Gene_Symbol	UniProtKB_Accession	Amino_acid_substitution	Pathogenicity_based_on_InSiGHT_class_or_PON-MMR_training_dataset
MLH1	P40692	G67R	pathogenic
MLH1	P40692	R265C	pathogenic
MLH1	P40692	C77Y	pathogenic
MLH1	P40692	H329P	pathogenic
MLH1	P40692	I25F	pathogenic
MLH1	P40692	T82I	pathogenic
MLH1	P40692	F80V	pathogenic
MLH1	P40692	M35R	pathogenic
MLH1	P40692	E102K	pathogenic
MLH1	P40692	P28L	pathogenic
MLH1	P40692	D304V	pathogenic
MLH1	P40692	L622H	pathogenic
MLH1	P40692	R226Q	pathogenic
MLH1	P40692	L574P	pathogenic
MLH1	P40692	R265S	pathogenic
MLH1	P40692	G67E	pathogenic
MLH1	P40692	L559R	pathogenic
MLH1	P40692	R659P	pathogenic
MLH1	P40692	V185G	pathogenic
MLH1	P40692	C680R	pathogenic
MLH1	P40692	Q48P	pathogenic
MLH1	P40692	L555P	pathogenic
MLH1	P40692	A608D	pathogenic
MLH1	P40692	A681T	pathogenic
MLH1	P40692	A21V	pathogenic
MLH1	P40692	M35N	pathogenic
MLH1	P40692	L155R	pathogenic
MLH1	P40692	R755S	pathogenic
MLH1	P40692	D63E	pathogenic
MLH1	P40692	S247P	pathogenic
MLH1	P40692	N38H	pathogenic
MLH1	P40692	R100P	pathogenic
MLH1	P40692	G67W	pathogenic
MLH1	P40692	R687W	pathogenic
MLH1	P40692	L582P	pathogenic
MLH1	P40692	S295T	pathogenic
MLH1	P40692	N64S	pathogenic
MLH1	P40692	V49E	pathogenic
MLH1	P40692	L550P	pathogenic
MLH1	P40692	A589D	pathogenic
MLH1	P40692	N38S	pathogenic
MLH1	P40692	E663A	pathogenic
MLH1	P40692	T117M	pathogenic
MLH1	P40692	L749P	pathogenic
MLH1	P40692	P648L	pathogenic
MLH1	P40692	I68N	pathogenic
MLH1	P40692	Q346H	pathogenic
MLH1	P40692	G65D	pathogenic
MLH1	P40692	A21E	pathogenic
MLH1	P40692	K84E	pathogenic
MLH1	P40692	R127K	pathogenic
MLH1	P40692	C39F	pathogenic
MLH1	P40692	N38K	pathogenic
MLH1	P40692	E102D	pathogenic
MLH1	P40692	S44F	pathogenic
MLH1	P40692	D132H	neutral
MLH1	P40692	V213M	neutral
MLH1	P40692	K618A	neutral
MLH1	P40692	E268G	neutral
MLH1	P40692	A282G	neutral
MLH1	P40692	R325Q	neutral
MLH1	P40692	V326A	neutral
MLH1	P40692	T347N	neutral
MLH1	P40692	V384D	neutral
MLH1	P40692	S406N	neutral
MLH1	P40692	E578G	neutral
MLH1	P40692	E600G	neutral
MLH1	P40692	L607H	neutral
MLH1	P40692	K618T	neutral
MLH1	P40692	Q689R	neutral
MLH1	P40692	V716M	neutral
MLH1	P40692	H718Y	neutral
MLH1	P40692	K751R	neutral
MLH1	P40692	S44A	neutral
MLH1	P40692	R182G	neutral
MLH1	P40692	I219V	neutral
MLH1	P40692	I219L	neutral
MLH1	P40692	R265H	neutral
MLH1	P40692	S295G	neutral
MLH1	P40692	T413I	neutral
MLH1	P40692	E460A	neutral
MLH1	P40692	P496L	neutral
MLH1	P40692	I655V	neutral
MLH1	P40692	T662P	neutral
MLH1	P40692	E663G	neutral
MLH1	P40692	E663D	neutral
