PSB_logo

Protein Structure and
Bioinformatics Group

Prof. Mauno Vihinen

Lund University

Protein Structure and Bioinformatics Group

The Protein Structure and Bioinformatics (LU PSB) develops methods and performs analyses to understand biological and medical phenomena at genetic, functional, mechanical and systems level.

The group has two major research areas.
One is related to collection, interpretation and distribution of information related to variations and their effects in multiple levels.
The major development areas are

  • identification and development of prediction tools for pathogenic variations
  • studies of structural bases of diseases
  • phenotype-genotype -correlations in diseases
  • protein structure-function relationships
  • development of systematic representations and standards for variations, their effects, and data systems to store them, including Variation Ontology (VariO)

The other research line in highly related and investigates the effects of the variations and perturbations as systems biological and medical level. These studies are done especially in relation to primary immunodeficiencies and cancers.
Developmental areas include

  • definition and studies of immunome
  • systems biology in relation to human diseases
  • modeling and simulation of biological systems
  • analysis of perturbations, including variations, on biological systems
  • large scale data analysis
Latest news
  • 2017-04-25 New publication: Schaafsma G, Vihinen M. 2017. Large differences in proportions of harmful and benign amino acid substitutions between proteins and diseases. Hum Mutat Accepted Articles doi: 10.1002/humu.23236
  • 2017-04-05 New publication: Niroula A, Vihinen M. 2017. Predicting severity of disease-causing variants. Hum Mutat 38: 357-364 doi: 10.1002/humu.23173
  • 2017-02-23 New publication: Niroula A, Vihinen M. 2017. PON-P and PON-P2 predictor performance in CAGI challenges: Lessons learned. Hum Mutat doi: 10.1002/humu.23199
  • 2017-02-16 VariSNP datasets update: The VariSNP benchmark datasets were updated using dbSNP build 149 (GRCh38p7).
  • 2017-02-06 VariO update: The Variation Ontology VariO was updated to version 1.05.

BMC_view

© Lund University image bank
Home

Databases:
IDbases
KinMutBase
SH2base
ImmunoDeficiency Resource (IDR)
Immunome Knowledge Base (IKB)
GOme

Bioinformatics services:
B-Cell Proteome
Bioinformatics benchmarks
MultiDisp
PID classification
PON-BTK
PON-P2
PON-PS
PON-MMR2
PON-mt-tRNA
PON-Diso
PON-Sol
ProCon
PPSC
VariBench
VariSNP

Standards and guidelines:
VariO
MIASM
HVP Guidelines
Guidelines for prediction tools
Curating gene variant databases
HVP Country Nodes
Recommendations for LSDBs

Research:
Group members
Publications

News from PSB:
News

Links:
Lund University
Medical Faculty
Department of Experimental Medical Science

Lund University, Sweden 2017 ©