Immune system is a complex machinery, which
is based on the highly coordinated expression of a wide array of genes
and proteins. IKB now covers three databases which were independent earlier: Immunome Database, ImmTree and ImmunomeBase, and additional data.
contains information about immunity related proteins, their domain
structure and the related ontology terms. Information can be found
also about the localization of the coding genes and their comparison
with the existing mouse orthologs. Phylogenetic trees re available for orthologs from
Orthologs for genes in metazoan organisms are available and clustered into two classes or levels.
Vertebrate immunoglobulins (IG), T cell receptors (TR) and major histocompatibility complex (MHC) were excluded from Immunome KnowledgeBase as they are specific of the adaptive immune response and because they are well covered in IMGT®, the international ImMunoGeneTics information system®.
Please cite this article if you use IKB in your
Ortutay C, Siermala M, Vihinen M.
Molecular characterization of the immune system: emergence of proteins,
processes, and domains.
In IKB you can perform searches using gene names, GenBank accession numbers, GI numbers or keywords as queries.