A benchmark database for variations


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4. Variation datasets affecting transcription factor binding sites

This dataset of 21 experimentally proven variations was collected by a literature search for known variations affecting TF binding.  These variations were used to set a threshold for a relevant change in Transcription Factor binding affinity. The variation position mapping is available to the genomic (RefSeq), gene (RefSeq Gene) and cDNA (RefSeq mRNA) levels.

Download: TFBS data
Reference: Laurila K and Lähdesmäki H. Systematic analysis of disease-related regulatory variation classes reveals distinct effects on transcription factor binding. In Silico Biol. 2009, 9, 209-224.   PUBMED