (0.00%) | 0 (0.00%) | 0 (0.00%) | 0 (0.00%) |
| JAK3 | 3 (75.00%) | 3 (75.00%) | 0 (0.00%) | 0 (0.00%) | 1 (25.00%) | 1 (25.00%) |
| JAK3dom2 | 0 (0.00%) | 0 (0.00%) | 1 (50.00%) | 1 (50.00%) | 1 (50.00%) | 1 (50.00%) |
| KIT | 13 (56.52%) | 25 (34.72%) | 8 (34.78%) | 44 (61.11%) | 2 (8.70%) | 3 (4.17%) |
| LTK | 1 (100.00%) | 11 (100.00%) | 0 (0.00%) | 0 (0.00%) | 0 (0.00%) | 0 (0.00%) |
| MERTK | 1 (100.00%) | 1 (100.00%) | 0 (0.00%) | 0 (0.00%) | 0 (0.00%) | 0 (0.00%) |
| MET | 10 (58.82%) | 28 (77.78%) | 6 (35.29%) | 7 (19.44%) | 1 (5.88%) | 1 (2.78%) |
| NTRK1 | 9 (75.00%) | 14 (82.35%) | 3 (25.00%) | 3 (17.65%) | 0 (0.00%) | 0 (0.00%) |
| PAK3 | 1 (50.00%) | 1 (50.00%) | 1 (50.00%) | 1 (50.00%) | 0 (0.00%) | 0 (0.00%) |
| PHKG2 | 4 (57.14%) | 5 (55.56%) | 3 (42.86%) | 4 (44.44%) | 0 (0.00%) | 0 (0.00%) |
| RET | 18 (43.90%) | 45 (36.59%) | 15 (36.59%) | 61 (49.59%) | 8 (19.51%) | 17 (13.82%) |
| RHOK | 0 (0.00%) | 0 (0.00%) | 4 (100.00%) | 4 (100.00%) | 0 (0.00%) | 0 (0.00%) |
| ROR2 | 1 (50.00%) | 7 (87.50%) | 0 (0.00%) | 0 (0.00%) | 1 (50.00%) | 1 (12.50%) |
| RPS6KA3 | 15 (60.00%) | 17 (58.62%) | 8 (32.00%) | 10 (34.48%) | 2 (8.00%) | 2 (6.90%) |
| RPS6KA3dom2 | 5 (45.45%) | 5 (45.45%) | 4 (36.36%) | 4 (36.36%) | 2 (18.18%) | 2 (18.18%) |
| STK11 | 18 (54.55%) | 19 (54.29%) | 11 (33.33%) | 12 (34.29%) | 4 (12.12%) | 4 (11.43%) |
| TEK | 1 (50.00%) | 3 (75.00%) | 1 (50.00%) | 1 (25.00%) | 0 (0.00%) | 0 (0.00%) |
| TGFBR2 | 3 (30.00%) | 3 (30.00%) | 6 (60.00%) | 6 (60.00%) | 1 (10.00%) | 1 (10.00%) |
| ZAP70 | 2 (40.00%) | 2 (33.33%) | 1 (20.00%) | 2 (33.33%) | 2 (40.00%) | 2 (33.33%) |
| All kinases | 193 (45.73%) | 465 (50.76%) | 177 (41.94%) | 350 (38.21%) | 52 (12.32%) | 101 (11.03%) |
| Serine/threonine kinases | 64 (49.23%) | 86 (54.78%) | 55 (42.31%) | 60 (38.22%) | 11 (8.46%) | 11 (7.01%) |
| Tyrosine kinases | 129 (44.18%) | 379 (49.93%) | 122 (41.78%) | 290 (38.21%) | 41 (14.04%) | 90 (11.86%) |
