Human immune system is one of the most complex but widely
investigated machinery both on molecular and organ level, in normal
state and in diseases. Despite being of intense scientific interest,
the evolutionary history of this system is not well known. There has
been several studies related to the development and evolution of immunological
processes, but a full scale genome and sequence based analysis has
been carried out now, including
893
human genes involved in immune related processes. This study has been
carried out a data mining centered analysis based on the existed data
of NCBI's HomoloGene and TIGR's EGO databases. Philogenetic trees has
been generated for all the
893
gene groups together with the available orthologs from eukaryota genomes.
Results of the analysis has been presented in the ImmTree database
(http://structure.bmc.lu.se/idbase/ImmTree)
which contains the trees and other related data for all the
893
genes.
The main object of the ImmTree database are the human immune system
related genes and the corresponding philogenetic trees which describe
the evolutionary past of each ortholog groups. The genes and trees
are presented in several grouping allowing useful searching features
for the users. Beside of the trees, other data like alignments of the
sequences, statistics on nucleotide changes, domain and ontology data
are also available. The database can serve researchers carrying out
further evolutionary studies of the immune system.
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Search
for Gene Groups |
Here you can perform a complex
search for groups of trees with similar characteristics, eg. trees with
species from the same taxon group or genes with similar ontology terms
etc.
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Search
for Single Genes |
Use this page if you want to find a certain
gene by BI or accession number or keyword search in the description field.
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