Amino acid substitution frequency

Amino acid substitution frequencies are shown in % calculated from the data of KinMutBase. Frequencies are normalised with amino acid frequencies of the data set and to 100%.

Tyrosine kinases

Structure of insuline receptor kinase domain

%	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
A	0	0	0.14	0.16	0	0	0	0	0	0	0	0	0.12	0	0	0.9	0	0	0	0
C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	2.69	0.15	0	0	0.04	0.66
D	0.47	0	0	2.45	0	0.98	0.06	0	0	0	0	0	0	0	0	0	0	0	0	2.27
E	0.47	0	1.92	0	0	1.47	0	0	3.8	0	0	0	0	0	0	0	0	0.17	0	0
F	0	0.22	0	0	0	0	0	0	0	1.35	0	0	0	0	0	0.15	0	0	0	0.19
G	0	0	0.82	0.33	0	0.16	0	0	0	0	0	0	0	0	1.05	0	0	0.17	0	0
H	0	0	4.81	0	0	0	0	0	0	0	0	0.22	0	0	1.34	0	0	0	0	0.19
I	0	0	0	0	0	0	0	0	0	0	0.46	0	0	0	0	0	0.19	0.5	0	0
K	0	0	0	2.62	0	0	0	0	0.14	0	0.18	1.87	0	0	0.3	0	0	0	0	0
L	0	0	0	0	0.19	0	0	0	0	0	0.37	0	0.95	0	0.15	0.15	0	1.67	0.15	0
M	0	0	0	0	0	0	0	0	0.7	0	0	0	0	0	0	0	0.09	1.84	0	0
N	0	0	0.96	0	0	0	0	0.12	0.7	0	0	0	0	0	0	0	0	0	0	0
P	0.31	0	0	0	0	0	0.06	0	0	2.71	0	0	0	0.09	0.9	0.6	0.19	0	0	0
Q	0	0	0	0.16	0	0	0.06	0	0.28	0	0	0	0	0	4.03	0	0	0	0	0
R	0	0.16	0	0	0	1.14	0.26	0	0.56	0.54	0.18	0	0	0	0	0.6	0	0	0.15	0
S	0	0.05	0	0	0.87	0.33	0	0	0	0.27	0	0.07	0.71	0	0.3	0	0	0	0.08	0.09
T	0.31	0	0	0	0	0	0	0.35	0.14	0	4.65	0.07	0.36	0	0	0	0	0	0	0
V	1.26	0	7.42	0	0	0.81	0	0.12	0	0.27	0.27	0	0	0	0	0	0	0	0	0
W	0	0.11	0	0	0	0.16	0	0	0	0	0	0	0	0	3.58	0	0	0	0	0
X	0	0.11	0	0.49	0	0	0	0	0.28	0.54	0	0	0	1.44	3.58	0.15	0	0	0.42	0.76
Y	0	0.43	11.4	0	0	0	0.19	0	0	0	0	0	0	0	0	0.3	0	0	0	0

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Serine/threonine kinases

Theoretical model of cyclin-dependent kinase 4

%	A	C	D	E	F	G	H	I	K	L	M	N	P	Q	R	S	T	V	W	Y
A	0	0	0	0.81	0	0	0	0	0	0	0	0	0	0	0	0.61	0.53	1.57	0	0
C	0	0	0	0	0	0	0	0	0	0	0	0	0	0	9.42	0	0	0	0.3	0.83
D	0.71	0	0	0	0	2.35	0	0	0	0	0	0.69	0	0	0	0	0	0.79	0	0
E	0.71	0	0	0	0	0.78	0	0	0.68	0	0	0	0	0	0	0	0	0.79	0	0
F	0	0	0	0	0	0	0	0.63	0	1.25	0	0	0	0	0	0.61	0	0.79	0	0
G	0	0	2.53	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0.79	0	0
H	0	0	0.63	0	0	0	0	0	0	0	0	0	0	0	2.02	0	0	0	0	0
I	0	0	0	0	0	0	0	0	0	0	0.33	0	0	0	0	0.61	0.53	0	0	0
K	0	0	0	2.43	0	0	0	0.63	0	0	0	0.34	0	0	0.67	0	0.53	0	0	0
L	0	0	0	0	0.48	0	0.33	0	0	0	0	0	1.08	0	0	0	0	0	0	0
M	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	1.06	1.57	0	0
N	0	0	3.16	0	0	0	0	1.26	0.68	0	0	0	0	0	0	0	0	0	0	0
P	0	0	0	0	0	0	0	0	0	2.5	0	0	0	0	1.35	0.61	0.53	0	0	0
Q	0	0	0	0.81	0	0	0.66	0	0	0	0	0	0	0	2.02	0	0	0	0	0
R	0	0.48	0	0	0	1.57	0	0	0.68	3.75	0.65	0	0	0	0	0	0	0	0	0
S	0	0	0	0	1.9	1.57	0	0	0	0	0	0.69	0.54	0	0	0	0	0	0	0
T	0	0	0	0	0	0	0	0	0	0	0.33	0	0.54	0	0	0	0	0	0	0
V	0.71	0	0.63	0	0	0.78	0	0	0	0	0	0	0	0	0	0	0	0	0	0
W	0	0	0	0	0	0	0	0	0	0	0	0	0	0	5.38	0	0	0	0	0
X	0	0.25	0	3.81	0	0	0	0	0.66	1.26	0	0	0	1.98	12.51	0	0	0	0.72	0.88
Y	0	0.5	1.28	0	0	0	0.6	0	0	0	0	0.35	0	0	0	0	0	0	0	0

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Correlation between serine/treonine and tyrosine kinases

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