Introduction to ImmTree
The database of evolutionary relationships of proteins and genes of the human immune system

Human immune system is one of the most complex but widely investigated machinery both on molecular and organ level, in normal state and in diseases. Despite being of intense scientific interest, the evolutionary history of this system is not well known. There has been several studies related to the development and evolution of immunological processes, but a full scale genome and sequence based analysis has been carried out now, including 893 human genes involved in immune related processes. This study has been carried out a data mining centered analysis based on the existed data of NCBI's HomoloGene and TIGR's EGO databases. Philogenetic trees has been generated for all the 893 gene groups together with the available orthologs from eukaryota genomes. Results of the analysis has been presented in the ImmTree database ( which contains the trees and other related data for all the 893 genes.

The main object of the ImmTree database are the human immune system related genes and the corresponding philogenetic trees which describe the evolutionary past of each ortholog groups. The genes and trees are presented in several grouping allowing useful searching features for the users. Beside of the trees, other data like alignments of the sequences, statistics on nucleotide changes, domain and ontology data are also available. The database can serve researchers carrying out further evolutionary studies of the immune system.

The following services are available:
Search for Gene Groups Here you can perform a complex search for groups of trees with similar characteristics, eg. trees with species from the same taxon group or genes with similar ontology terms etc.

Search for Single Genes Use this page if you want to find a certain gene by BI or accession number or keyword search in the description field.

This site is updated by Gerard Schaafsma
Last modified 14.02.2014