MLH3	Q9UHC1	Q24E	neutral
MLH3	Q9UHC1	E624Q	neutral
MLH3	Q9UHC1	R647C	neutral
MLH3	Q9UHC1	S817G	neutral
MLH3	Q9UHC1	G933C	neutral
MLH3	Q9UHC1	G981S	neutral
MLH3	Q9UHC1	N1007S	neutral
MLH3	Q9UHC1	W1276R	neutral
MLH3	Q9UHC1	A1394T	neutral
MLH3	Q9UHC1	E1451K	neutral
MSH2	P43246	C199R	pathogenic
MSH2	P43246	G674R	pathogenic
MSH2	P43246	P696L	pathogenic
MSH2	P43246	C697R	pathogenic
MSH2	P43246	R524L	pathogenic
MSH2	P43246	G162R	pathogenic
MSH2	P43246	Q264H	pathogenic
MSH2	P43246	P349L	pathogenic
MSH2	P43246	C697F	pathogenic
MSH2	P43246	L330P	pathogenic
MSH2	P43246	G674D	pathogenic
MSH2	P43246	E749K	pathogenic
MSH2	P43246	D603G	pathogenic
MSH2	P43246	G674A	pathogenic
MSH2	P43246	M688R	pathogenic
MSH2	P43246	R359S	pathogenic
MSH2	P43246	G338E	pathogenic
MSH2	P43246	R524P	pathogenic
MSH2	P43246	G164R	pathogenic
MSH2	P43246	G751R	pathogenic
MSH2	P43246	G683R	pathogenic
MSH2	P43246	G692R	pathogenic
MSH2	P43246	L187P	pathogenic
MSH2	P43246	P349R	pathogenic
MSH2	P43246	P622L	pathogenic
MSH2	P43246	L310P	pathogenic
MSH2	P43246	L93F	pathogenic
MSH2	P43246	A636P	pathogenic
MSH2	P43246	G669R	pathogenic
MSH2	P43246	L187R	pathogenic
MSH2	P43246	A834T	neutral
MSH2	P43246	R106K	neutral
MSH2	P43246	R96H	neutral
MSH2	P43246	N127S	neutral
MSH2	P43246	Q419K	neutral
MSH2	P43246	Q629R	neutral
MSH2	P43246	I169V	neutral
MSH2	P43246	I577T	neutral
MSH2	P43246	M813V	neutral
MSH2	P43246	S860L	neutral
MSH2	P43246	T564A	neutral
MSH2	P43246	V102I	neutral
MSH2	P43246	N331D	neutral
MSH2	P43246	E198G	neutral
MSH2	P43246	G322D	neutral
MSH2	P43246	T8M	neutral
MSH2	P43246	F519L	neutral
MSH2	P43246	A848S	neutral
MSH6	P52701	G686D	pathogenic
MSH6	P52701	V398E	pathogenic
MSH6	P52701	F706S	pathogenic
MSH6	P52701	A81T	neutral
MSH6	P52701	R1304K	neutral
MSH6	P52701	R468H	neutral
MSH6	P52701	E1163V	neutral
MSH6	P52701	E220D	neutral
MSH6	P52701	G39E	neutral
MSH6	P52701	G54A	neutral
MSH6	P52701	I1054F	neutral
MSH6	P52701	S1329L	neutral
MSH6	P52701	S144I	neutral
MSH6	P52701	S227I	neutral
MSH6	P52701	S503C	neutral
MSH6	P52701	S65L	neutral
MSH6	P52701	Y556F	neutral
MSH6	P52701	V509A	neutral
MSH6	P52701	V878A	neutral
MSH6	P52701	L396V	neutral
MSH6	P52701	F340S	neutral
MSH6	P52701	L1354Q	neutral
PMS2	P54278	S46I	pathogenic
PMS2	P54278	R20Q	neutral
PMS2	P54278	R563L	neutral
PMS2	P54278	N775S	neutral
PMS2	P54278	D60E	neutral
PMS2	P54278	G857A	neutral
PMS2	P54278	M622I	neutral
PMS2	P54278	P470S	neutral
PMS2	P54278	T485K	neutral
PMS2	P54278	T511A	neutral
PMS2	P54278	L571I	neutral
PMS2	P54278	T597S	neutral