Human immune system is one of the most complex but widely investigated machinery both on molecular and organ level, in normal state and in diseases. Despite being of intense scientific interest, the evolutionary history of this system is not well known. There has been several studies related to the development and evolution of immunological processes, but a full scale genome and sequence based analysis has been carried out now, including human genes involved in immune related processes. This study has been carried out a data mining centered analysis based on the existed data of NCBI's HomoloGene and TIGR's EGO databases. Philogenetic trees has been generated for all the gene groups together with the available orthologs from eukaryota genomes. Results of the analysis has been presented in the ImmTree database (http://structure.bmc.lu.se/idbase/ImmTree) which contains the trees and other related data for all the genes.

The main object of the ImmTree database are the human immune system related genes and the corresponding philogenetic trees which describe the evolutionary past of each ortholog groups. The genes and trees are presented in several grouping allowing useful searching features for the users. Beside of the trees, other data like alignments of the sequences, statistics on nucleotide changes, domain and ontology data are also available. The database can serve researchers carrying out further evolutionary studies of the immune system.