Protein Structure and Bioinformatics Group

The Protein Structure and Bioinformatics (LU PSB) develops methods and performs analyses to understand biological and medical phenomena at genetic, functional, mechanical, and systems levels.

The group has two major research areas.
One is related to the collection, interpretation, and distribution of information related to variations and their effects at multiple levels.
The major development areas are:

  • Identification and development of prediction tools for pathogenic variations
  • Studies of structural bases of diseases
  • Phenotype-genotype correlations in diseases
  • Protein structure-function relationships
  • Development of systematic representations and standards for variations, their effects, and data systems to store them, including Variation Ontology (VariO)

The other research line is highly related and investigates the effects of variations and perturbations at the systems biological and medical levels. These studies are especially focused on primary immunodeficiencies and cancers.
Developmental areas include:

  • Definition and studies of the immunome
  • Systems biology in relation to human diseases
  • Modeling and simulation of biological systems
  • Analysis of perturbations, including variations, on biological systems
  • Large-scale data analysis

Principal investigator

Mauno Vihinen

Mauno Vihinen

Professor, Lund University, Sweden

Mauno Vihinen is well-known for his experience and interest in investigating variations and their effects whether they emerge at molecular levels (DNA, RNA protein), in structural context or in the cellular networks and pathways. He is the Professor of Medical Structural Biology at Lund University.

Vihinen was the first professor in bioinformatics in Nordic countries when appointed 1998 to University of Tampere, Finland. Throughout his career, his aim has been to combine experimental, theoretical and data analysis methods to obtain holistic understanding of biological and medical problems.

Current studies are devoted into analysis of variations and their effects, including prediction method development, and systems biological studies. The group is interested in many medical applications, especially in the fields of immunology and cancer.

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Group members